POSTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)8.10198338
2collagen fibril organization (GO:0030199)7.78608400
3bone trabecula formation (GO:0060346)6.62923212
4sequestering of extracellular ligand from receptor (GO:0035581)5.72755554
5extracellular fibril organization (GO:0043206)5.57532836
6chondrocyte proliferation (GO:0035988)5.18375571
7endodermal cell differentiation (GO:0035987)5.15832888
8collagen metabolic process (GO:0032963)5.13584969
9skin morphogenesis (GO:0043589)5.07497609
10collagen catabolic process (GO:0030574)5.07192105
11fibril organization (GO:0097435)4.86207426
12multicellular organismal macromolecule metabolic process (GO:0044259)4.83001797
13dermatan sulfate biosynthetic process (GO:0030208)4.81782001
14multicellular organismal catabolic process (GO:0044243)4.66417096
15multicellular organismal metabolic process (GO:0044236)4.56339846
16dermatan sulfate metabolic process (GO:0030205)4.36589653
17glomerular filtration (GO:0003094)4.34369140
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.32401724
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.31208046
20extracellular matrix disassembly (GO:0022617)4.27868345
21hemidesmosome assembly (GO:0031581)4.18206298
22keratan sulfate catabolic process (GO:0042340)4.14276270
23chondrocyte development (GO:0002063)4.00179006
24regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.95878720
25renal filtration (GO:0097205)3.90460665
26cell adhesion mediated by integrin (GO:0033627)3.87662037
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.86918764
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.85023316
29axon extension involved in axon guidance (GO:0048846)3.75601892
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.75601892
31extracellular matrix assembly (GO:0085029)3.75396757
32regulation of establishment of planar polarity (GO:0090175)3.64647043
33embryonic cranial skeleton morphogenesis (GO:0048701)3.63710634
34craniofacial suture morphogenesis (GO:0097094)3.62937178
35Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.62326897
36extracellular negative regulation of signal transduction (GO:1900116)3.61065341
37extracellular regulation of signal transduction (GO:1900115)3.61065341
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60323396
39negative regulation of chondrocyte differentiation (GO:0032331)3.60062380
40outer ear morphogenesis (GO:0042473)3.52848844
41cellular response to vitamin D (GO:0071305)3.52785483
42smooth muscle tissue development (GO:0048745)3.52276293
43positive regulation of osteoblast proliferation (GO:0033690)3.51491250
44basement membrane organization (GO:0071711)3.50939991
45vascular endothelial growth factor signaling pathway (GO:0038084)3.50718487
46* extracellular matrix organization (GO:0030198)3.40206479
47cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39952599
48* extracellular structure organization (GO:0043062)3.38734985
49camera-type eye morphogenesis (GO:0048593)3.38732598
50cellular response to vitamin (GO:0071295)3.38090296
51regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.36579460
52plasma membrane repair (GO:0001778)3.34475775
53mesenchymal-epithelial cell signaling (GO:0060638)3.33840805
54metanephric mesenchyme development (GO:0072075)3.30846044
55chondroitin sulfate biosynthetic process (GO:0030206)3.29739881
56glial cell migration (GO:0008347)3.29328258
57regulation of extracellular matrix disassembly (GO:0010715)3.24677740
58blood vessel maturation (GO:0001955)3.21204138
59actin filament depolymerization (GO:0030042)3.17864176
60insulin-like growth factor receptor signaling pathway (GO:0048009)3.16686460
61retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16525919
62stress fiber assembly (GO:0043149)3.15266653
63negative regulation of fatty acid transport (GO:2000192)3.14399329
64wound healing, spreading of cells (GO:0044319)3.13011489
65middle ear morphogenesis (GO:0042474)3.13009227
66regulation of integrin-mediated signaling pathway (GO:2001044)3.11299622
67positive regulation of mesenchymal cell proliferation (GO:0002053)3.09326113
68trabecula formation (GO:0060343)3.09183259
69non-canonical Wnt signaling pathway (GO:0035567)3.09150950
70positive regulation of blood vessel endothelial cell migration (GO:0043536)3.09007078
71face morphogenesis (GO:0060325)3.06795998
72peptidyl-proline hydroxylation (GO:0019511)3.06197100
73tooth mineralization (GO:0034505)3.05501778
74regulation of gastrulation (GO:0010470)3.05199126
75cell migration involved in sprouting angiogenesis (GO:0002042)3.01796389
76chondroitin sulfate catabolic process (GO:0030207)3.01609147
77regulation of transforming growth factor beta2 production (GO:0032909)3.01469307
78kidney mesenchyme development (GO:0072074)3.00577844
79negative regulation of cartilage development (GO:0061037)3.00552248
80regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.98615909
81cell-substrate junction assembly (GO:0007044)2.97844477
82hippo signaling (GO:0035329)2.97518682
83positive regulation of epithelial to mesenchymal transition (GO:0010718)2.96750255
84negative regulation of endothelial cell proliferation (GO:0001937)2.95720246
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94556260
86endocrine hormone secretion (GO:0060986)2.94197776
87wound healing, spreading of epidermal cells (GO:0035313)2.93247623
88negative regulation of catenin import into nucleus (GO:0035414)2.92454137
89negative regulation of embryonic development (GO:0045992)2.91333320
90regulation of mesenchymal cell proliferation (GO:0010464)2.90823148
91substrate-dependent cell migration (GO:0006929)2.88547499
92type B pancreatic cell proliferation (GO:0044342)2.88335860
93protein retention in ER lumen (GO:0006621)2.87418136
94COPII vesicle coating (GO:0048208)2.86525761
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.86478399
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.85207785
97regulation of osteoblast proliferation (GO:0033688)2.83513231
98endothelial cell morphogenesis (GO:0001886)2.82763665
99positive regulation of endothelial cell apoptotic process (GO:2000353)2.82319010
100peptide cross-linking (GO:0018149)2.82135094
101positive regulation of Rho protein signal transduction (GO:0035025)2.82120480
102negative regulation of smooth muscle cell migration (GO:0014912)2.81150124
103bone morphogenesis (GO:0060349)2.80131709
104positive regulation of odontogenesis (GO:0042482)2.80094442
105negative regulation of BMP signaling pathway (GO:0030514)2.79730109
106cochlea morphogenesis (GO:0090103)2.79510018
107Golgi transport vesicle coating (GO:0048200)2.78448313
108COPI coating of Golgi vesicle (GO:0048205)2.78448313
109wound healing (GO:0042060)2.77903880
110negative regulation of biomineral tissue development (GO:0070168)2.77319850
111regulation of cartilage development (GO:0061035)2.75422767
112glomerular basement membrane development (GO:0032836)2.73830658
113cell-substrate adhesion (GO:0031589)2.73576899
114cell-matrix adhesion (GO:0007160)2.73576056
115virion attachment to host cell (GO:0019062)2.72982647
116adhesion of symbiont to host cell (GO:0044650)2.72982647
117protein hydroxylation (GO:0018126)2.72716833
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72590289
119muscle cell migration (GO:0014812)2.71766627
120positive regulation of cartilage development (GO:0061036)2.71513749
121regulation of chondrocyte differentiation (GO:0032330)2.71461401
122cellular response to amino acid stimulus (GO:0071230)2.71333276
123endocardial cushion morphogenesis (GO:0003203)2.70681048
124cell migration involved in heart development (GO:0060973)2.70391539
125lung lobe morphogenesis (GO:0060463)2.70343320
126venous blood vessel morphogenesis (GO:0048845)2.70279338
127positive regulation of fibroblast migration (GO:0010763)2.69585450
128substrate adhesion-dependent cell spreading (GO:0034446)2.68872809
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68046428
130sprouting angiogenesis (GO:0002040)2.67577099
131convergent extension (GO:0060026)2.67195998
132paraxial mesoderm development (GO:0048339)2.67137308
133apoptotic cell clearance (GO:0043277)2.65011409
134cartilage condensation (GO:0001502)2.64961111
135cell aggregation (GO:0098743)2.64961111
136blood vessel remodeling (GO:0001974)2.64067938
137positive regulation of axon extension (GO:0045773)2.64061606
138endothelial cell proliferation (GO:0001935)2.64016538
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.60535113
140barbed-end actin filament capping (GO:0051016)2.60168538
141protein localization to cell surface (GO:0034394)2.59596336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.34495590
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.28978851
3* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.65147650
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.46884769
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.91186328
6* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.87696547
7* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.77524131
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.56431273
9* CJUN_26792858_Chip-Seq_BT549_Human2.53635633
10CLOCK_20551151_ChIP-Seq_293T_Human2.50412511
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42224720
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29759293
13* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.25064665
14* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.21787051
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.20057659
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17441592
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.11765502
18BRD4_25478319_ChIP-Seq_HGPS_Human2.10638391
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09400523
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07546271
21* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.06518541
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97412060
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96407660
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.94314091
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.94314091
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.91737473
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91332310
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77558211
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77383994
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77383994
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.76683078
32* TP53_18474530_ChIP-ChIP_U2OS_Human1.71981453
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62093880
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60681457
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60190152
36AR_21572438_ChIP-Seq_LNCaP_Human1.57306124
37TP53_16413492_ChIP-PET_HCT116_Human1.55832992
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53741154
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53208442
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48397894
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.44621474
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43199272
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39149871
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37003746
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37003746
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.36190149
47GBX2_23144817_ChIP-Seq_PC3_Human1.33907861
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31644471
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.31205118
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30648354
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.29320554
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28363335
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.26612967
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.26018428
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24050976
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24003973
57SOX2_20726797_ChIP-Seq_SW620_Human1.23520872
58SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23409560
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21978152
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.19828171
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19572696
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18983396
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16632154
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.15427683
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.15102200
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12325150
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12293295
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.11100420
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.10922080
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.10922080
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09250008
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.09106250
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07892969
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.07625266
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07085090
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06954149
77* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06411590
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04158500
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03611210
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.03171420
81* SA1_22415368_ChIP-Seq_MEFs_Mouse1.02751680
82BCAT_22108803_ChIP-Seq_LS180_Human1.02690916
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02630208
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.01785804
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99757655
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99454207
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99005645
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98517859
89TP63_23658742_ChIP-Seq_EP156T_Human0.98357320
90SMAD4_21799915_ChIP-Seq_A2780_Human0.98065777
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97052272
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96516691
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96087952
94TP53_23651856_ChIP-Seq_MEFs_Mouse0.96034679
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94846794
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94431029
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94405400
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93281359
99RXR_22108803_ChIP-Seq_LS180_Human0.92637635
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92624004
101AHR_22903824_ChIP-Seq_MCF-7_Human0.92561178
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91057809
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90806730
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90326017
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90117917
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89454242
107TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89296058
108TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89029508
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88513731
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88509453
111KDM2B_26808549_Chip-Seq_REH_Human0.88484468
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88344251
113* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88031229
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87351373
115TP53_22127205_ChIP-Seq_IMR90_Human0.87196258
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.87054537
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86736851
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86646792
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86331842
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86038089
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85555809
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.85052658
123* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84524889
124* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82611281
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82515881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.08939504
2MP0005503_abnormal_tendon_morphology6.76423064
3MP0005275_abnormal_skin_tensile6.27337779
4MP0003705_abnormal_hypodermis_morpholog3.65580107
5MP0001958_emphysema3.04005907
6MP0003279_aneurysm3.02861785
7MP0004272_abnormal_basement_membrane2.88576282
8MP0006054_spinal_hemorrhage2.80012330
9MP0002060_abnormal_skin_morphology2.72757888
10MP0009384_cardiac_valve_regurgitation2.51808457
11MP0005508_abnormal_skeleton_morphology2.34277526
12MP0002108_abnormal_muscle_morphology2.17293058
13MP0005257_abnormal_intraocular_pressure1.91129395
14MP0005623_abnormal_meninges_morphology1.82444150
15MP0003950_abnormal_plasma_membrane1.80022212
16MP0010030_abnormal_orbit_morphology1.71904818
17MP0003385_abnormal_body_wall1.66977815
18* MP0003566_abnormal_cell_adhesion1.66523365
19* MP0009250_abnormal_appendicular_skeleto1.63171177
20MP0002896_abnormal_bone_mineralization1.62656774
21MP0001542_abnormal_bone_strength1.58731210
22MP0001243_abnormal_dermal_layer1.52117093
23MP0002295_abnormal_pulmonary_circulatio1.44549775
24MP0010368_abnormal_lymphatic_system1.43572861
25MP0004134_abnormal_chest_morphology1.43560504
26MP0005023_abnormal_wound_healing1.36920144
27MP0000013_abnormal_adipose_tissue1.35919879
28MP0000733_abnormal_muscle_development1.27201931
29MP0005171_absent_coat_pigmentation1.26095695
30MP0000762_abnormal_tongue_morphology1.25213507
31MP0005390_skeleton_phenotype1.25107840
32MP0000751_myopathy1.24723360
33MP0002932_abnormal_joint_morphology1.23469221
34MP0001299_abnormal_eye_distance/1.23047504
35MP0000534_abnormal_ureter_morphology1.21338362
36MP0002282_abnormal_trachea_morphology1.20876537
37MP0009053_abnormal_anal_canal1.16422939
38MP0000749_muscle_degeneration1.16408783
39MP0000428_abnormal_craniofacial_morphol1.15083342
40MP0000163_abnormal_cartilage_morphology1.14719100
41* MP0002115_abnormal_skeleton_extremities1.14271652
42MP0003755_abnormal_palate_morphology1.14234947
43MP0000049_abnormal_middle_ear1.11130927
44MP0002249_abnormal_larynx_morphology1.09487656
45MP0003091_abnormal_cell_migration1.06679160
46MP0003045_fibrosis1.06265752
47MP0003942_abnormal_urinary_system1.02758766
48MP0002933_joint_inflammation1.02148139
49MP0010386_abnormal_urinary_bladder1.02087116
50MP0005595_abnormal_vascular_smooth1.00857676
51MP0000767_abnormal_smooth_muscle0.99917993
52* MP0002113_abnormal_skeleton_development0.99852196
53MP0002168_other_aberrant_phenotype0.99501880
54MP0002998_abnormal_bone_remodeling0.99266271
55* MP0003935_abnormal_craniofacial_develop0.96904012
56MP0003941_abnormal_skin_development0.96205352
57MP0003115_abnormal_respiratory_system0.95587580
58MP0010352_gastrointestinal_tract_polyps0.95466139
59* MP0000432_abnormal_head_morphology0.92800217
60MP0004858_abnormal_nervous_system0.92616704
61MP0003937_abnormal_limbs/digits/tail_de0.92485852
62MP0001879_abnormal_lymphatic_vessel0.90739386
63MP0005076_abnormal_cell_differentiation0.90181300
64MP0000003_abnormal_adipose_tissue0.89571452
65MP0010771_integument_phenotype0.88934758
66* MP0002109_abnormal_limb_morphology0.88271888
67MP0002877_abnormal_melanocyte_morpholog0.87927772
68MP0000579_abnormal_nail_morphology0.86142958
69MP0002233_abnormal_nose_morphology0.84033452
70* MP0002116_abnormal_craniofacial_bone0.81030298
71MP0005164_abnormal_response_to0.79770689
72MP0001849_ear_inflammation0.76867521
73MP0000462_abnormal_digestive_system0.75789342
74* MP0003795_abnormal_bone_structure0.75425576
75MP0003283_abnormal_digestive_organ0.74880310
76MP0003567_abnormal_fetal_cardiomyocyte0.74864662
77MP0002128_abnormal_blood_circulation0.71477363
78MP0004233_abnormal_muscle_weight0.71286393
79MP0000537_abnormal_urethra_morphology0.70912587
80MP0002938_white_spotting0.70666114
81* MP0003448_altered_tumor_morphology0.70215255
82MP0001270_distended_abdomen0.69628311
83MP0002111_abnormal_tail_morphology0.69132109
84MP0005369_muscle_phenotype0.68434924
85MP0006138_congestive_heart_failure0.68300026
86MP0005165_increased_susceptibility_to0.68029721
87MP0003300_gastrointestinal_ulcer0.66804049
88MP0002133_abnormal_respiratory_system0.66715335
89MP0005388_respiratory_system_phenotype0.66715335
90MP0009780_abnormal_chondrocyte_physiolo0.66321826
91MP0002177_abnormal_outer_ear0.65794158
92MP0001614_abnormal_blood_vessel0.65488880
93MP0000516_abnormal_urinary_system0.64971902
94MP0005367_renal/urinary_system_phenotyp0.64971902
95MP0001533_abnormal_skeleton_physiology0.64423001
96MP0002925_abnormal_cardiovascular_devel0.63594410
97MP0001175_abnormal_lung_morphology0.62254488
98MP0002837_dystrophic_cardiac_calcinosis0.62190902
99MP0003252_abnormal_bile_duct0.61907400
100MP0004185_abnormal_adipocyte_glucose0.61484368
101MP0001348_abnormal_lacrimal_gland0.60661527
102MP0003122_maternal_imprinting0.60455714
103MP0005620_abnormal_muscle_contractility0.60346624
104MP0000750_abnormal_muscle_regeneration0.60265804
105MP0005197_abnormal_uvea_morphology0.60234257
106* MP0002114_abnormal_axial_skeleton0.60166793
107MP0001340_abnormal_eyelid_morphology0.59319633
108MP0000759_abnormal_skeletal_muscle0.58968135
109MP0010234_abnormal_vibrissa_follicle0.58819655
110MP0001915_intracranial_hemorrhage0.58692165
111MP0005330_cardiomyopathy0.57980196
112MP0000427_abnormal_hair_cycle0.57535096
113MP0004084_abnormal_cardiac_muscle0.57375555
114MP0001177_atelectasis0.57366118
115MP0005193_abnormal_anterior_eye0.57057339
116MP0004087_abnormal_muscle_fiber0.55897466
117MP0004036_abnormal_muscle_relaxation0.55768353
118MP0003828_pulmonary_edema0.49960747
119MP0000467_abnormal_esophagus_morphology0.47453537
120MP0000538_abnormal_urinary_bladder0.46659736
121MP0000569_abnormal_digit_pigmentation0.46149600

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.74960906
2Premature rupture of membranes (HP:0001788)8.19375817
3Atrophic scars (HP:0001075)5.69826538
4Aortic dissection (HP:0002647)5.43986611
5Ankle contracture (HP:0006466)5.01993364
6Shallow orbits (HP:0000586)4.93438909
7Soft skin (HP:0000977)4.88930510
8Fragile skin (HP:0001030)4.77740595
9Broad metatarsal (HP:0001783)4.74186686
10Follicular hyperkeratosis (HP:0007502)4.32184257
11Peritonitis (HP:0002586)4.29419284
12Bladder diverticulum (HP:0000015)4.13016307
13Type 1 muscle fiber predominance (HP:0003803)4.10648301
14Abnormality of dentin (HP:0010299)3.95696266
15Dilatation of the ascending aorta (HP:0005111)3.90743284
16Neonatal short-limb short stature (HP:0008921)3.89883248
17Cerebral aneurysm (HP:0004944)3.88028259
18Mitral valve prolapse (HP:0001634)3.87186844
19Aortic aneurysm (HP:0004942)3.74191310
20Genu recurvatum (HP:0002816)3.71300877
21Blue sclerae (HP:0000592)3.44158864
22Biconcave vertebral bodies (HP:0004586)3.44016178
23Spinal rigidity (HP:0003306)3.42029859
24Wormian bones (HP:0002645)3.32656054
25Slender build (HP:0001533)3.22111651
26Cervical subluxation (HP:0003308)3.15183890
27Increased connective tissue (HP:0009025)3.12026618
28Hyperextensible skin (HP:0000974)3.09601133
29Abnormal delivery (HP:0001787)2.88557975
30Vertebral compression fractures (HP:0002953)2.87917486
31Spondylolisthesis (HP:0003302)2.85826072
32Mildly elevated creatine phosphokinase (HP:0008180)2.79879002
33Wide anterior fontanel (HP:0000260)2.78722719
34Osteolytic defects of the hand bones (HP:0009699)2.72315998
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.72315998
36Overgrowth (HP:0001548)2.71518791
37Joint laxity (HP:0001388)2.66798282
38Infantile muscular hypotonia (HP:0008947)2.64932805
39Bowel diverticulosis (HP:0005222)2.63149884
40Ectopia lentis (HP:0001083)2.61414346
41Absent frontal sinuses (HP:0002688)2.60246678
42Thin bony cortex (HP:0002753)2.59961010
43Distal arthrogryposis (HP:0005684)2.54100282
44Increased variability in muscle fiber diameter (HP:0003557)2.53416320
45Mitral regurgitation (HP:0001653)2.52446778
46Vascular tortuosity (HP:0004948)2.51380126
47Broad ribs (HP:0000885)2.50009698
48Elbow flexion contracture (HP:0002987)2.47377125
49Morphological abnormality of the middle ear (HP:0008609)2.41151284
50Calcaneovalgus deformity (HP:0001848)2.39999330
51Striae distensae (HP:0001065)2.39899312
52Deformed tarsal bones (HP:0008119)2.38359358
53Round ear (HP:0100830)2.38066202
54Short 4th metacarpal (HP:0010044)2.37629194
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37629194
56Abnormality of the acetabulum (HP:0003170)2.35451566
57Breech presentation (HP:0001623)2.35305120
58Wrist flexion contracture (HP:0001239)2.32557502
59Aortic valve stenosis (HP:0001650)2.30679978
60Joint stiffness (HP:0001387)2.30427747
61Deviation of the hallux (HP:0010051)2.30093221
62Ulnar deviation of the wrist (HP:0003049)2.29810239
63Alopecia of scalp (HP:0002293)2.28535853
64Disproportionate tall stature (HP:0001519)2.27949421
65Flat cornea (HP:0007720)2.27641208
66Increased corneal curvature (HP:0100692)2.26090917
67Keratoconus (HP:0000563)2.26090917
68Hallux valgus (HP:0001822)2.19317962
69Osteoarthritis (HP:0002758)2.18463138
70Abnormality of skeletal muscle fiber size (HP:0012084)2.17949128
71Arterial tortuosity (HP:0005116)2.15196354
72Aneurysm (HP:0002617)2.14201711
73Coronal craniosynostosis (HP:0004440)2.12367555
74Aortic regurgitation (HP:0001659)2.12042374
75Camptodactyly of toe (HP:0001836)2.07716611
76Venous abnormality (HP:0002624)2.07652979
77Asymmetry of the thorax (HP:0001555)2.06861539
78Tibial bowing (HP:0002982)2.05844622
79Inguinal hernia (HP:0000023)2.03155192
80Subacute progressive viral hepatitis (HP:0006572)2.02552995
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02533094
82Venous insufficiency (HP:0005293)2.02346044
83Ovoid vertebral bodies (HP:0003300)1.99492830
84Nonimmune hydrops fetalis (HP:0001790)1.99466956
85Popliteal pterygium (HP:0009756)1.99050724
86Trismus (HP:0000211)1.98427270
87Flared iliac wings (HP:0002869)1.97073901
88Hypoplastic ischia (HP:0003175)1.95952310
89Abnormality of the peritoneum (HP:0002585)1.95554427
90Pulmonary artery stenosis (HP:0004415)1.94860495
91Delayed cranial suture closure (HP:0000270)1.91396849
92Femoral bowing (HP:0002980)1.90600692
93Redundant skin (HP:0001582)1.90457755
94Mild short stature (HP:0003502)1.89902857
95Thin skin (HP:0000963)1.89502105
96Protruding ear (HP:0000411)1.88202418
97Cupped ribs (HP:0000887)1.88122235
98Decreased skull ossification (HP:0004331)1.87621244
99Limited hip movement (HP:0008800)1.86676953
100Broad long bones (HP:0005622)1.86398856
101Bell-shaped thorax (HP:0001591)1.85390298
102Knee flexion contracture (HP:0006380)1.84716561
103Osteopenia (HP:0000938)1.84555131
104Buphthalmos (HP:0000557)1.84476156
105Abnormality of the ischium (HP:0003174)1.82248582
106Abnormality of the 4th metacarpal (HP:0010012)1.81992223
107Hypoplasia of the iris (HP:0007676)1.80881547
108Delayed closure of the anterior fontanelle (HP:0001476)1.79125789
109Joint contractures involving the joints of the feet (HP:0100492)1.76912369
110Flexion contracture of toe (HP:0005830)1.76912369
111Thin ribs (HP:0000883)1.76131972
112Hip contracture (HP:0003273)1.72908007
113Generalized amyotrophy (HP:0003700)1.71313721
114Abnormality of skull ossification (HP:0002703)1.69525344
115Mesomelia (HP:0003027)1.68752318
116Ulnar bowing (HP:0003031)1.68259365
117Syringomyelia (HP:0003396)1.67404114
118Spinal cord lesions (HP:0100561)1.67404114
119Mitral stenosis (HP:0001718)1.63159267
120Hypoventilation (HP:0002791)1.62660689
121Abnormality of the anterior chamber (HP:0000593)1.62063365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.96134467
2DDR24.50901504
3EPHA34.41671669
4PDGFRA3.29235672
5TTN3.01823769
6TRIB32.85851210
7SIK12.80785379
8EPHB22.68852282
9LATS22.68389481
10ERN12.58136083
11STK32.50394758
12STK38L2.47444299
13TGFBR22.16287983
14PKN21.98984687
15MAP3K61.85747386
16STK241.82689429
17MUSK1.78364097
18DMPK1.69428500
19PIK3CA1.66559058
20PAK21.61545125
21FER1.57716185
22MET1.57665712
23FGFR21.56926447
24RIPK11.46966760
25FGFR11.45792008
26MST1R1.44315330
27TRPM71.40982675
28FRK1.40717016
29NEK91.40626880
30NUAK11.37691893
31TGFBR11.33616140
32PTK61.29870431
33MYLK1.28271647
34BMX1.24998722
35PTK21.19430920
36PDGFRB1.19220239
37EPHB11.19137543
38ERBB31.15559742
39LRRK21.13302609
40PAK31.12944956
41PTK2B1.09946686
42PLK21.07643600
43ROCK11.02517799
44FGFR31.01771280
45ILK0.98398574
46PAK40.95571015
47ACVR1B0.92634010
48CAMK1D0.87855229
49FGFR40.86645833
50PRKCH0.82180995
51MTOR0.81027360
52MAP3K100.80661153
53PRKG20.80084314
54JAK10.78355036
55DAPK30.78185373
56CDK60.74120145
57PIK3CG0.74015264
58NTRK10.70361974
59ERBB40.69232730
60PRKD10.67053234
61RET0.62149794
62BMPR1B0.61826550
63MAP3K120.61320406
64MAP3K30.61143751
65ERBB20.60981392
66RPS6KA20.60667840
67EEF2K0.59977866
68ROCK20.58765493
69RPS6KA40.58584183
70MAP2K10.57649268
71PRKD20.56989278
72INSR0.54834605
73ADRBK10.53716920
74FLT30.53496858
75CDC42BPA0.53308561
76AKT30.51399020
77GSK3A0.50413897
78KIT0.49965569
79CAMK1G0.49944188
80CLK10.49250109
81JAK30.46955373
82MELK0.46884264
83PRKCE0.46200259
84MAPK120.45962710
85IGF1R0.44718245
86TESK10.44572251
87ZAK0.39469643
88STK380.39294976
89ICK0.39178753
90CDK80.39071118
91TIE10.38197841
92SRC0.38130599
93MAP2K30.36039149
94STK390.34697711
95CDK90.33603605
96OBSCN0.32221722
97MOS0.31825007
98CAMK2G0.31279406
99MAPK10.30065150
100MARK20.29735422
101LMTK20.26801744
102MARK10.26539391
103MAPKAPK50.26336773
104PAK60.25693233
105MAP3K20.25516036
106MAP3K70.25159212
107PRKG10.24768715
108ZAP700.24165259
109WNK10.24138625
110OXSR10.23042149
111LIMK10.22113534
112TYK20.22089381
113ABL10.21429554
114PDK40.18721075
115PDK30.18721075
116ABL20.17119168
117IRAK10.15846526
118MAPKAPK20.15315393
119MAPKAPK30.14884942
120NLK0.14729830
121MAPK70.14684759
122PRKD30.13742824
123MAPK30.13739583
124KSR10.13005592

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.17171404
2Protein digestion and absorption_Homo sapiens_hsa049743.55989605
3Focal adhesion_Homo sapiens_hsa045103.23751287
4Amoebiasis_Homo sapiens_hsa051462.62395157
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35418319
6Proteoglycans in cancer_Homo sapiens_hsa052052.34263619
7Dilated cardiomyopathy_Homo sapiens_hsa054142.31455582
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.30703370
9Malaria_Homo sapiens_hsa051442.23228790
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22736902
11Adherens junction_Homo sapiens_hsa045202.20185727
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18906017
13TGF-beta signaling pathway_Homo sapiens_hsa043502.08850862
14Basal cell carcinoma_Homo sapiens_hsa052171.98366463
15Hippo signaling pathway_Homo sapiens_hsa043901.79278930
16Small cell lung cancer_Homo sapiens_hsa052221.79167998
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.76879271
18Hedgehog signaling pathway_Homo sapiens_hsa043401.64833717
19MicroRNAs in cancer_Homo sapiens_hsa052061.59977698
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58107660
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55776513
22Wnt signaling pathway_Homo sapiens_hsa043101.42330276
23Bladder cancer_Homo sapiens_hsa052191.39229566
24Melanoma_Homo sapiens_hsa052181.38349590
25Chronic myeloid leukemia_Homo sapiens_hsa052201.37299461
26Platelet activation_Homo sapiens_hsa046111.24536425
27Viral myocarditis_Homo sapiens_hsa054161.23157768
28Toxoplasmosis_Homo sapiens_hsa051451.20406179
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20117498
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18245798
31Prostate cancer_Homo sapiens_hsa052151.17378189
32Pathways in cancer_Homo sapiens_hsa052001.17034869
33Axon guidance_Homo sapiens_hsa043601.16566691
34Pancreatic cancer_Homo sapiens_hsa052121.16153632
35Glioma_Homo sapiens_hsa052141.10952336
36Dorso-ventral axis formation_Homo sapiens_hsa043201.07698757
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.04334818
38Melanogenesis_Homo sapiens_hsa049161.00243190
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98196173
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96163101
41Rap1 signaling pathway_Homo sapiens_hsa040150.93555858
42Tight junction_Homo sapiens_hsa045300.90721859
43Renin-angiotensin system_Homo sapiens_hsa046140.88413138
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86115483
45Colorectal cancer_Homo sapiens_hsa052100.82801759
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.79353353
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79002386
48HTLV-I infection_Homo sapiens_hsa051660.78799433
49TNF signaling pathway_Homo sapiens_hsa046680.78551092
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.76557947
51Insulin resistance_Homo sapiens_hsa049310.75789348
52p53 signaling pathway_Homo sapiens_hsa041150.75690474
53Thyroid hormone synthesis_Homo sapiens_hsa049180.70704151
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69027536
55Estrogen signaling pathway_Homo sapiens_hsa049150.68968747
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.68620465
57Circadian rhythm_Homo sapiens_hsa047100.67228178
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.66567442
59Renal cell carcinoma_Homo sapiens_hsa052110.64036758
60Hepatitis B_Homo sapiens_hsa051610.63416128
61Ras signaling pathway_Homo sapiens_hsa040140.62660099
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62478405
63Endometrial cancer_Homo sapiens_hsa052130.62177640
64Phagosome_Homo sapiens_hsa041450.61520105
65Prion diseases_Homo sapiens_hsa050200.60850002
66Leishmaniasis_Homo sapiens_hsa051400.57165025
67FoxO signaling pathway_Homo sapiens_hsa040680.56856994
68Osteoclast differentiation_Homo sapiens_hsa043800.55515862
69Gap junction_Homo sapiens_hsa045400.54995469
70Lysine degradation_Homo sapiens_hsa003100.54774746
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53828405
72Notch signaling pathway_Homo sapiens_hsa043300.53483095
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53049722
74Choline metabolism in cancer_Homo sapiens_hsa052310.53016625
75Oxytocin signaling pathway_Homo sapiens_hsa049210.52676416
76GnRH signaling pathway_Homo sapiens_hsa049120.52486511
77Salmonella infection_Homo sapiens_hsa051320.51735382
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51335969
79Lysosome_Homo sapiens_hsa041420.51307580
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50997119
81Vibrio cholerae infection_Homo sapiens_hsa051100.50448491
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50439741
83Renin secretion_Homo sapiens_hsa049240.50087075
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49054942
85Other glycan degradation_Homo sapiens_hsa005110.49005698
86Complement and coagulation cascades_Homo sapiens_hsa046100.48980274
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48037276
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47917657
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47236175
90Starch and sucrose metabolism_Homo sapiens_hsa005000.47090484
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45539010
92Ovarian steroidogenesis_Homo sapiens_hsa049130.45391562
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.43845376
94mTOR signaling pathway_Homo sapiens_hsa041500.43838699
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43648727
96Endocytosis_Homo sapiens_hsa041440.43439477
97Shigellosis_Homo sapiens_hsa051310.43301459
98Pertussis_Homo sapiens_hsa051330.42787510
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42742232
100AMPK signaling pathway_Homo sapiens_hsa041520.41490792
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.40631486
102Thyroid cancer_Homo sapiens_hsa052160.40408904
103MAPK signaling pathway_Homo sapiens_hsa040100.39462465
104HIF-1 signaling pathway_Homo sapiens_hsa040660.38700974
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.38310557
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37971602
107Caffeine metabolism_Homo sapiens_hsa002320.37824125
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37373250
109Insulin signaling pathway_Homo sapiens_hsa049100.37048641
110PPAR signaling pathway_Homo sapiens_hsa033200.36769895
111Cocaine addiction_Homo sapiens_hsa050300.36494790
112N-Glycan biosynthesis_Homo sapiens_hsa005100.36097188
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35589091
114African trypanosomiasis_Homo sapiens_hsa051430.35564673
115cAMP signaling pathway_Homo sapiens_hsa040240.35163064
116Gastric acid secretion_Homo sapiens_hsa049710.34983943
117VEGF signaling pathway_Homo sapiens_hsa043700.34897967
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34850896
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.34374660
120Calcium signaling pathway_Homo sapiens_hsa040200.33462001
121Prolactin signaling pathway_Homo sapiens_hsa049170.31874755

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »