POMK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.54563668
2synaptic vesicle exocytosis (GO:0016079)5.49651407
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.24870505
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08544077
5neurotransmitter-gated ion channel clustering (GO:0072578)5.04467646
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.01456971
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.00151492
8glutamate secretion (GO:0014047)4.92782834
9response to pheromone (GO:0019236)4.79625533
10behavioral response to nicotine (GO:0035095)4.74412997
11protein localization to synapse (GO:0035418)4.71178363
12regulation of glutamate receptor signaling pathway (GO:1900449)4.70664212
13neuron cell-cell adhesion (GO:0007158)4.62292302
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50622767
15regulation of synaptic vesicle exocytosis (GO:2000300)4.49475975
16postsynaptic membrane organization (GO:0001941)4.35903422
17DNA replication-dependent nucleosome organization (GO:0034723)4.26781054
18DNA replication-dependent nucleosome assembly (GO:0006335)4.26781054
19cerebellar Purkinje cell layer development (GO:0021680)4.22982667
20negative regulation of cytosolic calcium ion concentration (GO:0051481)4.17488543
21positive regulation of synapse maturation (GO:0090129)4.16715776
22synaptic vesicle maturation (GO:0016188)4.15406379
23regulation of synaptic vesicle transport (GO:1902803)4.05202541
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03926288
25transferrin transport (GO:0033572)3.98819346
26startle response (GO:0001964)3.92726544
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.87703147
28regulation of translation, ncRNA-mediated (GO:0045974)3.87703147
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.87703147
30neurotransmitter secretion (GO:0007269)3.86658961
31synaptic vesicle endocytosis (GO:0048488)3.86168913
32striatum development (GO:0021756)3.85522015
33negative regulation of dendrite development (GO:2000171)3.83680284
34glutamate receptor signaling pathway (GO:0007215)3.79197001
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.78178388
36long-term synaptic potentiation (GO:0060291)3.77852889
37presynaptic membrane assembly (GO:0097105)3.74722513
38regulation of hippo signaling (GO:0035330)3.72980819
39regulation of neuronal synaptic plasticity (GO:0048168)3.71577792
40atrial cardiac muscle cell action potential (GO:0086014)3.69482298
41trivalent inorganic cation transport (GO:0072512)3.66725909
42ferric iron transport (GO:0015682)3.66725909
43regulation of synapse structural plasticity (GO:0051823)3.64709488
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64208999
45synaptic transmission, glutamatergic (GO:0035249)3.62448694
46fucose catabolic process (GO:0019317)3.62279338
47L-fucose metabolic process (GO:0042354)3.62279338
48L-fucose catabolic process (GO:0042355)3.62279338
49rRNA catabolic process (GO:0016075)3.60645061
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.60619344
51locomotory exploration behavior (GO:0035641)3.60606759
52response to auditory stimulus (GO:0010996)3.60471422
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54861842
54piRNA metabolic process (GO:0034587)3.54325443
55neuronal action potential propagation (GO:0019227)3.52987668
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51625584
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.49461661
58ncRNA catabolic process (GO:0034661)3.49455542
59neuron-neuron synaptic transmission (GO:0007270)3.48193668
60ATP hydrolysis coupled proton transport (GO:0015991)3.41079361
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.41079361
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40428794
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40094557
64layer formation in cerebral cortex (GO:0021819)3.36712907
65behavioral response to ethanol (GO:0048149)3.36169624
66regulation of postsynaptic membrane potential (GO:0060078)3.35671740
67presynaptic membrane organization (GO:0097090)3.33849012
68positive regulation of neurotransmitter secretion (GO:0001956)3.28771243
69protein K11-linked deubiquitination (GO:0035871)3.27978924
70neural tube formation (GO:0001841)3.26679777
71regulation of neurotransmitter secretion (GO:0046928)3.25336229
72cerebellar granule cell differentiation (GO:0021707)3.25238410
73regulation of synaptic plasticity (GO:0048167)3.22488844
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22121959
75establishment of synaptic vesicle localization (GO:0097480)3.21719493
76synaptic vesicle transport (GO:0048489)3.21719493
77axonal fasciculation (GO:0007413)3.21344000
78regulation of synapse maturation (GO:0090128)3.20025718
79response to histamine (GO:0034776)3.17620262
80retinal rod cell development (GO:0046548)3.17154901
81exploration behavior (GO:0035640)3.17150506
82auditory behavior (GO:0031223)3.16728804
83nuclear pore organization (GO:0006999)3.15892901
84positive regulation of synapse assembly (GO:0051965)3.12317363
85neuron recognition (GO:0008038)3.11646123
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08218839
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07408763
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07213354
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06921316
90DNA deamination (GO:0045006)3.05855540
91phagosome maturation (GO:0090382)3.05345472
92mitochondrial genome maintenance (GO:0000002)3.03923706
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03769474
94vesicle docking involved in exocytosis (GO:0006904)3.03144055
95dorsal/ventral axis specification (GO:0009950)3.02653321
96mechanosensory behavior (GO:0007638)3.02411088
97positive regulation of synaptic transmission (GO:0050806)3.01883331
98microtubule anchoring (GO:0034453)3.00450479
99kidney morphogenesis (GO:0060993)3.00114819
100developmental pigmentation (GO:0048066)2.98776202
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98748820
102neurotransmitter transport (GO:0006836)2.98326088
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97563647
104pyrimidine nucleobase catabolic process (GO:0006208)2.96997739
105serotonin receptor signaling pathway (GO:0007210)2.96341339
106cytoplasmic mRNA processing body assembly (GO:0033962)2.95913645
107DNA strand renaturation (GO:0000733)2.95529973
108positive regulation of neurotransmitter transport (GO:0051590)2.95330580
109negative regulation of dendrite morphogenesis (GO:0050774)2.95268832
110peptidyl-threonine dephosphorylation (GO:0035970)2.95257146
111adult feeding behavior (GO:0008343)2.93654042
112positive regulation of membrane potential (GO:0045838)2.92711880
113regulation of pigment cell differentiation (GO:0050932)2.92710637
114replication fork processing (GO:0031297)2.92595897
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90519409
116regulation of neurotransmitter transport (GO:0051588)2.86599460
117gene silencing by RNA (GO:0031047)2.86017232
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.84452567
119meiotic cell cycle (GO:0051321)2.83911043
120establishment of protein localization to Golgi (GO:0072600)2.83732688
121nuclear pore complex assembly (GO:0051292)2.83422679
122protein polyglutamylation (GO:0018095)2.81630103
123synapse assembly (GO:0007416)2.81412734
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.80256850
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80256850
126regulation of inositol phosphate biosynthetic process (GO:0010919)2.79869422
127proline transport (GO:0015824)2.78189558
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77296185
129learning (GO:0007612)2.76395949
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.75990884
131innervation (GO:0060384)2.75734897
132regulation of synaptic transmission (GO:0050804)2.73566011
133cornea development in camera-type eye (GO:0061303)2.73551404
134melanin biosynthetic process (GO:0042438)2.73456381
135behavioral fear response (GO:0001662)2.73431206
136behavioral defense response (GO:0002209)2.73431206
137translesion synthesis (GO:0019985)2.73319671
138regulation of synapse assembly (GO:0051963)2.73311440
139membrane depolarization (GO:0051899)2.72831561
140meiotic chromosome segregation (GO:0045132)2.72691679
141DNA double-strand break processing (GO:0000729)2.72188112
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.71849012
143retinal cone cell development (GO:0046549)2.71807470
144regulation of glutamate secretion (GO:0014048)2.70762345
145maturation of 5.8S rRNA (GO:0000460)2.68162539
146regulation of telomere maintenance (GO:0032204)2.66818614
147synapsis (GO:0007129)2.64189358
148interkinetic nuclear migration (GO:0022027)2.62477763
149DNA-dependent DNA replication (GO:0006261)2.60789186
150nonmotile primary cilium assembly (GO:0035058)2.60579939
151protein targeting to Golgi (GO:0000042)2.58490491
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58199351
153regulation of mitotic spindle checkpoint (GO:1903504)2.58199351
154regulation of hexokinase activity (GO:1903299)2.57197803
155regulation of glucokinase activity (GO:0033131)2.57197803
156reciprocal DNA recombination (GO:0035825)2.56490733
157reciprocal meiotic recombination (GO:0007131)2.56490733
158regulation of gene silencing by miRNA (GO:0060964)2.55681131
159regulation of gene silencing by RNA (GO:0060966)2.55681131
160regulation of posttranscriptional gene silencing (GO:0060147)2.55681131
161regulation of acrosome reaction (GO:0060046)2.54874455
162maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51943673
163regulation of mesoderm development (GO:2000380)2.51157276
164epithelial cilium movement (GO:0003351)2.50146985
165recombinational repair (GO:0000725)2.47263921
166histone mRNA catabolic process (GO:0071044)2.46217191
167replicative senescence (GO:0090399)2.45731834
168double-strand break repair via homologous recombination (GO:0000724)2.45632539
169protein K6-linked ubiquitination (GO:0085020)2.45572692
170pyrimidine dimer repair (GO:0006290)2.44828022
171protein K48-linked deubiquitination (GO:0071108)2.44254401
172pore complex assembly (GO:0046931)2.44221195
173DNA demethylation (GO:0080111)2.43445061
174cilium morphogenesis (GO:0060271)2.42850176
175regulation of centriole replication (GO:0046599)2.42736134
176pseudouridine synthesis (GO:0001522)2.41671183
177regulation of meiosis I (GO:0060631)2.41422319
178regulation of DNA endoreduplication (GO:0032875)2.40253100
179tryptophan metabolic process (GO:0006568)2.40218180
180indole-containing compound catabolic process (GO:0042436)2.38849468
181indolalkylamine catabolic process (GO:0046218)2.38849468
182tryptophan catabolic process (GO:0006569)2.38849468
183protein localization to microtubule cytoskeleton (GO:0072698)2.38829396
184cAMP catabolic process (GO:0006198)2.38576567
185protein prenylation (GO:0018342)2.38528227
186prenylation (GO:0097354)2.38528227
187indolalkylamine metabolic process (GO:0006586)2.38258399
188kynurenine metabolic process (GO:0070189)2.38166595
189somatic diversification of immunoglobulins (GO:0016445)2.38123428
190somatic recombination of immunoglobulin gene segments (GO:0016447)2.35258912
191nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.34414973
192DNA methylation involved in gamete generation (GO:0043046)2.32049431
193resolution of meiotic recombination intermediates (GO:0000712)2.31678963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.63532070
2GBX2_23144817_ChIP-Seq_PC3_Human5.25444161
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.77065465
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.62341829
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.31733983
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12375249
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.98536352
8TAF15_26573619_Chip-Seq_HEK293_Human2.83142402
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75567992
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.66825969
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65337908
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64806200
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56706296
14REST_21632747_ChIP-Seq_MESCs_Mouse2.56001992
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50097436
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.49334736
17VDR_22108803_ChIP-Seq_LS180_Human2.41411274
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.34027690
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31944045
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26464272
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.22458341
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21105717
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20329545
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20061978
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20061978
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18190214
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17176657
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10697602
29E2F7_22180533_ChIP-Seq_HELA_Human2.10358051
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09497526
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09116948
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.04055315
33MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02774166
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02661917
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97325626
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.94340865
37AR_21572438_ChIP-Seq_LNCaP_Human1.91956264
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91016129
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90806189
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90155164
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89514195
42DROSHA_22980978_ChIP-Seq_HELA_Human1.86399546
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80077764
44P300_19829295_ChIP-Seq_ESCs_Human1.78267453
45IRF1_19129219_ChIP-ChIP_H3396_Human1.77010158
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.75553722
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75389368
48FUS_26573619_Chip-Seq_HEK293_Human1.75389304
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74127577
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74127577
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.73245204
52SMAD4_21799915_ChIP-Seq_A2780_Human1.71644051
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66692927
54ER_23166858_ChIP-Seq_MCF-7_Human1.66035485
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66021029
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64358132
57CBP_20019798_ChIP-Seq_JUKART_Human1.63562264
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63562264
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56396583
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55903131
61GATA1_22025678_ChIP-Seq_K562_Human1.55298352
62JUN_21703547_ChIP-Seq_K562_Human1.54455094
63AR_25329375_ChIP-Seq_VCAP_Human1.51956170
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48242064
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47321266
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47011186
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45160925
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44920708
69ELK1_19687146_ChIP-ChIP_HELA_Human1.44868840
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44626134
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39786692
72IGF1R_20145208_ChIP-Seq_DFB_Human1.38866735
73ZNF274_21170338_ChIP-Seq_K562_Hela1.35358857
74MYC_18940864_ChIP-ChIP_HL60_Human1.34816721
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34644138
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.34049422
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33667342
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33287625
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33071346
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31253233
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29520049
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29295517
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28542641
84STAT3_23295773_ChIP-Seq_U87_Human1.26001762
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25895621
86RNF2_27304074_Chip-Seq_NSC_Mouse1.25480429
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.24966754
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.24933250
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24551180
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22712606
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.21555532
92EWS_26573619_Chip-Seq_HEK293_Human1.20990936
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20565892
94TP53_16413492_ChIP-PET_HCT116_Human1.17834032
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17710622
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.17195975
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16960804
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15807517
99TP53_18474530_ChIP-ChIP_U2OS_Human1.14333445
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14318822
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.13517996
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.13172070
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.13054006
104SOX9_26525672_Chip-Seq_HEART_Mouse1.12726886
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06897311
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.06072404
107TCF4_22108803_ChIP-Seq_LS180_Human1.05131692
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.04974589
109AR_19668381_ChIP-Seq_PC3_Human1.03959788
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03394934
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02940990
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.02582282
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02401082
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02145613
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.02104746
116SOX2_19829295_ChIP-Seq_ESCs_Human1.01084290
117NANOG_19829295_ChIP-Seq_ESCs_Human1.01084290
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00622161
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99786851
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99663958
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99441607
122VDR_23849224_ChIP-Seq_CD4+_Human0.99278517
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.99253288
124EST1_17652178_ChIP-ChIP_JURKAT_Human0.99222298
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98809400
126TCF4_23295773_ChIP-Seq_U87_Human0.98443731
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97826734
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97606944
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97239442
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96323916
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96236352
132P53_22387025_ChIP-Seq_ESCs_Mouse0.96142621
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95287165
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95087469
135KDM2B_26808549_Chip-Seq_REH_Human0.94981016
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.94899407
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94648162
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.94179022
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.93768409
140RUNX2_22187159_ChIP-Seq_PCA_Human0.93575647
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93488663
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93094414
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91068142
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89192249
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88335343
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.86153042
147ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84513353
148BCAT_22108803_ChIP-Seq_LS180_Human0.84476716
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83653595
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.83119044
151ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81385059
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80761195
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79031852
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78904491
155TP53_22573176_ChIP-Seq_HFKS_Human0.78859109
156AHR_22903824_ChIP-Seq_MCF-7_Human0.78745424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25235213
2MP0003880_abnormal_central_pattern3.97962157
3MP0002736_abnormal_nociception_after3.91763102
4MP0001968_abnormal_touch/_nociception3.68949303
5MP0003635_abnormal_synaptic_transmissio3.67899436
6MP0008057_abnormal_DNA_replication3.23767167
7MP0002063_abnormal_learning/memory/cond3.09916601
8MP0002064_seizures3.02497348
9MP0008877_abnormal_DNA_methylation2.96460998
10MP0009745_abnormal_behavioral_response2.90869192
11MP0003646_muscle_fatigue2.68957076
12MP0001188_hyperpigmentation2.57462387
13MP0002572_abnormal_emotion/affect_behav2.56028043
14MP0004270_analgesia2.53427897
15MP0001984_abnormal_olfaction2.43906101
16MP0002735_abnormal_chemical_nociception2.40073117
17MP0003890_abnormal_embryonic-extraembry2.29844849
18MP0002234_abnormal_pharynx_morphology2.22471544
19MP0009046_muscle_twitch2.21145452
20MP0005646_abnormal_pituitary_gland2.20510403
21MP0004147_increased_porphyrin_level2.17879471
22MP0006276_abnormal_autonomic_nervous2.16252146
23MP0002734_abnormal_mechanical_nocicepti2.12458811
24MP0003718_maternal_effect2.11794935
25MP0003122_maternal_imprinting2.09029230
26MP0008058_abnormal_DNA_repair2.08545105
27MP0002272_abnormal_nervous_system2.00794694
28MP0002067_abnormal_sensory_capabilities1.95121012
29MP0000778_abnormal_nervous_system1.94199602
30MP0005171_absent_coat_pigmentation1.91277253
31MP0004043_abnormal_pH_regulation1.91089715
32MP0002733_abnormal_thermal_nociception1.90200392
33MP0002184_abnormal_innervation1.86301020
34MP0002653_abnormal_ependyma_morphology1.78885375
35MP0001970_abnormal_pain_threshold1.78617086
36MP0003787_abnormal_imprinting1.77221728
37MP0001501_abnormal_sleep_pattern1.77114499
38MP0001440_abnormal_grooming_behavior1.75671184
39MP0001529_abnormal_vocalization1.74705123
40MP0000015_abnormal_ear_pigmentation1.73016942
41MP0003879_abnormal_hair_cell1.71119183
42MP0002557_abnormal_social/conspecific_i1.70385488
43MP0001486_abnormal_startle_reflex1.68859885
44MP0001502_abnormal_circadian_rhythm1.66388928
45MP0004858_abnormal_nervous_system1.65654686
46MP0003172_abnormal_lysosome_physiology1.65328407
47MP0010094_abnormal_chromosome_stability1.64181633
48MP0002909_abnormal_adrenal_gland1.63320894
49MP0005167_abnormal_blood-brain_barrier1.62892913
50MP0005058_abnormal_lysosome_morphology1.62584265
51MP0006292_abnormal_olfactory_placode1.59994794
52MP0003937_abnormal_limbs/digits/tail_de1.55229882
53MP0004811_abnormal_neuron_physiology1.54193643
54MP0010386_abnormal_urinary_bladder1.51163002
55MP0003329_amyloid_beta_deposits1.50034992
56MP0006072_abnormal_retinal_apoptosis1.49233666
57MP0002009_preneoplasia1.48882518
58MP0000955_abnormal_spinal_cord1.43580534
59MP0000427_abnormal_hair_cycle1.42760281
60MP0008569_lethality_at_weaning1.36370320
61MP0003183_abnormal_peptide_metabolism1.32910154
62MP0002822_catalepsy1.31404999
63MP0001986_abnormal_taste_sensitivity1.31394688
64MP0002938_white_spotting1.31335382
65MP0000383_abnormal_hair_follicle1.31173911
66MP0008004_abnormal_stomach_pH1.30011985
67MP0005409_darkened_coat_color1.28691256
68MP0001293_anophthalmia1.27441485
69MP0005187_abnormal_penis_morphology1.26907544
70MP0002882_abnormal_neuron_morphology1.25916425
71MP0003950_abnormal_plasma_membrane1.25251519
72MP0000569_abnormal_digit_pigmentation1.24997112
73MP0002066_abnormal_motor_capabilities/c1.23191102
74MP0003136_yellow_coat_color1.23069535
75MP0003119_abnormal_digestive_system1.22963618
76MP0005394_taste/olfaction_phenotype1.22424408
77MP0005499_abnormal_olfactory_system1.22424408
78MP0004233_abnormal_muscle_weight1.21876054
79MP0003941_abnormal_skin_development1.19414187
80MP0002837_dystrophic_cardiac_calcinosis1.18596354
81MP0004133_heterotaxia1.18457403
82MP0004142_abnormal_muscle_tone1.17726742
83MP0005623_abnormal_meninges_morphology1.15010424
84MP0005551_abnormal_eye_electrophysiolog1.14713212
85MP0003121_genomic_imprinting1.12373720
86MP0005391_vision/eye_phenotype1.11771978
87MP0005174_abnormal_tail_pigmentation1.10500467
88MP0003195_calcinosis1.08878035
89MP0002876_abnormal_thyroid_physiology1.08224374
90MP0002751_abnormal_autonomic_nervous1.07231545
91MP0005645_abnormal_hypothalamus_physiol1.07230179
92MP0009780_abnormal_chondrocyte_physiolo1.06527815
93MP0005386_behavior/neurological_phenoty1.03583524
94MP0004924_abnormal_behavior1.03583524
95MP0000631_abnormal_neuroendocrine_gland1.00866708
96MP0008789_abnormal_olfactory_epithelium1.00078235
97MP0005195_abnormal_posterior_eye0.98109737
98MP0003633_abnormal_nervous_system0.97646580
99MP0002152_abnormal_brain_morphology0.97425997
100MP0004782_abnormal_surfactant_physiolog0.95706908
101MP0000647_abnormal_sebaceous_gland0.94490320
102MP0003077_abnormal_cell_cycle0.94471386
103MP0002638_abnormal_pupillary_reflex0.93955219
104MP0001324_abnormal_eye_pigmentation0.93484013
105MP0001905_abnormal_dopamine_level0.93276822
106MP0001286_abnormal_eye_development0.93168913
107MP0002928_abnormal_bile_duct0.92979440
108MP0010678_abnormal_skin_adnexa0.90859226
109MP0002090_abnormal_vision0.90667991
110MP0003283_abnormal_digestive_organ0.90017126
111MP0001929_abnormal_gametogenesis0.90009565
112MP0008872_abnormal_physiological_respon0.89795385
113MP0002233_abnormal_nose_morphology0.88797870
114MP0009379_abnormal_foot_pigmentation0.88698323
115MP0003861_abnormal_nervous_system0.87954994
116MP0000604_amyloidosis0.86512625
117MP0003111_abnormal_nucleus_morphology0.86083039
118MP0006035_abnormal_mitochondrial_morpho0.84542915
119MP0008961_abnormal_basal_metabolism0.84352608
120MP0003631_nervous_system_phenotype0.84056473
121MP0000372_irregular_coat_pigmentation0.82665054
122MP0004084_abnormal_cardiac_muscle0.82625937
123MP0000681_abnormal_thyroid_gland0.81903617
124MP0001177_atelectasis0.81205781
125MP0001963_abnormal_hearing_physiology0.79196477
126MP0000538_abnormal_urinary_bladder0.78813281
127MP0010307_abnormal_tumor_latency0.78361896
128MP0002160_abnormal_reproductive_system0.78121884
129MP0002102_abnormal_ear_morphology0.77009619
130MP0004742_abnormal_vestibular_system0.76400960
131MP0002069_abnormal_eating/drinking_beha0.76031501
132MP0002752_abnormal_somatic_nervous0.75832852
133MP0001919_abnormal_reproductive_system0.75335322
134MP0009697_abnormal_copulation0.74306203
135MP0003634_abnormal_glial_cell0.74036690
136MP0004885_abnormal_endolymph0.73803973
137MP0005423_abnormal_somatic_nervous0.72142678
138MP0003075_altered_response_to0.67498953
139MP0005595_abnormal_vascular_smooth0.66529016
140MP0005253_abnormal_eye_physiology0.63804586
141MP0003632_abnormal_nervous_system0.63687603
142MP0002229_neurodegeneration0.62689187
143MP0001299_abnormal_eye_distance/0.62376067
144MP0000026_abnormal_inner_ear0.61506841
145MP0008874_decreased_physiological_sensi0.59872405
146MP0002095_abnormal_skin_pigmentation0.59649603
147MP0003279_aneurysm0.58715328
148MP0001485_abnormal_pinna_reflex0.53996187
149MP0010770_preweaning_lethality0.52334619
150MP0002082_postnatal_lethality0.52334619

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97598875
2Visual hallucinations (HP:0002367)5.02398804
3Absence seizures (HP:0002121)5.01978561
4Focal seizures (HP:0007359)4.99229890
5Epileptic encephalopathy (HP:0200134)4.85231853
6Atonic seizures (HP:0010819)4.77973931
7Dialeptic seizures (HP:0011146)4.55515631
8Febrile seizures (HP:0002373)4.52176012
9Birth length less than 3rd percentile (HP:0003561)4.40453411
10Type II lissencephaly (HP:0007260)3.75597706
11Abnormal hair whorl (HP:0010721)3.68893093
12Gait imbalance (HP:0002141)3.67641059
13Pancreatic cysts (HP:0001737)3.62765525
14Volvulus (HP:0002580)3.58305015
15Congenital primary aphakia (HP:0007707)3.53396084
16Hyperventilation (HP:0002883)3.33528345
17Nephrogenic diabetes insipidus (HP:0009806)3.31202643
18Polyphagia (HP:0002591)3.26561127
19Cerebellar dysplasia (HP:0007033)3.25459453
20Protruding tongue (HP:0010808)3.17116856
21Generalized tonic-clonic seizures (HP:0002069)3.15924976
22Aplasia/Hypoplasia of the sternum (HP:0006714)3.09128578
23Failure to thrive in infancy (HP:0001531)3.09122625
24Medial flaring of the eyebrow (HP:0010747)3.05541935
25Thyroid-stimulating hormone excess (HP:0002925)3.04112102
26Poor suck (HP:0002033)3.03059908
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02022904
28Myokymia (HP:0002411)3.01249790
29True hermaphroditism (HP:0010459)2.93161688
30Nephronophthisis (HP:0000090)2.91431631
31Abnormality of the renal cortex (HP:0011035)2.90062507
32Intestinal atresia (HP:0011100)2.85924086
33Systemic lupus erythematosus (HP:0002725)2.80620605
34Molar tooth sign on MRI (HP:0002419)2.76895689
35Abnormality of midbrain morphology (HP:0002418)2.76895689
36Dysostosis multiplex (HP:0000943)2.76763257
37Poor coordination (HP:0002370)2.75572295
38Microvesicular hepatic steatosis (HP:0001414)2.74917829
39Large for gestational age (HP:0001520)2.73486920
40Abnormal eating behavior (HP:0100738)2.72890876
41Absent speech (HP:0001344)2.71496750
42Abnormality of the renal medulla (HP:0100957)2.70217809
43* Lissencephaly (HP:0001339)2.67260571
44Fair hair (HP:0002286)2.66548854
45Patellar aplasia (HP:0006443)2.65892338
46Menstrual irregularities (HP:0000858)2.64212411
47Congenital stationary night blindness (HP:0007642)2.60462740
48Chromsome breakage (HP:0040012)2.57173831
49Inability to walk (HP:0002540)2.56060046
50Poor eye contact (HP:0000817)2.55004504
51Chronic hepatic failure (HP:0100626)2.54414790
52Turricephaly (HP:0000262)2.52267806
53Abnormality of the ileum (HP:0001549)2.51962200
54Pendular nystagmus (HP:0012043)2.49003822
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.48208968
56Depressed nasal tip (HP:0000437)2.47843294
57Chorioretinal atrophy (HP:0000533)2.45413851
58Renal cortical cysts (HP:0000803)2.44835358
59Specific learning disability (HP:0001328)2.41440127
60Abnormality of the labia minora (HP:0012880)2.40528421
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.40322891
62Aplasia/Hypoplasia of the patella (HP:0006498)2.40108840
63Progressive cerebellar ataxia (HP:0002073)2.35803606
64Urinary bladder sphincter dysfunction (HP:0002839)2.35412747
65J-shaped sella turcica (HP:0002680)2.34760215
66Abnormality of the pons (HP:0007361)2.33673132
67Ectopic kidney (HP:0000086)2.32996226
68Impaired social interactions (HP:0000735)2.25850191
69Abnormal social behavior (HP:0012433)2.25850191
70Sleep apnea (HP:0010535)2.25832856
71Increased cerebral lipofuscin (HP:0011813)2.23657227
72Oligodactyly (hands) (HP:0001180)2.23393924
73Breast hypoplasia (HP:0003187)2.22823462
74Pachygyria (HP:0001302)2.22808981
75Mucopolysacchariduria (HP:0008155)2.22600430
76Urinary glycosaminoglycan excretion (HP:0003541)2.22600430
77Hypoplasia of the pons (HP:0012110)2.20677890
78Glioma (HP:0009733)2.19872614
79Vaginal atresia (HP:0000148)2.19512884
80Impaired vibration sensation in the lower limbs (HP:0002166)2.19399576
81Abnormality of alanine metabolism (HP:0010916)2.18973777
82Hyperalaninemia (HP:0003348)2.18973777
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18973777
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18733815
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18733815
86Abnormality of polysaccharide metabolism (HP:0011012)2.18733815
87Partial agenesis of the corpus callosum (HP:0001338)2.17876203
88Blue irides (HP:0000635)2.16809936
89Broad-based gait (HP:0002136)2.16368932
90Truncal ataxia (HP:0002078)2.16151047
91Epileptiform EEG discharges (HP:0011182)2.15410428
92Agitation (HP:0000713)2.15316175
93Abnormality of DNA repair (HP:0003254)2.12659767
94Tubular atrophy (HP:0000092)2.10406289
95Stereotypic behavior (HP:0000733)2.09463016
96Optic nerve hypoplasia (HP:0000609)2.08468368
97Loss of speech (HP:0002371)2.07865028
98Meckel diverticulum (HP:0002245)2.07510444
99Aplasia/Hypoplasia of the lens (HP:0008063)2.07030908
100Genital tract atresia (HP:0001827)2.06493393
101Attenuation of retinal blood vessels (HP:0007843)2.04575180
102Depression (HP:0000716)2.04335309
103Narrow nasal bridge (HP:0000446)2.04279342
104Heterochromia iridis (HP:0001100)2.03360126
105Abnormality of chromosome stability (HP:0003220)2.02379948
106Duplicated collecting system (HP:0000081)2.02051215
107Limb ataxia (HP:0002070)2.01184506
108Iris hypopigmentation (HP:0007730)1.98423305
109Abnormality of the astrocytes (HP:0100707)1.98340929
110Astrocytoma (HP:0009592)1.98340929
111Impaired smooth pursuit (HP:0007772)1.97164253
112Palpebral edema (HP:0100540)1.97114418
113Increased serum pyruvate (HP:0003542)1.96370194
114Abnormality of glycolysis (HP:0004366)1.96370194
115Sclerocornea (HP:0000647)1.94591205
116Excessive salivation (HP:0003781)1.93803542
117Drooling (HP:0002307)1.93803542
118Unsteady gait (HP:0002317)1.93395370
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92681754
120Urinary urgency (HP:0000012)1.90718912
121Gaze-evoked nystagmus (HP:0000640)1.90483606
122Hip dysplasia (HP:0001385)1.90436487
123Psychosis (HP:0000709)1.89725502
124EEG with generalized epileptiform discharges (HP:0011198)1.88160136
125Oligomenorrhea (HP:0000876)1.88020282
126Amblyopia (HP:0000646)1.86032855
127Hypoplastic labia majora (HP:0000059)1.85968944
128Scanning speech (HP:0002168)1.85901512
129Bilateral microphthalmos (HP:0007633)1.85781932
130Mutism (HP:0002300)1.84630692
131Abnormality of the carotid arteries (HP:0005344)1.83985421
132Broad foot (HP:0001769)1.83659224
133Abnormality of the renal collecting system (HP:0004742)1.83514489
134Colon cancer (HP:0003003)1.82973671
135Supranuclear gaze palsy (HP:0000605)1.82498566
136Sloping forehead (HP:0000340)1.82296790
137Abnormality of ocular smooth pursuit (HP:0000617)1.81649037
138Abnormal mitochondria in muscle tissue (HP:0008316)1.81551671
139Microtia (HP:0008551)1.81051847
140Generalized myoclonic seizures (HP:0002123)1.80927086
141Action tremor (HP:0002345)1.80545057
142Dysdiadochokinesis (HP:0002075)1.79822864
143Highly arched eyebrow (HP:0002553)1.79544730
144Clubbing of toes (HP:0100760)1.78528791
145Widely spaced teeth (HP:0000687)1.77997418
146Pheochromocytoma (HP:0002666)1.77076674
147Fetal akinesia sequence (HP:0001989)1.76892542
148Cystic liver disease (HP:0006706)1.76702947
149Anxiety (HP:0000739)1.76331223
150Anterior segment dysgenesis (HP:0007700)1.75736846
151Increased corneal curvature (HP:0100692)1.75477543
152Keratoconus (HP:0000563)1.75477543
153Long nose (HP:0003189)1.75340706
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.75254401
155Abnormality of the labia majora (HP:0012881)1.75039935
156Joint stiffness (HP:0001387)1.74013980
157Aqueductal stenosis (HP:0002410)1.73889964
158Generalized hypopigmentation of hair (HP:0011358)1.73715992
159Asymmetric septal hypertrophy (HP:0001670)1.72962229
160Neoplasm of the adrenal cortex (HP:0100641)1.72924229
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.72912140
162Progressive neurologic deterioration (HP:0002344)1.71423381
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70678792
164Polymicrogyria (HP:0002126)1.70238035
165* Dandy-Walker malformation (HP:0001305)1.70152336
166Spinal canal stenosis (HP:0003416)1.70089718
167Ankle clonus (HP:0011448)1.69329637
168Pancreatic fibrosis (HP:0100732)1.69050277
169Ependymoma (HP:0002888)1.68812929
170Scrotal hypoplasia (HP:0000046)1.68148546
171Progressive inability to walk (HP:0002505)1.68081810
172Abnormality of binocular vision (HP:0011514)1.66963194
173Diplopia (HP:0000651)1.66963194
174Congenital hepatic fibrosis (HP:0002612)1.66648594
175Neuroendocrine neoplasm (HP:0100634)1.66322111
176Preaxial hand polydactyly (HP:0001177)1.66016151
177Hypoplastic iliac wings (HP:0002866)1.65505497
178Genetic anticipation (HP:0003743)1.64672282
179Diastasis recti (HP:0001540)1.63827725
180Gastrointestinal atresia (HP:0002589)1.63210782
181Long foot (HP:0001833)1.63160953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.82427106
2ZAK4.23388931
3NTRK34.06363230
4MAP3K124.00974309
5ACVR1B3.67859386
6FRK3.64383296
7SIK33.50654095
8MAP2K73.26927575
9EPHA43.19946537
10MAP3K42.71799465
11MINK12.65102757
12DAPK22.48388596
13MAP2K42.47714426
14PLK22.41879937
15MAP3K92.39759213
16CCNB12.32857788
17DAPK12.21316443
18MARK12.14353141
19NTRK22.10373017
20CDK192.08497178
21MAP4K21.96111480
22CAMK1D1.89202591
23KSR11.89066128
24STK391.72669619
25TAOK31.71126467
26WNK41.68589944
27TSSK61.68439218
28MKNK21.65051158
29AKT31.55627412
30TGFBR11.51810732
31NUAK11.46602398
32PINK11.44360380
33PRPF4B1.38415007
34MAPK131.37174385
35PNCK1.34670741
36NEK21.27877142
37CDK81.26739867
38BRD41.24953839
39PRKCG1.24827196
40NEK11.24337690
41CAMKK21.21376785
42STK38L1.18133579
43CAMKK11.17760049
44MKNK11.16652583
45MST1R1.13137062
46TNIK1.10808684
47FES1.09608484
48CDK51.09475832
49SIK21.06244893
50MAP3K111.06069693
51INSRR1.06056060
52PLK41.06039857
53EPHB21.03975804
54EIF2AK11.03341178
55BRAF1.02818615
56GRK11.00340301
57TLK10.97999692
58CSNK1G20.96971766
59EEF2K0.95434436
60CSNK1A1L0.95054991
61SGK20.94241874
62RPS6KA50.93853317
63GRK50.93810948
64CHEK20.91539775
65SCYL20.88314105
66EIF2AK30.88262542
67BMPR1B0.87005572
68WEE10.86835973
69BLK0.86161762
70ERBB30.85723624
71CSNK1G30.84790134
72SGK2230.84144962
73SGK4940.84144962
74CSNK1G10.83628817
75STK160.82943609
76LMTK20.81294454
77BMPR20.81178114
78OXSR10.80892559
79FER0.79508823
80MAPKAPK50.78015605
81CDK180.77550888
82PAK30.77164304
83EIF2AK20.74595973
84FLT30.74542784
85ATR0.72862136
86CAMK2A0.71036123
87CDC70.70560043
88PRKCE0.70069280
89BCR0.66860140
90TRIM280.66311921
91ADRBK20.65310759
92NEK90.65223739
93GRK70.63841522
94PLK30.63536816
95CAMK10.61967309
96DAPK30.60723347
97MAP2K60.60605874
98CDK150.60244143
99CDK140.60237569
100MELK0.59541994
101ATM0.58892051
102LIMK10.57661456
103WNK30.57519125
104STK30.57102309
105BRSK10.56738529
106PLK10.54216814
107ADRBK10.53292248
108PTK2B0.53080060
109PRKAA10.52278124
110TRPM70.50795817
111UHMK10.50325644
112MAPK120.50033308
113RIPK40.49686371
114CDK11A0.48632651
115ARAF0.48350734
116TTK0.48237877
117KSR20.48217317
118CSNK1D0.47971659
119WNK10.46235580
120SGK30.45835400
121CAMK2B0.45385602
122MAPKAPK30.42613643
123PHKG20.42482941
124PHKG10.42482941
125PRKCH0.42273911
126AURKB0.41384984
127SRPK10.41144442
128VRK10.40845414
129ERBB20.40493138
130SYK0.39973794
131CAMK1G0.39413622
132BRSK20.38384863
133CAMK40.36637119
134FYN0.36424311
135BUB10.35927674
136MAPK70.35913340
137FGFR10.35876566
138DYRK1A0.35613228
139PBK0.35395893
140PRKCZ0.35264710
141STK240.34306261
142BCKDK0.32579598
143MAPK100.32017064
144STK380.31484465
145CHEK10.30649072
146FGFR20.30301941
147MAP2K10.30229476
148SGK10.29862578
149TAF10.29666897
150MUSK0.28961983
151PRKACB0.28864991
152DYRK20.28663997
153MAP3K10.28237212
154IRAK10.27824484
155CDK30.27416431
156RPS6KB10.26211223
157MAPK90.25924240
158TAOK20.25776966
159PRKCD0.22753366
160TXK0.22587317

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.58172616
2Nicotine addiction_Homo sapiens_hsa050334.06601530
3Collecting duct acid secretion_Homo sapiens_hsa049663.27424504
4Systemic lupus erythematosus_Homo sapiens_hsa053222.89747152
5Fanconi anemia pathway_Homo sapiens_hsa034602.88868665
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63752454
7Non-homologous end-joining_Homo sapiens_hsa034502.61527963
8Selenocompound metabolism_Homo sapiens_hsa004502.61310697
9Morphine addiction_Homo sapiens_hsa050322.48100803
10Vibrio cholerae infection_Homo sapiens_hsa051102.44710705
11Olfactory transduction_Homo sapiens_hsa047402.41574412
12Circadian entrainment_Homo sapiens_hsa047132.38740953
13GABAergic synapse_Homo sapiens_hsa047272.29735008
14Basal transcription factors_Homo sapiens_hsa030222.29359640
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11365649
16Long-term potentiation_Homo sapiens_hsa047202.10329641
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.02102264
18RNA degradation_Homo sapiens_hsa030182.01510627
19Dopaminergic synapse_Homo sapiens_hsa047282.01139296
20Amphetamine addiction_Homo sapiens_hsa050311.91926249
21Glutamatergic synapse_Homo sapiens_hsa047241.86266196
22Insulin secretion_Homo sapiens_hsa049111.80760797
23Serotonergic synapse_Homo sapiens_hsa047261.78679679
24Other glycan degradation_Homo sapiens_hsa005111.77291361
25RNA transport_Homo sapiens_hsa030131.74318180
26RNA polymerase_Homo sapiens_hsa030201.73506359
27Nitrogen metabolism_Homo sapiens_hsa009101.64545227
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60597330
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59232410
30Nucleotide excision repair_Homo sapiens_hsa034201.57452319
31Cholinergic synapse_Homo sapiens_hsa047251.54328001
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50760364
33Cell cycle_Homo sapiens_hsa041101.49530667
34Phagosome_Homo sapiens_hsa041451.49283572
35Butanoate metabolism_Homo sapiens_hsa006501.48560802
36Salivary secretion_Homo sapiens_hsa049701.45779739
37Taste transduction_Homo sapiens_hsa047421.43683957
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42638295
39Rheumatoid arthritis_Homo sapiens_hsa053231.41249113
40Dorso-ventral axis formation_Homo sapiens_hsa043201.41106919
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40613390
42Lysine degradation_Homo sapiens_hsa003101.40082362
43ABC transporters_Homo sapiens_hsa020101.38536501
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36814592
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36585553
46Calcium signaling pathway_Homo sapiens_hsa040201.36173530
47Lysosome_Homo sapiens_hsa041421.35651181
48N-Glycan biosynthesis_Homo sapiens_hsa005101.35465058
49Linoleic acid metabolism_Homo sapiens_hsa005911.33756538
50Long-term depression_Homo sapiens_hsa047301.32915185
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.30863287
52Cocaine addiction_Homo sapiens_hsa050301.30544819
53Steroid biosynthesis_Homo sapiens_hsa001001.28061562
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26747590
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26638028
56Fatty acid biosynthesis_Homo sapiens_hsa000611.22151795
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20510437
58Propanoate metabolism_Homo sapiens_hsa006401.19326239
59Renin secretion_Homo sapiens_hsa049241.17772922
60Axon guidance_Homo sapiens_hsa043601.17660716
61One carbon pool by folate_Homo sapiens_hsa006701.17203970
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16880841
63Ether lipid metabolism_Homo sapiens_hsa005651.16289566
64Oxytocin signaling pathway_Homo sapiens_hsa049211.15142593
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11875129
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.11701372
67Gap junction_Homo sapiens_hsa045401.09699164
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08317187
69p53 signaling pathway_Homo sapiens_hsa041151.07394341
70DNA replication_Homo sapiens_hsa030301.07252955
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04613940
72mRNA surveillance pathway_Homo sapiens_hsa030151.03929252
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01242516
74Hippo signaling pathway_Homo sapiens_hsa043900.97360977
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96731423
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95039228
77Tryptophan metabolism_Homo sapiens_hsa003800.94127653
78Melanogenesis_Homo sapiens_hsa049160.94103097
79GnRH signaling pathway_Homo sapiens_hsa049120.91605823
80Ovarian steroidogenesis_Homo sapiens_hsa049130.91319115
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90940325
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90891465
83Sulfur metabolism_Homo sapiens_hsa009200.88989550
84Gastric acid secretion_Homo sapiens_hsa049710.88718346
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86012755
86Purine metabolism_Homo sapiens_hsa002300.85112455
87Glioma_Homo sapiens_hsa052140.84345308
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80777593
89Pertussis_Homo sapiens_hsa051330.80370418
90Base excision repair_Homo sapiens_hsa034100.79451682
91Type I diabetes mellitus_Homo sapiens_hsa049400.76879357
92Oxidative phosphorylation_Homo sapiens_hsa001900.76612520
93TGF-beta signaling pathway_Homo sapiens_hsa043500.75935724
94Pyrimidine metabolism_Homo sapiens_hsa002400.75149608
95Basal cell carcinoma_Homo sapiens_hsa052170.73777111
96Colorectal cancer_Homo sapiens_hsa052100.72084093
97cAMP signaling pathway_Homo sapiens_hsa040240.70955998
98Protein export_Homo sapiens_hsa030600.70759889
99ErbB signaling pathway_Homo sapiens_hsa040120.70547684
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.69885362
101Phototransduction_Homo sapiens_hsa047440.67261756
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67018115
103Prion diseases_Homo sapiens_hsa050200.66529424
104Hedgehog signaling pathway_Homo sapiens_hsa043400.65101739
105MAPK signaling pathway_Homo sapiens_hsa040100.62481549
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61518508
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60042198
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.59069579
109Estrogen signaling pathway_Homo sapiens_hsa049150.59049610
110Peroxisome_Homo sapiens_hsa041460.58583461
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57064683
112Viral carcinogenesis_Homo sapiens_hsa052030.54909319
113Staphylococcus aureus infection_Homo sapiens_hsa051500.53445930
114Homologous recombination_Homo sapiens_hsa034400.53442854
115Oocyte meiosis_Homo sapiens_hsa041140.53261950
116Alzheimers disease_Homo sapiens_hsa050100.52566741
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52434370
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51673887
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51348807
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.50885348
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48393920
122Glycerolipid metabolism_Homo sapiens_hsa005610.47728215
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46632358
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46567790
125Alcoholism_Homo sapiens_hsa050340.45883646
126Tuberculosis_Homo sapiens_hsa051520.45770199
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44887661
128Rap1 signaling pathway_Homo sapiens_hsa040150.42090565
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.41182154
130MicroRNAs in cancer_Homo sapiens_hsa052060.40903956
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39086080
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37005838
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34920635
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34726784
135Inositol phosphate metabolism_Homo sapiens_hsa005620.34714556
136Type II diabetes mellitus_Homo sapiens_hsa049300.34528048
137Dilated cardiomyopathy_Homo sapiens_hsa054140.34470498
138Endocytosis_Homo sapiens_hsa041440.34132351
139Caffeine metabolism_Homo sapiens_hsa002320.34068936
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32592370
141Parkinsons disease_Homo sapiens_hsa050120.32416155
142Ras signaling pathway_Homo sapiens_hsa040140.32329787
143Sphingolipid metabolism_Homo sapiens_hsa006000.31462610
144Metabolic pathways_Homo sapiens_hsa011000.31052019
145Melanoma_Homo sapiens_hsa052180.30912804
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.30071529
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29668891
148Pancreatic secretion_Homo sapiens_hsa049720.27804532
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25918262
150VEGF signaling pathway_Homo sapiens_hsa043700.25698873
151Wnt signaling pathway_Homo sapiens_hsa043100.24569850
152Circadian rhythm_Homo sapiens_hsa047100.24402637
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.24374373
154Huntingtons disease_Homo sapiens_hsa050160.23527110
155Thyroid hormone synthesis_Homo sapiens_hsa049180.22542893
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22461402
157Mismatch repair_Homo sapiens_hsa034300.21437720
158Cardiac muscle contraction_Homo sapiens_hsa042600.20127286
159Endometrial cancer_Homo sapiens_hsa052130.19732373
160Phospholipase D signaling pathway_Homo sapiens_hsa040720.19165233
161Spliceosome_Homo sapiens_hsa030400.18823242

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