POM121

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.39949019
2nuclear pore organization (GO:0006999)5.02549227
3pre-miRNA processing (GO:0031054)4.96683748
4mitotic sister chromatid cohesion (GO:0007064)4.85261047
5negative regulation of erythrocyte differentiation (GO:0045647)4.76153377
6regulation of histone H3-K27 methylation (GO:0061085)4.68135922
7protein localization to kinetochore (GO:0034501)4.23780946
8DNA unwinding involved in DNA replication (GO:0006268)4.18276641
9pore complex assembly (GO:0046931)4.09914445
10sister chromatid segregation (GO:0000819)4.02564063
11mitotic sister chromatid segregation (GO:0000070)3.97014639
12* mitotic nuclear envelope disassembly (GO:0007077)3.95646288
13glucocorticoid receptor signaling pathway (GO:0042921)3.84686668
14Golgi transport vesicle coating (GO:0048200)3.82189570
15COPI coating of Golgi vesicle (GO:0048205)3.82189570
16protein localization to chromosome, centromeric region (GO:0071459)3.79147846
17regulation of RNA export from nucleus (GO:0046831)3.76843620
18* nuclear envelope disassembly (GO:0051081)3.73158548
19* membrane disassembly (GO:0030397)3.73158548
20mitotic chromosome condensation (GO:0007076)3.68982878
21heterochromatin organization (GO:0070828)3.68299797
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.64598858
23positive regulation of chromosome segregation (GO:0051984)3.61225962
24intracellular estrogen receptor signaling pathway (GO:0030520)3.60462557
25negative regulation of histone methylation (GO:0031061)3.52384025
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48003807
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.47299993
28regulation of hippo signaling (GO:0035330)3.44263657
29cell-substrate adherens junction assembly (GO:0007045)3.39651377
30focal adhesion assembly (GO:0048041)3.39651377
31adherens junction assembly (GO:0034333)3.36040801
32corticosteroid receptor signaling pathway (GO:0031958)3.33245563
33regulation of spindle organization (GO:0090224)3.33101448
34mRNA stabilization (GO:0048255)3.30288366
35RNA stabilization (GO:0043489)3.30288366
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.27393741
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27393741
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27393741
39histone H4-K12 acetylation (GO:0043983)3.26848874
40positive regulation of gene expression, epigenetic (GO:0045815)3.24713162
41mannose metabolic process (GO:0006013)3.22816708
42apoptotic process involved in morphogenesis (GO:0060561)3.19995110
43negative regulation of mRNA processing (GO:0050686)3.19639435
44alternative mRNA splicing, via spliceosome (GO:0000380)3.18832886
45protein localization to chromosome (GO:0034502)3.17802023
46proline biosynthetic process (GO:0006561)3.16868949
47cytoplasmic mRNA processing body assembly (GO:0033962)3.15660210
48paraxial mesoderm development (GO:0048339)3.14972925
49negative regulation of mRNA metabolic process (GO:1903312)3.14972119
50embryonic process involved in female pregnancy (GO:0060136)3.14906810
51cellular response to epidermal growth factor stimulus (GO:0071364)3.13606341
52gene silencing by RNA (GO:0031047)3.11042236
53negative regulation of RNA splicing (GO:0033119)3.10814009
54histone lysine demethylation (GO:0070076)3.08211004
55nucleosome disassembly (GO:0006337)3.08062631
56protein-DNA complex disassembly (GO:0032986)3.08062631
57regulation of sister chromatid cohesion (GO:0007063)3.07099933
58dosage compensation (GO:0007549)3.04748656
59NLS-bearing protein import into nucleus (GO:0006607)3.04667408
60protein export from nucleus (GO:0006611)3.02506037
61modulation by virus of host process (GO:0019054)3.02303863
62* nuclear envelope organization (GO:0006998)3.01467212
63regulation of translational termination (GO:0006449)2.99518638
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99450359
65monoubiquitinated protein deubiquitination (GO:0035520)2.99262357
66DNA duplex unwinding (GO:0032508)2.98335841
67mitotic metaphase plate congression (GO:0007080)2.98003367
68histone H2A monoubiquitination (GO:0035518)2.97433846
69histone demethylation (GO:0016577)2.96921805
70gene silencing (GO:0016458)2.95945506
71DNA geometric change (GO:0032392)2.94800497
72regulation of nucleobase-containing compound transport (GO:0032239)2.94371877
73activation of Rac GTPase activity (GO:0032863)2.94215633
74regulation of mitotic spindle organization (GO:0060236)2.94161138
75histone H3-K4 methylation (GO:0051568)2.93343296
76positive regulation of cell cycle G2/M phase transition (GO:1902751)2.93041547
77positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.93041547
78regulation of NFAT protein import into nucleus (GO:0051532)2.92261959
79stress granule assembly (GO:0034063)2.91873042
80response to epidermal growth factor (GO:0070849)2.90142341
81peptidyl-lysine dimethylation (GO:0018027)2.89816450
82regulation of histone H3-K9 methylation (GO:0051570)2.86088535
83peptidyl-arginine omega-N-methylation (GO:0035247)2.85341001
84spliceosomal tri-snRNP complex assembly (GO:0000244)2.84969391
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83687608
86chromatin assembly (GO:0031497)2.83510217
87regulation of DNA endoreduplication (GO:0032875)2.82831992
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81729105
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81388362
90histone H3-K36 demethylation (GO:0070544)2.80540082
91histone H4 acetylation (GO:0043967)2.80024669
92DNA topological change (GO:0006265)2.79162690
93modulation by symbiont of host cellular process (GO:0044068)2.77612790
94regulation of mRNA stability (GO:0043488)2.77526223
95trophectodermal cell differentiation (GO:0001829)2.77465878
96regulation of chromosome segregation (GO:0051983)2.77358092
97DNA damage response, signal transduction resulting in transcription (GO:0042772)2.76916994
98positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75778600
99thymic T cell selection (GO:0045061)2.75367679
100histone H3-K9 demethylation (GO:0033169)2.75104509
101positive regulation of RNA splicing (GO:0033120)2.74764866
102DNA replication-dependent nucleosome organization (GO:0034723)2.74689456
103DNA replication-dependent nucleosome assembly (GO:0006335)2.74689456
104regulation of glucose import in response to insulin stimulus (GO:2001273)2.74563708
105peptidyl-arginine N-methylation (GO:0035246)2.74099953
106peptidyl-arginine methylation (GO:0018216)2.74099953
107response to laminar fluid shear stress (GO:0034616)2.73897134
108regulation of early endosome to late endosome transport (GO:2000641)2.71925966
109chromosome condensation (GO:0030261)2.71511613
110negative regulation of cell size (GO:0045792)2.71428619
111translesion synthesis (GO:0019985)2.70849563
112kinetochore organization (GO:0051383)2.70765497
113regulation of histone H3-K4 methylation (GO:0051569)2.70640599
114regulation of chromatin binding (GO:0035561)2.70057268
115mRNA splice site selection (GO:0006376)2.69127061
116histone H4-K16 acetylation (GO:0043984)2.68317796
117regulation of histone methylation (GO:0031060)2.67354986
118regulation of cholesterol homeostasis (GO:2000188)2.67276488
119histone H4-K5 acetylation (GO:0043981)2.66187537
120histone H4-K8 acetylation (GO:0043982)2.66187537
1213-UTR-mediated mRNA stabilization (GO:0070935)2.65942986
122sister chromatid cohesion (GO:0007062)2.65934787
123metaphase plate congression (GO:0051310)2.65775462
124chromatin silencing (GO:0006342)2.65574309
125positive regulation of DNA-dependent DNA replication (GO:2000105)2.65409349
126negative regulation of gene expression, epigenetic (GO:0045814)2.64645021
127protein dealkylation (GO:0008214)2.63824015
128protein demethylation (GO:0006482)2.63824015
129regulation of translational fidelity (GO:0006450)2.63692403
130regulation of telomere maintenance via telomerase (GO:0032210)2.63273559
131histone H2A acetylation (GO:0043968)2.62748313
132DNA conformation change (GO:0071103)2.62627631
133regulation of RNA stability (GO:0043487)2.62439310
134DNA replication checkpoint (GO:0000076)2.61642198
135* mRNA transport (GO:0051028)2.61322929
136histone lysine methylation (GO:0034968)2.61012758
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.60376870
138response to muramyl dipeptide (GO:0032495)2.60357302
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60232284
140positive regulation of nuclease activity (GO:0032075)2.58781711
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57994423
142poly(A)+ mRNA export from nucleus (GO:0016973)2.54319124
143snRNA metabolic process (GO:0016073)2.53452131
144negative regulation of histone modification (GO:0031057)2.50358091
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48779669
146cellular protein complex localization (GO:0034629)2.47403631
147cell-substrate junction assembly (GO:0007044)2.46598852
148maternal placenta development (GO:0001893)2.46283120
149regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43770380
150cellular response to interleukin-4 (GO:0071353)2.43728680
151modulation by virus of host morphology or physiology (GO:0019048)2.43381002
152histone H4 deacetylation (GO:0070933)2.42957213
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42478210
154positive regulation by host of viral transcription (GO:0043923)2.42473652
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40980922
156protein localization to endosome (GO:0036010)2.38026826
157positive regulation of gamma-delta T cell activation (GO:0046645)2.37861138
158negative regulation of myotube differentiation (GO:0010832)2.35703376
159positive regulation of histone deacetylation (GO:0031065)2.35440635
160regulation of nuclease activity (GO:0032069)2.35099248
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34947338
162positive thymic T cell selection (GO:0045059)2.34235181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.13472227
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.29961924
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.14576346
4MYC_22102868_ChIP-Seq_BL_Human3.94703563
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41154176
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22077674
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82458857
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65185277
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55225456
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.43837287
11CIITA_25753668_ChIP-Seq_RAJI_Human2.32286268
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29344714
13TCF7_22412390_ChIP-Seq_EML_Mouse2.21359732
14AR_21909140_ChIP-Seq_LNCAP_Human2.21302187
15LXR_22292898_ChIP-Seq_THP-1_Human2.19747361
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.19694659
17VDR_21846776_ChIP-Seq_THP-1_Human2.12982230
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.11989871
19KDM2B_26808549_Chip-Seq_DND41_Human2.10673183
20* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.06088305
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03278145
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02453386
23* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00297269
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.90576340
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90018162
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79498635
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78174086
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74703525
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69193471
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64564656
31* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62219505
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61383915
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58261522
34KDM5A_27292631_Chip-Seq_BREAST_Human1.57095196
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56264116
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54406653
37* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53640638
38ZNF263_19887448_ChIP-Seq_K562_Human1.52396590
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.51533466
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51052966
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.51030272
42UTX_26944678_Chip-Seq_JUKART_Human1.49560459
43* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47433349
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47301651
45XRN2_22483619_ChIP-Seq_HELA_Human1.47216821
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45769512
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43570234
48* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40318435
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39856673
50CLOCK_20551151_ChIP-Seq_293T_Human1.38332168
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37577356
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36992954
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.35950267
54SCL_19346495_ChIP-Seq_HPC-7_Human1.35400382
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34046544
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32059481
57P68_20966046_ChIP-Seq_HELA_Human1.30209880
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29521593
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28566510
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.27106122
61* MAF_26560356_Chip-Seq_TH1_Human1.25941397
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24128760
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23832843
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23034449
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22035629
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22002907
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21756562
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.20837616
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20179502
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19365663
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19301551
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18915738
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18170204
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.17577207
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17307658
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16959558
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16939207
78NCOR1_26117541_ChIP-Seq_K562_Human1.16291477
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16181472
80CHD1_26751641_Chip-Seq_LNCaP_Human1.15648600
81SMC4_20622854_ChIP-Seq_HELA_Human1.14833267
82KDM2B_26808549_Chip-Seq_K562_Human1.14227291
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.13298125
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13055235
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12330011
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11884994
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10275826
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09738117
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09672405
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08355073
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08182777
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07915481
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07811071
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05371824
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04504856
96MYB_26560356_Chip-Seq_TH1_Human1.04159634
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03384893
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02693869
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02550480
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01706403
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01681723
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.01614237
103TTF2_22483619_ChIP-Seq_HELA_Human0.99111775
104* ATF3_27146783_Chip-Seq_COLON_Human0.98195416
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98058033
106CREB1_26743006_Chip-Seq_LNCaP_Human0.98049349
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97880179
108* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97436284
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97418292
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96867785
111MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96766250
112VDR_24763502_ChIP-Seq_THP-1_Human0.96585702
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96547789
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.95228879
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.93399104
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93382492
117MAF_26560356_Chip-Seq_TH2_Human0.91304934
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90178036
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89170063
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88621200
121TFEB_21752829_ChIP-Seq_HELA_Human0.88439762
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87377762
123RACK7_27058665_Chip-Seq_MCF-7_Human0.87330421
124TP53_22127205_ChIP-Seq_IMR90_Human0.86412998
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86115206
126* GABP_19822575_ChIP-Seq_HepG2_Human0.85765992
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84914134
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84192325
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.83802396
130MYB_26560356_Chip-Seq_TH2_Human0.82106770
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81710298
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80483479
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79158037
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.78932046
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77182315
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77024826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.42483830
2MP0003111_abnormal_nucleus_morphology3.36957065
3MP0005451_abnormal_body_composition3.15082883
4MP0003077_abnormal_cell_cycle3.00021386
5MP0010094_abnormal_chromosome_stability2.97026670
6MP0005076_abnormal_cell_differentiation2.93717614
7MP0003693_abnormal_embryo_hatching2.70886777
8MP0004957_abnormal_blastocyst_morpholog2.63680369
9MP0003123_paternal_imprinting2.53186539
10MP0010352_gastrointestinal_tract_polyps2.43826115
11MP0003121_genomic_imprinting2.40911606
12MP0001730_embryonic_growth_arrest2.32722842
13MP0008877_abnormal_DNA_methylation2.15293317
14MP0000350_abnormal_cell_proliferation2.14057852
15MP0002396_abnormal_hematopoietic_system2.12764744
16MP0005409_darkened_coat_color2.11467626
17MP0002084_abnormal_developmental_patter2.01725596
18MP0008007_abnormal_cellular_replicative1.99003616
19MP0003787_abnormal_imprinting1.98645086
20MP0001672_abnormal_embryogenesis/_devel1.96362449
21MP0005380_embryogenesis_phenotype1.96362449
22MP0002009_preneoplasia1.94355069
23MP0002085_abnormal_embryonic_tissue1.90090786
24MP0001697_abnormal_embryo_size1.89909614
25MP0003984_embryonic_growth_retardation1.87148044
26MP0004197_abnormal_fetal_growth/weight/1.85982394
27MP0004808_abnormal_hematopoietic_stem1.85968507
28MP0010307_abnormal_tumor_latency1.85339790
29MP0002088_abnormal_embryonic_growth/wei1.84445475
30MP0001849_ear_inflammation1.81132710
31MP0003890_abnormal_embryonic-extraembry1.74809856
32MP0009278_abnormal_bone_marrow1.73516228
33MP0000678_abnormal_parathyroid_gland1.70024581
34MP0002086_abnormal_extraembryonic_tissu1.68770072
35MP0005058_abnormal_lysosome_morphology1.63898217
36MP0008260_abnormal_autophagy1.62516556
37MP0002653_abnormal_ependyma_morphology1.60231352
38MP0003705_abnormal_hypodermis_morpholog1.59824317
39MP0002249_abnormal_larynx_morphology1.58262983
40MP0003172_abnormal_lysosome_physiology1.58071492
41MP0003436_decreased_susceptibility_to1.54605913
42MP0005666_abnormal_adipose_tissue1.52308664
43MP0002080_prenatal_lethality1.52014182
44MP0008961_abnormal_basal_metabolism1.51807266
45MP0003122_maternal_imprinting1.51413185
46MP0003091_abnormal_cell_migration1.50736943
47MP0000428_abnormal_craniofacial_morphol1.48342890
48MP0009672_abnormal_birth_weight1.47540979
49MP0000537_abnormal_urethra_morphology1.47087415
50MP0001873_stomach_inflammation1.46128274
51MP0001545_abnormal_hematopoietic_system1.45987994
52MP0005397_hematopoietic_system_phenotyp1.45987994
53MP0003453_abnormal_keratinocyte_physiol1.45451178
54MP0000733_abnormal_muscle_development1.42478138
55MP0004381_abnormal_hair_follicle1.42000639
56MP0010030_abnormal_orbit_morphology1.40158354
57MP0004947_skin_inflammation1.37744046
58MP0003115_abnormal_respiratory_system1.36307032
59MP0000569_abnormal_digit_pigmentation1.35306743
60MP0003119_abnormal_digestive_system1.33717840
61MP0001348_abnormal_lacrimal_gland1.33596638
62MP0004858_abnormal_nervous_system1.32546337
63MP0008058_abnormal_DNA_repair1.32170842
64MP0008932_abnormal_embryonic_tissue1.30638843
65MP0009703_decreased_birth_body1.28778270
66MP0004264_abnormal_extraembryonic_tissu1.28531027
67MP0000003_abnormal_adipose_tissue1.28214728
68MP0002796_impaired_skin_barrier1.27995840
69MP0005375_adipose_tissue_phenotype1.26303693
70MP0003935_abnormal_craniofacial_develop1.24271962
71MP0009053_abnormal_anal_canal1.22934676
72MP0001293_anophthalmia1.21529301
73MP0000703_abnormal_thymus_morphology1.20278549
74MP0001915_intracranial_hemorrhage1.20264104
75MP0004233_abnormal_muscle_weight1.20023872
76MP0002166_altered_tumor_susceptibility1.18700761
77MP0002925_abnormal_cardiovascular_devel1.17496640
78MP0003861_abnormal_nervous_system1.16502247
79MP0003385_abnormal_body_wall1.15733533
80MP0000858_altered_metastatic_potential1.10711165
81MP0003567_abnormal_fetal_cardiomyocyte1.09121343
82MP0003937_abnormal_limbs/digits/tail_de1.08874891
83MP0005501_abnormal_skin_physiology1.08845446
84MP0003755_abnormal_palate_morphology1.08771452
85MP0010234_abnormal_vibrissa_follicle1.08138817
86MP0000313_abnormal_cell_death1.07960217
87MP0002722_abnormal_immune_system1.04027012
88MP0005623_abnormal_meninges_morphology1.02818677
89MP0000432_abnormal_head_morphology1.01692763
90MP0008438_abnormal_cutaneous_collagen1.01396503
91MP0009840_abnormal_foam_cell0.99765649
92MP0002210_abnormal_sex_determination0.99432045
93MP0002970_abnormal_white_adipose0.99268683
94MP0009931_abnormal_skin_appearance0.98832138
95MP0003763_abnormal_thymus_physiology0.97752644
96MP0000490_abnormal_crypts_of0.96969743
97MP0004185_abnormal_adipocyte_glucose0.96515339
98MP0002092_abnormal_eye_morphology0.94895645
99MP0008770_decreased_survivor_rate0.93637597
100MP0002116_abnormal_craniofacial_bone0.90950914
101MP0002060_abnormal_skin_morphology0.90800989
102MP0001929_abnormal_gametogenesis0.90306256
103MP0002932_abnormal_joint_morphology0.90185301
104MP0002019_abnormal_tumor_incidence0.89520435
105MP0002429_abnormal_blood_cell0.87087028
106MP0001346_abnormal_lacrimal_gland0.86356386
107MP0002398_abnormal_bone_marrow0.85347858
108MP0001286_abnormal_eye_development0.84807593
109MP0002111_abnormal_tail_morphology0.84765253
110MP0005621_abnormal_cell_physiology0.84266866
111MP0001853_heart_inflammation0.83256151
112MP0001145_abnormal_male_reproductive0.82998081
113MP0009333_abnormal_splenocyte_physiolog0.82504014
114MP0002697_abnormal_eye_size0.82356655
115MP0000266_abnormal_heart_morphology0.80449097
116MP0001784_abnormal_fluid_regulation0.79839054
117MP0006292_abnormal_olfactory_placode0.78360235
118MP0002114_abnormal_axial_skeleton0.78093186
119MP0003566_abnormal_cell_adhesion0.77709719
120MP0009115_abnormal_fat_cell0.77576286
121MP0003300_gastrointestinal_ulcer0.77571865
122MP0005384_cellular_phenotype0.76932169
123MP0000716_abnormal_immune_system0.76887394
124MP0000759_abnormal_skeletal_muscle0.76360930
125MP0003303_peritoneal_inflammation0.76306782
126MP0001216_abnormal_epidermal_layer0.74996422
127MP0000689_abnormal_spleen_morphology0.74744662
128MP0004087_abnormal_muscle_fiber0.74532448
129MP0000685_abnormal_immune_system0.74399861
130MP0004782_abnormal_surfactant_physiolog0.72778233
131MP0003656_abnormal_erythrocyte_physiolo0.72325247
132MP0002081_perinatal_lethality0.71885557
133MP0002405_respiratory_system_inflammati0.71588124
134MP0003942_abnormal_urinary_system0.71190228
135MP0000653_abnormal_sex_gland0.71135533
136MP0002877_abnormal_melanocyte_morpholog0.70521819
137MP0010630_abnormal_cardiac_muscle0.69089859
138MP0005394_taste/olfaction_phenotype0.68770832
139MP0005499_abnormal_olfactory_system0.68770832
140MP0002089_abnormal_postnatal_growth/wei0.67100084
141MP0000049_abnormal_middle_ear0.67061430
142MP0003943_abnormal_hepatobiliary_system0.65526368
143MP0005023_abnormal_wound_healing0.64197907

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.56107887
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56107887
3Abnormality of the fingertips (HP:0001211)3.36314416
4Ependymoma (HP:0002888)3.29673814
5Broad face (HP:0000283)3.16912763
6Volvulus (HP:0002580)3.09164303
7Long eyelashes (HP:0000527)3.06789749
8Increased nuchal translucency (HP:0010880)3.02711626
9Hyperacusis (HP:0010780)2.91937477
10Disproportionate tall stature (HP:0001519)2.79743536
11Trigonocephaly (HP:0000243)2.71708558
12Abnormality of the astrocytes (HP:0100707)2.68406436
13Astrocytoma (HP:0009592)2.68406436
14Dysmetric saccades (HP:0000641)2.60781172
15Abnormal gallbladder physiology (HP:0012438)2.58604177
16Cholecystitis (HP:0001082)2.58604177
17Facial hemangioma (HP:0000329)2.57668089
18Ulnar bowing (HP:0003031)2.57322036
19Renal duplication (HP:0000075)2.54459228
20Ectopic kidney (HP:0000086)2.50743643
21Deviation of the thumb (HP:0009603)2.46701904
22Abnormality of the 4th metacarpal (HP:0010012)2.46232659
23Prominent nose (HP:0000448)2.42583727
24Proximal placement of thumb (HP:0009623)2.42153552
25Heterotopia (HP:0002282)2.34427113
26Broad thumb (HP:0011304)2.33881698
27Ankyloglossia (HP:0010296)2.33305269
28Asymmetry of the thorax (HP:0001555)2.30429580
29Urethral obstruction (HP:0000796)2.28642412
30Distal lower limb amyotrophy (HP:0008944)2.28593002
31Shallow orbits (HP:0000586)2.27407665
32Overlapping toe (HP:0001845)2.27275066
33Medulloblastoma (HP:0002885)2.25663697
34Abnormality of the labia minora (HP:0012880)2.24735763
35Protrusio acetabuli (HP:0003179)2.23454875
36Selective tooth agenesis (HP:0001592)2.22168271
37Broad palm (HP:0001169)2.22071231
38Abnormal number of incisors (HP:0011064)2.20394297
39Patellar aplasia (HP:0006443)2.19099914
40Abnormality of oral frenula (HP:0000190)2.16789447
41Flat acetabular roof (HP:0003180)2.15649392
42Premature skin wrinkling (HP:0100678)2.12546042
43Reticulocytosis (HP:0001923)2.12258685
44Glioma (HP:0009733)2.11874982
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.11832402
46Neoplasm of the oral cavity (HP:0100649)2.11615064
47Skin tags (HP:0010609)2.08395071
48Abnormality of the columella (HP:0009929)2.06527202
49Macroorchidism (HP:0000053)2.03708817
50Deep venous thrombosis (HP:0002625)2.01616970
51Aplasia/Hypoplasia of the patella (HP:0006498)2.00930002
52Patellar dislocation (HP:0002999)2.00858649
53Hemorrhage of the eye (HP:0011885)2.00324124
54Cellulitis (HP:0100658)1.95997790
55Broad phalanges of the hand (HP:0009768)1.95293456
56Bowel incontinence (HP:0002607)1.94094331
57Supernumerary ribs (HP:0005815)1.93490278
58Renovascular hypertension (HP:0100817)1.92690618
59Narrow palate (HP:0000189)1.92687474
60Obsessive-compulsive behavior (HP:0000722)1.92592344
61Pseudobulbar signs (HP:0002200)1.92404065
62Abnormality of the thoracic spine (HP:0100711)1.91154151
63Insomnia (HP:0100785)1.90344008
64Overriding aorta (HP:0002623)1.89249622
65Elfin facies (HP:0004428)1.86416032
66Skull defect (HP:0001362)1.86311060
67Thin ribs (HP:0000883)1.85366676
68Abnormality of the intervertebral disk (HP:0005108)1.85044087
69Upper limb amyotrophy (HP:0009129)1.84733042
70Distal upper limb amyotrophy (HP:0007149)1.84733042
71Truncus arteriosus (HP:0001660)1.84419045
72Preauricular skin tag (HP:0000384)1.83359414
73Pointed chin (HP:0000307)1.82840155
74Seborrheic dermatitis (HP:0001051)1.82791119
75Atresia of the external auditory canal (HP:0000413)1.82511300
76Deep palmar crease (HP:0006191)1.82172461
77Neoplasm of striated muscle (HP:0009728)1.81890104
78Impulsivity (HP:0100710)1.81378221
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.81320963
80Basal cell carcinoma (HP:0002671)1.81156801
81Cutis marmorata (HP:0000965)1.79692019
82Increased connective tissue (HP:0009025)1.78952905
83Thin bony cortex (HP:0002753)1.78794450
84Broad finger (HP:0001500)1.77457755
85Papillary thyroid carcinoma (HP:0002895)1.77368355
86Biconcave vertebral bodies (HP:0004586)1.77334136
87Abnormal large intestine physiology (HP:0012700)1.77325090
88Progressive muscle weakness (HP:0003323)1.77131447
89Spina bifida occulta (HP:0003298)1.76861059
90Cerebral aneurysm (HP:0004944)1.76429717
91Truncal obesity (HP:0001956)1.76136592
92Cafe-au-lait spot (HP:0000957)1.75716876
93Fatigue (HP:0012378)1.75323574
94High pitched voice (HP:0001620)1.75188342
95Abnormality of the lower motor neuron (HP:0002366)1.74275110
96Abnormality of chromosome segregation (HP:0002916)1.74195054
97Increased density of long bones (HP:0006392)1.73537354
98Advanced eruption of teeth (HP:0006288)1.73375628
99Sandal gap (HP:0001852)1.72767159
100Slow saccadic eye movements (HP:0000514)1.72716383
101Anal stenosis (HP:0002025)1.72356401
102Neonatal hypoglycemia (HP:0001998)1.71884687
103Supernumerary bones of the axial skeleton (HP:0009144)1.71632781
104Oligodactyly (HP:0012165)1.71320788
105Achilles tendon contracture (HP:0001771)1.71159396
106Sacral dimple (HP:0000960)1.70882586
107Limited elbow extension (HP:0001377)1.70313711
108Segmental peripheral demyelination/remyelination (HP:0003481)1.69229207
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.68169165
110Sparse lateral eyebrow (HP:0005338)1.68006070
111Short 5th finger (HP:0009237)1.67934703
112Acute lymphatic leukemia (HP:0006721)1.67187407
113Bowel diverticulosis (HP:0005222)1.66516107
114Septate vagina (HP:0001153)1.65916425
115Germ cell neoplasia (HP:0100728)1.65672121
116Broad phalanx (HP:0006009)1.65043544
117Self-mutilation (HP:0000742)1.64781502
118Long palpebral fissure (HP:0000637)1.64768335
119Trismus (HP:0000211)1.64413605
120Neoplasm of the heart (HP:0100544)1.63890090
121Shawl scrotum (HP:0000049)1.63783785
122Metaphyseal cupping (HP:0003021)1.63545460
123Chromsome breakage (HP:0040012)1.62878329
124Arnold-Chiari malformation (HP:0002308)1.62561562
125Abnormality of the phalanges of the hallux (HP:0010057)1.61869888
126Short phalanx of the thumb (HP:0009660)1.61692981
127Lower limb amyotrophy (HP:0007210)1.61350210
128Hypoplastic labia majora (HP:0000059)1.61131520
129Dislocated radial head (HP:0003083)1.60978394
130Vertebral arch anomaly (HP:0008438)1.60810017
131Megalocornea (HP:0000485)1.60136555
132Persistence of primary teeth (HP:0006335)1.60114186
133Mitral regurgitation (HP:0001653)1.59951485
134Annular pancreas (HP:0001734)1.59922290
135Myopathic facies (HP:0002058)1.59635427
136Acute myeloid leukemia (HP:0004808)1.58923948
137Spinal muscular atrophy (HP:0007269)1.58198672
138Peripheral hypomyelination (HP:0007182)1.57846502
139Gastrointestinal carcinoma (HP:0002672)1.57522397
140Malignant gastrointestinal tract tumors (HP:0006749)1.57522397
141Progressive external ophthalmoplegia (HP:0000590)1.57360288
142Precocious puberty (HP:0000826)1.56934145
143Abnormality of the humeroradial joint (HP:0100744)1.55227727
144Obstructive sleep apnea (HP:0002870)1.54930929
145Increased IgE level (HP:0003212)1.54844511
146Syringomyelia (HP:0003396)1.53848386
147Spinal cord lesions (HP:0100561)1.53848386
148Thick eyebrow (HP:0000574)1.53734597
149Hypoplasia of the maxilla (HP:0000327)1.53213458
150Deep philtrum (HP:0002002)1.52969035
151Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.52809195
152Abnormality of the Achilles tendon (HP:0005109)1.52717274
153Aneurysm (HP:0002617)1.52543058
154Hypertensive crisis (HP:0100735)1.52423389
155Mitral valve prolapse (HP:0001634)1.52401006
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52122359
157Abnormality of the anterior horn cell (HP:0006802)1.51526400
158Degeneration of anterior horn cells (HP:0002398)1.51526400
159Intestinal malrotation (HP:0002566)1.51481730
160Genu recurvatum (HP:0002816)1.51159514
161Easy fatigability (HP:0003388)1.51127115
162Flat cornea (HP:0007720)1.50954845
163Birth length less than 3rd percentile (HP:0003561)1.50779369
164Premature rupture of membranes (HP:0001788)1.50518515
165Abnormality of the radial head (HP:0003995)1.50404070
166Turricephaly (HP:0000262)1.50293307
167High anterior hairline (HP:0009890)1.50128843
168Colitis (HP:0002583)1.45863101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.55202956
2SMG13.65186852
3PRPF4B3.53511059
4EEF2K3.49985953
5CDC73.44250675
6LATS13.43969149
7BRD42.78097478
8LATS22.74401343
9NEK22.73495377
10MAP3K102.46878782
11TRIB32.26789806
12ICK2.25259205
13FGFR42.20985267
14ALK1.84039705
15IRAK31.74881545
16TAOK11.74447868
17STK101.73315313
18STK31.72685885
19PKN21.66853950
20CAMK1G1.60933863
21MTOR1.57986441
22TTK1.55304904
23PRKD31.54942367
24STK38L1.54185619
25CDK41.45638814
26CHEK11.45124687
27TSSK61.42565259
28MAP2K31.42466209
29CAMK1D1.40378974
30CDK71.34052827
31MAP3K131.32176382
32KSR21.31132283
33MAP4K11.26200428
34SIK21.23793760
35ATR1.17806286
36PNCK1.17710672
37BUB11.15184162
38TYRO31.14853864
39CHEK21.12932043
40DMPK1.12454757
41RIPK41.12368596
42SIK31.11815730
43WEE11.08684423
44TAOK21.06523099
45NEK11.05811975
46CDK61.05404126
47PASK1.05383180
48CDK21.03613061
49PAK61.02291924
50PLK31.01262271
51MAPK111.00950992
52ATM1.00320607
53PLK10.99073060
54TTN0.96790007
55PLK40.93437575
56PAK20.93137103
57MKNK10.92119750
58MAP3K80.91528795
59CDK90.89873357
60FGFR30.88874351
61MAP3K140.85922192
62BMX0.82078168
63EPHB10.80099628
64PDGFRB0.77119118
65* CDK10.76537830
66PTK60.75877453
67PDGFRA0.75689711
68MAP3K10.75028537
69RPS6KA40.73816394
70RPS6KB20.73755505
71MELK0.72609148
72STK380.70261068
73MAP3K60.69715401
74CLK10.67672902
75CDK80.67301373
76AURKB0.66581380
77ZAP700.66013324
78PDPK10.64903020
79BRSK10.64484538
80CSNK1D0.64482919
81MKNK20.63692992
82MAP3K90.61374163
83CSNK1E0.60294180
84MAPK140.59720656
85SCYL20.58771295
86EPHA20.57880620
87PAK40.57376192
88MAP3K70.57249304
89GSK3B0.56852349
90FGFR10.56191184
91MARK20.55914591
92MAP3K30.55729855
93CHUK0.55515502
94MAPK120.55123386
95MAPK100.55085150
96MAP2K20.54496364
97MAP3K40.54222299
98ERN10.54143924
99STK40.52832876
100BRSK20.52826072
101IRAK20.49897860
102NME20.49628125
103RPS6KA20.48752808
104HIPK20.48731388
105PRKCH0.48716099
106NTRK10.47891715
107IRAK40.47071314
108MAPK10.47060171
109RPS6KL10.46795192
110RPS6KC10.46795192
111NTRK20.46554650
112MAPK80.46164358
113PRKDC0.45507456
114UHMK10.45414267
115PDK10.45040289
116LRRK20.44988023
117SIK10.44953985
118SRPK10.44216725
119JAK30.44099591
120PRKD20.43810439
121PIM10.43742388
122RAF10.42632120
123TESK20.41917676
124DYRK30.41823391
125SGK30.40881713
126AKT20.40853243
127BTK0.40080409
128AKT10.39393573
129PAK10.39062460
130EIF2AK10.38633518
131RPS6KA10.38538081
132TGFBR10.38190839
133CAMKK10.37853579
134RIPK10.37491283
135WNK10.37446920
136PTK20.37342067
137CDC42BPA0.37229439
138TYK20.36004857
139MAPK90.35669807
140AURKA0.35522349
141RET0.34591596
142MST1R0.34108136
143MAPKAPK20.33881271
144BRAF0.33527760
145GRK60.32160022

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.49423252
2* RNA transport_Homo sapiens_hsa030132.42159761
3mRNA surveillance pathway_Homo sapiens_hsa030152.29081412
4DNA replication_Homo sapiens_hsa030302.21442769
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16661393
6Spliceosome_Homo sapiens_hsa030402.12414937
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84327492
8Chronic myeloid leukemia_Homo sapiens_hsa052201.72787741
9Base excision repair_Homo sapiens_hsa034101.68382566
10Mismatch repair_Homo sapiens_hsa034301.64232220
11MicroRNAs in cancer_Homo sapiens_hsa052061.57972598
12Other glycan degradation_Homo sapiens_hsa005111.56258152
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55448285
14Notch signaling pathway_Homo sapiens_hsa043301.51210256
15Lysine degradation_Homo sapiens_hsa003101.48095444
16mTOR signaling pathway_Homo sapiens_hsa041501.41528033
17Oocyte meiosis_Homo sapiens_hsa041141.41138226
18RNA degradation_Homo sapiens_hsa030181.37872213
19Colorectal cancer_Homo sapiens_hsa052101.35348513
20Basal cell carcinoma_Homo sapiens_hsa052171.33609390
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33004826
22p53 signaling pathway_Homo sapiens_hsa041151.31538381
23HTLV-I infection_Homo sapiens_hsa051661.30140718
24Dorso-ventral axis formation_Homo sapiens_hsa043201.29958502
25Fanconi anemia pathway_Homo sapiens_hsa034601.26966101
26Adherens junction_Homo sapiens_hsa045201.26198750
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25961582
28Hippo signaling pathway_Homo sapiens_hsa043901.25147821
29One carbon pool by folate_Homo sapiens_hsa006701.22765000
30Non-small cell lung cancer_Homo sapiens_hsa052231.21834549
31Thyroid cancer_Homo sapiens_hsa052161.20946963
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.20025755
33Endometrial cancer_Homo sapiens_hsa052131.19124912
34Renal cell carcinoma_Homo sapiens_hsa052111.18426799
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17244785
36Homologous recombination_Homo sapiens_hsa034401.17192912
37Pancreatic cancer_Homo sapiens_hsa052121.15934305
38Pentose phosphate pathway_Homo sapiens_hsa000301.14907660
39Viral myocarditis_Homo sapiens_hsa054161.14829340
40Acute myeloid leukemia_Homo sapiens_hsa052211.14791886
41Hedgehog signaling pathway_Homo sapiens_hsa043401.14089190
42Small cell lung cancer_Homo sapiens_hsa052221.11502220
43Viral carcinogenesis_Homo sapiens_hsa052031.09211397
44Prion diseases_Homo sapiens_hsa050201.08258205
45Wnt signaling pathway_Homo sapiens_hsa043101.06795856
46Basal transcription factors_Homo sapiens_hsa030221.06287450
47Glioma_Homo sapiens_hsa052141.06014966
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05510303
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03609468
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02560950
51Fructose and mannose metabolism_Homo sapiens_hsa000511.01507118
52Epstein-Barr virus infection_Homo sapiens_hsa051691.01366141
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00327637
54Nucleotide excision repair_Homo sapiens_hsa034200.99413789
55Prostate cancer_Homo sapiens_hsa052150.99399088
56B cell receptor signaling pathway_Homo sapiens_hsa046620.98940270
57Non-homologous end-joining_Homo sapiens_hsa034500.98543245
58Biosynthesis of amino acids_Homo sapiens_hsa012300.97796321
59Influenza A_Homo sapiens_hsa051640.97411073
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96672513
61Proteoglycans in cancer_Homo sapiens_hsa052050.96027062
62Herpes simplex infection_Homo sapiens_hsa051680.94935513
63Hepatitis B_Homo sapiens_hsa051610.93967505
64TGF-beta signaling pathway_Homo sapiens_hsa043500.93839191
65ErbB signaling pathway_Homo sapiens_hsa040120.91360602
66T cell receptor signaling pathway_Homo sapiens_hsa046600.90904437
67VEGF signaling pathway_Homo sapiens_hsa043700.90236294
68Estrogen signaling pathway_Homo sapiens_hsa049150.89043376
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86647875
70Hepatitis C_Homo sapiens_hsa051600.85094869
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84871440
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.84317173
73Antigen processing and presentation_Homo sapiens_hsa046120.84222633
74Pathways in cancer_Homo sapiens_hsa052000.81174956
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.80400597
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.80205562
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80026018
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79110356
79GnRH signaling pathway_Homo sapiens_hsa049120.78885988
80Bladder cancer_Homo sapiens_hsa052190.78113314
81MAPK signaling pathway_Homo sapiens_hsa040100.76720723
82TNF signaling pathway_Homo sapiens_hsa046680.76577489
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75875626
84Prolactin signaling pathway_Homo sapiens_hsa049170.74125011
85Shigellosis_Homo sapiens_hsa051310.74060375
86FoxO signaling pathway_Homo sapiens_hsa040680.72988860
87RNA polymerase_Homo sapiens_hsa030200.70140527
88Type II diabetes mellitus_Homo sapiens_hsa049300.68961603
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67925162
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66131261
91Focal adhesion_Homo sapiens_hsa045100.65469666
92HIF-1 signaling pathway_Homo sapiens_hsa040660.64413780
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.64314302
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63818965
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63439251
96Toxoplasmosis_Homo sapiens_hsa051450.62394238
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61449033
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.61397976
99Long-term potentiation_Homo sapiens_hsa047200.61263441
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59941955
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59786044
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58602469
103Choline metabolism in cancer_Homo sapiens_hsa052310.56829301
104Apoptosis_Homo sapiens_hsa042100.56245982
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55648250
106Melanogenesis_Homo sapiens_hsa049160.55486301
107Primary immunodeficiency_Homo sapiens_hsa053400.54314253
108AMPK signaling pathway_Homo sapiens_hsa041520.53317324
109Insulin signaling pathway_Homo sapiens_hsa049100.53232464
110Amoebiasis_Homo sapiens_hsa051460.52911164
111Rap1 signaling pathway_Homo sapiens_hsa040150.52496179
112Tight junction_Homo sapiens_hsa045300.52150858
113Platelet activation_Homo sapiens_hsa046110.52086029
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52023512
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.51255756
116Axon guidance_Homo sapiens_hsa043600.51159714
117Leishmaniasis_Homo sapiens_hsa051400.51079418
118Insulin resistance_Homo sapiens_hsa049310.50979151
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50382736
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.50342921
121Glucagon signaling pathway_Homo sapiens_hsa049220.49069208
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48602950
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48320991
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48048646
125Osteoclast differentiation_Homo sapiens_hsa043800.47424252
126Endocytosis_Homo sapiens_hsa041440.47233799
127Inositol phosphate metabolism_Homo sapiens_hsa005620.46223857
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.46111297
129Measles_Homo sapiens_hsa051620.45155609

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