POTEI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)6.99730791
2adaptation of signaling pathway (GO:0023058)6.13308565
3negative regulation of sodium ion transport (GO:0010766)5.44809108
4retinal metabolic process (GO:0042574)5.35140699
5import into cell (GO:0098657)5.22872928
6negative regulation of protein localization to cell surface (GO:2000009)4.75842560
7branching involved in prostate gland morphogenesis (GO:0060442)4.65592008
8negative regulation of systemic arterial blood pressure (GO:0003085)4.55921386
9positive regulation of glycolytic process (GO:0045821)4.46917038
10prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.41319167
11detection of temperature stimulus (GO:0016048)4.31178234
12indole-containing compound catabolic process (GO:0042436)4.11282960
13indolalkylamine catabolic process (GO:0046218)4.11282960
14tryptophan catabolic process (GO:0006569)4.11282960
15interkinetic nuclear migration (GO:0022027)4.07124751
16lung lobe morphogenesis (GO:0060463)4.06072857
17regulation of hippo signaling (GO:0035330)4.04113783
18phospholipid scrambling (GO:0017121)3.98584004
19establishment of protein localization to Golgi (GO:0072600)3.97353942
20biotin metabolic process (GO:0006768)3.96881228
21monoubiquitinated protein deubiquitination (GO:0035520)3.96780038
22protein homotrimerization (GO:0070207)3.93344236
23lung vasculature development (GO:0060426)3.86449904
24indolalkylamine metabolic process (GO:0006586)3.79066429
25artery development (GO:0060840)3.77402795
26regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.77329378
27tryptophan metabolic process (GO:0006568)3.64794674
28kynurenine metabolic process (GO:0070189)3.61408955
29regulation of establishment or maintenance of cell polarity (GO:0032878)3.60738829
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60498356
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.60498356
32regulation of translation, ncRNA-mediated (GO:0045974)3.60498356
33benzene-containing compound metabolic process (GO:0042537)3.53886051
34positive regulation of steroid hormone secretion (GO:2000833)3.53427275
35diterpenoid biosynthetic process (GO:0016102)3.52554174
36UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45573143
37endothelial cell chemotaxis (GO:0035767)3.37985614
38cilium or flagellum-dependent cell motility (GO:0001539)3.32379743
39positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.19930078
40regulation of posttranscriptional gene silencing (GO:0060147)3.18777983
41regulation of gene silencing by miRNA (GO:0060964)3.18777983
42regulation of gene silencing by RNA (GO:0060966)3.18777983
43reflex (GO:0060004)3.11217209
44response to cold (GO:0009409)3.08933559
45detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.08407639
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.05580301
47cellular biogenic amine catabolic process (GO:0042402)3.04967952
48amine catabolic process (GO:0009310)3.04967952
49tachykinin receptor signaling pathway (GO:0007217)3.04553125
50positive regulation of glycogen biosynthetic process (GO:0045725)3.02647772
51regulation of establishment of cell polarity (GO:2000114)3.01576913
52prostate gland growth (GO:0060736)2.96169100
53protein targeting to Golgi (GO:0000042)2.95863893
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90569001
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90400408
56signal peptide processing (GO:0006465)2.90005865
57exocrine pancreas development (GO:0031017)2.87860817
58protein targeting to vacuole (GO:0006623)2.87450647
59protein targeting to lysosome (GO:0006622)2.87450647
60establishment of protein localization to vacuole (GO:0072666)2.87450647
61cellular response to ethanol (GO:0071361)2.84154606
62retinol metabolic process (GO:0042572)2.83865928
63positive regulation of digestive system process (GO:0060456)2.81792922
64carnitine transmembrane transport (GO:1902603)2.81676772
65righting reflex (GO:0060013)2.81491519
66copper ion transport (GO:0006825)2.80519243
67positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.80343469
68quaternary ammonium group transport (GO:0015697)2.80006550
69prostate gland epithelium morphogenesis (GO:0060740)2.79392336
70amino-acid betaine transport (GO:0015838)2.75085211
71carnitine transport (GO:0015879)2.75085211
72cellular ketone body metabolic process (GO:0046950)2.75054992
73DNA methylation involved in gamete generation (GO:0043046)2.74698029
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72912921
75regulation of endocrine process (GO:0044060)2.72601005
76adenosine metabolic process (GO:0046085)2.71084758
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.65275213
78regulation of membrane lipid distribution (GO:0097035)2.64215957
79positive regulation of developmental pigmentation (GO:0048087)2.64070979
80terpenoid biosynthetic process (GO:0016114)2.63226258
81regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.62895698
82positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.62895698
83lipid translocation (GO:0034204)2.59749853
84phospholipid translocation (GO:0045332)2.59749853
85toxin transport (GO:1901998)2.59446772
86neural tube formation (GO:0001841)2.59019782
87protein localization to Golgi apparatus (GO:0034067)2.58234971
88branched-chain amino acid catabolic process (GO:0009083)2.57278848
89positive regulation of glycogen metabolic process (GO:0070875)2.57113537
90misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.56139336
91intestinal epithelial cell development (GO:0060576)2.51711155
92histone H3-K4 trimethylation (GO:0080182)2.51007024
93indole-containing compound metabolic process (GO:0042430)2.49451370
94pharyngeal system development (GO:0060037)2.49124096
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.48264108
96positive regulation of fatty acid oxidation (GO:0046321)2.46466492
97snRNA transcription (GO:0009301)2.46068285
98cellular biogenic amine biosynthetic process (GO:0042401)2.45972199
99amine biosynthetic process (GO:0009309)2.45209435
100mammary gland development (GO:0030879)2.44039750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.84561415
2PIAS1_25552417_ChIP-Seq_VCAP_Human3.34906506
3VDR_22108803_ChIP-Seq_LS180_Human3.10206830
4AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human3.00899690
5ZNF274_21170338_ChIP-Seq_K562_Hela2.95495505
6IGF1R_20145208_ChIP-Seq_DFB_Human2.66002270
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53917398
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48088045
9GBX2_23144817_ChIP-Seq_PC3_Human2.40049162
10AR_21572438_ChIP-Seq_LNCaP_Human2.33204615
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28000994
12AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.22017281
13EZH2_22144423_ChIP-Seq_EOC_Human2.15277595
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15195117
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07378494
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06313555
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05123347
18ER_23166858_ChIP-Seq_MCF-7_Human1.97571252
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96485699
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91250734
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89764182
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.86021570
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.85932066
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.83322906
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83041942
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81380888
27TAF15_26573619_Chip-Seq_HEK293_Human1.79337278
28AHR_22903824_ChIP-Seq_MCF-7_Human1.75693982
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72967570
30P300_19829295_ChIP-Seq_ESCs_Human1.71948417
31SMAD4_21799915_ChIP-Seq_A2780_Human1.66688642
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65482795
33CBP_20019798_ChIP-Seq_JUKART_Human1.65482795
34EWS_26573619_Chip-Seq_HEK293_Human1.64005383
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63792748
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63792748
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63195924
38TCF4_23295773_ChIP-Seq_U87_Human1.63000257
39STAT3_23295773_ChIP-Seq_U87_Human1.62134898
40AR_21909140_ChIP-Seq_LNCAP_Human1.59775296
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.58211841
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58113973
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55305972
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52484004
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49301221
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48308314
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46096094
48AR_25329375_ChIP-Seq_VCAP_Human1.45972234
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.44510559
50BCAT_22108803_ChIP-Seq_LS180_Human1.43404973
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42853845
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42359000
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41155530
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38472503
55RUNX2_22187159_ChIP-Seq_PCA_Human1.38198426
56TCF4_22108803_ChIP-Seq_LS180_Human1.37198246
57IRF1_19129219_ChIP-ChIP_H3396_Human1.36464383
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34286588
59FOXA1_25552417_ChIP-Seq_VCAP_Human1.31730094
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.30958048
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.26088510
62RXR_22108803_ChIP-Seq_LS180_Human1.24697970
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.23030765
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.21316906
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.19566708
66DROSHA_22980978_ChIP-Seq_HELA_Human1.18434019
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17318390
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17030948
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16526610
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.16027049
71OCT1_27270436_Chip-Seq_PROSTATE_Human1.14769180
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14415604
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14250054
74CDX2_22108803_ChIP-Seq_LS180_Human1.13671938
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11517452
76FUS_26573619_Chip-Seq_HEK293_Human1.08987626
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08942814
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08766079
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08766079
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08739577
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07648762
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07588976
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07341002
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06977111
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.05489399
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05069183
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.03558861
88TP53_16413492_ChIP-PET_HCT116_Human1.03152794
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.02953422
90AR_20517297_ChIP-Seq_VCAP_Human1.02635231
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.01909293
92TBL1_22424771_ChIP-Seq_293T_Human0.98582852
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96440741
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94814928
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.94626435
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.94594199
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92725159
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.92100043
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91673129
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.91227881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after5.24033987
2MP0005167_abnormal_blood-brain_barrier4.61390362
3MP0004043_abnormal_pH_regulation4.57622319
4MP0001968_abnormal_touch/_nociception4.02671226
5MP0003011_delayed_dark_adaptation3.54593601
6MP0002234_abnormal_pharynx_morphology3.28326446
7MP0002735_abnormal_chemical_nociception3.20437938
8MP0008057_abnormal_DNA_replication3.16474997
9MP0005646_abnormal_pituitary_gland2.43738243
10MP0003045_fibrosis2.41858590
11MP0005551_abnormal_eye_electrophysiolog2.22834286
12MP0005310_abnormal_salivary_gland1.92917958
13MP0005670_abnormal_white_adipose1.91745110
14MP0001501_abnormal_sleep_pattern1.83940931
15MP0002733_abnormal_thermal_nociception1.79062188
16MP0003718_maternal_effect1.71294342
17MP0003195_calcinosis1.51862337
18MP0003136_yellow_coat_color1.51817089
19MP0001756_abnormal_urination1.48132563
20MP0000383_abnormal_hair_follicle1.46992667
21MP0000230_abnormal_systemic_arterial1.46162351
22MP0001664_abnormal_digestion1.45508952
23MP0005085_abnormal_gallbladder_physiolo1.45419026
24MP0002876_abnormal_thyroid_physiology1.38798774
25MP0003646_muscle_fatigue1.38493985
26MP0000538_abnormal_urinary_bladder1.34015919
27MP0005253_abnormal_eye_physiology1.33705060
28MP0001765_abnormal_ion_homeostasis1.32728049
29MP0005647_abnormal_sex_gland1.30882119
30MP0000631_abnormal_neuroendocrine_gland1.29450561
31MP0002166_altered_tumor_susceptibility1.27536266
32MP0001970_abnormal_pain_threshold1.25867039
33MP0005395_other_phenotype1.23370595
34MP0001666_abnormal_nutrient_absorption1.20563916
35MP0002138_abnormal_hepatobiliary_system1.19369992
36MP0002822_catalepsy1.16439123
37MP0004145_abnormal_muscle_electrophysio1.13348040
38MP0005410_abnormal_fertilization1.11300283
39MP0003698_abnormal_male_reproductive1.09768327
40MP0002168_other_aberrant_phenotype1.08943106
41MP0000613_abnormal_salivary_gland1.08889482
42MP0008995_early_reproductive_senescence1.08733167
43MP0008877_abnormal_DNA_methylation1.08656486
44MP0002090_abnormal_vision1.07353465
45MP0010329_abnormal_lipoprotein_level1.06979573
46MP0005220_abnormal_exocrine_pancreas1.02326276
47MP0005636_abnormal_mineral_homeostasis1.01837124
48MP0002102_abnormal_ear_morphology1.01639257
49MP0000569_abnormal_digit_pigmentation1.00339286
50MP0002653_abnormal_ependyma_morphology0.99258384
51MP0003937_abnormal_limbs/digits/tail_de0.99159421
52MP0001188_hyperpigmentation0.99139437
53MP0002557_abnormal_social/conspecific_i0.97690021
54MP0005360_urolithiasis0.96628247
55MP0000516_abnormal_urinary_system0.96467193
56MP0005367_renal/urinary_system_phenotyp0.96467193
57MP0008961_abnormal_basal_metabolism0.94680398
58MP0010386_abnormal_urinary_bladder0.94065361
59MP0001486_abnormal_startle_reflex0.93799658
60MP0000427_abnormal_hair_cycle0.93381203
61MP0003633_abnormal_nervous_system0.93231999
62MP0004085_abnormal_heartbeat0.92273829
63MP0001873_stomach_inflammation0.91733292
64MP0001929_abnormal_gametogenesis0.91513124
65MP0003879_abnormal_hair_cell0.89133294
66MP0000372_irregular_coat_pigmentation0.88950568
67MP0002837_dystrophic_cardiac_calcinosis0.88159715
68MP0005645_abnormal_hypothalamus_physiol0.87901451
69MP0002067_abnormal_sensory_capabilities0.87698336
70MP0004858_abnormal_nervous_system0.86060404
71MP0002160_abnormal_reproductive_system0.84237952
72MP0001485_abnormal_pinna_reflex0.84210782
73MP0003950_abnormal_plasma_membrane0.82614940
74MP0004742_abnormal_vestibular_system0.80675855
75MP0003890_abnormal_embryonic-extraembry0.79946738
76MP0004036_abnormal_muscle_relaxation0.79413438
77MP0003936_abnormal_reproductive_system0.79191785
78MP0001879_abnormal_lymphatic_vessel0.79069895
79MP0004084_abnormal_cardiac_muscle0.78702434
80MP0004510_myositis0.76917417
81MP0000653_abnormal_sex_gland0.76374171
82MP0006072_abnormal_retinal_apoptosis0.75852871
83MP0003866_abnormal_defecation0.75587544
84MP0001919_abnormal_reproductive_system0.75134168
85MP0002928_abnormal_bile_duct0.75079700
86MP0005248_abnormal_Harderian_gland0.74920082
87MP0002909_abnormal_adrenal_gland0.74337296
88MP0003943_abnormal_hepatobiliary_system0.73770379
89MP0003137_abnormal_impulse_conducting0.73355125
90MP0003953_abnormal_hormone_level0.73049048
91MP0002210_abnormal_sex_determination0.71665959
92MP0005389_reproductive_system_phenotype0.70175348
93MP0002136_abnormal_kidney_physiology0.70131447
94MP0002006_tumorigenesis0.70069425
95MP0004019_abnormal_vitamin_homeostasis0.69995582
96MP0008872_abnormal_physiological_respon0.68875426
97MP0001984_abnormal_olfaction0.67125620
98MP0000371_diluted_coat_color0.66731686
99MP0009703_decreased_birth_body0.66327968
100MP0004924_abnormal_behavior0.66055569

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.48035971
2Gaze-evoked nystagmus (HP:0000640)4.27200668
3Pancreatic cysts (HP:0001737)4.09394362
4Amelogenesis imperfecta (HP:0000705)3.97124167
5Progressive cerebellar ataxia (HP:0002073)3.79966249
6Hyperventilation (HP:0002883)3.70294395
7Pancreatic fibrosis (HP:0100732)3.48068393
8True hermaphroditism (HP:0010459)3.39801556
9Abnormality of the nasal septum (HP:0000419)3.37995745
10Generalized hypopigmentation of hair (HP:0011358)3.33541498
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.33474561
12Broad-based gait (HP:0002136)3.12831572
13Chronic hepatic failure (HP:0100626)3.11608894
14Hyperglycinuria (HP:0003108)2.99883874
15Molar tooth sign on MRI (HP:0002419)2.97635668
16Abnormality of midbrain morphology (HP:0002418)2.97635668
17Cystic liver disease (HP:0006706)2.88209412
18Fair hair (HP:0002286)2.88167196
19Nephronophthisis (HP:0000090)2.86809844
20Abnormality of the renal medulla (HP:0100957)2.81514364
21Abnormality of the axillary hair (HP:0100134)2.78988302
22Abnormality of secondary sexual hair (HP:0009888)2.78988302
23Clumsiness (HP:0002312)2.75605074
24Decreased circulating renin level (HP:0003351)2.70316895
25Abnormality of the renal cortex (HP:0011035)2.65142012
26Protruding tongue (HP:0010808)2.63003682
27Severe Myopia (HP:0011003)2.61606370
28Attenuation of retinal blood vessels (HP:0007843)2.61481996
29Hypoplasia of the pons (HP:0012110)2.50938037
30Neoplasm of the heart (HP:0100544)2.46414310
31Cerebellar dysplasia (HP:0007033)2.44198555
32Hypothermia (HP:0002045)2.40791680
33Tented upper lip vermilion (HP:0010804)2.40176622
34Abnormality of the pons (HP:0007361)2.35613946
35Medial flaring of the eyebrow (HP:0010747)2.27947202
36Hypoplastic nipples (HP:0002557)2.26916486
37Type II lissencephaly (HP:0007260)2.20131157
38Abnormality of glycine metabolism (HP:0010895)2.14112663
39Abnormality of serine family amino acid metabolism (HP:0010894)2.14112663
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.11343995
41Absent radius (HP:0003974)2.10031634
42Abnormality of the proximal phalanges of the hand (HP:0009834)2.09055379
43Tubular atrophy (HP:0000092)2.06488552
44Congenital primary aphakia (HP:0007707)2.02859622
45Dysmetric saccades (HP:0000641)2.01751343
46Short tibia (HP:0005736)2.01312942
47Absent forearm bone (HP:0003953)2.00310522
48Aplasia involving forearm bones (HP:0009822)2.00310522
49Gait imbalance (HP:0002141)1.98301702
50Fibular aplasia (HP:0002990)1.97234772
51Gonadotropin excess (HP:0000837)1.95893363
52Hypoplasia of the ulna (HP:0003022)1.94319089
53Renal tubular acidosis (HP:0001947)1.93420431
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92019211
55Aplasia/Hypoplasia of the ulna (HP:0006495)1.91742786
56Genital tract atresia (HP:0001827)1.90899128
57Congenital stationary night blindness (HP:0007642)1.90356932
58Postaxial foot polydactyly (HP:0001830)1.89130043
59Vaginal atresia (HP:0000148)1.88107158
60Hypoplastic labia majora (HP:0000059)1.87544091
61Laryngomalacia (HP:0001601)1.86905132
62Ketosis (HP:0001946)1.86314473
63Ketoacidosis (HP:0001993)1.86196841
64Sparse lateral eyebrow (HP:0005338)1.84703369
65Poor coordination (HP:0002370)1.83856048
66Abolished electroretinogram (ERG) (HP:0000550)1.83853177
67Nephrogenic diabetes insipidus (HP:0009806)1.82916223
68Stomach cancer (HP:0012126)1.82307310
69Abnormality of the ischium (HP:0003174)1.81429196
70Bronchomalacia (HP:0002780)1.81384454
71Bony spicule pigmentary retinopathy (HP:0007737)1.81349852
72Aortic aneurysm (HP:0004942)1.81202933
73Anal stenosis (HP:0002025)1.80237834
74Abnormality of the fingertips (HP:0001211)1.75747736
75Absent/shortened dynein arms (HP:0200106)1.74899095
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.74899095
77Abnormality of the labia majora (HP:0012881)1.74328628
78Aplasia of the musculature (HP:0100854)1.72568792
79Shawl scrotum (HP:0000049)1.72070258
80Male pseudohermaphroditism (HP:0000037)1.71949142
81Polydipsia (HP:0001959)1.71787376
82Abnormal drinking behavior (HP:0030082)1.71787376
83Optic nerve hypoplasia (HP:0000609)1.71203135
84Prolonged QT interval (HP:0001657)1.70354538
85Anencephaly (HP:0002323)1.69773546
86Breast hypoplasia (HP:0003187)1.69530842
87Absent speech (HP:0001344)1.69175191
88Renal cortical cysts (HP:0000803)1.68986726
89Aplasia/Hypoplasia of the fibula (HP:0006492)1.66563670
90Aortic regurgitation (HP:0001659)1.66184903
91Furrowed tongue (HP:0000221)1.65157394
92Tubulointerstitial nephritis (HP:0001970)1.64690610
93Widely spaced teeth (HP:0000687)1.64179198
94Astigmatism (HP:0000483)1.64082491
95Postaxial hand polydactyly (HP:0001162)1.63822144
96Depressed nasal tip (HP:0000437)1.63667234
97Lip pit (HP:0100267)1.63552335
98Congenital hepatic fibrosis (HP:0002612)1.63139893
99Keratoconus (HP:0000563)1.60633554
100Increased corneal curvature (HP:0100692)1.60633554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.85080000
2FRK6.70901007
3TAOK32.88069921
4BMPR1B2.65639492
5STK38L2.43966980
6CAMK1D2.26542369
7SGK22.10634307
8ACVR1B2.08751167
9TNK21.96353237
10MYLK1.92489279
11DAPK21.91380229
12CAMK1G1.86360883
13WNK41.72337624
14EEF2K1.69374524
15LATS11.68906029
16WNK31.56051157
17MAP3K41.49799892
18MAPK131.49316232
19SGK2231.48122853
20SGK4941.48122853
21MAPKAPK31.45864962
22MKNK21.44294202
23STK381.43348497
24BRSK21.34558349
25INSRR1.34238216
26STK391.32043410
27NUAK11.29810061
28NLK1.18843810
29DMPK1.15076847
30PIK3CG1.12664549
31SGK31.12601582
32EPHA31.11890484
33ADRBK21.05092262
34OXSR11.03510991
35PRKAA21.01457191
36MAP4K21.00328929
37NTRK30.98064476
38GRK10.95275118
39ERBB20.90642343
40ZAK0.85958820
41TRPM70.85441939
42STK30.81045663
43PRKAA10.76197888
44MARK20.71911835
45PIK3CA0.71247980
46MUSK0.68680963
47CDC42BPA0.67973369
48OBSCN0.66437446
49PRKD30.65683427
50PKN20.60287431
51MAP3K70.57071026
52MAP2K60.55886596
53SGK10.54066103
54TEC0.53785087
55FER0.53663942
56PRKCE0.53310585
57TNIK0.52917148
58CHUK0.51832787
59TXK0.51474658
60MELK0.51005718
61CDK120.50019603
62WNK10.49952775
63MTOR0.49415610
64TGFBR10.48709493
65BRD40.48055177
66CAMK10.45537555
67PAK30.44818123
68EIF2AK30.44423605
69MKNK10.42493792
70ADRBK10.40701780
71MAPKAPK50.39091168
72NEK60.37598788
73PLK40.36965852
74BCR0.36277313
75ERBB30.36169110
76MARK10.35380733
77PAK20.35126074
78PTK2B0.33399967
79CSNK1A1L0.33026559
80GSK3B0.32529670
81KDR0.32315554
82MAP2K70.31967241
83FGFR20.30942055
84RPS6KA30.30253540
85MAPK10.29811058
86DAPK10.29678977
87AKT10.29207906
88PRKACA0.29041299
89MAPK80.28414806
90MAPK150.28171580
91GRK70.26795261
92RPS6KA50.26537649
93CSNK1D0.26533432
94PKN10.26353111
95TLK10.26217182
96GSK3A0.25837047
97ROCK10.25818617
98PINK10.25081977
99CASK0.24325459
100PRKACB0.24317862

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020103.38242870
2Butanoate metabolism_Homo sapiens_hsa006503.24944778
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59128871
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.30154409
5beta-Alanine metabolism_Homo sapiens_hsa004102.29153341
6Linoleic acid metabolism_Homo sapiens_hsa005912.28271275
7Olfactory transduction_Homo sapiens_hsa047402.26028891
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08461024
9Tryptophan metabolism_Homo sapiens_hsa003801.96787979
10Propanoate metabolism_Homo sapiens_hsa006401.96332172
11Fatty acid biosynthesis_Homo sapiens_hsa000611.88613544
12Vitamin digestion and absorption_Homo sapiens_hsa049771.78862319
13Nitrogen metabolism_Homo sapiens_hsa009101.75364266
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.72576650
15Phototransduction_Homo sapiens_hsa047441.68510458
16Lysine degradation_Homo sapiens_hsa003101.67777414
17Mineral absorption_Homo sapiens_hsa049781.66861384
18Bile secretion_Homo sapiens_hsa049761.60307057
19Histidine metabolism_Homo sapiens_hsa003401.57926595
20Ovarian steroidogenesis_Homo sapiens_hsa049131.53888458
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51285378
22Homologous recombination_Homo sapiens_hsa034401.47961970
23Circadian rhythm_Homo sapiens_hsa047101.46301578
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44814280
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.44676723
26Retinol metabolism_Homo sapiens_hsa008301.42693869
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42689622
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42529992
29Fatty acid metabolism_Homo sapiens_hsa012121.42438064
30Nicotine addiction_Homo sapiens_hsa050331.39063239
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36907785
32Chemical carcinogenesis_Homo sapiens_hsa052041.24962610
33Taste transduction_Homo sapiens_hsa047421.24901590
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23536246
35Ether lipid metabolism_Homo sapiens_hsa005651.23272279
36Prostate cancer_Homo sapiens_hsa052151.22726806
37Fanconi anemia pathway_Homo sapiens_hsa034601.18577317
38Salivary secretion_Homo sapiens_hsa049701.17595284
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03054493
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02277693
41Serotonergic synapse_Homo sapiens_hsa047260.99474972
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99355622
43Insulin secretion_Homo sapiens_hsa049110.97774041
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95854003
45Fatty acid degradation_Homo sapiens_hsa000710.95169671
46Peroxisome_Homo sapiens_hsa041460.93810853
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92614677
48Type II diabetes mellitus_Homo sapiens_hsa049300.89741670
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89716230
50cAMP signaling pathway_Homo sapiens_hsa040240.89075478
51Arachidonic acid metabolism_Homo sapiens_hsa005900.85916954
52Morphine addiction_Homo sapiens_hsa050320.84529096
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83577861
54Renin-angiotensin system_Homo sapiens_hsa046140.81196549
55Caffeine metabolism_Homo sapiens_hsa002320.78124078
56Calcium signaling pathway_Homo sapiens_hsa040200.77716664
57One carbon pool by folate_Homo sapiens_hsa006700.77133871
58mTOR signaling pathway_Homo sapiens_hsa041500.76069335
59Amphetamine addiction_Homo sapiens_hsa050310.76009760
60Circadian entrainment_Homo sapiens_hsa047130.75430377
61RNA polymerase_Homo sapiens_hsa030200.74811820
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.74494927
63Glutamatergic synapse_Homo sapiens_hsa047240.74127945
64Insulin resistance_Homo sapiens_hsa049310.73174350
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71841131
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71587005
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68744718
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.67658195
69Renin secretion_Homo sapiens_hsa049240.66832354
70FoxO signaling pathway_Homo sapiens_hsa040680.66281159
71Dorso-ventral axis formation_Homo sapiens_hsa043200.66263562
72AMPK signaling pathway_Homo sapiens_hsa041520.65744891
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64876578
74Glycerolipid metabolism_Homo sapiens_hsa005610.62590148
75Selenocompound metabolism_Homo sapiens_hsa004500.62486221
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61354048
77Pancreatic secretion_Homo sapiens_hsa049720.60462934
78Phenylalanine metabolism_Homo sapiens_hsa003600.58188716
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57744577
80MicroRNAs in cancer_Homo sapiens_hsa052060.57703096
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55824259
82Cocaine addiction_Homo sapiens_hsa050300.55728892
83Long-term depression_Homo sapiens_hsa047300.55547711
84Purine metabolism_Homo sapiens_hsa002300.55311157
85Oxytocin signaling pathway_Homo sapiens_hsa049210.54772858
86Tight junction_Homo sapiens_hsa045300.52046250
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.51872627
88Sphingolipid metabolism_Homo sapiens_hsa006000.51598208
89Fat digestion and absorption_Homo sapiens_hsa049750.50073748
90Basal transcription factors_Homo sapiens_hsa030220.48961776
91Non-homologous end-joining_Homo sapiens_hsa034500.48744379
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47405653
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45651638
94Glucagon signaling pathway_Homo sapiens_hsa049220.45400283
95TGF-beta signaling pathway_Homo sapiens_hsa043500.44994728
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43866978
97Dopaminergic synapse_Homo sapiens_hsa047280.42977246
98Hedgehog signaling pathway_Homo sapiens_hsa043400.42285762
99Arginine and proline metabolism_Homo sapiens_hsa003300.42091580
100Cholinergic synapse_Homo sapiens_hsa047250.40850733

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