POM121L6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.54601409
2response to pheromone (GO:0019236)9.41385027
3sperm motility (GO:0030317)9.25395310
4fusion of sperm to egg plasma membrane (GO:0007342)8.29049668
5chromosome condensation (GO:0030261)7.41692394
6sperm capacitation (GO:0048240)7.28614110
7DNA packaging (GO:0006323)7.26538651
8protein targeting to Golgi (GO:0000042)6.96187280
9establishment of protein localization to Golgi (GO:0072600)6.86967357
10spermatid development (GO:0007286)6.75471432
11retrograde transport, vesicle recycling within Golgi (GO:0000301)6.51991019
12rRNA methylation (GO:0031167)6.34916183
13single strand break repair (GO:0000012)6.34715685
14plasma membrane fusion (GO:0045026)6.16654053
15microtubule depolymerization (GO:0007019)6.10368371
16cellular ketone body metabolic process (GO:0046950)5.85389574
17sperm-egg recognition (GO:0035036)5.61277520
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57197551
19regulation of G0 to G1 transition (GO:0070316)5.39141436
20spermatid nucleus differentiation (GO:0007289)5.38391372
21protein localization to Golgi apparatus (GO:0034067)5.35423764
22negative regulation of inclusion body assembly (GO:0090084)5.31780493
23multicellular organism reproduction (GO:0032504)5.25978210
24calcium ion-dependent exocytosis (GO:0017156)5.16337797
25ketone body metabolic process (GO:1902224)5.12634980
26rRNA modification (GO:0000154)5.10868596
27regulation of ARF GTPase activity (GO:0032312)5.10353341
28binding of sperm to zona pellucida (GO:0007339)5.04528242
29reproduction (GO:0000003)5.02118989
30spermatogenesis (GO:0007283)4.94955320
31microtubule polymerization or depolymerization (GO:0031109)4.94885297
32sexual reproduction (GO:0019953)4.94601010
33male gamete generation (GO:0048232)4.93351875
34phosphatidylethanolamine biosynthetic process (GO:0006646)4.92961133
35positive regulation of Rab GTPase activity (GO:0032851)4.83568128
36regulation of Rab GTPase activity (GO:0032313)4.83568128
37cell-cell recognition (GO:0009988)4.79282691
38protein polyglutamylation (GO:0018095)4.69067312
39RNA destabilization (GO:0050779)4.62951335
40chromatin silencing (GO:0006342)4.55704282
41phosphatidylethanolamine metabolic process (GO:0046337)4.52735029
42maintenance of gastrointestinal epithelium (GO:0030277)4.51255174
43cell wall macromolecule catabolic process (GO:0016998)4.47859653
44gamete generation (GO:0007276)4.45848851
45regulation of cilium movement (GO:0003352)4.31244268
46response to vitamin A (GO:0033189)4.21663834
47coenzyme catabolic process (GO:0009109)4.19294381
48cell wall macromolecule metabolic process (GO:0044036)4.07137369
49axonemal dynein complex assembly (GO:0070286)3.98802772
50mesenchymal cell differentiation involved in kidney development (GO:0072161)3.90890910
51mesenchymal cell differentiation involved in renal system development (GO:2001012)3.90890910
52regulation of inclusion body assembly (GO:0090083)3.87091720
53negative regulation of Rho protein signal transduction (GO:0035024)3.87029468
54motile cilium assembly (GO:0044458)3.85391215
55germ cell development (GO:0007281)3.79827609
56microtubule severing (GO:0051013)3.75482386
57cilium or flagellum-dependent cell motility (GO:0001539)3.67843712
58single fertilization (GO:0007338)3.66477989
59regulation of transcription involved in cell fate commitment (GO:0060850)3.64332423
60multicellular organismal reproductive process (GO:0048609)3.57792729
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.52307660
62actin filament capping (GO:0051693)3.30132714
63O-glycan processing (GO:0016266)3.28205071
64Golgi to endosome transport (GO:0006895)3.28119973
65histone H3-K9 demethylation (GO:0033169)3.27956384
66NAD biosynthetic process (GO:0009435)3.27735725
67epithelial structure maintenance (GO:0010669)3.27442533
68regulation of mesoderm development (GO:2000380)3.23668300
69nephron epithelium morphogenesis (GO:0072088)3.21309648
70nephron tubule morphogenesis (GO:0072078)3.21309648
71histone H3 deacetylation (GO:0070932)3.15127304
72negative regulation of gene expression, epigenetic (GO:0045814)3.10372468
73lactate metabolic process (GO:0006089)3.09686436
74nucleus organization (GO:0006997)3.09095391
75somite rostral/caudal axis specification (GO:0032525)3.08379768
76estrogen biosynthetic process (GO:0006703)3.04973218
77intra-Golgi vesicle-mediated transport (GO:0006891)3.04877853
78glycerol ether metabolic process (GO:0006662)2.99547580
79cell differentiation involved in metanephros development (GO:0072202)2.98149189
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91188677
81epithelial cell fate commitment (GO:0072148)2.88817751
82protein-DNA complex disassembly (GO:0032986)2.87925825
83nucleosome disassembly (GO:0006337)2.87925825
84regulation of somitogenesis (GO:0014807)2.84757778
85peptidyl-threonine dephosphorylation (GO:0035970)2.82283240
86centriole replication (GO:0007099)2.81583658
87coronary vasculature morphogenesis (GO:0060977)2.81488724
88fertilization (GO:0009566)2.80874874
89receptor recycling (GO:0001881)2.74912311
90DNA conformation change (GO:0071103)2.74585905
91ether metabolic process (GO:0018904)2.74474252
92negative regulation of actin filament depolymerization (GO:0030835)2.74347767
93genitalia morphogenesis (GO:0035112)2.73377716
94protein depolymerization (GO:0051261)2.72951395
95regulation of microtubule-based movement (GO:0060632)2.72858622
96peptidyl-proline hydroxylation (GO:0019511)2.72826853
97inner cell mass cell proliferation (GO:0001833)2.72193515
98regulation of phosphoprotein phosphatase activity (GO:0043666)2.65557264
99cell migration involved in gastrulation (GO:0042074)2.65293355
100regulation of acrosome reaction (GO:0060046)2.62860651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42946717
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.28903997
3DROSHA_22980978_ChIP-Seq_HELA_Human3.16636959
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.63471439
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41958544
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.24260658
7WDR5_24793694_ChIP-Seq_LNCAP_Human2.15370542
8CBP_20019798_ChIP-Seq_JUKART_Human2.09615669
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09615669
10ERA_21632823_ChIP-Seq_H3396_Human2.09273583
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07808751
12CTCF_27219007_Chip-Seq_Bcells_Human2.05574258
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98695526
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95026597
15EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.92412242
16SMC4_20622854_ChIP-Seq_HELA_Human1.84657348
17BCL6_27268052_Chip-Seq_Bcells_Human1.84363627
18E2F1_20622854_ChIP-Seq_HELA_Human1.84222077
19P68_20966046_ChIP-Seq_HELA_Human1.76625071
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75208319
21PHF8_20622854_ChIP-Seq_HELA_Human1.70408880
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70338653
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70338653
24BCOR_27268052_Chip-Seq_Bcells_Human1.69895780
25ER_23166858_ChIP-Seq_MCF-7_Human1.66866680
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65517206
27ZNF274_21170338_ChIP-Seq_K562_Hela1.64716688
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62876657
29RAC3_21632823_ChIP-Seq_H3396_Human1.62733860
30SMAD4_21741376_ChIP-Seq_HESCs_Human1.62393220
31NANOG_20526341_ChIP-Seq_ESCs_Human1.61996282
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61775824
33OCT4_20526341_ChIP-Seq_ESCs_Human1.59811111
34TP63_22573176_ChIP-Seq_HFKS_Human1.57195626
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.55308477
36TAF2_19829295_ChIP-Seq_ESCs_Human1.55097913
37MYC_19829295_ChIP-Seq_ESCs_Human1.52746816
38CTCF_20526341_ChIP-Seq_ESCs_Human1.52388666
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49847469
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48536302
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.48388367
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46108500
43FUS_26573619_Chip-Seq_HEK293_Human1.43838873
44P300_27268052_Chip-Seq_Bcells_Human1.43554386
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40009638
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.35104933
47LXR_22292898_ChIP-Seq_THP-1_Human1.34280485
48AR_25329375_ChIP-Seq_VCAP_Human1.32801696
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31918706
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.31309605
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.30962339
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28954065
53P53_21459846_ChIP-Seq_SAOS-2_Human1.28399915
54SA1_27219007_Chip-Seq_Bcells_Human1.27570223
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27003046
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.26808563
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26776105
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25728273
59HOXB7_26014856_ChIP-Seq_BT474_Human1.25569561
60HNFA_21074721_ChIP-Seq_CACO-2_Human1.22760866
61TP53_18474530_ChIP-ChIP_U2OS_Human1.22353215
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.21479640
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.18935924
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.16808858
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16227763
66E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15682303
67NFYA_21822215_ChIP-Seq_K562_Human1.15180108
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15109873
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13204694
70NFYB_21822215_ChIP-Seq_K562_Human1.12658802
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12571035
72RUNX_20019798_ChIP-Seq_JUKART_Human1.11785054
73RBPJ_21746931_ChIP-Seq_IB4_Human1.11766953
74CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11497275
75OCT4_19829295_ChIP-Seq_ESCs_Human1.11139685
76SMRT_27268052_Chip-Seq_Bcells_Human1.08838854
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08814758
78FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08713202
79TBL1_22424771_ChIP-Seq_293T_Human1.08158102
80TAF15_26573619_Chip-Seq_HEK293_Human1.07129042
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06100211
82RUNX2_22187159_ChIP-Seq_PCA_Human1.05084538
83ETV1_20927104_ChIP-Seq_GIST48_Human1.04750777
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.04452940
85GBX2_23144817_ChIP-Seq_PC3_Human1.03810930
86KLF5_25053715_ChIP-Seq_YYC3_Human1.01547779
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99145563
88PHF8_20622853_ChIP-Seq_HELA_Human0.98630838
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96502235
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96413161
91REST_21632747_ChIP-Seq_MESCs_Mouse0.96277525
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95359356
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93787303
94SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93240252
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92246223
96P300_19829295_ChIP-Seq_ESCs_Human0.91879924
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.91587704
98STAT3_23295773_ChIP-Seq_U87_Human0.91437862
99CEBPB_22108803_ChIP-Seq_LS180_Human0.90267908
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.89947534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.48435920
2MP0008995_early_reproductive_senescence4.44533281
3MP0003878_abnormal_ear_physiology4.22674219
4MP0005377_hearing/vestibular/ear_phenot4.22674219
5MP0003698_abnormal_male_reproductive3.49803625
6MP0001348_abnormal_lacrimal_gland3.24279886
7MP0001929_abnormal_gametogenesis2.86973722
8MP0005670_abnormal_white_adipose2.72362801
9MP0003890_abnormal_embryonic-extraembry2.24000806
10MP0008961_abnormal_basal_metabolism2.22059702
11MP0001765_abnormal_ion_homeostasis2.17471519
12MP0002822_catalepsy2.13238670
13MP0002254_reproductive_system_inflammat2.06706067
14MP0001485_abnormal_pinna_reflex1.98155382
15MP0002234_abnormal_pharynx_morphology1.94841286
16MP0005187_abnormal_penis_morphology1.93095301
17MP0009053_abnormal_anal_canal1.92964382
18MP0001501_abnormal_sleep_pattern1.92074834
19MP0002161_abnormal_fertility/fecundity1.91382339
20MP0000566_synostosis1.79737991
21MP0000465_gastrointestinal_hemorrhage1.77931505
22MP0003879_abnormal_hair_cell1.77903838
23MP0005379_endocrine/exocrine_gland_phen1.75432172
24MP0001666_abnormal_nutrient_absorption1.67481861
25MP0003646_muscle_fatigue1.60508882
26MP0005083_abnormal_biliary_tract1.56398642
27MP0005310_abnormal_salivary_gland1.53916031
28MP0002127_abnormal_cardiovascular_syste1.45889797
29MP0001963_abnormal_hearing_physiology1.38081800
30MP0004742_abnormal_vestibular_system1.35676912
31MP0000579_abnormal_nail_morphology1.30311891
32MP0000467_abnormal_esophagus_morphology1.28793448
33MP0003786_premature_aging1.28006443
34MP0002138_abnormal_hepatobiliary_system1.27614550
35MP0003718_maternal_effect1.27150401
36MP0003011_delayed_dark_adaptation1.24026307
37MP0000026_abnormal_inner_ear1.22389054
38MP0005551_abnormal_eye_electrophysiolog1.21896459
39MP0002210_abnormal_sex_determination1.16458330
40MP0000678_abnormal_parathyroid_gland1.16245950
41MP0002249_abnormal_larynx_morphology1.15792437
42MP0003172_abnormal_lysosome_physiology1.15058997
43MP0001968_abnormal_touch/_nociception1.13766654
44MP0001486_abnormal_startle_reflex1.09795319
45MP0005423_abnormal_somatic_nervous1.08911639
46MP0005636_abnormal_mineral_homeostasis1.08231313
47MP0001873_stomach_inflammation1.06840534
48MP0002132_abnormal_respiratory_system1.05634206
49MP0004043_abnormal_pH_regulation1.05259884
50MP0003880_abnormal_central_pattern0.99587165
51MP0000653_abnormal_sex_gland0.99217346
52MP0002735_abnormal_chemical_nociception0.98450551
53MP0008004_abnormal_stomach_pH0.97178652
54MP0002229_neurodegeneration0.97119489
55MP0000470_abnormal_stomach_morphology0.96075534
56MP0004270_analgesia0.95836589
57MP0001661_extended_life_span0.95140176
58MP0001145_abnormal_male_reproductive0.94738702
59MP0000003_abnormal_adipose_tissue0.93742314
60MP0005257_abnormal_intraocular_pressure0.92087777
61MP0000647_abnormal_sebaceous_gland0.92082425
62MP0005253_abnormal_eye_physiology0.89264528
63MP0004233_abnormal_muscle_weight0.89070335
64MP0000613_abnormal_salivary_gland0.86815922
65MP0001502_abnormal_circadian_rhythm0.83941970
66MP0000230_abnormal_systemic_arterial0.83903047
67MP0000955_abnormal_spinal_cord0.83034910
68MP0003091_abnormal_cell_migration0.81309727
69MP0004510_myositis0.81283707
70MP0002067_abnormal_sensory_capabilities0.79251869
71MP0002557_abnormal_social/conspecific_i0.78811106
72MP0000049_abnormal_middle_ear0.78029421
73MP0002060_abnormal_skin_morphology0.76892925
74MP0004264_abnormal_extraembryonic_tissu0.75811604
75MP0001664_abnormal_digestion0.73278198
76MP0004019_abnormal_vitamin_homeostasis0.70284418
77MP0002733_abnormal_thermal_nociception0.68951104
78MP0003137_abnormal_impulse_conducting0.68809959
79MP0004085_abnormal_heartbeat0.68507131
80MP0001986_abnormal_taste_sensitivity0.64809301
81MP0005365_abnormal_bile_salt0.63407731
82MP0009384_cardiac_valve_regurgitation0.61850197
83MP0009780_abnormal_chondrocyte_physiolo0.60937191
84MP0003119_abnormal_digestive_system0.60870854
85MP0002693_abnormal_pancreas_physiology0.57293649
86MP0003283_abnormal_digestive_organ0.56445503
87MP0000015_abnormal_ear_pigmentation0.54820206
88MP0004133_heterotaxia0.54722962
89MP0002638_abnormal_pupillary_reflex0.54337152
90MP0002184_abnormal_innervation0.54189358
91MP0002837_dystrophic_cardiac_calcinosis0.53900482
92MP0009046_muscle_twitch0.52608282
93MP0005395_other_phenotype0.52483176
94MP0000569_abnormal_digit_pigmentation0.51698936
95MP0000538_abnormal_urinary_bladder0.50822038
96MP0002098_abnormal_vibrissa_morphology0.48768201
97MP0000516_abnormal_urinary_system0.48635572
98MP0005367_renal/urinary_system_phenotyp0.48635572
99MP0002572_abnormal_emotion/affect_behav0.47385971
100MP0004484_altered_response_of0.47100787

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)5.83243439
2Double outlet right ventricle (HP:0001719)5.83243439
3Severe visual impairment (HP:0001141)5.79025311
4Intestinal atresia (HP:0011100)5.60069993
5Abnormality of the parathyroid morphology (HP:0011766)5.16428464
6Anal stenosis (HP:0002025)4.80592569
7Nuclear cataract (HP:0100018)4.79898083
8Attenuation of retinal blood vessels (HP:0007843)4.56903267
9Bony spicule pigmentary retinopathy (HP:0007737)4.50473347
10Oligodactyly (hands) (HP:0001180)4.48266117
11Esophageal atresia (HP:0002032)4.02278146
12Enlarged epiphyses (HP:0010580)3.84878556
13Hyperkalemia (HP:0002153)3.64871764
14Aqueductal stenosis (HP:0002410)3.44292019
15Abnormal rod and cone electroretinograms (HP:0008323)3.43996360
16Chin dimple (HP:0010751)3.43812773
17Down-sloping shoulders (HP:0200021)3.43034386
18Labial hypoplasia (HP:0000066)3.38256353
19Mixed hearing impairment (HP:0000410)3.35786468
20Popliteal pterygium (HP:0009756)3.18732061
21Gastrointestinal atresia (HP:0002589)3.14641574
22Hypoplastic female external genitalia (HP:0012815)3.10876297
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05965884
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.01227560
25Abnormality of the distal phalanges of the toes (HP:0010182)3.00862656
26Oligodactyly (HP:0012165)2.91538110
27Progressive cerebellar ataxia (HP:0002073)2.88846517
28Hypoplastic ischia (HP:0003175)2.74816829
29Deep palmar crease (HP:0006191)2.72095468
30Facial shape deformation (HP:0011334)2.71011638
31Potter facies (HP:0002009)2.71011638
32Impulsivity (HP:0100710)2.69831755
33Abnormality of the labia (HP:0000058)2.59210143
34Asymmetric septal hypertrophy (HP:0001670)2.56804359
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56084246
36Aplasia involving forearm bones (HP:0009822)2.43771435
37Absent forearm bone (HP:0003953)2.43771435
38Abnormality of the ischium (HP:0003174)2.40295644
39Absent radius (HP:0003974)2.40235708
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38038501
41Chromsome breakage (HP:0040012)2.37724875
42Stridor (HP:0010307)2.37309794
43Unilateral renal agenesis (HP:0000122)2.36512313
44Abnormality of the aortic arch (HP:0012303)2.36428208
45Malnutrition (HP:0004395)2.35228998
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33515460
47Bell-shaped thorax (HP:0001591)2.31889707
48Pendular nystagmus (HP:0012043)2.30925603
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.28828464
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.22784348
51Absent/shortened dynein arms (HP:0200106)2.22784348
52Male infertility (HP:0003251)2.22409964
53Generalized aminoaciduria (HP:0002909)2.21983738
54Cupped ear (HP:0000378)2.21070872
55Infertility (HP:0000789)2.20352931
56Tubulointerstitial nephritis (HP:0001970)2.19168964
57Abnormality of the labia majora (HP:0012881)2.15656900
58Duplicated collecting system (HP:0000081)2.15071210
59Hypoplastic labia majora (HP:0000059)2.13685227
60Abnormality of potassium homeostasis (HP:0011042)2.09961231
61Abnormality of chloride homeostasis (HP:0011422)2.08053157
62Abnormality of macular pigmentation (HP:0008002)2.07905381
63Palpebral edema (HP:0100540)2.06974881
64Hypophosphatemic rickets (HP:0004912)2.06272047
65Short thumb (HP:0009778)2.05769856
66Hypoplasia of the thymus (HP:0000778)2.04843211
67Progressive sensorineural hearing impairment (HP:0000408)2.04798902
68Broad face (HP:0000283)2.03555598
69Abnormality of the costochondral junction (HP:0000919)2.01185868
70Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.98295479
71Widely patent fontanelles and sutures (HP:0004492)1.97626602
72Resting tremor (HP:0002322)1.96893332
73Abnormality of the femoral head (HP:0003368)1.96452307
74Abnormality of the duodenum (HP:0002246)1.96418427
75Chronic hepatic failure (HP:0100626)1.94290632
76Distal upper limb amyotrophy (HP:0007149)1.94028288
77Upper limb amyotrophy (HP:0009129)1.94028288
78Laryngomalacia (HP:0001601)1.91789885
79Zonular cataract (HP:0010920)1.91224403
80Congenital sensorineural hearing impairment (HP:0008527)1.90752657
81Abdominal situs inversus (HP:0003363)1.89978989
82Abnormality of abdominal situs (HP:0011620)1.89978989
83Horseshoe kidney (HP:0000085)1.89533034
84Pili torti (HP:0003777)1.85598033
85Hand muscle atrophy (HP:0009130)1.81922644
86Anencephaly (HP:0002323)1.80308517
87Abnormality of the nasal septum (HP:0000419)1.79690386
88Abnormality of the renal collecting system (HP:0004742)1.78544851
89Bilateral sensorineural hearing impairment (HP:0008619)1.77345501
90Delayed epiphyseal ossification (HP:0002663)1.76044321
91Absent thumb (HP:0009777)1.75551290
92Urethral obstruction (HP:0000796)1.74828448
93Obsessive-compulsive behavior (HP:0000722)1.74508498
94Renovascular hypertension (HP:0100817)1.72758163
95Decreased circulating renin level (HP:0003351)1.71462757
96Abnormality of the preputium (HP:0100587)1.71194694
97Neonatal respiratory distress (HP:0002643)1.68788972
98Flattened epiphyses (HP:0003071)1.68532298
99Abnormality of the epiphysis of the femoral head (HP:0010574)1.68377931
100Cleft eyelid (HP:0000625)1.66651517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.86543620
2WNK44.37438541
3INSRR4.04072557
4TESK13.77098887
5PLK43.76025850
6MAP3K33.59042975
7MAP3K23.41733566
8DDR23.32315820
9MAP4K22.94108999
10CDK122.82180537
11NME12.66185545
12WNK12.64381995
13BRD42.29390753
14FRK2.10476090
15STK381.92782413
16CAMK1G1.72610427
17MAP3K91.68370422
18MAPK151.58216290
19ERBB41.47554571
20PLK21.47480959
21PKN21.32609988
22MET1.29330064
23CAMK1D1.24189638
24SIK21.18006387
25ICK1.17249050
26MUSK1.04133434
27PDK10.98194914
28PDPK10.97938134
29MST40.97818936
30ZAK0.93732006
31TNK20.93672889
32TLK10.91852395
33MAP2K60.91383383
34PRKAA20.89119529
35MAP2K20.88989620
36MAP3K70.84445558
37RPS6KA20.82339155
38STK390.80134444
39PINK10.79774263
40PRKG20.79211333
41CDK70.76800110
42BMPR1B0.76563598
43GRK10.76148246
44ERBB20.74452691
45FGFR20.73742717
46NEK60.72924649
47EPHA30.70633072
48GRK60.67845437
49DYRK1B0.67746187
50MTOR0.64961657
51RPS6KA10.63620625
52PRKAA10.61028539
53PTK2B0.59480910
54FLT30.58087224
55PIK3CG0.56729700
56PNCK0.55915361
57BLK0.55256607
58CHUK0.55243529
59TRPM70.51893989
60RPS6KL10.51097438
61RPS6KC10.51097438
62BCKDK0.50526138
63RPS6KA60.49431852
64PASK0.47697750
65SGK10.46894992
66CHEK10.45674088
67MARK20.45372268
68SGK2230.43668671
69SGK4940.43668671
70ARAF0.43553739
71MAPK110.43325073
72MAPK10.42752301
73PRKD30.41527296
74GSK3B0.41336597
75PHKG10.40898732
76PHKG20.40898732
77TAOK30.40104230
78PRKG10.39744043
79MAP3K40.39183686
80ACVR1B0.39113341
81LMTK20.36476359
82ROCK10.36397908
83NEK20.35753488
84STK38L0.34387807
85MAPK130.33438814
86AKT30.32939880
87PTK60.32415374
88CAMK10.32191220
89MAP3K130.32166117
90SGK20.31790621
91CDK20.30831844
92AKT10.30696313
93CSNK1D0.30473920
94CDK10.30436528
95DAPK20.28435188
96MAPK80.28176882
97SGK30.27447580
98PIM20.26743476
99PIM10.25403142
100CDC42BPA0.24390203

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.18941108
2Fatty acid biosynthesis_Homo sapiens_hsa000613.40883347
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.17373837
4Olfactory transduction_Homo sapiens_hsa047402.63932743
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.42789521
6Butanoate metabolism_Homo sapiens_hsa006502.37605756
7Fanconi anemia pathway_Homo sapiens_hsa034602.15188318
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.88150558
9Salivary secretion_Homo sapiens_hsa049701.79312679
10Type II diabetes mellitus_Homo sapiens_hsa049301.79130366
11Phototransduction_Homo sapiens_hsa047441.79072294
12ABC transporters_Homo sapiens_hsa020101.74851288
13Fatty acid metabolism_Homo sapiens_hsa012121.74225706
14Selenocompound metabolism_Homo sapiens_hsa004501.66132064
15Circadian entrainment_Homo sapiens_hsa047131.65585103
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.65430509
17Taste transduction_Homo sapiens_hsa047421.57164027
18Circadian rhythm_Homo sapiens_hsa047101.50191024
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49674766
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48258836
21Oocyte meiosis_Homo sapiens_hsa041141.47208201
22Fructose and mannose metabolism_Homo sapiens_hsa000511.41600928
23Insulin secretion_Homo sapiens_hsa049111.35248110
24Lysine degradation_Homo sapiens_hsa003101.34765584
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33374364
26Protein digestion and absorption_Homo sapiens_hsa049741.31708228
27Arginine and proline metabolism_Homo sapiens_hsa003301.30819973
28Type I diabetes mellitus_Homo sapiens_hsa049401.24540543
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22201580
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.18376456
31Fatty acid degradation_Homo sapiens_hsa000711.16678017
32Peroxisome_Homo sapiens_hsa041461.16574534
33Dorso-ventral axis formation_Homo sapiens_hsa043201.15762400
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12710862
35Phenylalanine metabolism_Homo sapiens_hsa003601.09919810
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07520960
37Inositol phosphate metabolism_Homo sapiens_hsa005621.03112881
38Calcium signaling pathway_Homo sapiens_hsa040200.98633420
39Arginine biosynthesis_Homo sapiens_hsa002200.97761155
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97689729
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93516032
42Gastric acid secretion_Homo sapiens_hsa049710.93492208
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91968743
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89684374
45cAMP signaling pathway_Homo sapiens_hsa040240.89013822
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87265343
47Endocytosis_Homo sapiens_hsa041440.86655295
48Autoimmune thyroid disease_Homo sapiens_hsa053200.84561103
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83603563
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81862094
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80194642
52Retinol metabolism_Homo sapiens_hsa008300.77365222
53Allograft rejection_Homo sapiens_hsa053300.77336826
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76655761
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76058523
56Pancreatic secretion_Homo sapiens_hsa049720.74667515
57Antigen processing and presentation_Homo sapiens_hsa046120.74220360
58Basal transcription factors_Homo sapiens_hsa030220.71823798
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70813961
60Nitrogen metabolism_Homo sapiens_hsa009100.70274147
61Linoleic acid metabolism_Homo sapiens_hsa005910.69660130
62Graft-versus-host disease_Homo sapiens_hsa053320.69232262
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67892075
64Glucagon signaling pathway_Homo sapiens_hsa049220.67177341
65Tryptophan metabolism_Homo sapiens_hsa003800.64729473
66Morphine addiction_Homo sapiens_hsa050320.64683481
67Nicotine addiction_Homo sapiens_hsa050330.64307601
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63358355
69Purine metabolism_Homo sapiens_hsa002300.63309298
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59573065
71Tight junction_Homo sapiens_hsa045300.58071129
72Homologous recombination_Homo sapiens_hsa034400.55601104
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.54370731
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.54006362
75ECM-receptor interaction_Homo sapiens_hsa045120.53742870
76Ether lipid metabolism_Homo sapiens_hsa005650.53480080
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.53445392
78Vitamin B6 metabolism_Homo sapiens_hsa007500.53342172
79Alcoholism_Homo sapiens_hsa050340.51722847
80Renin secretion_Homo sapiens_hsa049240.51123581
81Basal cell carcinoma_Homo sapiens_hsa052170.50940138
82Hedgehog signaling pathway_Homo sapiens_hsa043400.48699256
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47758580
84Propanoate metabolism_Homo sapiens_hsa006400.37973874
85Bile secretion_Homo sapiens_hsa049760.36949323
86Thyroid hormone synthesis_Homo sapiens_hsa049180.35944121
87Viral myocarditis_Homo sapiens_hsa054160.35647334
88mRNA surveillance pathway_Homo sapiens_hsa030150.34703269
89Systemic lupus erythematosus_Homo sapiens_hsa053220.33399336
90Arachidonic acid metabolism_Homo sapiens_hsa005900.33113570
91RNA transport_Homo sapiens_hsa030130.32987939
92Glycerolipid metabolism_Homo sapiens_hsa005610.31636445
93MAPK signaling pathway_Homo sapiens_hsa040100.29145148
94Metabolic pathways_Homo sapiens_hsa011000.27499507
95Ovarian steroidogenesis_Homo sapiens_hsa049130.26219353
96Fatty acid elongation_Homo sapiens_hsa000620.25468929
97Fat digestion and absorption_Homo sapiens_hsa049750.25457812
98Insulin resistance_Homo sapiens_hsa049310.25207506
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23215120
100Cardiac muscle contraction_Homo sapiens_hsa042600.23160905

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