POLR2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.25501951
2ATP synthesis coupled proton transport (GO:0015986)7.25439902
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.25439902
4DNA deamination (GO:0045006)6.69307965
5chaperone-mediated protein transport (GO:0072321)6.63375250
6establishment of protein localization to mitochondrial membrane (GO:0090151)6.42297837
7ribosomal small subunit assembly (GO:0000028)6.27819484
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.22584043
9respiratory electron transport chain (GO:0022904)6.15062781
10electron transport chain (GO:0022900)6.02137038
11proteasome assembly (GO:0043248)5.27233070
12maturation of SSU-rRNA (GO:0030490)5.11996878
13viral transcription (GO:0019083)4.93302102
14ribosomal small subunit biogenesis (GO:0042274)4.85288050
15translational termination (GO:0006415)4.81670852
16ribosomal large subunit biogenesis (GO:0042273)4.79987435
17mitochondrial respiratory chain complex assembly (GO:0033108)4.61341379
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.56546899
19NADH dehydrogenase complex assembly (GO:0010257)4.56546899
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56546899
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.42796568
22rRNA modification (GO:0000154)4.34636930
23DNA replication checkpoint (GO:0000076)4.33486331
24cotranslational protein targeting to membrane (GO:0006613)4.29906809
25telomere maintenance via semi-conservative replication (GO:0032201)4.29276452
26protein targeting to ER (GO:0045047)4.28348042
27protein neddylation (GO:0045116)4.25349159
28translational elongation (GO:0006414)4.24390832
29ribonucleoprotein complex biogenesis (GO:0022613)4.22680441
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.16223806
31spliceosomal snRNP assembly (GO:0000387)4.10168226
32protein localization to endoplasmic reticulum (GO:0070972)4.07436261
33establishment of protein localization to mitochondrion (GO:0072655)4.06232450
34protein maturation by protein folding (GO:0022417)4.05660998
35translational initiation (GO:0006413)4.05047261
36* transcription elongation from RNA polymerase III promoter (GO:0006385)4.03333096
37* termination of RNA polymerase III transcription (GO:0006386)4.03333096
38protein targeting to membrane (GO:0006612)4.02020746
39establishment of protein localization to endoplasmic reticulum (GO:0072599)4.01825619
40ATP biosynthetic process (GO:0006754)4.00901384
41pseudouridine synthesis (GO:0001522)3.93662071
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.92593711
43DNA strand elongation involved in DNA replication (GO:0006271)3.92349883
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.91908728
45translation (GO:0006412)3.90725005
46telomere maintenance via recombination (GO:0000722)3.87760949
47protein localization to mitochondrion (GO:0070585)3.83942329
48hydrogen ion transmembrane transport (GO:1902600)3.83761006
49ribosome biogenesis (GO:0042254)3.83227140
50regulation of mitochondrial translation (GO:0070129)3.78846489
51viral life cycle (GO:0019058)3.77350301
52DNA strand elongation (GO:0022616)3.77259684
53rRNA processing (GO:0006364)3.77040706
54cellular protein complex disassembly (GO:0043624)3.75157152
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75128208
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70916777
57purine nucleobase biosynthetic process (GO:0009113)3.68403449
58cellular component biogenesis (GO:0044085)3.67833328
59establishment of integrated proviral latency (GO:0075713)3.67718300
60spliceosomal complex assembly (GO:0000245)3.66687325
61inner mitochondrial membrane organization (GO:0007007)3.65613134
62DNA replication initiation (GO:0006270)3.64494113
63rRNA metabolic process (GO:0016072)3.62790800
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61730531
65nucleobase biosynthetic process (GO:0046112)3.56552086
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56443411
67sequestering of actin monomers (GO:0042989)3.56434524
68ribonucleoside triphosphate biosynthetic process (GO:0009201)3.55807076
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.55283904
70CENP-A containing nucleosome assembly (GO:0034080)3.54849209
71establishment of viral latency (GO:0019043)3.50550200
72kinetochore assembly (GO:0051382)3.50461234
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50415293
74formation of translation preinitiation complex (GO:0001731)3.49816586
75viral mRNA export from host cell nucleus (GO:0046784)3.45903024
76chromatin remodeling at centromere (GO:0031055)3.44944021
77mitochondrial transport (GO:0006839)3.44248910
78telomere maintenance via telomere lengthening (GO:0010833)3.44193003
79* 7-methylguanosine mRNA capping (GO:0006370)3.42187532
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41912910
81mitotic recombination (GO:0006312)3.37900453
82* 7-methylguanosine RNA capping (GO:0009452)3.36306266
83* RNA capping (GO:0036260)3.36306266
84regulation of cellular amino acid metabolic process (GO:0006521)3.35985248
85rRNA methylation (GO:0031167)3.35227068
86negative regulation of ligase activity (GO:0051352)3.34760971
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34760971
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31509084
89proton transport (GO:0015992)3.29657258
90ribosome assembly (GO:0042255)3.29632523
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29275910
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29275910
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29275910
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28855690
95UTP biosynthetic process (GO:0006228)3.27819740
96maturation of 5.8S rRNA (GO:0000460)3.27471061
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25880274
98nucleoside triphosphate biosynthetic process (GO:0009142)3.23911716
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23861391
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23861391
101* transcription-coupled nucleotide-excision repair (GO:0006283)3.23838139
102protein complex disassembly (GO:0043241)3.22850430
103hydrogen transport (GO:0006818)3.21853297
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.20419034
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20419034
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19732013
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19687352
108metallo-sulfur cluster assembly (GO:0031163)3.18965338
109iron-sulfur cluster assembly (GO:0016226)3.18965338
110oxidative phosphorylation (GO:0006119)3.18170665
111signal transduction involved in cell cycle checkpoint (GO:0072395)3.17437758
112cytochrome complex assembly (GO:0017004)3.16896009
113mitotic metaphase plate congression (GO:0007080)3.16328017
114deoxyribonucleotide biosynthetic process (GO:0009263)3.16124918
115guanosine-containing compound biosynthetic process (GO:1901070)3.15640625
116regulation of nuclear cell cycle DNA replication (GO:0033262)3.14997577
117macromolecular complex disassembly (GO:0032984)3.13915531
118tRNA methylation (GO:0030488)3.12934797
119intracellular protein transmembrane import (GO:0044743)3.12595551
120DNA catabolic process, exonucleolytic (GO:0000738)3.12205878
121termination of RNA polymerase I transcription (GO:0006363)3.12195484
122mRNA catabolic process (GO:0006402)3.11892694
123respiratory chain complex IV assembly (GO:0008535)3.11334997
124L-methionine salvage (GO:0071267)3.10778887
125L-methionine biosynthetic process (GO:0071265)3.10778887
126amino acid salvage (GO:0043102)3.10778887
127kinetochore organization (GO:0051383)3.10561025
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09473685
129nucleobase-containing small molecule interconversion (GO:0015949)3.08281580
130base-excision repair, AP site formation (GO:0006285)3.07728409
131positive regulation of ligase activity (GO:0051351)3.07100195
132GTP biosynthetic process (GO:0006183)3.06146268
133protein complex biogenesis (GO:0070271)3.06047450
134nucleotide-excision repair, DNA gap filling (GO:0006297)3.04186105
135transcription elongation from RNA polymerase I promoter (GO:0006362)3.02186677
136protein targeting to mitochondrion (GO:0006626)3.01337017
137GDP-mannose metabolic process (GO:0019673)2.99837745
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.99301372
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98396277
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98396277
141establishment of protein localization to membrane (GO:0090150)2.98138230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.40985586
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37706846
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.28088541
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.02301601
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.94067235
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78214416
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.64996347
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.56746850
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24129782
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16673341
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96721989
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87175337
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86811089
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83735779
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80014679
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69722913
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67445271
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66246266
19VDR_23849224_ChIP-Seq_CD4+_Human2.65290259
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58652241
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57457313
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53447571
23* XRN2_22483619_ChIP-Seq_HELA_Human2.46106478
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41342758
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33000537
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30757905
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.27542068
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21359559
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20521949
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.17722464
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11500945
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.10780252
33GABP_19822575_ChIP-Seq_HepG2_Human2.09233293
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07821579
35TTF2_22483619_ChIP-Seq_HELA_Human2.02174664
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93839678
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91173866
38ELK1_19687146_ChIP-ChIP_HELA_Human1.90912896
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.78741959
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77539944
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77400211
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75542679
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73655543
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73429514
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67707102
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.67342081
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65291276
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65087832
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64261349
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63764313
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60934103
52ZNF263_19887448_ChIP-Seq_K562_Human1.57082319
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53198673
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51052922
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49789716
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49267891
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47189993
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45902499
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43548127
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.39883879
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38168211
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.37917563
63CIITA_25753668_ChIP-Seq_RAJI_Human1.37150915
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34606005
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33784940
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.31815838
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30611571
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28843362
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23053503
70MYC_18940864_ChIP-ChIP_HL60_Human1.22747346
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20421959
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.17603366
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17217706
74KDM5A_27292631_Chip-Seq_BREAST_Human1.16630255
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15213467
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14519081
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12421931
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10541606
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08517553
80SPI1_23547873_ChIP-Seq_NB4_Human1.08388319
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05479295
82AR_21909140_ChIP-Seq_LNCAP_Human1.03643176
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02745399
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02745033
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.01242913
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00400476
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00246233
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.00077825
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98414350
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96742224
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.95857202
92TRIM28_21343339_ChIP-Seq_HEK293_Human0.95564652
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94819414
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94507901
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92695940
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92331404
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92198875
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91280918
99* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91112405
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89406754
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88671263
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88118727
103* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86068665
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84514128
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84190789
106ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84014671
107* CTCF_20526341_ChIP-Seq_ESCs_Human0.83970105
108TFEB_21752829_ChIP-Seq_HELA_Human0.83877658
109* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83836606
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83673678
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.83480687
112* BCL6_27268052_Chip-Seq_Bcells_Human0.82518159
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82407663
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82339305
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81597452
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81369142
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78464513
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76465468
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76298899
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74271509
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.72697637
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71182371
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70951628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18457948
2MP0003111_abnormal_nucleus_morphology3.51683672
3MP0009379_abnormal_foot_pigmentation3.47901910
4MP0004957_abnormal_blastocyst_morpholog3.41167885
5MP0008058_abnormal_DNA_repair3.30026399
6MP0010094_abnormal_chromosome_stability3.26716714
7MP0003077_abnormal_cell_cycle3.06053935
8MP0008007_abnormal_cellular_replicative2.68885433
9MP0008932_abnormal_embryonic_tissue2.56680502
10MP0003186_abnormal_redox_activity2.48403450
11MP0008057_abnormal_DNA_replication2.41621774
12MP0003786_premature_aging2.39990237
13MP0003718_maternal_effect2.37961637
14MP0008438_abnormal_cutaneous_collagen2.10078470
15MP0002132_abnormal_respiratory_system2.09248064
16MP0006292_abnormal_olfactory_placode2.08562814
17MP0002938_white_spotting2.07992968
18MP0002837_dystrophic_cardiac_calcinosis2.04578448
19MP0005257_abnormal_intraocular_pressure2.00536934
20MP0002396_abnormal_hematopoietic_system1.98058340
21MP0000749_muscle_degeneration1.87187949
22MP0009333_abnormal_splenocyte_physiolog1.81154828
23MP0003941_abnormal_skin_development1.79921146
24MP0000490_abnormal_crypts_of1.77050737
25MP0000750_abnormal_muscle_regeneration1.72868481
26MP0001835_abnormal_antigen_presentation1.70826061
27MP0003950_abnormal_plasma_membrane1.70689852
28MP0005670_abnormal_white_adipose1.68471418
29MP0002295_abnormal_pulmonary_circulatio1.63128977
30MP0006036_abnormal_mitochondrial_physio1.59850890
31MP0003646_muscle_fatigue1.59086552
32MP0005503_abnormal_tendon_morphology1.56389459
33MP0003136_yellow_coat_color1.54727668
34MP0000343_altered_response_to1.53465851
35MP0003806_abnormal_nucleotide_metabolis1.53435939
36MP0001905_abnormal_dopamine_level1.50641462
37MP0009053_abnormal_anal_canal1.50047038
38MP0003011_delayed_dark_adaptation1.48065175
39MP0003315_abnormal_perineum_morphology1.48020555
40MP0002234_abnormal_pharynx_morphology1.45026656
41MP0001853_heart_inflammation1.44250684
42MP0009785_altered_susceptibility_to1.42572249
43MP0003724_increased_susceptibility_to1.42127329
44MP0002277_abnormal_respiratory_mucosa1.41979627
45MP0003283_abnormal_digestive_organ1.40396095
46MP0002160_abnormal_reproductive_system1.39343703
47MP0008789_abnormal_olfactory_epithelium1.39322391
48MP0002148_abnormal_hypersensitivity_rea1.37481388
49MP0005671_abnormal_response_to1.37362878
50MP0002653_abnormal_ependyma_morphology1.32302730
51MP0002163_abnormal_gland_morphology1.32257042
52MP0005075_abnormal_melanosome_morpholog1.30457143
53MP0000566_synostosis1.29768347
54MP0003123_paternal_imprinting1.28864140
55MP0005397_hematopoietic_system_phenotyp1.27379940
56MP0001545_abnormal_hematopoietic_system1.27379940
57MP0001188_hyperpigmentation1.27029181
58MP0001986_abnormal_taste_sensitivity1.24490159
59MP0000313_abnormal_cell_death1.24378601
60MP0005174_abnormal_tail_pigmentation1.20006663
61MP0009697_abnormal_copulation1.19405022
62MP0000350_abnormal_cell_proliferation1.18425762
63MP0003656_abnormal_erythrocyte_physiolo1.17769197
64MP0005389_reproductive_system_phenotype1.16666028
65MP0001119_abnormal_female_reproductive1.16125662
66MP0000751_myopathy1.15814378
67MP0003436_decreased_susceptibility_to1.15698416
68MP0003763_abnormal_thymus_physiology1.15552167
69MP0001764_abnormal_homeostasis1.14993216
70MP0006072_abnormal_retinal_apoptosis1.13972479
71MP0002095_abnormal_skin_pigmentation1.13232075
72MP0002736_abnormal_nociception_after1.13194233
73MP0000015_abnormal_ear_pigmentation1.12475701
74MP0009250_abnormal_appendicular_skeleto1.12408528
75MP0002019_abnormal_tumor_incidence1.11884535
76MP0002210_abnormal_sex_determination1.11598768
77MP0002282_abnormal_trachea_morphology1.11149907
78MP0000858_altered_metastatic_potential1.10126999
79MP0005330_cardiomyopathy1.09299165
80MP0000372_irregular_coat_pigmentation1.08275051
81MP0000762_abnormal_tongue_morphology1.08094414
82MP0003279_aneurysm1.08006343
83MP0001293_anophthalmia1.06300415
84MP0008875_abnormal_xenobiotic_pharmacok1.06014238
85MP0002638_abnormal_pupillary_reflex1.05789800
86MP0005165_increased_susceptibility_to1.05619080
87MP0001529_abnormal_vocalization1.05348484
88MP0008877_abnormal_DNA_methylation1.04008883
89MP0004147_increased_porphyrin_level1.02630407
90MP0002398_abnormal_bone_marrow1.02248510
91MP0005084_abnormal_gallbladder_morpholo1.02140524
92MP0005025_abnormal_response_to1.00487983
93MP0008260_abnormal_autophagy1.00421350
94MP0006035_abnormal_mitochondrial_morpho1.00172616
95MP0005508_abnormal_skeleton_morphology1.00138591
96MP0001542_abnormal_bone_strength0.99588588
97MP0001919_abnormal_reproductive_system0.99515180
98MP0002102_abnormal_ear_morphology0.98834026
99MP0004272_abnormal_basement_membrane0.98367888
100MP0002722_abnormal_immune_system0.94750120
101MP0000689_abnormal_spleen_morphology0.94274831
102MP0000613_abnormal_salivary_gland0.94007540
103MP0001730_embryonic_growth_arrest0.93680379
104MP0005197_abnormal_uvea_morphology0.92292711
105MP0005058_abnormal_lysosome_morphology0.91187608
106MP0001879_abnormal_lymphatic_vessel0.91157145
107MP0002429_abnormal_blood_cell0.89025411
108MP0005332_abnormal_amino_acid0.88720814
109MP0005000_abnormal_immune_tolerance0.88315471
110MP0001881_abnormal_mammary_gland0.87446463
111MP0001145_abnormal_male_reproductive0.85720116
112MP0000049_abnormal_middle_ear0.84975148
113MP0004808_abnormal_hematopoietic_stem0.84776472
114MP0000703_abnormal_thymus_morphology0.83873952
115MP0009840_abnormal_foam_cell0.83756455
116MP0003828_pulmonary_edema0.83309526
117MP0002452_abnormal_antigen_presenting0.83013535
118MP0002420_abnormal_adaptive_immunity0.82431752
119MP0001819_abnormal_immune_cell0.82283265
120MP0001346_abnormal_lacrimal_gland0.82173891
121MP0002723_abnormal_immune_serum0.81714792
122MP0000716_abnormal_immune_system0.81492651
123MP0005193_abnormal_anterior_eye0.80853581
124MP0003567_abnormal_fetal_cardiomyocyte0.80496183
125MP0000685_abnormal_immune_system0.80482523
126MP0002080_prenatal_lethality0.80214379
127MP0008469_abnormal_protein_level0.79963619
128MP0000358_abnormal_cell_content/0.79909419
129MP0010030_abnormal_orbit_morphology0.79514468
130MP0008995_early_reproductive_senescence0.79372132
131MP0004142_abnormal_muscle_tone0.78611424
132MP0002419_abnormal_innate_immunity0.78032345
133MP0001697_abnormal_embryo_size0.77151922
134MP0004510_myositis0.77145906
135MP0000653_abnormal_sex_gland0.76798646
136MP0001672_abnormal_embryogenesis/_devel0.76067224
137MP0005380_embryogenesis_phenotype0.76067224
138MP0004381_abnormal_hair_follicle0.75958637
139MP0001727_abnormal_embryo_implantation0.75169665
140MP0005501_abnormal_skin_physiology0.73867767
141MP0005360_urolithiasis0.72658955
142MP0002177_abnormal_outer_ear0.72256839
143MP0005408_hypopigmentation0.72116712
144MP0001800_abnormal_humoral_immune0.71118681
145MP0001929_abnormal_gametogenesis0.71022747
146MP0001299_abnormal_eye_distance/0.70603511
147MP0010386_abnormal_urinary_bladder0.70441245
148MP0005171_absent_coat_pigmentation0.69864949
149MP0003942_abnormal_urinary_system0.68761092
150MP0003638_abnormal_response/metabolism_0.68462737
151MP0005379_endocrine/exocrine_gland_phen0.65674212
152MP0010368_abnormal_lymphatic_system0.65164812
153MP0009384_cardiac_valve_regurgitation0.63974572
154MP0005410_abnormal_fertilization0.63190734
155MP0004133_heterotaxia0.62576167
156MP0001756_abnormal_urination0.62332986
157MP0005623_abnormal_meninges_morphology0.60691833
158MP0000537_abnormal_urethra_morphology0.60624706
159MP0000163_abnormal_cartilage_morphology0.59238835
160MP0001243_abnormal_dermal_layer0.59025101
161MP0003938_abnormal_ear_development0.57969083

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.69178823
2Abnormal number of erythroid precursors (HP:0012131)4.64375046
3Abnormality of cells of the erythroid lineage (HP:0012130)4.52487002
4Birth length less than 3rd percentile (HP:0003561)3.90204853
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85544065
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85544065
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.81510883
8Hepatocellular necrosis (HP:0001404)3.76836723
9Mitochondrial inheritance (HP:0001427)3.73828085
10Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.69221560
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.63088682
12Increased hepatocellular lipid droplets (HP:0006565)3.50906188
13Acute necrotizing encephalopathy (HP:0006965)3.50542688
143-Methylglutaconic aciduria (HP:0003535)3.48621074
15Aplastic anemia (HP:0001915)3.47798430
16Increased CSF lactate (HP:0002490)3.46670021
17Macrocytic anemia (HP:0001972)3.45244925
18Hepatic necrosis (HP:0002605)3.44971869
19Breast hypoplasia (HP:0003187)3.43200306
20Increased serum lactate (HP:0002151)3.29171213
21Exertional dyspnea (HP:0002875)3.28074310
22Oral leukoplakia (HP:0002745)3.27568352
23Abnormal mitochondria in muscle tissue (HP:0008316)3.22657276
24Pallor (HP:0000980)3.19958553
25Type I transferrin isoform profile (HP:0003642)3.18905248
26Lipid accumulation in hepatocytes (HP:0006561)3.16228251
27Type 2 muscle fiber atrophy (HP:0003554)3.07617443
28Muscle fiber atrophy (HP:0100295)2.97255167
29Renal Fanconi syndrome (HP:0001994)2.91134573
30Rough bone trabeculation (HP:0100670)2.85111862
31Acute encephalopathy (HP:0006846)2.83332564
32Chromsome breakage (HP:0040012)2.81358629
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75472586
34Carpal bone hypoplasia (HP:0001498)2.71819677
35Microvesicular hepatic steatosis (HP:0001414)2.68954014
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.68004434
37Progressive macrocephaly (HP:0004481)2.67492181
38Respiratory difficulties (HP:0002880)2.65139200
39Leukodystrophy (HP:0002415)2.62627220
40Lactic acidosis (HP:0003128)2.61484981
41Increased intramyocellular lipid droplets (HP:0012240)2.59768250
42Optic disc pallor (HP:0000543)2.59577320
43Exercise intolerance (HP:0003546)2.59293504
44Cerebral hypomyelination (HP:0006808)2.54653068
45Meckel diverticulum (HP:0002245)2.54275764
46Reduced antithrombin III activity (HP:0001976)2.53804051
47Pancytopenia (HP:0001876)2.51771725
48Aplasia/Hypoplasia of the patella (HP:0006498)2.49539551
49Patellar aplasia (HP:0006443)2.46012536
50Abnormality of the preputium (HP:0100587)2.44754834
51Poor head control (HP:0002421)2.42592773
52Secondary amenorrhea (HP:0000869)2.42469701
53Respiratory failure (HP:0002878)2.42149681
54Degeneration of anterior horn cells (HP:0002398)2.38497831
55Abnormality of the anterior horn cell (HP:0006802)2.38497831
56Abnormality of the ileum (HP:0001549)2.38325013
57Absent thumb (HP:0009777)2.34188911
58Thrombocytosis (HP:0001894)2.34108383
59Aplasia/hypoplasia of the uterus (HP:0008684)2.33677246
60Sparse eyelashes (HP:0000653)2.32963901
61Progressive muscle weakness (HP:0003323)2.31566812
62Cleft eyelid (HP:0000625)2.29665799
63Abnormality of alanine metabolism (HP:0010916)2.26168604
64Hyperalaninemia (HP:0003348)2.26168604
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26168604
66Microretrognathia (HP:0000308)2.25820853
67Increased muscle lipid content (HP:0009058)2.23330859
68Horseshoe kidney (HP:0000085)2.19644243
69Abnormality of urine glucose concentration (HP:0011016)2.19470843
70Glycosuria (HP:0003076)2.19470843
71Emotional lability (HP:0000712)2.17526261
72Amniotic constriction ring (HP:0009775)2.17238146
73Abnormality of placental membranes (HP:0011409)2.17238146
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17146484
75Hyperphosphaturia (HP:0003109)2.16819239
76Generalized aminoaciduria (HP:0002909)2.15647294
77Triphalangeal thumb (HP:0001199)2.15572573
78Delayed CNS myelination (HP:0002188)2.12169970
79Methylmalonic aciduria (HP:0012120)2.11626347
80Abnormal protein glycosylation (HP:0012346)2.10813975
81Abnormal glycosylation (HP:0012345)2.10813975
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10813975
83Abnormal protein N-linked glycosylation (HP:0012347)2.10813975
84Increased serum pyruvate (HP:0003542)2.09780434
85Abnormal spermatogenesis (HP:0008669)2.09674939
86Premature graying of hair (HP:0002216)2.09201930
87Bone marrow hypocellularity (HP:0005528)2.08304668
88Progressive external ophthalmoplegia (HP:0000590)2.06650351
89Trismus (HP:0000211)2.06564178
90Abnormal trabecular bone morphology (HP:0100671)2.06291925
91X-linked dominant inheritance (HP:0001423)2.04185879
92Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03116960
93Petechiae (HP:0000967)2.02253603
94Opisthotonus (HP:0002179)2.00721492
95Partial duplication of the phalanx of hand (HP:0009999)2.00589554
9611 pairs of ribs (HP:0000878)1.99795554
97CNS demyelination (HP:0007305)1.99391311
98Abnormality of chromosome stability (HP:0003220)1.99313561
99Cerebral edema (HP:0002181)1.96331030
100Premature ovarian failure (HP:0008209)1.96245736
101Premature rupture of membranes (HP:0001788)1.95282707
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.91507022
103Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90796650
104Congenital, generalized hypertrichosis (HP:0004540)1.90659708
105Blindness (HP:0000618)1.87670725
106Nausea (HP:0002018)1.87581424
107Reduced subcutaneous adipose tissue (HP:0003758)1.87267972
108Redundant skin (HP:0001582)1.82111441
109Pancreatic cysts (HP:0001737)1.81837585
110Abnormality of renal resorption (HP:0011038)1.80682315
111Myelodysplasia (HP:0002863)1.80376148
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80062562
113Abnormality of glycolysis (HP:0004366)1.79507537
114Dicarboxylic aciduria (HP:0003215)1.78799050
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78799050
116Testicular atrophy (HP:0000029)1.77099039
117Partial duplication of thumb phalanx (HP:0009944)1.77051726
118Lethargy (HP:0001254)1.75713414
119Concave nail (HP:0001598)1.74757883
120Hyperglycinemia (HP:0002154)1.74558817
121Pulmonary fibrosis (HP:0002206)1.73953073
122Multiple enchondromatosis (HP:0005701)1.73682628
123Cellular immunodeficiency (HP:0005374)1.71468066
124Absent radius (HP:0003974)1.70758148
125Hypoplasia of the radius (HP:0002984)1.69752010
126Abnormal pupillary function (HP:0007686)1.68484315
127Congenital ichthyosiform erythroderma (HP:0007431)1.67949597
128Methylmalonic acidemia (HP:0002912)1.63990292
129Abnormal urine phosphate concentration (HP:0012599)1.63910644
130Sclerocornea (HP:0000647)1.63306572
131Renal tubular dysfunction (HP:0000124)1.61639706
132Respiratory insufficiency due to muscle weakness (HP:0002747)1.61521102
133Adrenal hypoplasia (HP:0000835)1.61330816
134Vertebral compression fractures (HP:0002953)1.59530438
135Vomiting (HP:0002013)1.58767572
136Generalized amyotrophy (HP:0003700)1.56824806
137Prolonged neonatal jaundice (HP:0006579)1.56226824
138Abnormal number of incisors (HP:0011064)1.54565485
139Nasolacrimal duct obstruction (HP:0000579)1.47960693
140Decreased subcutaneous fat (HP:0001002)1.45682509
141Joint stiffness (HP:0001387)1.45428930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.10391036
2TLK14.21044672
3EIF2AK13.96435352
4BUB13.85203650
5NME23.58696101
6STK163.36803503
7IRAK33.31562541
8LIMK12.98507315
9PLK42.98229415
10WEE12.95848337
11SRPK12.91182729
12ZAK2.26975184
13PIM22.22224692
14IRAK42.09816479
15MKNK22.07997911
16VRK12.05195092
17EIF2AK31.87757844
18DYRK31.71834025
19EPHB21.69932339
20TESK21.56304953
21MKNK11.49562920
22CDK191.45514047
23BCKDK1.45136120
24BRSK21.43918291
25TSSK61.43688075
26NME11.41570387
27PLK11.38393658
28NEK91.33247267
29ACVR1B1.30846060
30CDC71.26185761
31CDK81.24123122
32IRAK11.23635567
33KDR1.23621940
34PBK1.15317230
35PINK11.14956562
36RPS6KA41.14293375
37TTK1.10841139
38CDK71.09217741
39LRRK21.09055173
40AURKB1.07309278
41BRAF1.05656962
42MAP3K111.03550720
43ABL21.00658933
44AURKA1.00417778
45PLK30.98645060
46EIF2AK20.98287240
47STK38L0.97674869
48GRK70.97493587
49TAOK20.97169860
50IRAK20.97108408
51NEK20.94312851
52TAF10.92118331
53ATR0.90708984
54CCNB10.89148533
55MOS0.85647552
56BRSK10.85540687
57MUSK0.83857731
58DAPK10.82146326
59AKT30.80723094
60PDK20.80193995
61IKBKB0.79427084
62PIM10.78157220
63TXK0.77487601
64PHKG20.76690421
65PHKG10.76690421
66TGFBR20.75863869
67DYRK20.75336293
68BLK0.75120302
69CASK0.74731250
70CSNK1G30.74657924
71CHEK20.72865505
72TEC0.72397620
73NEK10.72025783
74CSNK2A10.70972838
75GRK50.69278763
76EPHA20.67617921
77TESK10.66335864
78STK40.64216956
79RPS6KB20.61296058
80ADRBK10.60957481
81MAP2K70.60789896
82GRK10.59848425
83LMTK20.58989543
84MYLK0.58053277
85YES10.54805587
86CSNK2A20.54756104
87DAPK30.53275124
88PTK20.53120538
89MAP3K80.53020666
90PRKCI0.52560046
91ADRBK20.51701772
92ERBB40.49626471
93NLK0.49497268
94RPS6KA50.48600390
95CSNK1G10.47731642
96MAP3K140.46525572
97CAMK2G0.45480751
98BTK0.44426837
99MAP3K120.43857659
100TYK20.41679361
101CSNK1G20.41640686
102STK100.41516588
103MST1R0.40909866
104IKBKE0.40348669
105CSNK1A1L0.39854159
106KIT0.38846101
107CDK40.37806753
108TNIK0.36471603
109TIE10.36029970
110TBK10.36021014
111PRKG20.35804285
112LYN0.34572711
113MAPKAPK30.34184239
114PAK10.33871355
115ILK0.33809596
116NUAK10.33374732
117MAP2K60.33155512
118JAK30.32118939
119MST40.32110501
120GSK3A0.31859078
121ZAP700.31622242
122PIK3CG0.31149069
123PAK40.31137489
124CHEK10.31095492
125PTK2B0.30883976
126MAP4K10.30573159
127OBSCN0.30267095
128ATM0.30253659
129ARAF0.29510353
130CDK20.27253940
131CDK11A0.27206451
132PAK20.26206387
133CAMK2D0.25913518
134CDK140.24739558
135MAP4K20.24131283
136AKT20.23863813
137MAP3K30.22104460
138CSNK1A10.20553312
139PRKD20.20217027
140SCYL20.19521860
141CDK150.18804121

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.96282799
2Proteasome_Homo sapiens_hsa030504.10165340
3DNA replication_Homo sapiens_hsa030304.08668300
4* RNA polymerase_Homo sapiens_hsa030203.86801231
5Mismatch repair_Homo sapiens_hsa034303.25115476
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20349818
7Homologous recombination_Homo sapiens_hsa034402.89570269
8* Pyrimidine metabolism_Homo sapiens_hsa002402.87214784
9Spliceosome_Homo sapiens_hsa030402.82247096
10Base excision repair_Homo sapiens_hsa034102.58108580
11Nucleotide excision repair_Homo sapiens_hsa034202.41116294
12Oxidative phosphorylation_Homo sapiens_hsa001902.25801038
13RNA transport_Homo sapiens_hsa030132.19063283
14Protein export_Homo sapiens_hsa030602.15555306
15Parkinsons disease_Homo sapiens_hsa050122.08211592
16Fanconi anemia pathway_Homo sapiens_hsa034602.04306105
17* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02813409
18Basal transcription factors_Homo sapiens_hsa030221.89980971
19One carbon pool by folate_Homo sapiens_hsa006701.89398284
20Huntingtons disease_Homo sapiens_hsa050161.68694281
21RNA degradation_Homo sapiens_hsa030181.68047040
22Cell cycle_Homo sapiens_hsa041101.62681553
23Folate biosynthesis_Homo sapiens_hsa007901.57380921
24* Purine metabolism_Homo sapiens_hsa002301.57022931
25Sulfur relay system_Homo sapiens_hsa041221.53316219
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50734964
27Fatty acid elongation_Homo sapiens_hsa000621.47962319
28Pyruvate metabolism_Homo sapiens_hsa006201.35189866
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34747766
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29184675
31Sulfur metabolism_Homo sapiens_hsa009201.25538784
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23296098
33p53 signaling pathway_Homo sapiens_hsa041151.17175095
34Alzheimers disease_Homo sapiens_hsa050101.16392004
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08255876
36Non-homologous end-joining_Homo sapiens_hsa034501.03806346
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93184123
38* Epstein-Barr virus infection_Homo sapiens_hsa051690.91056015
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88083975
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86621715
41Herpes simplex infection_Homo sapiens_hsa051680.86332060
42Vitamin B6 metabolism_Homo sapiens_hsa007500.84900656
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.84794100
44mRNA surveillance pathway_Homo sapiens_hsa030150.82369325
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.81071636
46Pentose phosphate pathway_Homo sapiens_hsa000300.78707534
47Collecting duct acid secretion_Homo sapiens_hsa049660.74241191
48Glutathione metabolism_Homo sapiens_hsa004800.71899832
49Arachidonic acid metabolism_Homo sapiens_hsa005900.68745866
50Antigen processing and presentation_Homo sapiens_hsa046120.68565592
51Tyrosine metabolism_Homo sapiens_hsa003500.67066656
52Systemic lupus erythematosus_Homo sapiens_hsa053220.66159508
53Other glycan degradation_Homo sapiens_hsa005110.61240370
54* Metabolic pathways_Homo sapiens_hsa011000.61042314
55Regulation of autophagy_Homo sapiens_hsa041400.59991682
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59387400
57Vibrio cholerae infection_Homo sapiens_hsa051100.58556405
58Primary immunodeficiency_Homo sapiens_hsa053400.57657004
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57433076
60Phenylalanine metabolism_Homo sapiens_hsa003600.55936078
61Legionellosis_Homo sapiens_hsa051340.53155306
62Graft-versus-host disease_Homo sapiens_hsa053320.52481899
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52189846
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51138898
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50694691
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49865105
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.49843301
68Allograft rejection_Homo sapiens_hsa053300.49005433
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.48738736
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48102218
71Chemical carcinogenesis_Homo sapiens_hsa052040.47696163
72Tryptophan metabolism_Homo sapiens_hsa003800.47392416
73Propanoate metabolism_Homo sapiens_hsa006400.46921624
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.45637283
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45145700
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.44827505
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44603152
78Measles_Homo sapiens_hsa051620.44371810
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42696269
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40391206
81Biosynthesis of amino acids_Homo sapiens_hsa012300.40293554
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39860982
83Cardiac muscle contraction_Homo sapiens_hsa042600.39520855
84Galactose metabolism_Homo sapiens_hsa000520.38886853
85Selenocompound metabolism_Homo sapiens_hsa004500.35293270
86Hematopoietic cell lineage_Homo sapiens_hsa046400.34937453
87Asthma_Homo sapiens_hsa053100.34215223
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33293228
89Vitamin digestion and absorption_Homo sapiens_hsa049770.32705976
90Basal cell carcinoma_Homo sapiens_hsa052170.32680174
91Carbon metabolism_Homo sapiens_hsa012000.32475312
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29410120
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28742021
94N-Glycan biosynthesis_Homo sapiens_hsa005100.28487675
95Arginine and proline metabolism_Homo sapiens_hsa003300.28312387
96HTLV-I infection_Homo sapiens_hsa051660.27994561
97Influenza A_Homo sapiens_hsa051640.27341690
98Leishmaniasis_Homo sapiens_hsa051400.26903387
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26222961
100Fructose and mannose metabolism_Homo sapiens_hsa000510.25854899
101Rheumatoid arthritis_Homo sapiens_hsa053230.25505169
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25306166
103Apoptosis_Homo sapiens_hsa042100.25303065
104beta-Alanine metabolism_Homo sapiens_hsa004100.25173574
105Thyroid cancer_Homo sapiens_hsa052160.24042311
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23975390
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23867287
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22512106
109Fatty acid degradation_Homo sapiens_hsa000710.21850889
110Mineral absorption_Homo sapiens_hsa049780.21767037
111Viral carcinogenesis_Homo sapiens_hsa052030.20064088
112Steroid biosynthesis_Homo sapiens_hsa001000.19576580
113Autoimmune thyroid disease_Homo sapiens_hsa053200.19217826
114Lysosome_Homo sapiens_hsa041420.18636809
115Sphingolipid metabolism_Homo sapiens_hsa006000.18169004
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.17839128
117Pertussis_Homo sapiens_hsa051330.17339042
118Malaria_Homo sapiens_hsa051440.17103386
119Fatty acid metabolism_Homo sapiens_hsa012120.15632755
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15005089
121Linoleic acid metabolism_Homo sapiens_hsa005910.14886875
122Type I diabetes mellitus_Homo sapiens_hsa049400.13984776
123Peroxisome_Homo sapiens_hsa041460.13889932
124Butanoate metabolism_Homo sapiens_hsa006500.13657464
125Retinol metabolism_Homo sapiens_hsa008300.13515077
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.12802043
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12730374
128Shigellosis_Homo sapiens_hsa051310.12722466
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12698643
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12347252
131Hedgehog signaling pathway_Homo sapiens_hsa043400.10138436
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.09399262
133Caffeine metabolism_Homo sapiens_hsa002320.09061054
134Fat digestion and absorption_Homo sapiens_hsa049750.08959620
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07863099

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