POM121L1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein polyubiquitination (GO:1902914)7.81937779
2gamma-aminobutyric acid transport (GO:0015812)6.37714214
3tachykinin receptor signaling pathway (GO:0007217)4.54277378
4response to pheromone (GO:0019236)4.38763810
5neuronal action potential propagation (GO:0019227)4.10413645
6copper ion homeostasis (GO:0055070)3.98481222
7limb bud formation (GO:0060174)3.89274288
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78550180
9regulation of mitotic spindle checkpoint (GO:1903504)3.78550180
10replication fork processing (GO:0031297)3.65726059
11retinal cone cell development (GO:0046549)3.56951546
12positive regulation of action potential (GO:0045760)3.55863896
13neural tube formation (GO:0001841)3.50510078
14behavioral response to nicotine (GO:0035095)3.50025211
15cornea development in camera-type eye (GO:0061303)3.44782599
16positive regulation of male gonad development (GO:2000020)3.44768915
17urinary tract smooth muscle contraction (GO:0014848)3.44768033
18positive regulation of vascular permeability (GO:0043117)3.44416615
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36394132
20somite development (GO:0061053)3.34106907
21retinal ganglion cell axon guidance (GO:0031290)3.31067642
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30993561
23neuron fate determination (GO:0048664)3.23845161
24negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22406625
25positive regulation of digestive system process (GO:0060456)3.21106423
26positive regulation of microtubule polymerization (GO:0031116)3.20171624
27response to nitrosative stress (GO:0051409)3.18800397
28regulation of male gonad development (GO:2000018)3.15903301
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15675204
30sodium-independent organic anion transport (GO:0043252)3.13712454
31cerebral cortex radially oriented cell migration (GO:0021799)3.13553450
32axonal fasciculation (GO:0007413)3.12035885
33respiratory chain complex IV assembly (GO:0008535)3.07092938
34negative regulation of heart rate (GO:0010459)3.03338748
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00364845
36pyrimidine nucleobase catabolic process (GO:0006208)2.95882847
37myeloid leukocyte mediated immunity (GO:0002444)2.95610096
38sympathetic nervous system development (GO:0048485)2.93358308
39righting reflex (GO:0060013)2.92176669
40behavioral response to ethanol (GO:0048149)2.92115207
41endocardial cushion morphogenesis (GO:0003203)2.90884263
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88212850
43olfactory bulb development (GO:0021772)2.86474153
44protein localization to cilium (GO:0061512)2.84148493
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84102745
46presynaptic membrane assembly (GO:0097105)2.83557787
47DNA ligation (GO:0006266)2.81998397
48prostate gland growth (GO:0060736)2.80834121
49DNA integration (GO:0015074)2.80781352
50regulation of action potential (GO:0098900)2.79756797
51regulation of timing of cell differentiation (GO:0048505)2.79546149
52positive regulation of uterine smooth muscle contraction (GO:0070474)2.77411597
53DNA double-strand break processing (GO:0000729)2.77091928
54cell wall macromolecule catabolic process (GO:0016998)2.75681254
55cytochrome complex assembly (GO:0017004)2.75079595
56response to auditory stimulus (GO:0010996)2.73778213
57spinal cord development (GO:0021510)2.73382286
58platelet dense granule organization (GO:0060155)2.69252995
59negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.68954625
60proline transport (GO:0015824)2.68869471
61neutrophil mediated immunity (GO:0002446)2.68333250
62protein complex biogenesis (GO:0070271)2.68263116
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66264536
64negative regulation of mast cell activation (GO:0033004)2.65783771
65epithelial cilium movement (GO:0003351)2.63676716
66intraciliary transport (GO:0042073)2.63145023
67L-fucose catabolic process (GO:0042355)2.62312208
68fucose catabolic process (GO:0019317)2.62312208
69L-fucose metabolic process (GO:0042354)2.62312208
70auditory behavior (GO:0031223)2.62182696
71regulation of uterine smooth muscle contraction (GO:0070472)2.61221143
72aldehyde catabolic process (GO:0046185)2.60696719
73aggressive behavior (GO:0002118)2.59392947
74regulation of hexokinase activity (GO:1903299)2.58521346
75regulation of glucokinase activity (GO:0033131)2.58521346
76resolution of meiotic recombination intermediates (GO:0000712)2.57318334
77positive regulation of oligodendrocyte differentiation (GO:0048714)2.56644492
78receptor guanylyl cyclase signaling pathway (GO:0007168)2.56573999
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56037660
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.54806785
81positive regulation of mRNA processing (GO:0050685)2.54069201
82mechanosensory behavior (GO:0007638)2.51483586
83protein-cofactor linkage (GO:0018065)2.47881846
84cellular ketone body metabolic process (GO:0046950)2.47456344
85cullin deneddylation (GO:0010388)2.46135219
86cGMP metabolic process (GO:0046068)2.45166557
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.44881262
88cAMP catabolic process (GO:0006198)2.44854542
89maturation of 5.8S rRNA (GO:0000460)2.43305597
90cerebral cortex cell migration (GO:0021795)2.43147599
91presynaptic membrane organization (GO:0097090)2.42867075
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.42096298
93mitochondrial respiratory chain complex assembly (GO:0033108)2.41192400
94positive regulation of mRNA 3-end processing (GO:0031442)2.40316118
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.38965725
96NADH dehydrogenase complex assembly (GO:0010257)2.38965725
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.38965725
98rRNA methylation (GO:0031167)2.38926464
99regulation of microtubule-based movement (GO:0060632)2.38562681
100centriole replication (GO:0007099)2.37770572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human3.52340125
2VDR_22108803_ChIP-Seq_LS180_Human3.14315886
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.99234667
4FUS_26573619_Chip-Seq_HEK293_Human2.97016899
5GBX2_23144817_ChIP-Seq_PC3_Human2.84484071
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79756785
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75974507
8ZNF274_21170338_ChIP-Seq_K562_Hela2.66023442
9EWS_26573619_Chip-Seq_HEK293_Human2.64534635
10EZH2_22144423_ChIP-Seq_EOC_Human2.55052821
11P300_19829295_ChIP-Seq_ESCs_Human2.39690638
12IGF1R_20145208_ChIP-Seq_DFB_Human2.28938905
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20385980
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18440264
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15869634
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14344816
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12683483
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00926791
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00058040
20ER_23166858_ChIP-Seq_MCF-7_Human1.94166674
21TOP2B_26459242_ChIP-Seq_MCF-7_Human1.84605132
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.83778757
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.80200417
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78630503
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74868140
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.74538252
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70750815
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69126506
29AR_25329375_ChIP-Seq_VCAP_Human1.67195288
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66178197
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63566488
32BCAT_22108803_ChIP-Seq_LS180_Human1.63327447
33CBP_20019798_ChIP-Seq_JUKART_Human1.62709736
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62709736
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62549300
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.53207989
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52239093
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48615475
39SMAD4_21799915_ChIP-Seq_A2780_Human1.47329963
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42786704
41RNF2_27304074_Chip-Seq_NSC_Mouse1.40986601
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38122706
43SOX2_19829295_ChIP-Seq_ESCs_Human1.36081966
44NANOG_19829295_ChIP-Seq_ESCs_Human1.36081966
45RUNX2_22187159_ChIP-Seq_PCA_Human1.35856090
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35654622
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.35127923
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33800535
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32368812
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32368812
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.31628187
52* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31270762
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31262471
54STAT3_23295773_ChIP-Seq_U87_Human1.30887860
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.30111557
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.27929133
57TCF4_23295773_ChIP-Seq_U87_Human1.26638696
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.25029528
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25029528
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23513409
61JUN_21703547_ChIP-Seq_K562_Human1.23099868
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.21813122
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21530630
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19200149
65REST_21632747_ChIP-Seq_MESCs_Mouse1.18959385
66TCF4_22108803_ChIP-Seq_LS180_Human1.17774196
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.17622610
68MYC_18940864_ChIP-ChIP_HL60_Human1.17559952
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16957403
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16500976
71SOX9_26525672_Chip-Seq_HEART_Mouse1.16117834
72AHR_22903824_ChIP-Seq_MCF-7_Human1.15944663
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.15829389
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15780154
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15550243
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.15457062
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15362644
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15272061
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.13676730
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11785764
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11496752
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11393723
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11302737
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10038518
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09711393
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.09189416
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08725113
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07700076
89TP53_22573176_ChIP-Seq_HFKS_Human1.07018085
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05730530
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04884431
92ELK1_19687146_ChIP-ChIP_HELA_Human1.04738550
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.04327383
94P53_22387025_ChIP-Seq_ESCs_Mouse1.03252461
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02687525
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.02209054
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98540161
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.98082324
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98061040
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97352121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after4.45180072
2MP0008877_abnormal_DNA_methylation3.76858087
3MP0005645_abnormal_hypothalamus_physiol3.69849072
4MP0001968_abnormal_touch/_nociception3.59215204
5MP0003880_abnormal_central_pattern3.55933511
6MP0001529_abnormal_vocalization2.97143194
7MP0003787_abnormal_imprinting2.91988608
8MP0006292_abnormal_olfactory_placode2.88812734
9MP0002735_abnormal_chemical_nociception2.83847185
10MP0001501_abnormal_sleep_pattern2.03831941
11MP0002938_white_spotting2.02041412
12MP0003121_genomic_imprinting1.94093715
13MP0002734_abnormal_mechanical_nocicepti1.92599006
14MP0009745_abnormal_behavioral_response1.90610150
15MP0000631_abnormal_neuroendocrine_gland1.89705269
16MP0008058_abnormal_DNA_repair1.87625764
17MP0003195_calcinosis1.83932143
18MP0008995_early_reproductive_senescence1.82460000
19MP0001485_abnormal_pinna_reflex1.82172418
20MP0010386_abnormal_urinary_bladder1.81786147
21MP0003136_yellow_coat_color1.79309100
22MP0008789_abnormal_olfactory_epithelium1.77650013
23MP0002277_abnormal_respiratory_mucosa1.76473959
24MP0002751_abnormal_autonomic_nervous1.69103826
25MP0002272_abnormal_nervous_system1.58761723
26MP0009384_cardiac_valve_regurgitation1.56065931
27MP0009046_muscle_twitch1.50409372
28MP0001984_abnormal_olfaction1.48279663
29MP0001970_abnormal_pain_threshold1.47355121
30MP0005551_abnormal_eye_electrophysiolog1.47035306
31MP0004742_abnormal_vestibular_system1.46257064
32MP0003718_maternal_effect1.45834436
33MP0008872_abnormal_physiological_respon1.44730225
34MP0006072_abnormal_retinal_apoptosis1.42125358
35MP0005187_abnormal_penis_morphology1.40129611
36MP0005253_abnormal_eye_physiology1.39964580
37MP0000049_abnormal_middle_ear1.39766443
38MP0003635_abnormal_synaptic_transmissio1.39195632
39MP0009780_abnormal_chondrocyte_physiolo1.35433166
40MP0002733_abnormal_thermal_nociception1.34606886
41MP0002102_abnormal_ear_morphology1.32498750
42MP0002067_abnormal_sensory_capabilities1.31907601
43MP0004270_analgesia1.29767814
44MP0003755_abnormal_palate_morphology1.24926980
45MP0003123_paternal_imprinting1.23985966
46MP0004924_abnormal_behavior1.23647326
47MP0005386_behavior/neurological_phenoty1.23647326
48MP0003122_maternal_imprinting1.23166767
49MP0005248_abnormal_Harderian_gland1.21457707
50MP0002009_preneoplasia1.19371036
51MP0004142_abnormal_muscle_tone1.19069755
52MP0002572_abnormal_emotion/affect_behav1.17893867
53MP0002233_abnormal_nose_morphology1.17201490
54MP0005410_abnormal_fertilization1.16613180
55MP0001486_abnormal_startle_reflex1.15267504
56MP0004885_abnormal_endolymph1.14364883
57MP0005379_endocrine/exocrine_gland_phen1.11931903
58MP0002064_seizures1.10368886
59MP0002163_abnormal_gland_morphology1.10036331
60MP0002063_abnormal_learning/memory/cond1.09990902
61MP0004145_abnormal_muscle_electrophysio1.08191362
62MP0005646_abnormal_pituitary_gland1.04159551
63MP0005423_abnormal_somatic_nervous1.02725980
64MP0004859_abnormal_synaptic_plasticity1.01883740
65MP0005394_taste/olfaction_phenotype0.98829664
66MP0005499_abnormal_olfactory_system0.98829664
67MP0000647_abnormal_sebaceous_gland0.98731272
68MP0010030_abnormal_orbit_morphology0.96998890
69MP0005174_abnormal_tail_pigmentation0.95832864
70MP0009250_abnormal_appendicular_skeleto0.94621661
71MP0000026_abnormal_inner_ear0.93672246
72MP0002638_abnormal_pupillary_reflex0.92429904
73MP0006276_abnormal_autonomic_nervous0.92301935
74MP0005085_abnormal_gallbladder_physiolo0.91855071
75MP0001346_abnormal_lacrimal_gland0.90591297
76MP0000778_abnormal_nervous_system0.88491653
77MP0000566_synostosis0.87201877
78MP0001881_abnormal_mammary_gland0.83525512
79MP0003878_abnormal_ear_physiology0.82675693
80MP0005377_hearing/vestibular/ear_phenot0.82675693
81MP0002557_abnormal_social/conspecific_i0.81275211
82MP0001929_abnormal_gametogenesis0.81167059
83MP0002282_abnormal_trachea_morphology0.80963594
84MP0003938_abnormal_ear_development0.79065839
85MP0003698_abnormal_male_reproductive0.78840673
86MP0001905_abnormal_dopamine_level0.78569611
87MP0000372_irregular_coat_pigmentation0.78487827
88MP0003137_abnormal_impulse_conducting0.73054013
89MP0000569_abnormal_digit_pigmentation0.72856389
90MP0002184_abnormal_innervation0.72610619
91MP0000627_abnormal_mammary_gland0.72316981
92MP0002234_abnormal_pharynx_morphology0.71326110
93MP0003937_abnormal_limbs/digits/tail_de0.70791278
94MP0002876_abnormal_thyroid_physiology0.70131152
95MP0003315_abnormal_perineum_morphology0.68949961
96MP0003119_abnormal_digestive_system0.67888843
97MP0000639_abnormal_adrenal_gland0.67662378
98MP0002177_abnormal_outer_ear0.66830583
99MP0004133_heterotaxia0.66693428
100MP0004215_abnormal_myocardial_fiber0.66643105

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)5.89892835
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.89892835
3Abnormality of alanine metabolism (HP:0010916)5.89892835
4Septo-optic dysplasia (HP:0100842)4.24444240
5True hermaphroditism (HP:0010459)3.67916229
6Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.46303287
7Optic nerve hypoplasia (HP:0000609)3.43486898
8Unilateral renal agenesis (HP:0000122)3.38370792
9Pancreatic fibrosis (HP:0100732)3.20573182
10Pancreatic cysts (HP:0001737)3.13908013
11Absent speech (HP:0001344)2.91868361
12Absent septum pellucidum (HP:0001331)2.81898215
13Medial flaring of the eyebrow (HP:0010747)2.78939877
14Abnormality of midbrain morphology (HP:0002418)2.75331398
15Molar tooth sign on MRI (HP:0002419)2.75331398
16Nephronophthisis (HP:0000090)2.72533184
17Intestinal atresia (HP:0011100)2.70250335
18Abnormality of the septum pellucidum (HP:0007375)2.66996559
19Lipid accumulation in hepatocytes (HP:0006561)2.54988171
20Abnormality of serum amino acid levels (HP:0003112)2.50505983
21Increased hepatocellular lipid droplets (HP:0006565)2.49691426
22Abnormality of the common coagulation pathway (HP:0010990)2.47389000
23Gait imbalance (HP:0002141)2.46825356
24Type II lissencephaly (HP:0007260)2.41662260
25Abnormality of the renal medulla (HP:0100957)2.32785850
26Hyperventilation (HP:0002883)2.31149269
27Breast aplasia (HP:0100783)2.30516354
28Hypoplasia of the fovea (HP:0007750)2.28697973
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.28697973
30Cerebellar dysplasia (HP:0007033)2.27356344
31Congenital primary aphakia (HP:0007707)2.26377711
32Thyroid-stimulating hormone excess (HP:0002925)2.25246105
33Abnormality of the labia minora (HP:0012880)2.25218115
34Drooling (HP:0002307)2.25176699
35Broad-based gait (HP:0002136)2.24725357
36Partial agenesis of the corpus callosum (HP:0001338)2.24480798
37Congenital stationary night blindness (HP:0007642)2.23792904
38Cellular immunodeficiency (HP:0005374)2.23587624
39Stomach cancer (HP:0012126)2.23324500
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23127724
41Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19366362
42Hemiparesis (HP:0001269)2.16339466
43Poor head control (HP:0002421)2.15799614
44Severe Myopia (HP:0011003)2.14123846
45Male pseudohermaphroditism (HP:0000037)2.13609831
46Neoplasm of the adrenal cortex (HP:0100641)2.13503231
47Depressed nasal tip (HP:0000437)2.12386824
48Postaxial foot polydactyly (HP:0001830)2.10682791
49Hepatoblastoma (HP:0002884)2.06976679
50Anosmia (HP:0000458)2.06961525
51Cystic liver disease (HP:0006706)2.04478178
52Dandy-Walker malformation (HP:0001305)2.02846315
53Excessive salivation (HP:0003781)2.02067013
54Erectile abnormalities (HP:0100639)2.01093676
55Furrowed tongue (HP:0000221)1.98311951
56Pendular nystagmus (HP:0012043)1.97453911
57Tubulointerstitial nephritis (HP:0001970)1.97293366
58Aplasia/Hypoplasia of the breasts (HP:0010311)1.96693315
59Fair hair (HP:0002286)1.95825955
60Nephrogenic diabetes insipidus (HP:0009806)1.93686277
61Small hand (HP:0200055)1.92683927
62Sclerocornea (HP:0000647)1.90719955
63Increased CSF lactate (HP:0002490)1.90585965
64Abnormality of the fovea (HP:0000493)1.89437121
65Neonatal short-limb short stature (HP:0008921)1.86765466
66Vaginal atresia (HP:0000148)1.85696903
67Maternal diabetes (HP:0009800)1.85222153
68Genital tract atresia (HP:0001827)1.84688984
69Epidermoid cyst (HP:0200040)1.84362949
70Adrenal hypoplasia (HP:0000835)1.84144400
71Progressive inability to walk (HP:0002505)1.84043113
72Renal Fanconi syndrome (HP:0001994)1.82716413
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.82698539
74Bony spicule pigmentary retinopathy (HP:0007737)1.81463777
75Postaxial hand polydactyly (HP:0001162)1.81101223
76Retinal dysplasia (HP:0007973)1.81066214
77Increased serum ferritin (HP:0003281)1.81043804
78Hypoplastic iliac wings (HP:0002866)1.80416520
79Congenital, generalized hypertrichosis (HP:0004540)1.79071982
80Long nose (HP:0003189)1.78761464
81Scrotal hypoplasia (HP:0000046)1.78707819
82Patellar aplasia (HP:0006443)1.78236793
83Abnormality of the vitreous humor (HP:0004327)1.77409280
84Inappropriate behavior (HP:0000719)1.76752521
85Focal motor seizures (HP:0011153)1.76318333
86Short foot (HP:0001773)1.75289792
87Abnormal respiratory epithelium morphology (HP:0012253)1.75121316
88Abnormal respiratory motile cilium morphology (HP:0005938)1.75121316
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.74184384
90Renal hypoplasia (HP:0000089)1.73907351
91Abnormality of the ileum (HP:0001549)1.72819672
92Astigmatism (HP:0000483)1.72704209
93Aqueductal stenosis (HP:0002410)1.72399433
94Hemivertebrae (HP:0002937)1.70517356
95Progressive macrocephaly (HP:0004481)1.70254921
96Protruding tongue (HP:0010808)1.70210900
97Mitochondrial inheritance (HP:0001427)1.70041981
98Renal dysplasia (HP:0000110)1.69926428
99Lissencephaly (HP:0001339)1.69837856
100Abnormal drinking behavior (HP:0030082)1.69828459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.44999874
2FRK4.11788254
3MAP4K23.19546664
4EPHA42.90795310
5MAPK132.65503864
6MARK12.62830190
7MKNK22.57861140
8PDK22.25679997
9MKNK12.25480034
10ZAK2.18546998
11PNCK2.13800762
12NUAK12.03928277
13UHMK11.81290910
14IRAK11.76612604
15BRSK21.71673566
16CASK1.63475623
17MAP3K21.60605932
18WEE11.54695532
19TSSK61.54250863
20ICK1.49149638
21ADRBK21.47589551
22DAPK21.46601642
23PLK31.45311113
24BUB11.44371572
25DYRK21.41911924
26VRK11.40241810
27BMPR1B1.30117154
28AKT21.27994045
29TNIK1.21119906
30MAPK151.20738713
31ERBB31.15201460
32MINK11.15169992
33YES11.13821625
34OXSR11.13369305
35PLK21.13003781
36BCR1.11688028
37PBK1.11553108
38STK31.11084460
39CAMKK21.10927316
40CSNK1G21.07729956
41PTK2B1.05212537
42MUSK1.04038853
43EPHA31.00086961
44PKN10.99838804
45CSNK1G30.98518205
46ACVR1B0.95232801
47PRKCE0.93570804
48PAK30.93346343
49IRAK20.87599223
50PRKCG0.87115167
51STK390.87061003
52GRK10.86758334
53ROCK10.86631972
54STK110.86038407
55CSNK1G10.84997778
56DYRK30.84301981
57FGFR20.83838090
58MAPKAPK50.78099557
59NTRK30.75807171
60CSNK1A1L0.71596174
61BRD40.70084849
62TRIM280.69101905
63INSRR0.67288421
64CDK30.62941315
65PRKG10.62572171
66CDK190.62364098
67VRK20.61678279
68PLK10.59950404
69ADRBK10.59439774
70DMPK0.58520113
71BCKDK0.58506981
72KIT0.58298581
73CAMK2A0.56805358
74STK40.56296685
75PLK40.52613709
76PINK10.52609764
77MAP3K120.50634791
78CDK80.50382326
79PRKG20.47791329
80WNK40.46889026
81CLK10.46028136
82CHEK20.45511596
83SRPK10.41129111
84CDK70.40348112
85TAF10.39989135
86CSNK1A10.39942723
87CCNB10.38978782
88NEK90.38713716
89NEK10.38569900
90CSNK1D0.37324744
91PRKACA0.36604665
92EIF2AK30.36324294
93CAMK10.33957354
94PRKACB0.31557550
95PRKAA10.30658066
96TIE10.30495248
97TGFBR10.29439529
98DYRK1B0.27768530
99ATR0.26421516
100RPS6KA50.25004399

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.22957493
2Phototransduction_Homo sapiens_hsa047442.85537008
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82204575
4Protein export_Homo sapiens_hsa030602.74268377
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58348700
6Nicotine addiction_Homo sapiens_hsa050332.35334485
7Oxidative phosphorylation_Homo sapiens_hsa001902.31799905
8Parkinsons disease_Homo sapiens_hsa050122.04648911
9Butanoate metabolism_Homo sapiens_hsa006501.99999010
10Taste transduction_Homo sapiens_hsa047421.94942312
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92457760
12RNA polymerase_Homo sapiens_hsa030201.89326973
13Basal transcription factors_Homo sapiens_hsa030221.83116800
14Vitamin B6 metabolism_Homo sapiens_hsa007501.76973630
15Huntingtons disease_Homo sapiens_hsa050161.73002576
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71595762
17Linoleic acid metabolism_Homo sapiens_hsa005911.68261616
18Homologous recombination_Homo sapiens_hsa034401.65138117
19Propanoate metabolism_Homo sapiens_hsa006401.63803750
20RNA degradation_Homo sapiens_hsa030181.60150379
21Fanconi anemia pathway_Homo sapiens_hsa034601.59645011
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57712258
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53012163
24Glutamatergic synapse_Homo sapiens_hsa047241.50146676
25Caffeine metabolism_Homo sapiens_hsa002321.46911556
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41426354
27Olfactory transduction_Homo sapiens_hsa047401.38485719
28Sulfur relay system_Homo sapiens_hsa041221.37820773
29Alzheimers disease_Homo sapiens_hsa050101.33718843
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33269668
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29960641
32GABAergic synapse_Homo sapiens_hsa047271.26828355
33Morphine addiction_Homo sapiens_hsa050321.26743435
34Non-homologous end-joining_Homo sapiens_hsa034501.20360301
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18288409
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17111084
37Regulation of autophagy_Homo sapiens_hsa041401.16228823
38Circadian entrainment_Homo sapiens_hsa047131.16193167
39Proteasome_Homo sapiens_hsa030501.13029516
40Asthma_Homo sapiens_hsa053101.09293366
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09282731
42Pyruvate metabolism_Homo sapiens_hsa006201.04255635
43Cardiac muscle contraction_Homo sapiens_hsa042601.03533997
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01579850
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99948447
46Renin-angiotensin system_Homo sapiens_hsa046140.99942753
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.99742561
48Purine metabolism_Homo sapiens_hsa002300.99662608
49Peroxisome_Homo sapiens_hsa041460.98998724
50Retinol metabolism_Homo sapiens_hsa008300.98264368
51Amphetamine addiction_Homo sapiens_hsa050310.96845480
52Calcium signaling pathway_Homo sapiens_hsa040200.96420430
53Ether lipid metabolism_Homo sapiens_hsa005650.96400171
54Oocyte meiosis_Homo sapiens_hsa041140.95893365
55Chemical carcinogenesis_Homo sapiens_hsa052040.95321577
56Fatty acid degradation_Homo sapiens_hsa000710.94100653
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91386517
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90235013
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89634284
60beta-Alanine metabolism_Homo sapiens_hsa004100.87337494
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83106561
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81034822
63Tryptophan metabolism_Homo sapiens_hsa003800.79125831
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72242910
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71000297
66cAMP signaling pathway_Homo sapiens_hsa040240.69581705
67Serotonergic synapse_Homo sapiens_hsa047260.68058114
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66337439
69Dopaminergic synapse_Homo sapiens_hsa047280.63673936
70Dorso-ventral axis formation_Homo sapiens_hsa043200.61863978
71Hedgehog signaling pathway_Homo sapiens_hsa043400.60393684
72RNA transport_Homo sapiens_hsa030130.59924063
73Fatty acid metabolism_Homo sapiens_hsa012120.58256628
74ABC transporters_Homo sapiens_hsa020100.57676822
75Spliceosome_Homo sapiens_hsa030400.57455015
76Glycerolipid metabolism_Homo sapiens_hsa005610.56070191
77Salivary secretion_Homo sapiens_hsa049700.54872130
78Axon guidance_Homo sapiens_hsa043600.54775622
79Basal cell carcinoma_Homo sapiens_hsa052170.53493270
80Circadian rhythm_Homo sapiens_hsa047100.53035352
81Steroid biosynthesis_Homo sapiens_hsa001000.51938961
82Ribosome_Homo sapiens_hsa030100.51605694
83Arachidonic acid metabolism_Homo sapiens_hsa005900.51275347
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49006549
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48470445
86Cocaine addiction_Homo sapiens_hsa050300.48434182
87Renin secretion_Homo sapiens_hsa049240.48047926
88mRNA surveillance pathway_Homo sapiens_hsa030150.46624995
89Histidine metabolism_Homo sapiens_hsa003400.44217455
90Type I diabetes mellitus_Homo sapiens_hsa049400.43866271
91Nucleotide excision repair_Homo sapiens_hsa034200.43182466
92Metabolic pathways_Homo sapiens_hsa011000.42364478
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.42253478
94Glutathione metabolism_Homo sapiens_hsa004800.41284793
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40536095
96p53 signaling pathway_Homo sapiens_hsa041150.38061782
97Long-term depression_Homo sapiens_hsa047300.37727539
98One carbon pool by folate_Homo sapiens_hsa006700.36524439
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.35959327
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34544478

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