POU6F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.02037321
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93847034
3vocalization behavior (GO:0071625)4.85504865
4positive regulation of synapse assembly (GO:0051965)4.72030160
5dendritic spine morphogenesis (GO:0060997)4.69601830
6pyrimidine nucleobase catabolic process (GO:0006208)4.63695538
7neuron recognition (GO:0008038)4.59603608
8regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.58580636
9protein localization to synapse (GO:0035418)4.49233739
10presynaptic membrane assembly (GO:0097105)4.26277290
11regulation of glutamate receptor signaling pathway (GO:1900449)4.21970312
12axonal fasciculation (GO:0007413)4.18109563
13proline transport (GO:0015824)4.15758694
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.05500696
15transmission of nerve impulse (GO:0019226)4.02658634
16otic vesicle formation (GO:0030916)3.98486569
17negative regulation of synaptic transmission, GABAergic (GO:0032229)3.96909538
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.91793513
19regulation of respiratory system process (GO:0044065)3.87336007
20glutamate receptor signaling pathway (GO:0007215)3.82686296
21nonmotile primary cilium assembly (GO:0035058)3.75972533
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75121378
23regulation of synapse assembly (GO:0051963)3.73046154
24postsynaptic membrane organization (GO:0001941)3.70861552
25presynaptic membrane organization (GO:0097090)3.70663086
26dendrite development (GO:0016358)3.70517471
27opioid receptor signaling pathway (GO:0038003)3.66913954
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.66016462
29protein localization to cilium (GO:0061512)3.64893091
30kidney morphogenesis (GO:0060993)3.62862480
31response to histamine (GO:0034776)3.58791243
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55276463
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54834793
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50768606
35cell migration in hindbrain (GO:0021535)3.49860630
36regulation of respiratory gaseous exchange (GO:0043576)3.47996182
37nucleobase catabolic process (GO:0046113)3.46629406
38synaptic vesicle exocytosis (GO:0016079)3.43922576
39startle response (GO:0001964)3.41857115
40dopamine transport (GO:0015872)3.39930269
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26117106
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21647619
43hindbrain development (GO:0030902)3.19977668
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18496299
45lateral sprouting from an epithelium (GO:0060601)3.17161784
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17104729
47glomerular basement membrane development (GO:0032836)3.14675605
48ATP synthesis coupled proton transport (GO:0015986)3.12796630
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12796630
50cellular ketone body metabolic process (GO:0046950)3.10301744
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10052436
52synaptic transmission, glutamatergic (GO:0035249)3.08774902
53retinal ganglion cell axon guidance (GO:0031290)3.08635352
54response to pheromone (GO:0019236)3.08164891
55spinal cord association neuron differentiation (GO:0021527)3.06865563
56neuron-neuron synaptic transmission (GO:0007270)3.04936931
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04659934
58protein polyglutamylation (GO:0018095)3.04140465
59central nervous system projection neuron axonogenesis (GO:0021952)3.01599934
60respiratory chain complex IV assembly (GO:0008535)3.00253503
61limb bud formation (GO:0060174)2.98398131
62exploration behavior (GO:0035640)2.98082956
63cilium morphogenesis (GO:0060271)2.97691204
64platelet dense granule organization (GO:0060155)2.97349321
65regulation of cilium movement (GO:0003352)2.97144953
66protein complex biogenesis (GO:0070271)2.97044917
67membrane hyperpolarization (GO:0060081)2.96600481
68water-soluble vitamin biosynthetic process (GO:0042364)2.94645442
69behavioral response to nicotine (GO:0035095)2.92739067
70regulation of synaptic transmission, GABAergic (GO:0032228)2.91808544
71radial glial cell differentiation (GO:0060019)2.90460341
72regulation of cAMP-dependent protein kinase activity (GO:2000479)2.89507687
73regulation of postsynaptic membrane potential (GO:0060078)2.89457694
74mechanosensory behavior (GO:0007638)2.88765958
75cerebellum development (GO:0021549)2.88535140
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88303811
77positive regulation of amino acid transport (GO:0051957)2.87453401
78neurotransmitter secretion (GO:0007269)2.87111252
79daunorubicin metabolic process (GO:0044597)2.86741582
80polyketide metabolic process (GO:0030638)2.86741582
81doxorubicin metabolic process (GO:0044598)2.86741582
82neurotransmitter-gated ion channel clustering (GO:0072578)2.86491959
83regulation of glutamate secretion (GO:0014048)2.84683144
84photoreceptor cell maintenance (GO:0045494)2.84639540
85sympathetic nervous system development (GO:0048485)2.84312798
86neuronal action potential propagation (GO:0019227)2.83986978
87mitochondrial respiratory chain complex assembly (GO:0033108)2.81966734
88protein-cofactor linkage (GO:0018065)2.79650747
89organ growth (GO:0035265)2.79464210
90gamma-aminobutyric acid signaling pathway (GO:0007214)2.78704358
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78675330
92anterograde axon cargo transport (GO:0008089)2.78484019
93neurotransmitter transport (GO:0006836)2.77990001
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77788501
95righting reflex (GO:0060013)2.76346533
96synapse assembly (GO:0007416)2.75678243
97membrane depolarization (GO:0051899)2.75356462
98neuronal action potential (GO:0019228)2.74730478
99layer formation in cerebral cortex (GO:0021819)2.74427750
100positive regulation of action potential (GO:0045760)2.73695167
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73564411
102regulation of synapse organization (GO:0050807)2.72345802
103microtubule depolymerization (GO:0007019)2.72160754
104serotonin receptor signaling pathway (GO:0007210)2.71964648
105ketone body metabolic process (GO:1902224)2.70292295
106cornea development in camera-type eye (GO:0061303)2.70275571
107catecholamine transport (GO:0051937)2.70180116
108neurofilament cytoskeleton organization (GO:0060052)2.70086535
109neuronal ion channel clustering (GO:0045161)2.69575514
110intraciliary transport (GO:0042073)2.69489072
111cochlea development (GO:0090102)2.69046614
112dendritic spine organization (GO:0097061)2.68503334
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.68114541
114inner ear receptor stereocilium organization (GO:0060122)2.67306170
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66459350
116regulation of synaptic vesicle exocytosis (GO:2000300)2.64769457
117gamma-aminobutyric acid transport (GO:0015812)2.64189771
118mesenchymal-epithelial cell signaling (GO:0060638)2.64173213
119glutamate secretion (GO:0014047)2.63602133
120positive regulation of protein homodimerization activity (GO:0090073)2.63440846
121axoneme assembly (GO:0035082)2.63429059
122locomotory exploration behavior (GO:0035641)2.63324768
123inositol phosphate catabolic process (GO:0071545)2.63204151
124cilium assembly (GO:0042384)2.63182891
125dendrite morphogenesis (GO:0048813)2.62925684
126adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62720064
127reflex (GO:0060004)2.62442940
128retina layer formation (GO:0010842)2.61783753
129cilium organization (GO:0044782)2.61665657
130cAMP-mediated signaling (GO:0019933)2.59954868
131innervation (GO:0060384)2.59091479
132genitalia morphogenesis (GO:0035112)2.58749832
133multicellular organismal signaling (GO:0035637)2.58464424
134regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57955090
135positive regulation of dendritic spine development (GO:0060999)2.57379629
136long-term memory (GO:0007616)2.57276236
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56025100
138neural tube formation (GO:0001841)2.55948324
139epithelial cilium movement (GO:0003351)2.51759119
140cytochrome complex assembly (GO:0017004)2.51571724
141preassembly of GPI anchor in ER membrane (GO:0016254)2.50769714
142pancreas development (GO:0031016)2.50243650
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46831306
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.46831306
145NADH dehydrogenase complex assembly (GO:0010257)2.46831306
146cullin deneddylation (GO:0010388)2.46694202
147positive regulation of meiosis (GO:0045836)2.46309225
148auditory receptor cell stereocilium organization (GO:0060088)2.44970517
149GPI anchor metabolic process (GO:0006505)2.41917311
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41798309
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.41798309
152determination of left/right symmetry (GO:0007368)2.40099182
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39992343
154inositol phosphate dephosphorylation (GO:0046855)2.39992343
155short-term memory (GO:0007614)2.38705165
156mannosylation (GO:0097502)2.38693066
157retinal cone cell development (GO:0046549)2.38366568
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.37611145
159piRNA metabolic process (GO:0034587)2.36696760
160spinal cord motor neuron differentiation (GO:0021522)2.36165887
161negative regulation of Rho protein signal transduction (GO:0035024)2.35604611
162fucose catabolic process (GO:0019317)2.34861568
163L-fucose metabolic process (GO:0042354)2.34861568
164L-fucose catabolic process (GO:0042355)2.34861568
165bicarbonate transport (GO:0015701)2.33385750
166positive regulation of mitochondrial fission (GO:0090141)2.32415640
167cilium or flagellum-dependent cell motility (GO:0001539)2.32234452
168neuron fate determination (GO:0048664)2.32035978
169regulation of neurotransmitter uptake (GO:0051580)2.32028507
170regulation of mitochondrial translation (GO:0070129)2.31182259
171smoothened signaling pathway (GO:0007224)2.31002017
172detection of light stimulus involved in sensory perception (GO:0050962)2.29501494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41543903
2GBX2_23144817_ChIP-Seq_PC3_Human4.03872286
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92538224
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75020128
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73890943
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69062546
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.65100923
8TAF15_26573619_Chip-Seq_HEK293_Human2.61977588
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59809088
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48368821
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42203973
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39329332
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.39044102
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.38777962
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36376884
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33585288
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32620573
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32297902
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30109757
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30109757
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22394011
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22235226
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12475429
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.06919915
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99828326
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99642606
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97936416
28P300_19829295_ChIP-Seq_ESCs_Human1.96288294
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.94519180
30REST_21632747_ChIP-Seq_MESCs_Mouse1.94035001
31IGF1R_20145208_ChIP-Seq_DFB_Human1.93293333
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89600653
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85742845
34RNF2_27304074_Chip-Seq_NSC_Mouse1.82819113
35VDR_22108803_ChIP-Seq_LS180_Human1.82545417
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79233114
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76687366
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.76330410
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74962489
40* FUS_26573619_Chip-Seq_HEK293_Human1.69843945
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68625742
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67971148
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67188054
44AR_21572438_ChIP-Seq_LNCaP_Human1.66565961
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65928590
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.64333914
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63372379
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61235099
49SMAD4_21799915_ChIP-Seq_A2780_Human1.60212077
50ZNF274_21170338_ChIP-Seq_K562_Hela1.59234473
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.55983364
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53744009
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.50962501
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49010786
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48777371
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45822007
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.44297861
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42228969
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40926150
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38469371
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.36542448
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.36501304
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35991557
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35991557
65DROSHA_22980978_ChIP-Seq_HELA_Human1.35693603
66* EWS_26573619_Chip-Seq_HEK293_Human1.34794374
67* AR_25329375_ChIP-Seq_VCAP_Human1.34393026
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34116268
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.33532105
70CBP_20019798_ChIP-Seq_JUKART_Human1.32538710
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32538710
72TP53_22573176_ChIP-Seq_HFKS_Human1.31971821
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31393802
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30253160
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29461387
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28838145
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28719950
78P53_22387025_ChIP-Seq_ESCs_Mouse1.27924796
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.27052361
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26720290
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26443745
82HTT_18923047_ChIP-ChIP_STHdh_Human1.24305701
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.24147596
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.23496930
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23149072
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22710922
87RUNX2_22187159_ChIP-Seq_PCA_Human1.22198552
88* STAT3_23295773_ChIP-Seq_U87_Human1.21946616
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21573430
90SOX2_19829295_ChIP-Seq_ESCs_Human1.19393601
91NANOG_19829295_ChIP-Seq_ESCs_Human1.19393601
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19376112
93TCF4_22108803_ChIP-Seq_LS180_Human1.19121997
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.18566549
95* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18042242
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17694687
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17392682
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.16661459
99TP53_18474530_ChIP-ChIP_U2OS_Human1.16276715
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15324297
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14549401
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12509664
103P300_18555785_Chip-Seq_ESCs_Mouse1.12101085
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.11869006
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11808190
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.11186894
107AHR_22903824_ChIP-Seq_MCF-7_Human1.10216917
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08998635
109ER_23166858_ChIP-Seq_MCF-7_Human1.08547913
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.08359559
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08242510
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.07683063
113* TCF4_23295773_ChIP-Seq_U87_Human1.07363098
114JUN_21703547_ChIP-Seq_K562_Human1.07121809
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.06794160
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06714600
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05136581
118* IRF1_19129219_ChIP-ChIP_H3396_Human1.04002083
119* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03568349
120* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03568349
121* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03505503
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03201102
123BCAT_22108803_ChIP-Seq_LS180_Human1.03117517
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03092632
125MYC_18940864_ChIP-ChIP_HL60_Human1.02708255
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02374184
127KDM2B_26808549_Chip-Seq_REH_Human1.01959989
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01123382
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98983355
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97960101
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97470484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58862819
2MP0003878_abnormal_ear_physiology3.55846510
3MP0005377_hearing/vestibular/ear_phenot3.55846510
4MP0005423_abnormal_somatic_nervous3.18563219
5MP0001188_hyperpigmentation2.99239933
6MP0006276_abnormal_autonomic_nervous2.95048766
7MP0000569_abnormal_digit_pigmentation2.85848211
8MP0003635_abnormal_synaptic_transmissio2.82059342
9MP0001968_abnormal_touch/_nociception2.81523521
10MP0002638_abnormal_pupillary_reflex2.61433578
11MP0009745_abnormal_behavioral_response2.56743472
12MP0004270_analgesia2.53386875
13MP0000778_abnormal_nervous_system2.48405309
14MP0004859_abnormal_synaptic_plasticity2.45165780
15MP0005645_abnormal_hypothalamus_physiol2.36506730
16MP0001486_abnormal_startle_reflex2.33706221
17MP0002063_abnormal_learning/memory/cond2.32110510
18MP0002572_abnormal_emotion/affect_behav2.31397493
19MP0001529_abnormal_vocalization2.30475090
20MP0008877_abnormal_DNA_methylation2.29013903
21MP0002102_abnormal_ear_morphology2.22793022
22MP0002734_abnormal_mechanical_nocicepti2.21704700
23MP0002184_abnormal_innervation2.20871763
24MP0003122_maternal_imprinting2.18937057
25MP0002736_abnormal_nociception_after2.18769458
26MP0002064_seizures2.14996849
27MP0002735_abnormal_chemical_nociception2.01843067
28MP0001440_abnormal_grooming_behavior1.98991777
29MP0002272_abnormal_nervous_system1.97405125
30MP0005248_abnormal_Harderian_gland1.96685126
31MP0009379_abnormal_foot_pigmentation1.90905645
32MP0002067_abnormal_sensory_capabilities1.85648332
33MP0002557_abnormal_social/conspecific_i1.85232108
34MP0009046_muscle_twitch1.84089190
35MP0004142_abnormal_muscle_tone1.77502191
36MP0006072_abnormal_retinal_apoptosis1.77354370
37MP0004133_heterotaxia1.74604322
38MP0001905_abnormal_dopamine_level1.71880056
39MP0002733_abnormal_thermal_nociception1.71746069
40MP0004147_increased_porphyrin_level1.69037395
41MP0000566_synostosis1.67808345
42MP0006292_abnormal_olfactory_placode1.66120874
43MP0002876_abnormal_thyroid_physiology1.63760257
44MP0001501_abnormal_sleep_pattern1.63384829
45MP0004742_abnormal_vestibular_system1.60952515
46MP0001502_abnormal_circadian_rhythm1.59557455
47MP0005386_behavior/neurological_phenoty1.58726908
48MP0004924_abnormal_behavior1.58726908
49MP0000372_irregular_coat_pigmentation1.56514349
50MP0003183_abnormal_peptide_metabolism1.53472696
51MP0005646_abnormal_pituitary_gland1.45875808
52MP0002751_abnormal_autonomic_nervous1.45596165
53MP0001970_abnormal_pain_threshold1.41502797
54MP0003195_calcinosis1.38232142
55MP0010386_abnormal_urinary_bladder1.36350808
56MP0005551_abnormal_eye_electrophysiolog1.36086196
57MP0003136_yellow_coat_color1.34808136
58MP0005257_abnormal_intraocular_pressure1.34633416
59MP0002822_catalepsy1.32606485
60MP0002882_abnormal_neuron_morphology1.27609424
61MP0005253_abnormal_eye_physiology1.27304510
62MP0003787_abnormal_imprinting1.26697857
63MP0008872_abnormal_physiological_respon1.25219164
64MP0008058_abnormal_DNA_repair1.24840252
65MP0002653_abnormal_ependyma_morphology1.24319506
66MP0005379_endocrine/exocrine_gland_phen1.23669915
67MP0000026_abnormal_inner_ear1.23185280
68MP0002938_white_spotting1.23057434
69MP0008004_abnormal_stomach_pH1.19865559
70MP0003121_genomic_imprinting1.18880853
71MP0001963_abnormal_hearing_physiology1.18879537
72MP0003011_delayed_dark_adaptation1.17759293
73MP0000955_abnormal_spinal_cord1.17623230
74MP0004811_abnormal_neuron_physiology1.15115869
75MP0002752_abnormal_somatic_nervous1.13578296
76MP0004043_abnormal_pH_regulation1.12008349
77MP0003879_abnormal_hair_cell1.10411478
78MP0000631_abnormal_neuroendocrine_gland1.10300370
79MP0003890_abnormal_embryonic-extraembry1.10299712
80MP0005409_darkened_coat_color1.10137896
81MP0003938_abnormal_ear_development1.07766487
82MP0001485_abnormal_pinna_reflex1.07738429
83MP0002909_abnormal_adrenal_gland1.06890103
84MP0002066_abnormal_motor_capabilities/c1.06332178
85MP0001984_abnormal_olfaction0.98862900
86MP0008995_early_reproductive_senescence0.98265689
87MP0000538_abnormal_urinary_bladder0.97767782
88MP0001986_abnormal_taste_sensitivity0.97491320
89MP0002152_abnormal_brain_morphology0.96881403
90MP0005391_vision/eye_phenotype0.96476182
91MP0001756_abnormal_urination0.95795714
92MP0003119_abnormal_digestive_system0.95150728
93MP0002163_abnormal_gland_morphology0.94947542
94MP0009780_abnormal_chondrocyte_physiolo0.93348620
95MP0008789_abnormal_olfactory_epithelium0.92791323
96MP0002837_dystrophic_cardiac_calcinosis0.92026698
97MP0005394_taste/olfaction_phenotype0.91464209
98MP0005499_abnormal_olfactory_system0.91464209
99MP0000427_abnormal_hair_cycle0.90762545
100MP0001944_abnormal_pancreas_morphology0.90366705
101MP0001299_abnormal_eye_distance/0.88596852
102MP0008569_lethality_at_weaning0.86243261
103MP0000639_abnormal_adrenal_gland0.81791817
104MP0002069_abnormal_eating/drinking_beha0.80411643
105MP0001664_abnormal_digestion0.80277814
106MP0005084_abnormal_gallbladder_morpholo0.79330227
107MP0001661_extended_life_span0.79052973
108MP0001764_abnormal_homeostasis0.78047046
109MP0004885_abnormal_endolymph0.77354132
110MP0000049_abnormal_middle_ear0.75903424
111MP0004085_abnormal_heartbeat0.73016624
112MP0002229_neurodegeneration0.71606760
113MP0005195_abnormal_posterior_eye0.68463450
114MP0002277_abnormal_respiratory_mucosa0.68395137
115MP0003861_abnormal_nervous_system0.68177156
116MP0004145_abnormal_muscle_electrophysio0.67720583
117MP0002234_abnormal_pharynx_morphology0.65354167
118MP0005451_abnormal_body_composition0.65086075
119MP0003385_abnormal_body_wall0.65060673
120MP0003937_abnormal_limbs/digits/tail_de0.64729727
121MP0003137_abnormal_impulse_conducting0.62135643
122MP0004215_abnormal_myocardial_fiber0.61464444
123MP0000015_abnormal_ear_pigmentation0.60022770
124MP0000751_myopathy0.58482191
125MP0005535_abnormal_body_temperature0.56286370
126MP0002116_abnormal_craniofacial_bone0.55041921
127MP0004381_abnormal_hair_follicle0.53233988
128MP0003632_abnormal_nervous_system0.51891791

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77866810
2Febrile seizures (HP:0002373)4.71486867
3Focal seizures (HP:0007359)4.36586077
4Hypothermia (HP:0002045)4.22958529
5Atonic seizures (HP:0010819)4.15000531
6Progressive cerebellar ataxia (HP:0002073)3.70836687
7Absence seizures (HP:0002121)3.61244824
8Decreased central vision (HP:0007663)3.47731986
9Polyphagia (HP:0002591)3.41724789
10Dialeptic seizures (HP:0011146)3.39648023
11Esotropia (HP:0000565)3.34178474
12Increased corneal curvature (HP:0100692)3.28438722
13Keratoconus (HP:0000563)3.28438722
14Epileptic encephalopathy (HP:0200134)3.26760926
15Generalized tonic-clonic seizures (HP:0002069)3.21702918
16Hyperventilation (HP:0002883)3.19915167
17Broad-based gait (HP:0002136)3.12916951
18Visual hallucinations (HP:0002367)3.08527417
19Abnormality of midbrain morphology (HP:0002418)3.04767276
20Molar tooth sign on MRI (HP:0002419)3.04767276
21Myokymia (HP:0002411)2.97090603
22Acute necrotizing encephalopathy (HP:0006965)2.96831111
23Exotropia (HP:0000577)2.93220652
24True hermaphroditism (HP:0010459)2.76774747
25Protruding tongue (HP:0010808)2.75104302
26Pendular nystagmus (HP:0012043)2.74686469
27Fair hair (HP:0002286)2.72625717
28Poor suck (HP:0002033)2.72289579
29Limb dystonia (HP:0002451)2.69916440
30Progressive macrocephaly (HP:0004481)2.67640266
31Drooling (HP:0002307)2.66667870
32Excessive salivation (HP:0003781)2.66667870
33Abnormal hair whorl (HP:0010721)2.63297767
34Intestinal atresia (HP:0011100)2.62230399
35Genital tract atresia (HP:0001827)2.57786999
36Abnormal mitochondria in muscle tissue (HP:0008316)2.56649111
37Attenuation of retinal blood vessels (HP:0007843)2.51452519
38Vaginal atresia (HP:0000148)2.51228098
39Chronic hepatic failure (HP:0100626)2.46623347
40Pancreatic fibrosis (HP:0100732)2.46513636
41Blue irides (HP:0000635)2.46457109
42Concave nail (HP:0001598)2.41255564
43Gait imbalance (HP:0002141)2.39281274
44Pancreatic cysts (HP:0001737)2.37549233
45Increased CSF lactate (HP:0002490)2.35887418
46Abnormality of the renal cortex (HP:0011035)2.35001762
47Abnormal ciliary motility (HP:0012262)2.34619308
48Agitation (HP:0000713)2.33414790
49Failure to thrive in infancy (HP:0001531)2.32063780
50Congenital stationary night blindness (HP:0007642)2.31054802
51Cystic liver disease (HP:0006706)2.28822228
52Nephronophthisis (HP:0000090)2.27771382
53Oligodactyly (hands) (HP:0001180)2.27207702
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.24794433
55Absent/shortened dynein arms (HP:0200106)2.24794433
56Methylmalonic acidemia (HP:0002912)2.23289003
57Hyperglycinemia (HP:0002154)2.23126246
58Narrow nasal bridge (HP:0000446)2.21872376
59Hypoventilation (HP:0002791)2.18769981
60Hepatocellular necrosis (HP:0001404)2.18298302
61Generalized hypopigmentation of hair (HP:0011358)2.17371627
62Medial flaring of the eyebrow (HP:0010747)2.16257487
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.14170322
64Recurrent corneal erosions (HP:0000495)2.13913777
65Poor coordination (HP:0002370)2.12446129
66Abnormality of salivation (HP:0100755)2.11695342
67Lissencephaly (HP:0001339)2.11528976
68Bony spicule pigmentary retinopathy (HP:0007737)2.11156435
69Type II lissencephaly (HP:0007260)2.09511494
70Abnormal eating behavior (HP:0100738)2.09472980
71Alacrima (HP:0000522)2.09121884
72Fetal akinesia sequence (HP:0001989)2.09080513
73Sclerocornea (HP:0000647)2.08381394
74Nephrogenic diabetes insipidus (HP:0009806)2.07934398
75Acute encephalopathy (HP:0006846)2.07628241
76Hypoplasia of the brainstem (HP:0002365)2.07274383
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07274383
78Akinesia (HP:0002304)2.07086305
79Mitochondrial inheritance (HP:0001427)2.07039542
80Hepatic necrosis (HP:0002605)2.06369794
81Severe visual impairment (HP:0001141)2.05070005
82Retinal dysplasia (HP:0007973)2.03088215
83Abolished electroretinogram (ERG) (HP:0000550)2.02934270
84Septo-optic dysplasia (HP:0100842)2.02348534
85Osteomalacia (HP:0002749)2.00828648
86Optic nerve hypoplasia (HP:0000609)1.99195911
87Tubulointerstitial nephritis (HP:0001970)1.98605484
88Lipid accumulation in hepatocytes (HP:0006561)1.96663175
89Morphological abnormality of the middle ear (HP:0008609)1.94785172
90Sleep apnea (HP:0010535)1.94514662
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93987874
92Congenital primary aphakia (HP:0007707)1.91200244
93Optic disc pallor (HP:0000543)1.90868500
94Labial hypoplasia (HP:0000066)1.90822748
953-Methylglutaconic aciduria (HP:0003535)1.90601042
96Volvulus (HP:0002580)1.90498612
97Mixed hearing impairment (HP:0000410)1.90491829
98Postaxial hand polydactyly (HP:0001162)1.89528780
99Occipital encephalocele (HP:0002085)1.88791289
100Absent speech (HP:0001344)1.88651346
101Dry hair (HP:0011359)1.88354008
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.88215247
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87704234
104Specific learning disability (HP:0001328)1.87569279
105Postaxial foot polydactyly (HP:0001830)1.87259495
106Amblyopia (HP:0000646)1.86566075
107Truncal ataxia (HP:0002078)1.86257275
108Hypoplasia of the fovea (HP:0007750)1.86138453
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.86138453
110Increased hepatocellular lipid droplets (HP:0006565)1.86065073
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85628851
112Epileptiform EEG discharges (HP:0011182)1.84441134
113Inability to walk (HP:0002540)1.83824892
114Anterior segment dysgenesis (HP:0007700)1.83677660
115Anencephaly (HP:0002323)1.83671625
116Abnormal respiratory motile cilium physiology (HP:0012261)1.83574815
117Gaze-evoked nystagmus (HP:0000640)1.82965919
118Aplasia involving bones of the extremities (HP:0009825)1.82342836
119Aplasia involving bones of the upper limbs (HP:0009823)1.82342836
120Aplasia of the phalanges of the hand (HP:0009802)1.82342836
121Abnormality of vitamin B metabolism (HP:0004340)1.81714944
122Abnormality of the labia minora (HP:0012880)1.81400726
123Stage 5 chronic kidney disease (HP:0003774)1.80576126
124Abnormality of the renal medulla (HP:0100957)1.80505259
125Hypoplastic pelvis (HP:0008839)1.80177539
126Partial duplication of thumb phalanx (HP:0009944)1.80112084
127Broad foot (HP:0001769)1.79832811
128Conical tooth (HP:0000698)1.79795353
129EEG with generalized epileptiform discharges (HP:0011198)1.79739675
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.79230582
131Preaxial hand polydactyly (HP:0001177)1.79041291
132Narrow forehead (HP:0000341)1.78893977
133Gastrointestinal atresia (HP:0002589)1.78372573
134Male pseudohermaphroditism (HP:0000037)1.77555788
135Renal Fanconi syndrome (HP:0001994)1.77278844
136Preaxial foot polydactyly (HP:0001841)1.77260764
137Methylmalonic aciduria (HP:0012120)1.76958737
138Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76685276
139Retinitis pigmentosa (HP:0000510)1.76199964
140Renal cortical cysts (HP:0000803)1.75641298
141Hypoplastic female external genitalia (HP:0012815)1.74955184
142Mutism (HP:0002300)1.73950417
143Aplasia/Hypoplasia of the lens (HP:0008063)1.73314659
144Decreased lacrimation (HP:0000633)1.73077434
145Abnormality of permanent molar morphology (HP:0011071)1.72843555
146Abnormality of the dental root (HP:0006486)1.72843555
147Taurodontia (HP:0000679)1.72843555
148Stereotypic behavior (HP:0000733)1.72284915
149Congenital sensorineural hearing impairment (HP:0008527)1.72233599
150Psychosis (HP:0000709)1.71533234
151Proximal tubulopathy (HP:0000114)1.69991551
152Median cleft lip (HP:0000161)1.69576060
153Cupped ear (HP:0000378)1.69383349
154Hypsarrhythmia (HP:0002521)1.68918646
155Abnormal rod and cone electroretinograms (HP:0008323)1.67711945
156Abnormality of the axillary hair (HP:0100134)1.67436304
157Abnormality of secondary sexual hair (HP:0009888)1.67436304
158Hemiparesis (HP:0001269)1.67105367
159Poor eye contact (HP:0000817)1.66778716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.65008015
2CASK4.60213367
3MARK14.03077606
4MAP4K23.35262376
5MAPK133.16741384
6MAP2K73.13815122
7UHMK12.76818621
8MAP3K42.71465118
9TNIK2.61879033
10NTRK22.61728876
11WNK32.52681053
12SIK22.47606160
13TRIM282.25160872
14ZAK2.23408367
15MAP3K122.14471624
16PRPF4B2.07734898
17NTRK31.97490402
18BCR1.86212223
19SIK31.83516058
20FGFR21.74871545
21PINK11.70674882
22DYRK21.70126771
23ACVR1B1.69935108
24AKT31.67037510
25PIK3CG1.57299634
26MINK11.52346966
27MAP3K91.51902115
28PNCK1.51507928
29KSR11.42898303
30MUSK1.39920642
31BCKDK1.38205324
32CDK191.36857875
33YES11.35452344
34DAPK21.33599689
35MAP2K41.27660433
36PLK21.27186618
37BMPR1B1.25895336
38STK38L1.24956252
39STK161.20001051
40WNK41.14363405
41DAPK11.14323964
42MAPK151.12449967
43ERBB31.10402219
44OXSR11.05462456
45CDK51.05356007
46DYRK1A1.03230414
47GRK71.02901439
48EPHA41.00644089
49INSRR1.00109855
50FGR0.99452571
51TLK10.97638549
52CAMK2A0.94808367
53PKN10.93404859
54EIF2AK20.92846435
55VRK10.91695813
56IRAK20.91235654
57PLK40.90689456
58ADRBK20.89829385
59TAOK30.89721410
60CSNK1A1L0.89329321
61BMPR20.87191535
62NME10.86723878
63PRKCG0.84209338
64STK30.80500077
65PHKG20.79511066
66PHKG10.79511066
67BRSK20.78841191
68PAK60.78398171
69ADRBK10.77597686
70MAP2K60.77226701
71PRKCE0.76516609
72NUAK10.76084228
73TSSK60.73496701
74CSNK1G20.72854813
75MST40.72168440
76EPHB20.67964231
77STK390.67951944
78MAPK120.67562282
79CSNK1G30.67216334
80PAK30.66922069
81SGK4940.66386584
82SGK2230.66386584
83PLK30.65756247
84SGK20.65051985
85NLK0.64719456
86GRK10.64459995
87CAMKK20.63608295
88MKNK20.63387840
89EPHA30.63113343
90CAMK2B0.63068557
91PRKG10.61359135
92GRK50.59804579
93CSNK1A10.58989223
94LMTK20.58909989
95CDK30.58705580
96SRPK10.56531565
97MAPKAPK50.55157241
98CCNB10.55020755
99MYLK0.54468889
100PIK3CA0.54150439
101PRKACA0.51661386
102CDK180.51004119
103ERBB40.50762010
104NEK60.49975002
105WEE10.49732888
106RPS6KA50.47655745
107MAPK40.46643315
108MKNK10.46584217
109VRK20.45095967
110STK110.44311493
111CSNK1G10.44179750
112SGK10.43765039
113ROCK10.43487961
114NEK10.42896684
115CDK150.40098868
116MAPK90.40089895
117PRKACB0.39906154
118CDK140.39527178
119PRKCZ0.39051439
120FER0.38910958
121TNK20.38850537
122MAP3K60.37426837
123OBSCN0.37055081
124PLK10.37004837
125CDK11A0.36992242
126FES0.36638944
127CSNK1D0.36499215
128DYRK30.36015350
129EIF2AK30.35590781
130PRKCB0.35506556
131CAMK10.35440868
132CAMK2D0.33924709
133BRAF0.33531717
134ROCK20.33441794
135ATM0.33099316
136MAP2K10.32938554
137FGFR10.32269024
138PRKCQ0.31902399

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.42007518
2Oxidative phosphorylation_Homo sapiens_hsa001903.06984890
3Phototransduction_Homo sapiens_hsa047442.79942819
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62250298
5Synaptic vesicle cycle_Homo sapiens_hsa047212.61431406
6Serotonergic synapse_Homo sapiens_hsa047262.57044558
7Olfactory transduction_Homo sapiens_hsa047402.50801255
8Nitrogen metabolism_Homo sapiens_hsa009102.42764708
9GABAergic synapse_Homo sapiens_hsa047272.42249643
10Taste transduction_Homo sapiens_hsa047422.38336758
11Morphine addiction_Homo sapiens_hsa050322.38051532
12Parkinsons disease_Homo sapiens_hsa050122.36493999
13Glutamatergic synapse_Homo sapiens_hsa047242.32453752
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.23884055
15Alzheimers disease_Homo sapiens_hsa050102.19690504
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11322406
17Propanoate metabolism_Homo sapiens_hsa006401.98569898
18Cardiac muscle contraction_Homo sapiens_hsa042601.98050457
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97842661
20Circadian entrainment_Homo sapiens_hsa047131.94486711
21Amphetamine addiction_Homo sapiens_hsa050311.87290654
22Cocaine addiction_Homo sapiens_hsa050301.83526092
23Axon guidance_Homo sapiens_hsa043601.83322255
24RNA polymerase_Homo sapiens_hsa030201.82730413
25Insulin secretion_Homo sapiens_hsa049111.77801813
26Dopaminergic synapse_Homo sapiens_hsa047281.77739769
27Huntingtons disease_Homo sapiens_hsa050161.73937689
28Cholinergic synapse_Homo sapiens_hsa047251.63813004
29Collecting duct acid secretion_Homo sapiens_hsa049661.63725022
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54369536
31Circadian rhythm_Homo sapiens_hsa047101.40214519
32Tryptophan metabolism_Homo sapiens_hsa003801.37720214
33Long-term depression_Homo sapiens_hsa047301.34252797
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34083734
35Selenocompound metabolism_Homo sapiens_hsa004501.33097429
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32748642
37Renin secretion_Homo sapiens_hsa049241.31410543
38Fanconi anemia pathway_Homo sapiens_hsa034601.30289461
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29451037
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27791564
41Calcium signaling pathway_Homo sapiens_hsa040201.26457961
42Vibrio cholerae infection_Homo sapiens_hsa051101.24128390
43Basal transcription factors_Homo sapiens_hsa030221.23470487
44Linoleic acid metabolism_Homo sapiens_hsa005911.22842705
45Fatty acid elongation_Homo sapiens_hsa000621.22221618
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21039027
47Salivary secretion_Homo sapiens_hsa049701.20584462
48Oxytocin signaling pathway_Homo sapiens_hsa049211.19986328
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19691394
50Long-term potentiation_Homo sapiens_hsa047201.16028445
51Folate biosynthesis_Homo sapiens_hsa007901.14985685
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13382727
53Proteasome_Homo sapiens_hsa030501.10610222
54Homologous recombination_Homo sapiens_hsa034401.10440659
55Peroxisome_Homo sapiens_hsa041461.08600639
56Non-homologous end-joining_Homo sapiens_hsa034501.06415224
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06378477
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03892472
59Type II diabetes mellitus_Homo sapiens_hsa049301.02763722
60Mismatch repair_Homo sapiens_hsa034301.00946952
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00454280
62beta-Alanine metabolism_Homo sapiens_hsa004100.98993581
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95792425
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95461214
65Sulfur metabolism_Homo sapiens_hsa009200.94557261
66Gastric acid secretion_Homo sapiens_hsa049710.93947910
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93795606
68Type I diabetes mellitus_Homo sapiens_hsa049400.93457994
69ErbB signaling pathway_Homo sapiens_hsa040120.93261091
70RNA degradation_Homo sapiens_hsa030180.91092279
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.88182120
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87846664
73Gap junction_Homo sapiens_hsa045400.84880524
74cAMP signaling pathway_Homo sapiens_hsa040240.84373651
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83955516
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83217271
77Wnt signaling pathway_Homo sapiens_hsa043100.80437811
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79864604
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79747225
80Chemical carcinogenesis_Homo sapiens_hsa052040.79263013
81Metabolic pathways_Homo sapiens_hsa011000.78762400
82Phagosome_Homo sapiens_hsa041450.77016016
83Caffeine metabolism_Homo sapiens_hsa002320.76132041
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.75077462
85ABC transporters_Homo sapiens_hsa020100.73286056
86Melanogenesis_Homo sapiens_hsa049160.73210957
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72891974
88Vitamin B6 metabolism_Homo sapiens_hsa007500.70745524
89Ribosome_Homo sapiens_hsa030100.70033545
90Retinol metabolism_Homo sapiens_hsa008300.69770683
91Rheumatoid arthritis_Homo sapiens_hsa053230.69703028
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68981916
93Fatty acid metabolism_Homo sapiens_hsa012120.68580167
94Purine metabolism_Homo sapiens_hsa002300.67592527
95Dilated cardiomyopathy_Homo sapiens_hsa054140.66978755
96Ether lipid metabolism_Homo sapiens_hsa005650.65116832
97Sphingolipid metabolism_Homo sapiens_hsa006000.62523586
98GnRH signaling pathway_Homo sapiens_hsa049120.61193995
99Glutathione metabolism_Homo sapiens_hsa004800.60827840
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60184195
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59872169
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59343785
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58782876
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.58527215
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58479760
106Prion diseases_Homo sapiens_hsa050200.57797413
107Butanoate metabolism_Homo sapiens_hsa006500.56955815
108Ras signaling pathway_Homo sapiens_hsa040140.56406106
109MAPK signaling pathway_Homo sapiens_hsa040100.56319210
110Protein export_Homo sapiens_hsa030600.55132663
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.54353445
112Graft-versus-host disease_Homo sapiens_hsa053320.54317902
113Fatty acid degradation_Homo sapiens_hsa000710.54211607
114Hedgehog signaling pathway_Homo sapiens_hsa043400.53992880
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53960379
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53474196
117Alcoholism_Homo sapiens_hsa050340.53238661
118Ovarian steroidogenesis_Homo sapiens_hsa049130.52909274
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52789963
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.51491769
121Nucleotide excision repair_Homo sapiens_hsa034200.50856746
122Pyruvate metabolism_Homo sapiens_hsa006200.50747356
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48086017
124Autoimmune thyroid disease_Homo sapiens_hsa053200.47739040
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47572014
126One carbon pool by folate_Homo sapiens_hsa006700.46704690
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41471150
128Steroid biosynthesis_Homo sapiens_hsa001000.41178647
129African trypanosomiasis_Homo sapiens_hsa051430.40401216
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39683553
131Regulation of autophagy_Homo sapiens_hsa041400.39489333
132Arginine and proline metabolism_Homo sapiens_hsa003300.37730996
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36998961
134Fat digestion and absorption_Homo sapiens_hsa049750.34219249
135Histidine metabolism_Homo sapiens_hsa003400.33389671
136Arginine biosynthesis_Homo sapiens_hsa002200.32006030
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31790120
138Protein digestion and absorption_Homo sapiens_hsa049740.31774382
139Sulfur relay system_Homo sapiens_hsa041220.30181210
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29631233
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.28283520
142Dorso-ventral axis formation_Homo sapiens_hsa043200.27808901
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26910294
144Inositol phosphate metabolism_Homo sapiens_hsa005620.26382772
145Arachidonic acid metabolism_Homo sapiens_hsa005900.22841509
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22273313
147Choline metabolism in cancer_Homo sapiens_hsa052310.21555085
148Estrogen signaling pathway_Homo sapiens_hsa049150.21285845
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20744437
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20567825
151Pancreatic secretion_Homo sapiens_hsa049720.20451346
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19405012
153Oocyte meiosis_Homo sapiens_hsa041140.19176195
154Melanoma_Homo sapiens_hsa052180.16391970
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.15603433

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