POPDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.69354309
2sarcomere organization (GO:0045214)9.52504053
3myofibril assembly (GO:0030239)8.37514890
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.07294987
5actin-myosin filament sliding (GO:0033275)7.64940573
6muscle filament sliding (GO:0030049)7.64940573
7negative regulation of potassium ion transmembrane transport (GO:1901380)7.37399923
8cardiac muscle contraction (GO:0060048)7.35289883
9cardiac muscle tissue morphogenesis (GO:0055008)6.63529913
10tricarboxylic acid cycle (GO:0006099)6.60720312
11* cardiac muscle cell development (GO:0055013)6.56128998
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.54464098
13actin-mediated cell contraction (GO:0070252)6.39154481
14ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.36779615
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.29169845
16regulation of actin filament-based movement (GO:1903115)6.25363902
17actomyosin structure organization (GO:0031032)6.18877920
18* cardiac cell development (GO:0055006)6.16166341
19regulation of relaxation of muscle (GO:1901077)6.15919676
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.13203121
21cardiac muscle hypertrophy (GO:0003300)6.13195297
22adult heart development (GO:0007512)6.10552158
23muscle tissue morphogenesis (GO:0060415)5.91849313
24heart contraction (GO:0060047)5.91193990
25heart process (GO:0003015)5.91193990
26ventricular cardiac muscle cell action potential (GO:0086005)5.87744437
27regulation of sarcomere organization (GO:0060297)5.84679267
28striated muscle hypertrophy (GO:0014897)5.79614774
29bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75884028
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.73716624
31cardiac ventricle formation (GO:0003211)5.64770170
32heart trabecula formation (GO:0060347)5.62374721
33striated muscle contraction (GO:0006941)5.53574946
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.53132873
35plasma membrane repair (GO:0001778)5.39562647
36regulation of skeletal muscle contraction (GO:0014819)5.31366543
37regulation of the force of heart contraction (GO:0002026)5.28506269
38negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.23570141
39muscle hypertrophy (GO:0014896)5.15642047
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.14478255
41regulation of striated muscle contraction (GO:0006942)5.10504292
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99671761
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.96369761
44carnitine shuttle (GO:0006853)4.88991491
45actin filament-based movement (GO:0030048)4.76772208
46negative regulation of striated muscle cell apoptotic process (GO:0010664)4.69264811
47regulation of cardioblast differentiation (GO:0051890)4.68898766
48cell communication involved in cardiac conduction (GO:0086065)4.68101829
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.67088444
50regulation of acyl-CoA biosynthetic process (GO:0050812)4.67087686
51regulation of membrane repolarization (GO:0060306)4.67017532
52regulation of cell communication by electrical coupling (GO:0010649)4.64311207
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62373092
54ATP synthesis coupled proton transport (GO:0015986)4.62373092
55atrial septum morphogenesis (GO:0060413)4.47483658
56oxidative phosphorylation (GO:0006119)4.43429133
57ventricular cardiac muscle cell development (GO:0055015)4.43202921
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.31965301
59regulation of coenzyme metabolic process (GO:0051196)4.31564195
60regulation of cofactor metabolic process (GO:0051193)4.31564195
61response to inactivity (GO:0014854)4.31071170
62cardiac muscle adaptation (GO:0014887)4.30768599
63cardiac muscle hypertrophy in response to stress (GO:0014898)4.30768599
64muscle hypertrophy in response to stress (GO:0003299)4.30768599
65sarcoplasmic reticulum calcium ion transport (GO:0070296)4.29528373
66cell communication by electrical coupling (GO:0010644)4.25000072
67fatty acid transmembrane transport (GO:1902001)4.22834983
68regulation of cardiac muscle contraction (GO:0055117)4.17194587
69regulation of cardiac muscle cell contraction (GO:0086004)4.17125475
70negative regulation of protein localization to cell surface (GO:2000009)4.15736181
71respiratory electron transport chain (GO:0022904)4.13382869
72cardiac muscle cell action potential involved in contraction (GO:0086002)4.11825203
73cardiac muscle tissue development (GO:0048738)4.11296560
74regulation of ATP catabolic process (GO:1903289)4.08532027
75regulation of ATPase activity (GO:0043462)4.08532027
76cardiac muscle cell action potential (GO:0086001)4.05699896
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02056194
78electron transport chain (GO:0022900)4.01676958
79detection of calcium ion (GO:0005513)4.00077769
80response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.96162558
81relaxation of cardiac muscle (GO:0055119)3.96014308
82negative regulation of potassium ion transport (GO:0043267)3.93210680
83* regulation of heart rate (GO:0002027)3.89683029
84adrenergic receptor signaling pathway (GO:0071875)3.85303467
85negative regulation of myotube differentiation (GO:0010832)3.83196613
86cellular response to epinephrine stimulus (GO:0071872)3.77080863
87positive regulation of action potential (GO:0045760)3.72151689
88NADH metabolic process (GO:0006734)3.70580427
89response to epinephrine (GO:0071871)3.69835623
90* regulation of heart contraction (GO:0008016)3.68092719
91regulation of striated muscle cell apoptotic process (GO:0010662)3.67840842
92trabecula formation (GO:0060343)3.65402121
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.65293689
94regulation of calcium ion transmembrane transport (GO:1903169)3.65293689
95cardiac conduction (GO:0061337)3.64686782
96positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59457621
97positive regulation of ATPase activity (GO:0032781)3.58922460
98positive regulation of ATP catabolic process (GO:1903291)3.58922460
99carnitine transmembrane transport (GO:1902603)3.58811469
100regulation of heart rate by cardiac conduction (GO:0086091)3.57049926
101* striated muscle cell development (GO:0055002)3.56660965
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.54227926
103regulation of muscle system process (GO:0090257)3.53492908
104regulation of muscle contraction (GO:0006937)3.51336527
105cardiac chamber formation (GO:0003207)3.50821775
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49239559
1072-oxoglutarate metabolic process (GO:0006103)3.46533866
108atrioventricular valve morphogenesis (GO:0003181)3.46458954
109regulation of sulfur metabolic process (GO:0042762)3.45647622
110muscle contraction (GO:0006936)3.42222617
111negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40112949
112response to caffeine (GO:0031000)3.39119948
113relaxation of muscle (GO:0090075)3.36339797
114positive regulation of heart contraction (GO:0045823)3.32720659
115positive regulation of cation channel activity (GO:2001259)3.32509181
116positive regulation of heart rate (GO:0010460)3.28808931
117potassium ion export (GO:0071435)3.27352393
118regulation of cardiac muscle cell apoptotic process (GO:0010665)3.27203110
119positive regulation of sodium ion transport (GO:0010765)3.25843874
120outflow tract septum morphogenesis (GO:0003148)3.25648443
121amino-acid betaine transport (GO:0015838)3.25513980
122carnitine transport (GO:0015879)3.25513980
123muscle system process (GO:0003012)3.23641461
124striated muscle adaptation (GO:0014888)3.22325385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.41053572
2* EP300_21415370_ChIP-Seq_HL-1_Mouse5.86237950
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.09208686
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.54035012
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.47076675
6TBX20_22328084_ChIP-Seq_HEART_Mouse4.47076675
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.99242432
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.95287051
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.42783013
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.41061552
11* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.99544674
12ZNF263_19887448_ChIP-Seq_K562_Human2.84556102
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.68643223
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65101468
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.63757090
16NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.22441111
17PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.07440120
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05533641
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98824179
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89915116
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.85774961
22GATA1_22025678_ChIP-Seq_K562_Human1.83174975
23CLOCK_20551151_ChIP-Seq_293T_Human1.75254945
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74028204
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72508047
26VDR_22108803_ChIP-Seq_LS180_Human1.65138764
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63468624
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59192632
29ISL1_27105846_Chip-Seq_CPCs_Mouse1.58250215
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57109291
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55051105
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51591057
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.45728663
34EZH2_22144423_ChIP-Seq_EOC_Human1.44705846
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42449691
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39287143
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.33305174
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32080383
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.31656522
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25555580
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25521303
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24339623
43GATA1_19941826_ChIP-Seq_K562_Human1.24281911
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23698623
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23698623
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21972783
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21341452
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19966308
49GBX2_23144817_ChIP-Seq_PC3_Human1.18768676
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18720761
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17091483
52SMAD4_21799915_ChIP-Seq_A2780_Human1.16693886
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16483788
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16315891
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15668897
56* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11797974
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.11581791
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10765641
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09429338
60TP63_22573176_ChIP-Seq_HFKS_Human1.07745710
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.07721433
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07566799
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04673373
64SPI1_20517297_ChIP-Seq_HL60_Human1.03041510
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.02596035
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01947852
67KDM2B_26808549_Chip-Seq_DND41_Human1.01569412
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.01521057
69CTCF_27219007_Chip-Seq_Bcells_Human1.00133317
70* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98634897
71ATF3_27146783_Chip-Seq_COLON_Human0.97768737
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97630092
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97175387
74WT1_19549856_ChIP-ChIP_CCG9911_Human0.96932861
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95649030
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95546779
77* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95512499
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95212997
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94795414
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.94065874
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93386958
82DROSHA_22980978_ChIP-Seq_HELA_Human0.93337941
83SOX2_21211035_ChIP-Seq_LN229_Gbm0.93191877
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92837617
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92255213
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92086436
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.92014417
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91869833
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91785806
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91312972
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91270294
92TP53_16413492_ChIP-PET_HCT116_Human0.91225675
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90806163
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90224333
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89726149
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89726149
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89541308
98* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89352999
99RACK7_27058665_Chip-Seq_MCF-7_Human0.89321352
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.89305593
101GATA2_19941826_ChIP-Seq_K562_Human0.88913393
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88112171
103TBL1_22424771_ChIP-Seq_293T_Human0.87440215
104SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87365041
105CJUN_26792858_Chip-Seq_BT549_Human0.86608862
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.86181562
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85647643
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85549428
109TCF4_23295773_ChIP-Seq_U87_Human0.85222758
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85154476
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84766796
112OCT4_20526341_ChIP-Seq_ESCs_Human0.84320325
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.84059708
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83874037
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83417536
116* GF1_26923725_Chip-Seq_HPCs_Mouse0.82711884
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81946352
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.81836035
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81787887
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.80586710
121ZNF274_21170338_ChIP-Seq_K562_Hela0.80343625
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.79587838
123* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79454498
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79267820
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79105628
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79099928
127* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77470554
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.76940696
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76918891
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75077819
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.73893342
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73786586
133LXR_22292898_ChIP-Seq_THP-1_Human0.73535383
134* GATA1_19941827_ChIP-Seq_MEL_Mouse0.72879972
135FOXH1_21741376_ChIP-Seq_ESCs_Human0.71835109
136P68_20966046_ChIP-Seq_HELA_Human0.71492457
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.71228158
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69943514
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69836405
140* TP53_23651856_ChIP-Seq_MEFs_Mouse0.69241387
141BCAT_22108803_ChIP-Seq_LS180_Human0.69032600
142SPI1_23127762_ChIP-Seq_K562_Human0.68377643
143BCOR_27268052_Chip-Seq_Bcells_Human0.67833034
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.67814959
145BCL6_27268052_Chip-Seq_Bcells_Human0.67697618
146* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.67067131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.62191048
2MP0004084_abnormal_cardiac_muscle6.41658705
3MP0003646_muscle_fatigue5.04250240
4MP0004215_abnormal_myocardial_fiber4.83961419
5MP0000751_myopathy4.77583383
6MP0004036_abnormal_muscle_relaxation4.54040029
7MP0005330_cardiomyopathy4.14095737
8MP0000749_muscle_degeneration4.05334736
9MP0002972_abnormal_cardiac_muscle3.47199293
10MP0008775_abnormal_heart_ventricle3.27236110
11MP0004087_abnormal_muscle_fiber3.11493434
12MP0003137_abnormal_impulse_conducting3.06010365
13MP0010630_abnormal_cardiac_muscle2.83052437
14MP0005620_abnormal_muscle_contractility2.80961277
15MP0005385_cardiovascular_system_phenoty2.80365505
16MP0001544_abnormal_cardiovascular_syste2.80365505
17MP0006138_congestive_heart_failure2.62868494
18MP0000750_abnormal_muscle_regeneration2.56369658
19MP0003828_pulmonary_edema2.49610917
20MP0004484_altered_response_of2.44495647
21MP0002106_abnormal_muscle_physiology2.43292239
22MP0004085_abnormal_heartbeat2.31749832
23MP0003221_abnormal_cardiomyocyte_apopto2.24386938
24MP0002269_muscular_atrophy2.20978010
25MP0004510_myositis2.19524751
26MP0004130_abnormal_muscle_cell2.16205063
27MP0004145_abnormal_muscle_electrophysio2.04420285
28MP0005369_muscle_phenotype1.94571029
29MP0002127_abnormal_cardiovascular_syste1.89818501
30MP0000759_abnormal_skeletal_muscle1.78655250
31MP0000747_muscle_weakness1.75402809
32MP0003950_abnormal_plasma_membrane1.74696163
33MP0006036_abnormal_mitochondrial_physio1.72428047
34MP0004233_abnormal_muscle_weight1.65337493
35MP0003567_abnormal_fetal_cardiomyocyte1.64502731
36MP0002332_abnormal_exercise_endurance1.32439884
37MP0000266_abnormal_heart_morphology1.26894164
38MP0003279_aneurysm1.21006750
39MP0010368_abnormal_lymphatic_system1.15768590
40MP0005666_abnormal_adipose_tissue1.14995735
41MP0000343_altered_response_to1.13800616
42MP0005451_abnormal_body_composition1.06636337
43MP0002234_abnormal_pharynx_morphology1.03887759
44MP0006035_abnormal_mitochondrial_morpho1.02093554
45MP0005165_increased_susceptibility_to1.00986269
46MP0005670_abnormal_white_adipose0.99303241
47MP0001661_extended_life_span0.93841445
48MP0003566_abnormal_cell_adhesion0.91281083
49MP0000230_abnormal_systemic_arterial0.86677041
50MP0002128_abnormal_blood_circulation0.86590272
51MP0004272_abnormal_basement_membrane0.81344522
52MP0003806_abnormal_nucleotide_metabolis0.76601045
53MP0005266_abnormal_metabolism0.76239823
54MP0005375_adipose_tissue_phenotype0.74252242
55MP0005623_abnormal_meninges_morphology0.71417247
56MP0000767_abnormal_smooth_muscle0.71167484
57MP0004185_abnormal_adipocyte_glucose0.69997053
58MP0008004_abnormal_stomach_pH0.69859709
59MP0003705_abnormal_hypodermis_morpholog0.68685651
60MP0002108_abnormal_muscle_morphology0.65804627
61MP0001879_abnormal_lymphatic_vessel0.65276317
62MP0003984_embryonic_growth_retardation0.59555553
63MP0002088_abnormal_embryonic_growth/wei0.58830850
64MP0002925_abnormal_cardiovascular_devel0.58814033
65MP0009384_cardiac_valve_regurgitation0.56782222
66MP0008438_abnormal_cutaneous_collagen0.54795094
67MP0004147_increased_porphyrin_level0.51714455
68MP0003045_fibrosis0.51527948
69MP0000733_abnormal_muscle_development0.48959754
70MP0002909_abnormal_adrenal_gland0.46815538
71MP0001784_abnormal_fluid_regulation0.45810012
72MP0001614_abnormal_blood_vessel0.44693799
73MP0000003_abnormal_adipose_tissue0.43790727
74MP0004043_abnormal_pH_regulation0.42220060
75MP0005319_abnormal_enzyme/_coenzyme0.42205535
76MP0000013_abnormal_adipose_tissue0.40867772
77MP0005187_abnormal_penis_morphology0.40561033
78MP0002638_abnormal_pupillary_reflex0.39469309
79MP0005275_abnormal_skin_tensile0.38266254
80MP0003122_maternal_imprinting0.37416260
81MP0005380_embryogenesis_phenotype0.36394814
82MP0001672_abnormal_embryogenesis/_devel0.36394814
83MP0005409_darkened_coat_color0.35034091
84MP0002078_abnormal_glucose_homeostasis0.33920766
85MP0001984_abnormal_olfaction0.33903758
86MP0005595_abnormal_vascular_smooth0.33690719
87MP0002971_abnormal_brown_adipose0.32775212
88MP0003948_abnormal_gas_homeostasis0.32526666
89MP0008569_lethality_at_weaning0.31633230
90MP0005377_hearing/vestibular/ear_phenot0.28564037
91MP0003878_abnormal_ear_physiology0.28564037
92MP0003941_abnormal_skin_development0.27935289
93MP0008874_decreased_physiological_sensi0.27591208
94MP0001727_abnormal_embryo_implantation0.25981031
95MP0002133_abnormal_respiratory_system0.24292301
96MP0005388_respiratory_system_phenotype0.24292301
97MP0001299_abnormal_eye_distance/0.23136972
98MP0003136_yellow_coat_color0.22542208
99MP0005535_abnormal_body_temperature0.20918596
100MP0000249_abnormal_blood_vessel0.20909531
101MP0008961_abnormal_basal_metabolism0.20235287
102MP0005584_abnormal_enzyme/coenzyme_acti0.19872691
103MP0000579_abnormal_nail_morphology0.18899814
104MP0002102_abnormal_ear_morphology0.18456012
105MP0003091_abnormal_cell_migration0.16837350
106MP0005376_homeostasis/metabolism_phenot0.16729908
107MP0002295_abnormal_pulmonary_circulatio0.16649077
108MP0005386_behavior/neurological_phenoty0.16597334
109MP0004924_abnormal_behavior0.16597334
110MP0002933_joint_inflammation0.16289493
111MP0005334_abnormal_fat_pad0.15979987
112MP0005167_abnormal_blood-brain_barrier0.15850685
113MP0000462_abnormal_digestive_system0.15737366
114MP0001175_abnormal_lung_morphology0.15663507
115MP0001697_abnormal_embryo_size0.15290596
116MP0001958_emphysema0.15247114
117MP0005503_abnormal_tendon_morphology0.14375879
118MP0003935_abnormal_craniofacial_develop0.14213904
119MP0009115_abnormal_fat_cell0.12897840
120MP0001529_abnormal_vocalization0.11205716

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.58929204
2Ventricular tachycardia (HP:0004756)7.18222401
3Atrial fibrillation (HP:0005110)6.53971121
4Calf muscle hypertrophy (HP:0008981)6.31790449
5Exercise-induced muscle cramps (HP:0003710)6.14668003
6Primary atrial arrhythmia (HP:0001692)6.10740422
7Supraventricular tachycardia (HP:0004755)5.91273705
8Lipoatrophy (HP:0100578)5.80425802
9Supraventricular arrhythmia (HP:0005115)5.79583448
10Muscle hypertrophy of the lower extremities (HP:0008968)5.69014693
11Abnormality of the left ventricular outflow tract (HP:0011103)5.61746236
12Subaortic stenosis (HP:0001682)5.61746236
13Exercise-induced myalgia (HP:0003738)5.61084852
14Abnormality of the calf musculature (HP:0001430)5.30392280
15Right ventricular cardiomyopathy (HP:0011663)5.15736010
16Syncope (HP:0001279)5.11724936
17Muscle fiber splitting (HP:0003555)5.08253087
18Myoglobinuria (HP:0002913)4.83597786
19Dilated cardiomyopathy (HP:0001644)4.73854340
20Hyporeflexia of lower limbs (HP:0002600)4.72870385
21Palpitations (HP:0001962)4.67409110
22Prolonged QT interval (HP:0001657)4.62259139
23Ventricular arrhythmia (HP:0004308)4.43788969
24Bundle branch block (HP:0011710)4.40357414
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.16458834
26Asymmetric septal hypertrophy (HP:0001670)4.06195169
27EMG: myopathic abnormalities (HP:0003458)4.05854081
28Muscle fiber inclusion bodies (HP:0100299)4.04240572
29Ventricular fibrillation (HP:0001663)3.96202806
30Rhabdomyolysis (HP:0003201)3.80153739
31Heart block (HP:0012722)3.78765078
32Atrioventricular block (HP:0001678)3.74898186
33Abnormal atrioventricular conduction (HP:0005150)3.56533659
34Nemaline bodies (HP:0003798)3.50364720
35Increased connective tissue (HP:0009025)3.39296114
36Abnormal EKG (HP:0003115)3.34164092
37Left ventricular hypertrophy (HP:0001712)3.19426265
38Abnormal mitochondria in muscle tissue (HP:0008316)3.09961533
39Hepatic necrosis (HP:0002605)3.09168661
40Myotonia (HP:0002486)3.08546664
41Acute necrotizing encephalopathy (HP:0006965)3.07593274
42Difficulty running (HP:0009046)2.86108905
43Palmoplantar keratoderma (HP:0000982)2.86079546
44Ragged-red muscle fibers (HP:0003200)2.82020258
45Bradycardia (HP:0001662)2.67165667
46Hepatocellular necrosis (HP:0001404)2.66601194
47Hypoglycemic coma (HP:0001325)2.62647047
48Conjunctival hamartoma (HP:0100780)2.62361649
49Distal lower limb muscle weakness (HP:0009053)2.59851597
50Acute encephalopathy (HP:0006846)2.59437394
51Ketoacidosis (HP:0001993)2.57232425
52Hypoplastic heart (HP:0001961)2.56769697
53Distal lower limb amyotrophy (HP:0008944)2.56677498
54Mitochondrial inheritance (HP:0001427)2.53559253
55Progressive macrocephaly (HP:0004481)2.51762164
56Congenital malformation of the right heart (HP:0011723)2.47342376
57Double outlet right ventricle (HP:0001719)2.47342376
58Difficulty climbing stairs (HP:0003551)2.46296288
59Increased CSF lactate (HP:0002490)2.43850379
60Neck muscle weakness (HP:0000467)2.38276331
61Abnormality of fatty-acid metabolism (HP:0004359)2.34702549
62Exercise intolerance (HP:0003546)2.34465895
63Pheochromocytoma (HP:0002666)2.33819949
64Increased muscle lipid content (HP:0009058)2.33725284
65Cerebral edema (HP:0002181)2.33302587
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30112542
67Dicarboxylic aciduria (HP:0003215)2.30112542
68Neoplasm of the adrenal gland (HP:0100631)2.28713897
69Type 1 muscle fiber predominance (HP:0003803)2.25815319
70Muscle stiffness (HP:0003552)2.24344594
71Areflexia of lower limbs (HP:0002522)2.22211594
72Sudden cardiac death (HP:0001645)2.21280776
73Abnormality of the tricuspid valve (HP:0001702)2.17452671
74Abnormality of the foot musculature (HP:0001436)2.16981225
75Congestive heart failure (HP:0001635)2.14425521
76Limb-girdle muscle atrophy (HP:0003797)2.13497461
77Scapular winging (HP:0003691)2.13056117
78Lactic acidosis (HP:0003128)2.13032265
79Steppage gait (HP:0003376)2.12899857
80Neuroendocrine neoplasm (HP:0100634)2.10554091
81Respiratory failure (HP:0002878)2.09001589
82Increased serum pyruvate (HP:0003542)2.08509074
83Abnormality of glycolysis (HP:0004366)2.08509074
84Increased intramyocellular lipid droplets (HP:0012240)2.06096617
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.05841637
86Increased variability in muscle fiber diameter (HP:0003557)2.05599053
87Hypoplastic left heart (HP:0004383)2.03003633
88Dysmetric saccades (HP:0000641)2.02050257
89Frequent falls (HP:0002359)2.01662597
90Muscular dystrophy (HP:0003560)2.00304451
91Generalized muscle weakness (HP:0003324)1.99751326
92Testicular atrophy (HP:0000029)1.99120477
93Hamartoma of the eye (HP:0010568)1.98538715
94Lower limb amyotrophy (HP:0007210)1.97499293
95Mildly elevated creatine phosphokinase (HP:0008180)1.97047591
96EMG: neuropathic changes (HP:0003445)1.96785404
97Rimmed vacuoles (HP:0003805)1.94094878
98Abnormality of the endocardium (HP:0004306)1.92881770
99Foot dorsiflexor weakness (HP:0009027)1.91776366
100Esophageal neoplasm (HP:0100751)1.90749786
101Neoplasm of head and neck (HP:0012288)1.90749786
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87501172
103Abnormality of alanine metabolism (HP:0010916)1.87501172
104Hyperalaninemia (HP:0003348)1.87501172
105Abnormality of skeletal muscle fiber size (HP:0012084)1.86210603
106Diaphragmatic weakness (HP:0009113)1.83292665
107Preauricular pit (HP:0004467)1.82705137
108Periauricular skin pits (HP:0100277)1.82705137
109Generalized aminoaciduria (HP:0002909)1.81398821
110Patent foramen ovale (HP:0001655)1.79711953
111Ketosis (HP:0001946)1.78897098
112Pulmonary artery stenosis (HP:0004415)1.77900398
113Lipid accumulation in hepatocytes (HP:0006561)1.76278408
114Bulbar palsy (HP:0001283)1.76135582
115Tinnitus (HP:0000360)1.74970753
116Resting tremor (HP:0002322)1.74823224
117Progressive muscle weakness (HP:0003323)1.73092106
118Multiple enchondromatosis (HP:0005701)1.72205953
119Large for gestational age (HP:0001520)1.72042708
120Abnormality of the shoulder girdle musculature (HP:0001435)1.71426461
121Skin pits (HP:0100276)1.70881684
122Gowers sign (HP:0003391)1.70178674
123Hip contracture (HP:0003273)1.68131296
124Abnormal ventriculo-arterial connection (HP:0011563)1.60789701
125Transposition of the great arteries (HP:0001669)1.60789701
126Abnormal connection of the cardiac segments (HP:0011545)1.60789701
127Myopathic facies (HP:0002058)1.58231552
128Waddling gait (HP:0002515)1.48668447
129Proximal amyotrophy (HP:0007126)1.48642765
130Aplasia of the musculature (HP:0100854)1.45652427
131Skin nodule (HP:0200036)1.43835616
132Lymphangioma (HP:0100764)1.42094918
133Toxemia of pregnancy (HP:0100603)1.40067972
134Late onset (HP:0003584)1.39059681
135Maternal diabetes (HP:0009800)1.35717839
136Aneurysm (HP:0002617)1.35624698
137Respiratory insufficiency due to muscle weakness (HP:0002747)1.35028366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.20641656
2OBSCN5.15402067
3MYLK4.88809594
4LMTK23.72198463
5PKN23.52267574
6PHKG23.50320167
7PHKG13.50320167
8PDK33.20337518
9PDK43.20337518
10DMPK3.16011819
11STK243.03678559
12PIK3CA2.63498779
13TRIB32.52019774
14NEK12.33296303
15BCKDK2.29326769
16MUSK2.27344309
17TIE12.15241152
18PDK21.89004871
19ZAK1.64985113
20ILK1.59672930
21STK38L1.56968754
22PINK11.54153486
23EPHA31.52795329
24MARK11.49981687
25CDC42BPA1.43387865
26PAK31.40595351
27GRK71.33371302
28CAMK2D1.25975577
29STK41.25861173
30PRKD11.23760753
31TRPM71.16228397
32ROCK11.13323886
33FLT31.08716000
34WNK41.08137521
35DAPK31.01709458
36MAP3K50.89690952
37MAPK120.88783971
38MAP3K60.85366665
39PIK3CG0.85014947
40MAP3K70.84182268
41PRKAA10.80193387
42MAPKAPK30.78881696
43RIPK10.75756664
44PRKAA20.75696954
45PTK2B0.70549234
46MAPK40.70350900
47KDR0.69503799
48PKN10.69314642
49CAMK40.68722099
50INSRR0.68033075
51MAPK70.65467578
52MAP2K30.65004900
53CAMK10.64231365
54ROCK20.64039903
55PDGFRA0.62389695
56RPS6KC10.60941438
57RPS6KL10.60941438
58STK380.60457532
59MAP3K30.59081305
60CAMK2A0.58210738
61WNK10.57766855
62TGFBR20.53266737
63RPS6KA60.51550653
64CAMK2B0.51346672
65LIMK10.51034174
66PRKACB0.50715946
67NEK90.49537958
68NLK0.49161658
69STK390.47784209
70ITK0.47055224
71MAP2K10.44448051
72PRKD30.43557822
73DDR20.41128683
74PRKCE0.39536252
75PRKACA0.37695252
76KSR20.35895094
77BLK0.35439003
78PRKACG0.34563450
79MAP3K100.32841585
80AKT20.30508780
81CAMK2G0.30476768
82STK110.30068482
83ZAP700.29714976
84EPHB20.29637418
85FGFR40.29537122
86ICK0.27961229
87LATS10.26622727
88MARK30.25917729
89PTK60.24470530
90PRKCH0.24176121
91NME20.24084052
92PDPK10.23735750
93FGFR30.22949531
94RPS6KA10.22918026
95MARK20.22135577
96PRKG20.22074208
97LATS20.21829956
98PDK10.21665933
99DYRK1B0.21234194
100KSR10.20902177
101EPHB10.20347451
102SGK20.20088772
103PRKG10.19952122
104MAPK100.19925791
105LRRK20.19022032
106TESK10.16643797
107PAK20.15873411
108ADRBK10.14958754
109MTOR0.14034340
110SIK10.13957093
111PRKCQ0.12781759
112RET0.12603711
113SGK30.12108030
114STK30.12002790
115RPS6KA20.11770768
116MAPKAPK20.11708084
117RPS6KA30.08653965
118JAK10.08094104
119FER0.08092335
120SGK10.08058798
121TGFBR10.07639787
122FGFR10.07105068
123UHMK10.06314623
124CDK40.06238308

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.17549419
2Cardiac muscle contraction_Homo sapiens_hsa042604.77695206
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.34515187
4Dilated cardiomyopathy_Homo sapiens_hsa054143.96226305
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.91896472
6Parkinsons disease_Homo sapiens_hsa050123.46847291
7Oxidative phosphorylation_Homo sapiens_hsa001903.32031237
8Propanoate metabolism_Homo sapiens_hsa006403.07057125
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95645805
10Fatty acid degradation_Homo sapiens_hsa000712.73800227
11Carbon metabolism_Homo sapiens_hsa012002.60229227
12Alzheimers disease_Homo sapiens_hsa050102.46943322
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.42718026
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23829235
15Huntingtons disease_Homo sapiens_hsa050162.22363679
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08740494
17Fatty acid metabolism_Homo sapiens_hsa012122.06605241
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88634241
19Pyruvate metabolism_Homo sapiens_hsa006201.81403474
20Viral myocarditis_Homo sapiens_hsa054161.69143533
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53680670
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48528143
23Biosynthesis of amino acids_Homo sapiens_hsa012301.32079561
24Fatty acid elongation_Homo sapiens_hsa000621.27203402
25Butanoate metabolism_Homo sapiens_hsa006501.18119923
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07505394
27Glucagon signaling pathway_Homo sapiens_hsa049221.01518568
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98008441
29Insulin resistance_Homo sapiens_hsa049310.95982916
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95844789
31Starch and sucrose metabolism_Homo sapiens_hsa005000.94785184
32PPAR signaling pathway_Homo sapiens_hsa033200.91666948
33HIF-1 signaling pathway_Homo sapiens_hsa040660.86277200
34Adipocytokine signaling pathway_Homo sapiens_hsa049200.84344828
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84222663
36Insulin signaling pathway_Homo sapiens_hsa049100.77847191
37Focal adhesion_Homo sapiens_hsa045100.75787959
38Galactose metabolism_Homo sapiens_hsa000520.74339872
39Lysine degradation_Homo sapiens_hsa003100.70231434
40Tryptophan metabolism_Homo sapiens_hsa003800.68863445
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67757330
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65092304
43Calcium signaling pathway_Homo sapiens_hsa040200.65016845
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.64424002
45Tight junction_Homo sapiens_hsa045300.64361301
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.62415393
47beta-Alanine metabolism_Homo sapiens_hsa004100.62229305
48AMPK signaling pathway_Homo sapiens_hsa041520.57816835
49Fructose and mannose metabolism_Homo sapiens_hsa000510.54968185
50GABAergic synapse_Homo sapiens_hsa047270.54942351
51Oxytocin signaling pathway_Homo sapiens_hsa049210.54523060
52Morphine addiction_Homo sapiens_hsa050320.54069092
53Salivary secretion_Homo sapiens_hsa049700.53846903
54Phenylalanine metabolism_Homo sapiens_hsa003600.53271864
55Type II diabetes mellitus_Homo sapiens_hsa049300.51366419
56Arginine biosynthesis_Homo sapiens_hsa002200.50188612
57Arginine and proline metabolism_Homo sapiens_hsa003300.49931454
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47447617
59Taste transduction_Homo sapiens_hsa047420.45555916
60ECM-receptor interaction_Homo sapiens_hsa045120.45145846
61Adherens junction_Homo sapiens_hsa045200.41677157
62Peroxisome_Homo sapiens_hsa041460.41080175
63Amphetamine addiction_Homo sapiens_hsa050310.40531429
64Linoleic acid metabolism_Homo sapiens_hsa005910.35734338
65cAMP signaling pathway_Homo sapiens_hsa040240.35342794
66Fatty acid biosynthesis_Homo sapiens_hsa000610.34010454
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33658696
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.33479704
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33203153
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32642043
71Melanogenesis_Homo sapiens_hsa049160.32602563
72Regulation of autophagy_Homo sapiens_hsa041400.32521666
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31813273
74Thyroid hormone synthesis_Homo sapiens_hsa049180.30996436
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30300070
76Renin secretion_Homo sapiens_hsa049240.29586129
77Mineral absorption_Homo sapiens_hsa049780.28613758
78Prion diseases_Homo sapiens_hsa050200.28243170
79Amoebiasis_Homo sapiens_hsa051460.27733284
80Protein digestion and absorption_Homo sapiens_hsa049740.27511790
81Metabolic pathways_Homo sapiens_hsa011000.27509825
82Cocaine addiction_Homo sapiens_hsa050300.26164691
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.26029201
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.25859480
85Long-term potentiation_Homo sapiens_hsa047200.24740728
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23572416
87Insulin secretion_Homo sapiens_hsa049110.22860308
88Tyrosine metabolism_Homo sapiens_hsa003500.22502771
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21593599
90Endometrial cancer_Homo sapiens_hsa052130.21285622
91Gastric acid secretion_Homo sapiens_hsa049710.21119393
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.19006157
93Proteoglycans in cancer_Homo sapiens_hsa052050.18366882
94Serotonergic synapse_Homo sapiens_hsa047260.18246253
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16014135
96Circadian entrainment_Homo sapiens_hsa047130.15662305
97Glutamatergic synapse_Homo sapiens_hsa047240.15554840
98Circadian rhythm_Homo sapiens_hsa047100.15397977
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11537156
100Ovarian steroidogenesis_Homo sapiens_hsa049130.11436613
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11139289
102Renal cell carcinoma_Homo sapiens_hsa052110.10657692
103Platelet activation_Homo sapiens_hsa046110.09977121
104Pentose phosphate pathway_Homo sapiens_hsa000300.09454847
105Small cell lung cancer_Homo sapiens_hsa052220.06083408
106mTOR signaling pathway_Homo sapiens_hsa041500.05288971
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.04236462
108Fat digestion and absorption_Homo sapiens_hsa049750.01553836
109Gap junction_Homo sapiens_hsa045400.00829873
110FoxO signaling pathway_Homo sapiens_hsa040680.00826698
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.00795729
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.00466972
113Pancreatic secretion_Homo sapiens_hsa04972-0.0522998
114Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0501934
115Bile secretion_Homo sapiens_hsa04976-0.0467191
116Glycerolipid metabolism_Homo sapiens_hsa00561-0.0459973
117Cholinergic synapse_Homo sapiens_hsa04725-0.0320268
118Notch signaling pathway_Homo sapiens_hsa04330-0.0173820
119PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0151414
120VEGF signaling pathway_Homo sapiens_hsa04370-0.0080608
121Toxoplasmosis_Homo sapiens_hsa05145-0.0048537
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0022445
123GnRH signaling pathway_Homo sapiens_hsa04912-0.0005889

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