POU4F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)9.48592425
2neurofilament cytoskeleton organization (GO:0060052)8.27162436
3detection of temperature stimulus involved in sensory perception (GO:0050961)8.16522178
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)8.16522178
5detection of temperature stimulus (GO:0016048)7.56037731
6negative regulation of calcium ion transport into cytosol (GO:0010523)7.28565100
7negative regulation of homotypic cell-cell adhesion (GO:0034111)6.65893400
8negative regulation of dendrite development (GO:2000171)6.19676037
9establishment of mitochondrion localization (GO:0051654)5.65478077
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.37433294
11mitochondrion transport along microtubule (GO:0047497)5.37433294
12neuronal action potential propagation (GO:0019227)5.31656652
13calcium-mediated signaling using intracellular calcium source (GO:0035584)5.23800551
14* peripheral nervous system neuron development (GO:0048935)4.95392436
15inositol phosphate catabolic process (GO:0071545)4.79908416
16regulation of platelet aggregation (GO:0090330)4.78063699
17neuronal action potential (GO:0019228)4.56829819
18retinal ganglion cell axon guidance (GO:0031290)4.53759411
19mating behavior (GO:0007617)4.53292495
20postsynaptic membrane organization (GO:0001941)4.36291209
21neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.27197284
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.25095233
23regulation of NFAT protein import into nucleus (GO:0051532)4.23512034
24regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.21981076
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.14072726
26serotonin receptor signaling pathway (GO:0007210)4.09103551
27regulation of protein heterodimerization activity (GO:0043497)4.04400128
28membrane depolarization during action potential (GO:0086010)4.03280334
29neuron recognition (GO:0008038)4.02636193
30negative regulation of microtubule polymerization (GO:0031115)4.00496462
31presynaptic membrane organization (GO:0097090)3.93240216
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.90666717
33auditory behavior (GO:0031223)3.86274016
34behavioral response to nicotine (GO:0035095)3.85506287
35dendritic spine morphogenesis (GO:0060997)3.82403042
36presynaptic membrane assembly (GO:0097105)3.79945813
37intermediate filament organization (GO:0045109)3.79116230
38startle response (GO:0001964)3.75536899
39proximal/distal pattern formation (GO:0009954)3.74917678
40negative regulation of cation channel activity (GO:2001258)3.66216348
41detection of mechanical stimulus involved in sensory perception (GO:0050974)3.63044296
42regulation of synapse structural plasticity (GO:0051823)3.61097385
43spinal cord association neuron differentiation (GO:0021527)3.60659883
44hindbrain development (GO:0030902)3.60519022
45response to acidic pH (GO:0010447)3.57483794
46negative regulation of organelle assembly (GO:1902116)3.53034290
47protein localization to microtubule (GO:0035372)3.52221009
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47242963
49lymph vessel development (GO:0001945)3.47083013
50regulation of relaxation of muscle (GO:1901077)3.44293982
51skeletal muscle organ development (GO:0060538)3.43104190
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.41336040
53regulation of respiratory system process (GO:0044065)3.38661394
54nucleobase catabolic process (GO:0046113)3.37903621
55enteric nervous system development (GO:0048484)3.36452674
56positive regulation of mitochondrial fission (GO:0090141)3.32600650
57regulation of cell maturation (GO:1903429)3.32216694
58negative regulation of membrane potential (GO:0045837)3.31839451
59pyrimidine nucleobase catabolic process (GO:0006208)3.30128495
60negative regulation of neurological system process (GO:0031645)3.29980071
61axon development (GO:0061564)3.29807648
62glutamate receptor signaling pathway (GO:0007215)3.29489324
63axonal fasciculation (GO:0007413)3.28772701
64negative regulation of striated muscle cell apoptotic process (GO:0010664)3.28355867
65embryonic retina morphogenesis in camera-type eye (GO:0060059)3.26638482
66dendrite morphogenesis (GO:0048813)3.26455116
67epithelial cell differentiation involved in kidney development (GO:0035850)3.26402691
68acrosome reaction (GO:0007340)3.25664454
69protein polyglutamylation (GO:0018095)3.24339070
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23106037
71neuron cell-cell adhesion (GO:0007158)3.22049186
72negative regulation of platelet activation (GO:0010544)3.21903469
73axon extension (GO:0048675)3.20619458
74positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.19980620
75positive regulation of cell cycle G2/M phase transition (GO:1902751)3.19980620
76potassium ion export (GO:0071435)3.17872014
77positive regulation of CREB transcription factor activity (GO:0032793)3.16866725
78regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15075604
79regulation of sodium ion transmembrane transporter activity (GO:2000649)3.15034377
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.13349861
81regulation of chromatin binding (GO:0035561)3.12904929
82membrane budding (GO:0006900)3.12871208
83response to pain (GO:0048265)3.12451982
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12307926
85* cell migration in hindbrain (GO:0021535)3.11799260
86regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11486638
87organelle transport along microtubule (GO:0072384)3.10146516
88negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.10020644
89synaptic vesicle maturation (GO:0016188)3.09744272
90ventricular trabecula myocardium morphogenesis (GO:0003222)3.09743153
91establishment or maintenance of monopolar cell polarity (GO:0061339)3.09434225
92establishment of monopolar cell polarity (GO:0061162)3.09434225
93regulation of glycogen (starch) synthase activity (GO:2000465)3.09029426
94action potential (GO:0001508)3.07576108
95phosphorylated carbohydrate dephosphorylation (GO:0046838)3.05352732
96inositol phosphate dephosphorylation (GO:0046855)3.05352732
97kidney morphogenesis (GO:0060993)3.04971663
98regulation of cell communication by electrical coupling (GO:0010649)3.03425662
99cranial nerve morphogenesis (GO:0021602)3.02968136
100proline transport (GO:0015824)3.02914778
101regulation of translational termination (GO:0006449)3.02444162
102synaptic vesicle exocytosis (GO:0016079)3.01905756
103myotube differentiation (GO:0014902)2.99703825
104response to auditory stimulus (GO:0010996)2.99227396
105* neuron fate specification (GO:0048665)2.99059898
106regulation of axon regeneration (GO:0048679)2.98295785
107regulation of neuron projection regeneration (GO:0070570)2.98295785
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.98023333
109regulation of homotypic cell-cell adhesion (GO:0034110)2.97772961
110microtubule polymerization or depolymerization (GO:0031109)2.97553222
111regulation of synaptic vesicle exocytosis (GO:2000300)2.97392413
112cytoplasmic mRNA processing body assembly (GO:0033962)2.97024780
113* synapse assembly (GO:0007416)2.96260455
114glutamate secretion (GO:0014047)2.95576754
115positive regulation of axon extension (GO:0045773)2.93023260
116mechanosensory behavior (GO:0007638)2.92845368
117synaptic transmission, glutamatergic (GO:0035249)2.92316471
118cell communication involved in cardiac conduction (GO:0086065)2.92025471
119intermediate filament-based process (GO:0045103)2.90701600
120embryonic body morphogenesis (GO:0010172)2.89314289
121behavioral response to pain (GO:0048266)2.89225966
122spinal cord development (GO:0021510)2.88752694
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.87452235
124intermediate filament cytoskeleton organization (GO:0045104)2.86867644
125urinary tract smooth muscle contraction (GO:0014848)2.86662553
126negative regulation of heart rate (GO:0010459)2.83749044
127protein localization to synapse (GO:0035418)2.82891946
128activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.82423692
129histone H2B ubiquitination (GO:0033523)2.82194443
130cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81986338
131calcium ion-dependent exocytosis (GO:0017156)2.81660327
132protein neddylation (GO:0045116)2.79840374
133ribonucleoprotein complex disassembly (GO:0032988)2.79246723
134sympathetic nervous system development (GO:0048485)2.79150659
135positive regulation by host of viral transcription (GO:0043923)2.79013118
136negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77780508
137stress granule assembly (GO:0034063)2.77768861
138layer formation in cerebral cortex (GO:0021819)2.77409694
139regulation of cardiac muscle cell apoptotic process (GO:0010665)2.77332000
140diaphragm development (GO:0060539)2.77173323
141protein maturation by protein folding (GO:0022417)2.76990315
142body morphogenesis (GO:0010171)2.76791666
143retina layer formation (GO:0010842)2.76506077
144dopaminergic neuron differentiation (GO:0071542)2.76004953
145neuron projection extension (GO:1990138)2.75016546
146regulation of glutamate receptor signaling pathway (GO:1900449)2.74565410
147regulation of membrane repolarization (GO:0060306)2.73875927
148cerebellar Purkinje cell differentiation (GO:0021702)2.73634898
149response to water (GO:0009415)2.73485076
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.73472511
151neurotransmitter-gated ion channel clustering (GO:0072578)2.72512214
152regulation of oxidative stress-induced neuron death (GO:1903203)2.72225340
153glomerulus development (GO:0032835)2.71639039
154vocalization behavior (GO:0071625)2.71442090
155atrial cardiac muscle cell action potential (GO:0086014)2.70862581
156positive regulation of dendritic spine morphogenesis (GO:0061003)2.70128448
157axon cargo transport (GO:0008088)2.69278926
158negative regulation of catenin import into nucleus (GO:0035414)2.68539244
159positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68140864
160histone H2A monoubiquitination (GO:0035518)2.66660785
161positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66032936
162regulation of axon guidance (GO:1902667)2.65499654
163central nervous system projection neuron axonogenesis (GO:0021952)2.65148444
164response to pheromone (GO:0019236)2.63103145
165cell differentiation in spinal cord (GO:0021515)2.62703328
166positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.60577830
167camera-type eye morphogenesis (GO:0048593)2.60251933
168negative regulation of histone methylation (GO:0031061)2.60214241
169regulation of RNA export from nucleus (GO:0046831)2.60070036
170dendrite development (GO:0016358)2.58724455
171nucleosome disassembly (GO:0006337)2.58514924
172protein-DNA complex disassembly (GO:0032986)2.58514924
173* suckling behavior (GO:0001967)2.55275328
174neuron remodeling (GO:0016322)2.55057156
175neuron migration (GO:0001764)2.52404989
176cerebellum development (GO:0021549)2.50532205
177regulation of microtubule-based movement (GO:0060632)2.45659777
178RNA localization (GO:0006403)2.45237255
179positive regulation of mesonephros development (GO:0061213)2.44629853
180histone monoubiquitination (GO:0010390)2.41042726
181lateral sprouting from an epithelium (GO:0060601)2.40687777
182nonmotile primary cilium assembly (GO:0035058)2.40376049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.50196533
2EZH2_22144423_ChIP-Seq_EOC_Human3.57769697
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.57153611
4TAF15_26573619_Chip-Seq_HEK293_Human3.55397521
5GBX2_23144817_ChIP-Seq_PC3_Human3.27528488
6* BMI1_23680149_ChIP-Seq_NPCS_Mouse3.13000982
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78965787
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70138564
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67680768
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.66830191
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66701869
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63406425
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61566470
14IGF1R_20145208_ChIP-Seq_DFB_Human2.61073360
15* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60030048
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52573520
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52573520
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37782424
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.30954396
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.30663537
21NR3C1_23031785_ChIP-Seq_PC12_Mouse2.21206589
22* RNF2_27304074_Chip-Seq_NSC_Mouse2.11101928
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10692426
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09778121
25* RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.06379444
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00865083
27P300_19829295_ChIP-Seq_ESCs_Human1.99752644
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99419771
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98756157
30* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97189057
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92701368
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.90721369
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.86264113
34* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84777121
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84622946
36SMAD4_21799915_ChIP-Seq_A2780_Human1.84089207
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.81870903
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81348030
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77433425
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74293344
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74198100
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.72184170
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66579083
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66360040
45EWS_26573619_Chip-Seq_HEK293_Human1.63481957
46* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61485485
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61406774
48AHR_22903824_ChIP-Seq_MCF-7_Human1.56556830
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52701344
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52701344
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52192552
52VDR_22108803_ChIP-Seq_LS180_Human1.50525994
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50108297
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49631745
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48452479
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.46370497
57AR_21572438_ChIP-Seq_LNCaP_Human1.42817503
58CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40554942
59AR_25329375_ChIP-Seq_VCAP_Human1.40165993
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39873462
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38095648
62JUN_21703547_ChIP-Seq_K562_Human1.35910546
63DROSHA_22980978_ChIP-Seq_HELA_Human1.35418515
64STAT3_23295773_ChIP-Seq_U87_Human1.34335403
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.33923385
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33579932
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.32129188
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.31963909
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31533769
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31350216
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30967356
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30811536
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30431920
74BCAT_22108803_ChIP-Seq_LS180_Human1.29684376
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28142984
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.26562484
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.25874649
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25745841
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25562093
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25367206
81* KDM2B_26808549_Chip-Seq_REH_Human1.24929773
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24864496
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23467717
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22586644
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20112100
86ZNF263_19887448_ChIP-Seq_K562_Human1.19752258
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19254439
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18671013
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.16728939
90SOX2_19829295_ChIP-Seq_ESCs_Human1.16056924
91NANOG_19829295_ChIP-Seq_ESCs_Human1.16056924
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.15716002
93FUS_26573619_Chip-Seq_HEK293_Human1.15040885
94* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14331998
95* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11601432
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.10466011
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.10315867
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09917902
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.09365277
100ZNF274_21170338_ChIP-Seq_K562_Hela1.08867819
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08399276
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07400519
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06176227
104CTCF_27219007_Chip-Seq_Bcells_Human1.05403119
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03698625
106CIITA_25753668_ChIP-Seq_RAJI_Human1.02167461
107* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01450808
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01421543
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01217349
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00666150
111* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99422591
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98308366
113YY1_21170310_ChIP-Seq_MESCs_Mouse0.97749624
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.97601006
115* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97548634
116* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97547303
117KDM2B_26808549_Chip-Seq_K562_Human0.96814032
118SALL1_21062744_ChIP-ChIP_HESCs_Human0.96002281
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95703145
120XRN2_22483619_ChIP-Seq_HELA_Human0.95272140
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.94717796
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.93997479
123* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92745447
124* RARB_27405468_Chip-Seq_BRAIN_Mouse0.92648929
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91517238
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.90618337
127TCF4_22108803_ChIP-Seq_LS180_Human0.90354383
128* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90325058
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89963810
130AR_19668381_ChIP-Seq_PC3_Human0.89694990
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.89456795
132* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89454699
133* TP53_20018659_ChIP-ChIP_R1E_Mouse0.88966796
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88931516
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88407271
136MYC_22102868_ChIP-Seq_BL_Human0.88220350
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87934447
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86307066
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85367431
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83572393
141SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.82972137
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82127962
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79298975
144KDM2B_26808549_Chip-Seq_DND41_Human0.79268788
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77341243
146* KDM2B_26808549_Chip-Seq_JURKAT_Human0.77186986
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76186047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.43982041
2MP0004270_analgesia5.61566475
3MP0001986_abnormal_taste_sensitivity5.41619577
4MP0006276_abnormal_autonomic_nervous5.02075629
5MP0001968_abnormal_touch/_nociception4.31628970
6MP0004858_abnormal_nervous_system4.03658285
7MP0002736_abnormal_nociception_after3.84788612
8MP0002734_abnormal_mechanical_nocicepti3.81484318
9MP0002733_abnormal_thermal_nociception3.29580279
10MP0003880_abnormal_central_pattern3.23655628
11MP0001970_abnormal_pain_threshold2.89574891
12MP0003122_maternal_imprinting2.80705948
13MP0002751_abnormal_autonomic_nervous2.72463969
14MP0009379_abnormal_foot_pigmentation2.65672050
15MP0002184_abnormal_innervation2.60454289
16MP0004147_increased_porphyrin_level2.31018592
17MP0002822_catalepsy2.16109532
18MP0001348_abnormal_lacrimal_gland2.15547090
19MP0003121_genomic_imprinting2.10013391
20MP0004885_abnormal_endolymph2.07154245
21MP0002272_abnormal_nervous_system2.06652612
22MP0005645_abnormal_hypothalamus_physiol2.03480411
23MP0003283_abnormal_digestive_organ1.99762874
24MP0004859_abnormal_synaptic_plasticity1.93776576
25MP0009046_muscle_twitch1.88168511
26MP0006292_abnormal_olfactory_placode1.84143155
27* MP0002067_abnormal_sensory_capabilities1.82883916
28MP0001346_abnormal_lacrimal_gland1.80796405
29MP0000569_abnormal_digit_pigmentation1.80533159
30MP0003890_abnormal_embryonic-extraembry1.77693613
31MP0000955_abnormal_spinal_cord1.77331792
32MP0001188_hyperpigmentation1.74377429
33MP0003635_abnormal_synaptic_transmissio1.72971190
34MP0002877_abnormal_melanocyte_morpholog1.68810798
35MP0002234_abnormal_pharynx_morphology1.63774482
36MP0005187_abnormal_penis_morphology1.63493392
37MP0000778_abnormal_nervous_system1.61668908
38MP0004811_abnormal_neuron_physiology1.59836241
39MP0000372_irregular_coat_pigmentation1.55824561
40MP0000566_synostosis1.49600719
41MP0001984_abnormal_olfaction1.48713507
42MP0002063_abnormal_learning/memory/cond1.46747706
43MP0003942_abnormal_urinary_system1.46015251
44MP0008995_early_reproductive_senescence1.45282083
45MP0000049_abnormal_middle_ear1.45158602
46MP0004142_abnormal_muscle_tone1.39019094
47MP0005367_renal/urinary_system_phenotyp1.33731764
48MP0000516_abnormal_urinary_system1.33731764
49* MP0002882_abnormal_neuron_morphology1.32610132
50MP0002572_abnormal_emotion/affect_behav1.31768433
51MP0005623_abnormal_meninges_morphology1.27831054
52MP0003329_amyloid_beta_deposits1.25577277
53MP0009745_abnormal_behavioral_response1.24756647
54MP0002064_seizures1.23194691
55MP0004133_heterotaxia1.22861275
56MP0005423_abnormal_somatic_nervous1.21319150
57MP0003935_abnormal_craniofacial_develop1.20453594
58* MP0002752_abnormal_somatic_nervous1.19764160
59MP0001486_abnormal_startle_reflex1.16374432
60MP0005083_abnormal_biliary_tract1.16076308
61MP0003119_abnormal_digestive_system1.15207675
62MP0003937_abnormal_limbs/digits/tail_de1.15099914
63MP0003385_abnormal_body_wall1.12881115
64MP0000631_abnormal_neuroendocrine_gland1.12579792
65MP0002229_neurodegeneration1.12153410
66MP0002932_abnormal_joint_morphology1.11526008
67MP0001286_abnormal_eye_development1.10405923
68MP0002909_abnormal_adrenal_gland1.08696681
69MP0001485_abnormal_pinna_reflex1.08565640
70MP0002938_white_spotting1.08496052
71MP0002697_abnormal_eye_size1.08155728
72MP0008569_lethality_at_weaning1.07451377
73MP0000678_abnormal_parathyroid_gland1.03820663
74MP0002249_abnormal_larynx_morphology1.03725207
75* MP0002081_perinatal_lethality1.03710812
76MP0000537_abnormal_urethra_morphology1.03040975
77MP0001919_abnormal_reproductive_system1.03031478
78MP0001440_abnormal_grooming_behavior1.00964420
79MP0003879_abnormal_hair_cell1.00936083
80MP0000751_myopathy0.98084732
81MP0008260_abnormal_autophagy0.96808193
82MP0002138_abnormal_hepatobiliary_system0.96661166
83MP0000015_abnormal_ear_pigmentation0.96018444
84MP0004924_abnormal_behavior0.95914550
85MP0005386_behavior/neurological_phenoty0.95914550
86MP0003123_paternal_imprinting0.95240387
87MP0001963_abnormal_hearing_physiology0.94067099
88MP0000749_muscle_degeneration0.93493887
89MP0002160_abnormal_reproductive_system0.93092598
90MP0002557_abnormal_social/conspecific_i0.93077081
91MP0002116_abnormal_craniofacial_bone0.91952721
92MP0001905_abnormal_dopamine_level0.91231529
93MP0003656_abnormal_erythrocyte_physiolo0.91185775
94MP0004742_abnormal_vestibular_system0.90464771
95* MP0002066_abnormal_motor_capabilities/c0.90138901
96MP0003646_muscle_fatigue0.90117223
97MP0002114_abnormal_axial_skeleton0.89425413
98MP0002102_abnormal_ear_morphology0.88307631
99MP0003315_abnormal_perineum_morphology0.88220428
100MP0005220_abnormal_exocrine_pancreas0.88043821
101MP0001293_anophthalmia0.85728251
102MP0001299_abnormal_eye_distance/0.85471810
103MP0004085_abnormal_heartbeat0.85176875
104MP0001529_abnormal_vocalization0.84133225
105MP0002084_abnormal_developmental_patter0.83939156
106MP0000534_abnormal_ureter_morphology0.81535866
107MP0009053_abnormal_anal_canal0.79692053
108MP0003183_abnormal_peptide_metabolism0.79396708
109MP0003567_abnormal_fetal_cardiomyocyte0.79395943
110MP0004145_abnormal_muscle_electrophysio0.78058546
111MP0003755_abnormal_palate_morphology0.77899000
112MP0000538_abnormal_urinary_bladder0.77204368
113MP0003634_abnormal_glial_cell0.76196144
114MP0001270_distended_abdomen0.73840317
115MP0002876_abnormal_thyroid_physiology0.73619746
116MP0008789_abnormal_olfactory_epithelium0.72894651
117MP0002653_abnormal_ependyma_morphology0.71817197
118MP0002009_preneoplasia0.67906397
119MP0005389_reproductive_system_phenotype0.66632089
120MP0000026_abnormal_inner_ear0.66526282
121MP0004883_abnormal_blood_vessel0.65221779
122MP0002163_abnormal_gland_morphology0.61387068
123MP0001502_abnormal_circadian_rhythm0.61031462
124MP0001542_abnormal_bone_strength0.60396379
125MP0008775_abnormal_heart_ventricle0.58294000
126MP0003861_abnormal_nervous_system0.57632010
127MP0005535_abnormal_body_temperature0.57093642
128MP0009697_abnormal_copulation0.55897725
129MP0001849_ear_inflammation0.54404226
130* MP0002152_abnormal_brain_morphology0.54204358
131MP0005409_darkened_coat_color0.53984799
132MP0005499_abnormal_olfactory_system0.53042506
133MP0005394_taste/olfaction_phenotype0.53042506
134MP0001943_abnormal_respiration0.52541883
135MP0000604_amyloidosis0.51389831
136MP0008932_abnormal_embryonic_tissue0.49101120
137MP0002837_dystrophic_cardiac_calcinosis0.48171756
138MP0008874_decreased_physiological_sensi0.47247459
139MP0000427_abnormal_hair_cycle0.46911330
140MP0005408_hypopigmentation0.44962190
141MP0009250_abnormal_appendicular_skeleto0.44839409
142MP0002972_abnormal_cardiac_muscle0.42666126
143MP0003631_nervous_system_phenotype0.42607145
144MP0003938_abnormal_ear_development0.41556627
145MP0006035_abnormal_mitochondrial_morpho0.40621544
146MP0002928_abnormal_bile_duct0.39388953

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.51737195
2Ulnar claw (HP:0001178)7.46167444
3Hypothermia (HP:0002045)5.94528365
4Action tremor (HP:0002345)5.82748618
5Birth length less than 3rd percentile (HP:0003561)5.53810566
6Febrile seizures (HP:0002373)5.44551758
7Termporal pattern (HP:0011008)4.78099289
8Insidious onset (HP:0003587)4.78099289
9Pheochromocytoma (HP:0002666)4.68915271
10Neuroendocrine neoplasm (HP:0100634)4.46923895
11Atonic seizures (HP:0010819)4.38939429
12Focal motor seizures (HP:0011153)3.80768398
13Impaired pain sensation (HP:0007328)3.77969926
14Abnormality of pain sensation (HP:0010832)3.77969926
15High anterior hairline (HP:0009890)3.52302933
16Progressive cerebellar ataxia (HP:0002073)3.51726981
17Breast hypoplasia (HP:0003187)3.42957603
18Failure to thrive in infancy (HP:0001531)3.42876677
19Segmental peripheral demyelination/remyelination (HP:0003481)3.41267373
20Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.38592191
21Morphological abnormality of the middle ear (HP:0008609)3.35810035
22Steppage gait (HP:0003376)3.35610371
23Dysautonomia (HP:0002459)3.35123628
24Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.29369004
25Foot dorsiflexor weakness (HP:0009027)3.24032676
26Thyroid carcinoma (HP:0002890)3.23147757
27Calcaneovalgus deformity (HP:0001848)3.20494956
28Focal seizures (HP:0007359)3.13613800
29Autoamputation (HP:0001218)3.12820412
30Bradycardia (HP:0001662)3.12467680
31Submucous cleft hard palate (HP:0000176)3.02376567
32Patellar aplasia (HP:0006443)3.01912667
33Renovascular hypertension (HP:0100817)2.95766052
34Distal arthrogryposis (HP:0005684)2.92921286
35Myotonia (HP:0002486)2.91700120
36Abnormality of the foot musculature (HP:0001436)2.89368912
37Fetal akinesia sequence (HP:0001989)2.87734150
38Abnormal hair whorl (HP:0010721)2.87049505
39Thoracolumbar scoliosis (HP:0002944)2.86851977
40Abnormality of the corticospinal tract (HP:0002492)2.83794145
41Shawl scrotum (HP:0000049)2.81504683
42Elfin facies (HP:0004428)2.80560979
43Tongue fasciculations (HP:0001308)2.79433898
44Muscle fibrillation (HP:0010546)2.77377328
45Hyperacusis (HP:0010780)2.76394857
46Aplasia/Hypoplasia of the patella (HP:0006498)2.74465891
47Amblyopia (HP:0000646)2.74244113
48Hammertoe (HP:0001765)2.73991765
49Decreased motor nerve conduction velocity (HP:0003431)2.73062304
50Neoplasm of the peripheral nervous system (HP:0100007)2.69677097
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.68779451
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.64423706
53Deformed tarsal bones (HP:0008119)2.63808241
54Diastasis recti (HP:0001540)2.62553318
55Hypoplasia of the brainstem (HP:0002365)2.61707420
56Aplasia/Hypoplasia of the brainstem (HP:0007362)2.61707420
57Absence seizures (HP:0002121)2.60511261
58Exotropia (HP:0000577)2.58056348
59Distal sensory impairment (HP:0002936)2.56189539
60Acute lymphatic leukemia (HP:0006721)2.55410938
61Abnormality of the vocal cords (HP:0008777)2.52479811
62Spastic gait (HP:0002064)2.52222603
63Ankle clonus (HP:0011448)2.49808090
64Obsessive-compulsive behavior (HP:0000722)2.49723299
65Curly hair (HP:0002212)2.48120986
66Hypercortisolism (HP:0001578)2.47912981
67Urinary urgency (HP:0000012)2.47746434
68Areflexia of lower limbs (HP:0002522)2.46027765
69Abnormal number of incisors (HP:0011064)2.45045603
70Supranuclear gaze palsy (HP:0000605)2.44359953
71Delusions (HP:0000746)2.41434778
72Akinesia (HP:0002304)2.40733557
73Microretrognathia (HP:0000308)2.37214473
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.37006995
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37006995
76Volvulus (HP:0002580)2.36282210
77Urinary bladder sphincter dysfunction (HP:0002839)2.35285738
78Partial agenesis of the corpus callosum (HP:0001338)2.34631548
79Overriding aorta (HP:0002623)2.34071782
80Abnormality of the 4th metacarpal (HP:0010012)2.33971064
81Sacral dimple (HP:0000960)2.33727777
82Genu recurvatum (HP:0002816)2.32026698
83Aqueductal stenosis (HP:0002410)2.31473150
84Chin dimple (HP:0010751)2.31039244
85Dialeptic seizures (HP:0011146)2.29406833
86Genetic anticipation (HP:0003743)2.29231562
87Nonimmune hydrops fetalis (HP:0001790)2.28653262
88Double outlet right ventricle (HP:0001719)2.28418780
89Congenital malformation of the right heart (HP:0011723)2.28418780
90Cutaneous finger syndactyly (HP:0010554)2.28190065
91Abnormality of the aortic arch (HP:0012303)2.25594205
92Generalized hypotonia (HP:0001290)2.25559549
93Decreased muscle mass (HP:0003199)2.25497524
94Menstrual irregularities (HP:0000858)2.19914484
95Abnormality of the calcaneus (HP:0008364)2.19847871
96Popliteal pterygium (HP:0009756)2.19221462
97Abnormality of the lower motor neuron (HP:0002366)2.18870326
98Poor suck (HP:0002033)2.18267405
99Slender long bone (HP:0003100)2.18204874
100Anterior segment dysgenesis (HP:0007700)2.16718150
101Insomnia (HP:0100785)2.16240695
102Pachygyria (HP:0001302)2.15418459
103Delayed gross motor development (HP:0002194)2.13838691
104Truncus arteriosus (HP:0001660)2.13724322
105Megalocornea (HP:0000485)2.13539964
106Broad-based gait (HP:0002136)2.11612229
107Renal duplication (HP:0000075)2.10337581
108Flat cornea (HP:0007720)2.09695586
109Abnormality of chromosome segregation (HP:0002916)2.08606435
110Abnormality of magnesium homeostasis (HP:0004921)2.08062062
111Generalized tonic-clonic seizures (HP:0002069)2.07647900
112Fasciculations (HP:0002380)2.06666863
113Abnormality of the phalanges of the hallux (HP:0010057)2.04983814
114Stridor (HP:0010307)2.04946453
115Neoplasm of the adrenal cortex (HP:0100641)2.04281645
116Paraplegia (HP:0010550)2.03325463
117Mild short stature (HP:0003502)2.01873778
118Cutaneous syndactyly (HP:0012725)2.01339442
119Epileptic encephalopathy (HP:0200134)2.00545758
120Truncal ataxia (HP:0002078)2.00001059
121Abnormal autonomic nervous system physiology (HP:0012332)1.99828461
122Drooling (HP:0002307)1.98712389
123Limb dystonia (HP:0002451)1.98426972
124Ventricular fibrillation (HP:0001663)1.98422211
125Abnormality of the left ventricular outflow tract (HP:0011103)1.98370259
126Subaortic stenosis (HP:0001682)1.98370259
127Onion bulb formation (HP:0003383)1.98363918
128Cerebral hemorrhage (HP:0001342)1.97322589
129Acute necrotizing encephalopathy (HP:0006965)1.96731900
130Apathy (HP:0000741)1.93711477
131Abnormal ventriculo-arterial connection (HP:0011563)1.93597451
132Transposition of the great arteries (HP:0001669)1.93597451
133Abnormal connection of the cardiac segments (HP:0011545)1.93597451
134Hypoventilation (HP:0002791)1.93466157
135Radioulnar synostosis (HP:0002974)1.92860596
136Progressive macrocephaly (HP:0004481)1.92594093
137Agitation (HP:0000713)1.89103505
138Retinal dysplasia (HP:0007973)1.88711360
139Lissencephaly (HP:0001339)1.87227577
140Vesicoureteral reflux (HP:0000076)1.84575655
141Lower limb muscle weakness (HP:0007340)1.84462731
142Increased nuchal translucency (HP:0010880)1.83839804
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.80967957
144Deep palmar crease (HP:0006191)1.80720670
145Oligomenorrhea (HP:0000876)1.80621205
146Asymmetry of the thorax (HP:0001555)1.79132903
147Overlapping toe (HP:0001845)1.78908817
148Hypoplasia of the maxilla (HP:0000327)1.78906497
149Pendular nystagmus (HP:0012043)1.78442998
150Esotropia (HP:0000565)1.77424230
151Gaze-evoked nystagmus (HP:0000640)1.77014958
152Excessive salivation (HP:0003781)1.76396316
153Scanning speech (HP:0002168)1.75621169
154Impaired vibration sensation in the lower limbs (HP:0002166)1.74743260
155Diminished motivation (HP:0000745)1.73968883
156Testicular neoplasm (HP:0010788)1.73494891
157Long clavicles (HP:0000890)1.72852736
158Posterior embryotoxon (HP:0000627)1.72452466
159Patellar dislocation (HP:0002999)1.72398126
160Abnormality of midbrain morphology (HP:0002418)1.71300317
161Molar tooth sign on MRI (HP:0002419)1.71300317
162Septate vagina (HP:0001153)1.70987143
163Distal lower limb muscle weakness (HP:0009053)1.70926075
164Protruding tongue (HP:0010808)1.70861599
165Scrotal hypoplasia (HP:0000046)1.70415076
166Wide anterior fontanel (HP:0000260)1.69379255
167Lower limb asymmetry (HP:0100559)1.69253014
168Neonatal short-limb short stature (HP:0008921)1.69065744
169Hyperthyroidism (HP:0000836)1.68686600
170Arthropathy (HP:0003040)1.68667425
171Abnormal mitochondria in muscle tissue (HP:0008316)1.68472943
172Congenital diaphragmatic hernia (HP:0000776)1.68283537
173Absent phalangeal crease (HP:0006109)1.67875845
174Abnormality of the intervertebral disk (HP:0005108)1.67851696
175Concave nail (HP:0001598)1.67179504
176Visual hallucinations (HP:0002367)1.67003830
177Abnormality of the line of Schwalbe (HP:0008048)1.66623564
178Atresia of the external auditory canal (HP:0000413)1.66532558
179Abnormality of the incisor (HP:0000676)1.65726144
180Highly arched eyebrow (HP:0002553)1.65313737
181Pointed chin (HP:0000307)1.64176081
182Peritonitis (HP:0002586)1.63602718
183Midline defect of the nose (HP:0004122)1.63334118
184Abnormality of the fingertips (HP:0001211)1.61742769
185Spastic tetraparesis (HP:0001285)1.61605390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.72740157
2TNIK4.00699251
3MINK13.82451745
4NTRK33.45138990
5SIK33.38166590
6EEF2K2.94122782
7MAPK132.80592362
8NTRK12.76303351
9CDK122.70478226
10MAPKAPK32.61635746
11MAP3K122.52903591
12SIK22.49787384
13SGK22.38501485
14LIMK12.19751678
15LMTK22.15652505
16BRD42.12920228
17LATS22.07500044
18SGK4942.00657557
19SGK2232.00657557
20GRK51.99934019
21KSR21.92044475
22MOS1.88468062
23ICK1.86739381
24ARAF1.86226516
25TGFBR11.76648031
26BCR1.76348849
27MATK1.75555686
28MKNK21.72222820
29DYRK21.72222404
30MAP2K71.70330513
31CAMK1G1.70007637
32MARK11.61616732
33STK161.61435147
34NEK21.57835773
35MAP3K91.56457799
36AKT31.55720466
37NEK91.54432683
38TYRO31.53431262
39MAP3K101.45285905
40CAMKK11.44086336
41SGK31.37710539
42BMPR1B1.37628126
43YES11.37305118
44RPS6KA21.34634825
45RPS6KA41.32073764
46EPHA31.31459989
47KSR11.31375325
48MAP3K41.30990014
49MAP2K41.28781459
50MAPKAPK51.26691267
51MAP2K11.24443628
52PHKG11.24218722
53PHKG21.24218722
54PRPF4B1.23474894
55MKNK11.22648163
56STK38L1.14962847
57PLK21.12951129
58RET1.10937474
59TRIB31.05831007
60MAP3K21.05146892
61BRAF1.04637466
62SCYL21.02155451
63UHMK11.02109032
64MUSK0.99338513
65CDC70.97668125
66ADRBK10.91016961
67PAK60.90657090
68WNK10.90647718
69STK390.90142363
70CHEK20.88944964
71CDK90.88831647
72STK240.86390745
73CDK80.80953789
74PRKCG0.80023150
75AURKA0.77868520
76CDK70.77541340
77STK110.76444775
78CDK11A0.75806991
79FGFR30.72960539
80ERBB30.72907307
81CAMK1D0.71831958
82FER0.70651462
83ALK0.69634462
84WNK40.69599608
85CDK50.68332030
86PKN10.66479214
87FES0.66368913
88ERBB40.65533048
89CSNK1G30.64941757
90CAMKK20.63760030
91RPS6KB10.63132514
92TNK20.62183857
93PRKCH0.61181912
94CSNK1G20.60783480
95CDK140.60294601
96NTRK20.58876551
97CAMK40.57622173
98PINK10.56670383
99EPHB20.56360667
100VRK10.56248712
101NME10.54940684
102ZAK0.54478034
103PIM20.53811207
104ATR0.53725162
105MAP2K60.53247342
106GRK70.50268760
107CDK180.49611485
108MAP3K110.48801002
109DAPK20.48115971
110TAF10.47738661
111PLK40.47519890
112CDK20.47484498
113CLK10.47458093
114PRKCE0.47456568
115MTOR0.46491413
116RPS6KC10.46213329
117RPS6KL10.46213329
118CDK10.45955421
119MAP3K70.45301701
120CAMK2A0.43226069
121ADRBK20.42237083
122DYRK30.40233574
123GSK3B0.40022129
124MAP3K10.40012694
125FRK0.39841865
126TLK10.39716911
127DDR20.38869329
128RIPK40.38595667
129PRKG20.37978193
130MAP3K130.37471233
131ATM0.37101770
132CHEK10.37081738
133CDK30.37074677
134PRKACA0.36842365
135ROCK20.35916041
136PRKAA10.34983866
137ROCK10.34954478
138CSNK1A1L0.34740747
139MAPK80.34476710
140DYRK1A0.34366320
141PKN20.33955189
142CAMK2G0.32148628
143MARK30.30792889
144CSNK1G10.30655169
145CSNK1E0.29943736
146PNCK0.29494374
147RPS6KA60.29107206
148PRKACG0.26566718
149CDK150.26375779
150PLK30.25568951
151PRKACB0.25518611
152MAPK100.24686052
153PRKCZ0.21618668
154RPS6KB20.21573642

Predicted pathways (KEGG)

RankGene SetZ-score
1Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.96007408
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58009638
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.09866052
4Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.83854030
5Olfactory transduction_Homo sapiens_hsa047402.54621620
6Taste transduction_Homo sapiens_hsa047422.51918609
7Cocaine addiction_Homo sapiens_hsa050302.40139754
8Oxidative phosphorylation_Homo sapiens_hsa001902.19751547
9Parkinsons disease_Homo sapiens_hsa050122.09247174
10Thyroid cancer_Homo sapiens_hsa052161.92818006
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91553741
12Dopaminergic synapse_Homo sapiens_hsa047281.88816530
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.78797327
14Insulin secretion_Homo sapiens_hsa049111.77979708
15mRNA surveillance pathway_Homo sapiens_hsa030151.77865517
16Basal cell carcinoma_Homo sapiens_hsa052171.70637666
17Alzheimers disease_Homo sapiens_hsa050101.67130860
18Serotonergic synapse_Homo sapiens_hsa047261.64388612
19Huntingtons disease_Homo sapiens_hsa050161.63924524
20Cardiac muscle contraction_Homo sapiens_hsa042601.60079157
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59783810
22Cholinergic synapse_Homo sapiens_hsa047251.58172807
23Proteasome_Homo sapiens_hsa030501.56707490
24Renal cell carcinoma_Homo sapiens_hsa052111.54068064
25Type II diabetes mellitus_Homo sapiens_hsa049301.53905267
26Long-term potentiation_Homo sapiens_hsa047201.53665642
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.53549536
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51681201
29Cell cycle_Homo sapiens_hsa041101.50618599
30Collecting duct acid secretion_Homo sapiens_hsa049661.49583797
31Endometrial cancer_Homo sapiens_hsa052131.49293200
32Oocyte meiosis_Homo sapiens_hsa041141.47345388
33Basal transcription factors_Homo sapiens_hsa030221.41897547
34Asthma_Homo sapiens_hsa053101.41348471
35ErbB signaling pathway_Homo sapiens_hsa040121.39417653
36Dorso-ventral axis formation_Homo sapiens_hsa043201.38954946
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36970676
38RNA degradation_Homo sapiens_hsa030181.35755856
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33534542
40Melanoma_Homo sapiens_hsa052181.31185647
41Circadian entrainment_Homo sapiens_hsa047131.28047522
42Spliceosome_Homo sapiens_hsa030401.26688013
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26290954
44RNA transport_Homo sapiens_hsa030131.25801147
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25437703
46GnRH signaling pathway_Homo sapiens_hsa049121.24433163
47Phototransduction_Homo sapiens_hsa047441.22676718
48Axon guidance_Homo sapiens_hsa043601.22337027
49Lysine degradation_Homo sapiens_hsa003101.21444044
50Glutamatergic synapse_Homo sapiens_hsa047241.21086034
51Notch signaling pathway_Homo sapiens_hsa043301.20389652
52Hippo signaling pathway_Homo sapiens_hsa043901.18370630
53Sulfur relay system_Homo sapiens_hsa041221.18022010
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17349617
55Regulation of autophagy_Homo sapiens_hsa041401.16487225
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16310526
57Nicotine addiction_Homo sapiens_hsa050331.15618189
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14272788
59Prolactin signaling pathway_Homo sapiens_hsa049171.14141366
60Gap junction_Homo sapiens_hsa045401.09086734
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08277935
62Salmonella infection_Homo sapiens_hsa051321.03646603
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03210285
64Phagosome_Homo sapiens_hsa041451.02450806
65Insulin signaling pathway_Homo sapiens_hsa049101.00719300
66Glioma_Homo sapiens_hsa052140.99858305
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98359262
68Vibrio cholerae infection_Homo sapiens_hsa051100.97941548
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97911727
70Alcoholism_Homo sapiens_hsa050340.96135842
71Melanogenesis_Homo sapiens_hsa049160.95993680
72Steroid biosynthesis_Homo sapiens_hsa001000.95234267
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.93107263
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92705921
75mTOR signaling pathway_Homo sapiens_hsa041500.90916732
76Salivary secretion_Homo sapiens_hsa049700.90887543
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88463085
78Chronic myeloid leukemia_Homo sapiens_hsa052200.87702135
79GABAergic synapse_Homo sapiens_hsa047270.83184779
80MicroRNAs in cancer_Homo sapiens_hsa052060.80324416
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79253497
82Amphetamine addiction_Homo sapiens_hsa050310.78370311
83Bladder cancer_Homo sapiens_hsa052190.78178960
84Base excision repair_Homo sapiens_hsa034100.77470977
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76971172
86Gastric acid secretion_Homo sapiens_hsa049710.76701091
87Endocytosis_Homo sapiens_hsa041440.74767178
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73328563
89Ribosome_Homo sapiens_hsa030100.72739795
90Oxytocin signaling pathway_Homo sapiens_hsa049210.72011007
91Morphine addiction_Homo sapiens_hsa050320.70042845
92Renin secretion_Homo sapiens_hsa049240.69274805
93Ras signaling pathway_Homo sapiens_hsa040140.69195574
94Calcium signaling pathway_Homo sapiens_hsa040200.68715994
95VEGF signaling pathway_Homo sapiens_hsa043700.68581383
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68171706
97Long-term depression_Homo sapiens_hsa047300.68164338
98Colorectal cancer_Homo sapiens_hsa052100.67892437
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67000049
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65670498
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65063610
102MAPK signaling pathway_Homo sapiens_hsa040100.63913838
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.63891193
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.62909104
105Choline metabolism in cancer_Homo sapiens_hsa052310.61486570
106FoxO signaling pathway_Homo sapiens_hsa040680.58763155
107Fatty acid elongation_Homo sapiens_hsa000620.57967336
108cAMP signaling pathway_Homo sapiens_hsa040240.57834793
109Pancreatic cancer_Homo sapiens_hsa052120.55481380
110Nitrogen metabolism_Homo sapiens_hsa009100.54121966
111DNA replication_Homo sapiens_hsa030300.53694659
112Rap1 signaling pathway_Homo sapiens_hsa040150.53671461
113Estrogen signaling pathway_Homo sapiens_hsa049150.53375840
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53189186
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52659288
116Viral myocarditis_Homo sapiens_hsa054160.51597403
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49806612
118Pyruvate metabolism_Homo sapiens_hsa006200.49355132
119Hedgehog signaling pathway_Homo sapiens_hsa043400.48335069
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.47837122
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.46971859
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46964849
123Glucagon signaling pathway_Homo sapiens_hsa049220.46826689
124Epstein-Barr virus infection_Homo sapiens_hsa051690.44694336
125Inositol phosphate metabolism_Homo sapiens_hsa005620.44250685
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.43407735
127Pathways in cancer_Homo sapiens_hsa052000.42678844
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41737744
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41570299
130Adherens junction_Homo sapiens_hsa045200.40505001
131Non-small cell lung cancer_Homo sapiens_hsa052230.40470556
132B cell receptor signaling pathway_Homo sapiens_hsa046620.40078349
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39135223
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36969975
135Prion diseases_Homo sapiens_hsa050200.36892439
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35685407
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35267563
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34002924
139Wnt signaling pathway_Homo sapiens_hsa043100.33886220
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.32746486
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31859246

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