PPAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.97878904
2maturation of SSU-rRNA (GO:0030490)4.82897820
3formation of translation preinitiation complex (GO:0001731)4.67300311
4DNA strand elongation involved in DNA replication (GO:0006271)4.65799612
5ribosomal small subunit assembly (GO:0000028)4.63937026
6DNA replication initiation (GO:0006270)4.54333802
7nucleobase biosynthetic process (GO:0046112)4.48790937
8DNA unwinding involved in DNA replication (GO:0006268)4.46675950
9viral transcription (GO:0019083)4.45489599
10DNA strand elongation (GO:0022616)4.43050373
11translational termination (GO:0006415)4.38613816
12telomere maintenance via semi-conservative replication (GO:0032201)4.33720698
13folic acid-containing compound biosynthetic process (GO:0009396)4.26956489
14ribosome biogenesis (GO:0042254)4.21344783
15protein localization to kinetochore (GO:0034501)4.15015702
16DNA replication-dependent nucleosome assembly (GO:0006335)4.14630000
17DNA replication-dependent nucleosome organization (GO:0034723)4.14630000
18purine nucleobase biosynthetic process (GO:0009113)4.13147921
19translational initiation (GO:0006413)4.05978036
20DNA replication checkpoint (GO:0000076)4.05803479
21ribonucleoprotein complex biogenesis (GO:0022613)4.05271370
22ribosomal small subunit biogenesis (GO:0042274)4.02270447
23translational elongation (GO:0006414)4.01169919
24ribosomal large subunit biogenesis (GO:0042273)3.96890560
25IMP biosynthetic process (GO:0006188)3.92602343
26mitotic chromosome condensation (GO:0007076)3.91612355
27ribosome assembly (GO:0042255)3.88820666
28mitotic nuclear envelope disassembly (GO:0007077)3.86859699
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.83866582
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75797821
31telomere maintenance via recombination (GO:0000722)3.74087875
32rRNA processing (GO:0006364)3.73597177
33mitotic metaphase plate congression (GO:0007080)3.73559563
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65258251
35rRNA metabolic process (GO:0016072)3.61523476
36nuclear envelope disassembly (GO:0051081)3.57818580
37membrane disassembly (GO:0030397)3.57818580
38pseudouridine synthesis (GO:0001522)3.57668275
39protein localization to chromosome, centromeric region (GO:0071459)3.54900699
40protein targeting to ER (GO:0045047)3.53985918
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53243589
42cotranslational protein targeting to membrane (GO:0006613)3.53172018
43folic acid metabolic process (GO:0046655)3.52353397
44mitotic recombination (GO:0006312)3.50788071
45telomere maintenance via telomere lengthening (GO:0010833)3.50183653
46spliceosomal snRNP assembly (GO:0000387)3.48740416
47IMP metabolic process (GO:0046040)3.48271451
48proline biosynthetic process (GO:0006561)3.45177162
49cellular protein complex disassembly (GO:0043624)3.41930702
50peptidyl-arginine omega-N-methylation (GO:0035247)3.41875651
51NIK/NF-kappaB signaling (GO:0038061)3.39944054
52transcription from mitochondrial promoter (GO:0006390)3.39134735
53viral life cycle (GO:0019058)3.38482650
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36941951
55negative regulation of mRNA processing (GO:0050686)3.33102540
56protein localization to endoplasmic reticulum (GO:0070972)3.31444566
57nuclear pore organization (GO:0006999)3.29832509
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.28699120
59chromatin remodeling at centromere (GO:0031055)3.25344606
60CENP-A containing nucleosome assembly (GO:0034080)3.25201297
61metaphase plate congression (GO:0051310)3.21075109
62protein complex disassembly (GO:0043241)3.16618574
63negative regulation of erythrocyte differentiation (GO:0045647)3.15544531
64DNA replication-independent nucleosome assembly (GO:0006336)3.14979263
65DNA replication-independent nucleosome organization (GO:0034724)3.14979263
66DNA duplex unwinding (GO:0032508)3.14948287
67nuclear pore complex assembly (GO:0051292)3.14439300
68negative regulation of mRNA metabolic process (GO:1903312)3.13516723
69regulation of spindle organization (GO:0090224)3.13107106
70DNA geometric change (GO:0032392)3.12846332
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.11889775
72rRNA modification (GO:0000154)3.10908627
73regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08217253
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06494947
75CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.05645202
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.05025150
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05025150
78translation (GO:0006412)3.03134981
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.99705830
80macromolecular complex disassembly (GO:0032984)2.99073653
81RNA catabolic process (GO:0006401)2.97683780
82mRNA catabolic process (GO:0006402)2.96505160
83viral mRNA export from host cell nucleus (GO:0046784)2.96427900
84tRNA methylation (GO:0030488)2.94467068
85negative regulation of RNA splicing (GO:0033119)2.94213810
86mitotic sister chromatid segregation (GO:0000070)2.94107279
87proteasome assembly (GO:0043248)2.91841851
88histone arginine methylation (GO:0034969)2.90431767
89cellular component biogenesis (GO:0044085)2.89130963
90rRNA transcription (GO:0009303)2.88972657
91termination of RNA polymerase II transcription (GO:0006369)2.87457440
92transcription-coupled nucleotide-excision repair (GO:0006283)2.85297654
93RNA splicing, via transesterification reactions (GO:0000375)2.84943254
943-UTR-mediated mRNA stabilization (GO:0070935)2.84898645
95mRNA splicing, via spliceosome (GO:0000398)2.84834624
96RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84834624
97chromatin assembly or disassembly (GO:0006333)2.84757003
98maturation of 5.8S rRNA (GO:0000460)2.84284571
99mitochondrial fusion (GO:0008053)2.82121183
100ncRNA processing (GO:0034470)2.81490671
101nuclear envelope organization (GO:0006998)2.81000700
102regulation of translational fidelity (GO:0006450)2.79939621
103regulation of translational termination (GO:0006449)2.79667730
104pteridine-containing compound biosynthetic process (GO:0042559)2.79595604
105negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76377875
106establishment of chromosome localization (GO:0051303)2.76327155
107regulation of histone H3-K9 methylation (GO:0051570)2.76290016
108telomere organization (GO:0032200)2.74811485
109spliceosomal complex assembly (GO:0000245)2.74561034
110telomere maintenance (GO:0000723)2.73912259
111ncRNA metabolic process (GO:0034660)2.73360651
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73062650
113negative regulation of B cell apoptotic process (GO:0002903)2.71930027
114positive regulation of chromosome segregation (GO:0051984)2.71658274
115histone exchange (GO:0043486)2.71622705
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71492833
117base-excision repair (GO:0006284)2.70185919
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70061343
119nucleobase-containing small molecule interconversion (GO:0015949)2.68741973
120mitochondrial RNA metabolic process (GO:0000959)2.65574761
121peptidyl-arginine methylation (GO:0018216)2.65497039
122peptidyl-arginine N-methylation (GO:0035246)2.65497039
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64976358
124pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.60922685
125nuclear envelope reassembly (GO:0031468)2.59382439
126mitotic nuclear envelope reassembly (GO:0007084)2.59382439
127protein maturation by protein folding (GO:0022417)2.56151553
128regulation of mitochondrial translation (GO:0070129)2.52607049
129T cell lineage commitment (GO:0002360)2.51760164
130protein complex localization (GO:0031503)2.51498471
131regulation of RNA export from nucleus (GO:0046831)2.49879387
132sister chromatid segregation (GO:0000819)2.47735812
133modulation by symbiont of host cellular process (GO:0044068)2.47692025
134apoptotic process involved in morphogenesis (GO:0060561)2.46680388
135pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.46084651
136modulation by virus of host process (GO:0019054)2.44970312
137heterochromatin organization (GO:0070828)2.44752997
138chromosome condensation (GO:0030261)2.44702170
139pinocytosis (GO:0006907)2.43240036
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42321738
141cellular protein complex localization (GO:0034629)2.42164603
142pentose-phosphate shunt (GO:0006098)2.41359918
143activation of MAPKKK activity (GO:0000185)2.41008432
144snRNA metabolic process (GO:0016073)2.39626815
145myeloid dendritic cell differentiation (GO:0043011)2.38703821
146RNA stabilization (GO:0043489)2.36161160
147mRNA stabilization (GO:0048255)2.36161160
148pore complex assembly (GO:0046931)2.35711503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56452302
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.32861588
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79635271
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.32580909
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16121702
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12243355
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83501239
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80730888
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70579696
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.65749102
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.62888783
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59062007
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50002197
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.47193180
15XRN2_22483619_ChIP-Seq_HELA_Human2.32928872
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28123892
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25441994
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24199637
19MYC_22102868_ChIP-Seq_BL_Human2.12979508
20VDR_23849224_ChIP-Seq_CD4+_Human2.10590773
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00482359
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94698603
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92376969
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.91654071
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89977810
26FOXP3_21729870_ChIP-Seq_TREG_Human1.86373648
27DCP1A_22483619_ChIP-Seq_HELA_Human1.82551310
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82222967
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81386567
30GABP_19822575_ChIP-Seq_HepG2_Human1.80489825
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.80432831
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80387052
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79260641
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77868128
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76577460
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74455796
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73401673
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73084086
39LXR_22292898_ChIP-Seq_THP-1_Human1.71973683
40AR_21909140_ChIP-Seq_LNCAP_Human1.71349224
41TTF2_22483619_ChIP-Seq_HELA_Human1.70812524
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70157622
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.67327678
44CIITA_25753668_ChIP-Seq_RAJI_Human1.65878673
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65003945
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56058309
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53774222
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51780162
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.50511739
50* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50382192
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49151089
52KDM5A_27292631_Chip-Seq_BREAST_Human1.48664304
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48016712
54* MAF_26560356_Chip-Seq_TH1_Human1.47620634
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47344042
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.46453409
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46175498
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44199299
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43887178
60VDR_21846776_ChIP-Seq_THP-1_Human1.42487110
61MAF_26560356_Chip-Seq_TH2_Human1.41414822
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40744567
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37837990
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36190597
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35825255
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34883811
67VDR_24763502_ChIP-Seq_THP-1_Human1.34431017
68TCF7_22412390_ChIP-Seq_EML_Mouse1.34346817
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32408157
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.32122793
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30913692
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30806493
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30582861
74ELK1_19687146_ChIP-ChIP_HELA_Human1.30341725
75RACK7_27058665_Chip-Seq_MCF-7_Human1.28317791
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27885543
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26558692
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.26351436
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26337937
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26196493
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26085290
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25512326
83KDM2B_26808549_Chip-Seq_DND41_Human1.24905282
84UTX_26944678_Chip-Seq_JUKART_Human1.24856344
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20569283
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19267062
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.19246667
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18781078
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18206870
90P68_20966046_ChIP-Seq_HELA_Human1.17518891
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16550152
92TFEB_21752829_ChIP-Seq_HELA_Human1.16320516
93NCOR1_26117541_ChIP-Seq_K562_Human1.14542004
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13487206
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.12260966
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12245820
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12079668
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11413551
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09864883
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08393881
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.07921821
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07722951
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07095289
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06496175
105* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04898157
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04467793
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.03642103
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02970871
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01976071
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98845947
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97652030
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96644375
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95594657
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.95025537
115* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93825945
116SPI1_23547873_ChIP-Seq_NB4_Human0.93148757
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91545880
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88570574
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84221710
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83662833
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83439023
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83090618
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.82613589
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82354450
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81463412
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81463412
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81463412
128MYC_18940864_ChIP-ChIP_HL60_Human0.81153041
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80843091
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79617018
131ZNF263_19887448_ChIP-Seq_K562_Human0.79483517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39880704
2MP0004957_abnormal_blastocyst_morpholog4.41608231
3MP0003111_abnormal_nucleus_morphology4.36315232
4MP0010094_abnormal_chromosome_stability4.32876857
5MP0003077_abnormal_cell_cycle3.80885114
6MP0008057_abnormal_DNA_replication3.80777038
7MP0005451_abnormal_body_composition3.33890828
8MP0008058_abnormal_DNA_repair3.03878443
9MP0002396_abnormal_hematopoietic_system2.86722858
10MP0010352_gastrointestinal_tract_polyps2.60936853
11MP0008007_abnormal_cellular_replicative2.57500620
12MP0001730_embryonic_growth_arrest2.35306695
13MP0008932_abnormal_embryonic_tissue2.34135150
14MP0000350_abnormal_cell_proliferation2.25180273
15MP0002877_abnormal_melanocyte_morpholog2.18860031
16MP0010307_abnormal_tumor_latency2.11007326
17MP0005058_abnormal_lysosome_morphology2.02083910
18MP0000490_abnormal_crypts_of2.00854611
19MP0003786_premature_aging1.98158782
20MP0003303_peritoneal_inflammation1.94374693
21MP0003123_paternal_imprinting1.91798588
22MP0003806_abnormal_nucleotide_metabolis1.89267811
23MP0005397_hematopoietic_system_phenotyp1.87156031
24MP0001545_abnormal_hematopoietic_system1.87156031
25MP0004185_abnormal_adipocyte_glucose1.87102676
26MP0001672_abnormal_embryogenesis/_devel1.76437007
27MP0005380_embryogenesis_phenotype1.76437007
28MP0004808_abnormal_hematopoietic_stem1.74449929
29MP0005671_abnormal_response_to1.71531885
30MP0009333_abnormal_splenocyte_physiolog1.70597964
31MP0001697_abnormal_embryo_size1.69688864
32MP0008260_abnormal_autophagy1.67213103
33MP0002080_prenatal_lethality1.66351887
34MP0003763_abnormal_thymus_physiology1.66231412
35MP0001835_abnormal_antigen_presentation1.65807830
36MP0005000_abnormal_immune_tolerance1.63592838
37MP0002019_abnormal_tumor_incidence1.62553943
38MP0003984_embryonic_growth_retardation1.60203203
39MP0001790_abnormal_immune_system1.58617729
40MP0005387_immune_system_phenotype1.58617729
41MP0002088_abnormal_embryonic_growth/wei1.56859954
42MP0000313_abnormal_cell_death1.55801701
43MP0008877_abnormal_DNA_methylation1.54235814
44MP0004233_abnormal_muscle_weight1.52503303
45MP0002085_abnormal_embryonic_tissue1.48091060
46MP0002086_abnormal_extraembryonic_tissu1.47083395
47MP0003718_maternal_effect1.46048150
48MP0004947_skin_inflammation1.41238868
49MP0000678_abnormal_parathyroid_gland1.41191580
50MP0003453_abnormal_keratinocyte_physiol1.41178337
51MP0002084_abnormal_developmental_patter1.38621124
52MP0004197_abnormal_fetal_growth/weight/1.37737454
53MP0002398_abnormal_bone_marrow1.37554560
54MP0000703_abnormal_thymus_morphology1.36943351
55MP0002148_abnormal_hypersensitivity_rea1.34774357
56MP0002722_abnormal_immune_system1.31025071
57MP0005025_abnormal_response_to1.29938217
58MP0005501_abnormal_skin_physiology1.29565184
59MP0000689_abnormal_spleen_morphology1.28753862
60MP0003300_gastrointestinal_ulcer1.27644505
61MP0003567_abnormal_fetal_cardiomyocyte1.22655844
62MP0004510_myositis1.22259510
63MP0009278_abnormal_bone_marrow1.21948887
64MP0002796_impaired_skin_barrier1.19908743
65MP0005076_abnormal_cell_differentiation1.14587009
66MP0005310_abnormal_salivary_gland1.13900022
67MP0001293_anophthalmia1.07747085
68MP0002429_abnormal_blood_cell1.06758507
69MP0002132_abnormal_respiratory_system1.06292369
70MP0000358_abnormal_cell_content/1.06256755
71MP0001348_abnormal_lacrimal_gland1.05999643
72MP0002210_abnormal_sex_determination1.05094968
73MP0002419_abnormal_innate_immunity1.03941826
74MP0001145_abnormal_male_reproductive1.00791613
75MP0000858_altered_metastatic_potential1.00060045
76MP0001853_heart_inflammation0.99726362
77MP0005666_abnormal_adipose_tissue0.98587826
78MP0001661_extended_life_span0.98204475
79MP0003705_abnormal_hypodermis_morpholog0.97455636
80MP0000685_abnormal_immune_system0.95608293
81MP0005464_abnormal_platelet_physiology0.94565095
82MP0000716_abnormal_immune_system0.92972965
83MP0009785_altered_susceptibility_to0.92534479
84MP0006054_spinal_hemorrhage0.89621987
85MP0000003_abnormal_adipose_tissue0.87563776
86MP0001845_abnormal_inflammatory_respons0.87412148
87MP0001929_abnormal_gametogenesis0.86882958
88MP0002089_abnormal_postnatal_growth/wei0.86346192
89MP0002653_abnormal_ependyma_morphology0.86237195
90MP0005023_abnormal_wound_healing0.85920334
91MP0001727_abnormal_embryo_implantation0.84614861
92MP0005375_adipose_tissue_phenotype0.84451186
93MP0003890_abnormal_embryonic-extraembry0.84347182
94MP0004133_heterotaxia0.84061009
95MP0000477_abnormal_intestine_morphology0.83986956
96MP0001800_abnormal_humoral_immune0.83397642
97MP0000653_abnormal_sex_gland0.83303313
98MP0009672_abnormal_birth_weight0.83241185
99MP0005384_cellular_phenotype0.82747221
100MP0003172_abnormal_lysosome_physiology0.81798433
101MP0002405_respiratory_system_inflammati0.81715519
102MP0005075_abnormal_melanosome_morpholog0.81485900
103MP0003186_abnormal_redox_activity0.81246801
104MP0004858_abnormal_nervous_system0.80810078
105MP0001915_intracranial_hemorrhage0.80179308
106MP0005621_abnormal_cell_physiology0.79892477
107MP0009931_abnormal_skin_appearance0.78660416
108MP0001216_abnormal_epidermal_layer0.76946693
109MP0003119_abnormal_digestive_system0.76591315
110MP0002160_abnormal_reproductive_system0.75595970
111MP0010030_abnormal_orbit_morphology0.74074778
112MP0003191_abnormal_cellular_cholesterol0.72588755
113MP0003436_decreased_susceptibility_to0.72246677
114MP0009840_abnormal_foam_cell0.72153189
115MP0002420_abnormal_adaptive_immunity0.70612532
116MP0005623_abnormal_meninges_morphology0.70070156
117MP0000465_gastrointestinal_hemorrhage0.69985369
118MP0003221_abnormal_cardiomyocyte_apopto0.69750491
119MP0006036_abnormal_mitochondrial_physio0.69695882
120MP0001873_stomach_inflammation0.69327653
121MP0001119_abnormal_female_reproductive0.69136154
122MP0001819_abnormal_immune_cell0.68938703
123MP0002006_tumorigenesis0.68884095
124MP0002166_altered_tumor_susceptibility0.66637006
125MP0002111_abnormal_tail_morphology0.65830900
126MP0002452_abnormal_antigen_presenting0.65409376
127MP0003656_abnormal_erythrocyte_physiolo0.65373580
128MP0006292_abnormal_olfactory_placode0.65093297
129MP0000750_abnormal_muscle_regeneration0.65068633
130MP0004264_abnormal_extraembryonic_tissu0.65006786
131MP0003121_genomic_imprinting0.64801912
132MP0010155_abnormal_intestine_physiology0.63181010
133MP0005174_abnormal_tail_pigmentation0.62882845
134MP0002723_abnormal_immune_serum0.62410152
135MP0008770_decreased_survivor_rate0.61735630
136MP0001849_ear_inflammation0.61381471
137MP0005266_abnormal_metabolism0.60647614
138MP0006035_abnormal_mitochondrial_morpho0.60350593
139MP0003566_abnormal_cell_adhesion0.60063090

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.16455533
2Abnormal number of erythroid precursors (HP:0012131)4.96355084
3Birth length less than 3rd percentile (HP:0003561)4.89739420
4Reticulocytopenia (HP:0001896)4.51087663
5Oral leukoplakia (HP:0002745)3.83641898
6Breast hypoplasia (HP:0003187)3.80393774
7Ependymoma (HP:0002888)3.46803313
8Aplastic anemia (HP:0001915)3.44814254
9Selective tooth agenesis (HP:0001592)3.41406398
10Macrocytic anemia (HP:0001972)3.38628759
11Colon cancer (HP:0003003)3.34951714
12Ragged-red muscle fibers (HP:0003200)3.33022692
13Pallor (HP:0000980)3.28537285
14Gastrointestinal stroma tumor (HP:0100723)3.27459325
15Microvesicular hepatic steatosis (HP:0001414)3.26378122
16Rough bone trabeculation (HP:0100670)3.21640877
17Broad distal phalanx of finger (HP:0009836)3.14978679
18Carpal bone hypoplasia (HP:0001498)3.12728213
19Medulloblastoma (HP:0002885)3.02543652
20Patellar aplasia (HP:0006443)3.00544973
21Recurrent viral infections (HP:0004429)2.92245466
22Multiple enchondromatosis (HP:0005701)2.91525204
23Chromsome breakage (HP:0040012)2.84333671
24Absent thumb (HP:0009777)2.83860472
25Trismus (HP:0000211)2.83707108
26IgA deficiency (HP:0002720)2.83374627
27Basal cell carcinoma (HP:0002671)2.81235231
28Aplasia/Hypoplasia of the patella (HP:0006498)2.81090248
29Cerebral hypomyelination (HP:0006808)2.80927877
30Microretrognathia (HP:0000308)2.78814009
31Hyperacusis (HP:0010780)2.78583203
32Thrombocytosis (HP:0001894)2.76950668
33Degeneration of anterior horn cells (HP:0002398)2.74128811
34Abnormality of the anterior horn cell (HP:0006802)2.74128811
35Rhabdomyosarcoma (HP:0002859)2.73893256
36Premature ovarian failure (HP:0008209)2.70092192
37Progressive external ophthalmoplegia (HP:0000590)2.68659739
38Myelodysplasia (HP:0002863)2.65454282
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65453436
40Neoplasm of the pancreas (HP:0002894)2.59689184
41Premature graying of hair (HP:0002216)2.58410754
42Agnosia (HP:0010524)2.58301006
43Abnormality of the preputium (HP:0100587)2.55826398
44Hypertensive crisis (HP:0100735)2.54897933
45Progressive muscle weakness (HP:0003323)2.48695373
46Meckel diverticulum (HP:0002245)2.48278752
47Abnormality of chromosome stability (HP:0003220)2.47939913
48Achilles tendon contracture (HP:0001771)2.46476667
49Cellulitis (HP:0100658)2.46375138
50Abnormality of the ileum (HP:0001549)2.43505664
51Tongue fasciculations (HP:0001308)2.43204598
52Squamous cell carcinoma (HP:0002860)2.42159311
53Colitis (HP:0002583)2.41265935
54Cholecystitis (HP:0001082)2.40663260
55Abnormal gallbladder physiology (HP:0012438)2.40663260
56Impulsivity (HP:0100710)2.40428691
5711 pairs of ribs (HP:0000878)2.37272925
58Bone marrow hypocellularity (HP:0005528)2.34437233
59Agammaglobulinemia (HP:0004432)2.32793880
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31540797
61Abnormal number of incisors (HP:0011064)2.31042769
62Poikiloderma (HP:0001029)2.26544079
63Increased serum ferritin (HP:0003281)2.26394979
64Fatigue (HP:0012378)2.26342084
65Abnormality of reticulocytes (HP:0004312)2.25467024
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.21990675
67Mediastinal lymphadenopathy (HP:0100721)2.21535555
68Absent radius (HP:0003974)2.20701825
69Cellular immunodeficiency (HP:0005374)2.18857700
70Muscle fibrillation (HP:0010546)2.18067918
71Hypergonadotropic hypogonadism (HP:0000815)2.17699755
72Lymphoma (HP:0002665)2.16715549
73Amaurosis fugax (HP:0100576)2.16711430
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.16070332
75Lymphopenia (HP:0001888)2.15179675
76Abnormal trabecular bone morphology (HP:0100671)2.14902219
77Impaired proprioception (HP:0010831)2.14795556
78Neoplasm of striated muscle (HP:0009728)2.14673477
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.13527664
80Tracheoesophageal fistula (HP:0002575)2.09752367
81Abnormality of the Achilles tendon (HP:0005109)2.08716333
82IgM deficiency (HP:0002850)2.08623366
83Prominent nose (HP:0000448)2.06804775
84Secondary amenorrhea (HP:0000869)2.05905924
85Deep palmar crease (HP:0006191)2.03662315
86Small intestinal stenosis (HP:0012848)2.02956173
87Duodenal stenosis (HP:0100867)2.02956173
88Overlapping toe (HP:0001845)2.02521119
89Absent forearm bone (HP:0003953)2.01769827
90Aplasia involving forearm bones (HP:0009822)2.01769827
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.01733152
92Long palpebral fissure (HP:0000637)2.01537883
93Missing ribs (HP:0000921)2.00436210
94Atresia of the external auditory canal (HP:0000413)1.99861508
95Astrocytoma (HP:0009592)1.99224084
96Abnormality of the astrocytes (HP:0100707)1.99224084
97Supernumerary spleens (HP:0009799)1.98883057
98Slender long bone (HP:0003100)1.98594484
99Gastrointestinal inflammation (HP:0004386)1.97936143
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94941985
101Pancytopenia (HP:0001876)1.94633437
102Aplasia/Hypoplasia of the thymus (HP:0010515)1.93748334
103Reticulocytosis (HP:0001923)1.92136037
104Megaloblastic anemia (HP:0001889)1.91779587
105Horseshoe kidney (HP:0000085)1.91476101
106Increased cerebral lipofuscin (HP:0011813)1.91383757
107Sloping forehead (HP:0000340)1.90743173
108Abnormality of the thoracic spine (HP:0100711)1.90283805
109Entropion (HP:0000621)1.88201146
110Neoplasm of the oral cavity (HP:0100649)1.87898530
111Glioma (HP:0009733)1.87750378
112Emphysema (HP:0002097)1.87198429
113Eczematoid dermatitis (HP:0000976)1.86136054
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.85615574
115Cafe-au-lait spot (HP:0000957)1.84805442
116Ulnar bowing (HP:0003031)1.84625611
117Meningitis (HP:0001287)1.84307567
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84108740
119Facial hemangioma (HP:0000329)1.83848288
120Petechiae (HP:0000967)1.83620470
121Thoracic kyphosis (HP:0002942)1.83603319
122Obstructive lung disease (HP:0006536)1.82820007
123Chronic obstructive pulmonary disease (HP:0006510)1.82820007
124Glossoptosis (HP:0000162)1.81382382
125Insomnia (HP:0100785)1.81358193
126Abnormality of pyrimidine metabolism (HP:0004353)1.81181136
127Panhypogammaglobulinemia (HP:0003139)1.80993437
128Type I transferrin isoform profile (HP:0003642)1.80942120
129Upper motor neuron abnormality (HP:0002127)1.80605993
130Distal lower limb amyotrophy (HP:0008944)1.80331590
131Cleft eyelid (HP:0000625)1.79949169
132Proximal placement of thumb (HP:0009623)1.77988132
133Acute lymphatic leukemia (HP:0006721)1.77333405
134Abnormality of glycolysis (HP:0004366)1.76474109
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.75902788
136Asplenia (HP:0001746)1.75876302
137Hepatosplenomegaly (HP:0001433)1.75599045
138Abnormality of the duodenum (HP:0002246)1.74929865
139Triphalangeal thumb (HP:0001199)1.74743181
140Sparse lateral eyebrow (HP:0005338)1.74500515
141Personality changes (HP:0000751)1.74481572
142Sparse eyelashes (HP:0000653)1.72995463
143CNS hypomyelination (HP:0003429)1.72191436
144Duplicated collecting system (HP:0000081)1.70851211
145Deviation of the thumb (HP:0009603)1.70641578
146Hypoplasia of the radius (HP:0002984)1.70508279
147Abnormality of macrophages (HP:0004311)1.70110078
148Recurrent fungal infections (HP:0002841)1.69960102
149Premature skin wrinkling (HP:0100678)1.69795588
150Abnormality of T cell physiology (HP:0011840)1.69309679
151Dysphonia (HP:0001618)1.66423736
152Dysmetric saccades (HP:0000641)1.64733937
153Ureteral duplication (HP:0000073)1.64573906
154Increased IgE level (HP:0003212)1.63761438
155Rhabdomyolysis (HP:0003201)1.62818995
156Seborrheic dermatitis (HP:0001051)1.61963898
157Segmental peripheral demyelination/remyelination (HP:0003481)1.61344383
158Vertebral compression fractures (HP:0002953)1.59834783
159Sparse scalp hair (HP:0002209)1.59779975
160Upper limb muscle weakness (HP:0003484)1.58708553
161Urethral obstruction (HP:0000796)1.58267956
162Self-mutilation (HP:0000742)1.58067915
163Abnormality of the fingertips (HP:0001211)1.57865777
164Fasciculations (HP:0002380)1.57111658
165Inflammation of the large intestine (HP:0002037)1.55985845
166Testicular atrophy (HP:0000029)1.55976762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.30486099
2SMG13.97722568
3WEE13.92157702
4CDC73.34350483
5IRAK33.20805734
6PRPF4B3.10957461
7NEK22.58728043
8EIF2AK12.57061341
9NME22.52889237
10ICK2.33928704
11TSSK62.17328160
12TLK12.06865920
13TTK2.02736713
14ACVR1B2.00744336
15EEF2K1.99006745
16SRPK11.96606375
17CDK71.94676300
18RPS6KB21.92996440
19CDK121.85992803
20STK161.85741175
21MAP3K101.84271095
22EIF2AK31.83107604
23DYRK31.80350431
24MAP4K11.76124725
25TESK21.75608594
26PLK11.73922742
27PIM21.71335383
28BRSK21.65943518
29VRK21.65074974
30VRK11.64764042
31PKN21.63507808
32SCYL21.59030109
33RPS6KA41.57402289
34PLK41.56759928
35NEK11.55530030
36CDK41.54765832
37EPHA21.53260377
38ATR1.52183326
39PASK1.49037451
40FLT31.47959019
41MAP3K141.47260259
42STK101.47074718
43MAP3K81.46269735
44AURKB1.42941456
45SIK11.41115054
46MKNK21.40345870
47CHEK21.37256567
48MKNK11.36511098
49MAP3K111.34137669
50PIM11.28347872
51AURKA1.22601656
52IRAK41.21999435
53MAP3K131.20593178
54CHEK11.13006503
55RIPK41.10946613
56MAP2K31.09634921
57TBK11.03892616
58PAK41.00723654
59ARAF0.99922249
60STK40.98761269
61KDR0.94789864
62TGFBR10.94085855
63BRSK10.92964641
64MAPKAPK30.91782601
65LRRK20.91498987
66ZAK0.87656983
67FGFR40.87238052
68SIK20.86583718
69PLK30.85058593
70PBK0.84613174
71ZAP700.83862510
72CDK20.81664169
73ALK0.74945796
74CSNK2A20.73651190
75ATM0.72752597
76TRIB30.71833326
77BRD40.71264592
78PAK10.70104212
79TTN0.69858940
80MAP3K10.68021379
81CDK90.67720033
82GRK60.67266540
83NME10.63969456
84IRAK20.62975798
85BTK0.62844058
86RPS6KA50.62533167
87PRKCI0.62186436
88MTOR0.60340811
89ERN10.59964390
90CDK80.58744913
91CDK60.55727325
92CSNK2A10.55616209
93BCKDK0.54740796
94TAOK10.54129269
95CCNB10.53687108
96AKT20.52984229
97RAF10.52324845
98TAOK20.52072448
99RPS6KC10.51850397
100RPS6KL10.51850397
101CLK10.48990916
102MAP3K30.48158570
103JAK30.47913788
104CDK10.47394891
105MELK0.47191215
106STK30.46450566
107TAF10.45737436
108PAK20.45715986
109IKBKB0.44471864
110DAPK30.43942961
111SIK30.43487646
112BRAF0.43263754
113BMX0.41118957
114TEC0.40864424
115CSF1R0.39869002
116KIT0.38009305
117TYK20.37453742
118CDC42BPA0.37221924
119MAPK110.36357070
120MATK0.36336607
121PDPK10.34663725
122MAP2K20.33720704
123ILK0.33310952
124EIF2AK20.29352550
125CSNK1E0.29101499
126BLK0.28556718
127RPS6KA10.27768605
128CHUK0.26157699
129PRKDC0.24094462
130TESK10.24090522
131RPS6KA60.24014202

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.87610660
2Mismatch repair_Homo sapiens_hsa034304.13338560
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02541844
4Ribosome_Homo sapiens_hsa030103.83147542
5Spliceosome_Homo sapiens_hsa030403.27481267
6RNA polymerase_Homo sapiens_hsa030203.12616071
7RNA transport_Homo sapiens_hsa030133.11405389
8Base excision repair_Homo sapiens_hsa034103.05087217
9One carbon pool by folate_Homo sapiens_hsa006702.77671544
10Homologous recombination_Homo sapiens_hsa034402.73701216
11Proteasome_Homo sapiens_hsa030502.70825401
12Nucleotide excision repair_Homo sapiens_hsa034202.65368588
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56583691
14Cell cycle_Homo sapiens_hsa041102.44815710
15Pyrimidine metabolism_Homo sapiens_hsa002402.41333471
16Fanconi anemia pathway_Homo sapiens_hsa034601.95176971
17RNA degradation_Homo sapiens_hsa030181.77415370
18Non-homologous end-joining_Homo sapiens_hsa034501.69138143
19Basal transcription factors_Homo sapiens_hsa030221.65264585
20p53 signaling pathway_Homo sapiens_hsa041151.63454453
21Systemic lupus erythematosus_Homo sapiens_hsa053221.62852651
22mRNA surveillance pathway_Homo sapiens_hsa030151.57541912
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54300254
24Other glycan degradation_Homo sapiens_hsa005111.36035608
25Allograft rejection_Homo sapiens_hsa053301.34844019
26Folate biosynthesis_Homo sapiens_hsa007901.23955326
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22390275
28Sulfur relay system_Homo sapiens_hsa041221.21896666
29Purine metabolism_Homo sapiens_hsa002301.19131338
30Epstein-Barr virus infection_Homo sapiens_hsa051691.16553525
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15937957
32Autoimmune thyroid disease_Homo sapiens_hsa053201.10665394
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.06570323
34Pentose phosphate pathway_Homo sapiens_hsa000301.06248325
35Biosynthesis of amino acids_Homo sapiens_hsa012301.04178773
36Viral carcinogenesis_Homo sapiens_hsa052031.04162782
37Herpes simplex infection_Homo sapiens_hsa051681.02483491
38Leishmaniasis_Homo sapiens_hsa051400.99420738
39Antigen processing and presentation_Homo sapiens_hsa046120.97748050
40Graft-versus-host disease_Homo sapiens_hsa053320.97289178
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.97188706
42Selenocompound metabolism_Homo sapiens_hsa004500.96213676
43Viral myocarditis_Homo sapiens_hsa054160.96005235
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90917541
45Pancreatic cancer_Homo sapiens_hsa052120.90612157
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.90030862
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89018403
48Vitamin B6 metabolism_Homo sapiens_hsa007500.88697513
49Osteoclast differentiation_Homo sapiens_hsa043800.85377455
50Asthma_Homo sapiens_hsa053100.84153963
51TNF signaling pathway_Homo sapiens_hsa046680.80884428
52Primary immunodeficiency_Homo sapiens_hsa053400.78806135
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76970063
54Prion diseases_Homo sapiens_hsa050200.76373840
55HTLV-I infection_Homo sapiens_hsa051660.74462672
56Thyroid cancer_Homo sapiens_hsa052160.73329331
57Toxoplasmosis_Homo sapiens_hsa051450.72032334
58VEGF signaling pathway_Homo sapiens_hsa043700.69388018
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65883938
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65739337
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64007831
62Oocyte meiosis_Homo sapiens_hsa041140.63292109
63Small cell lung cancer_Homo sapiens_hsa052220.61839507
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61497363
65Type I diabetes mellitus_Homo sapiens_hsa049400.60879248
66Hepatitis C_Homo sapiens_hsa051600.59436874
67Legionellosis_Homo sapiens_hsa051340.56198230
68N-Glycan biosynthesis_Homo sapiens_hsa005100.55428266
69Apoptosis_Homo sapiens_hsa042100.53316047
70MicroRNAs in cancer_Homo sapiens_hsa052060.53013345
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51672897
72Acute myeloid leukemia_Homo sapiens_hsa052210.51609504
73Tuberculosis_Homo sapiens_hsa051520.50610605
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50442495
75Carbon metabolism_Homo sapiens_hsa012000.50161287
76Alcoholism_Homo sapiens_hsa050340.49779135
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49049611
78Lysosome_Homo sapiens_hsa041420.47665523
79Fructose and mannose metabolism_Homo sapiens_hsa000510.47228432
80Bladder cancer_Homo sapiens_hsa052190.45818509
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45524179
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.44678599
83Measles_Homo sapiens_hsa051620.44577743
84Glutathione metabolism_Homo sapiens_hsa004800.44123582
85Chronic myeloid leukemia_Homo sapiens_hsa052200.42929342
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.42427351
87Galactose metabolism_Homo sapiens_hsa000520.41854906
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40882197
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.40858143
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40490825
91Notch signaling pathway_Homo sapiens_hsa043300.39287417
92Hepatitis B_Homo sapiens_hsa051610.38727112
93Protein export_Homo sapiens_hsa030600.37313796
94Colorectal cancer_Homo sapiens_hsa052100.36422102
95Shigellosis_Homo sapiens_hsa051310.34864816
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32914591
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29071305
98mTOR signaling pathway_Homo sapiens_hsa041500.28934566
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28128859
100HIF-1 signaling pathway_Homo sapiens_hsa040660.27944867
101Influenza A_Homo sapiens_hsa051640.26833290
102TGF-beta signaling pathway_Homo sapiens_hsa043500.24858171
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24559419
104Hematopoietic cell lineage_Homo sapiens_hsa046400.24361770
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.22029504
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21811032
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21788466
108Lysine degradation_Homo sapiens_hsa003100.20287447
109Renin-angiotensin system_Homo sapiens_hsa046140.19508178
110B cell receptor signaling pathway_Homo sapiens_hsa046620.18316395
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18101497
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17181661
113Metabolic pathways_Homo sapiens_hsa011000.17054419
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16167328
115Pathways in cancer_Homo sapiens_hsa052000.15313162
116Huntingtons disease_Homo sapiens_hsa050160.15002811
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14584125
118Arginine and proline metabolism_Homo sapiens_hsa003300.14532752
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13934432
120T cell receptor signaling pathway_Homo sapiens_hsa046600.13538324
121Hippo signaling pathway_Homo sapiens_hsa043900.13166316
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13017311
123Non-small cell lung cancer_Homo sapiens_hsa052230.12192796
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.11128845

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