POTEE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)5.17831285
2regulation of centriole replication (GO:0046599)4.79620431
3resolution of meiotic recombination intermediates (GO:0000712)4.61131335
4maturation of SSU-rRNA (GO:0030490)4.50736540
5centriole assembly (GO:0098534)4.24765139
6DNA replication checkpoint (GO:0000076)4.07884978
7behavioral response to nicotine (GO:0035095)4.01512999
8ribosomal small subunit assembly (GO:0000028)3.91021332
9detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.88297189
10microtubule depolymerization (GO:0007019)3.87158151
11replication fork processing (GO:0031297)3.77653112
12rRNA modification (GO:0000154)3.60580915
13sensory perception of smell (GO:0007608)3.57968656
14sperm motility (GO:0030317)3.53396739
15negative regulation of transcription regulatory region DNA binding (GO:2000678)3.53329547
16multicellular organism reproduction (GO:0032504)3.49406548
17meiotic chromosome segregation (GO:0045132)3.47543956
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37305851
19ATP synthesis coupled proton transport (GO:0015986)3.36278075
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36278075
21synapsis (GO:0007129)3.33342683
22ribosomal small subunit biogenesis (GO:0042274)3.30125531
23regulation of centrosome cycle (GO:0046605)3.25682160
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22757940
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.22757940
26NADH dehydrogenase complex assembly (GO:0010257)3.22757940
27rRNA catabolic process (GO:0016075)3.22625951
28regulation of mitotic spindle checkpoint (GO:1903504)3.21162026
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21162026
30nonmotile primary cilium assembly (GO:0035058)3.16086279
31rRNA methylation (GO:0031167)3.11127707
32ribosomal large subunit biogenesis (GO:0042273)3.09738932
33kinetochore assembly (GO:0051382)3.07469802
34establishment of protein localization to Golgi (GO:0072600)3.06691110
35kinetochore organization (GO:0051383)3.04227285
36sperm-egg recognition (GO:0035036)3.01915578
37regulation of centrosome duplication (GO:0010824)3.01551393
38double-strand break repair via homologous recombination (GO:0000724)3.01496056
39recombinational repair (GO:0000725)2.99079039
40microtubule polymerization or depolymerization (GO:0031109)2.97738196
41detection of chemical stimulus involved in sensory perception (GO:0050907)2.93879359
42ribonucleoprotein complex biogenesis (GO:0022613)2.93839041
43telomere maintenance via telomerase (GO:0007004)2.92808674
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90244566
45histone exchange (GO:0043486)2.90242986
46pseudouridine synthesis (GO:0001522)2.89211573
47motile cilium assembly (GO:0044458)2.87877112
48regulation of cilium movement (GO:0003352)2.87166960
49DNA methylation involved in gamete generation (GO:0043046)2.81390328
50ribosome biogenesis (GO:0042254)2.79694365
51translational termination (GO:0006415)2.79483916
52protein complex biogenesis (GO:0070271)2.76115725
53cellular component biogenesis (GO:0044085)2.75895142
54water-soluble vitamin biosynthetic process (GO:0042364)2.74143971
55viral transcription (GO:0019083)2.73525586
56fusion of sperm to egg plasma membrane (GO:0007342)2.73086127
57nuclear pore complex assembly (GO:0051292)2.72769644
58protein-cofactor linkage (GO:0018065)2.72666750
59chromatin remodeling at centromere (GO:0031055)2.72019820
60spliceosomal complex assembly (GO:0000245)2.72016428
61cilium movement (GO:0003341)2.69566725
62centrosome duplication (GO:0051298)2.69279524
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68724794
64mitochondrial respiratory chain complex assembly (GO:0033108)2.68531793
65telomere maintenance via semi-conservative replication (GO:0032201)2.65495806
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64839664
67CENP-A containing nucleosome assembly (GO:0034080)2.64757096
68regulation of female receptivity (GO:0045924)2.63704797
69ubiquinone biosynthetic process (GO:0006744)2.63420557
70acrosome reaction (GO:0007340)2.60757451
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59690576
72terpenoid biosynthetic process (GO:0016114)2.59200764
73DNA strand elongation involved in DNA replication (GO:0006271)2.58792024
74centrosome organization (GO:0051297)2.57790281
75protein targeting to Golgi (GO:0000042)2.56383474
76adaptation of signaling pathway (GO:0023058)2.55352110
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55314202
78male meiosis I (GO:0007141)2.54878814
79DNA damage response, detection of DNA damage (GO:0042769)2.53127155
80respiratory chain complex IV assembly (GO:0008535)2.52531679
81male meiosis (GO:0007140)2.51384425
82regulation of DNA endoreduplication (GO:0032875)2.50968186
83spermatid development (GO:0007286)2.50145863
84reciprocal meiotic recombination (GO:0007131)2.49852925
85reciprocal DNA recombination (GO:0035825)2.49852925
86microtubule organizing center organization (GO:0031023)2.49236434
87ATP biosynthetic process (GO:0006754)2.49088606
88regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.48038878
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.46889753
90diterpenoid biosynthetic process (GO:0016102)2.46800034
91DNA packaging (GO:0006323)2.46035254
92sister chromatid segregation (GO:0000819)2.44683127
93ubiquinone metabolic process (GO:0006743)2.44559973
94DNA strand elongation (GO:0022616)2.44243293
95indolalkylamine metabolic process (GO:0006586)2.43182137
96tRNA aminoacylation for protein translation (GO:0006418)2.42416472
97peptidyl-histidine modification (GO:0018202)2.41377144
98nephron tubule morphogenesis (GO:0072078)2.41271477
99nephron epithelium morphogenesis (GO:0072088)2.41271477
100amino acid activation (GO:0043038)2.41255844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24625437
2E2F7_22180533_ChIP-Seq_HELA_Human3.57429180
3VDR_22108803_ChIP-Seq_LS180_Human3.54062154
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45046503
5ZNF274_21170338_ChIP-Seq_K562_Hela3.26179079
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.13873654
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87753294
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72056821
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.66972523
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54589554
11EWS_26573619_Chip-Seq_HEK293_Human2.25736560
12ELK1_19687146_ChIP-ChIP_HELA_Human2.24078260
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.22581951
14VDR_23849224_ChIP-Seq_CD4+_Human1.97996672
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97238699
16FUS_26573619_Chip-Seq_HEK293_Human1.96721497
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89327781
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85321850
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85015908
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83609717
21IRF1_19129219_ChIP-ChIP_H3396_Human1.83186373
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79591347
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.77336153
24ER_23166858_ChIP-Seq_MCF-7_Human1.76488401
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67909757
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.66851105
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65607025
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65056094
29TAF15_26573619_Chip-Seq_HEK293_Human1.60001646
30IGF1R_20145208_ChIP-Seq_DFB_Human1.59291343
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58498629
32P300_19829295_ChIP-Seq_ESCs_Human1.52864837
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.47789590
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43974851
35FOXP3_21729870_ChIP-Seq_TREG_Human1.40741571
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.40656016
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40373584
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39271347
39TP53_22573176_ChIP-Seq_HFKS_Human1.38494037
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37682397
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36480865
42CBP_20019798_ChIP-Seq_JUKART_Human1.35154137
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35154137
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33146708
45GBX2_23144817_ChIP-Seq_PC3_Human1.32512767
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31130155
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30104838
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30104838
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.29045376
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28510264
51MYC_18940864_ChIP-ChIP_HL60_Human1.26627751
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22429807
53TTF2_22483619_ChIP-Seq_HELA_Human1.21499551
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20961714
55GABP_19822575_ChIP-Seq_HepG2_Human1.20307252
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19901858
57* TCF4_23295773_ChIP-Seq_U87_Human1.19609345
58SOX2_19829295_ChIP-Seq_ESCs_Human1.17080029
59NANOG_19829295_ChIP-Seq_ESCs_Human1.17080029
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.16065149
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.14152455
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13934642
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13710606
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12738509
65STAT3_23295773_ChIP-Seq_U87_Human1.10727548
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10164538
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.08555478
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08555478
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08303730
70RBPJ_21746931_ChIP-Seq_IB4_Human1.07072822
71* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06620528
72HOXB7_26014856_ChIP-Seq_BT474_Human1.06310483
73* NCOR_22424771_ChIP-Seq_293T_Human1.06098197
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.05374919
75* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03696146
76ETV1_20927104_ChIP-Seq_GIST48_Human1.02497211
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02020682
78PHF8_20622853_ChIP-Seq_HELA_Human1.01399882
79TCF4_22108803_ChIP-Seq_LS180_Human1.01339149
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00682379
81JUN_21703547_ChIP-Seq_K562_Human1.00162641
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99049082
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98480264
84RUNX2_22187159_ChIP-Seq_PCA_Human0.97439467
85SMAD4_21799915_ChIP-Seq_A2780_Human0.97408449
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96197668
87AR_21572438_ChIP-Seq_LNCaP_Human0.95289080
88AR_25329375_ChIP-Seq_VCAP_Human0.94432385
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94302794
90MYC_19829295_ChIP-Seq_ESCs_Human0.94066255
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94026259
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93634905
93KDM5A_27292631_Chip-Seq_BREAST_Human0.93271506
94ERA_21632823_ChIP-Seq_H3396_Human0.92892671
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91644269
96P53_21459846_ChIP-Seq_SAOS-2_Human0.90658516
97DCP1A_22483619_ChIP-Seq_HELA_Human0.90534569
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90373653
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89711096
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88604560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.43306557
2MP0003136_yellow_coat_color2.70807613
3MP0005410_abnormal_fertilization2.53282842
4MP0008789_abnormal_olfactory_epithelium2.38038474
5MP0004147_increased_porphyrin_level2.30408000
6MP0008058_abnormal_DNA_repair2.28771434
7MP0003718_maternal_effect2.22770809
8MP0002102_abnormal_ear_morphology2.15276044
9MP0001529_abnormal_vocalization2.06582717
10MP0006276_abnormal_autonomic_nervous2.05096051
11MP0006072_abnormal_retinal_apoptosis1.99143525
12MP0010094_abnormal_chromosome_stability1.99111382
13MP0002736_abnormal_nociception_after1.95895679
14MP0000372_irregular_coat_pigmentation1.95606352
15MP0004145_abnormal_muscle_electrophysio1.94471626
16MP0009697_abnormal_copulation1.88305904
17MP0008877_abnormal_DNA_methylation1.85208271
18MP0008995_early_reproductive_senescence1.84166958
19MP0002132_abnormal_respiratory_system1.80227932
20MP0004957_abnormal_blastocyst_morpholog1.80050539
21MP0005646_abnormal_pituitary_gland1.78317969
22MP0005499_abnormal_olfactory_system1.78145697
23MP0005394_taste/olfaction_phenotype1.78145697
24MP0001293_anophthalmia1.75860200
25MP0001929_abnormal_gametogenesis1.75439935
26MP0003646_muscle_fatigue1.74394506
27MP0008872_abnormal_physiological_respon1.70343372
28MP0002160_abnormal_reproductive_system1.67083179
29MP0001968_abnormal_touch/_nociception1.64558743
30MP0002210_abnormal_sex_determination1.64441950
31MP0003693_abnormal_embryo_hatching1.60682420
32MP0002938_white_spotting1.60072848
33MP0004885_abnormal_endolymph1.59680242
34MP0003698_abnormal_male_reproductive1.56676298
35MP0004142_abnormal_muscle_tone1.54529872
36MP0002234_abnormal_pharynx_morphology1.52346514
37MP0003111_abnormal_nucleus_morphology1.50368594
38MP0005551_abnormal_eye_electrophysiolog1.50282633
39MP0003937_abnormal_limbs/digits/tail_de1.40136853
40MP0006035_abnormal_mitochondrial_morpho1.37659744
41MP0000631_abnormal_neuroendocrine_gland1.37221330
42MP0003123_paternal_imprinting1.33982798
43MP0003077_abnormal_cell_cycle1.32033089
44MP0006036_abnormal_mitochondrial_physio1.30662459
45MP0003121_genomic_imprinting1.30351151
46MP0005389_reproductive_system_phenotype1.24689862
47MP0005253_abnormal_eye_physiology1.22372192
48MP0003122_maternal_imprinting1.22271699
49MP0008057_abnormal_DNA_replication1.21061025
50MP0003938_abnormal_ear_development1.20033893
51MP0008775_abnormal_heart_ventricle1.18461404
52MP0008932_abnormal_embryonic_tissue1.17960582
53MP0000653_abnormal_sex_gland1.14705960
54MP0004043_abnormal_pH_regulation1.14683292
55MP0001145_abnormal_male_reproductive1.12618877
56MP0005360_urolithiasis1.12588197
57MP0005636_abnormal_mineral_homeostasis1.08721803
58MP0001919_abnormal_reproductive_system1.08429645
59MP0002272_abnormal_nervous_system1.07158732
60MP0005083_abnormal_biliary_tract1.06790168
61MP0002653_abnormal_ependyma_morphology1.05553729
62MP0001485_abnormal_pinna_reflex1.03155625
63MP0000647_abnormal_sebaceous_gland1.02706746
64MP0003878_abnormal_ear_physiology1.02110520
65MP0005377_hearing/vestibular/ear_phenot1.02110520
66MP0005408_hypopigmentation1.00162711
67MP0003786_premature_aging1.00053563
68MP0000427_abnormal_hair_cycle0.99628863
69MP0003787_abnormal_imprinting0.97394004
70MP0002233_abnormal_nose_morphology0.96347459
71MP0001984_abnormal_olfaction0.95456349
72MP0001486_abnormal_startle_reflex0.94824738
73MP0002161_abnormal_fertility/fecundity0.94589880
74MP0003942_abnormal_urinary_system0.92166138
75MP0002095_abnormal_skin_pigmentation0.91986820
76MP0004742_abnormal_vestibular_system0.90656316
77MP0003315_abnormal_perineum_morphology0.90288481
78MP0003890_abnormal_embryonic-extraembry0.90233500
79MP0009379_abnormal_foot_pigmentation0.88830071
80MP0002163_abnormal_gland_morphology0.88408612
81MP0000049_abnormal_middle_ear0.88183357
82MP0001286_abnormal_eye_development0.86929688
83MP0005187_abnormal_penis_morphology0.86749603
84MP0003119_abnormal_digestive_system0.86390946
85MP0009046_muscle_twitch0.86170201
86MP0002184_abnormal_innervation0.85845484
87MP0004085_abnormal_heartbeat0.85631993
88MP0001661_extended_life_span0.84881745
89MP0002735_abnormal_chemical_nociception0.82134950
90MP0005391_vision/eye_phenotype0.82124906
91MP0002733_abnormal_thermal_nociception0.80761499
92MP0002557_abnormal_social/conspecific_i0.80258348
93MP0002282_abnormal_trachea_morphology0.80171126
94MP0008007_abnormal_cellular_replicative0.79210739
95MP0003385_abnormal_body_wall0.78982230
96MP0001119_abnormal_female_reproductive0.76924478
97MP0005395_other_phenotype0.74758014
98MP0009780_abnormal_chondrocyte_physiolo0.73963150
99MP0000358_abnormal_cell_content/0.72176982
100MP0002752_abnormal_somatic_nervous0.71725946

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.85590186
2Pancreatic cysts (HP:0001737)3.33775182
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22647344
4Abnormality of midbrain morphology (HP:0002418)3.19787965
5Molar tooth sign on MRI (HP:0002419)3.19787965
6Abnormality of the labia minora (HP:0012880)3.18024774
7Nephronophthisis (HP:0000090)3.17595470
8Chromsome breakage (HP:0040012)3.14726605
9Abnormal ciliary motility (HP:0012262)3.11004811
10Acute necrotizing encephalopathy (HP:0006965)3.05925417
11Acute encephalopathy (HP:0006846)2.88921635
12Abnormality of the renal cortex (HP:0011035)2.83275017
13Tubular atrophy (HP:0000092)2.78441156
14Abnormality of cells of the erythroid lineage (HP:0012130)2.76932805
15Pancreatic fibrosis (HP:0100732)2.75598233
16Abnormality of reticulocytes (HP:0004312)2.73809712
17True hermaphroditism (HP:0010459)2.71560980
18Abnormality of the renal medulla (HP:0100957)2.68765294
19Pallor (HP:0000980)2.67238030
20Duodenal stenosis (HP:0100867)2.65370715
21Small intestinal stenosis (HP:0012848)2.65370715
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.63820901
23Abnormal mitochondria in muscle tissue (HP:0008316)2.62798760
24Abnormal respiratory motile cilium physiology (HP:0012261)2.58338712
25Increased CSF lactate (HP:0002490)2.57743232
26Macrocytic anemia (HP:0001972)2.55990280
27Short middle phalanx of the 5th finger (HP:0004220)2.53853813
28Acanthocytosis (HP:0001927)2.53106525
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.52506571
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49556157
31Abnormality of alanine metabolism (HP:0010916)2.49556157
32Hyperalaninemia (HP:0003348)2.49556157
33Meckel diverticulum (HP:0002245)2.48680398
34Abnormality of the renal collecting system (HP:0004742)2.44784820
35Mitochondrial inheritance (HP:0001427)2.44277837
36Horseshoe kidney (HP:0000085)2.43029836
37Hyperthyroidism (HP:0000836)2.42951616
38Duplicated collecting system (HP:0000081)2.41931444
39Progressive macrocephaly (HP:0004481)2.41011755
40Abnormality of DNA repair (HP:0003254)2.40886184
41Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.39765788
42Birth length less than 3rd percentile (HP:0003561)2.39377215
43Abnormality of the ileum (HP:0001549)2.39043904
44Tubulointerstitial nephritis (HP:0001970)2.38821983
45Concave nail (HP:0001598)2.38279054
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.38169190
47Chronic hepatic failure (HP:0100626)2.35805654
48Abnormal respiratory epithelium morphology (HP:0012253)2.34915498
49Abnormal respiratory motile cilium morphology (HP:0005938)2.34915498
50Ectopic kidney (HP:0000086)2.34089614
51Abnormal number of erythroid precursors (HP:0012131)2.31590547
52Medial flaring of the eyebrow (HP:0010747)2.31476783
53Abnormality of chromosome stability (HP:0003220)2.29606548
54Hepatocellular necrosis (HP:0001404)2.26416492
55Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.24100576
56Abnormality of the duodenum (HP:0002246)2.21775157
57Reticulocytosis (HP:0001923)2.20861066
58Cerebellar dysplasia (HP:0007033)2.20808899
59Abnormality of the preputium (HP:0100587)2.18685779
60Abnormality of cochlea (HP:0000375)2.15848802
61Poikilocytosis (HP:0004447)2.15013653
62Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13675768
63Impulsivity (HP:0100710)2.09632662
64Absent/shortened dynein arms (HP:0200106)2.07793959
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.07793959
66Abnormality of homocysteine metabolism (HP:0010919)2.05411741
67Homocystinuria (HP:0002156)2.05411741
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04826562
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.03600879
70Increased serum lactate (HP:0002151)2.02111080
71Absent thumb (HP:0009777)2.01879882
72Type II lissencephaly (HP:0007260)2.01681834
73Hepatic necrosis (HP:0002605)2.01543819
74Sloping forehead (HP:0000340)2.00667540
75Hypoplastic iliac wings (HP:0002866)2.00441665
76Truncus arteriosus (HP:0001660)1.98430588
77Abnormal rod and cone electroretinograms (HP:0008323)1.98239294
78Sclerocornea (HP:0000647)1.97652916
79Increased hepatocellular lipid droplets (HP:0006565)1.94870369
80Triphalangeal thumb (HP:0001199)1.90991650
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88262638
82Cerebral edema (HP:0002181)1.87382809
83Methylmalonic acidemia (HP:0002912)1.84770109
84Anencephaly (HP:0002323)1.84264318
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.83613296
86Clubbing of toes (HP:0100760)1.82372154
87Hyperglycinemia (HP:0002154)1.77893259
88Aganglionic megacolon (HP:0002251)1.77573856
89Morphological abnormality of the inner ear (HP:0011390)1.77550823
90Lipid accumulation in hepatocytes (HP:0006561)1.76776990
91Bony spicule pigmentary retinopathy (HP:0007737)1.75874032
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.74984873
93Abnormality of the carotid arteries (HP:0005344)1.74250272
94Optic disc pallor (HP:0000543)1.69229722
95Hypoplasia of the pons (HP:0012110)1.68777453
96Cystic liver disease (HP:0006706)1.68400170
97Patellar aplasia (HP:0006443)1.68265821
98Depressed nasal ridge (HP:0000457)1.67143186
99Aplasia/Hypoplasia of the patella (HP:0006498)1.65781863
100Postaxial foot polydactyly (HP:0001830)1.63735706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.14424507
2WNK43.58681697
3EIF2AK13.28386619
4TRIM283.02967368
5MAP3K42.82401392
6WNK32.56658635
7TAOK32.44037730
8NUAK12.36205735
9FRK2.29800382
10AKT32.21682363
11CDC71.98026343
12MKNK21.82792114
13PDK21.80698439
14PINK11.75815887
15MAP4K21.75710358
16BUB11.70519720
17PBK1.63258517
18BMPR21.62126908
19NTRK31.60924643
20NEK21.55891592
21STK391.53651794
22ADRBK21.49657953
23ZAK1.47347687
24LATS11.44343214
25CDK81.42231849
26BMPR1B1.38818082
27MAP2K71.24752742
28MAPK131.23844993
29PLK21.23721668
30TTK1.23127722
31BRSK21.19510458
32TNIK1.18755500
33MAP2K21.16029455
34OBSCN1.13828064
35NEK11.12213520
36SRPK11.10527265
37GRK11.10369232
38NME11.10075020
39MKNK11.07735772
40CCNB11.05784367
41INSRR1.04818852
42PIK3CG1.02560177
43WNK11.02112821
44PLK11.01912563
45CHEK20.99478097
46PLK30.91840298
47BRSK10.91337408
48STK160.91023375
49CDK120.90349695
50BRD40.90154796
51CLK10.85941403
52OXSR10.84464557
53ATR0.84208088
54PTK2B0.84150344
55MST40.83092499
56WEE10.81780874
57DYRK20.81693523
58EIF2AK30.79558291
59TXK0.75968492
60AURKB0.75307259
61VRK10.72548179
62ATM0.72353651
63TLK10.68210488
64MAP2K10.66018712
65CHEK10.65279973
66TSSK60.61784154
67RIPK40.60285338
68ERBB30.58485281
69CDK10.58071976
70CSNK1E0.57812673
71MUSK0.57792562
72CSNK2A20.57757505
73PNCK0.57119226
74STK30.55953434
75ACVR1B0.53489864
76ERBB20.52989774
77MARK30.52549808
78DMPK0.50439074
79BCR0.50122206
80CASK0.49859774
81BRAF0.49750052
82CDK20.49439990
83TEC0.46415068
84CSNK2A10.45586167
85RPS6KA50.44244177
86SIK20.42544443
87PRKCG0.42184387
88AURKA0.41411327
89PRKACB0.41071437
90EIF2AK20.38695699
91MINK10.37162730
92DYRK30.35318491
93PRKDC0.35251495
94CDK70.34588410
95PAK30.33766544
96STK38L0.33550513
97MAPK140.33353405
98PRKACA0.32655681
99GSK3B0.32373662
100FLT30.32082956

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.38006440
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08857124
3Homologous recombination_Homo sapiens_hsa034403.06568798
4Mismatch repair_Homo sapiens_hsa034303.03413693
5Fanconi anemia pathway_Homo sapiens_hsa034602.65029214
6One carbon pool by folate_Homo sapiens_hsa006702.64830943
7Oxidative phosphorylation_Homo sapiens_hsa001902.56323656
8Basal transcription factors_Homo sapiens_hsa030222.42944014
9DNA replication_Homo sapiens_hsa030302.42445364
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39636801
11Olfactory transduction_Homo sapiens_hsa047402.34882370
12Parkinsons disease_Homo sapiens_hsa050122.29875443
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23124044
14RNA polymerase_Homo sapiens_hsa030202.18344940
15RNA degradation_Homo sapiens_hsa030182.07427059
16RNA transport_Homo sapiens_hsa030132.05606866
17Huntingtons disease_Homo sapiens_hsa050161.95592277
18Nucleotide excision repair_Homo sapiens_hsa034201.94675354
19Proteasome_Homo sapiens_hsa030501.83672816
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81000085
21Propanoate metabolism_Homo sapiens_hsa006401.80599582
22Steroid biosynthesis_Homo sapiens_hsa001001.74721540
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69110860
24Butanoate metabolism_Homo sapiens_hsa006501.67995132
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67452182
26Nicotine addiction_Homo sapiens_hsa050331.47944836
27Spliceosome_Homo sapiens_hsa030401.43456798
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42763110
29Non-homologous end-joining_Homo sapiens_hsa034501.40028400
30Linoleic acid metabolism_Homo sapiens_hsa005911.36120854
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32879386
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31812027
33Cardiac muscle contraction_Homo sapiens_hsa042601.31075393
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.30449630
35Alzheimers disease_Homo sapiens_hsa050101.29378471
36Protein export_Homo sapiens_hsa030601.28361809
37Fatty acid biosynthesis_Homo sapiens_hsa000611.27891004
38Nitrogen metabolism_Homo sapiens_hsa009101.24248556
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22436948
40Tryptophan metabolism_Homo sapiens_hsa003801.20733228
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19294006
42Pyrimidine metabolism_Homo sapiens_hsa002401.09691303
43Phototransduction_Homo sapiens_hsa047441.07492986
44Taste transduction_Homo sapiens_hsa047421.06460653
45Purine metabolism_Homo sapiens_hsa002301.05203169
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03629109
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96130001
48Chemical carcinogenesis_Homo sapiens_hsa052040.89412703
49Cell cycle_Homo sapiens_hsa041100.84553186
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81300353
51Retinol metabolism_Homo sapiens_hsa008300.81183128
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80874508
53Asthma_Homo sapiens_hsa053100.80848374
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.80275842
55Pyruvate metabolism_Homo sapiens_hsa006200.79098334
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.77891316
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77401011
58Base excision repair_Homo sapiens_hsa034100.73735921
59Metabolic pathways_Homo sapiens_hsa011000.69082217
60Fat digestion and absorption_Homo sapiens_hsa049750.68093885
61Caffeine metabolism_Homo sapiens_hsa002320.68042729
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67045778
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.63771394
64Ether lipid metabolism_Homo sapiens_hsa005650.63602038
65Selenocompound metabolism_Homo sapiens_hsa004500.63407703
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63209393
67Fatty acid metabolism_Homo sapiens_hsa012120.60854500
68Peroxisome_Homo sapiens_hsa041460.59894264
69mRNA surveillance pathway_Homo sapiens_hsa030150.58066267
70Glutathione metabolism_Homo sapiens_hsa004800.57544489
71beta-Alanine metabolism_Homo sapiens_hsa004100.57120521
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56968442
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54568102
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50243015
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48339671
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48319710
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45512396
78Vitamin digestion and absorption_Homo sapiens_hsa049770.45423143
79Carbon metabolism_Homo sapiens_hsa012000.44956843
80Morphine addiction_Homo sapiens_hsa050320.42248361
81Oocyte meiosis_Homo sapiens_hsa041140.41233459
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.40445300
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38326097
84Lysine degradation_Homo sapiens_hsa003100.35948486
85Arginine and proline metabolism_Homo sapiens_hsa003300.34356110
86Arachidonic acid metabolism_Homo sapiens_hsa005900.34141219
87p53 signaling pathway_Homo sapiens_hsa041150.33668285
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32903271
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31603832
90Systemic lupus erythematosus_Homo sapiens_hsa053220.31078894
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27640580
92Serotonergic synapse_Homo sapiens_hsa047260.25746902
93Mineral absorption_Homo sapiens_hsa049780.25369282
94Glycerolipid metabolism_Homo sapiens_hsa005610.25297681
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22512016
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.20869474
97Fatty acid degradation_Homo sapiens_hsa000710.20381195
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.20338588
99GABAergic synapse_Homo sapiens_hsa047270.20020030
100Biosynthesis of amino acids_Homo sapiens_hsa012300.19403266

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