POTEG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.49263332
2motile cilium assembly (GO:0044458)9.23550220
3cilium movement (GO:0003341)9.14088860
4reproduction (GO:0000003)9.10239496
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.93871452
6male meiosis (GO:0007140)8.79666931
7spermatid development (GO:0007286)8.51828313
8regulation of cilium movement (GO:0003352)8.16130027
9synaptonemal complex organization (GO:0070193)7.97712275
10synaptonemal complex assembly (GO:0007130)7.86315747
11sperm capacitation (GO:0048240)7.78666165
12single fertilization (GO:0007338)7.20656908
13Arp2/3 complex-mediated actin nucleation (GO:0034314)6.63245075
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.60776115
15actin nucleation (GO:0045010)6.12796061
16ventricular system development (GO:0021591)6.07764244
17DNA deamination (GO:0045006)6.04861111
18DNA methylation involved in gamete generation (GO:0043046)6.03847249
19fertilization (GO:0009566)6.01718205
20adaptation of signaling pathway (GO:0023058)5.76812134
21chromosome organization involved in meiosis (GO:0070192)5.61798561
22spermatogenesis (GO:0007283)5.51183027
23male gamete generation (GO:0048232)5.49511145
24cytidine metabolic process (GO:0046087)5.43975105
25cytidine catabolic process (GO:0006216)5.43975105
26cytidine deamination (GO:0009972)5.43975105
27microtubule severing (GO:0051013)5.40177872
28negative regulation of inclusion body assembly (GO:0090084)5.28446331
29cell recognition (GO:0008037)5.26964727
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.11659283
31male meiosis I (GO:0007141)5.09948785
32gamete generation (GO:0007276)5.04743562
33organic cation transport (GO:0015695)4.97630831
34germ cell development (GO:0007281)4.90474024
35meiotic nuclear division (GO:0007126)4.90116370
36pyrimidine ribonucleoside catabolic process (GO:0046133)4.83672880
37regulation of microtubule-based movement (GO:0060632)4.81412469
38protein localization to cilium (GO:0061512)4.77909334
39microtubule depolymerization (GO:0007019)4.77836165
40calcium ion-dependent exocytosis (GO:0017156)4.68630626
41protein polyglutamylation (GO:0018095)4.64773387
42seminiferous tubule development (GO:0072520)4.54396281
43regulation of inclusion body assembly (GO:0090083)4.35125612
44meiotic cell cycle (GO:0051321)4.34299863
45regulation of regulatory T cell differentiation (GO:0045589)4.32724161
46spermatid nucleus differentiation (GO:0007289)4.32714604
47left/right pattern formation (GO:0060972)4.30015833
48retina homeostasis (GO:0001895)4.17488652
49intraciliary transport (GO:0042073)4.12958602
50sequestering of actin monomers (GO:0042989)4.12402135
51monoubiquitinated protein deubiquitination (GO:0035520)4.06563686
52meiosis I (GO:0007127)4.05457549
53positive regulation of T cell cytokine production (GO:0002726)3.99303989
54cellular response to interleukin-15 (GO:0071350)3.97344436
55multicellular organismal reproductive process (GO:0048609)3.93288836
56negative T cell selection (GO:0043383)3.91101324
57negative regulation of stress fiber assembly (GO:0051497)3.85512609
58negative regulation of sodium ion transport (GO:0010766)3.83087558
59gene silencing by RNA (GO:0031047)3.78669384
60regulation of memory T cell differentiation (GO:0043380)3.77707890
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75763399
62regulation of T cell receptor signaling pathway (GO:0050856)3.68775135
63negative regulation of T cell apoptotic process (GO:0070233)3.67996750
64microtubule-based movement (GO:0007018)3.67799580
65genitalia morphogenesis (GO:0035112)3.67371128
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.62721697
67negative regulation of organelle assembly (GO:1902116)3.61690123
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57141239
69synapsis (GO:0007129)3.56920869
70adenosine metabolic process (GO:0046085)3.54027299
71regulation of defense response to virus by host (GO:0050691)3.52936316
72carnitine transmembrane transport (GO:1902603)3.52046717
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.51714733
74positive regulation of defense response to virus by host (GO:0002230)3.48431257
75positive T cell selection (GO:0043368)3.48105425
76regulation of T cell mediated cytotoxicity (GO:0001914)3.47088695
77carnitine transport (GO:0015879)3.46006242
78amino-acid betaine transport (GO:0015838)3.46006242
79regulation of gamma-delta T cell differentiation (GO:0045586)3.41718062
80phospholipid scrambling (GO:0017121)3.37051632
81axoneme assembly (GO:0035082)3.33467329
82cilium organization (GO:0044782)3.33216942
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.32803677
84positive regulation of natural killer cell mediated immunity (GO:0002717)3.30468219
85regulation of leukocyte mediated cytotoxicity (GO:0001910)3.29352116
86tryptophan catabolic process (GO:0006569)3.28038787
87indole-containing compound catabolic process (GO:0042436)3.28038787
88indolalkylamine catabolic process (GO:0046218)3.28038787
89chaperone-mediated protein complex assembly (GO:0051131)3.27137552
90kynurenine metabolic process (GO:0070189)3.26752687
91negative regulation of systemic arterial blood pressure (GO:0003085)3.26449089
92regulation of B cell receptor signaling pathway (GO:0050855)3.26048513
93positive regulation of T cell mediated immunity (GO:0002711)3.24898833
94multicellular organismal development (GO:0007275)3.24363945
95positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.22214012
96regulation of centriole replication (GO:0046599)3.21484116
97positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.21055180
98T cell receptor signaling pathway (GO:0050852)3.20118163
99peptidyl-glutamic acid modification (GO:0018200)3.19981203
100cilium assembly (GO:0042384)3.19815228
101negative regulation of actin filament bundle assembly (GO:0032232)3.19524732
102cellular component assembly involved in morphogenesis (GO:0010927)3.13810207
103negative thymic T cell selection (GO:0045060)3.13506141
104cilium morphogenesis (GO:0060271)3.10256503
105alditol metabolic process (GO:0019400)3.07659270
106positive regulation of cell killing (GO:0031343)3.07520576
107positive regulation of calcium-mediated signaling (GO:0050850)3.06884321
108lactate metabolic process (GO:0006089)3.06337934
109meiotic cell cycle process (GO:1903046)3.04752693
110regulation of T cell cytokine production (GO:0002724)3.00663564
111nucleoside diphosphate phosphorylation (GO:0006165)3.00605674
112regulation of activation of Janus kinase activity (GO:0010533)2.97581417
113indolalkylamine metabolic process (GO:0006586)2.95788098
114positive regulation of chemokine secretion (GO:0090197)2.92781753
115cytolysis (GO:0019835)2.91980178
116regulation of cell killing (GO:0031341)2.91884094
117benzene-containing compound metabolic process (GO:0042537)2.91214809
118mast cell activation (GO:0045576)2.91104037
119regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.89982771
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89722886
121negative regulation of cell killing (GO:0031342)2.89722886
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89165226
123regulation of spindle checkpoint (GO:0090231)2.88780998
124glycerol ether metabolic process (GO:0006662)2.87183909
125glycerol metabolic process (GO:0006071)2.86277218
126negative regulation of viral genome replication (GO:0045071)2.85446092
127positive thymic T cell selection (GO:0045059)2.84944482
128protein K11-linked deubiquitination (GO:0035871)2.83537003
129regulation of T cell mediated immunity (GO:0002709)2.81052078
130negative regulation of mast cell activation (GO:0033004)2.79045593
131polyol catabolic process (GO:0046174)2.77729650
132GTP biosynthetic process (GO:0006183)2.77627084
133regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.74495805
134regulation of natural killer cell mediated immunity (GO:0002715)2.74495805
135mannosylation (GO:0097502)2.72826647
136T cell migration (GO:0072678)2.72659949
137GPI anchor metabolic process (GO:0006505)2.72364426
138regulation of alpha-beta T cell proliferation (GO:0046640)2.69905228
139cellular ketone body metabolic process (GO:0046950)2.67445574
140retinal metabolic process (GO:0042574)2.66665066
141negative regulation of protein localization to cell surface (GO:2000009)2.66621744
142ether metabolic process (GO:0018904)2.66301911
143sulfation (GO:0051923)2.64793420
144positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64302252
145positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.63673340
146positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.63275806
147regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.63275806
148tryptophan metabolic process (GO:0006568)2.63106979
149regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.62663178
150positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.62663178
151regulation of gamma-delta T cell activation (GO:0046643)2.62307750
152negative regulation of lymphocyte apoptotic process (GO:0070229)2.62208807
153rRNA catabolic process (GO:0016075)2.62156745
154mature B cell differentiation (GO:0002335)2.61988551
155response to pheromone (GO:0019236)2.61558506
156positive regulation of prostaglandin secretion (GO:0032308)2.59627803
157regulation of endocrine process (GO:0044060)2.59294669
158centriole replication (GO:0007099)2.58682709
159GPI anchor biosynthetic process (GO:0006506)2.58462314
160chromosome condensation (GO:0030261)2.55925427
161positive regulation of interleukin-4 production (GO:0032753)2.55307824
162regulation of interleukin-8 secretion (GO:2000482)2.55298517
163gene silencing (GO:0016458)2.53800755
164regulation of interleukin-12 biosynthetic process (GO:0045075)2.52323379
165T cell costimulation (GO:0031295)2.52105322
166amine catabolic process (GO:0009310)2.51588347
167cellular biogenic amine catabolic process (GO:0042402)2.51588347
168antigen receptor-mediated signaling pathway (GO:0050851)2.50862350
169positive regulation of T cell differentiation in thymus (GO:0033089)2.50352179
170mitotic sister chromatid cohesion (GO:0007064)2.49968147
171regulation of acrosome reaction (GO:0060046)2.49224183
172lymphocyte costimulation (GO:0031294)2.49169620
173DNA packaging (GO:0006323)2.48976031
174positive regulation of uterine smooth muscle contraction (GO:0070474)2.48083297
175microtubule polymerization or depolymerization (GO:0031109)2.46248339
176UTP biosynthetic process (GO:0006228)2.43860814
177negative regulation of DNA repair (GO:0045738)2.43777219
178centriole assembly (GO:0098534)2.42801761
179regulation of protein polyubiquitination (GO:1902914)2.42615920
180peptidyl-lysine dimethylation (GO:0018027)2.39934884
181quaternary ammonium group transport (GO:0015697)2.39928266
182nuclear pore complex assembly (GO:0051292)2.36402622
183histone exchange (GO:0043486)2.35947439
184glycolytic process (GO:0006096)2.34180419
185cilium or flagellum-dependent cell motility (GO:0001539)16.2434168
186acrosome assembly (GO:0001675)12.6950817
187fusion of sperm to egg plasma membrane (GO:0007342)12.3978377
188cell wall macromolecule catabolic process (GO:0016998)11.8067329
189cell wall macromolecule metabolic process (GO:0044036)11.8067329
190sperm motility (GO:0030317)11.7105660
191sperm-egg recognition (GO:0035036)11.5561864
192multicellular organism reproduction (GO:0032504)11.3031509
193axonemal dynein complex assembly (GO:0070286)11.1691641
194binding of sperm to zona pellucida (GO:0007339)10.4944941
195cell-cell recognition (GO:0009988)10.3678307
196piRNA metabolic process (GO:0034587)10.2611335
197acrosome reaction (GO:0007340)10.0573776
198epithelial cilium movement (GO:0003351)10.0444512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.82873744
2EZH2_22144423_ChIP-Seq_EOC_Human5.68822932
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.27934387
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83986745
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.56878523
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87133847
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60409964
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57053298
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.55478547
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48318572
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27169998
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26127770
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.25379873
14RUNX_20019798_ChIP-Seq_JUKART_Human2.23394313
15ZNF274_21170338_ChIP-Seq_K562_Hela2.19834943
16VDR_22108803_ChIP-Seq_LS180_Human2.17928863
17IGF1R_20145208_ChIP-Seq_DFB_Human2.15397648
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.09743195
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04220943
20GATA3_26560356_Chip-Seq_TH2_Human2.02939303
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2830440
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98507169
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.94847062
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94060340
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91480897
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.89468814
27MYB_26560356_Chip-Seq_TH2_Human1.88818203
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.81679863
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78247129
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77855336
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77565992
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77142914
33CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75426564
34GATA3_27048872_Chip-Seq_THYMUS_Human1.73950281
35GBX2_23144817_ChIP-Seq_PC3_Human1.73703859
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72934676
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69448805
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66620595
39AR_20517297_ChIP-Seq_VCAP_Human1.64729964
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62451796
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.62144320
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.61482001
43IRF1_19129219_ChIP-ChIP_H3396_Human1.61319513
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.58604482
45* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56338408
46REST_21632747_ChIP-Seq_MESCs_Mouse1.52960853
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51951477
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51677878
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49209796
50* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46101046
51* TAL1_26923725_Chip-Seq_HPCs_Mouse1.45594788
52STAT1_17558387_ChIP-Seq_HELA_Human1.45543880
53RNF2_27304074_Chip-Seq_NSC_Mouse1.44740974
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44043655
55KDM2B_26808549_Chip-Seq_REH_Human1.43342182
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.42248903
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42196989
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39265291
59* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38976484
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38915409
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37740847
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36408476
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35524022
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.34958473
65MYB_26560356_Chip-Seq_TH1_Human1.34574963
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31664021
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30072091
68* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29840568
69* CBP_20019798_ChIP-Seq_JUKART_Human1.29840568
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28443374
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.27619417
72AR_21572438_ChIP-Seq_LNCaP_Human1.27548688
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.26861272
74TP53_22573176_ChIP-Seq_HFKS_Human1.25924116
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24465020
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.24465020
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.24192280
78FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24070897
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.23874198
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22338338
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22151975
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22151975
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.21344098
84NCOR_22424771_ChIP-Seq_293T_Human1.20447164
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.19993899
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18470294
87P300_18555785_Chip-Seq_ESCs_Mouse1.18028221
88P53_22387025_ChIP-Seq_ESCs_Mouse1.17798811
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16264072
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16116841
91BCAT_22108803_ChIP-Seq_LS180_Human1.15908714
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.15479027
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14749689
94* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13885299
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13552056
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13412622
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12630988
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.12439650
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12083574
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.11992469
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11883769
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11849723
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.11732561
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.11363943
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10834432
106P300_19829295_ChIP-Seq_ESCs_Human1.10774339
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10603156
108LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10450938
109HOXB7_26014856_ChIP-Seq_BT474_Human1.10151993
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09121530
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09024136
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08805985
113RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08057411
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07485337
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07289468
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07221829
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05986697
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05956657
119SOX2_22085726_ChIP-Seq_NPCs_Mouse1.05913528
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05679973
121RXR_22108803_ChIP-Seq_LS180_Human1.05467005
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05446469
123GF1_26923725_Chip-Seq_HPCs_Mouse1.05100149
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05032847
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04858883
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.04733368
127PHF8_20622853_ChIP-Seq_HELA_Human1.03842674
128OCT4_20526341_ChIP-Seq_ESCs_Human1.03724985
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03129259
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02582518
131NFYA_21822215_ChIP-Seq_K562_Human1.02119538
132ER_23166858_ChIP-Seq_MCF-7_Human1.02095574
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01799000
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.00795424
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00151720
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99517035
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.99308538
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99089974
139AR_25329375_ChIP-Seq_VCAP_Human0.98896645
140TCF4_22108803_ChIP-Seq_LS180_Human0.98330385
141NFYB_21822215_ChIP-Seq_K562_Human0.98253063
142ETV1_20927104_ChIP-Seq_GIST48_Human0.98127254
143TBL1_22424771_ChIP-Seq_293T_Human0.98012004
144GATA3_21878914_ChIP-Seq_MCF-7_Human0.97996062
145VDR_23849224_ChIP-Seq_CD4+_Human0.97814060
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97472886
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.97282799
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96467535
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.96066140
150EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96002442
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.95848256
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95660453
153HNFA_21074721_ChIP-Seq_CACO-2_Human0.95371218
154PU1_27457419_Chip-Seq_LIVER_Mouse0.95029286
155* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94842381
156ERA_21632823_ChIP-Seq_H3396_Human0.94179067
157TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93763984
158CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93519856
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93168129
160SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92129613
161P53_21459846_ChIP-Seq_SAOS-2_Human0.90618361
162PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90433332
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89871931
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89188908
165TCF4_23295773_ChIP-Seq_U87_Human0.87351174
166NMYC_18555785_Chip-Seq_ESCs_Mouse0.86542124
167* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86443967
168FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85555708
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85273156
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85181836
171SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84318137
172* ESET_19884257_ChIP-Seq_ESCs_Mouse0.83767667
173SPI1_26923725_Chip-Seq_HPCs_Mouse0.83670721
174GF1B_26923725_Chip-Seq_HPCs_Mouse0.83519375
175SOX9_26525672_Chip-Seq_HEART_Mouse0.81036703
176TAF15_26573619_Chip-Seq_HEK293_Human0.80143456
177SMAD4_21799915_ChIP-Seq_A2780_Human0.79933120
178ERG_20517297_ChIP-Seq_VCAP_Human0.79384867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.79548760
2MP0001929_abnormal_gametogenesis5.27617294
3MP0005671_abnormal_response_to4.72877801
4MP0008877_abnormal_DNA_methylation4.50875653
5MP0002653_abnormal_ependyma_morphology4.28241313
6MP0002210_abnormal_sex_determination3.55834311
7MP0005623_abnormal_meninges_morphology3.23999992
8MP0003045_fibrosis3.16735305
9MP0002161_abnormal_fertility/fecundity3.08686864
10MP0001145_abnormal_male_reproductive3.04279538
11MP0002166_altered_tumor_susceptibility2.79658573
12MP0001835_abnormal_antigen_presentation2.78400075
13MP0005167_abnormal_blood-brain_barrier2.73689455
14MP0000653_abnormal_sex_gland2.62840185
15MP0003763_abnormal_thymus_physiology2.57631127
16MP0009046_muscle_twitch2.54978211
17MP0004043_abnormal_pH_regulation2.21094636
18MP0009785_altered_susceptibility_to2.16448605
19MP0001501_abnormal_sleep_pattern2.16132817
20MP0003866_abnormal_defecation2.15728958
21MP0000685_abnormal_immune_system2.11707363
22MP0002006_tumorigenesis2.00239840
23MP0005410_abnormal_fertilization14.9181186
24MP0002933_joint_inflammation1.94629461
25MP0008057_abnormal_DNA_replication1.90804916
26MP0005000_abnormal_immune_tolerance1.85865649
27MP0003724_increased_susceptibility_to1.84028604
28MP0003195_calcinosis1.83843657
29MP0001800_abnormal_humoral_immune1.78862016
30MP0004947_skin_inflammation1.76181048
31MP0002735_abnormal_chemical_nociception1.70220554
32MP0002723_abnormal_immune_serum1.68093004
33MP0001819_abnormal_immune_cell1.61231471
34MP0002282_abnormal_trachea_morphology1.61026087
35MP0005646_abnormal_pituitary_gland1.61013526
36MP0002420_abnormal_adaptive_immunity1.59496220
37MP0002160_abnormal_reproductive_system1.52939965
38MP0005025_abnormal_response_to1.51115539
39MP0002876_abnormal_thyroid_physiology1.48846951
40MP0001756_abnormal_urination1.47603990
41MP0001873_stomach_inflammation1.46893693
42MP0005645_abnormal_hypothalamus_physiol1.46742412
43MP0002837_dystrophic_cardiac_calcinosis1.45821306
44MP0004510_myositis1.45635202
45MP0002009_preneoplasia1.44228777
46MP0003646_muscle_fatigue1.44026960
47MP0001984_abnormal_olfaction1.42668186
48MP0002452_abnormal_antigen_presenting1.42557872
49MP0002822_catalepsy1.40197750
50MP0002405_respiratory_system_inflammati1.40069789
51MP0008058_abnormal_DNA_repair1.35357229
52MP0002148_abnormal_hypersensitivity_rea1.31502768
53MP0005085_abnormal_gallbladder_physiolo1.30122557
54MP0005310_abnormal_salivary_gland1.29172034
55MP0010155_abnormal_intestine_physiology1.24554271
56MP0003436_decreased_susceptibility_to1.22968645
57MP0008961_abnormal_basal_metabolism1.22747864
58MP0001919_abnormal_reproductive_system1.19224048
59MP0001542_abnormal_bone_strength1.18667063
60MP0000703_abnormal_thymus_morphology1.17428288
61MP0000230_abnormal_systemic_arterial1.17362877
62MP0002138_abnormal_hepatobiliary_system1.17218674
63MP0003011_delayed_dark_adaptation1.16924948
64MP0000716_abnormal_immune_system1.15240097
65MP0005670_abnormal_white_adipose1.09699450
66MP0000465_gastrointestinal_hemorrhage1.09133295
67MP0001845_abnormal_inflammatory_respons1.07601617
68MP0002398_abnormal_bone_marrow1.07126034
69MP0010386_abnormal_urinary_bladder1.06237218
70MP0002168_other_aberrant_phenotype1.04441419
71MP0001790_abnormal_immune_system1.04416542
72MP0005387_immune_system_phenotype1.04416542
73MP0000689_abnormal_spleen_morphology1.00791402
74MP0001664_abnormal_digestion0.99884779
75MP0004147_increased_porphyrin_level0.99805257
76MP0002638_abnormal_pupillary_reflex0.98837058
77MP0010094_abnormal_chromosome_stability0.98246559
78MP0003329_amyloid_beta_deposits0.95017903
79MP0002722_abnormal_immune_system0.93831024
80MP0009764_decreased_sensitivity_to0.93348521
81MP0001765_abnormal_ion_homeostasis0.92861075
82MP0004233_abnormal_muscle_weight0.92082147
83MP0002733_abnormal_thermal_nociception0.90943398
84MP0003878_abnormal_ear_physiology0.90429636
85MP0005377_hearing/vestibular/ear_phenot0.90429636
86MP0002136_abnormal_kidney_physiology0.89741909
87MP0005647_abnormal_sex_gland0.88306367
88MP0000538_abnormal_urinary_bladder0.87580766
89MP0001970_abnormal_pain_threshold0.86971339
90MP0004134_abnormal_chest_morphology0.86088609
91MP0002736_abnormal_nociception_after0.85687509
92MP0003638_abnormal_response/metabolism_0.84573750
93MP0002419_abnormal_innate_immunity0.81357907
94MP0005389_reproductive_system_phenotype0.81165418
95MP0002693_abnormal_pancreas_physiology0.80041902
96MP0009643_abnormal_urine_homeostasis0.79763869
97MP0009333_abnormal_splenocyte_physiolog0.77069976
98MP0003137_abnormal_impulse_conducting0.76942352
99MP0001440_abnormal_grooming_behavior0.74121231
100MP0000383_abnormal_hair_follicle0.72964425
101MP0001666_abnormal_nutrient_absorption0.72720223
102MP0002429_abnormal_blood_cell0.71760917
103MP0001533_abnormal_skeleton_physiology0.70155520
104MP0001188_hyperpigmentation0.69182437
105MP0003252_abnormal_bile_duct0.68858576
106MP0002095_abnormal_skin_pigmentation0.67650966
107MP0001968_abnormal_touch/_nociception0.65023974
108MP0002572_abnormal_emotion/affect_behav0.62546890
109MP0008004_abnormal_stomach_pH0.62024996
110MP0008007_abnormal_cellular_replicative0.61532316
111MP0002234_abnormal_pharynx_morphology0.61088778
112MP0000358_abnormal_cell_content/0.59272282
113MP0005551_abnormal_eye_electrophysiolog0.59056170
114MP0003635_abnormal_synaptic_transmissio0.58693570
115MP0008872_abnormal_physiological_respon0.58193333
116MP0009745_abnormal_behavioral_response0.57924375
117MP0002928_abnormal_bile_duct0.55377110
118MP0003633_abnormal_nervous_system0.52865012
119MP0004270_analgesia0.52798573
120MP0005423_abnormal_somatic_nervous0.52649351
121MP0002971_abnormal_brown_adipose0.52434761
122MP0002064_seizures0.51174754
123MP0001486_abnormal_startle_reflex0.50188301
124MP0005253_abnormal_eye_physiology0.49289322
125MP0004036_abnormal_muscle_relaxation0.49153861
126MP0000604_amyloidosis0.49067806
127MP0003631_nervous_system_phenotype0.46381692
128MP0002063_abnormal_learning/memory/cond0.46247302
129MP0005636_abnormal_mineral_homeostasis0.45516225
130MP0004811_abnormal_neuron_physiology0.44522565
131MP0003786_premature_aging0.44407416
132MP0008995_early_reproductive_senescence0.44141347
133MP0002152_abnormal_brain_morphology0.43662336
134MP0000427_abnormal_hair_cycle0.43282520
135MP0003950_abnormal_plasma_membrane0.42794400
136MP0002102_abnormal_ear_morphology0.41619473
137MP0002272_abnormal_nervous_system0.38877501
138MP0004859_abnormal_synaptic_plasticity0.38794845
139MP0004019_abnormal_vitamin_homeostasis0.38576796
140MP0003861_abnormal_nervous_system0.38400201
141MP0003699_abnormal_female_reproductive0.38028063
142MP0004133_heterotaxia0.36857764
143MP0001324_abnormal_eye_pigmentation0.35932771
144MP0004808_abnormal_hematopoietic_stem0.34539867
145MP0001986_abnormal_taste_sensitivity0.34317565
146MP0003880_abnormal_central_pattern0.32507653
147MP0006036_abnormal_mitochondrial_physio0.32432414
148MP0002229_neurodegeneration0.32279883
149MP0003115_abnormal_respiratory_system0.31654863
150MP0005535_abnormal_body_temperature0.31152318
151MP0000778_abnormal_nervous_system0.31047417
152MP0004145_abnormal_muscle_electrophysio0.30171772
153MP0006138_congestive_heart_failure0.29789451
154MP0008875_abnormal_xenobiotic_pharmacok0.29762151
155MP0004742_abnormal_vestibular_system0.28813276
156MP0002067_abnormal_sensory_capabilities0.28812348
157MP0001293_anophthalmia0.28242366
158MP0000462_abnormal_digestive_system0.28070222
159MP0005391_vision/eye_phenotype0.27716670
160MP0002557_abnormal_social/conspecific_i0.27538110
161MP0010307_abnormal_tumor_latency0.26680682
162MP0005397_hematopoietic_system_phenotyp0.26446517
163MP0001545_abnormal_hematopoietic_system0.26446517
164MP0002269_muscular_atrophy0.26434478
165MP0000751_myopathy0.26018799
166MP0003879_abnormal_hair_cell0.25277083
167MP0003948_abnormal_gas_homeostasis0.24676313
168MP0002066_abnormal_motor_capabilities/c0.24556524
169MP0001119_abnormal_female_reproductive0.24181563
170MP0006035_abnormal_mitochondrial_morpho0.24136973
171MP0006072_abnormal_retinal_apoptosis0.23076711
172MP0002882_abnormal_neuron_morphology0.22737457
173MP0000955_abnormal_spinal_cord0.22291770
174MP0000920_abnormal_myelination0.21978521
175MP0000569_abnormal_digit_pigmentation0.21959564
176MP0002734_abnormal_mechanical_nocicepti0.21742582
177MP0008569_lethality_at_weaning0.21578521

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.75467818
2Abnormal respiratory motile cilium morphology (HP:0005938)8.42167638
3Abnormal respiratory epithelium morphology (HP:0012253)8.42167638
4Rhinitis (HP:0012384)8.20704699
5Abnormal ciliary motility (HP:0012262)7.99631521
6Chronic bronchitis (HP:0004469)7.43415538
7Nasal polyposis (HP:0100582)6.63209751
8Infertility (HP:0000789)6.03337003
9Abnormality of the nasal mucosa (HP:0000433)5.43092855
10IgG deficiency (HP:0004315)5.19087745
11Bronchitis (HP:0012387)4.74249159
12Bronchiectasis (HP:0002110)4.73300067
13Nephronophthisis (HP:0000090)4.59505364
14Severe combined immunodeficiency (HP:0004430)4.37795005
15Elevated erythrocyte sedimentation rate (HP:0003565)3.95006472
16Thyroiditis (HP:0100646)3.88534839
17Congenital stationary night blindness (HP:0007642)3.77547926
18Aplastic anemia (HP:0001915)3.73761332
19Prostate neoplasm (HP:0100787)3.72741333
20T lymphocytopenia (HP:0005403)3.71558191
21Stomach cancer (HP:0012126)3.61100271
22Abnormality of T cell number (HP:0011839)3.59385074
23Abnormality of the renal medulla (HP:0100957)3.48244689
24Recurrent otitis media (HP:0000403)3.45683076
25Recurrent sinusitis (HP:0011108)3.43898923
26Pancreatic cysts (HP:0001737)3.40044010
27Combined immunodeficiency (HP:0005387)3.24366764
28Abnormality of eosinophils (HP:0001879)3.21547076
29Abnormality of the lower motor neuron (HP:0002366)3.19303755
30Hypoproteinemia (HP:0003075)3.10256033
31Aplasia/Hypoplasia of the tibia (HP:0005772)3.08931564
32Neonatal respiratory distress (HP:0002643)3.06449524
33Renal cortical cysts (HP:0000803)3.03239093
34Recurrent bronchitis (HP:0002837)2.94804906
35Clumsiness (HP:0002312)2.92033541
36Gaze-evoked nystagmus (HP:0000640)2.89545164
37Genetic anticipation (HP:0003743)2.77056098
38Abnormality of the prostate (HP:0008775)2.74744873
39Abnormality of midbrain morphology (HP:0002418)2.73818538
40Molar tooth sign on MRI (HP:0002419)2.73818538
41Amelogenesis imperfecta (HP:0000705)2.73412588
42Attenuation of retinal blood vessels (HP:0007843)2.73126219
43Tubulointerstitial nephritis (HP:0001970)2.72672985
44Gonadotropin excess (HP:0000837)2.72487673
45Abolished electroretinogram (ERG) (HP:0000550)2.71451732
46Abnormality of T cells (HP:0002843)2.70980621
47Autoimmune thrombocytopenia (HP:0001973)2.69210116
48Male infertility (HP:0003251)2.68677153
49Medial flaring of the eyebrow (HP:0010747)2.68269612
50Abnormal spermatogenesis (HP:0008669)2.65120963
51Hypoalbuminemia (HP:0003073)2.63919395
52Abnormal albumin level (HP:0012116)2.63919395
53Cerebral palsy (HP:0100021)2.61816887
54Fibular hypoplasia (HP:0003038)2.57311334
55Increased IgM level (HP:0003496)2.57218210
56Tubular atrophy (HP:0000092)2.54386380
57Amyotrophic lateral sclerosis (HP:0007354)2.54291731
58Autoimmune hemolytic anemia (HP:0001890)2.53996815
59Progressive cerebellar ataxia (HP:0002073)2.44237318
60Tubulointerstitial abnormality (HP:0001969)2.42277854
61Congenital, generalized hypertrichosis (HP:0004540)2.38535277
62Eosinophilia (HP:0001880)2.36641388
63Oligomenorrhea (HP:0000876)2.35356887
64J-shaped sella turcica (HP:0002680)2.34215250
65IgM deficiency (HP:0002850)2.33638283
66Stomatitis (HP:0010280)2.30819238
67Postaxial foot polydactyly (HP:0001830)2.30818437
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30022840
69Short tibia (HP:0005736)2.29816436
70Abnormality of B cell number (HP:0010975)2.24263893
71Microglossia (HP:0000171)2.23227042
72Hypoplasia of the pons (HP:0012110)2.21763515
733-Methylglutaconic aciduria (HP:0003535)2.17296497
74Hepatocellular necrosis (HP:0001404)2.15513089
75Abnormality of the pons (HP:0007361)2.14023209
76Type I transferrin isoform profile (HP:0003642)2.12725289
77Azoospermia (HP:0000027)2.11965815
78Ketosis (HP:0001946)2.11879330
79Absent frontal sinuses (HP:0002688)2.10785192
80Thick nail (HP:0001805)2.10415505
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09585590
82Conical tooth (HP:0000698)2.07174663
83Congenital hepatic fibrosis (HP:0002612)2.07015940
84Urethral obstruction (HP:0000796)2.05945687
85Broad-based gait (HP:0002136)2.04990567
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04524089
87Abnormality of the neuromuscular junction (HP:0003398)2.04462809
88Fatigable weakness (HP:0003473)2.04462809
89Metabolic alkalosis (HP:0200114)2.03816941
90Hypoplasia of the ulna (HP:0003022)2.03741199
91Tubulointerstitial fibrosis (HP:0005576)2.01952245
92Leukocytosis (HP:0001974)2.00632728
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.6977648
94Dynein arm defect of respiratory motile cilia (HP:0012255)11.9067572
95Absent/shortened dynein arms (HP:0200106)11.9067572
96Chronic sinusitis (HP:0011109)1.98688107
97Impulsivity (HP:0100710)1.98565386
98Alopecia of scalp (HP:0002293)1.98408033
99Macular degeneration (HP:0000608)1.93263248
100Renal dysplasia (HP:0000110)1.91929129
101Impaired proprioception (HP:0010831)1.91850124
102Hyperventilation (HP:0002883)1.91621005
103Chronic diarrhea (HP:0002028)1.91145095
104Facial cleft (HP:0002006)1.90094618
105Stage 5 chronic kidney disease (HP:0003774)1.89308597
106Short ribs (HP:0000773)1.88571591
107Hyperalaninemia (HP:0003348)1.88299541
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88299541
109Abnormality of alanine metabolism (HP:0010916)1.88299541
110Large for gestational age (HP:0001520)1.86709265
111Hypoplasia of the uterus (HP:0000013)1.85941220
112Hepatic necrosis (HP:0002605)1.85808946
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85631733
114Abnormal protein N-linked glycosylation (HP:0012347)1.85631733
115Abnormal protein glycosylation (HP:0012346)1.85631733
116Abnormal glycosylation (HP:0012345)1.85631733
117Median cleft lip (HP:0000161)1.84975944
118Chronic hepatic failure (HP:0100626)1.84971138
119Pancytopenia (HP:0001876)1.84389369
120Upper motor neuron abnormality (HP:0002127)1.84299117
121Decreased circulating renin level (HP:0003351)1.83981953
122Pancreatic fibrosis (HP:0100732)1.81336694
123Abnormality of the axillary hair (HP:0100134)1.80275878
124Abnormality of secondary sexual hair (HP:0009888)1.80275878
125Pustule (HP:0200039)1.79979142
126Encephalitis (HP:0002383)1.79662714
127Pulmonary infiltrates (HP:0002113)1.79033449
128Abnormality of the renal cortex (HP:0011035)1.78531077
129Aplasia/Hypoplasia of the ulna (HP:0006495)1.76900659
130Mitochondrial inheritance (HP:0001427)1.76710861
131Abnormal rod and cone electroretinograms (HP:0008323)1.75384544
132Abnormality of T cell physiology (HP:0011840)1.74661670
133Abnormal drinking behavior (HP:0030082)1.74296167
134Polydipsia (HP:0001959)1.74296167
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73704174
136Oculomotor apraxia (HP:0000657)1.72409229
137Abnormality of permanent molar morphology (HP:0011071)1.69113252
138Abnormality of the dental root (HP:0006486)1.69113252
139Taurodontia (HP:0000679)1.69113252
140Postaxial hand polydactyly (HP:0001162)1.67025694
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.66206381
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64525573
143Absent epiphyses (HP:0010577)1.64525573
144Gait imbalance (HP:0002141)1.63651143
145Congenital primary aphakia (HP:0007707)1.62362243
146Abnormality of molar (HP:0011077)1.60943739
147Abnormality of molar morphology (HP:0011070)1.60943739
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.60526355
14911 pairs of ribs (HP:0000878)1.59252732
150Spastic tetraparesis (HP:0001285)1.56840929
151Abnormality of ocular smooth pursuit (HP:0000617)1.55938182
152Abnormality of dentin (HP:0010299)1.54533374
153Deformed sella turcica (HP:0002681)1.54488395
154Abnormality of the dental pulp (HP:0006479)1.51811526
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51399674
156Abnormality of renal excretion (HP:0011036)1.48490296
157Pachygyria (HP:0001302)1.46826312
158Supernumerary spleens (HP:0009799)1.46533681
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45688663
160Short thorax (HP:0010306)1.45468079
161Abnormal gallbladder physiology (HP:0012438)1.44584874
162Cholecystitis (HP:0001082)1.44584874
163Abnormality of the anterior horn cell (HP:0006802)1.41512109
164Degeneration of anterior horn cells (HP:0002398)1.41512109
165Cystic liver disease (HP:0006706)1.39727239
166Abnormal biliary tract physiology (HP:0012439)1.38914090
167Bile duct proliferation (HP:0001408)1.38914090
168Nephrogenic diabetes insipidus (HP:0009806)1.38763352
169Decreased central vision (HP:0007663)1.38444018
170Retinal dysplasia (HP:0007973)1.37018048
171Breast carcinoma (HP:0003002)1.35354027
172Bell-shaped thorax (HP:0001591)1.33570713
173Neurofibrillary tangles (HP:0002185)1.32369767
174Type II lissencephaly (HP:0007260)1.31292169
175Genital tract atresia (HP:0001827)1.30736348
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29849410
177Cerebellar dysplasia (HP:0007033)1.29415610
178Nephropathy (HP:0000112)1.28413950
179Aplasia/Hypoplasia of the lens (HP:0008063)1.28328449
180Heterotopia (HP:0002282)1.28236505
181Abnormality of saccadic eye movements (HP:0000570)1.24141689
182Large eyes (HP:0001090)1.20641189
183True hermaphroditism (HP:0010459)1.20612126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.69327788
2PDK48.69327788
3PDK25.59880777
4TESK14.35351413
5TAOK33.83588739
6KDR3.79724408
7FRK3.79362948
8TXK3.56559392
9PRKD33.50013530
10STK393.19506841
11WNK43.11102024
12AKT32.93619266
13PTK2B2.77423225
14PNCK2.66608308
15ICK2.53527787
16MYLK2.28822791
17MAP4K22.21563666
18BCKDK2.18439335
19TLK12.12715181
20EPHA32.12364622
21LIMK11.78620119
22GRK61.75458659
23MAPKAPK31.72472671
24NEK21.71909444
25ADRBK21.66680861
26STK381.58344277
27GRK11.56298076
28ITK1.51537941
29ZAK1.45002985
30MAP4K11.28932992
31MAP3K121.28231307
32RIPK41.22554393
33NUAK11.20841015
34TNK21.19084151
35WNK11.16248924
36INSRR1.15311568
37TRPM71.13933816
38CCNB11.08292812
39IKBKB1.07522430
40MAP2K21.05685895
41BTK1.05339767
42WEE11.04501737
43TEC1.03606540
44MAPK151.02418664
45IKBKE0.95522004
46PASK0.94480688
47BMPR1B0.91877562
48PDK10.90916665
49MAP2K70.89803274
50LCK0.88945048
51TYRO30.87445466
52SYK0.86964007
53DAPK10.86535134
54RPS6KA50.84658077
55JAK10.84334997
56STK30.82487300
57LMTK20.81672005
58DYRK1B0.78782705
59MAP3K110.78525431
60TTK0.76494531
61MAPK130.76468971
62IRAK10.73604837
63CDK190.71623331
64DAPK20.70779362
65MAP3K40.69824111
66OBSCN0.69551670
67ERBB30.67676835
68GRK70.67345217
69ACVR1B0.65852706
70MAP3K90.64500697
71CSF1R0.63869280
72FES0.62728897
73DYRK30.62634743
74CHUK0.62460226
75CSNK1A1L0.59599839
76CDC70.59470348
77TBK10.59078823
78MAP3K140.58715680
79STK38L0.57565461
80SGK4940.57094028
81SGK2230.57094028
82CAMKK20.55989249
83NTRK30.55617627
84MAPK110.55433063
85IGF1R0.54258534
86VRK10.53960815
87SGK20.52952500
88PINK10.52616853
89NLK0.52038903
90ADRBK10.49344375
91KIT0.49270283
92SCYL20.48616208
93ATR0.48419794
94NTRK20.47122651
95VRK20.47107485
96PDPK10.45816577
97EPHB10.45805297
98ROCK10.45691829
99CHEK20.44906426
100CHEK10.42636674
101LYN0.40748344
102HCK0.40173804
103LATS10.39436550
104BRSK20.38865388
105PRKCG0.38648838
106ERBB20.38568570
107MAPKAPK50.37201819
108NME10.36168330
109TNIK0.35867103
110CSNK1G30.35398442
111CSK0.35044887
112RPS6KA40.34833279
113INSR0.34594435
114MAPKAPK20.34278547
115PRKCE0.34061450
116EIF2AK30.30806255
117PIM10.30260469
118ATM0.29932972
119PRKAA20.29837195
120MST40.29003257
121MUSK0.28729452
122TESK20.28408302
123BRSK10.28130088
124CSNK1G10.26738446
125PLK10.26002639
126CAMK1G0.24484979
127ZAP700.23462028
128PIK3CA0.23254669
129PRKCQ0.22144903
130EEF2K0.21940936
131PAK10.21684811
132OXSR10.21189802
133MAP2K40.21039913
134CAMKK10.20304685
135BMPR20.19500075
136IRAK20.18857993
137STK110.18091380
138PDGFRB0.16959335
139BRAF0.15577097
140CDK150.14396030
141CDK30.14287593
142MAP2K60.14239826
143CDK50.13758490
144RPS6KB10.13549042
145MINK10.13020738
146PRKG10.12798141
147CDK180.12581441
148MTOR0.11924858
149CAMK2A0.10695482
150CDK11A0.10677550
151PRKAA10.10353198
152MARK10.10092540
153WNK30.09841623
154NEK60.09792688
155MAPK100.09641127
156STK160.08300795
157MARK20.07830724
158CDK140.07761042
159PRKCZ0.07272483
160PRKD20.06856813
161PRKACG0.06640457
162CDK10.06624441
163PRKCB0.04566720
164PRKDC0.04408989
165GSK3B0.04342058
166PAK20.03953271
167CSNK2A20.03884728
168CSNK2A10.03747830
169MAPK80.03368488
170PRKACA0.03119215
171EGFR0.02815791
172PRKACB0.02544138
173YES10.02359233
174CDK20.01625747
175PAK60.01158852
176EPHA40.01125933
177PRKCA0.01002296

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.64494866
2Primary immunodeficiency_Homo sapiens_hsa053404.55606486
3Pyruvate metabolism_Homo sapiens_hsa006203.75786196
4Pentose phosphate pathway_Homo sapiens_hsa000303.52451017
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.44821463
6Graft-versus-host disease_Homo sapiens_hsa053323.26673338
7Propanoate metabolism_Homo sapiens_hsa006403.03895330
8Huntingtons disease_Homo sapiens_hsa050162.78984335
9Dorso-ventral axis formation_Homo sapiens_hsa043202.73910026
10Glucagon signaling pathway_Homo sapiens_hsa049222.73535933
11Autoimmune thyroid disease_Homo sapiens_hsa053202.67487558
12Allograft rejection_Homo sapiens_hsa053302.65765408
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.62649655
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.57958497
15Basal transcription factors_Homo sapiens_hsa030222.40396529
16Fatty acid biosynthesis_Homo sapiens_hsa000612.34654913
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31387806
18Fanconi anemia pathway_Homo sapiens_hsa034602.27844257
19Linoleic acid metabolism_Homo sapiens_hsa005912.25859554
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22236452
21Amphetamine addiction_Homo sapiens_hsa050312.20509478
22Phototransduction_Homo sapiens_hsa047442.17805185
23Oocyte meiosis_Homo sapiens_hsa041142.14952291
24Type I diabetes mellitus_Homo sapiens_hsa049402.13328986
25Asthma_Homo sapiens_hsa053102.12481020
26Proteasome_Homo sapiens_hsa030502.09283675
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94464970
28Butanoate metabolism_Homo sapiens_hsa006501.93686791
29Selenocompound metabolism_Homo sapiens_hsa004501.88849712
30Renin secretion_Homo sapiens_hsa049241.83779383
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82207789
32Hematopoietic cell lineage_Homo sapiens_hsa046401.80693441
33Glycerolipid metabolism_Homo sapiens_hsa005611.79994127
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76411974
35RNA polymerase_Homo sapiens_hsa030201.74719947
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.70435622
37T cell receptor signaling pathway_Homo sapiens_hsa046601.69635093
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54663524
39Long-term potentiation_Homo sapiens_hsa047201.54325546
40Cardiac muscle contraction_Homo sapiens_hsa042601.53408150
41Carbon metabolism_Homo sapiens_hsa012001.47738146
42Nitrogen metabolism_Homo sapiens_hsa009101.47626849
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.38159155
44Tryptophan metabolism_Homo sapiens_hsa003801.36937091
45Rheumatoid arthritis_Homo sapiens_hsa053231.33309090
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32277456
47PPAR signaling pathway_Homo sapiens_hsa033201.31503417
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.30818872
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30228254
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26931094
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.26236790
52Biosynthesis of amino acids_Homo sapiens_hsa012301.26180025
53Caffeine metabolism_Homo sapiens_hsa002321.23195989
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20916691
55Viral myocarditis_Homo sapiens_hsa054161.18897710
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18227063
57Ether lipid metabolism_Homo sapiens_hsa005651.17713393
58Retinol metabolism_Homo sapiens_hsa008301.16459934
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13182802
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.07676780
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07046261
62beta-Alanine metabolism_Homo sapiens_hsa004101.06665693
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.05466818
64Fat digestion and absorption_Homo sapiens_hsa049751.03322764
65Nicotine addiction_Homo sapiens_hsa050331.03014278
66Fructose and mannose metabolism_Homo sapiens_hsa000511.00551010
67Calcium signaling pathway_Homo sapiens_hsa040200.98303077
68mRNA surveillance pathway_Homo sapiens_hsa030150.96439324
69Peroxisome_Homo sapiens_hsa041460.95599429
70Taste transduction_Homo sapiens_hsa047420.95442574
71Purine metabolism_Homo sapiens_hsa002300.93449812
72RNA transport_Homo sapiens_hsa030130.93238716
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91399526
74Renin-angiotensin system_Homo sapiens_hsa046140.91346553
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90682436
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90495706
77ABC transporters_Homo sapiens_hsa020100.89904288
78Systemic lupus erythematosus_Homo sapiens_hsa053220.88836272
79Regulation of autophagy_Homo sapiens_hsa041400.88400112
80Glutamatergic synapse_Homo sapiens_hsa047240.88041797
81Mineral absorption_Homo sapiens_hsa049780.84634316
82Circadian entrainment_Homo sapiens_hsa047130.83124486
83Circadian rhythm_Homo sapiens_hsa047100.82818204
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81426776
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80264260
86Shigellosis_Homo sapiens_hsa051310.79277403
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77357844
88Alzheimers disease_Homo sapiens_hsa050100.76178628
89Olfactory transduction_Homo sapiens_hsa047400.75891801
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75875556
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75811461
92Collecting duct acid secretion_Homo sapiens_hsa049660.74178522
93Ovarian steroidogenesis_Homo sapiens_hsa049130.73508001
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72952038
95Synaptic vesicle cycle_Homo sapiens_hsa047210.72883393
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72583306
97Estrogen signaling pathway_Homo sapiens_hsa049150.72164486
98Protein export_Homo sapiens_hsa030600.72141612
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70983031
100Oxidative phosphorylation_Homo sapiens_hsa001900.70056885
101Fatty acid metabolism_Homo sapiens_hsa012120.69555049
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69390330
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68287718
104Insulin secretion_Homo sapiens_hsa049110.67911007
105Measles_Homo sapiens_hsa051620.67744308
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65200338
107Gastric acid secretion_Homo sapiens_hsa049710.63869808
108Fatty acid degradation_Homo sapiens_hsa000710.63798627
109Herpes simplex infection_Homo sapiens_hsa051680.62062684
110Glutathione metabolism_Homo sapiens_hsa004800.61849507
111Salivary secretion_Homo sapiens_hsa049700.61470800
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60681987
113Histidine metabolism_Homo sapiens_hsa003400.59715566
114Malaria_Homo sapiens_hsa051440.59133964
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57577439
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57569712
117Morphine addiction_Homo sapiens_hsa050320.57283703
118Sulfur metabolism_Homo sapiens_hsa009200.56904526
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56168368
120Serotonergic synapse_Homo sapiens_hsa047260.56140517
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55304820
122Chemical carcinogenesis_Homo sapiens_hsa052040.55026061
123Dopaminergic synapse_Homo sapiens_hsa047280.52836531
124Alcoholism_Homo sapiens_hsa050340.52471532
125Pyrimidine metabolism_Homo sapiens_hsa002400.52414238
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49693163
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49374599
128Cocaine addiction_Homo sapiens_hsa050300.47841663
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47400709
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47173535
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46513094
132AMPK signaling pathway_Homo sapiens_hsa041520.46425880
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45899748
134Parkinsons disease_Homo sapiens_hsa050120.45747909
135Lysine degradation_Homo sapiens_hsa003100.45329382
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.44682612
137Inositol phosphate metabolism_Homo sapiens_hsa005620.44649870
138Thyroid hormone synthesis_Homo sapiens_hsa049180.44120506
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44052042
140Arachidonic acid metabolism_Homo sapiens_hsa005900.43202590
141Homologous recombination_Homo sapiens_hsa034400.43042522
142Metabolic pathways_Homo sapiens_hsa011000.42993013
143GABAergic synapse_Homo sapiens_hsa047270.42455246
144VEGF signaling pathway_Homo sapiens_hsa043700.42016523
145Phenylalanine metabolism_Homo sapiens_hsa003600.40497534
146Pancreatic secretion_Homo sapiens_hsa049720.40082215
147RNA degradation_Homo sapiens_hsa030180.37070243
148Antigen processing and presentation_Homo sapiens_hsa046120.35313218
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35193576
150Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34626130
151Endocytosis_Homo sapiens_hsa041440.34122768
152Bile secretion_Homo sapiens_hsa049760.34012787
153Salmonella infection_Homo sapiens_hsa051320.31853044
154Staphylococcus aureus infection_Homo sapiens_hsa051500.30898160
155cAMP signaling pathway_Homo sapiens_hsa040240.30267761
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30074770
157Oxytocin signaling pathway_Homo sapiens_hsa049210.27917668
158Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27862441
159TNF signaling pathway_Homo sapiens_hsa046680.27715508
160Vitamin digestion and absorption_Homo sapiens_hsa049770.27619220
161Tyrosine metabolism_Homo sapiens_hsa003500.27451170
162Central carbon metabolism in cancer_Homo sapiens_hsa052300.27202101
163Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26086055
164N-Glycan biosynthesis_Homo sapiens_hsa005100.22636818

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