POU5F1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)6.34644760
2regulation of germinal center formation (GO:0002634)5.49567688
3heart field specification (GO:0003128)5.44328879
4secondary heart field specification (GO:0003139)5.44328879
5regulation of timing of cell differentiation (GO:0048505)5.06799080
6protein-cofactor linkage (GO:0018065)4.82347432
7exocrine pancreas development (GO:0031017)4.77752371
8DNA double-strand break processing (GO:0000729)4.71866234
9regulation of telomere maintenance via telomerase (GO:0032210)4.71406347
10positive regulation of cardiac muscle cell differentiation (GO:2000727)4.68015622
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66586528
12hindbrain development (GO:0030902)4.46680313
13regulation of development, heterochronic (GO:0040034)4.45375384
14acrosome reaction (GO:0007340)4.42761870
15opioid receptor signaling pathway (GO:0038003)4.33590180
16neuron recognition (GO:0008038)4.27931057
17negative chemotaxis (GO:0050919)4.25178187
18presynaptic membrane organization (GO:0097090)4.19441955
19central nervous system projection neuron axonogenesis (GO:0021952)4.19433379
20nerve growth factor signaling pathway (GO:0038180)4.04596598
21specification of organ identity (GO:0010092)3.99159666
22lung secretory cell differentiation (GO:0061140)3.93472451
23negative regulation of microtubule polymerization (GO:0031115)3.93254043
24positive regulation of CREB transcription factor activity (GO:0032793)3.91169082
25dentate gyrus development (GO:0021542)3.81541539
26regulation of telomere maintenance (GO:0032204)3.81392709
27epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.79040849
28inositol phosphate catabolic process (GO:0071545)3.63448831
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.57255230
30seminiferous tubule development (GO:0072520)3.55429500
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55163069
32central nervous system neuron axonogenesis (GO:0021955)3.52414095
33telomere maintenance via telomerase (GO:0007004)3.50832492
34centriole replication (GO:0007099)3.50681061
35neuron remodeling (GO:0016322)3.49825905
36viral mRNA export from host cell nucleus (GO:0046784)3.38896769
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.33008941
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.33008941
39long term synaptic depression (GO:0060292)3.28374669
40cardiac left ventricle morphogenesis (GO:0003214)3.27139892
41regulation of platelet aggregation (GO:0090330)3.21192544
42negative regulation of axon extension (GO:0030517)3.19481247
43negative regulation of telomere maintenance (GO:0032205)3.19101914
44mitochondrial genome maintenance (GO:0000002)3.18811871
45regulation of protein glycosylation (GO:0060049)3.17012904
46regulation of collateral sprouting (GO:0048670)3.13714758
47long-chain fatty acid biosynthetic process (GO:0042759)3.12874347
48nucleobase biosynthetic process (GO:0046112)3.11141543
49positive regulation of protein homodimerization activity (GO:0090073)3.10235625
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10079343
51ventricular trabecula myocardium morphogenesis (GO:0003222)3.09401478
52endothelial tube morphogenesis (GO:0061154)3.07206027
53morphogenesis of an endothelium (GO:0003159)3.07206027
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06750053
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.06750053
56NADH dehydrogenase complex assembly (GO:0010257)3.06750053
57polyol catabolic process (GO:0046174)3.06650763
58neural tube formation (GO:0001841)3.01344086
59olfactory bulb development (GO:0021772)3.01245985
60DNA deamination (GO:0045006)3.00824619
61microtubule depolymerization (GO:0007019)3.00751847
62heparin biosynthetic process (GO:0030210)2.99524068
63heparin metabolic process (GO:0030202)2.99524068
64replicative senescence (GO:0090399)2.97720478
65spinal cord motor neuron differentiation (GO:0021522)2.96218292
66lung epithelial cell differentiation (GO:0060487)2.93705689
67pyrimidine nucleobase catabolic process (GO:0006208)2.92548306
68negative regulation of B cell proliferation (GO:0030889)2.92477029
69regulation of clathrin-mediated endocytosis (GO:2000369)2.90517582
70neuron maturation (GO:0042551)2.90039903
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.88628958
72positive regulation of cell fate commitment (GO:0010455)2.86101458
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.79841276
74dendrite morphogenesis (GO:0048813)2.77301085
75microtubule nucleation (GO:0007020)2.76877378
76GMP metabolic process (GO:0046037)2.75402482
77mRNA splice site selection (GO:0006376)2.75398357
78negative regulation of meiotic cell cycle (GO:0051447)2.74963287
79microtubule polymerization or depolymerization (GO:0031109)2.72796596
80cerebellum development (GO:0021549)2.70829166
81response to amphetamine (GO:0001975)2.69924475
82protein localization to synapse (GO:0035418)2.68972117
83lung cell differentiation (GO:0060479)2.68644878
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68412345
85presynaptic membrane assembly (GO:0097105)2.65763257
86L-fucose catabolic process (GO:0042355)2.65270143
87fucose catabolic process (GO:0019317)2.65270143
88L-fucose metabolic process (GO:0042354)2.65270143
89response to misfolded protein (GO:0051788)2.63987841
90negative regulation of mRNA processing (GO:0050686)2.63534551
91B cell homeostasis (GO:0001782)2.63400176
92regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62986013
93mitochondrial respiratory chain complex assembly (GO:0033108)2.62209052
94negative regulation of dendrite development (GO:2000171)2.62091034
95purine nucleobase biosynthetic process (GO:0009113)2.61742922
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61719785
97negative regulation of T-helper cell differentiation (GO:0045623)2.61719785
98rRNA catabolic process (GO:0016075)2.58413622
99protein localization to chromosome (GO:0034502)2.54126327
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.52882511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.89325224
2ZNF274_21170338_ChIP-Seq_K562_Hela3.83597561
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.44631658
4IGF1R_20145208_ChIP-Seq_DFB_Human3.32247805
5GBX2_23144817_ChIP-Seq_PC3_Human3.17532287
6EZH2_22144423_ChIP-Seq_EOC_Human2.99992271
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78107649
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64090048
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54431898
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51920974
11TAF15_26573619_Chip-Seq_HEK293_Human2.42422606
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.35810563
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.33604946
14FUS_26573619_Chip-Seq_HEK293_Human2.25002036
15AR_21572438_ChIP-Seq_LNCaP_Human2.16306393
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11807650
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.09694387
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09694387
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05922280
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91639062
21EWS_26573619_Chip-Seq_HEK293_Human1.90797319
22BCAT_22108803_ChIP-Seq_LS180_Human1.79459999
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69719133
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68387017
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.67796981
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64102834
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63435503
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.62780536
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.62380562
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.62151398
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58545586
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57545714
33P300_19829295_ChIP-Seq_ESCs_Human1.56658345
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56574461
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54361453
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50844875
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49754110
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48871734
39AR_25329375_ChIP-Seq_VCAP_Human1.46815270
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46338034
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38104306
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37652639
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.37317047
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35551783
45VDR_22108803_ChIP-Seq_LS180_Human1.35185284
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34359160
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31849115
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31788197
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.31616933
50TP53_22573176_ChIP-Seq_HFKS_Human1.31410758
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30823237
52REST_21632747_ChIP-Seq_MESCs_Mouse1.28228984
53ER_23166858_ChIP-Seq_MCF-7_Human1.28056278
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26047345
55CBP_20019798_ChIP-Seq_JUKART_Human1.25102123
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25102123
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.24768468
58TCF4_23295773_ChIP-Seq_U87_Human1.24270098
59GATA3_26560356_Chip-Seq_TH2_Human1.20942741
60TP53_18474530_ChIP-ChIP_U2OS_Human1.18602760
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17922784
62LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16333065
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14842335
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12868437
65CIITA_25753668_ChIP-Seq_RAJI_Human1.12849783
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.10966897
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10732166
68TP53_16413492_ChIP-PET_HCT116_Human1.10546801
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.09678005
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09649149
71RNF2_27304074_Chip-Seq_NSC_Mouse1.08750981
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08017373
73SOX2_19829295_ChIP-Seq_ESCs_Human1.06115165
74NANOG_19829295_ChIP-Seq_ESCs_Human1.06115165
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05207508
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04755559
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04493499
78TCF4_22108803_ChIP-Seq_LS180_Human1.04134300
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03344715
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.01005984
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99857183
82JUN_21703547_ChIP-Seq_K562_Human0.99095039
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.98480550
84FLI1_21867929_ChIP-Seq_TH2_Mouse0.97748204
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97332365
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.97303931
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.96905697
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96671478
89STAT3_23295773_ChIP-Seq_U87_Human0.96621239
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95291704
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.94103105
92KDM2B_26808549_Chip-Seq_REH_Human0.93716505
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93509454
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93306663
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.93010984
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.91967872
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91435264
98P53_22387025_ChIP-Seq_ESCs_Mouse0.91056910
99RUNX2_22187159_ChIP-Seq_PCA_Human0.89133866
100SMAD4_21799915_ChIP-Seq_A2780_Human0.88295767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.17498992
2MP0008877_abnormal_DNA_methylation3.70751426
3MP0003880_abnormal_central_pattern3.61809239
4MP0005423_abnormal_somatic_nervous3.47654044
5MP0003806_abnormal_nucleotide_metabolis2.95943836
6MP0001986_abnormal_taste_sensitivity2.91108427
7MP0002396_abnormal_hematopoietic_system2.90245635
8MP0003787_abnormal_imprinting2.85061846
9MP0000372_irregular_coat_pigmentation2.84248192
10MP0006072_abnormal_retinal_apoptosis2.77536237
11MP0000778_abnormal_nervous_system2.66291400
12MP0006292_abnormal_olfactory_placode2.63003697
13MP0000015_abnormal_ear_pigmentation2.60961568
14MP0003656_abnormal_erythrocyte_physiolo2.57959639
15MP0005084_abnormal_gallbladder_morpholo2.33639516
16MP0008789_abnormal_olfactory_epithelium2.31412268
17MP0008057_abnormal_DNA_replication2.26043981
18MP0004270_analgesia2.21599666
19MP0003718_maternal_effect2.14061052
20MP0005174_abnormal_tail_pigmentation1.89547447
21MP0005394_taste/olfaction_phenotype1.86460135
22MP0005499_abnormal_olfactory_system1.86460135
23MP0010094_abnormal_chromosome_stability1.81152341
24MP0002653_abnormal_ependyma_morphology1.80231491
25MP0005171_absent_coat_pigmentation1.77478534
26MP0001501_abnormal_sleep_pattern1.76025899
27MP0000371_diluted_coat_color1.68319537
28MP0008872_abnormal_physiological_respon1.65154197
29MP0003635_abnormal_synaptic_transmissio1.63629975
30MP0005551_abnormal_eye_electrophysiolog1.58243863
31MP0005360_urolithiasis1.56929656
32MP0002138_abnormal_hepatobiliary_system1.56152337
33MP0003567_abnormal_fetal_cardiomyocyte1.53635788
34MP0001177_atelectasis1.46556892
35MP0005253_abnormal_eye_physiology1.42800583
36MP0004130_abnormal_muscle_cell1.40528735
37MP0005387_immune_system_phenotype1.23347220
38MP0001790_abnormal_immune_system1.23347220
39MP0001800_abnormal_humoral_immune1.19968241
40MP0001968_abnormal_touch/_nociception1.15591435
41MP0001486_abnormal_startle_reflex1.12319243
42MP0002063_abnormal_learning/memory/cond1.10743204
43MP0009697_abnormal_copulation1.09480738
44MP0008058_abnormal_DNA_repair1.07022823
45MP0002184_abnormal_innervation1.05000343
46MP0002734_abnormal_mechanical_nocicepti1.04140321
47MP0001664_abnormal_digestion1.03344463
48MP0006276_abnormal_autonomic_nervous0.99951140
49MP0002095_abnormal_skin_pigmentation0.94237114
50MP0000685_abnormal_immune_system0.91878739
51MP0000465_gastrointestinal_hemorrhage0.90953599
52MP0002102_abnormal_ear_morphology0.90871335
53MP0005220_abnormal_exocrine_pancreas0.90201500
54MP0001188_hyperpigmentation0.90168287
55MP0002735_abnormal_chemical_nociception0.88787779
56MP0001835_abnormal_antigen_presentation0.87006822
57MP0009745_abnormal_behavioral_response0.86336917
58MP0003303_peritoneal_inflammation0.85453677
59MP0002160_abnormal_reproductive_system0.84852115
60MP0000955_abnormal_spinal_cord0.84760859
61MP0002098_abnormal_vibrissa_morphology0.83352035
62MP0003121_genomic_imprinting0.83070160
63MP0002067_abnormal_sensory_capabilities0.82063817
64MP0002928_abnormal_bile_duct0.81612717
65MP0003724_increased_susceptibility_to0.81144947
66MP0005389_reproductive_system_phenotype0.80473142
67MP0002751_abnormal_autonomic_nervous0.80093973
68MP0002272_abnormal_nervous_system0.80010166
69MP0005503_abnormal_tendon_morphology0.78364402
70MP0008875_abnormal_xenobiotic_pharmacok0.77890002
71MP0002752_abnormal_somatic_nervous0.77790939
72MP0002733_abnormal_thermal_nociception0.76157286
73MP0009053_abnormal_anal_canal0.76021465
74MP0002075_abnormal_coat/hair_pigmentati0.75012486
75MP0002736_abnormal_nociception_after0.73793017
76MP0001919_abnormal_reproductive_system0.73712956
77MP0003633_abnormal_nervous_system0.73299999
78MP0001765_abnormal_ion_homeostasis0.72757695
79MP0001186_pigmentation_phenotype0.72714455
80MP0001663_abnormal_digestive_system0.72611964
81MP0005381_digestive/alimentary_phenotyp0.71825181
82MP0000631_abnormal_neuroendocrine_gland0.71653501
83MP0002882_abnormal_neuron_morphology0.71599867
84MP0000534_abnormal_ureter_morphology0.71374731
85MP0004924_abnormal_behavior0.70807601
86MP0005386_behavior/neurological_phenoty0.70807601
87MP0000490_abnormal_crypts_of0.70393575
88MP0003861_abnormal_nervous_system0.69671585
89MP0008569_lethality_at_weaning0.69279150
90MP0000689_abnormal_spleen_morphology0.67884835
91MP0005397_hematopoietic_system_phenotyp0.67858443
92MP0001545_abnormal_hematopoietic_system0.67858443
93MP0003315_abnormal_perineum_morphology0.65535120
94MP0002234_abnormal_pharynx_morphology0.65143313
95MP0002723_abnormal_immune_serum0.65056580
96MP0010386_abnormal_urinary_bladder0.63976571
97MP0003890_abnormal_embryonic-extraembry0.63882534
98MP0009384_cardiac_valve_regurgitation0.63067331
99MP0000462_abnormal_digestive_system0.62778247
100MP0002452_abnormal_antigen_presenting0.60741229

Predicted human phenotypes

RankGene SetZ-score
1Short chin (HP:0000331)5.13477252
2Focal motor seizures (HP:0011153)5.12107160
3Chromsome breakage (HP:0040012)4.78590449
4Metaphyseal dysplasia (HP:0100255)3.70189532
5Abnormality of chromosome stability (HP:0003220)3.63841702
6Focal seizures (HP:0007359)3.43135986
7Pancreatic fibrosis (HP:0100732)3.37112325
8Exotropia (HP:0000577)3.31502938
9Short tibia (HP:0005736)3.11533566
10Ependymoma (HP:0002888)3.10532827
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.08233647
12Long clavicles (HP:0000890)3.06974059
13Protruding tongue (HP:0010808)3.06443456
14Retinal dysplasia (HP:0007973)2.85588001
15Adactyly (HP:0009776)2.84668639
16Thyroiditis (HP:0100646)2.75782093
17Tubulointerstitial nephritis (HP:0001970)2.73608991
18Hyperventilation (HP:0002883)2.71490553
19Generalized hypopigmentation of hair (HP:0011358)2.70818926
20Severe combined immunodeficiency (HP:0004430)2.70430189
21Limb hypertonia (HP:0002509)2.66305367
22Epileptic encephalopathy (HP:0200134)2.64616478
23Generalized tonic-clonic seizures (HP:0002069)2.59316171
24Visual hallucinations (HP:0002367)2.59295005
25Pancreatic cysts (HP:0001737)2.54123598
26Choroideremia (HP:0001139)2.53399445
27Abnormality of midbrain morphology (HP:0002418)2.51835170
28Molar tooth sign on MRI (HP:0002419)2.51835170
29Abnormal biliary tract physiology (HP:0012439)2.50391768
30Bile duct proliferation (HP:0001408)2.50391768
31Drooling (HP:0002307)2.48513380
32High anterior hairline (HP:0009890)2.47231697
33Dialeptic seizures (HP:0011146)2.45180809
34Generalized myoclonic seizures (HP:0002123)2.43708238
35Volvulus (HP:0002580)2.41738569
36Microvesicular hepatic steatosis (HP:0001414)2.41238931
37Excessive salivation (HP:0003781)2.40343448
38Neonatal respiratory distress (HP:0002643)2.37573762
39Decreased subcutaneous fat (HP:0001002)2.35649722
40Colon cancer (HP:0003003)2.34184281
4111 pairs of ribs (HP:0000878)2.33879141
42Hypothermia (HP:0002045)2.31169550
43Abnormality of lateral ventricle (HP:0030047)2.28631165
44Febrile seizures (HP:0002373)2.27032698
45Status epilepticus (HP:0002133)2.26900830
46Abnormality of chromosome segregation (HP:0002916)2.25762811
47Neoplasm of the heart (HP:0100544)2.25682145
48Lymphangioma (HP:0100764)2.25372443
49Pigmentary retinal degeneration (HP:0001146)2.25310431
50Combined immunodeficiency (HP:0005387)2.24511166
51Genital tract atresia (HP:0001827)2.24487478
52Abnormality of the labia minora (HP:0012880)2.23057201
53Pachygyria (HP:0001302)2.19983764
54Tented upper lip vermilion (HP:0010804)2.19412237
55Fair hair (HP:0002286)2.19365452
56Congenital stationary night blindness (HP:0007642)2.17336341
57Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15394223
58Short 1st metacarpal (HP:0010034)2.15394223
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14857783
60Megalencephaly (HP:0001355)2.13970435
61Broad-based gait (HP:0002136)2.13386238
62Chronic hepatic failure (HP:0100626)2.12792974
63Optic nerve hypoplasia (HP:0000609)2.11932133
64Gastrointestinal stroma tumor (HP:0100723)2.10413055
65Abolished electroretinogram (ERG) (HP:0000550)2.08534134
66Absent speech (HP:0001344)2.08399635
67Prominent nose (HP:0000448)2.07331233
68Renal hypoplasia (HP:0000089)2.07279301
69Facial hemangioma (HP:0000329)2.06518611
703-Methylglutaconic aciduria (HP:0003535)2.05865542
71Microglossia (HP:0000171)2.04761872
72Short palpebral fissure (HP:0012745)2.00245443
73Dyschromatopsia (HP:0007641)1.98811465
74Spontaneous hematomas (HP:0007420)1.98485629
75Skull defect (HP:0001362)1.96680832
76Impaired social interactions (HP:0000735)1.96654206
77Abnormal social behavior (HP:0012433)1.96654206
78Abnormality of the 1st metacarpal (HP:0010009)1.93029701
79Broad alveolar ridges (HP:0000187)1.92794028
80Acute necrotizing encephalopathy (HP:0006965)1.92318650
81Horseshoe kidney (HP:0000085)1.91395799
82Broad ribs (HP:0000885)1.90981298
83Clubbing of toes (HP:0100760)1.90536628
84True hermaphroditism (HP:0010459)1.90110995
85Short 4th metacarpal (HP:0010044)1.88445970
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88445970
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.87101321
88Spinal muscular atrophy (HP:0007269)1.85407958
89Aplastic anemia (HP:0001915)1.85196018
90Poor eye contact (HP:0000817)1.84866837
91Lymphopenia (HP:0001888)1.84666798
92Hypochromic microcytic anemia (HP:0004840)1.84034394
93Oligodactyly (hands) (HP:0001180)1.83394238
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.82885754
95Hemoptysis (HP:0002105)1.82383580
96Recurrent sinusitis (HP:0011108)1.79668328
97Abnormality of the astrocytes (HP:0100707)1.79367975
98Astrocytoma (HP:0009592)1.79367975
99Hypoplastic iliac wings (HP:0002866)1.79162304
100Abnormality of salivation (HP:0100755)1.78942204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.01293758
2CLK14.66900459
3MAPK134.34161819
4CCNB14.15957313
5FRK2.43007255
6TAOK32.33670170
7TNK22.31869737
8CAMKK22.30694466
9NTRK32.11932185
10EPHA41.96763113
11PINK11.93922641
12TRIM281.91637498
13SIK21.89900706
14IRAK21.85329672
15GRK61.80636063
16BCR1.79307975
17SRPK11.75230759
18UHMK11.62260917
19RPS6KA41.54218769
20CAMK41.52056200
21PRKD31.49213071
22IRAK11.47308130
23ERBB31.46960921
24CDK31.42169084
25VRK11.31617658
26DYRK21.28371741
27SYK1.26566541
28STK161.19524995
29PRKCZ1.13548934
30DYRK31.08778343
31MAP3K101.00514335
32CAMK1D0.97261518
33STK380.93346228
34NUAK10.92530896
35MAPK40.91629266
36ADRBK20.90864890
37PKN10.84683650
38CDC70.83476898
39PRKCE0.83284667
40GRK10.83179408
41BTK0.82246912
42PRKD20.77850161
43MINK10.77254239
44BLK0.73339653
45CAMKK10.71385738
46SGK20.70120953
47YES10.69651584
48CSNK1A10.68544500
49MAP4K10.67061521
50PRKD10.66555333
51STK110.64034122
52PRKCH0.63736303
53PLK20.63224251
54NEK20.63066254
55TYK20.62930804
56TAOK10.62075368
57AURKB0.61079086
58PLK30.60121322
59CSF1R0.59697429
60PRKCB0.58088259
61BUB10.56747886
62ATR0.55138550
63PDK10.54984959
64BMPR20.54753963
65RIPK40.53864224
66HIPK20.53268894
67VRK20.53239594
68CAMK2B0.53150588
69RPS6KA60.52737721
70MAPK70.51704480
71MKNK20.50495497
72NTRK20.49962890
73MAP3K20.49076939
74EPHA30.48218948
75LYN0.47921478
76DAPK20.47565026
77MAPKAPK20.47518619
78ROCK10.45213658
79SGK10.44903171
80ILK0.44439256
81TXK0.43915671
82RPS6KC10.43529693
83RPS6KL10.43529693
84CASK0.42188611
85PLK40.41575064
86PAK30.40818399
87ROCK20.38984872
88CAMK2A0.36537912
89FES0.36243844
90INSRR0.35912155
91MAPK80.34968696
92ATM0.33539619
93PIK3CG0.33426517
94PLK10.32878234
95PRKCQ0.32565216
96MAP2K20.32435172
97BRSK20.31625277
98SGK2230.30590545
99SGK4940.30590545
100PRKACA0.29851988

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.93228314
2Non-homologous end-joining_Homo sapiens_hsa034504.73371355
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.75583858
4Homologous recombination_Homo sapiens_hsa034402.48340771
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.47344411
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.38607562
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.13432159
8Asthma_Homo sapiens_hsa053102.02163080
9Nicotine addiction_Homo sapiens_hsa050331.94717617
10RNA polymerase_Homo sapiens_hsa030201.77259481
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77050366
12Steroid biosynthesis_Homo sapiens_hsa001001.76994800
13Primary immunodeficiency_Homo sapiens_hsa053401.73625834
14Phototransduction_Homo sapiens_hsa047441.68047642
15Long-term depression_Homo sapiens_hsa047301.63674843
16Glutamatergic synapse_Homo sapiens_hsa047241.60668361
17Circadian entrainment_Homo sapiens_hsa047131.60590526
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52735028
19Fanconi anemia pathway_Homo sapiens_hsa034601.49818746
20Fatty acid biosynthesis_Homo sapiens_hsa000611.49151734
21Axon guidance_Homo sapiens_hsa043601.44185580
22Allograft rejection_Homo sapiens_hsa053301.43882356
23Autoimmune thyroid disease_Homo sapiens_hsa053201.42534662
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41793566
25Graft-versus-host disease_Homo sapiens_hsa053321.39758244
26Taste transduction_Homo sapiens_hsa047421.36287936
27Amphetamine addiction_Homo sapiens_hsa050311.34645348
28Fatty acid elongation_Homo sapiens_hsa000621.32258040
29Morphine addiction_Homo sapiens_hsa050321.31088528
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26750426
31One carbon pool by folate_Homo sapiens_hsa006701.22710107
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.19560523
33DNA replication_Homo sapiens_hsa030301.18413641
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17578006
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17531699
36GABAergic synapse_Homo sapiens_hsa047271.16441761
37B cell receptor signaling pathway_Homo sapiens_hsa046621.11590131
38Fatty acid metabolism_Homo sapiens_hsa012121.09125666
39Cocaine addiction_Homo sapiens_hsa050301.08699808
40RNA degradation_Homo sapiens_hsa030181.06441970
41Renin secretion_Homo sapiens_hsa049241.03320550
42Proteasome_Homo sapiens_hsa030500.98733241
43Propanoate metabolism_Homo sapiens_hsa006400.94693726
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93618842
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87070765
46Type I diabetes mellitus_Homo sapiens_hsa049400.80324462
47Parkinsons disease_Homo sapiens_hsa050120.79909585
48Salivary secretion_Homo sapiens_hsa049700.76070750
49Olfactory transduction_Homo sapiens_hsa047400.75955308
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75569679
51Serotonergic synapse_Homo sapiens_hsa047260.74989874
52Oxytocin signaling pathway_Homo sapiens_hsa049210.74765555
53Long-term potentiation_Homo sapiens_hsa047200.72844347
54African trypanosomiasis_Homo sapiens_hsa051430.71762282
55Pyrimidine metabolism_Homo sapiens_hsa002400.70146502
56RNA transport_Homo sapiens_hsa030130.69635652
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67971683
58Dorso-ventral axis formation_Homo sapiens_hsa043200.67410686
59Synaptic vesicle cycle_Homo sapiens_hsa047210.67095860
60Antigen processing and presentation_Homo sapiens_hsa046120.65870649
61Spliceosome_Homo sapiens_hsa030400.65653577
62Cholinergic synapse_Homo sapiens_hsa047250.63232395
63Calcium signaling pathway_Homo sapiens_hsa040200.62151326
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61741906
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59221582
66Hedgehog signaling pathway_Homo sapiens_hsa043400.58303165
67mTOR signaling pathway_Homo sapiens_hsa041500.56056801
68Dopaminergic synapse_Homo sapiens_hsa047280.55135482
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54801529
70Inositol phosphate metabolism_Homo sapiens_hsa005620.53552522
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.49509094
72Linoleic acid metabolism_Homo sapiens_hsa005910.48481920
73Wnt signaling pathway_Homo sapiens_hsa043100.47486876
74Gap junction_Homo sapiens_hsa045400.47321923
75Staphylococcus aureus infection_Homo sapiens_hsa051500.46270992
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45861373
77Insulin secretion_Homo sapiens_hsa049110.45452793
78Purine metabolism_Homo sapiens_hsa002300.45126692
79Gastric acid secretion_Homo sapiens_hsa049710.42727838
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41324434
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41199171
82Caffeine metabolism_Homo sapiens_hsa002320.40484418
83Alzheimers disease_Homo sapiens_hsa050100.40298425
84Epstein-Barr virus infection_Homo sapiens_hsa051690.39611692
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38800370
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38318051
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37508725
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37248443
89Oocyte meiosis_Homo sapiens_hsa041140.36346491
90Ovarian steroidogenesis_Homo sapiens_hsa049130.35604481
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34538117
92Oxidative phosphorylation_Homo sapiens_hsa001900.31765649
93Mismatch repair_Homo sapiens_hsa034300.31700082
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31092302
95Base excision repair_Homo sapiens_hsa034100.30370162
96Vitamin digestion and absorption_Homo sapiens_hsa049770.29788892
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29329368
98Rheumatoid arthritis_Homo sapiens_hsa053230.26654984
99Ras signaling pathway_Homo sapiens_hsa040140.25830731
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.24099633

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