POU5F1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of execution phase of apoptosis (GO:1900118)6.93791004
2positive regulation of cAMP-mediated signaling (GO:0043950)5.36599944
3regulation of meiosis I (GO:0060631)4.69508577
4proteasome assembly (GO:0043248)4.54048589
5pantothenate metabolic process (GO:0015939)4.43845807
6RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.27342323
7T cell migration (GO:0072678)4.26840870
8protein deneddylation (GO:0000338)4.22958554
9synapsis (GO:0007129)3.99365218
10multicellular organismal aging (GO:0010259)3.93251318
11regulation of gene silencing by RNA (GO:0060966)3.84387296
12regulation of posttranscriptional gene silencing (GO:0060147)3.84387296
13regulation of gene silencing by miRNA (GO:0060964)3.84387296
14leukotriene biosynthetic process (GO:0019370)3.65338826
15regulation of helicase activity (GO:0051095)3.61230236
16gonadal mesoderm development (GO:0007506)3.61180872
17positive regulation of T cell cytokine production (GO:0002726)3.60888350
18resolution of meiotic recombination intermediates (GO:0000712)3.59418555
19piRNA metabolic process (GO:0034587)3.58389158
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55001145
21single strand break repair (GO:0000012)3.51790733
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46677002
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.46677002
24DNA deamination (GO:0045006)3.42134296
25positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.34037308
26regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.34037308
27replication fork processing (GO:0031297)3.26642687
28chaperone-mediated protein transport (GO:0072321)3.22747455
29DNA double-strand break processing (GO:0000729)3.20037751
30CENP-A containing nucleosome assembly (GO:0034080)3.19623947
31chromatin remodeling at centromere (GO:0031055)3.19383355
32positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.16734867
33regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.16734867
34regulation of DNA endoreduplication (GO:0032875)3.16543281
35positive regulation of mRNA 3-end processing (GO:0031442)3.13998810
36photoreceptor cell maintenance (GO:0045494)3.09163786
37male meiosis (GO:0007140)3.09065210
38histone H2A acetylation (GO:0043968)3.06520641
39regulation of glucokinase activity (GO:0033131)3.06359275
40regulation of hexokinase activity (GO:1903299)3.06359275
41histone exchange (GO:0043486)3.04920020
42kinetochore organization (GO:0051383)3.02484007
43male meiosis I (GO:0007141)3.00357279
44Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99031463
45negative regulation of meiosis (GO:0045835)2.98795509
46DNA replication-dependent nucleosome assembly (GO:0006335)2.95442634
47DNA replication-dependent nucleosome organization (GO:0034723)2.95442634
48kinetochore assembly (GO:0051382)2.95411202
49double-strand break repair via homologous recombination (GO:0000724)2.94408729
50gene silencing by RNA (GO:0031047)2.91861233
51DNA replication-independent nucleosome organization (GO:0034724)2.90671516
52DNA replication-independent nucleosome assembly (GO:0006336)2.90671516
53DNA demethylation (GO:0080111)2.89639933
54positive regulation of mRNA catabolic process (GO:0061014)2.89051572
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87922414
56actin nucleation (GO:0045010)2.87821901
57recombinational repair (GO:0000725)2.87634238
58regulation of chromatin silencing (GO:0031935)2.86797708
59regulation of mitochondrial translation (GO:0070129)2.86068890
60regulation of mRNA 3-end processing (GO:0031440)2.84493554
61misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.83400890
62multicellular organismal movement (GO:0050879)2.82466404
63musculoskeletal movement (GO:0050881)2.82466404
64positive regulation of mRNA processing (GO:0050685)2.81499183
65cell fate commitment involved in formation of primary germ layer (GO:0060795)2.80306864
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80017362
67coenzyme A biosynthetic process (GO:0015937)2.79776991
68response to misfolded protein (GO:0051788)2.76392979
69DNA dealkylation (GO:0035510)2.75172936
70regulation of cAMP-mediated signaling (GO:0043949)2.75139112
71RNA phosphodiester bond hydrolysis (GO:0090501)2.72294913
72ribonucleoprotein complex disassembly (GO:0032988)2.71893153
73cholesterol biosynthetic process (GO:0006695)2.70032584
74female gonad development (GO:0008585)2.68921934
75cochlea development (GO:0090102)2.67506391
76cytolysis (GO:0019835)2.66647678
77peptidyl-arginine omega-N-methylation (GO:0035247)2.64839934
78positive regulation of mRNA metabolic process (GO:1903313)2.63628662
79regulation of execution phase of apoptosis (GO:1900117)2.62713341
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.62189717
81negative T cell selection (GO:0043383)2.62052215
82positive regulation of interleukin-2 production (GO:0032743)2.61988208
83ncRNA 3-end processing (GO:0043628)2.61780593
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61672550
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.61672550
86regulation of translation, ncRNA-mediated (GO:0045974)2.61672550
87maturation of 5.8S rRNA (GO:0000460)2.60898011
88histone arginine methylation (GO:0034969)2.58688945
89histone mRNA metabolic process (GO:0008334)2.57990331
90mitotic spindle checkpoint (GO:0071174)2.54909216
91interferon-gamma production (GO:0032609)2.53871869
92protein complex localization (GO:0031503)2.52926558
93mitotic sister chromatid cohesion (GO:0007064)2.51314655
94neuronal stem cell maintenance (GO:0097150)2.50630753
95cullin deneddylation (GO:0010388)2.50422885
96regulation of mRNA catabolic process (GO:0061013)2.50058735
97metallo-sulfur cluster assembly (GO:0031163)2.49328725
98iron-sulfur cluster assembly (GO:0016226)2.49328725
99water-soluble vitamin biosynthetic process (GO:0042364)2.49269681
100RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.48964059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78226085
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.42094855
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.24291220
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02590618
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87031218
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.83896719
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.77280340
8ZNF274_21170338_ChIP-Seq_K562_Hela2.73205305
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67934256
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.67833091
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55608510
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47884870
13ELK1_19687146_ChIP-ChIP_HELA_Human2.38440910
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30695935
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27320769
16VDR_22108803_ChIP-Seq_LS180_Human2.27003302
17VDR_23849224_ChIP-Seq_CD4+_Human2.22967728
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21790909
19IGF1R_20145208_ChIP-Seq_DFB_Human2.21633785
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18545800
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16146953
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.09894275
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09760891
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04816725
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02167290
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.95393399
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91489221
28MYC_18940864_ChIP-ChIP_HL60_Human1.88110874
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82042619
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.79406612
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71627430
32IRF1_19129219_ChIP-ChIP_H3396_Human1.70445750
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64413898
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63276320
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62542154
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.56511525
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56074472
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.54081694
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52744206
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52133781
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51101363
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.49644515
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47540242
44FOXP3_21729870_ChIP-Seq_TREG_Human1.45518882
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44986962
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43153140
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42943274
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41663890
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35136715
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34160472
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32591967
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32053487
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32053487
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32053487
55EWS_26573619_Chip-Seq_HEK293_Human1.30627998
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.25619508
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.24423950
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.22601022
59FUS_26573619_Chip-Seq_HEK293_Human1.19440270
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18030442
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.15833141
62P300_19829295_ChIP-Seq_ESCs_Human1.13943354
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13270411
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13005229
65TAF15_26573619_Chip-Seq_HEK293_Human1.12398680
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10334903
67AR_20517297_ChIP-Seq_VCAP_Human1.10223732
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09141985
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07576998
70DCP1A_22483619_ChIP-Seq_HELA_Human1.07246850
71BCAT_22108803_ChIP-Seq_LS180_Human1.07091992
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06111675
73GATA3_27048872_Chip-Seq_THYMUS_Human1.03267803
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02844207
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02519867
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02202605
77GATA3_26560356_Chip-Seq_TH2_Human1.01733203
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01146457
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00725268
80E2F7_22180533_ChIP-Seq_HELA_Human0.99417704
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98741084
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98185697
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97764458
84GBX2_23144817_ChIP-Seq_PC3_Human0.97614969
85ER_23166858_ChIP-Seq_MCF-7_Human0.96454743
86GABP_19822575_ChIP-Seq_HepG2_Human0.95937998
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93351402
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93260889
89* TP53_22573176_ChIP-Seq_HFKS_Human0.92819370
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92376808
91CBP_20019798_ChIP-Seq_JUKART_Human0.92376808
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92008965
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91520214
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88345735
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88176463
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86665432
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86602278
98AR_21572438_ChIP-Seq_LNCaP_Human0.86487764
99CIITA_25753668_ChIP-Seq_RAJI_Human0.85762866
100NANOG_19829295_ChIP-Seq_ESCs_Human0.85745915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.63749780
2MP0002653_abnormal_ependyma_morphology4.47822518
3MP0005171_absent_coat_pigmentation4.35793985
4MP0008877_abnormal_DNA_methylation3.47865924
5MP0005671_abnormal_response_to3.20183378
6MP0008057_abnormal_DNA_replication3.11089998
7MP0003878_abnormal_ear_physiology3.00387866
8MP0005377_hearing/vestibular/ear_phenot3.00387866
9MP0006072_abnormal_retinal_apoptosis2.66332248
10MP0003111_abnormal_nucleus_morphology2.64208584
11MP0008789_abnormal_olfactory_epithelium2.56932875
12MP0003787_abnormal_imprinting2.45400945
13MP0010094_abnormal_chromosome_stability2.45034414
14MP0000372_irregular_coat_pigmentation2.38594443
15MP0003045_fibrosis2.19608400
16MP0001661_extended_life_span2.07978200
17MP0005499_abnormal_olfactory_system2.00226610
18MP0005394_taste/olfaction_phenotype2.00226610
19MP0008058_abnormal_DNA_repair1.99634241
20MP0005645_abnormal_hypothalamus_physiol1.99242012
21MP0001984_abnormal_olfaction1.93489263
22MP0003786_premature_aging1.90176904
23MP0009697_abnormal_copulation1.86929737
24MP0005253_abnormal_eye_physiology1.71454367
25MP0002938_white_spotting1.70799217
26MP0002163_abnormal_gland_morphology1.68583738
27MP0003136_yellow_coat_color1.68233188
28MP0002928_abnormal_bile_duct1.67782423
29MP0003252_abnormal_bile_duct1.64948004
30MP0008995_early_reproductive_senescence1.63381404
31MP0002095_abnormal_skin_pigmentation1.60815892
32MP0005379_endocrine/exocrine_gland_phen1.58816824
33MP0003077_abnormal_cell_cycle1.57635591
34MP0003866_abnormal_defecation1.56322032
35MP0003890_abnormal_embryonic-extraembry1.56218554
36MP0003763_abnormal_thymus_physiology1.52205875
37MP0001485_abnormal_pinna_reflex1.47729213
38MP0005551_abnormal_eye_electrophysiolog1.41003865
39MP0010368_abnormal_lymphatic_system1.40827472
40MP0004133_heterotaxia1.39668578
41MP0003121_genomic_imprinting1.39351837
42MP0003693_abnormal_embryo_hatching1.39201306
43MP0004957_abnormal_blastocyst_morpholog1.33374271
44MP0002736_abnormal_nociception_after1.27147990
45MP0008932_abnormal_embryonic_tissue1.22843702
46MP0002009_preneoplasia1.22513286
47MP0001529_abnormal_vocalization1.16471545
48MP0002168_other_aberrant_phenotype1.12926996
49MP0004134_abnormal_chest_morphology1.11996123
50MP0003195_calcinosis1.10845700
51MP0000749_muscle_degeneration1.09670939
52MP0005075_abnormal_melanosome_morpholog1.06773693
53MP0009785_altered_susceptibility_to1.05979363
54MP0004215_abnormal_myocardial_fiber1.05366213
55MP0002210_abnormal_sex_determination1.03884682
56MP0001730_embryonic_growth_arrest1.03847936
57MP0009703_decreased_birth_body1.02408272
58MP0002233_abnormal_nose_morphology1.00549249
59MP0001929_abnormal_gametogenesis0.99013079
60MP0003567_abnormal_fetal_cardiomyocyte0.97852620
61MP0003937_abnormal_limbs/digits/tail_de0.97844991
62MP0005187_abnormal_penis_morphology0.97230390
63MP0004197_abnormal_fetal_growth/weight/0.96238690
64MP0010307_abnormal_tumor_latency0.95722556
65MP0005332_abnormal_amino_acid0.95598086
66MP0002084_abnormal_developmental_patter0.95158451
67MP0004381_abnormal_hair_follicle0.94320112
68MP0008872_abnormal_physiological_respon0.92155393
69MP0008961_abnormal_basal_metabolism0.91050118
70MP0003122_maternal_imprinting0.89790573
71MP0005220_abnormal_exocrine_pancreas0.89622536
72MP0004147_increased_porphyrin_level0.89181608
73MP0002127_abnormal_cardiovascular_syste0.85930499
74MP0001177_atelectasis0.83945740
75MP0008770_decreased_survivor_rate0.83712501
76MP0000647_abnormal_sebaceous_gland0.83694887
77MP0002166_altered_tumor_susceptibility0.77189806
78MP0005395_other_phenotype0.76848451
79MP0000653_abnormal_sex_gland0.72629099
80MP0001764_abnormal_homeostasis0.71248412
81MP0001119_abnormal_female_reproductive0.69992317
82MP0000733_abnormal_muscle_development0.69757286
83MP0004185_abnormal_adipocyte_glucose0.69430271
84MP0005380_embryogenesis_phenotype0.69272815
85MP0001672_abnormal_embryogenesis/_devel0.69272815
86MP0005670_abnormal_white_adipose0.68706951
87MP0000350_abnormal_cell_proliferation0.68678611
88MP0001145_abnormal_male_reproductive0.68044717
89MP0003698_abnormal_male_reproductive0.67642719
90MP0003984_embryonic_growth_retardation0.67104007
91MP0002088_abnormal_embryonic_growth/wei0.65708999
92MP0010352_gastrointestinal_tract_polyps0.64661052
93MP0005647_abnormal_sex_gland0.63688325
94MP0006035_abnormal_mitochondrial_morpho0.63392829
95MP0000703_abnormal_thymus_morphology0.63158216
96MP0002085_abnormal_embryonic_tissue0.59453321
97MP0002019_abnormal_tumor_incidence0.59262945
98MP0005391_vision/eye_phenotype0.58919552
99MP0001919_abnormal_reproductive_system0.58537202
100MP0002080_prenatal_lethality0.57603939

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)4.55149289
2White forelock (HP:0002211)3.87020377
3Multiple enchondromatosis (HP:0005701)3.78391258
4Colon cancer (HP:0003003)3.78101142
5Aplastic anemia (HP:0001915)3.71948951
6Rhabdomyosarcoma (HP:0002859)3.50622971
7T lymphocytopenia (HP:0005403)3.37464280
8IgM deficiency (HP:0002850)3.23949553
9Abnormality of the labia minora (HP:0012880)3.16917038
10Patchy hypopigmentation of hair (HP:0011365)3.12313803
11Neonatal respiratory distress (HP:0002643)3.05755804
12Intestinal atresia (HP:0011100)3.04161536
13Hypoproteinemia (HP:0003075)3.00540180
14Chorioretinal atrophy (HP:0000533)3.00246749
15Congenital sensorineural hearing impairment (HP:0008527)2.95386784
16Male infertility (HP:0003251)2.94318386
17Hyperglycinemia (HP:0002154)2.94067771
18Hyperalaninemia (HP:0003348)2.88406474
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88406474
20Abnormality of alanine metabolism (HP:0010916)2.88406474
21Ependymoma (HP:0002888)2.87847251
22Neoplasm of striated muscle (HP:0009728)2.86021413
23Horizontal nystagmus (HP:0000666)2.82044172
24Abnormality of serine family amino acid metabolism (HP:0010894)2.81439621
25Abnormality of glycine metabolism (HP:0010895)2.81439621
26Abnormality of T cell number (HP:0011839)2.79818962
27Aqueductal stenosis (HP:0002410)2.78832369
28Hypophosphatemic rickets (HP:0004912)2.77632183
29Generalized aminoaciduria (HP:0002909)2.74154404
30Hyperglycinuria (HP:0003108)2.67046146
31Methylmalonic acidemia (HP:0002912)2.54982286
32Urinary urgency (HP:0000012)2.54359272
33Glioma (HP:0009733)2.48483408
34Neoplasm of the oral cavity (HP:0100649)2.43004757
35Polydipsia (HP:0001959)2.41250266
36Abnormal drinking behavior (HP:0030082)2.41250266
37Medial flaring of the eyebrow (HP:0010747)2.39853678
38Abnormality of the parathyroid morphology (HP:0011766)2.38448132
39Congenital primary aphakia (HP:0007707)2.38011916
40Absent radius (HP:0003974)2.31127992
41Abnormality of the costochondral junction (HP:0000919)2.28471104
42Progressive inability to walk (HP:0002505)2.26395210
43Gait imbalance (HP:0002141)2.19395615
44Hypoplasia of the iris (HP:0007676)2.18723047
45Absent forearm bone (HP:0003953)2.15385233
46Aplasia involving forearm bones (HP:0009822)2.15385233
47Stomatitis (HP:0010280)2.14944831
48Hypoplasia of the thymus (HP:0000778)2.12382184
49Nephrogenic diabetes insipidus (HP:0009806)2.10222897
50Tubular atrophy (HP:0000092)2.10026606
51Abnormality of midbrain morphology (HP:0002418)2.09978693
52Molar tooth sign on MRI (HP:0002419)2.09978693
53Abolished electroretinogram (ERG) (HP:0000550)2.09085406
54Abnormality of serum amino acid levels (HP:0003112)2.08429749
55Abnormal hair whorl (HP:0010721)2.06913874
56Medulloblastoma (HP:0002885)2.06113157
57Small hand (HP:0200055)2.05092948
58Pancytopenia (HP:0001876)2.05014054
59Abnormality of the astrocytes (HP:0100707)2.04602097
60Astrocytoma (HP:0009592)2.04602097
61Thyroiditis (HP:0100646)2.02335329
62Delayed puberty (HP:0000823)2.02253532
63Chronic bronchitis (HP:0004469)2.02098200
64Vertebral arch anomaly (HP:0008438)2.00411357
65Prominent metopic ridge (HP:0005487)1.99952974
66Exocrine pancreatic insufficiency (HP:0001738)1.99341430
67Poor coordination (HP:0002370)1.98818826
68Recurrent corneal erosions (HP:0000495)1.98411651
69Methylmalonic aciduria (HP:0012120)1.94128131
70Tubulointerstitial nephritis (HP:0001970)1.93223431
71Absent thumb (HP:0009777)1.91679529
72Pendular nystagmus (HP:0012043)1.90525645
73Type I diabetes mellitus (HP:0100651)1.88129227
74Lymphopenia (HP:0001888)1.87968551
75Abnormality of sulfur amino acid metabolism (HP:0004339)1.87459829
76Abnormal mitochondria in muscle tissue (HP:0008316)1.87063576
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86452081
78Increased serum lactate (HP:0002151)1.86297235
79Clumsiness (HP:0002312)1.85498993
80Amyotrophic lateral sclerosis (HP:0007354)1.85054363
81IgG deficiency (HP:0004315)1.84358264
82Ectopic kidney (HP:0000086)1.83779767
83Abnormality of chromosome stability (HP:0003220)1.81307405
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81083792
85Prostate neoplasm (HP:0100787)1.80033368
86Depressed nasal tip (HP:0000437)1.79481757
87Agnosia (HP:0010524)1.79297998
88Bilateral microphthalmos (HP:0007633)1.77706345
89Premature graying of hair (HP:0002216)1.72125667
90Adactyly (HP:0009776)1.71434784
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.70489585
92Tented upper lip vermilion (HP:0010804)1.70351206
93Abnormality of the metopic suture (HP:0005556)1.69885864
94Specific learning disability (HP:0001328)1.69769794
95Facial diplegia (HP:0001349)1.69499738
96Polyuria (HP:0000103)1.68760884
97Portal hypertension (HP:0001409)1.67927324
98Prominent nose (HP:0000448)1.66596484
99Progressive cerebellar ataxia (HP:0002073)1.66554572
100Hemivertebrae (HP:0002937)1.65400238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.47183393
2NME13.19506417
3MAP4K13.18634833
4STK38L2.67393707
5ACVR1B2.53045435
6BCR2.49140130
7WNK32.48424244
8KDR2.44968373
9TRIM282.44523747
10MST42.22671784
11ZAK2.21118460
12ADRBK22.09924329
13SCYL21.93545462
14TEC1.90820604
15STK391.89772989
16STK241.89482451
17MUSK1.88105936
18MKNK21.82080547
19BMPR1B1.80201986
20WNK41.72379402
21LMTK21.71813671
22MKNK11.71033001
23PAK31.56505153
24AKT31.55180235
25VRK21.51491260
26EIF2AK31.40026139
27BRD41.35791588
28MAP3K41.35421119
29BRSK21.32964769
30CSNK1G11.29945037
31TAOK31.29739538
32NLK1.29191986
33SRPK11.26893299
34TAF11.22836340
35OXSR11.22779362
36DYRK31.19188765
37MAP3K51.17768609
38TTK1.17621634
39PLK41.14571268
40CHEK21.12509144
41VRK11.10091066
42MAP4K21.08210159
43TESK21.02260562
44CSNK1G30.96203387
45CDC70.95182629
46BRSK10.91962443
47MAPKAPK30.91051114
48CSNK1G20.87535553
49CCNB10.86592014
50PBK0.85432658
51ITK0.84722154
52WEE10.84258906
53PLK30.83852430
54ATR0.82688824
55PLK10.79269359
56PASK0.76205472
57PRKCQ0.76106738
58NEK60.75002261
59MAP3K70.73942738
60TNIK0.70866704
61STK30.68609885
62TAOK10.67957492
63CDK190.67149398
64MELK0.67126652
65ATM0.64521706
66WNK10.62690801
67GRK60.61203045
68CSNK1A1L0.61123072
69SIK30.60365759
70TSSK60.59109886
71PRKD30.57495917
72PIM10.55495001
73STK100.54441209
74ERBB30.52059410
75PLK20.49466289
76CHEK10.49366352
77DYRK1A0.46634022
78INSRR0.46557643
79MAP2K70.45981837
80MAP3K100.44165574
81NUAK10.43141200
82RAF10.42795629
83GRK10.42664185
84CAMK40.42526549
85FGFR20.42125799
86DYRK20.38276441
87CDK60.36445543
88CDK40.35666048
89PAK60.35443078
90CSNK1A10.34344730
91MST1R0.33504206
92LCK0.32702882
93MAPK130.31967455
94CSNK2A20.31453675
95MAPK110.30188448
96BUB10.29941613
97YES10.29833233
98CSNK2A10.28503906
99IGF1R0.28058034
100CDK80.26905855

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.86557310
2Selenocompound metabolism_Homo sapiens_hsa004504.37333986
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.73130215
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.72971953
5Steroid biosynthesis_Homo sapiens_hsa001003.15768761
6Proteasome_Homo sapiens_hsa030503.12984268
7RNA polymerase_Homo sapiens_hsa030202.82991122
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48305337
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36523102
10Basal transcription factors_Homo sapiens_hsa030222.20814023
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12528796
12RNA degradation_Homo sapiens_hsa030182.07368832
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06839519
14RNA transport_Homo sapiens_hsa030131.99725539
15Fanconi anemia pathway_Homo sapiens_hsa034601.97240758
16T cell receptor signaling pathway_Homo sapiens_hsa046601.86615063
17Spliceosome_Homo sapiens_hsa030401.77490912
18Non-homologous end-joining_Homo sapiens_hsa034501.76466715
19Homologous recombination_Homo sapiens_hsa034401.70741247
20DNA replication_Homo sapiens_hsa030301.66961913
21Base excision repair_Homo sapiens_hsa034101.66752960
22Mismatch repair_Homo sapiens_hsa034301.64991950
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52829664
24mRNA surveillance pathway_Homo sapiens_hsa030151.41564341
25Cell cycle_Homo sapiens_hsa041101.40231662
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35548100
27Nitrogen metabolism_Homo sapiens_hsa009101.33215364
28Folate biosynthesis_Homo sapiens_hsa007901.24075470
29One carbon pool by folate_Homo sapiens_hsa006701.20217358
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19210778
31Antigen processing and presentation_Homo sapiens_hsa046121.17603669
32Propanoate metabolism_Homo sapiens_hsa006401.17354149
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14521470
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09998255
35Protein export_Homo sapiens_hsa030601.07149934
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05331142
37Oocyte meiosis_Homo sapiens_hsa041141.03847432
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98062755
39Glutathione metabolism_Homo sapiens_hsa004800.86686333
40Pyrimidine metabolism_Homo sapiens_hsa002400.86415532
41Nucleotide excision repair_Homo sapiens_hsa034200.84215100
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83760844
43Hematopoietic cell lineage_Homo sapiens_hsa046400.83630982
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83229326
45Oxidative phosphorylation_Homo sapiens_hsa001900.82723936
46Regulation of autophagy_Homo sapiens_hsa041400.80291342
47Purine metabolism_Homo sapiens_hsa002300.80202767
48Lysine degradation_Homo sapiens_hsa003100.78815572
49Vitamin B6 metabolism_Homo sapiens_hsa007500.75389340
50Huntingtons disease_Homo sapiens_hsa050160.74462909
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74354977
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73069613
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70995584
54Butanoate metabolism_Homo sapiens_hsa006500.69834036
55Parkinsons disease_Homo sapiens_hsa050120.68375035
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67699580
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.60820081
58Phototransduction_Homo sapiens_hsa047440.60122273
59Collecting duct acid secretion_Homo sapiens_hsa049660.59976955
60Notch signaling pathway_Homo sapiens_hsa043300.59905181
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58029447
62Caffeine metabolism_Homo sapiens_hsa002320.54326935
63Systemic lupus erythematosus_Homo sapiens_hsa053220.48838282
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46821778
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.45599385
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.45379189
67Metabolic pathways_Homo sapiens_hsa011000.42645130
68p53 signaling pathway_Homo sapiens_hsa041150.40827758
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40453710
70Biosynthesis of amino acids_Homo sapiens_hsa012300.40263817
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40017397
72Alcoholism_Homo sapiens_hsa050340.39421158
73Glycerolipid metabolism_Homo sapiens_hsa005610.39276187
74Peroxisome_Homo sapiens_hsa041460.38990590
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.35089170
76Taste transduction_Homo sapiens_hsa047420.34403736
77Nicotine addiction_Homo sapiens_hsa050330.32211891
78Arachidonic acid metabolism_Homo sapiens_hsa005900.32119150
79Tight junction_Homo sapiens_hsa045300.31449659
80Legionellosis_Homo sapiens_hsa051340.28802073
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27571499
82Fatty acid metabolism_Homo sapiens_hsa012120.27233778
83Retinol metabolism_Homo sapiens_hsa008300.27089644
84Epstein-Barr virus infection_Homo sapiens_hsa051690.27042816
85TGF-beta signaling pathway_Homo sapiens_hsa043500.27042124
86Carbon metabolism_Homo sapiens_hsa012000.26933271
87Vitamin digestion and absorption_Homo sapiens_hsa049770.26257674
88Adherens junction_Homo sapiens_hsa045200.25726400
89Measles_Homo sapiens_hsa051620.25433275
90Shigellosis_Homo sapiens_hsa051310.23828427
91Hippo signaling pathway_Homo sapiens_hsa043900.23417301
92Wnt signaling pathway_Homo sapiens_hsa043100.17919808
93Ether lipid metabolism_Homo sapiens_hsa005650.17380605
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16655144
95Herpes simplex infection_Homo sapiens_hsa051680.16409432
96Viral carcinogenesis_Homo sapiens_hsa052030.16103610
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15511966
98ABC transporters_Homo sapiens_hsa020100.15394567
99N-Glycan biosynthesis_Homo sapiens_hsa005100.14597142
100Fatty acid degradation_Homo sapiens_hsa000710.14512554

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