POP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.56238503
2nuclear pore complex assembly (GO:0051292)5.42641306
3DNA unwinding involved in DNA replication (GO:0006268)5.14260381
4protein localization to kinetochore (GO:0034501)5.09346204
5folic acid-containing compound biosynthetic process (GO:0009396)4.92141423
6DNA replication initiation (GO:0006270)4.77294483
7IMP biosynthetic process (GO:0006188)4.76082519
8mitotic nuclear envelope disassembly (GO:0007077)4.74738706
9mitotic metaphase plate congression (GO:0007080)4.60287262
10nucleobase biosynthetic process (GO:0046112)4.53698429
11ribosomal small subunit biogenesis (GO:0042274)4.48303635
12membrane disassembly (GO:0030397)4.42675360
13nuclear envelope disassembly (GO:0051081)4.42675360
14DNA strand elongation involved in DNA replication (GO:0006271)4.37719594
15formation of translation preinitiation complex (GO:0001731)4.30359954
16DNA replication-dependent nucleosome organization (GO:0034723)4.30095887
17DNA replication-dependent nucleosome assembly (GO:0006335)4.30095887
18IMP metabolic process (GO:0046040)4.20720765
19pore complex assembly (GO:0046931)4.18322678
20purine nucleobase biosynthetic process (GO:0009113)4.16335514
21DNA strand elongation (GO:0022616)4.14159293
22protein localization to chromosome, centromeric region (GO:0071459)4.09796698
23ribosome assembly (GO:0042255)4.04405351
24maturation of SSU-rRNA (GO:0030490)4.03068366
25DNA replication checkpoint (GO:0000076)3.99824405
26metaphase plate congression (GO:0051310)3.89941793
27telomere maintenance via semi-conservative replication (GO:0032201)3.85515365
28ribosome biogenesis (GO:0042254)3.85307876
29mitotic sister chromatid segregation (GO:0000070)3.84287662
30DNA duplex unwinding (GO:0032508)3.83160029
31DNA geometric change (GO:0032392)3.80886094
32regulation of posttranscriptional gene silencing (GO:0060147)3.80831642
33regulation of gene silencing by miRNA (GO:0060964)3.80831642
34regulation of gene silencing by RNA (GO:0060966)3.80831642
35heterochromatin organization (GO:0070828)3.79268595
36nucleobase-containing small molecule interconversion (GO:0015949)3.71090463
37regulation of spindle organization (GO:0090224)3.69816837
38mitotic chromosome condensation (GO:0007076)3.66232814
39sister chromatid segregation (GO:0000819)3.60754461
40chromatin remodeling at centromere (GO:0031055)3.57440099
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56063841
42positive regulation of chromosome segregation (GO:0051984)3.55455943
43telomere maintenance via recombination (GO:0000722)3.54319104
44establishment of chromosome localization (GO:0051303)3.50038780
45mitotic recombination (GO:0006312)3.49794780
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47872608
47protein K6-linked ubiquitination (GO:0085020)3.45425633
48CENP-A containing nucleosome assembly (GO:0034080)3.43067116
49kinetochore organization (GO:0051383)3.42696170
50regulation of translational termination (GO:0006449)3.40538293
51regulation of mitotic spindle organization (GO:0060236)3.40515098
52attachment of spindle microtubules to kinetochore (GO:0008608)3.36627455
53double-strand break repair via nonhomologous end joining (GO:0006303)3.36605669
54non-recombinational repair (GO:0000726)3.36605669
55nuclear envelope organization (GO:0006998)3.36086357
56regulation of DNA endoreduplication (GO:0032875)3.34052828
57ribonucleoprotein complex biogenesis (GO:0022613)3.33053118
58telomere maintenance via telomere lengthening (GO:0010833)3.31564931
59chromatin assembly (GO:0031497)3.31456194
60DNA replication-independent nucleosome organization (GO:0034724)3.29990376
61DNA replication-independent nucleosome assembly (GO:0006336)3.29990376
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.29309713
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29309713
64regulation of histone H3-K9 methylation (GO:0051570)3.25369720
65rRNA processing (GO:0006364)3.25224262
66ribosomal large subunit biogenesis (GO:0042273)3.24554489
67regulation of helicase activity (GO:0051095)3.24331114
68transcription from mitochondrial promoter (GO:0006390)3.23477667
69regulation of translational fidelity (GO:0006450)3.22968647
70chromatin assembly or disassembly (GO:0006333)3.22246497
71regulation of centriole replication (GO:0046599)3.19764193
72chromosome segregation (GO:0007059)3.17752713
73meiotic chromosome segregation (GO:0045132)3.16117760
74pre-miRNA processing (GO:0031054)3.15545839
75rRNA metabolic process (GO:0016072)3.15058274
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.12805203
77tRNA methylation (GO:0030488)3.11738523
78regulation of centrosome cycle (GO:0046605)3.10385488
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10264044
80cellular component biogenesis (GO:0044085)3.09220155
81rRNA modification (GO:0000154)3.07542317
82DNA conformation change (GO:0071103)3.06619652
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.06460031
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06460031
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06460031
86pseudouridine synthesis (GO:0001522)3.06400577
87spindle checkpoint (GO:0031577)3.05261362
88mitotic sister chromatid cohesion (GO:0007064)3.04737423
89regulation of chromosome segregation (GO:0051983)3.04456057
90transcription-coupled nucleotide-excision repair (GO:0006283)3.03929509
91negative regulation of chromosome segregation (GO:0051985)3.02050073
92translational termination (GO:0006415)3.01690383
93maturation of 5.8S rRNA (GO:0000460)3.00773538
94protein localization to chromosome (GO:0034502)3.00711718
95chromosome condensation (GO:0030261)3.00634923
96viral transcription (GO:0019083)3.00542722
97mitochondrial RNA metabolic process (GO:0000959)2.99029018
98tetrahydrofolate metabolic process (GO:0046653)2.96947674
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96581736
100DNA topological change (GO:0006265)2.96576386
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96465808
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96373644
103histone exchange (GO:0043486)2.96284931
104folic acid metabolic process (GO:0046655)2.95847154
105mitotic spindle checkpoint (GO:0071174)2.95514980
106negative regulation of histone methylation (GO:0031061)2.95255048
107translational initiation (GO:0006413)2.94253226
108regulation of mitochondrial translation (GO:0070129)2.93352697
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93215986
110negative regulation of sister chromatid segregation (GO:0033046)2.93215986
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.93215986
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93215986
113kinetochore assembly (GO:0051382)2.92560488
114spindle assembly checkpoint (GO:0071173)2.92011555
115regulation of sister chromatid cohesion (GO:0007063)2.91524464
116establishment of viral latency (GO:0019043)2.90980865
117translation (GO:0006412)2.90939846
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90873173
119spliceosomal snRNP assembly (GO:0000387)2.90329620
120mRNA transport (GO:0051028)2.88623973
1217-methylguanosine mRNA capping (GO:0006370)2.88398716
122mitotic spindle assembly checkpoint (GO:0007094)2.88280037
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86704781
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86190601
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85190596
126cotranslational protein targeting to membrane (GO:0006613)2.84305171
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84150507
128mismatch repair (GO:0006298)2.83630316
129rRNA methylation (GO:0031167)2.83475257
130establishment of integrated proviral latency (GO:0075713)2.82653557
131negative regulation of ligase activity (GO:0051352)2.81993488
132ribosomal small subunit assembly (GO:0000028)2.81430451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.94436536
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.52070138
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.25277830
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91960667
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30672958
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13082020
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11578745
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84804641
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57435125
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.53228454
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.45787140
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45138152
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38342291
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31126194
15AR_21909140_ChIP-Seq_LNCAP_Human2.30969977
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.26819363
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.20957895
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14605011
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.12217127
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11949383
21XRN2_22483619_ChIP-Seq_HELA_Human2.11584984
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04454373
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01273971
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98362448
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93017588
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91897300
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87540583
28* VDR_23849224_ChIP-Seq_CD4+_Human1.87376606
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86175830
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.81467980
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80669697
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79768693
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77779217
34MYC_22102868_ChIP-Seq_BL_Human1.77614563
35FOXP3_21729870_ChIP-Seq_TREG_Human1.71160742
36DCP1A_22483619_ChIP-Seq_HELA_Human1.67603272
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.64516729
38TTF2_22483619_ChIP-Seq_HELA_Human1.61046623
39GABP_19822575_ChIP-Seq_HepG2_Human1.58149558
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56711143
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55024721
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54961764
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51403325
44KDM5A_27292631_Chip-Seq_BREAST_Human1.50842030
45* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49861960
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49208353
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.46250169
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42431426
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42087609
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40428825
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.36875007
52CIITA_25753668_ChIP-Seq_RAJI_Human1.35006017
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32856340
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32825826
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32331473
56ZNF263_19887448_ChIP-Seq_K562_Human1.32172054
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31702840
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31702840
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31702840
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.31518094
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27721701
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27101904
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25944564
64TFEB_21752829_ChIP-Seq_HELA_Human1.25807890
65* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23546084
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22871854
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22373945
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22177769
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19647774
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18687979
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.17514932
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15641358
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15582571
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15461826
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15130190
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14398100
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14374124
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14159324
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11999121
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11768415
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11732143
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11163080
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10249665
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09169151
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08029415
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08004796
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05892580
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04742655
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04542727
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.03731010
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01882080
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.98549330
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98505197
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97332445
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97251656
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96462615
97* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94904728
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.91796532
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90800474
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90644404
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89034421
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88777919
103* NOTCH1_21737748_ChIP-Seq_TLL_Human0.88565246
104VDR_21846776_ChIP-Seq_THP-1_Human0.87273652
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86447855
106ELF5_23300383_ChIP-Seq_T47D_Human0.85950123
107CHD1_26751641_Chip-Seq_LNCaP_Human0.85853805
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85584974
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85483036
110MYC_18940864_ChIP-ChIP_HL60_Human0.85285120
111* SRF_21415370_ChIP-Seq_HL-1_Mouse0.83083998
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82654407
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81528714
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81340019
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81135775
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79330729
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77780293
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75382082
119* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73151926
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70553749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96980668
2MP0010094_abnormal_chromosome_stability4.66516088
3MP0004957_abnormal_blastocyst_morpholog4.49536214
4MP0003111_abnormal_nucleus_morphology4.45182654
5MP0008057_abnormal_DNA_replication3.99625069
6MP0003077_abnormal_cell_cycle3.92546398
7MP0010352_gastrointestinal_tract_polyps3.09795702
8MP0008058_abnormal_DNA_repair2.97838835
9MP0008007_abnormal_cellular_replicative2.72323914
10MP0003123_paternal_imprinting2.69853268
11MP0001730_embryonic_growth_arrest2.64893136
12MP0008932_abnormal_embryonic_tissue2.59000296
13MP0010307_abnormal_tumor_latency2.57919537
14MP0000350_abnormal_cell_proliferation2.53841349
15MP0005076_abnormal_cell_differentiation2.04042813
16MP0003705_abnormal_hypodermis_morpholog2.03557524
17MP0005380_embryogenesis_phenotype2.03109459
18MP0001672_abnormal_embryogenesis/_devel2.03109459
19MP0001697_abnormal_embryo_size1.93818546
20MP0008877_abnormal_DNA_methylation1.93108139
21MP0002396_abnormal_hematopoietic_system1.91816836
22MP0005408_hypopigmentation1.91233049
23MP0003786_premature_aging1.90739814
24MP0009697_abnormal_copulation1.90222301
25MP0004197_abnormal_fetal_growth/weight/1.86543440
26MP0003984_embryonic_growth_retardation1.82490025
27MP0002009_preneoplasia1.81043190
28MP0002085_abnormal_embryonic_tissue1.80662000
29MP0002088_abnormal_embryonic_growth/wei1.78104620
30MP0002084_abnormal_developmental_patter1.74760514
31MP0002086_abnormal_extraembryonic_tissu1.73792042
32MP0002080_prenatal_lethality1.73689957
33MP0001348_abnormal_lacrimal_gland1.71572572
34MP0010234_abnormal_vibrissa_follicle1.70761707
35MP0003718_maternal_effect1.67528475
36MP0003806_abnormal_nucleotide_metabolis1.65189724
37MP0003121_genomic_imprinting1.57511326
38MP0000490_abnormal_crypts_of1.53659615
39MP0003890_abnormal_embryonic-extraembry1.46727393
40MP0010030_abnormal_orbit_morphology1.45551107
41MP0004808_abnormal_hematopoietic_stem1.38617639
42MP0000579_abnormal_nail_morphology1.38020718
43MP0002019_abnormal_tumor_incidence1.37701319
44MP0000313_abnormal_cell_death1.37338415
45MP0003566_abnormal_cell_adhesion1.35317568
46MP0004233_abnormal_muscle_weight1.28048214
47MP0001293_anophthalmia1.22335722
48MP0003567_abnormal_fetal_cardiomyocyte1.20960394
49MP0006035_abnormal_mitochondrial_morpho1.18836343
50MP0009053_abnormal_anal_canal1.15342779
51MP0003950_abnormal_plasma_membrane1.15288541
52MP0003119_abnormal_digestive_system1.13609828
53MP0000015_abnormal_ear_pigmentation1.12509025
54MP0009250_abnormal_appendicular_skeleto1.10840161
55MP0005023_abnormal_wound_healing1.09373529
56MP0000537_abnormal_urethra_morphology1.09370530
57MP0009672_abnormal_birth_weight1.08646966
58MP0002796_impaired_skin_barrier1.08345769
59MP0002060_abnormal_skin_morphology1.08175320
60MP0009333_abnormal_splenocyte_physiolog1.06813256
61MP0001915_intracranial_hemorrhage1.06801169
62MP0000762_abnormal_tongue_morphology1.03674187
63MP0003755_abnormal_palate_morphology1.02160978
64MP0002938_white_spotting1.00895786
65MP0002210_abnormal_sex_determination0.97118516
66MP0003941_abnormal_skin_development0.96355548
67MP0005621_abnormal_cell_physiology0.96028990
68MP0001849_ear_inflammation0.95591245
69MP0009703_decreased_birth_body0.95539668
70MP0001661_extended_life_span0.95290403
71MP0003186_abnormal_redox_activity0.95218617
72MP0000703_abnormal_thymus_morphology0.94406787
73MP0003453_abnormal_keratinocyte_physiol0.93946674
74MP0004133_heterotaxia0.93835696
75MP0002177_abnormal_outer_ear0.93289210
76MP0005384_cellular_phenotype0.93172331
77MP0001881_abnormal_mammary_gland0.92656421
78MP0003937_abnormal_limbs/digits/tail_de0.91696360
79MP0002111_abnormal_tail_morphology0.90703406
80MP0001216_abnormal_epidermal_layer0.89864484
81MP0005397_hematopoietic_system_phenotyp0.89729175
82MP0001545_abnormal_hematopoietic_system0.89729175
83MP0003315_abnormal_perineum_morphology0.87963915
84MP0005257_abnormal_intraocular_pressure0.87337027
85MP0001145_abnormal_male_reproductive0.87151394
86MP0002653_abnormal_ependyma_morphology0.86918368
87MP0000627_abnormal_mammary_gland0.86141732
88MP0000733_abnormal_muscle_development0.85015555
89MP0002877_abnormal_melanocyte_morpholog0.83795301
90MP0000858_altered_metastatic_potential0.83054165
91MP0000358_abnormal_cell_content/0.80301140
92MP0000372_irregular_coat_pigmentation0.80228168
93MP0002006_tumorigenesis0.77941113
94MP0002092_abnormal_eye_morphology0.77676265
95MP0003763_abnormal_thymus_physiology0.77387649
96MP0000569_abnormal_digit_pigmentation0.77351996
97MP0002398_abnormal_bone_marrow0.77094392
98MP0009379_abnormal_foot_pigmentation0.76996002
99MP0003385_abnormal_body_wall0.76877310
100MP0004264_abnormal_extraembryonic_tissu0.76855195
101MP0001727_abnormal_embryo_implantation0.76074557
102MP0002722_abnormal_immune_system0.75936508
103MP0000432_abnormal_head_morphology0.75447844
104MP0000428_abnormal_craniofacial_morphol0.74692980
105MP0005395_other_phenotype0.74674009
106MP0001119_abnormal_female_reproductive0.74502820
107MP0002697_abnormal_eye_size0.74196261
108MP0005174_abnormal_tail_pigmentation0.73157778
109MP0000653_abnormal_sex_gland0.72536712
110MP0000689_abnormal_spleen_morphology0.72073236
111MP0001186_pigmentation_phenotype0.72050868
112MP0009278_abnormal_bone_marrow0.72023139
113MP0001286_abnormal_eye_development0.69808281
114MP0002095_abnormal_skin_pigmentation0.69578758
115MP0004185_abnormal_adipocyte_glucose0.68888182
116MP0001929_abnormal_gametogenesis0.68756413
117MP0000477_abnormal_intestine_morphology0.68549913
118MP0008770_decreased_survivor_rate0.68421169
119MP0002098_abnormal_vibrissa_morphology0.67602335
120MP0002925_abnormal_cardiovascular_devel0.66626858
121MP0006036_abnormal_mitochondrial_physio0.65436006
122MP0006292_abnormal_olfactory_placode0.65109232
123MP0005197_abnormal_uvea_morphology0.64563846
124MP0003115_abnormal_respiratory_system0.62413082
125MP0000371_diluted_coat_color0.61840261
126MP0003221_abnormal_cardiomyocyte_apopto0.60224591
127MP0000516_abnormal_urinary_system0.60219612
128MP0005367_renal/urinary_system_phenotyp0.60219612
129MP0005623_abnormal_meninges_morphology0.59615645
130MP0002075_abnormal_coat/hair_pigmentati0.59012512
131MP0002429_abnormal_blood_cell0.58816589
132MP0005501_abnormal_skin_physiology0.56768655
133MP0003091_abnormal_cell_migration0.54866039
134MP0003861_abnormal_nervous_system0.54507657
135MP0003936_abnormal_reproductive_system0.54005556
136MP0002160_abnormal_reproductive_system0.53791141
137MP0000750_abnormal_muscle_regeneration0.53537669
138MP0003935_abnormal_craniofacial_develop0.53418335

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.79336742
2Reduced antithrombin III activity (HP:0001976)4.14696509
3Ependymoma (HP:0002888)3.99511511
4Chromsome breakage (HP:0040012)3.97552732
5Type I transferrin isoform profile (HP:0003642)3.86180717
6Selective tooth agenesis (HP:0001592)3.83108670
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78490410
8Medulloblastoma (HP:0002885)3.59059820
9Breast hypoplasia (HP:0003187)3.52450543
10Abnormality of the labia minora (HP:0012880)3.47063968
11Poikiloderma (HP:0001029)3.22482431
12Abnormality of chromosome stability (HP:0003220)3.21435138
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13941720
14Agnosia (HP:0010524)3.13706271
15Colon cancer (HP:0003003)3.11355875
16Rhabdomyosarcoma (HP:0002859)3.05266789
17Reticulocytopenia (HP:0001896)2.99465204
18Patellar aplasia (HP:0006443)2.93607259
19Ectopic kidney (HP:0000086)2.92992029
20Abnormality of placental membranes (HP:0011409)2.91904742
21Amniotic constriction ring (HP:0009775)2.91904742
22Absent radius (HP:0003974)2.88656708
23Impulsivity (HP:0100710)2.86746813
24Carpal bone hypoplasia (HP:0001498)2.86724553
25Abnormality of the astrocytes (HP:0100707)2.85468761
26Astrocytoma (HP:0009592)2.85468761
27Meckel diverticulum (HP:0002245)2.85301405
28Degeneration of anterior horn cells (HP:0002398)2.84743991
29Abnormality of the anterior horn cell (HP:0006802)2.84743991
30Abnormality of the intrinsic pathway (HP:0010989)2.75053136
31Abnormal protein glycosylation (HP:0012346)2.73546041
32Abnormal glycosylation (HP:0012345)2.73546041
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73546041
34Abnormal protein N-linked glycosylation (HP:0012347)2.73546041
35Deviation of the thumb (HP:0009603)2.73030793
36Absent thumb (HP:0009777)2.72011537
37Abnormality of the ileum (HP:0001549)2.71948666
38Aplasia/Hypoplasia of the patella (HP:0006498)2.69950707
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.69797490
40Abnormality of the preputium (HP:0100587)2.69369948
41Absent forearm bone (HP:0003953)2.68393929
42Aplasia involving forearm bones (HP:0009822)2.68393929
43Abnormality of methionine metabolism (HP:0010901)2.65744927
44Proximal placement of thumb (HP:0009623)2.63747259
45Microvesicular hepatic steatosis (HP:0001414)2.61248097
46Hypoplastic pelvis (HP:0008839)2.57817040
47Supernumerary spleens (HP:0009799)2.55936779
48Glioma (HP:0009733)2.54598765
49Myelodysplasia (HP:0002863)2.48357697
50Aplasia/hypoplasia of the humerus (HP:0006507)2.46770970
51Abnormal number of incisors (HP:0011064)2.46597214
52Basal cell carcinoma (HP:0002671)2.45997215
53Neoplasm of striated muscle (HP:0009728)2.43852637
54Abnormalities of placenta or umbilical cord (HP:0001194)2.43076334
55Ridged nail (HP:0001807)2.41713923
56Entropion (HP:0000621)2.41246193
57Hypoplasia of the pons (HP:0012110)2.39484844
58Missing ribs (HP:0000921)2.39215924
59Duodenal stenosis (HP:0100867)2.39182315
60Small intestinal stenosis (HP:0012848)2.39182315
61Rough bone trabeculation (HP:0100670)2.38637407
62Macrocytic anemia (HP:0001972)2.35902151
63Abnormality of DNA repair (HP:0003254)2.33303209
64Neoplasm of the oral cavity (HP:0100649)2.31617692
65Oral leukoplakia (HP:0002745)2.31391846
66Short humerus (HP:0005792)2.30482493
67Abnormality of glycolysis (HP:0004366)2.28803576
68Progressive muscle weakness (HP:0003323)2.27688429
69Abnormal number of erythroid precursors (HP:0012131)2.24935180
70Microglossia (HP:0000171)2.24651947
71Neoplasm of the pancreas (HP:0002894)2.24008035
72Sparse eyelashes (HP:0000653)2.23989234
73Cafe-au-lait spot (HP:0000957)2.20549665
74Trismus (HP:0000211)2.20434956
75Squamous cell carcinoma (HP:0002860)2.18872935
76Increased nuchal translucency (HP:0010880)2.17776183
77Atresia of the external auditory canal (HP:0000413)2.17707973
78Ankyloglossia (HP:0010296)2.16547397
7911 pairs of ribs (HP:0000878)2.16242108
80Esophageal atresia (HP:0002032)2.14944473
81Abnormality of the umbilical cord (HP:0010881)2.14762430
82Horseshoe kidney (HP:0000085)2.14013393
83Abnormal lung lobation (HP:0002101)2.13696828
84Abnormality of the distal phalanges of the toes (HP:0010182)2.12010717
85Premature graying of hair (HP:0002216)2.11068401
86Glossoptosis (HP:0000162)2.10247071
87Increased serum pyruvate (HP:0003542)2.09949809
88Sloping forehead (HP:0000340)2.09274787
89Volvulus (HP:0002580)2.09210615
90Abnormality of the pons (HP:0007361)2.09097447
91Short middle phalanx of the 5th finger (HP:0004220)2.08310717
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08040806
93Abnormal mitochondria in muscle tissue (HP:0008316)2.07192029
94Multiple enchondromatosis (HP:0005701)2.07174999
95Aplasia cutis congenita (HP:0001057)2.07021430
96Amaurosis fugax (HP:0100576)2.06968591
97Cerebral hypomyelination (HP:0006808)2.06228392
98Acute necrotizing encephalopathy (HP:0006965)2.05879222
99Tracheoesophageal fistula (HP:0002575)2.04479490
100Abnormality of the duodenum (HP:0002246)2.04476355
101Choanal atresia (HP:0000453)2.04029862
102Short thumb (HP:0009778)2.03577639
103Cutaneous melanoma (HP:0012056)2.03146294
104Abnormality of the fetal cardiovascular system (HP:0010948)2.02850909
105Abnormal umbilical cord blood vessels (HP:0011403)2.02850909
106Single umbilical artery (HP:0001195)2.02850909
107Thrombocytosis (HP:0001894)2.01588793
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01501788
109Short 4th metacarpal (HP:0010044)2.01501788
110Aplasia/Hypoplasia of the sternum (HP:0006714)2.00530939
111Facial hemangioma (HP:0000329)1.99456499
112Acute encephalopathy (HP:0006846)1.97613170
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97488289
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97488289
115Spinal muscular atrophy (HP:0007269)1.97100171
116Premature ovarian failure (HP:0008209)1.96856949
117Bone marrow hypocellularity (HP:0005528)1.96647647
118Abnormality of the calcaneus (HP:0008364)1.95578572
119Increased hepatocellular lipid droplets (HP:0006565)1.94680218
120Reduced subcutaneous adipose tissue (HP:0003758)1.94194935
121Overlapping toe (HP:0001845)1.90429230
122Prominent nose (HP:0000448)1.89818363
123Slender long bone (HP:0003100)1.88970404
124Biliary tract neoplasm (HP:0100574)1.88921229
125Progressive external ophthalmoplegia (HP:0000590)1.88529507
126Abnormality of the carotid arteries (HP:0005344)1.88502153
127Pelvic girdle muscle weakness (HP:0003749)1.87914298
128Abnormality of pyrimidine metabolism (HP:0004353)1.87137262
129Duplicated collecting system (HP:0000081)1.85131050
130Abnormality of cells of the erythroid lineage (HP:0012130)1.85013246
131Arteriovenous malformation (HP:0100026)1.84933982
132Abnormality of oral frenula (HP:0000190)1.84424466
133Abnormality of abdominal situs (HP:0011620)1.84185593
134Abdominal situs inversus (HP:0003363)1.84185593
135Cerebral edema (HP:0002181)1.83826443
136Gastrointestinal carcinoma (HP:0002672)1.81801454
137Malignant gastrointestinal tract tumors (HP:0006749)1.81801454
138Abnormal trabecular bone morphology (HP:0100671)1.80941588
139Increased serum lactate (HP:0002151)1.80353892
140Pallor (HP:0000980)1.80224777
141Onycholysis (HP:0001806)1.80168641
142Stenosis of the external auditory canal (HP:0000402)1.80062160
143High pitched voice (HP:0001620)1.79540021
144Rib fusion (HP:0000902)1.78440031
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.78164526
146Angiofibromas (HP:0010615)1.76773398
147Adenoma sebaceum (HP:0009720)1.76773398
148Breast aplasia (HP:0100783)1.75446018
149Adrenal hypoplasia (HP:0000835)1.73243537
150Secondary amenorrhea (HP:0000869)1.72847089
151Freckling (HP:0001480)1.72331140
152Vertebral clefting (HP:0008428)1.71700432
153Deep philtrum (HP:0002002)1.71390939
154Nephroblastoma (Wilms tumor) (HP:0002667)1.70890986
155Fragile nails (HP:0001808)1.70660150
156Fused cervical vertebrae (HP:0002949)1.70451896
157Increased intramyocellular lipid droplets (HP:0012240)1.69268067
158Premature rupture of membranes (HP:0001788)1.69035029
159Respiratory difficulties (HP:0002880)1.68418821
160Lipid accumulation in hepatocytes (HP:0006561)1.68219184
161Facial cleft (HP:0002006)1.68200623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.40372777
2WEE13.83402182
3BUB13.62826442
4CDK123.25212568
5NEK22.82694492
6TTK2.78952535
7EIF2AK12.63084132
8TSSK62.53761507
9MST1R2.40368071
10SRPK12.37558742
11EPHA22.16077119
12VRK22.03159536
13PLK12.03111108
14MST42.01218325
15EEF2K1.96680283
16CDK71.95121185
17PASK1.91378518
18NEK11.87305502
19BRSK21.82750967
20PKN21.80932071
21ATR1.75396307
22RPS6KB21.74684211
23STK101.72920196
24MAP3K81.67195661
25AURKB1.66672654
26TLK11.66040547
27MKNK11.65835345
28CDK41.64741614
29SMG11.64022560
30CHEK21.62311870
31PLK31.59997891
32EIF2AK31.51473916
33IRAK31.50597678
34CHEK11.48992095
35NME11.46803751
36MKNK21.45357799
37PLK41.41978150
38TESK21.38047147
39ACVR1B1.37918707
40ALK1.36985374
41RPS6KA41.36591866
42NME21.34976262
43MAP3K101.27253465
44PDK21.22102189
45AURKA1.21389551
46SCYL21.20491368
47STK41.19466094
48DYRK31.17101396
49TAF11.14204573
50ZAK1.10314601
51LATS21.09954164
52LATS11.08254785
53VRK11.07024063
54STK31.05370321
55* ATM1.05252674
56CCNB11.05051565
57* CDK21.03883606
58MELK1.03023972
59PAK41.01807171
60BRD41.01461902
61PIM21.00623116
62TGFBR11.00374534
63PIM10.96096323
64FLT30.95703895
65BRSK10.92890200
66ICK0.89668642
67CDK30.88569775
68STK38L0.83565462
69CDK60.82865885
70MTOR0.78114214
71TTN0.78078952
72CSNK2A20.76155876
73MAP2K30.74767000
74CDK10.74736253
75NEK90.74014964
76TESK10.72615019
77LRRK20.70111067
78CAMK1G0.66221932
79PAK20.64094092
80PAK10.63453815
81ARAF0.61991599
82PTK20.60420918
83CSNK1E0.60063636
84AKT20.57611925
85PRKCI0.56572500
86CSNK2A10.54965578
87TRIB30.52334764
88EIF2AK20.51921816
89PNCK0.50812823
90CLK10.50473137
91CSNK1D0.48840348
92IRAK20.48415763
93MAP3K120.48102793
94CAMK1D0.47776671
95MAP3K140.47496532
96BMX0.47427533
97TRIM280.47413728
98* PRKDC0.45096514
99FGFR10.44021911
100LIMK10.42501966
101CDK80.39505540
102MET0.39086798
103EPHB20.38508791
104STK160.38287683
105RPS6KA50.37785015
106MAPK140.37760045
107GRK60.36435673
108PBK0.33623373
109MAP3K60.32226724
110BRAF0.31651388
111ERBB40.31444270
112MARK30.31436218
113JAK30.31411666
114MAP4K10.30649457
115AKT10.29893394
116ILK0.29292991
117BCKDK0.28962899
118RPS6KB10.28250428
119PTK60.27986009
120MAP3K110.27098410
121CHUK0.25592119
122MAP3K50.25570095
123MAPK10.25296594
124TAOK20.24785829
125CDK90.24466493
126YES10.21076522
127MAP3K90.20551917

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69220131
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.20992623
3Mismatch repair_Homo sapiens_hsa034304.16956218
4One carbon pool by folate_Homo sapiens_hsa006703.56857065
5* RNA transport_Homo sapiens_hsa030133.47847559
6Spliceosome_Homo sapiens_hsa030403.18511474
7Homologous recombination_Homo sapiens_hsa034402.88881100
8RNA polymerase_Homo sapiens_hsa030202.88610154
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.88273190
10Cell cycle_Homo sapiens_hsa041102.86495817
11Nucleotide excision repair_Homo sapiens_hsa034202.76414798
12Base excision repair_Homo sapiens_hsa034102.72795636
13Proteasome_Homo sapiens_hsa030502.38158122
14Ribosome_Homo sapiens_hsa030102.27285449
15Fanconi anemia pathway_Homo sapiens_hsa034602.18084965
16Non-homologous end-joining_Homo sapiens_hsa034502.07113957
17Pyrimidine metabolism_Homo sapiens_hsa002402.04406779
18RNA degradation_Homo sapiens_hsa030182.03024681
19mRNA surveillance pathway_Homo sapiens_hsa030152.02068101
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92300899
21Systemic lupus erythematosus_Homo sapiens_hsa053221.78180003
22Basal transcription factors_Homo sapiens_hsa030221.76113329
23p53 signaling pathway_Homo sapiens_hsa041151.73300670
24Protein export_Homo sapiens_hsa030601.69945721
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47071480
26Viral carcinogenesis_Homo sapiens_hsa052031.29073862
27Epstein-Barr virus infection_Homo sapiens_hsa051691.22294269
28Oxidative phosphorylation_Homo sapiens_hsa001901.22235604
29Parkinsons disease_Homo sapiens_hsa050121.18771010
30Huntingtons disease_Homo sapiens_hsa050161.14723952
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13325573
32Biosynthesis of amino acids_Homo sapiens_hsa012301.05974059
33Selenocompound metabolism_Homo sapiens_hsa004501.05926747
34MicroRNAs in cancer_Homo sapiens_hsa052061.03003003
35Purine metabolism_Homo sapiens_hsa002301.02042985
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.97795445
37Herpes simplex infection_Homo sapiens_hsa051680.97569773
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.95751042
39Pyruvate metabolism_Homo sapiens_hsa006200.94370628
40Oocyte meiosis_Homo sapiens_hsa041140.91893927
41Antigen processing and presentation_Homo sapiens_hsa046120.90990703
42Steroid biosynthesis_Homo sapiens_hsa001000.88310060
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87196018
44HTLV-I infection_Homo sapiens_hsa051660.86354953
45Small cell lung cancer_Homo sapiens_hsa052220.84474652
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80018383
47Thyroid cancer_Homo sapiens_hsa052160.78734491
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77797206
49Alzheimers disease_Homo sapiens_hsa050100.73812156
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70035772
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67425938
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66450902
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65514313
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63986037
55Alcoholism_Homo sapiens_hsa050340.62606500
56TGF-beta signaling pathway_Homo sapiens_hsa043500.62196273
57Legionellosis_Homo sapiens_hsa051340.61434924
58Hippo signaling pathway_Homo sapiens_hsa043900.61048206
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59353442
60Pentose phosphate pathway_Homo sapiens_hsa000300.58733184
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.57563540
62Adherens junction_Homo sapiens_hsa045200.56584658
63Apoptosis_Homo sapiens_hsa042100.56268403
64Vitamin B6 metabolism_Homo sapiens_hsa007500.55172572
65Chronic myeloid leukemia_Homo sapiens_hsa052200.53972617
66Colorectal cancer_Homo sapiens_hsa052100.52328347
67Folate biosynthesis_Homo sapiens_hsa007900.50085777
68Basal cell carcinoma_Homo sapiens_hsa052170.50009982
69Bladder cancer_Homo sapiens_hsa052190.49771668
70Viral myocarditis_Homo sapiens_hsa054160.49524195
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.46598392
72Sulfur metabolism_Homo sapiens_hsa009200.46201307
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46041233
74Metabolic pathways_Homo sapiens_hsa011000.44779949
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44301470
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43465050
77mTOR signaling pathway_Homo sapiens_hsa041500.43266649
78Notch signaling pathway_Homo sapiens_hsa043300.42111059
79Hepatitis B_Homo sapiens_hsa051610.41774049
80Carbon metabolism_Homo sapiens_hsa012000.40830026
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40625197
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40344116
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.40335486
84Lysine degradation_Homo sapiens_hsa003100.40132790
85Shigellosis_Homo sapiens_hsa051310.39679093
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37102445
87HIF-1 signaling pathway_Homo sapiens_hsa040660.36902783
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36097834
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35871901
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35322333
91Measles_Homo sapiens_hsa051620.34112477
92Sulfur relay system_Homo sapiens_hsa041220.33932843
93Pathways in cancer_Homo sapiens_hsa052000.33188008
94Glutathione metabolism_Homo sapiens_hsa004800.30808540
95Prostate cancer_Homo sapiens_hsa052150.30621100
96Galactose metabolism_Homo sapiens_hsa000520.30453868
97Proteoglycans in cancer_Homo sapiens_hsa052050.28094925
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27773464
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25657017
100Influenza A_Homo sapiens_hsa051640.24704395
101Fatty acid elongation_Homo sapiens_hsa000620.24018902
102Hedgehog signaling pathway_Homo sapiens_hsa043400.23659249
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22838010
104Fatty acid biosynthesis_Homo sapiens_hsa000610.22760899
105Acute myeloid leukemia_Homo sapiens_hsa052210.22431638
106Melanoma_Homo sapiens_hsa052180.22127003
107Non-small cell lung cancer_Homo sapiens_hsa052230.22006314
108Allograft rejection_Homo sapiens_hsa053300.20740859
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20520290
110Tight junction_Homo sapiens_hsa045300.19938794
111Pancreatic cancer_Homo sapiens_hsa052120.19583391
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17958007
113Fructose and mannose metabolism_Homo sapiens_hsa000510.17444411
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15971796
115Type I diabetes mellitus_Homo sapiens_hsa049400.15070556
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14404333
117Renin-angiotensin system_Homo sapiens_hsa046140.13371093
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13216819
119N-Glycan biosynthesis_Homo sapiens_hsa005100.12950725
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12830609
121Wnt signaling pathway_Homo sapiens_hsa043100.12555522
122Primary immunodeficiency_Homo sapiens_hsa053400.12350208
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.11585423
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11516368

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