PPBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.79871858
2protein neddylation (GO:0045116)7.34101223
3regulation of platelet activation (GO:0010543)6.10542408
4regulation of platelet aggregation (GO:0090330)6.04867695
5protein retention in ER lumen (GO:0006621)5.76453522
6sequestering of extracellular ligand from receptor (GO:0035581)5.74432143
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.65849766
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.54576747
9wound healing, spreading of epidermal cells (GO:0035313)5.48451023
10blood coagulation, intrinsic pathway (GO:0007597)5.18833094
11wound healing, spreading of cells (GO:0044319)5.17977064
12peptidyl-proline hydroxylation (GO:0019511)5.16515259
13type B pancreatic cell proliferation (GO:0044342)5.15865560
14COPI coating of Golgi vesicle (GO:0048205)5.11483586
15Golgi transport vesicle coating (GO:0048200)5.11483586
16adenosine receptor signaling pathway (GO:0001973)5.09209924
17positive regulation of mast cell activation (GO:0033005)5.08513943
18negative regulation of homotypic cell-cell adhesion (GO:0034111)4.97762227
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.96084254
20negative regulation of platelet activation (GO:0010544)4.87510782
21fibril organization (GO:0097435)4.83323065
22angiogenesis involved in wound healing (GO:0060055)4.78699040
23protein targeting to plasma membrane (GO:0072661)4.78038741
24positive regulation of actin filament depolymerization (GO:0030836)4.73232047
25neutrophil activation (GO:0042119)4.63626352
26lipoxygenase pathway (GO:0019372)4.59158489
27positive regulation of osteoblast proliferation (GO:0033690)4.55243583
28regulation of integrin activation (GO:0033623)4.51330448
29regulation of integrin-mediated signaling pathway (GO:2001044)4.50461035
30negative regulation of norepinephrine secretion (GO:0010700)4.47658091
31low-density lipoprotein particle remodeling (GO:0034374)4.45505965
32membrane raft organization (GO:0031579)4.44799147
33actin filament depolymerization (GO:0030042)4.42023805
34negative regulation of heart rate (GO:0010459)4.40621677
35negative regulation of thymocyte apoptotic process (GO:0070244)4.40212692
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.33133342
37positive regulation of endothelial cell differentiation (GO:0045603)4.30321577
38regulation of tight junction assembly (GO:2000810)4.25575372
39granulocyte activation (GO:0036230)4.16107082
40regulation of macrophage cytokine production (GO:0010935)4.16068170
41low-density lipoprotein particle clearance (GO:0034383)4.14588900
42platelet aggregation (GO:0070527)4.11565444
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.08592903
44response to laminar fluid shear stress (GO:0034616)4.06680252
45protein hydroxylation (GO:0018126)4.06643929
46regulation of metalloenzyme activity (GO:0048552)4.05894137
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.04633632
48vascular smooth muscle contraction (GO:0014829)4.01140589
49extracellular fibril organization (GO:0043206)3.96372786
50cranial suture morphogenesis (GO:0060363)3.94795591
51cellular response to arsenic-containing substance (GO:0071243)3.94420800
52positive regulation of macrophage differentiation (GO:0045651)3.93771885
53regulation of lipoprotein metabolic process (GO:0050746)3.88823860
544-hydroxyproline metabolic process (GO:0019471)3.88211978
55cell adhesion mediated by integrin (GO:0033627)3.87390865
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.86992345
57myeloid cell homeostasis (GO:0002262)3.80562348
58purinergic nucleotide receptor signaling pathway (GO:0035590)3.78662044
59regulation of macrophage derived foam cell differentiation (GO:0010743)3.78131669
60apoptotic cell clearance (GO:0043277)3.77410813
61regulation of homotypic cell-cell adhesion (GO:0034110)3.76048073
62platelet formation (GO:0030220)3.73281091
63positive regulation of fatty acid biosynthetic process (GO:0045723)3.73223748
64positive regulation of receptor recycling (GO:0001921)3.73103205
65negative regulation of cytokine production involved in immune response (GO:0002719)3.73016957
66fusion of sperm to egg plasma membrane (GO:0007342)3.70311320
67megakaryocyte development (GO:0035855)3.70270346
68negative regulation of appetite (GO:0032099)3.69110272
69negative regulation of response to food (GO:0032096)3.69110272
70negative regulation of protein localization to cell surface (GO:2000009)3.68006307
71polyamine biosynthetic process (GO:0006596)3.62775948
72positive regulation of systemic arterial blood pressure (GO:0003084)3.61571333
73* platelet activation (GO:0030168)3.58464007
74regulation of Golgi to plasma membrane protein transport (GO:0042996)3.58015267
75positive regulation of cAMP-mediated signaling (GO:0043950)3.57075633
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.56473003
77dermatan sulfate biosynthetic process (GO:0030208)3.55164801
78hemoglobin metabolic process (GO:0020027)3.53537653
79regulation of MHC class II biosynthetic process (GO:0045346)3.52605169
80negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.51533753
81chondrocyte proliferation (GO:0035988)3.50338462
82folic acid transport (GO:0015884)3.49482593
83positive regulation of blood coagulation (GO:0030194)3.49079903
84positive regulation of hemostasis (GO:1900048)3.49079903
85* platelet degranulation (GO:0002576)3.46327071
86negative regulation of neural precursor cell proliferation (GO:2000178)3.45013117
87craniofacial suture morphogenesis (GO:0097094)3.44853916
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.42216168
89positive regulation of Rho protein signal transduction (GO:0035025)3.41649305
90stress fiber assembly (GO:0043149)3.38740691
91beta-amyloid metabolic process (GO:0050435)3.37895439
92positive regulation of blood vessel endothelial cell migration (GO:0043536)3.35430179
93positive regulation of natural killer cell differentiation (GO:0032825)3.35386048
94collagen fibril organization (GO:0030199)3.35163517
95adhesion of symbiont to host cell (GO:0044650)3.34855473
96virion attachment to host cell (GO:0019062)3.34855473
97regulation of mast cell activation (GO:0033003)3.34187243
98cellular response to interferon-alpha (GO:0035457)3.33695899
99positive regulation of mast cell activation involved in immune response (GO:0033008)3.31282980
100positive regulation of mast cell degranulation (GO:0043306)3.31282980
101positive regulation of vesicle fusion (GO:0031340)3.29387786
102purinergic receptor signaling pathway (GO:0035587)3.29271224
103negative regulation of heart contraction (GO:0045822)3.26341991
104negative regulation of fibrinolysis (GO:0051918)3.26100619
105G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.23282601
106Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22343821
107positive regulation of coagulation (GO:0050820)3.21278378
108leukocyte degranulation (GO:0043299)3.21249337
109dermatan sulfate metabolic process (GO:0030205)3.16050607
110positive regulation of macrophage activation (GO:0043032)3.15666053
111regulation of type B pancreatic cell apoptotic process (GO:2000674)3.12876328
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11711054
113high-density lipoprotein particle remodeling (GO:0034375)3.11489120
114regulation of cholesterol efflux (GO:0010874)3.11071649
115negative regulation of T cell apoptotic process (GO:0070233)3.11020002
116phagocytosis, engulfment (GO:0006911)3.10928756
117barbed-end actin filament capping (GO:0051016)3.10697770
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06868158
119negative regulation of T-helper cell differentiation (GO:0045623)3.06868158
120regulation of mast cell degranulation (GO:0043304)3.06197034
121positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05782914
122positive regulation of epithelial to mesenchymal transition (GO:0010718)3.04613794
123autophagic vacuole fusion (GO:0000046)3.04046717
124positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02837286
125protein maturation by protein folding (GO:0022417)3.02803484
126regulation of blood coagulation (GO:0030193)3.02600733
127regulation of hemostasis (GO:1900046)3.02600733
128reverse cholesterol transport (GO:0043691)3.02358594
129aldehyde catabolic process (GO:0046185)3.00072685
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.99937056
131phospholipid homeostasis (GO:0055091)2.99375843
132extracellular matrix assembly (GO:0085029)2.99062490
133termination of G-protein coupled receptor signaling pathway (GO:0038032)2.98234763
134peptide catabolic process (GO:0043171)2.98077346
135L-ascorbic acid metabolic process (GO:0019852)2.96482035
136termination of signal transduction (GO:0023021)2.96114918
137negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.95328433
138regulation of receptor recycling (GO:0001919)2.95253782
139regulation of mast cell activation involved in immune response (GO:0033006)2.94373078
140cyclooxygenase pathway (GO:0019371)2.92385259
141cortical actin cytoskeleton organization (GO:0030866)2.92270690
142endodermal cell differentiation (GO:0035987)2.91596116
143long-chain fatty acid biosynthetic process (GO:0042759)2.91184298
144mitochondrial calcium ion transport (GO:0006851)2.88600241
145COPII vesicle coating (GO:0048208)2.88194161
146homotypic cell-cell adhesion (GO:0034109)2.87131472
147purine nucleotide salvage (GO:0032261)2.85812701
148epoxygenase P450 pathway (GO:0019373)2.85125046
149regulation of regulatory T cell differentiation (GO:0045589)2.85063147
150regulation of endothelial cell differentiation (GO:0045601)2.84922052
151regulation of norepinephrine secretion (GO:0014061)2.84736708
152superoxide anion generation (GO:0042554)2.84101673
153positive regulation of B cell mediated immunity (GO:0002714)2.82025359
154positive regulation of immunoglobulin mediated immune response (GO:0002891)2.82025359
155negative regulation of interleukin-17 production (GO:0032700)2.81763872
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81038450
157adhesion of symbiont to host (GO:0044406)2.80476374
158negative regulation of protein localization to plasma membrane (GO:1903077)2.80272006
159regulation of SMAD protein import into nucleus (GO:0060390)2.79863539
160membrane invagination (GO:0010324)2.79706979
161neutrophil activation involved in immune response (GO:0002283)2.79417514
162myeloid cell activation involved in immune response (GO:0002275)2.78063685
163positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.77260528
164positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.75906095
165regulation of membrane protein ectodomain proteolysis (GO:0051043)2.75745941
166negative regulation of membrane potential (GO:0045837)2.75495635
167regulation of coagulation (GO:0050818)2.75231802
168sequestering of actin monomers (GO:0042989)2.73024367
169cellular response to vitamin (GO:0071295)2.72848031
170pyrimidine nucleoside catabolic process (GO:0046135)2.72779719
171response to arsenic-containing substance (GO:0046685)2.72471520
172regulation of heterotypic cell-cell adhesion (GO:0034114)2.72394869
173regulation of monocyte chemotaxis (GO:0090025)2.71918810
174positive regulation of collagen biosynthetic process (GO:0032967)2.71916359
175positive regulation of SMAD protein import into nucleus (GO:0060391)2.71548004
176wound healing (GO:0042060)2.71462033
177regulation of protein kinase C signaling (GO:0090036)2.70813069
178regulation of plasminogen activation (GO:0010755)2.70549564
179negative regulation of cytokine secretion (GO:0050710)2.66881408
180gland morphogenesis (GO:0022612)2.65493542
181cellular response to nutrient (GO:0031670)2.62783061
182positive regulation of chemokine biosynthetic process (GO:0045080)2.62361721
183positive regulation of chemokine secretion (GO:0090197)2.58166700
184positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.57968526
185cortical cytoskeleton organization (GO:0030865)2.57441857
186response to fluid shear stress (GO:0034405)2.55383663
187extracellular regulation of signal transduction (GO:1900115)2.54849715
188extracellular negative regulation of signal transduction (GO:1900116)2.54849715
189positive regulation of collagen metabolic process (GO:0010714)2.54456631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.48413178
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.25242728
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.69515693
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.71834305
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.42106784
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.21976432
7SCL_19346495_ChIP-Seq_HPC-7_Human4.01205896
8CLOCK_20551151_ChIP-Seq_293T_Human3.18668961
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16346978
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.99921427
11GATA1_19941826_ChIP-Seq_K562_Human2.93023460
12LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.85368371
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76828625
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71809687
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68816158
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.68755569
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60314037
18GATA1_19941827_ChIP-Seq_MEL_Mouse2.58919194
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.55289576
20SPI1_23127762_ChIP-Seq_K562_Human2.54362546
21GATA2_19941826_ChIP-Seq_K562_Human2.52169598
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.48168813
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.47980564
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.40345527
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23772226
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.21307901
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.15666857
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15307357
29EZH2_22144423_ChIP-Seq_EOC_Human2.10921961
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.08869906
31GATA1_22383799_ChIP-Seq_G1ME_Mouse2.04827186
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01035909
33NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01035909
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.00301823
35CJUN_26792858_Chip-Seq_BT549_Human2.00168785
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98034483
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.97985355
38HTT_18923047_ChIP-ChIP_STHdh_Human1.96833579
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96710181
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95310344
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91500462
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.90649399
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89580978
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89580978
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85925631
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.83437006
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79564387
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77000213
49SOX2_20726797_ChIP-Seq_SW620_Human1.76808431
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75955373
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74812706
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73655061
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73304209
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72017032
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71015203
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.68857602
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68698595
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68516524
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.68446454
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66897919
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.66719447
62GBX2_23144817_ChIP-Seq_PC3_Human1.64444958
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61977927
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61047590
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57538542
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56846125
67ATF3_27146783_Chip-Seq_COLON_Human1.54753882
68GATA1_19941827_ChIP-Seq_MEL86_Mouse1.52218734
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51849164
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50107785
71RUNX_20019798_ChIP-Seq_JUKART_Human1.49667429
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.46741677
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46630295
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46586388
75BRD4_25478319_ChIP-Seq_HGPS_Human1.46107582
76TP53_22127205_ChIP-Seq_IMR90_Human1.43739803
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.43266707
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36211897
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34949726
80RACK7_27058665_Chip-Seq_MCF-7_Human1.31703417
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31438677
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.30086536
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.28588055
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27011905
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24617860
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22168330
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22018362
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20670082
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20666805
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20244165
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19240727
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18681675
93* SPI1_23547873_ChIP-Seq_NB4_Human1.18427586
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.17781729
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16363425
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15977292
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15756276
98SALL4_22934838_ChIP-ChIP_CD34+_Human1.15683293
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13918526
100TAF15_26573619_Chip-Seq_HEK293_Human1.12867563
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12402624
102EOMES_21245162_ChIP-Seq_HESCs_Human1.12372842
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11830333
104ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10979577
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09847716
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09554368
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09421851
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09193974
109SPI1_20517297_ChIP-Seq_HL60_Human1.08666884
110TP53_18474530_ChIP-ChIP_U2OS_Human1.08502568
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06595971
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06520055
113ELK1_19687146_ChIP-ChIP_HELA_Human1.05196443
114TFEB_21752829_ChIP-Seq_HELA_Human1.04019955
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.03500311
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03462299
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.03223912
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02395583
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.02081341
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01857078
121BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01611599
122SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01264993
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00034598
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99768244
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99559226
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99173296
127MYB_26560356_Chip-Seq_TH2_Human0.99025979
128GATA3_27048872_Chip-Seq_THYMUS_Human0.98034711
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97899385
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97868235
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.97247877
132PU_27001747_Chip-Seq_BMDM_Mouse0.97018788
133UTX_26944678_Chip-Seq_JUKART_Human0.95618929
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.95199460
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94871963
136GATA3_26560356_Chip-Seq_TH2_Human0.94249900
137STAT1_20625510_ChIP-Seq_HELA_Human0.93714891
138NFI_21473784_ChIP-Seq_ESCs_Mouse0.93467291
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91724769
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91069190
141CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89737418
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89248770
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88691386
144LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87255155
145* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86791598
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85371719
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82946619
148VDR_24787735_ChIP-Seq_THP-1_Human0.82889450
149IRF1_19129219_ChIP-ChIP_H3396_Human0.82833370
150NCOR1_26117541_ChIP-Seq_K562_Human0.82631139
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.82287833
152TP53_16413492_ChIP-PET_HCT116_Human0.82066587
153EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81961755
154IRF8_27001747_Chip-Seq_BMDM_Mouse0.81734782
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.80877275
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80566016
157OCT1_27270436_Chip-Seq_PROSTATE_Human0.80451392
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.80228123
159LXR_22292898_ChIP-Seq_THP-1_Human0.80087476
160TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79874696
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.79723823
162TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79439734
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.79367071
164GATA1_22025678_ChIP-Seq_K562_Human0.78216418
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77531802
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.76614633
167VDR_22108803_ChIP-Seq_LS180_Human0.75994873
168FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75973897
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75719602
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75711607
171VDR_24763502_ChIP-Seq_THP-1_Human0.75623027
172SMRT_27268052_Chip-Seq_Bcells_Human0.75587586
173EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75559574
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75063360
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74812773
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74701630
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74547337
178CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74392763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.11730392
2MP0003705_abnormal_hypodermis_morpholog5.59633269
3MP0003279_aneurysm5.24896125
4MP0005275_abnormal_skin_tensile4.48470870
5MP0009384_cardiac_valve_regurgitation4.28537305
6MP0001958_emphysema4.14747919
7MP0000465_gastrointestinal_hemorrhage3.29754887
8MP0004510_myositis3.14068624
9MP0005503_abnormal_tendon_morphology3.03818267
10MP0002295_abnormal_pulmonary_circulatio2.92652453
11MP0003806_abnormal_nucleotide_metabolis2.92567963
12MP0003566_abnormal_cell_adhesion2.85017020
13MP0010352_gastrointestinal_tract_polyps2.79806550
14MP0001835_abnormal_antigen_presentation2.54502182
15MP0005023_abnormal_wound_healing2.51319611
16MP0010368_abnormal_lymphatic_system2.42416751
17MP0005167_abnormal_blood-brain_barrier2.22894398
18MP0006054_spinal_hemorrhage1.94273579
19MP0005671_abnormal_response_to1.89070775
20MP0000230_abnormal_systemic_arterial1.87846163
21MP0001533_abnormal_skeleton_physiology1.83981536
22MP0003091_abnormal_cell_migration1.83594545
23MP0004272_abnormal_basement_membrane1.76922942
24MP0005595_abnormal_vascular_smooth1.72410021
25MP0003638_abnormal_response/metabolism_1.68646048
26MP0010155_abnormal_intestine_physiology1.67900194
27MP0002736_abnormal_nociception_after1.67137888
28MP0005084_abnormal_gallbladder_morpholo1.64109228
29MP0004130_abnormal_muscle_cell1.62031189
30MP0001879_abnormal_lymphatic_vessel1.57546311
31MP0003186_abnormal_redox_activity1.56598728
32MP0005164_abnormal_response_to1.55323254
33MP0001545_abnormal_hematopoietic_system1.51800531
34MP0005397_hematopoietic_system_phenotyp1.51800531
35MP0000013_abnormal_adipose_tissue1.51777254
36MP0000343_altered_response_to1.51713636
37MP0001243_abnormal_dermal_layer1.51607633
38MP0001542_abnormal_bone_strength1.51244362
39MP0004036_abnormal_muscle_relaxation1.49665459
40MP0005410_abnormal_fertilization1.48675185
41MP0003436_decreased_susceptibility_to1.44105066
42MP0002060_abnormal_skin_morphology1.44089453
43MP0002398_abnormal_bone_marrow1.42556349
44MP0002723_abnormal_immune_serum1.40838130
45MP0005083_abnormal_biliary_tract1.38125997
46MP0000750_abnormal_muscle_regeneration1.37818469
47MP0001800_abnormal_humoral_immune1.35094920
48MP0000858_altered_metastatic_potential1.32692498
49MP0001663_abnormal_digestive_system1.32003887
50MP0008872_abnormal_physiological_respon1.30718728
51MP0008004_abnormal_stomach_pH1.29010293
52MP0005390_skeleton_phenotype1.27310008
53MP0005623_abnormal_meninges_morphology1.27073343
54MP0003303_peritoneal_inflammation1.25786424
55MP0003879_abnormal_hair_cell1.23469591
56MP0000767_abnormal_smooth_muscle1.23002746
57MP0002132_abnormal_respiratory_system1.22773026
58MP0005025_abnormal_response_to1.19718568
59MP0003950_abnormal_plasma_membrane1.19306907
60MP0002420_abnormal_adaptive_immunity1.18466291
61MP0001177_atelectasis1.17968512
62MP0001819_abnormal_immune_cell1.17023270
63MP0001790_abnormal_immune_system1.16022951
64MP0005387_immune_system_phenotype1.16022951
65MP0010329_abnormal_lipoprotein_level1.15142217
66MP0005646_abnormal_pituitary_gland1.14180360
67MP0008874_decreased_physiological_sensi1.08787890
68MP0001299_abnormal_eye_distance/1.08256246
69MP0000689_abnormal_spleen_morphology1.06876566
70MP0002133_abnormal_respiratory_system1.06611331
71MP0005388_respiratory_system_phenotype1.06611331
72MP0002429_abnormal_blood_cell1.06585873
73MP0000249_abnormal_blood_vessel1.05613362
74MP0008775_abnormal_heart_ventricle1.05143987
75MP0005508_abnormal_skeleton_morphology1.04001900
76MP0003866_abnormal_defecation1.01491030
77MP0003724_increased_susceptibility_to1.00093081
78MP0002419_abnormal_innate_immunity0.99429206
79MP0002733_abnormal_thermal_nociception0.99352207
80MP0001348_abnormal_lacrimal_gland0.99168528
81MP0001968_abnormal_touch/_nociception0.97334541
82MP0000716_abnormal_immune_system0.96326648
83MP0009765_abnormal_xenobiotic_induced0.96238184
84MP0002405_respiratory_system_inflammati0.93959787
85MP0009764_decreased_sensitivity_to0.93481802
86MP0004215_abnormal_myocardial_fiber0.92366350
87MP0002877_abnormal_melanocyte_morpholog0.92340382
88MP0010030_abnormal_orbit_morphology0.92285459
89MP0000015_abnormal_ear_pigmentation0.91018109
90MP0004233_abnormal_muscle_weight0.90695752
91MP0005360_urolithiasis0.90638085
92MP0002722_abnormal_immune_system0.90586230
93MP0004084_abnormal_cardiac_muscle0.90111442
94MP0002128_abnormal_blood_circulation0.89143449
95MP0009642_abnormal_blood_homeostasis0.86925990
96MP0009278_abnormal_bone_marrow0.85755650
97MP0002089_abnormal_postnatal_growth/wei0.83743653
98MP0005058_abnormal_lysosome_morphology0.83474989
99MP0003448_altered_tumor_morphology0.82261948
100MP0002148_abnormal_hypersensitivity_rea0.80838998
101MP0009785_altered_susceptibility_to0.80796898
102MP0005000_abnormal_immune_tolerance0.80727235
103MP0005381_digestive/alimentary_phenotyp0.79965143
104MP0001765_abnormal_ion_homeostasis0.77020056
105MP0004484_altered_response_of0.76543375
106MP0003075_altered_response_to0.76151283
107MP0003795_abnormal_bone_structure0.75429397
108MP0000163_abnormal_cartilage_morphology0.73623781
109MP0005165_increased_susceptibility_to0.72905000
110MP0003656_abnormal_erythrocyte_physiolo0.72478738
111MP0003329_amyloid_beta_deposits0.72336409
112MP0002998_abnormal_bone_remodeling0.70518727
113MP0005464_abnormal_platelet_physiology0.70453378
114MP0003300_gastrointestinal_ulcer0.70449569
115MP0005385_cardiovascular_system_phenoty0.69590484
116MP0001544_abnormal_cardiovascular_syste0.69590484
117MP0003045_fibrosis0.69523109
118MP0001853_heart_inflammation0.69422080
119MP0001614_abnormal_blood_vessel0.69376596
120MP0000759_abnormal_skeletal_muscle0.69211843
121MP0001970_abnormal_pain_threshold0.68905953
122MP0005409_darkened_coat_color0.68864554
123MP0005174_abnormal_tail_pigmentation0.65745995
124MP0001664_abnormal_digestion0.65668850
125MP0000604_amyloidosis0.65505490
126MP0004883_abnormal_blood_vessel0.65438641
127MP0005365_abnormal_bile_salt0.65006596
128MP0001756_abnormal_urination0.64816675
129MP0001849_ear_inflammation0.63837556
130MP0008260_abnormal_autophagy0.63630653
131MP0005670_abnormal_white_adipose0.63303512
132MP0003172_abnormal_lysosome_physiology0.63295690
133MP0006138_congestive_heart_failure0.62908921
134MP0002933_joint_inflammation0.62561446
135MP0002118_abnormal_lipid_homeostasis0.62469901
136MP0005620_abnormal_muscle_contractility0.62081261
137MP0009697_abnormal_copulation0.61086948
138MP0001915_intracranial_hemorrhage0.59821989
139MP0002896_abnormal_bone_mineralization0.58748996
140MP0003115_abnormal_respiratory_system0.58650954
141MP0003453_abnormal_keratinocyte_physiol0.58477371
142MP0004947_skin_inflammation0.57504621
143MP0009333_abnormal_splenocyte_physiolog0.57159091
144MP0003828_pulmonary_edema0.56728626
145MP0003385_abnormal_body_wall0.56657840
146MP0000685_abnormal_immune_system0.56499442
147MP0001845_abnormal_inflammatory_respons0.55702563
148MP0001175_abnormal_lung_morphology0.55518567
149MP0002452_abnormal_antigen_presenting0.55249325
150MP0001851_eye_inflammation0.54779475
151MP0000627_abnormal_mammary_gland0.54547542
152MP0002972_abnormal_cardiac_muscle0.52666858
153MP0000733_abnormal_muscle_development0.52429794
154MP0002168_other_aberrant_phenotype0.52339859
155MP0002396_abnormal_hematopoietic_system0.51660120
156MP0010234_abnormal_vibrissa_follicle0.51598678
157MP0002115_abnormal_skeleton_extremities0.51272824
158MP0009763_increased_sensitivity_to0.51148865

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.93701583
2Abnormal platelet volume (HP:0011876)9.88601615
3Aortic aneurysm (HP:0004942)8.94935371
4Epistaxis (HP:0000421)7.73641348
5Cerebral aneurysm (HP:0004944)7.18806143
6Protrusio acetabuli (HP:0003179)7.09236105
7Gingival bleeding (HP:0000225)6.85676931
8Aortic dissection (HP:0002647)6.39216253
9Premature rupture of membranes (HP:0001788)6.09840817
10Hyperlipoproteinemia (HP:0010980)5.99274669
11Impaired platelet aggregation (HP:0003540)5.74222842
12Abnormal platelet function (HP:0011869)5.74222842
13Dilatation of the ascending aorta (HP:0005111)5.60802411
14Peritonitis (HP:0002586)5.39123274
15Vertebral compression fractures (HP:0002953)4.95712395
16Spontaneous hematomas (HP:0007420)4.71315824
17Right ventricular cardiomyopathy (HP:0011663)4.70913505
18Vascular tortuosity (HP:0004948)4.66392440
19Gastrointestinal dysmotility (HP:0002579)4.57297508
20Abnormal pupillary function (HP:0007686)4.56364658
21Arterial tortuosity (HP:0005116)4.51984045
22Soft skin (HP:0000977)4.32786933
23Poikilocytosis (HP:0004447)4.04210991
24Conjunctival telangiectasia (HP:0000524)4.03720952
25Atrophic scars (HP:0001075)3.85178053
26Acanthocytosis (HP:0001927)3.78823882
27Wormian bones (HP:0002645)3.63877949
28Abnormality of the vasculature of the conjunctiva (HP:0008054)3.63831811
29Aneurysm (HP:0002617)3.53862716
30Joint stiffness (HP:0001387)3.50076413
31Bruising susceptibility (HP:0000978)3.45820319
32Distal arthrogryposis (HP:0005684)3.35794934
33Wrist flexion contracture (HP:0001239)3.33845952
34Round ear (HP:0100830)3.31715575
35Blue sclerae (HP:0000592)3.31700448
36Paralysis (HP:0003470)3.29723556
37Dyschromatopsia (HP:0007641)3.28745539
38Bladder diverticulum (HP:0000015)3.17585170
39Overgrowth (HP:0001548)3.13121399
40Coxa vara (HP:0002812)3.09663602
41Abnormality of macrophages (HP:0004311)3.09163934
42Biconcave vertebral bodies (HP:0004586)3.07402825
43Abnormality of the heme biosynthetic pathway (HP:0010472)3.06959425
44Hand muscle atrophy (HP:0009130)3.01436402
45Fragile skin (HP:0001030)2.88827889
46Shallow orbits (HP:0000586)2.86944575
47Hepatosplenomegaly (HP:0001433)2.86801411
48Nemaline bodies (HP:0003798)2.86408907
49Abnormality of lateral ventricle (HP:0030047)2.86285668
50Type 1 muscle fiber predominance (HP:0003803)2.84370265
51Stomatitis (HP:0010280)2.83827501
52Distal lower limb muscle weakness (HP:0009053)2.75695328
53Xanthomatosis (HP:0000991)2.69500377
54Abnormality of dentin (HP:0010299)2.68951938
55Distal upper limb amyotrophy (HP:0007149)2.68870319
56Upper limb amyotrophy (HP:0009129)2.68870319
57Scapular winging (HP:0003691)2.60506041
58Joint swelling (HP:0001386)2.57004201
59Spinal rigidity (HP:0003306)2.51540541
60Joint hemorrhage (HP:0005261)2.49399000
61Eczematoid dermatitis (HP:0000976)2.44231757
62Abnormality of iron homeostasis (HP:0011031)2.43906528
63Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.40525427
64Increased connective tissue (HP:0009025)2.36450727
65Beaking of vertebral bodies (HP:0004568)2.35939442
66Tinnitus (HP:0000360)2.34178663
67Bowel diverticulosis (HP:0005222)2.32815944
68Ulnar deviation of the wrist (HP:0003049)2.32382509
69Calcaneovalgus deformity (HP:0001848)2.31090930
70Abnormal auditory evoked potentials (HP:0006958)2.28627225
71Increased IgM level (HP:0003496)2.27894505
72Bradycardia (HP:0001662)2.26565448
73Hyperextensible skin (HP:0000974)2.23294716
74Facial diplegia (HP:0001349)2.22755395
75Trismus (HP:0000211)2.19416177
76Elbow flexion contracture (HP:0002987)2.19332336
77Nausea (HP:0002018)2.18514550
78Chronic obstructive pulmonary disease (HP:0006510)2.17993669
79Obstructive lung disease (HP:0006536)2.17993669
80Abnormality of transition element cation homeostasis (HP:0011030)2.17471914
81Abnormality of the acetabulum (HP:0003170)2.17082217
82Upper limb muscle weakness (HP:0003484)2.16983806
83Generalized aminoaciduria (HP:0002909)2.16741816
84Myopathic facies (HP:0002058)2.15738568
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13721270
86Increased serum ferritin (HP:0003281)2.12915535
87Papillary thyroid carcinoma (HP:0002895)2.12701522
88Abnormality of the calcaneus (HP:0008364)2.12635924
89Abnormality of the peritoneum (HP:0002585)2.12204136
90Muscle fiber inclusion bodies (HP:0100299)2.11728880
91Mitral stenosis (HP:0001718)2.11163047
92Myocardial infarction (HP:0001658)2.09183690
93Arterial thrombosis (HP:0004420)2.08896272
94Cervical subluxation (HP:0003308)2.06780710
95Male infertility (HP:0003251)2.06718525
96Abnormal delivery (HP:0001787)2.05603368
97Deformed tarsal bones (HP:0008119)2.03031143
98Increased density of long bones (HP:0006392)2.02444429
99Ectopia lentis (HP:0001083)2.02006022
100Elevated erythrocyte sedimentation rate (HP:0003565)2.01169603
101Prolonged bleeding time (HP:0003010)11.5188563
102Menorrhagia (HP:0000132)10.5117617
103Increased mean platelet volume (HP:0011877)10.4854312
104Ileus (HP:0002595)1.98431454
105Spontaneous abortion (HP:0005268)1.98220635
106Recurrent abscess formation (HP:0002722)1.97396413
107Abnormal hemoglobin (HP:0011902)1.97289101
108Short nail (HP:0001799)1.97251231
109Cardiovascular calcification (HP:0011915)1.96354249
110Dysostosis multiplex (HP:0000943)1.95389838
111Recurrent bacterial skin infections (HP:0005406)1.93182897
112Decreased central vision (HP:0007663)1.91832829
113Tachypnea (HP:0002789)1.91635427
114Infantile muscular hypotonia (HP:0008947)1.88775757
115Encephalitis (HP:0002383)1.88667788
116Episodic fever (HP:0001954)1.88441652
117Spondylolisthesis (HP:0003302)1.88394811
118Ventricular fibrillation (HP:0001663)1.87708237
119Broad metatarsal (HP:0001783)1.85403057
120Dysautonomia (HP:0002459)1.84655321
121Genu recurvatum (HP:0002816)1.83057738
122Basal ganglia calcification (HP:0002135)1.82271829
123Heterochromia iridis (HP:0001100)1.80914767
124Abnormality of the prostate (HP:0008775)1.80439190
125Abnormality of the pericardium (HP:0001697)1.79346806
126Coxa valga (HP:0002673)1.79280537
127Polycythemia (HP:0001901)1.79170907
128Absent phalangeal crease (HP:0006109)1.75123873
129Thyroid-stimulating hormone excess (HP:0002925)1.74649755
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73943127
131Autoimmune hemolytic anemia (HP:0001890)1.73342079
132Decreased muscle mass (HP:0003199)1.72808577
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71959866
1343-Methylglutaconic aciduria (HP:0003535)1.71732414
135Vertigo (HP:0002321)1.71206677
136Hypophosphatemic rickets (HP:0004912)1.68030473
137Osteopenia (HP:0000938)1.66388566
138Abnormality of the distal phalanges of the toes (HP:0010182)1.65505858
139Abnormality of the intrinsic pathway (HP:0010989)1.64563111
140Congenital glaucoma (HP:0001087)1.64147771
141Ankle contracture (HP:0006466)1.63395304
142Difficulty climbing stairs (HP:0003551)1.63385182
143Long palpebral fissure (HP:0000637)1.62767614
144Osteolytic defects of the hand bones (HP:0009699)1.62239195
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.62239195
146Chest pain (HP:0100749)1.61809483
147Distal lower limb amyotrophy (HP:0008944)1.61161784
148Tongue fasciculations (HP:0001308)1.61147387
149Abnormality of the common coagulation pathway (HP:0010990)1.59646884
150Bilateral sensorineural hearing impairment (HP:0008619)1.59461400
151Mucosal telangiectasiae (HP:0100579)1.59098765
152Bifid uvula (HP:0000193)1.58687657
153Broad face (HP:0000283)1.58300777
154Thin skin (HP:0000963)1.58241781
155Leiomyosarcoma (HP:0100243)1.57040236
156Uterine leiomyosarcoma (HP:0002891)1.57040236
157Hyperthyroidism (HP:0000836)1.57029637
158Biliary tract neoplasm (HP:0100574)1.56569346
159Mitral valve prolapse (HP:0001634)1.56303872
160Mitral regurgitation (HP:0001653)1.56202930
161Emphysema (HP:0002097)1.55938498
162Muscle fibrillation (HP:0010546)1.54271413
163Camptodactyly of toe (HP:0001836)1.52577656
164Nonimmune hydrops fetalis (HP:0001790)1.52409818
165Knee flexion contracture (HP:0006380)1.52240889
166Transitional cell carcinoma of the bladder (HP:0006740)1.51333040
167Abnormal ciliary motility (HP:0012262)1.51293524
168Back pain (HP:0003418)1.50362557
169Opisthotonus (HP:0002179)1.50177877
170Thrombophlebitis (HP:0004418)1.49992100
171Aortic valve stenosis (HP:0001650)1.49706093
172Arthropathy (HP:0003040)1.49460092
173Polyphagia (HP:0002591)1.49155375
174Purpura (HP:0000979)1.48805988
175Autoamputation (HP:0001218)1.48608741
176Abnormality of binocular vision (HP:0011514)1.47374307
177Diplopia (HP:0000651)1.47374307
178Thrombocytosis (HP:0001894)1.45972706
179Abnormal spermatogenesis (HP:0008669)1.45463352
180Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44431881
181Increased neuronal autofluorescent lipopigment (HP:0002074)1.42752296
182Increased cerebral lipofuscin (HP:0011813)1.41742980
183Visual hallucinations (HP:0002367)1.41717078
184Thyroid carcinoma (HP:0002890)1.38690385
185Amaurosis fugax (HP:0100576)1.38134074
186Leukocytosis (HP:0001974)1.36801404
187Bladder carcinoma (HP:0002862)1.36762698
188Bladder neoplasm (HP:0009725)1.36762698
189Cerebral hemorrhage (HP:0001342)1.35910193
190Cerebral ischemia (HP:0002637)1.34620268
191Infertility (HP:0000789)1.34289677
192Testicular neoplasm (HP:0010788)1.33929732
193Arthralgia (HP:0002829)1.33238806
194Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.32854419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.52561279
2LIMK15.19579079
3MST44.80671579
4PIK3CG4.51559320
5TESK23.61037770
6TEC3.08585282
7BTK3.01715283
8PIK3CA2.95742076
9PIM22.77921682
10MAPKAPK32.71015303
11SYK2.46728239
12TAOK32.43709444
13ERBB32.31504132
14MYLK2.31184909
15LATS22.30485703
16ERN12.28506673
17BMPR22.27483081
18CSF1R2.26792184
19ZAP702.15441746
20PTK2B2.10493254
21GRK52.08799838
22MINK12.01469152
23MAP3K111.98553353
24FGR1.97830266
25GRK61.91494526
26TTN1.91064094
27PAK31.83489873
28NME21.77894474
29TRPM71.77381060
30ARAF1.73102925
31BLK1.71067624
32EPHA21.70552046
33STK31.58117091
34HCK1.55180142
35RPS6KA41.50235876
36MAP3K31.43716291
37PAK21.43433726
38TRIB31.41439900
39DDR21.38643401
40MAP3K131.38154827
41KDR1.38129803
42FES1.36666290
43FER1.36557453
44ACVR1B1.32553602
45LYN1.29127490
46ADRBK21.26248173
47TAOK21.25625854
48MAP2K11.21943681
49TAOK11.20639536
50MATK1.16059901
51KSR21.11406623
52SCYL21.09663582
53CSK1.07257566
54TXK1.05332842
55MOS1.05167385
56LMTK21.04134424
57DAPK31.03949150
58SIK31.01014130
59EIF2AK11.00863400
60PBK1.00792389
61ITK0.99612042
62TNK20.99456895
63LRRK20.99356024
64MAP3K90.98755691
65MAP2K30.98038351
66PTK20.97628723
67STK240.96505426
68TNIK0.95130876
69CAMKK20.93376508
70ERBB20.92817946
71RAF10.89422112
72IRAK10.89035319
73MARK30.86831770
74PNCK0.83818185
75TLK10.81802919
76PAK10.81081281
77DAPK20.80816259
78PDK10.78206074
79CDC42BPA0.75720333
80TRIM280.74328777
81PKN20.74158127
82EPHB20.73373294
83MAP3K80.72897160
84ADRBK10.71968343
85STK100.70094856
86TBK10.68122783
87RET0.66730432
88RPS6KB20.64860194
89PDPK10.64828401
90MAP3K50.63155960
91RIPK40.62240591
92EPHA30.61326861
93STK40.60306728
94MAPK120.59723971
95EPHB10.59715720
96MAPKAPK50.58333330
97MET0.58052006
98LCK0.57624350
99ABL20.55561678
100BMX0.54614881
101PDGFRA0.53225829
102PDGFRB0.52412039
103FLT30.52022370
104PRKACG0.51240262
105FGFR10.51178826
106CDK140.50952996
107PRKD10.50732891
108JAK10.50549312
109JAK30.47927403
110TGFBR20.46855772
111ROCK10.46230349
112JAK20.45905577
113BMPR1B0.44551624
114PDK20.43852703
115BRAF0.42871812
116NEK90.42834334
117PKN10.42747061
118MAP3K10.41987563
119KSR10.40861888
120IRAK30.40727546
121NUAK10.40147933
122NTRK10.39217557
123ZAK0.39090286
124PAK40.39009552
125MAP3K120.38949356
126FYN0.38314739
127PRKG10.38256310
128PLK20.37459847
129IRAK40.37289512
130DAPK10.37167618
131CDK150.37038719
132MAP4K10.36857899
133MAPKAPK20.36313278
134BRSK20.33637070
135CDK180.33207566
136ILK0.32850962
137YES10.32627972
138EGFR0.32527775
139PRKCQ0.32527357
140CDK11A0.31628412
141PRKCD0.31437113
142CDK60.30758735
143PRKCB0.30411956
144PRKG20.30289827
145SRC0.30132967
146EIF2AK30.29409538
147SGK20.28350833
148INSR0.27507825
149PRKCA0.27467227
150PDK40.27064684
151PDK30.27064684
152MAPK130.25316634
153PAK60.25267100
154IKBKB0.24821569
155DYRK1B0.24078450
156ABL10.22506666
157PIM10.21893829
158IRAK20.21617049
159CAMKK10.20885030
160IGF1R0.20591959
161CAMK1G0.20197466

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.24480289
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.13894765
3Shigellosis_Homo sapiens_hsa051313.11869715
4Malaria_Homo sapiens_hsa051442.95518963
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.76384340
6Vibrio cholerae infection_Homo sapiens_hsa051102.63340883
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.51473511
8Dilated cardiomyopathy_Homo sapiens_hsa054142.21401229
9Leishmaniasis_Homo sapiens_hsa051402.19315725
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.11120343
11Phagosome_Homo sapiens_hsa041452.02744490
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89296517
13Bladder cancer_Homo sapiens_hsa052191.83952859
14Collecting duct acid secretion_Homo sapiens_hsa049661.80804127
15Salmonella infection_Homo sapiens_hsa051321.76153069
16Legionellosis_Homo sapiens_hsa051341.75952206
17* Chemokine signaling pathway_Homo sapiens_hsa040621.75741455
18Focal adhesion_Homo sapiens_hsa045101.65356195
19Nitrogen metabolism_Homo sapiens_hsa009101.64672357
20Proteoglycans in cancer_Homo sapiens_hsa052051.63434860
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.60893707
22Pertussis_Homo sapiens_hsa051331.59758230
23Proteasome_Homo sapiens_hsa030501.58539623
24Adherens junction_Homo sapiens_hsa045201.55667440
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55344265
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53086861
27Glutathione metabolism_Homo sapiens_hsa004801.51848608
28B cell receptor signaling pathway_Homo sapiens_hsa046621.48564037
29Amoebiasis_Homo sapiens_hsa051461.45783385
30ECM-receptor interaction_Homo sapiens_hsa045121.45081291
31Rheumatoid arthritis_Homo sapiens_hsa053231.44746003
32Serotonergic synapse_Homo sapiens_hsa047261.43835349
33Protein export_Homo sapiens_hsa030601.41674399
34Viral myocarditis_Homo sapiens_hsa054161.36588276
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.35561075
36TNF signaling pathway_Homo sapiens_hsa046681.33100434
37HIF-1 signaling pathway_Homo sapiens_hsa040661.32282651
38p53 signaling pathway_Homo sapiens_hsa041151.31944221
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31785422
40Systemic lupus erythematosus_Homo sapiens_hsa053221.30781403
41TGF-beta signaling pathway_Homo sapiens_hsa043501.23066410
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20366899
43Complement and coagulation cascades_Homo sapiens_hsa046101.20361654
44Apoptosis_Homo sapiens_hsa042101.16604355
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15991123
46Alcoholism_Homo sapiens_hsa050341.14083859
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12833002
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11192025
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10010257
50Pancreatic cancer_Homo sapiens_hsa052121.08874609
51Tuberculosis_Homo sapiens_hsa051521.08587978
52Glycerolipid metabolism_Homo sapiens_hsa005611.08186894
53Pancreatic secretion_Homo sapiens_hsa049721.07846880
54T cell receptor signaling pathway_Homo sapiens_hsa046601.06769438
55Chronic myeloid leukemia_Homo sapiens_hsa052201.05772126
56Graft-versus-host disease_Homo sapiens_hsa053321.01935817
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.01830750
58Toxoplasmosis_Homo sapiens_hsa051451.01376091
59Chemical carcinogenesis_Homo sapiens_hsa052041.01300601
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00806619
61Lysosome_Homo sapiens_hsa041420.98073711
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96807514
63Long-term depression_Homo sapiens_hsa047300.95573064
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94943134
65Renin-angiotensin system_Homo sapiens_hsa046140.94290495
66MicroRNAs in cancer_Homo sapiens_hsa052060.93905698
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90391013
68Prion diseases_Homo sapiens_hsa050200.88729737
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87133873
70VEGF signaling pathway_Homo sapiens_hsa043700.87090647
71Platelet activation_Homo sapiens_hsa046110.86978674
72Arginine biosynthesis_Homo sapiens_hsa002200.86267145
73Olfactory transduction_Homo sapiens_hsa047400.85131627
74Asthma_Homo sapiens_hsa053100.85130668
75Arginine and proline metabolism_Homo sapiens_hsa003300.82223419
76* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80099884
77Fatty acid elongation_Homo sapiens_hsa000620.80031339
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79340653
79Primary immunodeficiency_Homo sapiens_hsa053400.79263277
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.78564723
81Endocytosis_Homo sapiens_hsa041440.78234552
82Allograft rejection_Homo sapiens_hsa053300.78163529
83Hematopoietic cell lineage_Homo sapiens_hsa046400.78132135
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77201734
85Rap1 signaling pathway_Homo sapiens_hsa040150.77165627
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77118224
87Biosynthesis of amino acids_Homo sapiens_hsa012300.76705053
88Choline metabolism in cancer_Homo sapiens_hsa052310.75795098
89Linoleic acid metabolism_Homo sapiens_hsa005910.74464597
90Small cell lung cancer_Homo sapiens_hsa052220.73541750
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72930647
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72737569
93Renal cell carcinoma_Homo sapiens_hsa052110.71616554
94Autoimmune thyroid disease_Homo sapiens_hsa053200.70992194
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70290494
96Pentose phosphate pathway_Homo sapiens_hsa000300.70243187
97Morphine addiction_Homo sapiens_hsa050320.69639081
98Circadian entrainment_Homo sapiens_hsa047130.68470689
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67866016
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67423538
101Staphylococcus aureus infection_Homo sapiens_hsa051500.67225702
102Melanoma_Homo sapiens_hsa052180.66872662
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64786801
104Osteoclast differentiation_Homo sapiens_hsa043800.64677863
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64562919
106Mineral absorption_Homo sapiens_hsa049780.63902236
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63152711
108Non-small cell lung cancer_Homo sapiens_hsa052230.62050318
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60299775
110Hepatitis B_Homo sapiens_hsa051610.59414574
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58728397
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.57878575
113Endometrial cancer_Homo sapiens_hsa052130.57097696
114Hippo signaling pathway_Homo sapiens_hsa043900.55866562
115Cardiac muscle contraction_Homo sapiens_hsa042600.55296485
116Ras signaling pathway_Homo sapiens_hsa040140.54339922
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.53967496
118Arachidonic acid metabolism_Homo sapiens_hsa005900.51628541
119Carbon metabolism_Homo sapiens_hsa012000.49731052
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.49125319
121Calcium signaling pathway_Homo sapiens_hsa040200.46787928
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46671062
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46623663
124Galactose metabolism_Homo sapiens_hsa000520.46258064
125N-Glycan biosynthesis_Homo sapiens_hsa005100.46103960
126Tight junction_Homo sapiens_hsa045300.45857950
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44357226
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44099329
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.43952384
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.42378141
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42274365
132PPAR signaling pathway_Homo sapiens_hsa033200.41999621
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41060050
134Gastric acid secretion_Homo sapiens_hsa049710.40877234
135Renin secretion_Homo sapiens_hsa049240.40794538
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.39759559
137GABAergic synapse_Homo sapiens_hsa047270.39638687
138Colorectal cancer_Homo sapiens_hsa052100.39506495
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39195213
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38522668
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.38197979
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37862707
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.35521779
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35057302
145Gap junction_Homo sapiens_hsa045400.33934340
146Other glycan degradation_Homo sapiens_hsa005110.33447734
147Starch and sucrose metabolism_Homo sapiens_hsa005000.32767379
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.28393168
149HTLV-I infection_Homo sapiens_hsa051660.26707354
150Phenylalanine metabolism_Homo sapiens_hsa003600.25680437
151Sulfur metabolism_Homo sapiens_hsa009200.23808547
152Viral carcinogenesis_Homo sapiens_hsa052030.23648858

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