PON1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.54336942
2omega-hydroxylase P450 pathway (GO:0097267)8.07116858
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51411518
4L-phenylalanine catabolic process (GO:0006559)7.51411518
5L-phenylalanine metabolic process (GO:0006558)7.17389268
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.17389268
7aromatic amino acid family catabolic process (GO:0009074)6.76474578
8drug metabolic process (GO:0017144)6.36957022
9oxidative demethylation (GO:0070989)6.31029005
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24331403
11tryptophan catabolic process (GO:0006569)6.09382316
12indole-containing compound catabolic process (GO:0042436)6.09382316
13indolalkylamine catabolic process (GO:0046218)6.09382316
14phenylpropanoid metabolic process (GO:0009698)6.02534648
15bile acid biosynthetic process (GO:0006699)6.00636873
16kynurenine metabolic process (GO:0070189)5.96489930
17glyoxylate metabolic process (GO:0046487)5.73648775
18tryptophan metabolic process (GO:0006568)5.73505461
19urea cycle (GO:0000050)5.61276976
20urea metabolic process (GO:0019627)5.61276976
21high-density lipoprotein particle remodeling (GO:0034375)5.59766710
22negative regulation of fibrinolysis (GO:0051918)5.52186294
23sulfur amino acid catabolic process (GO:0000098)5.49618391
24cysteine metabolic process (GO:0006534)5.48269405
25alpha-linolenic acid metabolic process (GO:0036109)5.46585632
26regulation of fibrinolysis (GO:0051917)5.35984298
27ethanol metabolic process (GO:0006067)5.32708278
28peptidyl-glutamic acid carboxylation (GO:0017187)5.29637725
29protein carboxylation (GO:0018214)5.29637725
30complement activation, alternative pathway (GO:0006957)5.24249792
31regulation of protein activation cascade (GO:2000257)5.17422758
32nitrogen cycle metabolic process (GO:0071941)5.16010072
33cellular glucuronidation (GO:0052695)5.15167514
34bile acid metabolic process (GO:0008206)5.14680808
35serine family amino acid catabolic process (GO:0009071)5.06900979
36regulation of plasminogen activation (GO:0010755)5.06701615
37aromatic amino acid family metabolic process (GO:0009072)4.91501736
38regulation of cholesterol esterification (GO:0010872)4.90639626
39reverse cholesterol transport (GO:0043691)4.82906652
40regulation of complement activation (GO:0030449)4.82327453
41tyrosine metabolic process (GO:0006570)4.80516812
42negative regulation of blood coagulation (GO:0030195)4.79801990
43negative regulation of hemostasis (GO:1900047)4.79801990
44homocysteine metabolic process (GO:0050667)4.79615649
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78455416
46plasma lipoprotein particle remodeling (GO:0034369)4.74382024
47protein-lipid complex remodeling (GO:0034368)4.74382024
48macromolecular complex remodeling (GO:0034367)4.74382024
49regulation of triglyceride catabolic process (GO:0010896)4.73195665
50uronic acid metabolic process (GO:0006063)4.72711353
51glucuronate metabolic process (GO:0019585)4.72711353
52amino-acid betaine metabolic process (GO:0006577)4.69161746
53alkaloid metabolic process (GO:0009820)4.67687987
54negative regulation of protein activation cascade (GO:2000258)4.64921404
55alpha-amino acid catabolic process (GO:1901606)4.60103982
56S-adenosylmethionine metabolic process (GO:0046500)4.58037313
57acylglycerol homeostasis (GO:0055090)4.55102440
58triglyceride homeostasis (GO:0070328)4.55102440
59phospholipid efflux (GO:0033700)4.52457700
60lysine metabolic process (GO:0006553)4.49208539
61lysine catabolic process (GO:0006554)4.49208539
62negative regulation of cholesterol transport (GO:0032375)4.49151931
63negative regulation of sterol transport (GO:0032372)4.49151931
64regulation of humoral immune response (GO:0002920)4.48776773
65hormone catabolic process (GO:0042447)4.47897193
66bile acid and bile salt transport (GO:0015721)4.42058162
67negative regulation of wound healing (GO:0061045)4.38900975
68glycine metabolic process (GO:0006544)4.36466318
69negative regulation of coagulation (GO:0050819)4.35544396
70benzene-containing compound metabolic process (GO:0042537)4.34768683
71acute-phase response (GO:0006953)4.33953520
72cellular ketone body metabolic process (GO:0046950)4.32702483
73indolalkylamine metabolic process (GO:0006586)4.31438367
74imidazole-containing compound metabolic process (GO:0052803)4.30753629
75plasma lipoprotein particle clearance (GO:0034381)4.30536470
76coenzyme catabolic process (GO:0009109)4.27744091
77cellular biogenic amine catabolic process (GO:0042402)4.25156339
78amine catabolic process (GO:0009310)4.25156339
79cellular amino acid catabolic process (GO:0009063)4.24574552
80ethanol oxidation (GO:0006069)4.22625686
81glutamate metabolic process (GO:0006536)4.20258977
82cholesterol efflux (GO:0033344)4.18767487
83serine family amino acid metabolic process (GO:0009069)4.17865870
84aldehyde catabolic process (GO:0046185)4.16639937
85low-density lipoprotein particle remodeling (GO:0034374)4.08718409
86drug catabolic process (GO:0042737)4.06046268
87negative regulation of complement activation (GO:0045916)4.04496195
88negative regulation of lipase activity (GO:0060192)4.01797587
89dicarboxylic acid biosynthetic process (GO:0043650)4.01553557
90cellular modified amino acid catabolic process (GO:0042219)4.01105322
91serine family amino acid biosynthetic process (GO:0009070)3.99790015
92positive regulation of blood coagulation (GO:0030194)3.98943822
93positive regulation of hemostasis (GO:1900048)3.98943822
94arginine metabolic process (GO:0006525)3.96066077
95steroid catabolic process (GO:0006706)3.94256820
96fibrinolysis (GO:0042730)3.94008740
97heme transport (GO:0015886)3.93614521
98plasma lipoprotein particle assembly (GO:0034377)3.92958892
99cytolysis (GO:0019835)3.89359564
100opsonization (GO:0008228)3.87441372
101response to nitrosative stress (GO:0051409)3.81768257
102flavonoid metabolic process (GO:0009812)3.78677838
103regulation of bile acid biosynthetic process (GO:0070857)3.76674689
104blood coagulation, intrinsic pathway (GO:0007597)3.76545613
105ketone body metabolic process (GO:1902224)3.75014580
106cofactor catabolic process (GO:0051187)3.74402216
107positive regulation of lipid catabolic process (GO:0050996)3.73790640
108* carboxylic acid catabolic process (GO:0046395)3.73430502
109* organic acid catabolic process (GO:0016054)3.73430502
110phospholipid homeostasis (GO:0055091)3.72800602
111very-low-density lipoprotein particle assembly (GO:0034379)3.72344831
112short-chain fatty acid metabolic process (GO:0046459)3.70612363
113xenobiotic metabolic process (GO:0006805)3.70156100
114cholesterol homeostasis (GO:0042632)3.69131848
115positive regulation of coagulation (GO:0050820)3.68268308
116complement activation, classical pathway (GO:0006958)3.67053658
117complement activation (GO:0006956)3.65257947
118NAD biosynthetic process (GO:0009435)3.65086735
119protein activation cascade (GO:0072376)3.65070115
120positive regulation of triglyceride lipase activity (GO:0061365)3.64745127
121positive regulation of lipoprotein lipase activity (GO:0051006)3.64745127
122sterol homeostasis (GO:0055092)3.62771795
123nicotinamide nucleotide biosynthetic process (GO:0019359)3.62682396
124pyridine nucleotide biosynthetic process (GO:0019363)3.62682396
125exogenous drug catabolic process (GO:0042738)3.62667149
126acetyl-CoA metabolic process (GO:0006084)3.62037210
127polyketide metabolic process (GO:0030638)3.61665224
128doxorubicin metabolic process (GO:0044598)3.61665224
129daunorubicin metabolic process (GO:0044597)3.61665224
130disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.51124406
131killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.51124406
132fat-soluble vitamin biosynthetic process (GO:0042362)3.47847047
133regulation of lipoprotein particle clearance (GO:0010984)3.45816294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30125136
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.08895912
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03155956
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46970111
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32598300
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07201248
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71116334
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02784936
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.96505108
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09506774
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8461947
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93236582
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89876407
14CLOCK_20551151_ChIP-Seq_293T_Human1.60823948
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.59551802
16HTT_18923047_ChIP-ChIP_STHdh_Human1.51289527
17GATA1_22025678_ChIP-Seq_K562_Human1.42953531
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.37794883
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31265070
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27614109
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19449584
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.15924107
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14155221
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.12478776
25CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11397366
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10743871
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09516405
28IRF1_19129219_ChIP-ChIP_H3396_Human1.06755911
29HNFA_21074721_ChIP-Seq_CACO-2_Human1.06357668
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05841931
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03869020
32PHF8_20622853_ChIP-Seq_HELA_Human1.03306854
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00682297
34EZH2_27294783_Chip-Seq_NPCs_Mouse0.98890969
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97696800
36GATA6_21074721_ChIP-Seq_CACO-2_Human0.93965263
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93497636
38SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92304774
39NFYA_21822215_ChIP-Seq_K562_Human0.92072032
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91763979
41RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90542917
42GATA4_25053715_ChIP-Seq_YYC3_Human0.86525870
43IRF8_22096565_ChIP-ChIP_GC-B_Human0.86405472
44PIAS1_25552417_ChIP-Seq_VCAP_Human0.85349831
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85211940
46AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84127751
47SOX2_21211035_ChIP-Seq_LN229_Human0.82710138
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80213604
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79717993
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79625413
51CRX_20693478_ChIP-Seq_RETINA_Mouse0.79558840
52ESR2_21235772_ChIP-Seq_MCF-7_Human0.78735587
53ZNF263_19887448_ChIP-Seq_K562_Human0.78594938
54CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78389091
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77197704
56NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77197704
57* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77115293
58POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76721393
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75182521
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74821701
61* ER_23166858_ChIP-Seq_MCF-7_Human0.74049959
62KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73937032
63TP53_18474530_ChIP-ChIP_U2OS_Human0.73904410
64ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73873421
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73696887
66OCT4_21477851_ChIP-Seq_ESCs_Mouse0.73181523
67ETV1_20927104_ChIP-Seq_GIST48_Human0.72964152
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72768488
69RARA_24833708_ChIP-Seq_LIVER_Mouse0.71672611
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71131665
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70846883
72RUNX1_27457419_Chip-Seq_LIVER_Mouse0.70747015
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70227465
74GBX2_23144817_ChIP-Seq_PC3_Human0.70087321
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68903047
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.67109738
77* ESR1_20079471_ChIP-ChIP_T-47D_Human0.67018645
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66828115
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.66683513
80OCT4_18555785_Chip-Seq_ESCs_Mouse0.66242664
81RBPJ_21746931_ChIP-Seq_IB4_Human0.66120203
82NFYB_21822215_ChIP-Seq_K562_Human0.66101958
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.65998492
84ESRRB_18555785_Chip-Seq_ESCs_Mouse0.65992197
85SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65110112
86SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64631996
87NCOR_22424771_ChIP-Seq_293T_Human0.62629563
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62249065
89RAC3_21632823_ChIP-Seq_H3396_Human0.61992968
90RARB_24833708_ChIP-Seq_LIVER_Mouse0.60863468
91* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.60803532
92PU1_27457419_Chip-Seq_LIVER_Mouse0.59994130
93CBP_20019798_ChIP-Seq_JUKART_Human0.59774115
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.59774115
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58903303
96IGF1R_20145208_ChIP-Seq_DFB_Human0.58005955
97MYC_19829295_ChIP-Seq_ESCs_Human0.57020013
98NANOG_19829295_ChIP-Seq_ESCs_Human0.56953986
99SOX2_19829295_ChIP-Seq_ESCs_Human0.56953986
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56882391
101KLF4_18555785_Chip-Seq_ESCs_Mouse0.56535858
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.56434105
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.56107886
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.55984193
105* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55896973
106* FOXA1_25552417_ChIP-Seq_VCAP_Human0.55845409
107ZFX_18555785_Chip-Seq_ESCs_Mouse0.55364532
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54595920
109CEBPB_22108803_ChIP-Seq_LS180_Human0.54447028
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.54221227
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.54214062
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53006810
113TAF15_26573619_Chip-Seq_HEK293_Human0.52786155
114EGR1_19032775_ChIP-ChIP_M12_Human0.52026351
115MYC_19915707_ChIP-ChIP_AK7_Human0.51742256
116AR_20517297_ChIP-Seq_VCAP_Human0.51532558
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51006475
118CBP_21632823_ChIP-Seq_H3396_Human0.50101790
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.49382821
120STAT1_17558387_ChIP-Seq_HELA_Human0.49184186
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.48383549
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.47888850
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47740395
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47436458
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46479897
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44701732
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44581806
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43922319
129LXR_22292898_ChIP-Seq_THP-1_Human0.43108990
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42670583
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.42594570
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42455190
133P53_21459846_ChIP-Seq_SAOS-2_Human0.42233977
134SOX2_20726797_ChIP-Seq_SW620_Human0.41713767
135GATA6_25053715_ChIP-Seq_YYC3_Human0.40912974
136GATA1_19941826_ChIP-Seq_K562_Human0.40789671
137GATA2_19941826_ChIP-Seq_K562_Human0.40287770
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.39400373
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37815838
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37668539
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.37506142
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37472618
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36201914
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.35645389
145CDX2_22108803_ChIP-Seq_LS180_Human0.35539785
146* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.35515970
147ERG_20517297_ChIP-Seq_VCAP_Human0.35052041
148TAF2_19829295_ChIP-Seq_ESCs_Human0.34952894
149* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.34864977
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.33741904
151* BCAT_22108803_ChIP-Seq_LS180_Human0.33632850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27043122
2MP0005360_urolithiasis7.44942927
3MP0005085_abnormal_gallbladder_physiolo6.49199455
4MP0005365_abnormal_bile_salt6.25445135
5MP0008875_abnormal_xenobiotic_pharmacok5.65922107
6MP0003806_abnormal_nucleotide_metabolis4.23733682
7MP0003252_abnormal_bile_duct3.86238736
8* MP0010329_abnormal_lipoprotein_level3.47739903
9MP0009840_abnormal_foam_cell3.21597574
10MP0005083_abnormal_biliary_tract3.03969226
11MP0003195_calcinosis2.82861703
12MP0005332_abnormal_amino_acid2.75521876
13MP0001666_abnormal_nutrient_absorption2.54774007
14MP0003191_abnormal_cellular_cholesterol2.19891441
15MP0004019_abnormal_vitamin_homeostasis2.15099495
16MP0000609_abnormal_liver_physiology2.12610070
17* MP0002118_abnormal_lipid_homeostasis2.05343572
18MP0002138_abnormal_hepatobiliary_system1.94546126
19MP0003868_abnormal_feces_composition1.85701082
20MP0005319_abnormal_enzyme/_coenzyme1.82417806
21MP0001764_abnormal_homeostasis1.67827290
22MP0009697_abnormal_copulation1.58895374
23* MP0005584_abnormal_enzyme/coenzyme_acti1.46176006
24MP0005451_abnormal_body_composition1.44819494
25MP0003011_delayed_dark_adaptation1.39057577
26MP0009643_abnormal_urine_homeostasis1.21606511
27MP0005647_abnormal_sex_gland1.21559258
28MP0003656_abnormal_erythrocyte_physiolo1.20185111
29* MP0003186_abnormal_redox_activity1.17963759
30MP0000598_abnormal_liver_morphology1.15773019
31MP0002254_reproductive_system_inflammat1.11657080
32MP0005187_abnormal_penis_morphology1.06771229
33MP0003705_abnormal_hypodermis_morpholog1.04876238
34MP0009764_decreased_sensitivity_to1.04701452
35MP0000604_amyloidosis1.00206663
36MP0009763_increased_sensitivity_to0.99990020
37MP0010368_abnormal_lymphatic_system0.97910924
38MP0005408_hypopigmentation0.96780585
39MP0005636_abnormal_mineral_homeostasis0.86490099
40MP0008469_abnormal_protein_level0.84369468
41* MP0009642_abnormal_blood_homeostasis0.83419134
42MP0005376_homeostasis/metabolism_phenot0.82398119
43MP0009053_abnormal_anal_canal0.80941676
44MP0001915_intracranial_hemorrhage0.80599265
45MP0009765_abnormal_xenobiotic_induced0.78158156
46MP0003879_abnormal_hair_cell0.76586969
47MP0006036_abnormal_mitochondrial_physio0.75684519
48MP0005670_abnormal_white_adipose0.74718420
49MP0002078_abnormal_glucose_homeostasis0.74694233
50MP0003690_abnormal_glial_cell0.73894524
51MP0002876_abnormal_thyroid_physiology0.72419149
52MP0005266_abnormal_metabolism0.71611883
53MP0005220_abnormal_exocrine_pancreas0.70564530
54MP0005334_abnormal_fat_pad0.69228318
55MP0002971_abnormal_brown_adipose0.68164711
56MP0005084_abnormal_gallbladder_morpholo0.68019818
57MP0005535_abnormal_body_temperature0.66193755
58MP0002282_abnormal_trachea_morphology0.62278026
59MP0004130_abnormal_muscle_cell0.61448374
60MP0001756_abnormal_urination0.58881986
61MP0000639_abnormal_adrenal_gland0.58657544
62MP0004782_abnormal_surfactant_physiolog0.55758533
63MP0001661_extended_life_span0.55055173
64MP0003329_amyloid_beta_deposits0.54623611
65MP0005448_abnormal_energy_balance0.50010066
66MP0005464_abnormal_platelet_physiology0.48195917
67MP0005395_other_phenotype0.47214740
68MP0005248_abnormal_Harderian_gland0.46839732
69MP0002822_catalepsy0.46780011
70MP0006035_abnormal_mitochondrial_morpho0.46308327
71MP0002249_abnormal_larynx_morphology0.46250205
72MP0008874_decreased_physiological_sensi0.46070382
73MP0008872_abnormal_physiological_respon0.44540904
74MP0005058_abnormal_lysosome_morphology0.44278944
75MP0002928_abnormal_bile_duct0.44059046
76MP0003638_abnormal_response/metabolism_0.43844386
77MP0002136_abnormal_kidney_physiology0.43613015
78MP0003075_altered_response_to0.41922893
79MP0003724_increased_susceptibility_to0.41669790
80MP0002132_abnormal_respiratory_system0.41561984
81MP0000566_synostosis0.40794209
82MP0003718_maternal_effect0.40308420
83MP0005166_decreased_susceptibility_to0.39538034
84MP0010386_abnormal_urinary_bladder0.39226173
85MP0009384_cardiac_valve_regurgitation0.39048000
86MP0001984_abnormal_olfaction0.38772676
87MP0003953_abnormal_hormone_level0.38769319
88MP0004381_abnormal_hair_follicle0.38567223
89MP0003436_decreased_susceptibility_to0.36810347
90* MP0008873_increased_physiological_sensi0.36003355
91MP0009785_altered_susceptibility_to0.35212107
92MP0009115_abnormal_fat_cell0.33537395
93MP0000579_abnormal_nail_morphology0.33438490
94MP0002168_other_aberrant_phenotype0.33377569
95MP0004883_abnormal_blood_vessel0.32829561
96MP0002837_dystrophic_cardiac_calcinosis0.32581559
97MP0009672_abnormal_birth_weight0.32136120
98MP0002796_impaired_skin_barrier0.32102182
99MP0005666_abnormal_adipose_tissue0.30812583
100MP0006082_CNS_inflammation0.30057504
101MP0002090_abnormal_vision0.29966572
102MP0000230_abnormal_systemic_arterial0.29843970
103MP0005023_abnormal_wound_healing0.28731533
104MP0005164_abnormal_response_to0.28031270
105MP0003959_abnormal_lean_body0.28012576
106MP0001243_abnormal_dermal_layer0.27103622
107MP0002332_abnormal_exercise_endurance0.26612045
108MP0002970_abnormal_white_adipose0.26229088
109MP0001881_abnormal_mammary_gland0.26084713
110MP0002060_abnormal_skin_morphology0.25709030
111MP0005197_abnormal_uvea_morphology0.25459669
112MP0001853_heart_inflammation0.25310410
113MP0004142_abnormal_muscle_tone0.24811532
114MP0001845_abnormal_inflammatory_respons0.24323491
115MP0001986_abnormal_taste_sensitivity0.24152383
116* MP0000249_abnormal_blood_vessel0.23293468
117MP0001440_abnormal_grooming_behavior0.21630119
118MP0000467_abnormal_esophagus_morphology0.20443311
119MP0003633_abnormal_nervous_system0.20024865
120MP0002089_abnormal_postnatal_growth/wei0.19964684
121MP0001944_abnormal_pancreas_morphology0.18488373
122MP0005167_abnormal_blood-brain_barrier0.15869555
123MP0003631_nervous_system_phenotype0.14887052

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47652826
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.43509816
3Intrahepatic cholestasis (HP:0001406)7.39850522
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69934324
5Prolonged partial thromboplastin time (HP:0003645)6.59086394
6Hypobetalipoproteinemia (HP:0003563)6.48786082
7Xanthomatosis (HP:0000991)6.29541653
8Hyperlipoproteinemia (HP:0010980)5.62811810
9Complement deficiency (HP:0004431)5.24930153
10Hypolipoproteinemia (HP:0010981)4.85951957
11Joint hemorrhage (HP:0005261)4.79990531
12Hyperammonemia (HP:0001987)4.61505556
13Epidermoid cyst (HP:0200040)4.57693366
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45221912
15Hyperglycinemia (HP:0002154)4.43872127
16Abnormality of the common coagulation pathway (HP:0010990)4.42838222
17Abnormality of methionine metabolism (HP:0010901)4.39894997
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.26674255
19Hypoalphalipoproteinemia (HP:0003233)4.25318982
20Ketosis (HP:0001946)4.19365204
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18524468
22Fat malabsorption (HP:0002630)4.18380313
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13862425
24Hyperglycinuria (HP:0003108)4.02804084
25Abnormality of glycine metabolism (HP:0010895)3.95093347
26Abnormality of serine family amino acid metabolism (HP:0010894)3.95093347
27Abnormality of complement system (HP:0005339)3.84667897
28Abnormality of pyrimidine metabolism (HP:0004353)3.82733960
29Conjugated hyperbilirubinemia (HP:0002908)3.79576826
30Hypoglycemic coma (HP:0001325)3.78068955
31Hypercholesterolemia (HP:0003124)3.75313467
32Abnormality of the intrinsic pathway (HP:0010989)3.73308107
33Hyperbilirubinemia (HP:0002904)3.39471417
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35841568
35Abnormality of fatty-acid metabolism (HP:0004359)3.33682753
36Reduced antithrombin III activity (HP:0001976)3.22586085
37Steatorrhea (HP:0002570)3.19660680
38Delayed CNS myelination (HP:0002188)3.13925861
39Osteomalacia (HP:0002749)3.12080733
40Hepatocellular carcinoma (HP:0001402)3.08995567
41Abnormality of serum amino acid levels (HP:0003112)3.07706355
42Abnormality of nucleobase metabolism (HP:0010932)3.02969144
43Myocardial infarction (HP:0001658)2.98928095
44Ketoacidosis (HP:0001993)2.96186182
45Spontaneous abortion (HP:0005268)2.92415883
46Hypochromic microcytic anemia (HP:0004840)2.89050967
47Metabolic acidosis (HP:0001942)2.76137467
48Skin nodule (HP:0200036)2.74960290
49Fair hair (HP:0002286)2.67869327
50Systemic lupus erythematosus (HP:0002725)2.67021171
51Abnormality of purine metabolism (HP:0004352)2.63086736
52Lethargy (HP:0001254)2.62127109
53Vascular calcification (HP:0004934)2.58183119
54Dicarboxylic aciduria (HP:0003215)2.55465233
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55465233
56Acanthocytosis (HP:0001927)2.55103856
57Pulmonary embolism (HP:0002204)2.49798693
58Neonatal hypoglycemia (HP:0001998)2.46120196
59Abnormal gallbladder morphology (HP:0012437)2.45572770
60Spastic diplegia (HP:0001264)2.43888891
61Hyperphosphaturia (HP:0003109)2.43628613
62Glomerulonephritis (HP:0000099)2.43063643
63Gout (HP:0001997)2.39987986
64Mitral stenosis (HP:0001718)2.39347579
65Cerebral edema (HP:0002181)2.39002550
66Purpura (HP:0000979)2.38550105
67Cholelithiasis (HP:0001081)2.36186158
68Hypoglycemic seizures (HP:0002173)2.35590307
69Amyloidosis (HP:0011034)2.34888591
70Irritability (HP:0000737)2.32736262
71Cholecystitis (HP:0001082)2.31620840
72Abnormal gallbladder physiology (HP:0012438)2.31620840
73Neonatal onset (HP:0003623)2.28980723
74Cardiovascular calcification (HP:0011915)2.28407717
75Esophageal varix (HP:0002040)2.27339898
76Arthropathy (HP:0003040)2.24799061
77Abnormality of urine glucose concentration (HP:0011016)2.24413589
78Glycosuria (HP:0003076)2.24413589
79Recurrent gram-negative bacterial infections (HP:0005420)2.23506896
80Malnutrition (HP:0004395)2.23147553
81Brushfield spots (HP:0001088)2.14669403
82Gingival bleeding (HP:0000225)2.14321853
83Bile duct proliferation (HP:0001408)2.14169606
84Abnormal biliary tract physiology (HP:0012439)2.14169606
85Menorrhagia (HP:0000132)2.13844910
86Pancreatitis (HP:0001733)2.12948397
87Elevated alkaline phosphatase (HP:0003155)2.11854738
88Sensorimotor neuropathy (HP:0007141)2.09775046
89Enlarged kidneys (HP:0000105)2.08622167
90Renal cortical cysts (HP:0000803)2.05360887
91Thrombophlebitis (HP:0004418)2.04409026
92Opisthotonus (HP:0002179)2.04365064
93Generalized aminoaciduria (HP:0002909)2.04333035
94Vomiting (HP:0002013)2.03772362
95Poikilocytosis (HP:0004447)2.00049369
96Late onset (HP:0003584)1.99007902
97Abnormality of the gallbladder (HP:0005264)1.98881521
98Abnormality of the Achilles tendon (HP:0005109)1.97145268
99Rickets (HP:0002748)1.95725552
100Abnormal urine phosphate concentration (HP:0012599)1.93972241
101Abnormal cartilage morphology (HP:0002763)1.93409328
102Abnormality of alkaline phosphatase activity (HP:0004379)1.92239887
103Hemorrhage of the eye (HP:0011885)1.91797579
104Abnormality of proline metabolism (HP:0010907)1.87256773
105Hydroxyprolinuria (HP:0003080)1.87256773
106Hyperinsulinemic hypoglycemia (HP:0000825)1.86552833
107Hypophosphatemic rickets (HP:0004912)1.86519112
108Generalized hypopigmentation of hair (HP:0011358)1.86248457
109Abnormality of iron homeostasis (HP:0011031)1.82033944
110Elevated hepatic transaminases (HP:0002910)1.81601503
111Alkalosis (HP:0001948)1.81202431
112Abnormality of transition element cation homeostasis (HP:0011030)1.79828947
113Abnormal enzyme/coenzyme activity (HP:0012379)1.78665702
114Abnormality of vitamin metabolism (HP:0100508)1.76540570
115Nephritis (HP:0000123)1.76001124
116Status epilepticus (HP:0002133)1.75711352
117Gangrene (HP:0100758)1.74874447
118Increased serum ferritin (HP:0003281)1.73566840
119Atrioventricular block (HP:0001678)1.72985910
120Proximal tubulopathy (HP:0000114)1.71638065
121Cerebral palsy (HP:0100021)1.70770520
122Bifid scrotum (HP:0000048)1.64662471
123Retinal atrophy (HP:0001105)1.61495708
124Joint swelling (HP:0001386)1.59867159
125Blue irides (HP:0000635)1.52813124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.07457916
2FGFR44.45708365
3SIK14.39728430
4ERN14.00269213
5INSRR2.99543929
6ERBB42.83710020
7TAOK32.78842873
8NTRK32.47742346
9MAP2K42.30519305
10PKN22.24917257
11MST1R2.24744763
12MAP3K122.05692224
13FRK1.99116711
14FLT31.81908122
15MAPK111.77513934
16DAPK21.75605537
17LATS11.72137197
18PIK3CG1.70602500
19TYK21.70468852
20WNK31.67889660
21TRIB31.63007761
22ABL21.45120280
23FGFR21.37858760
24CASK1.36743938
25PTK61.35649476
26NEK91.33506063
27PRKG11.31701060
28PRKACA1.31003709
29TNK21.26742603
30MAP3K31.25247549
31PINK11.25184070
32KDR1.20513558
33JAK21.19800550
34MAP3K71.17921850
35MUSK1.14918170
36MAP3K101.14708704
37MAP2K31.12250671
38MYLK1.11828916
39MAPK151.08512493
40CSNK1D1.08467727
41ERBB21.08089024
42ARAF1.07773477
43PRKAA21.05289600
44MAP3K141.04442849
45JAK11.02626320
46MAPK41.00128006
47GRK60.96796023
48CAMKK20.92410210
49TBK10.92144007
50EPHB10.91884913
51CDK60.90908968
52PRKCZ0.89781592
53EPHA30.89574722
54MET0.88162192
55PDK20.86278445
56STK38L0.85950818
57ACVR1B0.85328888
58TIE10.80765599
59PRKCB0.80548754
60PRPF4B0.79578791
61PBK0.79536742
62SGK10.79340284
63CAMK2G0.76394127
64PRKACB0.74328897
65RPS6KA30.74122653
66SGK30.73910176
67STK160.73395137
68MAP2K60.71832815
69PRKACG0.70620192
70MAPK120.70249694
71NLK0.69872245
72MAP3K110.69413409
73PRKCE0.68563271
74GSK3A0.68052898
75CSK0.67360896
76CSNK1G10.66665745
77FGFR30.65368772
78MAPK70.65353352
79SGK20.64622560
80DYRK1B0.64355123
81CSNK1E0.64189480
82CSNK1A10.64070866
83CAMK1D0.63853541
84PRKAA10.59169908
85RIPK10.57746203
86CSNK2A10.57507516
87MAP2K10.57165007
88IRAK30.55984412
89PDPK10.55759047
90DYRK20.54879827
91IKBKE0.54795551
92MAP3K90.54749427
93EIF2AK10.54460736
94CAMKK10.53883982
95CSF1R0.53095254
96CSNK2A20.53066452
97SRC0.53059427
98TGFBR20.52175210
99PTK20.51577118
100GRK10.48654543
101MAP3K20.48629393
102CSNK1G30.48271163
103PRKCQ0.48216988
104SCYL20.48057110
105PIK3CA0.47355195
106MAP3K10.46789165
107SGK2230.46695171
108SGK4940.46695171
109CSNK1G20.46421226
110BLK0.46274740
111CSNK1A1L0.46069732
112MAP3K60.45918069
113IGF1R0.44868014
114MAP3K40.42855745
115PAK30.42470214
116MAP3K50.41434402
117TAOK20.41387588
118MAP2K20.40657997
119RET0.40360511
120FER0.39602381
121MAP2K70.39235086
122PRKCG0.38469323
123ZAP700.36473556
124NUAK10.35848859
125EPHA40.34817856
126CAMK40.34135580
127PDK40.34061838
128PDK30.34061838
129CDK40.33045914
130BMPR1B0.32552644
131PDK10.32220517
132EGFR0.30948074
133IRAK20.30947732
134MTOR0.30492857
135IRAK10.30476184
136PKN10.30149087
137PRKCA0.26448848
138ABL10.25157802

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45964947
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.65602517
3Nitrogen metabolism_Homo sapiens_hsa009103.46426211
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26794908
5Arginine biosynthesis_Homo sapiens_hsa002202.95173317
6Complement and coagulation cascades_Homo sapiens_hsa046102.65879962
7Tryptophan metabolism_Homo sapiens_hsa003802.62297485
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62119396
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58717077
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51153735
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46629223
12Fatty acid degradation_Homo sapiens_hsa000712.41821036
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36573455
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31094660
15Butanoate metabolism_Homo sapiens_hsa006502.19361838
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17001805
17Chemical carcinogenesis_Homo sapiens_hsa052042.15203320
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.11059522
19Peroxisome_Homo sapiens_hsa041462.04805134
20Caffeine metabolism_Homo sapiens_hsa002321.93573928
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.91626724
22Histidine metabolism_Homo sapiens_hsa003401.88636751
23Propanoate metabolism_Homo sapiens_hsa006401.87287545
24Retinol metabolism_Homo sapiens_hsa008301.85094511
25PPAR signaling pathway_Homo sapiens_hsa033201.80867192
26Fatty acid metabolism_Homo sapiens_hsa012121.73376924
27beta-Alanine metabolism_Homo sapiens_hsa004101.71810613
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68355148
29Staphylococcus aureus infection_Homo sapiens_hsa051501.68005239
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64508881
31Selenocompound metabolism_Homo sapiens_hsa004501.61481171
32Sulfur metabolism_Homo sapiens_hsa009201.55083916
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54529784
34Phenylalanine metabolism_Homo sapiens_hsa003601.54388634
35Bile secretion_Homo sapiens_hsa049761.45804064
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45456070
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41896280
38Tyrosine metabolism_Homo sapiens_hsa003501.41304164
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40225257
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.30333250
41Pyruvate metabolism_Homo sapiens_hsa006201.28146813
42Fatty acid elongation_Homo sapiens_hsa000621.25503052
43ABC transporters_Homo sapiens_hsa020101.25200813
44Steroid biosynthesis_Homo sapiens_hsa001001.17262772
45Folate biosynthesis_Homo sapiens_hsa007901.15802671
46Biosynthesis of amino acids_Homo sapiens_hsa012301.12703897
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10462643
48Fat digestion and absorption_Homo sapiens_hsa049751.07716657
49Sulfur relay system_Homo sapiens_hsa041221.06695528
50Carbon metabolism_Homo sapiens_hsa012001.06632991
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05462239
52Arginine and proline metabolism_Homo sapiens_hsa003300.94404518
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.92797373
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.91710582
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89952645
56Vitamin digestion and absorption_Homo sapiens_hsa049770.83594289
57Vitamin B6 metabolism_Homo sapiens_hsa007500.80586900
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79173946
59Lysine degradation_Homo sapiens_hsa003100.76010743
60One carbon pool by folate_Homo sapiens_hsa006700.74599176
61Glutathione metabolism_Homo sapiens_hsa004800.73905253
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72307630
63Glycerolipid metabolism_Homo sapiens_hsa005610.64051734
64Pentose phosphate pathway_Homo sapiens_hsa000300.56695487
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51454671
66* Metabolic pathways_Homo sapiens_hsa011000.44806309
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41321061
68Prion diseases_Homo sapiens_hsa050200.34718832
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34002708
70Galactose metabolism_Homo sapiens_hsa000520.29785916
71Linoleic acid metabolism_Homo sapiens_hsa005910.22971458
72Insulin resistance_Homo sapiens_hsa049310.22278908
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20658206
74Fructose and mannose metabolism_Homo sapiens_hsa000510.20608277
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.18932317
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14261365
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.11174604
78Glucagon signaling pathway_Homo sapiens_hsa049220.07357690
79Serotonergic synapse_Homo sapiens_hsa047260.06437428
80Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2539725
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2465388
82Pertussis_Homo sapiens_hsa05133-0.2426393
83Amoebiasis_Homo sapiens_hsa05146-0.2411660
84Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2371840
85Ether lipid metabolism_Homo sapiens_hsa00565-0.2346473
86N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2329684
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2320422
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2216730
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2171859
90Circadian rhythm_Homo sapiens_hsa04710-0.2155259
91Renin-angiotensin system_Homo sapiens_hsa04614-0.2148408
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1954444
93Sphingolipid metabolism_Homo sapiens_hsa00600-0.1865693
94Type II diabetes mellitus_Homo sapiens_hsa04930-0.1793352
95Hepatitis C_Homo sapiens_hsa05160-0.1749245
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1747843
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1737958
98Regulation of autophagy_Homo sapiens_hsa04140-0.1649359
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1448718
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1335240
101African trypanosomiasis_Homo sapiens_hsa05143-0.1294408
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1186429
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1058598
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1050101
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0697978
106Mineral absorption_Homo sapiens_hsa04978-0.0603954
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0574594
108Other glycan degradation_Homo sapiens_hsa00511-0.0339283
109AMPK signaling pathway_Homo sapiens_hsa04152-0.0050381

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