POTEF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.52442933
2regulation of RNA export from nucleus (GO:0046831)4.48662293
3hemidesmosome assembly (GO:0031581)4.42826561
4nuclear pore organization (GO:0006999)4.20169640
5RNA localization (GO:0006403)4.16783562
6mitotic sister chromatid cohesion (GO:0007064)4.13807601
7regulation of centriole replication (GO:0046599)4.12122457
8sister chromatid cohesion (GO:0007062)3.91174631
9establishment of protein localization to Golgi (GO:0072600)3.56919203
10spliceosomal tri-snRNP complex assembly (GO:0000244)3.55548764
11regulation of hippo signaling (GO:0035330)3.50466296
12embryonic foregut morphogenesis (GO:0048617)3.44022374
13regulation of nucleobase-containing compound transport (GO:0032239)3.39622317
14non-recombinational repair (GO:0000726)3.37333002
15double-strand break repair via nonhomologous end joining (GO:0006303)3.37333002
16protein targeting to Golgi (GO:0000042)3.33851488
17regulation of centrosome cycle (GO:0046605)3.33637550
18binding of sperm to zona pellucida (GO:0007339)3.31664326
19limb bud formation (GO:0060174)3.28083463
20metaphase plate congression (GO:0051310)3.27586795
21sister chromatid segregation (GO:0000819)3.20806726
22DNA double-strand break processing (GO:0000729)3.19389581
23pore complex assembly (GO:0046931)3.18925422
24regulation of centrosome duplication (GO:0010824)3.18860379
25sperm-egg recognition (GO:0035036)3.13832687
26retrograde transport, vesicle recycling within Golgi (GO:0000301)3.11484370
27mitotic sister chromatid segregation (GO:0000070)3.10972601
28pre-miRNA processing (GO:0031054)3.08726051
29centriole replication (GO:0007099)3.08234860
30regulation of mitotic spindle checkpoint (GO:1903504)3.05182083
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05182083
32regulation of DNA endoreduplication (GO:0032875)3.03901892
33DNA strand renaturation (GO:0000733)2.97582090
34DNA replication checkpoint (GO:0000076)2.94968418
35histone H2A acetylation (GO:0043968)2.94539309
36resolution of meiotic recombination intermediates (GO:0000712)2.89909393
37sperm motility (GO:0030317)2.86646843
38lung lobe morphogenesis (GO:0060463)2.84399534
39replication fork processing (GO:0031297)2.83246514
40negative regulation of DNA-dependent DNA replication (GO:2000104)2.82576184
41chromosome condensation (GO:0030261)2.80797431
42histone exchange (GO:0043486)2.78716021
43double-strand break repair via homologous recombination (GO:0000724)2.72881531
44* retina homeostasis (GO:0001895)2.72040055
45synapsis (GO:0007129)2.71910422
46rRNA methylation (GO:0031167)2.71897566
47recombinational repair (GO:0000725)2.69970226
48protein localization to Golgi apparatus (GO:0034067)2.69579698
49ectoderm development (GO:0007398)2.69325328
50ribosome assembly (GO:0042255)2.67334309
51mitotic metaphase plate congression (GO:0007080)2.67172816
52DNA packaging (GO:0006323)2.64806963
53mitotic nuclear envelope disassembly (GO:0007077)2.64227630
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62231641
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.62231641
56regulation of translation, ncRNA-mediated (GO:0045974)2.62231641
57multicellular organism reproduction (GO:0032504)2.62193469
58microtubule anchoring (GO:0034453)2.61791805
59motile cilium assembly (GO:0044458)2.52873108
60cell-cell recognition (GO:0009988)2.51905293
61protein localization to kinetochore (GO:0034501)2.51538216
62artery development (GO:0060840)2.50374630
63centriole assembly (GO:0098534)2.50147960
64intra-Golgi vesicle-mediated transport (GO:0006891)2.49994707
65mesenchymal cell proliferation (GO:0010463)2.49370125
66mRNA cleavage (GO:0006379)2.48519460
67mitotic cytokinesis (GO:0000281)2.48173074
68double-strand break repair (GO:0006302)2.46564532
69genitalia morphogenesis (GO:0035112)2.45912782
70DNA geometric change (GO:0032392)2.44749896
71somite development (GO:0061053)2.42952832
72nuclear envelope disassembly (GO:0051081)2.41616403
73membrane disassembly (GO:0030397)2.41616403
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.41219741
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41219741
76negative regulation of smooth muscle cell differentiation (GO:0051151)2.41192812
77meiotic chromosome segregation (GO:0045132)2.41160846
78spindle checkpoint (GO:0031577)2.40735001
79single strand break repair (GO:0000012)2.38541553
80NLS-bearing protein import into nucleus (GO:0006607)2.37945981
81DNA conformation change (GO:0071103)2.37936962
82microtubule depolymerization (GO:0007019)2.37592176
83DNA duplex unwinding (GO:0032508)2.37480362
84intra-S DNA damage checkpoint (GO:0031573)2.35790246
85mitotic spindle checkpoint (GO:0071174)2.35340252
86ncRNA catabolic process (GO:0034661)2.35211351
87DNA replication-dependent nucleosome assembly (GO:0006335)2.34255916
88DNA replication-dependent nucleosome organization (GO:0034723)2.34255916
89tRNA aminoacylation for protein translation (GO:0006418)2.33194677
90DNA integration (GO:0015074)2.33028049
91microtubule polymerization or depolymerization (GO:0031109)2.31775914
92monoubiquitinated protein deubiquitination (GO:0035520)2.31223043
93amino acid activation (GO:0043038)2.30321558
94tRNA aminoacylation (GO:0043039)2.30321558
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.29222794
96kinetochore assembly (GO:0051382)2.27899795
97positive regulation of glycolytic process (GO:0045821)2.27791590
98snRNA processing (GO:0016180)2.27259187
99lung epithelium development (GO:0060428)2.26788014
100chromatin remodeling at centromere (GO:0031055)2.25820362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.61733083
2ZNF274_21170338_ChIP-Seq_K562_Hela3.21276964
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17490590
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08170285
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.92611466
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88533919
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57342904
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52519238
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38878723
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.35498895
11FUS_26573619_Chip-Seq_HEK293_Human2.28646545
12AR_21909140_ChIP-Seq_LNCAP_Human2.26983465
13EWS_26573619_Chip-Seq_HEK293_Human2.18075945
14IGF1R_20145208_ChIP-Seq_DFB_Human2.14457031
15VDR_22108803_ChIP-Seq_LS180_Human1.99873788
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98748641
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97836768
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.94733499
19TAF15_26573619_Chip-Seq_HEK293_Human1.93851157
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93825060
21ELK1_19687146_ChIP-ChIP_HELA_Human1.89463729
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.86786977
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85912900
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83823544
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80887850
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79432485
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78113627
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75695217
29GBX2_23144817_ChIP-Seq_PC3_Human1.73019118
30ER_23166858_ChIP-Seq_MCF-7_Human1.72446621
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71854075
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.70879306
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68264477
34P300_19829295_ChIP-Seq_ESCs_Human1.66574543
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.58148559
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58011553
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.57000032
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54374778
39SMAD4_21799915_ChIP-Seq_A2780_Human1.52277305
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51326248
41VDR_23849224_ChIP-Seq_CD4+_Human1.50090557
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48850494
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47476265
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.45561564
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43664518
46TCF4_23295773_ChIP-Seq_U87_Human1.42594662
47STAT3_23295773_ChIP-Seq_U87_Human1.42588086
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39388582
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39092274
50CBP_20019798_ChIP-Seq_JUKART_Human1.39092274
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38580185
52BCAT_22108803_ChIP-Seq_LS180_Human1.36650399
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34397689
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34397689
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29279555
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.28364393
57TCF4_22108803_ChIP-Seq_LS180_Human1.28363125
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26124747
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23593618
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.22699271
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22405757
62AHR_22903824_ChIP-Seq_MCF-7_Human1.20714446
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19755548
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.19622381
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18576023
66FOXP3_21729870_ChIP-Seq_TREG_Human1.17912870
67IRF1_19129219_ChIP-ChIP_H3396_Human1.17755134
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17709739
69DCP1A_22483619_ChIP-Seq_HELA_Human1.17646178
70RUNX2_22187159_ChIP-Seq_PCA_Human1.17423790
71MYC_18940864_ChIP-ChIP_HL60_Human1.14925242
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12414530
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10708638
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.08954901
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.07867006
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05855656
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05585624
78AR_21572438_ChIP-Seq_LNCaP_Human1.05485653
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04443702
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04123220
81CDX2_22108803_ChIP-Seq_LS180_Human1.03406380
82GABP_19822575_ChIP-Seq_HepG2_Human1.03115601
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02861673
84TP53_22573176_ChIP-Seq_HFKS_Human1.02473465
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02142684
86AR_25329375_ChIP-Seq_VCAP_Human1.01689013
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01083677
88SOX2_19829295_ChIP-Seq_ESCs_Human1.00448459
89NANOG_19829295_ChIP-Seq_ESCs_Human1.00448459
90KDM5A_27292631_Chip-Seq_BREAST_Human0.99621742
91TP53_16413492_ChIP-PET_HCT116_Human0.99605208
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97546633
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95033932
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94045581
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89685035
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89185794
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88680791
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88396303
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87904438
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86640946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.26158705
2MP0008057_abnormal_DNA_replication3.13663649
3MP0010094_abnormal_chromosome_stability2.91472538
4MP0008058_abnormal_DNA_repair2.65410479
5MP0009697_abnormal_copulation2.29920895
6MP0004957_abnormal_blastocyst_morpholog2.25909412
7MP0003937_abnormal_limbs/digits/tail_de2.23940296
8MP0001299_abnormal_eye_distance/2.19214035
9MP0005410_abnormal_fertilization2.15564271
10MP0003111_abnormal_nucleus_morphology2.07568704
11MP0002234_abnormal_pharynx_morphology2.06902343
12MP0003077_abnormal_cell_cycle1.99819002
13MP0003718_maternal_effect1.92787748
14MP0010030_abnormal_orbit_morphology1.92735366
15MP0003890_abnormal_embryonic-extraembry1.83223045
16MP0006035_abnormal_mitochondrial_morpho1.80146754
17MP0003693_abnormal_embryo_hatching1.77304533
18MP0002233_abnormal_nose_morphology1.69438582
19MP0001293_anophthalmia1.68890826
20MP0000383_abnormal_hair_follicle1.59765960
21MP0002938_white_spotting1.54966009
22MP0002697_abnormal_eye_size1.52989838
23MP0008932_abnormal_embryonic_tissue1.47940589
24MP0002282_abnormal_trachea_morphology1.44745585
25MP0010307_abnormal_tumor_latency1.41983935
26MP0002269_muscular_atrophy1.41620017
27MP0005187_abnormal_penis_morphology1.41152519
28MP0003136_yellow_coat_color1.39513816
29MP0001929_abnormal_gametogenesis1.39187977
30MP0003938_abnormal_ear_development1.38511022
31MP0000569_abnormal_digit_pigmentation1.37325997
32MP0008995_early_reproductive_senescence1.35690015
33MP0009780_abnormal_chondrocyte_physiolo1.35604885
34MP0010678_abnormal_skin_adnexa1.33697375
35MP0002084_abnormal_developmental_patter1.31457795
36MP0003119_abnormal_digestive_system1.29735121
37MP0000751_myopathy1.29466432
38MP0003941_abnormal_skin_development1.29262386
39MP0002111_abnormal_tail_morphology1.27887280
40MP0003315_abnormal_perineum_morphology1.27349996
41MP0003984_embryonic_growth_retardation1.27048930
42MP0001672_abnormal_embryogenesis/_devel1.26217227
43MP0005380_embryogenesis_phenotype1.26217227
44MP0002088_abnormal_embryonic_growth/wei1.25934790
45MP0003698_abnormal_male_reproductive1.25707281
46MP0003045_fibrosis1.25203654
47MP0000537_abnormal_urethra_morphology1.23961521
48MP0000358_abnormal_cell_content/1.19355216
49MP0001286_abnormal_eye_development1.18600402
50MP0001346_abnormal_lacrimal_gland1.18060323
51MP0002160_abnormal_reproductive_system1.16177338
52MP0005395_other_phenotype1.15550999
53MP0005551_abnormal_eye_electrophysiolog1.13604082
54MP0003935_abnormal_craniofacial_develop1.12990203
55MP0010352_gastrointestinal_tract_polyps1.11820238
56MP0004197_abnormal_fetal_growth/weight/1.11143976
57MP0002085_abnormal_embryonic_tissue1.08062558
58MP0001529_abnormal_vocalization1.06335963
59MP0003755_abnormal_palate_morphology1.05617474
60MP0001666_abnormal_nutrient_absorption1.03625594
61MP0001697_abnormal_embryo_size1.03596118
62MP0002736_abnormal_nociception_after1.03376681
63MP0000631_abnormal_neuroendocrine_gland1.00434109
64MP0003283_abnormal_digestive_organ1.00344796
65MP0001730_embryonic_growth_arrest0.98681146
66MP0002210_abnormal_sex_determination0.97800532
67MP0003385_abnormal_body_wall0.96652644
68MP0009703_decreased_birth_body0.95734925
69MP0009053_abnormal_anal_canal0.95423944
70MP0003950_abnormal_plasma_membrane0.93743174
71MP0005408_hypopigmentation0.93174304
72MP0002332_abnormal_exercise_endurance0.90499158
73MP0001661_extended_life_span0.90492556
74MP0000749_muscle_degeneration0.89724485
75MP0008877_abnormal_DNA_methylation0.89519612
76MP0000428_abnormal_craniofacial_morphol0.88421809
77MP0000647_abnormal_sebaceous_gland0.87094686
78MP0005248_abnormal_Harderian_gland0.86983774
79MP0005646_abnormal_pituitary_gland0.86692526
80MP0002080_prenatal_lethality0.86547743
81MP0003943_abnormal_hepatobiliary_system0.86429920
82MP0000653_abnormal_sex_gland0.84516608
83MP0004272_abnormal_basement_membrane0.84336943
84MP0003195_calcinosis0.84081173
85MP0002796_impaired_skin_barrier0.83976157
86MP0005266_abnormal_metabolism0.82950816
87MP0002751_abnormal_autonomic_nervous0.82481425
88MP0003122_maternal_imprinting0.82019531
89MP0001145_abnormal_male_reproductive0.79343289
90MP0000432_abnormal_head_morphology0.78994657
91MP0001984_abnormal_olfaction0.78531612
92MP0006292_abnormal_olfactory_placode0.78433520
93MP0002086_abnormal_extraembryonic_tissu0.75742892
94MP0000613_abnormal_salivary_gland0.75034385
95MP0003936_abnormal_reproductive_system0.74376925
96MP0002161_abnormal_fertility/fecundity0.73440497
97MP0002168_other_aberrant_phenotype0.73385861
98MP0003861_abnormal_nervous_system0.72496366
99MP0002109_abnormal_limb_morphology0.72242135
100MP0000566_synostosis0.71500813

Predicted human phenotypes

RankGene SetZ-score
1Urethral obstruction (HP:0000796)6.18052351
2Neonatal respiratory distress (HP:0002643)4.44501119
3Alopecia of scalp (HP:0002293)3.98298044
4Volvulus (HP:0002580)3.90170154
5Increased connective tissue (HP:0009025)3.30311291
6Alacrima (HP:0000522)3.23217211
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91706927
8Decreased lacrimation (HP:0000633)2.86059085
9Chromsome breakage (HP:0040012)2.72263046
10Thick nail (HP:0001805)2.69510330
11Bifid tongue (HP:0010297)2.68095278
12Bilateral microphthalmos (HP:0007633)2.61515204
13Oligomenorrhea (HP:0000876)2.61265404
14Abnormality of the ileum (HP:0001549)2.58046791
15Short chin (HP:0000331)2.56818121
16Abnormality of the astrocytes (HP:0100707)2.48521090
17Astrocytoma (HP:0009592)2.48521090
18Ependymoma (HP:0002888)2.47876142
19Glioma (HP:0009733)2.46946293
20Intestinal atresia (HP:0011100)2.45532591
21Meckel diverticulum (HP:0002245)2.45058287
22Tubulointerstitial nephritis (HP:0001970)2.41467321
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.40742409
24Abnormality of the neuromuscular junction (HP:0003398)2.40335676
25Fatigable weakness (HP:0003473)2.40335676
26Anal stenosis (HP:0002025)2.38421493
27Cerebellar dysplasia (HP:0007033)2.38171523
28Abnormality of chromosome stability (HP:0003220)2.29773204
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.29296353
30Abnormality of the preputium (HP:0100587)2.28729405
31Sloping forehead (HP:0000340)2.27483447
32Abnormality of the lower motor neuron (HP:0002366)2.25314561
33Small intestinal stenosis (HP:0012848)2.20311353
34Duodenal stenosis (HP:0100867)2.20311353
35Abnormality of the duodenum (HP:0002246)2.13897530
36Increased nuchal translucency (HP:0010880)2.13343455
37Difficulty climbing stairs (HP:0003551)2.12851037
38Abnormality of the parathyroid morphology (HP:0011766)2.11567266
39Anophthalmia (HP:0000528)2.10064044
40Absent radius (HP:0003974)2.09798852
41Abnormal tarsal ossification (HP:0008369)2.07997799
42Pancreatic cysts (HP:0001737)2.05828745
43Hand muscle atrophy (HP:0009130)2.05649806
44Chronic hepatic failure (HP:0100626)2.02382873
45Pancreatic islet-cell hyperplasia (HP:0004510)2.01815303
46Ectopic kidney (HP:0000086)2.01056470
47True hermaphroditism (HP:0010459)1.99450443
48Abnormality of the labia minora (HP:0012880)1.98400757
49Triphalangeal thumb (HP:0001199)1.95493881
50Aplasia involving forearm bones (HP:0009822)1.95421854
51Absent forearm bone (HP:0003953)1.95421854
52Partial duplication of thumb phalanx (HP:0009944)1.95288577
53Duplication of thumb phalanx (HP:0009942)1.93916536
54Short 1st metacarpal (HP:0010034)1.92636965
55Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92636965
56Abnormal number of incisors (HP:0011064)1.92079140
57Microtia (HP:0008551)1.92047524
58Limited hip movement (HP:0008800)1.91386113
59Abnormal foot bone ossification (HP:0010675)1.90205681
60Underdeveloped nasal alae (HP:0000430)1.90130170
61Cupped ear (HP:0000378)1.89923891
62Thyroid-stimulating hormone excess (HP:0002925)1.89276414
63Abnormality of midbrain morphology (HP:0002418)1.89234634
64Molar tooth sign on MRI (HP:0002419)1.89234634
65Oligodactyly (hands) (HP:0001180)1.87707577
66Abnormality of methionine metabolism (HP:0010901)1.87524697
67Rhabdomyosarcoma (HP:0002859)1.87388527
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85843974
69Pancreatic fibrosis (HP:0100732)1.85651340
70Abnormality of the renal medulla (HP:0100957)1.84195587
71Abnormality of the nasal septum (HP:0000419)1.83245267
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.81114396
73Enlarged kidneys (HP:0000105)1.80765300
74Short tibia (HP:0005736)1.80420955
75Short thumb (HP:0009778)1.78721075
76Proximal tubulopathy (HP:0000114)1.78237636
77Nephronophthisis (HP:0000090)1.78225551
78Preaxial hand polydactyly (HP:0001177)1.76448496
79Milia (HP:0001056)1.74301497
80Limited elbow extension (HP:0001377)1.71490796
81Aqueductal stenosis (HP:0002410)1.69898937
82Renal hypoplasia (HP:0000089)1.69794546
83Renal cortical cysts (HP:0000803)1.69621126
84Abnormality of the carotid arteries (HP:0005344)1.68260884
85Distal upper limb amyotrophy (HP:0007149)1.68053606
86Upper limb amyotrophy (HP:0009129)1.68053606
87Small hand (HP:0200055)1.66926196
88Proximal placement of thumb (HP:0009623)1.65083598
89Abnormality of the 1st metacarpal (HP:0010009)1.63245691
90Midline defect of the nose (HP:0004122)1.63222805
91Supernumerary spleens (HP:0009799)1.62866878
92Abnormal lung lobation (HP:0002101)1.62733553
93High anterior hairline (HP:0009890)1.62081775
94Abnormality of the renal cortex (HP:0011035)1.60996372
95Myelomeningocele (HP:0002475)1.60758145
96Postaxial foot polydactyly (HP:0001830)1.58941724
97Clubbing of toes (HP:0100760)1.58849699
98Embryonal renal neoplasm (HP:0011794)1.58207969
99Palmar hyperkeratosis (HP:0010765)1.56739945
100Hypobetalipoproteinemia (HP:0003563)1.55643343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.11901352
2ZAK2.97044297
3EIF2AK12.63474614
4LATS12.53859744
5AKT32.48902013
6PLK42.47663098
7PBK2.41287939
8BRD42.30217983
9CDK122.25962297
10TSSK62.24958454
11TRIM282.12486016
12EIF2AK32.09259156
13CASK2.08682505
14NUAK12.01756966
15WNK41.89956404
16TLK11.89530292
17NEK11.82868886
18BRSK21.81393549
19MAP4K21.81286211
20BCR1.80192250
21MAP3K41.78536271
22NEK21.76446711
23STK391.75125145
24BUB11.65741642
25WNK31.57937226
26MKNK21.46265380
27TTK1.44118043
28ACVR1B1.40133731
29PLK11.37821966
30PINK11.34601947
31PKN21.32962112
32BMPR1B1.32699460
33AURKB1.28855951
34STK38L1.28342881
35ATR1.26953544
36OXSR11.23415019
37MKNK11.20855045
38FGFR21.18594332
39CAMK1D1.16697384
40ATM1.16477005
41CAMK1G1.12306224
42FGFR11.11376948
43STK31.09696205
44CDC71.06677998
45PLK31.04347419
46CHEK21.04318559
47ERBB30.98875176
48SRPK10.98450246
49PDK20.98336144
50CHEK10.97389394
51OBSCN0.95590881
52WEE10.92739282
53MAP3K120.87894740
54ICK0.83898946
55FLT30.79920274
56EIF2AK20.79665586
57PNCK0.79112765
58CDK10.74662123
59TNIK0.73973397
60CSNK1E0.73791046
61CSNK1A1L0.72713504
62VRK10.71024580
63EPHA20.70546522
64INSRR0.69773306
65MAP2K70.67493547
66NTRK30.66809464
67BRSK10.66670819
68CSNK1G10.64813045
69RPS6KA50.64174368
70CLK10.62494483
71MST40.62493137
72CDK20.61255787
73AURKA0.61059851
74NEK60.61057089
75CDK30.60353797
76STK380.60062637
77FER0.58158623
78MELK0.56924601
79SGK20.55955629
80BMPR20.55872098
81ERBB20.55399232
82MTOR0.53769627
83PRKDC0.52850821
84CCNB10.51852898
85SCYL20.50634936
86PRKACB0.50277452
87GRK10.50148302
88MET0.49044538
89ERBB40.48071736
90CSNK2A20.47872808
91CDK70.46584717
92FGFR40.46564962
93NME10.45859442
94PRKAA10.44709493
95GSK3B0.43565901
96MAPK140.38874760
97ROCK10.36246971
98PRKAA20.35527258
99PRKCE0.34451475
100AKT20.33645888

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.34198653
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09098098
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69095241
4RNA transport_Homo sapiens_hsa030132.53747914
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52967279
6Fanconi anemia pathway_Homo sapiens_hsa034602.46394650
7Basal transcription factors_Homo sapiens_hsa030222.43192425
8One carbon pool by folate_Homo sapiens_hsa006702.41465738
9Mismatch repair_Homo sapiens_hsa034302.36792613
10Homologous recombination_Homo sapiens_hsa034402.34481573
11Butanoate metabolism_Homo sapiens_hsa006502.20919739
12Propanoate metabolism_Homo sapiens_hsa006402.20063296
13RNA polymerase_Homo sapiens_hsa030202.01146903
14DNA replication_Homo sapiens_hsa030301.96188712
15Spliceosome_Homo sapiens_hsa030401.92485089
16Lysine degradation_Homo sapiens_hsa003101.89574071
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87390216
18Steroid biosynthesis_Homo sapiens_hsa001001.73615662
19Nitrogen metabolism_Homo sapiens_hsa009101.64394064
20Proteasome_Homo sapiens_hsa030501.63423562
21Systemic lupus erythematosus_Homo sapiens_hsa053221.58557618
22RNA degradation_Homo sapiens_hsa030181.57490441
23Nucleotide excision repair_Homo sapiens_hsa034201.52347795
24mRNA surveillance pathway_Homo sapiens_hsa030151.46640068
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.39233808
26Cell cycle_Homo sapiens_hsa041101.39231454
27Fatty acid biosynthesis_Homo sapiens_hsa000611.33083220
28Alcoholism_Homo sapiens_hsa050341.30702531
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28376885
30Fatty acid metabolism_Homo sapiens_hsa012121.17969185
31Protein export_Homo sapiens_hsa030601.17208658
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17010431
33Olfactory transduction_Homo sapiens_hsa047401.16342091
34Arginine biosynthesis_Homo sapiens_hsa002201.16173843
35TGF-beta signaling pathway_Homo sapiens_hsa043501.15998200
36Pyrimidine metabolism_Homo sapiens_hsa002401.13265987
37Tryptophan metabolism_Homo sapiens_hsa003801.12653086
38N-Glycan biosynthesis_Homo sapiens_hsa005101.09011644
39Hedgehog signaling pathway_Homo sapiens_hsa043401.08613721
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06578040
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04530004
42Purine metabolism_Homo sapiens_hsa002301.03982932
43Taste transduction_Homo sapiens_hsa047421.02468947
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00865372
45Hippo signaling pathway_Homo sapiens_hsa043901.00261216
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99129836
47Adherens junction_Homo sapiens_hsa045200.99004095
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98022750
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96447344
50Vitamin digestion and absorption_Homo sapiens_hsa049770.95367601
51Tight junction_Homo sapiens_hsa045300.94057399
52Arginine and proline metabolism_Homo sapiens_hsa003300.92948193
53Pyruvate metabolism_Homo sapiens_hsa006200.91563343
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90848076
55Vitamin B6 metabolism_Homo sapiens_hsa007500.88881137
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86109199
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84851835
58Fatty acid degradation_Homo sapiens_hsa000710.82141841
59Glutathione metabolism_Homo sapiens_hsa004800.81896246
60Fatty acid elongation_Homo sapiens_hsa000620.80337967
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79618313
62Phototransduction_Homo sapiens_hsa047440.77852906
63Basal cell carcinoma_Homo sapiens_hsa052170.75689123
64Circadian rhythm_Homo sapiens_hsa047100.75350325
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.75047639
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74492938
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73467791
68Fat digestion and absorption_Homo sapiens_hsa049750.73450857
69Base excision repair_Homo sapiens_hsa034100.71480164
70beta-Alanine metabolism_Homo sapiens_hsa004100.70600472
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69239835
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66916477
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66308956
74Carbon metabolism_Homo sapiens_hsa012000.66269525
75Biosynthesis of amino acids_Homo sapiens_hsa012300.65722616
76p53 signaling pathway_Homo sapiens_hsa041150.65595715
77Oocyte meiosis_Homo sapiens_hsa041140.65363765
78Peroxisome_Homo sapiens_hsa041460.64084277
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63904387
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62472716
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60491938
82ABC transporters_Homo sapiens_hsa020100.60045289
83Chemical carcinogenesis_Homo sapiens_hsa052040.59813234
84Metabolic pathways_Homo sapiens_hsa011000.52688891
85Retinol metabolism_Homo sapiens_hsa008300.50849692
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50309566
87Selenocompound metabolism_Homo sapiens_hsa004500.49832384
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48056328
89Caffeine metabolism_Homo sapiens_hsa002320.44998663
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44586029
91Histidine metabolism_Homo sapiens_hsa003400.44049802
92Wnt signaling pathway_Homo sapiens_hsa043100.41814016
93Viral carcinogenesis_Homo sapiens_hsa052030.40802004
94Phenylalanine metabolism_Homo sapiens_hsa003600.40549428
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40539736
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38758079
97Tyrosine metabolism_Homo sapiens_hsa003500.36587450
98Glycerolipid metabolism_Homo sapiens_hsa005610.36466329
99ECM-receptor interaction_Homo sapiens_hsa045120.36291450
100Nicotine addiction_Homo sapiens_hsa050330.35825507

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