PPAN-P2RY11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.10383309
2NIK/NF-kappaB signaling (GO:0038061)4.31803326
3thymic T cell selection (GO:0045061)4.18871153
4positive regulation of gamma-delta T cell activation (GO:0046645)4.15945541
5response to muramyl dipeptide (GO:0032495)4.06144727
6positive thymic T cell selection (GO:0045059)3.92132670
7negative thymic T cell selection (GO:0045060)3.85178570
8mannose metabolic process (GO:0006013)3.81054749
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64439572
10antigen processing and presentation of endogenous antigen (GO:0019883)3.63701339
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61803500
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.52238490
13negative T cell selection (GO:0043383)3.50914743
14positive regulation by symbiont of host defense response (GO:0052509)3.45464488
15modulation by symbiont of host defense response (GO:0052031)3.45464488
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45464488
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45464488
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.45464488
19modulation by symbiont of host immune response (GO:0052553)3.45464488
20tolerance induction (GO:0002507)3.42921992
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41705076
22T cell selection (GO:0045058)3.41555275
23germinal center formation (GO:0002467)3.38343839
24B cell receptor signaling pathway (GO:0050853)3.33087404
25regulation of histone H3-K27 methylation (GO:0061085)3.29829776
26apoptotic process involved in morphogenesis (GO:0060561)3.27316041
27regulation of gamma-delta T cell activation (GO:0046643)3.24440074
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23906687
29regulation of type I interferon-mediated signaling pathway (GO:0060338)3.19936313
30myeloid dendritic cell differentiation (GO:0043011)3.19887267
313-UTR-mediated mRNA stabilization (GO:0070935)3.19420106
32response to laminar fluid shear stress (GO:0034616)3.18355998
33response to peptidoglycan (GO:0032494)3.16409981
34modulation by symbiont of host cellular process (GO:0044068)3.13104525
35B cell homeostasis (GO:0001782)3.12907187
36negative regulation of cell killing (GO:0031342)3.10410878
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10410878
38T cell migration (GO:0072678)3.09681808
39modulation by virus of host process (GO:0019054)3.06593849
40activation of MAPKKK activity (GO:0000185)3.06494009
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06156653
42regulation of B cell receptor signaling pathway (GO:0050855)3.04637395
43immunoglobulin mediated immune response (GO:0016064)3.03260052
44regulation of gamma-delta T cell differentiation (GO:0045586)2.96107630
45histone H3-K36 demethylation (GO:0070544)2.95694693
46activation of Rac GTPase activity (GO:0032863)2.94712827
47positive T cell selection (GO:0043368)2.94191502
48protein localization to endosome (GO:0036010)2.92348963
49detection of bacterium (GO:0016045)2.87609805
50positive regulation of histone deacetylation (GO:0031065)2.87340354
51regulation of NFAT protein import into nucleus (GO:0051532)2.85099049
52regulation of interleukin-2 biosynthetic process (GO:0045076)2.84790417
53myeloid dendritic cell activation (GO:0001773)2.84421557
54cellular response to interleukin-4 (GO:0071353)2.80747044
55spliceosomal tri-snRNP complex assembly (GO:0000244)2.76101859
56pinocytosis (GO:0006907)2.74746661
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74122833
58positive regulation of B cell differentiation (GO:0045579)2.73016453
59negative regulation of viral release from host cell (GO:1902187)2.72326293
60detection of other organism (GO:0098543)2.67813564
61embryonic process involved in female pregnancy (GO:0060136)2.65073265
62regulation of chromatin binding (GO:0035561)2.63565275
63response to interleukin-15 (GO:0070672)2.63145728
64response to type I interferon (GO:0034340)2.58698489
65regulation of interferon-beta biosynthetic process (GO:0045357)2.58577423
66macrophage activation involved in immune response (GO:0002281)2.57975202
67cellular response to type I interferon (GO:0071357)2.57805005
68type I interferon signaling pathway (GO:0060337)2.57805005
69T cell lineage commitment (GO:0002360)2.57392886
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57258150
71negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56946550
72regulation of monocyte differentiation (GO:0045655)2.49695145
73negative regulation of phagocytosis (GO:0050765)2.48794000
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.48181052
75response to interleukin-4 (GO:0070670)2.47564305
76COPI coating of Golgi vesicle (GO:0048205)2.47343992
77Golgi transport vesicle coating (GO:0048200)2.47343992
78lymphocyte homeostasis (GO:0002260)2.47130237
79leukocyte aggregation (GO:0070486)2.46696236
80intracellular estrogen receptor signaling pathway (GO:0030520)2.44969804
81focal adhesion assembly (GO:0048041)2.44071433
82cell-substrate adherens junction assembly (GO:0007045)2.44071433
83megakaryocyte development (GO:0035855)2.44027685
84signal complex assembly (GO:0007172)2.43027574
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42836136
86activation of JUN kinase activity (GO:0007257)2.42641992
87proline biosynthetic process (GO:0006561)2.42597486
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41096645
89regulation of mammary gland epithelial cell proliferation (GO:0033599)2.40056611
90T-helper 1 type immune response (GO:0042088)2.39734301
91T cell costimulation (GO:0031295)2.37796633
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37172540
93regulation of B cell differentiation (GO:0045577)2.37170990
94negative regulation of cell size (GO:0045792)2.36933228
95negative regulation of myeloid cell apoptotic process (GO:0033033)2.35971838
96adherens junction assembly (GO:0034333)2.35279928
97cellular response to virus (GO:0098586)2.35071864
98positive regulation of protein deacetylation (GO:0090312)2.34503637
99B cell mediated immunity (GO:0019724)2.33987863
100regulation of extracellular matrix disassembly (GO:0010715)2.33523305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.94337120
2VDR_21846776_ChIP-Seq_THP-1_Human3.39799620
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.66767115
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.59253395
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58400501
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.54926476
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49383872
8* LXR_22292898_ChIP-Seq_THP-1_Human2.45638088
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44749143
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.38931933
11TCF7_22412390_ChIP-Seq_EML_Mouse2.36347600
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34582801
13KDM2B_26808549_Chip-Seq_DND41_Human2.19786286
14MAF_26560356_Chip-Seq_TH1_Human2.19670213
15VDR_24763502_ChIP-Seq_THP-1_Human2.06714892
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01193809
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.98088112
18E2F7_22180533_ChIP-Seq_HELA_Human1.97899075
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90810816
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88421751
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86998184
22UTX_26944678_Chip-Seq_JUKART_Human1.86236172
23MAF_26560356_Chip-Seq_TH2_Human1.81022771
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80482496
25RACK7_27058665_Chip-Seq_MCF-7_Human1.79948136
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77043024
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.67168640
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64841747
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61426272
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60903274
31ZNF263_19887448_ChIP-Seq_K562_Human1.60828744
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56052043
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53119128
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.51985692
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49578798
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47194727
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46571418
38CIITA_25753668_ChIP-Seq_RAJI_Human1.46307257
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42348919
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41240331
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40307997
42P68_20966046_ChIP-Seq_HELA_Human1.40069720
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40010452
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39275657
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38405519
46MYB_26560356_Chip-Seq_TH1_Human1.37148568
47NCOR1_26117541_ChIP-Seq_K562_Human1.36991165
48KDM2B_26808549_Chip-Seq_K562_Human1.33978217
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32910002
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31544428
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31049754
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.30918195
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30862564
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30276281
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29984654
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.29960176
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28092149
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26506537
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25751107
60SCL_19346495_ChIP-Seq_HPC-7_Human1.25005895
61MYB_26560356_Chip-Seq_TH2_Human1.23163668
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23154765
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23014705
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.22225755
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20989645
66SPI1_23547873_ChIP-Seq_NB4_Human1.20290663
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18531928
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17652848
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16355117
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15741888
71BCOR_27268052_Chip-Seq_Bcells_Human1.15209084
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14957086
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14956105
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12269088
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11996467
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11893020
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11481744
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10760781
79ATF3_27146783_Chip-Seq_COLON_Human1.10582880
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10346838
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09886772
82SMC4_20622854_ChIP-Seq_HELA_Human1.09774484
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09258194
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09162595
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09109626
86CREB1_26743006_Chip-Seq_LNCaP_Human1.09065593
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07576099
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06475507
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.06471200
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04222558
91SPI1_23127762_ChIP-Seq_K562_Human1.02702915
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02627129
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01278278
94BCL6_27268052_Chip-Seq_Bcells_Human1.00061148
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99814065
96IRF8_27001747_Chip-Seq_BMDM_Mouse0.99078112
97TFEB_21752829_ChIP-Seq_HELA_Human0.97270015
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96690597
99IRF8_21731497_ChIP-ChIP_J774_Mouse0.95820348
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95792905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.29058495
2MP0003763_abnormal_thymus_physiology3.01771567
3MP0000685_abnormal_immune_system2.92078375
4MP0003303_peritoneal_inflammation2.66816203
5MP0005058_abnormal_lysosome_morphology2.65626128
6MP0005451_abnormal_body_composition2.59278796
7MP0005671_abnormal_response_to2.50499455
8MP0003705_abnormal_hypodermis_morpholog2.43534246
9MP0003172_abnormal_lysosome_physiology2.42763757
10MP0003300_gastrointestinal_ulcer2.40892823
11MP0001835_abnormal_antigen_presentation2.39913606
12MP0001790_abnormal_immune_system2.39645227
13MP0005387_immune_system_phenotype2.39645227
14MP0005000_abnormal_immune_tolerance2.33665261
15MP0009333_abnormal_splenocyte_physiolog2.32738726
16MP0001800_abnormal_humoral_immune2.31466693
17MP0005076_abnormal_cell_differentiation2.29387125
18MP0002396_abnormal_hematopoietic_system2.12198275
19MP0004947_skin_inflammation2.03914835
20MP0009278_abnormal_bone_marrow2.02127571
21MP0002452_abnormal_antigen_presenting1.93841489
22MP0002398_abnormal_bone_marrow1.92380107
23MP0002723_abnormal_immune_serum1.92080424
24MP0001873_stomach_inflammation1.89514056
25MP0002420_abnormal_adaptive_immunity1.88470843
26MP0008260_abnormal_autophagy1.88465846
27MP0001819_abnormal_immune_cell1.85894387
28MP0005025_abnormal_response_to1.82682380
29MP0009840_abnormal_foam_cell1.78032243
30MP0002419_abnormal_innate_immunity1.77615456
31MP0005310_abnormal_salivary_gland1.73577930
32MP0001348_abnormal_lacrimal_gland1.71003051
33MP0003453_abnormal_keratinocyte_physiol1.70655889
34MP0002166_altered_tumor_susceptibility1.70216264
35MP0000703_abnormal_thymus_morphology1.66782463
36MP0000716_abnormal_immune_system1.66253417
37MP0001849_ear_inflammation1.61154281
38MP0004808_abnormal_hematopoietic_stem1.60942807
39MP0002877_abnormal_melanocyte_morpholog1.57184610
40MP0004510_myositis1.56609593
41MP0010234_abnormal_vibrissa_follicle1.56545388
42MP0004185_abnormal_adipocyte_glucose1.54754530
43MP0003091_abnormal_cell_migration1.53643672
44MP0002405_respiratory_system_inflammati1.53196914
45MP0002722_abnormal_immune_system1.52074975
46MP0000858_altered_metastatic_potential1.50747888
47MP0010155_abnormal_intestine_physiology1.49523840
48MP0002429_abnormal_blood_cell1.49171792
49MP0001853_heart_inflammation1.48531634
50MP0003191_abnormal_cellular_cholesterol1.44589335
51MP0000689_abnormal_spleen_morphology1.43694742
52MP0005464_abnormal_platelet_physiology1.41867682
53MP0002148_abnormal_hypersensitivity_rea1.38079549
54MP0004381_abnormal_hair_follicle1.36950198
55MP0002998_abnormal_bone_remodeling1.24874702
56MP0003566_abnormal_cell_adhesion1.22407223
57MP0009785_altered_susceptibility_to1.18983060
58MP0002138_abnormal_hepatobiliary_system1.17890804
59MP0001845_abnormal_inflammatory_respons1.17552698
60MP0000490_abnormal_crypts_of1.17380277
61MP0002006_tumorigenesis1.17351352
62MP0001545_abnormal_hematopoietic_system1.17011418
63MP0005397_hematopoietic_system_phenotyp1.17011418
64MP0001533_abnormal_skeleton_physiology1.12876704
65MP0003111_abnormal_nucleus_morphology1.02524618
66MP0005666_abnormal_adipose_tissue1.02469728
67MP0008961_abnormal_basal_metabolism1.02037392
68MP0002009_preneoplasia1.01877695
69MP0002254_reproductive_system_inflammat1.00411748
70MP0005621_abnormal_cell_physiology0.97485434
71MP0001730_embryonic_growth_arrest0.97059019
72MP0003183_abnormal_peptide_metabolism0.96208888
73MP0005375_adipose_tissue_phenotype0.95131265
74MP0002933_joint_inflammation0.91947616
75MP0002089_abnormal_postnatal_growth/wei0.91557891
76MP0002796_impaired_skin_barrier0.90095542
77MP0005360_urolithiasis0.89947894
78MP0002019_abnormal_tumor_incidence0.88156816
79MP0008469_abnormal_protein_level0.87774868
80MP0000003_abnormal_adipose_tissue0.87751109
81MP0000350_abnormal_cell_proliferation0.87722736
82MP0005501_abnormal_skin_physiology0.84530210
83MP0001851_eye_inflammation0.84474259
84MP0000604_amyloidosis0.82211678
85MP0000313_abnormal_cell_death0.79531377
86MP0003866_abnormal_defecation0.78101199
87MP0009931_abnormal_skin_appearance0.77818588
88MP0001216_abnormal_epidermal_layer0.75486343
89MP0001727_abnormal_embryo_implantation0.75354095
90MP0003077_abnormal_cell_cycle0.75127543
91MP0000678_abnormal_parathyroid_gland0.73848277
92MP0006082_CNS_inflammation0.72214127
93MP0000733_abnormal_muscle_development0.71847555
94MP0003656_abnormal_erythrocyte_physiolo0.71497701
95MP0003448_altered_tumor_morphology0.70672698
96MP0010352_gastrointestinal_tract_polyps0.67911951
97MP0005384_cellular_phenotype0.67207191
98MP0002970_abnormal_white_adipose0.66398421
99MP0000609_abnormal_liver_physiology0.65972171
100MP0003075_altered_response_to0.65642888

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)3.76764837
2Eczematoid dermatitis (HP:0000976)3.65989868
3Cellulitis (HP:0100658)3.14042587
4Broad face (HP:0000283)3.10940153
5Hyperacusis (HP:0010780)3.06122209
6Recurrent viral infections (HP:0004429)2.94501956
7Agammaglobulinemia (HP:0004432)2.93291988
8Increased IgE level (HP:0003212)2.92783672
9Colitis (HP:0002583)2.91111610
10Abnormality of macrophages (HP:0004311)2.83515616
11Emphysema (HP:0002097)2.68046291
12Meningitis (HP:0001287)2.65855980
13Mediastinal lymphadenopathy (HP:0100721)2.61748856
14Gastrointestinal inflammation (HP:0004386)2.59532733
15Abnormality of the fingertips (HP:0001211)2.50946702
16Obstructive sleep apnea (HP:0002870)2.50737719
17Panhypogammaglobulinemia (HP:0003139)2.46772802
18Recurrent fungal infections (HP:0002841)2.41523425
19Distal lower limb amyotrophy (HP:0008944)2.38285999
20Lymphopenia (HP:0001888)2.36053077
21Thin bony cortex (HP:0002753)2.35623201
22Abnormality of cells of the lymphoid lineage (HP:0012140)2.33511195
23Recurrent bacterial skin infections (HP:0005406)2.29789186
24Recurrent abscess formation (HP:0002722)2.29363768
25Pustule (HP:0200039)2.29359048
26Inflammation of the large intestine (HP:0002037)2.29340500
27Long palpebral fissure (HP:0000637)2.27969755
28Vasculitis (HP:0002633)2.26894855
29Dysostosis multiplex (HP:0000943)2.26300549
30Papilloma (HP:0012740)2.22768453
31Verrucae (HP:0200043)2.22768453
32Restrictive lung disease (HP:0002091)2.21586153
33Hemorrhage of the eye (HP:0011885)2.21319707
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.20337428
35Abnormality of the thoracic spine (HP:0100711)2.18423613
36Fatigue (HP:0012378)2.16497373
37Viral hepatitis (HP:0006562)2.14082982
38Recurrent sinusitis (HP:0011108)2.13185069
39IgA deficiency (HP:0002720)2.10869306
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.09122440
41Segmental peripheral demyelination/remyelination (HP:0003481)2.08833184
42Obstructive lung disease (HP:0006536)2.08766841
43Chronic obstructive pulmonary disease (HP:0006510)2.08766841
44Cerebral aneurysm (HP:0004944)2.07194333
45Increased cerebral lipofuscin (HP:0011813)2.07186805
46Thoracic kyphosis (HP:0002942)2.07079051
47Hypertensive crisis (HP:0100735)2.05180902
48Easy fatigability (HP:0003388)2.04717805
49Disproportionate tall stature (HP:0001519)2.01295697
50Osteomyelitis (HP:0002754)1.96475795
51Recurrent cutaneous fungal infections (HP:0011370)1.93071664
52Chronic mucocutaneous candidiasis (HP:0002728)1.93071664
53Peripheral hypomyelination (HP:0007182)1.91718105
54Achilles tendon contracture (HP:0001771)1.89358363
55Polygenic inheritance (HP:0010982)1.88901084
56Slow saccadic eye movements (HP:0000514)1.88146719
57Basal cell carcinoma (HP:0002671)1.88090283
58Loss of speech (HP:0002371)1.87957878
59Urticaria (HP:0001025)1.87000820
60Increased neuronal autofluorescent lipopigment (HP:0002074)1.86190203
61J-shaped sella turcica (HP:0002680)1.85760952
62Spontaneous hematomas (HP:0007420)1.82958410
63Premature loss of primary teeth (HP:0006323)1.82765837
64Cholecystitis (HP:0001082)1.82497771
65Abnormal gallbladder physiology (HP:0012438)1.82497771
66Deep palmar crease (HP:0006191)1.82251301
67Abnormality of glycolipid metabolism (HP:0010969)1.80473354
68Abnormality of liposaccharide metabolism (HP:0010968)1.80473354
69Abnormality of glycosphingolipid metabolism (HP:0004343)1.80473354
70Hepatitis (HP:0012115)1.80125526
71Urethral obstruction (HP:0000796)1.78781415
72Neuronal loss in central nervous system (HP:0002529)1.77809716
73IgM deficiency (HP:0002850)1.77659797
74Recurrent skin infections (HP:0001581)1.77164019
75Flat acetabular roof (HP:0003180)1.76079034
76Increased connective tissue (HP:0009025)1.74445254
77Abnormality of T cell physiology (HP:0011840)1.73909972
78Gingivitis (HP:0000230)1.73537323
79Seborrheic dermatitis (HP:0001051)1.73442416
80Mucopolysacchariduria (HP:0008155)1.72051956
81Urinary glycosaminoglycan excretion (HP:0003541)1.72051956
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71868372
83Purpura (HP:0000979)1.71477094
84Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71237220
85Abnormality of polysaccharide metabolism (HP:0011012)1.71237220
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71237220
87Squamous cell carcinoma (HP:0002860)1.68818329
88Upper limb amyotrophy (HP:0009129)1.68595426
89Distal upper limb amyotrophy (HP:0007149)1.68595426
90Stridor (HP:0010307)1.68153842
91Premature skin wrinkling (HP:0100678)1.66725705
92Teleangiectasia of the skin (HP:0100585)1.65892259
93Petechiae (HP:0000967)1.65768896
94Abnormality of the Achilles tendon (HP:0005109)1.65532706
95Progressive external ophthalmoplegia (HP:0000590)1.65418329
96Dislocated radial head (HP:0003083)1.64891345
97Ulnar bowing (HP:0003031)1.64256996
98Acrocyanosis (HP:0001063)1.63665065
99Recurrent bronchitis (HP:0002837)1.62738673
100Progressive muscle weakness (HP:0003323)1.62702535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.28379759
2SMG14.01811002
3TRIB33.94059351
4MAP4K13.16907959
5SIK13.16696261
6EEF2K2.78386296
7CDK122.78337709
8ERN12.63974515
9ICK2.53411356
10IRAK32.32627727
11MAP3K102.30303977
12RIPK42.17401848
13MAP3K142.13683153
14FGFR41.92422775
15MAP3K131.87696525
16SIK31.80015924
17SIK21.78581863
18IRAK41.70237362
19NME21.62759077
20PKN21.56896789
21MAP2K31.51262422
22TAOK21.38605274
23TBK11.37831675
24TNK21.29570699
25TYK21.23079019
26MARK21.05981085
27JAK31.05069634
28PASK1.05019128
29TAOK11.02983644
30CDC42BPA1.02540074
31TTN1.01620695
32MAP3K111.00204694
33CDK40.98051460
34BTK0.97984066
35PRKD20.96504062
36CSF1R0.94580035
37BRD40.94544060
38MTOR0.94181486
39MAPK110.93047128
40ZAP700.90856348
41EPHB10.88076509
42HIPK20.87778684
43IKBKB0.86868187
44IRAK20.85546219
45IKBKE0.85416594
46JAK10.83451645
47MAP3K10.81412266
48BLK0.80270908
49MAP3K30.77964192
50CHUK0.77843237
51CSK0.77460223
52FGFR30.74789274
53MAP3K80.69082434
54CDK90.68649017
55PIM20.68597992
56HCK0.68302979
57PTK60.68104868
58PDGFRA0.67503888
59ITK0.67499222
60CAMK1D0.65869140
61SYK0.64678274
62PDPK10.64186466
63RPS6KC10.63817189
64RPS6KL10.63817189
65EPHA20.63583932
66PAK40.63370133
67MAPK120.63216849
68CDK70.63121929
69CAMKK10.62868660
70RPS6KA20.60309033
71RIPK10.59646196
72TESK20.59626660
73ARAF0.58326750
74RPS6KB20.57289943
75GRK60.56395592
76PDK10.56348487
77STK100.55554734
78FES0.53685125
79NEK90.53614573
80MAPK70.52636018
81MAP3K70.52195685
82MARK30.50677611
83MAP2K20.50642595
84LCK0.50548284
85LYN0.47202820
86MST1R0.47149497
87KSR20.46692786
88TYRO30.46619730
89BMX0.46524459
90MATK0.45687998
91PRKD30.44150174
92CDK60.43692187
93FGR0.43199316
94RPS6KA60.42410935
95MELK0.41666077
96IRAK10.37340184
97RPS6KA10.36840534
98MAPKAPK20.36000050
99RET0.34708218
100PRKCH0.34576627

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.62190364
2B cell receptor signaling pathway_Homo sapiens_hsa046622.43289092
3Acute myeloid leukemia_Homo sapiens_hsa052212.22898417
4Primary immunodeficiency_Homo sapiens_hsa053402.22593012
5Allograft rejection_Homo sapiens_hsa053302.00297480
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.94596473
7Leishmaniasis_Homo sapiens_hsa051401.87313665
8Chronic myeloid leukemia_Homo sapiens_hsa052201.83123612
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83018730
10Autoimmune thyroid disease_Homo sapiens_hsa053201.81340109
11Osteoclast differentiation_Homo sapiens_hsa043801.79037911
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.76474796
13Graft-versus-host disease_Homo sapiens_hsa053321.69270134
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63327414
15Viral myocarditis_Homo sapiens_hsa054161.59898555
16Systemic lupus erythematosus_Homo sapiens_hsa053221.59557319
17T cell receptor signaling pathway_Homo sapiens_hsa046601.54849179
18Non-small cell lung cancer_Homo sapiens_hsa052231.54121760
19Influenza A_Homo sapiens_hsa051641.52538094
20Herpes simplex infection_Homo sapiens_hsa051681.52423810
21Viral carcinogenesis_Homo sapiens_hsa052031.45955842
22Hepatitis B_Homo sapiens_hsa051611.45088246
23Toxoplasmosis_Homo sapiens_hsa051451.44777727
24Measles_Homo sapiens_hsa051621.42626148
25Notch signaling pathway_Homo sapiens_hsa043301.41633491
26Pancreatic cancer_Homo sapiens_hsa052121.40098870
27Asthma_Homo sapiens_hsa053101.38678832
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36561943
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35380776
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33508555
31TNF signaling pathway_Homo sapiens_hsa046681.27468777
32Antigen processing and presentation_Homo sapiens_hsa046121.27467127
33Epstein-Barr virus infection_Homo sapiens_hsa051691.26771955
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.26770665
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25821341
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24696387
37Type I diabetes mellitus_Homo sapiens_hsa049401.23345127
38VEGF signaling pathway_Homo sapiens_hsa043701.23297124
39HTLV-I infection_Homo sapiens_hsa051661.23062184
40Apoptosis_Homo sapiens_hsa042101.22137937
41Bladder cancer_Homo sapiens_hsa052191.18017191
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.16275202
43Tuberculosis_Homo sapiens_hsa051521.15915428
44Hepatitis C_Homo sapiens_hsa051601.10513861
45Endometrial cancer_Homo sapiens_hsa052131.09873289
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.08709135
47Pentose phosphate pathway_Homo sapiens_hsa000301.04778583
48mTOR signaling pathway_Homo sapiens_hsa041501.04038308
49Renal cell carcinoma_Homo sapiens_hsa052111.00343890
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99284743
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98821162
52Staphylococcus aureus infection_Homo sapiens_hsa051500.97000378
53Hematopoietic cell lineage_Homo sapiens_hsa046400.93211344
54Colorectal cancer_Homo sapiens_hsa052100.91343621
55Prostate cancer_Homo sapiens_hsa052150.89228395
56Prolactin signaling pathway_Homo sapiens_hsa049170.87528650
57Shigellosis_Homo sapiens_hsa051310.87099056
58Small cell lung cancer_Homo sapiens_hsa052220.86284096
59Lysosome_Homo sapiens_hsa041420.85619258
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.83464592
61Fructose and mannose metabolism_Homo sapiens_hsa000510.83137896
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82223400
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81425846
64Alcoholism_Homo sapiens_hsa050340.80820662
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80587600
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78665485
67Chemokine signaling pathway_Homo sapiens_hsa040620.77872046
68Prion diseases_Homo sapiens_hsa050200.77744936
69Insulin signaling pathway_Homo sapiens_hsa049100.77480649
70Thyroid cancer_Homo sapiens_hsa052160.76522797
71ErbB signaling pathway_Homo sapiens_hsa040120.76263094
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.75510385
73Glioma_Homo sapiens_hsa052140.72756393
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71095666
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.70595679
76Insulin resistance_Homo sapiens_hsa049310.68990803
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68692611
78MicroRNAs in cancer_Homo sapiens_hsa052060.67229230
79Inositol phosphate metabolism_Homo sapiens_hsa005620.66808914
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.66808524
81GnRH signaling pathway_Homo sapiens_hsa049120.66379080
82HIF-1 signaling pathway_Homo sapiens_hsa040660.64411641
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64164799
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.63535801
85Lysine degradation_Homo sapiens_hsa003100.60432068
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60378611
87Choline metabolism in cancer_Homo sapiens_hsa052310.59850108
88mRNA surveillance pathway_Homo sapiens_hsa030150.59537382
89Malaria_Homo sapiens_hsa051440.58611809
90Rheumatoid arthritis_Homo sapiens_hsa053230.57893079
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54980507
92Salmonella infection_Homo sapiens_hsa051320.53367210
93Spliceosome_Homo sapiens_hsa030400.52987085
94Platelet activation_Homo sapiens_hsa046110.51703107
95MAPK signaling pathway_Homo sapiens_hsa040100.51425185
96Endocytosis_Homo sapiens_hsa041440.51317998
97Galactose metabolism_Homo sapiens_hsa000520.50918727
98Biosynthesis of amino acids_Homo sapiens_hsa012300.50646346
99Proteoglycans in cancer_Homo sapiens_hsa052050.50645932
100FoxO signaling pathway_Homo sapiens_hsa040680.50199892

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