POLR2F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.29474146
2viral transcription (GO:0019083)6.10812778
3ribosomal small subunit assembly (GO:0000028)5.95441085
4translational termination (GO:0006415)5.93009496
5maturation of SSU-rRNA (GO:0030490)5.81713306
6DNA deamination (GO:0045006)5.73756190
7electron transport chain (GO:0022900)5.48008384
8protein complex biogenesis (GO:0070271)5.24330419
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.19043786
10translational elongation (GO:0006414)5.16886557
11cotranslational protein targeting to membrane (GO:0006613)5.12113600
12protein targeting to ER (GO:0045047)5.08331343
13mitochondrial respiratory chain complex assembly (GO:0033108)5.00934209
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.99722282
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.99722282
16ribosomal large subunit biogenesis (GO:0042273)4.94754719
17translational initiation (GO:0006413)4.87679736
18proteasome assembly (GO:0043248)4.86594581
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83656286
20protein localization to endoplasmic reticulum (GO:0070972)4.81936779
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.68471646
22viral life cycle (GO:0019058)4.68407524
23cellular protein complex disassembly (GO:0043624)4.67629398
24ribonucleoprotein complex biogenesis (GO:0022613)4.57682574
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56659637
26ATP synthesis coupled proton transport (GO:0015986)4.26883483
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26883483
28formation of translation preinitiation complex (GO:0001731)4.26147253
29translation (GO:0006412)4.25789595
30* transcription elongation from RNA polymerase III promoter (GO:0006385)4.18361267
31* termination of RNA polymerase III transcription (GO:0006386)4.18361267
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.10970814
33rRNA processing (GO:0006364)4.09348213
34protein complex disassembly (GO:0043241)4.08695424
35spliceosomal snRNP assembly (GO:0000387)4.06567390
36respiratory chain complex IV assembly (GO:0008535)3.98597753
37telomere maintenance via semi-conservative replication (GO:0032201)3.94341300
38rRNA metabolic process (GO:0016072)3.93017753
39DNA replication checkpoint (GO:0000076)3.87731568
40macromolecular complex disassembly (GO:0032984)3.87480702
41cellular component biogenesis (GO:0044085)3.86162563
42DNA strand elongation involved in DNA replication (GO:0006271)3.85925835
43ribosome biogenesis (GO:0042254)3.85458550
44rRNA modification (GO:0000154)3.84839856
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83379071
46ATP biosynthetic process (GO:0006754)3.76349772
47protein localization to mitochondrion (GO:0070585)3.75401188
48cytochrome complex assembly (GO:0017004)3.75190917
49DNA replication initiation (GO:0006270)3.71539319
50pseudouridine synthesis (GO:0001522)3.70986308
51inner mitochondrial membrane organization (GO:0007007)3.69298804
52* 7-methylguanosine mRNA capping (GO:0006370)3.69293555
53DNA strand elongation (GO:0022616)3.67358921
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.66243109
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65476348
56mitotic metaphase plate congression (GO:0007080)3.63869096
57spliceosomal complex assembly (GO:0000245)3.63381121
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63357930
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.62890088
60* 7-methylguanosine RNA capping (GO:0009452)3.61178670
61* RNA capping (GO:0036260)3.61178670
62establishment of integrated proviral latency (GO:0075713)3.61102283
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59385816
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59275897
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57732786
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57718097
67negative regulation of ligase activity (GO:0051352)3.57290119
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57290119
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56221855
70hydrogen ion transmembrane transport (GO:1902600)3.52791652
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52246216
72oxidative phosphorylation (GO:0006119)3.51082583
73protein neddylation (GO:0045116)3.50086493
74mRNA catabolic process (GO:0006402)3.45335975
75* transcription-coupled nucleotide-excision repair (GO:0006283)3.42796934
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40240495
77telomere maintenance via recombination (GO:0000722)3.40099717
78DNA damage response, detection of DNA damage (GO:0042769)3.36913482
79nucleobase biosynthetic process (GO:0046112)3.35781220
80ribonucleoside triphosphate biosynthetic process (GO:0009201)3.35373076
81intracellular protein transmembrane import (GO:0044743)3.33955038
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33282413
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33282413
84CENP-A containing nucleosome assembly (GO:0034080)3.33024337
85ribosome assembly (GO:0042255)3.32640807
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32345586
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32345586
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31965984
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31965984
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31965984
91transcription elongation from RNA polymerase I promoter (GO:0006362)3.30302242
92kinetochore assembly (GO:0051382)3.29797356
93termination of RNA polymerase I transcription (GO:0006363)3.29272250
94protein targeting to mitochondrion (GO:0006626)3.29220647
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.29007397
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29007397
97protein targeting to membrane (GO:0006612)3.28948889
98RNA catabolic process (GO:0006401)3.28269351
99establishment of protein localization to mitochondrion (GO:0072655)3.27897445
100chromatin remodeling at centromere (GO:0031055)3.27772195
101regulation of cellular amino acid metabolic process (GO:0006521)3.26319126
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26066610
103mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26051281
104chaperone-mediated protein transport (GO:0072321)3.25766112
105mitochondrial transport (GO:0006839)3.24252975
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.24076393
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22314143
108regulation of mitochondrial translation (GO:0070129)3.21622799
109cullin deneddylation (GO:0010388)3.20812271
110* transcription from RNA polymerase I promoter (GO:0006360)3.20780896
111purine nucleobase biosynthetic process (GO:0009113)3.19681851
112telomere maintenance via telomere lengthening (GO:0010833)3.17700423
113maturation of 5.8S rRNA (GO:0000460)3.17041636
114GTP biosynthetic process (GO:0006183)3.14500917
115protein deneddylation (GO:0000338)3.12618624
116protein-cofactor linkage (GO:0018065)3.12450809
117proton transport (GO:0015992)3.10678300
118UTP biosynthetic process (GO:0006228)3.10548975
119regulation of double-strand break repair via homologous recombination (GO:0010569)3.09955418
120positive regulation of ligase activity (GO:0051351)3.08969916
121respiratory electron transport chain (GO:0022904)3.07758589
122nucleotide-excision repair, DNA gap filling (GO:0006297)3.07026579
123nucleoside triphosphate biosynthetic process (GO:0009142)3.06468984
124NADH dehydrogenase complex assembly (GO:0010257)3.05733016
125hydrogen transport (GO:0006818)3.04380239
126base-excision repair, AP site formation (GO:0006285)3.03097140
127peptidyl-histidine modification (GO:0018202)2.99361955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22924565
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.63295223
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15494514
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83725868
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.81818521
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.81069246
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68208054
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.61801069
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30234825
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28376325
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28199298
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.24352492
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09227293
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04893833
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01410020
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00848389
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94342751
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71705268
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65398716
20XRN2_22483619_ChIP-Seq_HELA_Human2.60663417
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60293037
22VDR_23849224_ChIP-Seq_CD4+_Human2.51137491
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47633519
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.37263471
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31010312
26DCP1A_22483619_ChIP-Seq_HELA_Human2.29695287
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29378200
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25114827
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22116890
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.13465633
31TTF2_22483619_ChIP-Seq_HELA_Human2.10276406
32FOXP3_21729870_ChIP-Seq_TREG_Human2.04992386
33GABP_19822575_ChIP-Seq_HepG2_Human2.03115995
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98029051
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94777461
36* SRF_21415370_ChIP-Seq_HL-1_Mouse1.91097780
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86625481
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84498270
39ELK1_19687146_ChIP-ChIP_HELA_Human1.78338620
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77964104
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69399509
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62986165
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61639999
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58997677
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56597512
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52111722
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48424351
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44423077
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43392947
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42488092
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.42441081
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42423722
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39315193
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36149430
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33792395
56ZNF274_21170338_ChIP-Seq_K562_Hela1.33696808
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31997906
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31779910
59AR_21909140_ChIP-Seq_LNCAP_Human1.30726150
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30182332
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.25629128
62KDM5A_27292631_Chip-Seq_BREAST_Human1.25346024
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24534568
64* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23967040
65CIITA_25753668_ChIP-Seq_RAJI_Human1.23376536
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22945441
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20789732
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19402224
69MYC_18940864_ChIP-ChIP_HL60_Human1.18100266
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18081144
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17626539
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17595922
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10295292
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07872832
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07582609
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06807905
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06717100
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06497596
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06497596
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06497596
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.04628391
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04418327
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03762785
84* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03552698
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.02481623
86EWS_26573619_Chip-Seq_HEK293_Human1.02198826
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01693214
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01408466
89VDR_22108803_ChIP-Seq_LS180_Human0.99879921
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99601325
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99076338
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98310800
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98006351
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96201130
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94206450
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.93797632
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92365265
98* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92117891
99TP53_22573176_ChIP-Seq_HFKS_Human0.90148791
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89812981
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88549146
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87870316
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86739608
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.86462446
105TFEB_21752829_ChIP-Seq_HELA_Human0.84431220
106* TP63_19390658_ChIP-ChIP_HaCaT_Human0.80879775
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79976382
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79342534
109FOXP1_21924763_ChIP-Seq_HESCs_Human0.78888658
110FUS_26573619_Chip-Seq_HEK293_Human0.78471826
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.78380479
112POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76758124
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76746263
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75861301
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75587392
116NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75353920
117IRF1_19129219_ChIP-ChIP_H3396_Human0.74730287
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73616255
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72563122
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69554393
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67699502
122HTT_18923047_ChIP-ChIP_STHdh_Human0.66875026
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.64741453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61864690
2MP0004957_abnormal_blastocyst_morpholog4.57727327
3MP0003111_abnormal_nucleus_morphology3.79491656
4MP0010094_abnormal_chromosome_stability3.71715855
5MP0003077_abnormal_cell_cycle3.56442465
6MP0009379_abnormal_foot_pigmentation3.47055843
7MP0008932_abnormal_embryonic_tissue3.14478645
8MP0008057_abnormal_DNA_replication3.12072615
9MP0008058_abnormal_DNA_repair3.05558616
10MP0003136_yellow_coat_color2.84644233
11MP0003718_maternal_effect2.80641827
12MP0003786_premature_aging2.52605147
13MP0008007_abnormal_cellular_replicative2.33226561
14MP0003123_paternal_imprinting2.18710015
15MP0006292_abnormal_olfactory_placode2.12654478
16MP0002736_abnormal_nociception_after1.89626997
17MP0006072_abnormal_retinal_apoptosis1.82547442
18MP0001730_embryonic_growth_arrest1.81674288
19MP0003186_abnormal_redox_activity1.80840421
20MP0003806_abnormal_nucleotide_metabolis1.74647460
21MP0005646_abnormal_pituitary_gland1.73767173
22MP0004142_abnormal_muscle_tone1.71879534
23MP0000350_abnormal_cell_proliferation1.71003882
24MP0001529_abnormal_vocalization1.68540814
25MP0003011_delayed_dark_adaptation1.67735113
26MP0008877_abnormal_DNA_methylation1.66161882
27MP0006036_abnormal_mitochondrial_physio1.61543528
28MP0010030_abnormal_orbit_morphology1.61115699
29MP0003941_abnormal_skin_development1.59984229
30MP0001968_abnormal_touch/_nociception1.56420580
31MP0002132_abnormal_respiratory_system1.54394779
32MP0002653_abnormal_ependyma_morphology1.53614502
33MP0006035_abnormal_mitochondrial_morpho1.52889760
34MP0000490_abnormal_crypts_of1.52299531
35MP0009333_abnormal_splenocyte_physiolog1.49063814
36MP0002102_abnormal_ear_morphology1.48358196
37MP0004133_heterotaxia1.46442424
38MP0003315_abnormal_perineum_morphology1.44568316
39MP0002234_abnormal_pharynx_morphology1.43422607
40MP0005084_abnormal_gallbladder_morpholo1.39891518
41MP0000631_abnormal_neuroendocrine_gland1.39773090
42MP0002210_abnormal_sex_determination1.35673127
43MP0002938_white_spotting1.34610328
44MP0001697_abnormal_embryo_size1.32992935
45MP0005075_abnormal_melanosome_morpholog1.30275672
46MP0002837_dystrophic_cardiac_calcinosis1.30020413
47MP0000313_abnormal_cell_death1.30018590
48MP0003567_abnormal_fetal_cardiomyocyte1.26042424
49MP0002085_abnormal_embryonic_tissue1.25087102
50MP0003880_abnormal_central_pattern1.24148169
51MP0009046_muscle_twitch1.24143021
52MP0001672_abnormal_embryogenesis/_devel1.23794965
53MP0005380_embryogenesis_phenotype1.23794965
54MP0005551_abnormal_eye_electrophysiolog1.23429317
55MP0002080_prenatal_lethality1.23415245
56MP0009697_abnormal_copulation1.22843344
57MP0000750_abnormal_muscle_regeneration1.21922531
58MP0002163_abnormal_gland_morphology1.20313875
59MP0008995_early_reproductive_senescence1.17228399
60MP0004381_abnormal_hair_follicle1.16597306
61MP0001984_abnormal_olfaction1.14785148
62MP0001145_abnormal_male_reproductive1.13584905
63MP0002396_abnormal_hematopoietic_system1.12350641
64MP0001727_abnormal_embryo_implantation1.12136025
65MP0001293_anophthalmia1.11941483
66MP0005499_abnormal_olfactory_system1.11692106
67MP0005394_taste/olfaction_phenotype1.11692106
68MP0005253_abnormal_eye_physiology1.11028657
69MP0005451_abnormal_body_composition1.07835958
70MP0001764_abnormal_homeostasis1.07112125
71MP0002272_abnormal_nervous_system1.06711481
72MP0009745_abnormal_behavioral_response1.04608608
73MP0002019_abnormal_tumor_incidence1.04027357
74MP0000372_irregular_coat_pigmentation1.03663582
75MP0003119_abnormal_digestive_system1.01956186
76MP0000358_abnormal_cell_content/1.01528799
77MP0008875_abnormal_xenobiotic_pharmacok1.00734869
78MP0006276_abnormal_autonomic_nervous1.00071899
79MP0000049_abnormal_middle_ear0.98994736
80MP0002084_abnormal_developmental_patter0.98371984
81MP0003938_abnormal_ear_development0.98157958
82MP0001929_abnormal_gametogenesis0.97330077
83MP0003984_embryonic_growth_retardation0.97185089
84MP0000653_abnormal_sex_gland0.96746889
85MP0005379_endocrine/exocrine_gland_phen0.95380482
86MP0008260_abnormal_autophagy0.95168424
87MP0005408_hypopigmentation0.93691799
88MP0002088_abnormal_embryonic_growth/wei0.93286664
89MP0002277_abnormal_respiratory_mucosa0.93032505
90MP0003195_calcinosis0.92032828
91MP0008872_abnormal_physiological_respon0.91231544
92MP0003890_abnormal_embryonic-extraembry0.90289543
93MP0002160_abnormal_reproductive_system0.90246709
94MP0000566_synostosis0.89361008
95MP0004147_increased_porphyrin_level0.88458183
96MP0001905_abnormal_dopamine_level0.87916396
97MP0003646_muscle_fatigue0.87582103
98MP0002249_abnormal_larynx_morphology0.86373912
99MP0005423_abnormal_somatic_nervous0.85922470
100MP0005645_abnormal_hypothalamus_physiol0.83919985
101MP0003787_abnormal_imprinting0.83602520
102MP0008789_abnormal_olfactory_epithelium0.81903458
103MP0001346_abnormal_lacrimal_gland0.80311843
104MP0001485_abnormal_pinna_reflex0.80247016
105MP0005397_hematopoietic_system_phenotyp0.79381734
106MP0001545_abnormal_hematopoietic_system0.79381734
107MP0001986_abnormal_taste_sensitivity0.77155963
108MP0003698_abnormal_male_reproductive0.76487210
109MP0003937_abnormal_limbs/digits/tail_de0.75551241
110MP0003121_genomic_imprinting0.75472947
111MP0002638_abnormal_pupillary_reflex0.75463277
112MP0002064_seizures0.75444844
113MP0002734_abnormal_mechanical_nocicepti0.75014006
114MP0001486_abnormal_startle_reflex0.74450237
115MP0004742_abnormal_vestibular_system0.74402980
116MP0000762_abnormal_tongue_morphology0.73998953
117MP0005174_abnormal_tail_pigmentation0.73462897
118MP0002752_abnormal_somatic_nervous0.73145867
119MP0000026_abnormal_inner_ear0.73028795
120MP0005410_abnormal_fertilization0.72238729
121MP0001119_abnormal_female_reproductive0.71976195
122MP0003122_maternal_imprinting0.71941031
123MP0005389_reproductive_system_phenotype0.71762314
124MP0005195_abnormal_posterior_eye0.71610125
125MP0001919_abnormal_reproductive_system0.71301632
126MP0001853_heart_inflammation0.71041758
127MP0002751_abnormal_autonomic_nervous0.70993998
128MP0002086_abnormal_extraembryonic_tissu0.70932198
129MP0002111_abnormal_tail_morphology0.67157497
130MP0002095_abnormal_skin_pigmentation0.66846434
131MP0001188_hyperpigmentation0.66449748
132MP0003221_abnormal_cardiomyocyte_apopto0.65770446
133MP0001286_abnormal_eye_development0.62908308
134MP0005266_abnormal_metabolism0.60196322
135MP0001542_abnormal_bone_strength0.59889084
136MP0004197_abnormal_fetal_growth/weight/0.59083277
137MP0005395_other_phenotype0.57524787
138MP0005501_abnormal_skin_physiology0.56756070
139MP0003936_abnormal_reproductive_system0.56218141
140MP0005377_hearing/vestibular/ear_phenot0.54013265
141MP0003878_abnormal_ear_physiology0.54013265
142MP0002722_abnormal_immune_system0.53726443

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.17862226
2Abnormal number of erythroid precursors (HP:0012131)5.72012391
3Reticulocytopenia (HP:0001896)5.22542483
4Acute necrotizing encephalopathy (HP:0006965)4.48135177
5Macrocytic anemia (HP:0001972)4.21377098
6Mitochondrial inheritance (HP:0001427)4.04009951
7Birth length less than 3rd percentile (HP:0003561)4.00991493
8Abnormal mitochondria in muscle tissue (HP:0008316)3.96208561
9Breast hypoplasia (HP:0003187)3.91293857
10Pallor (HP:0000980)3.68838703
11Hepatocellular necrosis (HP:0001404)3.64878728
12Cerebral hypomyelination (HP:0006808)3.62979466
133-Methylglutaconic aciduria (HP:0003535)3.61307937
14Increased hepatocellular lipid droplets (HP:0006565)3.58096277
15Increased CSF lactate (HP:0002490)3.57965063
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.55974599
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.55974599
18Acute encephalopathy (HP:0006846)3.46825671
19Progressive macrocephaly (HP:0004481)3.44122783
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.38817313
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.37302918
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.32772112
23Rough bone trabeculation (HP:0100670)3.29496171
24Oral leukoplakia (HP:0002745)3.24364799
25Hepatic necrosis (HP:0002605)3.11622462
26Lipid accumulation in hepatocytes (HP:0006561)3.09811127
27Increased serum lactate (HP:0002151)2.98244866
28Carpal bone hypoplasia (HP:0001498)2.87402582
29Multiple enchondromatosis (HP:0005701)2.84726147
30Renal Fanconi syndrome (HP:0001994)2.84098977
31Aplastic anemia (HP:0001915)2.83244569
32Exertional dyspnea (HP:0002875)2.81733676
33Abnormality of glycolysis (HP:0004366)2.81349583
34Increased serum pyruvate (HP:0003542)2.81349583
35Patellar aplasia (HP:0006443)2.80381644
36Aplasia/Hypoplasia of the patella (HP:0006498)2.69151383
37Exercise intolerance (HP:0003546)2.66956304
38Type I transferrin isoform profile (HP:0003642)2.61291613
39Trismus (HP:0000211)2.59872059
40Absent thumb (HP:0009777)2.54075813
41Absent radius (HP:0003974)2.53734196
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53170826
43Respiratory failure (HP:0002878)2.52622695
44Premature graying of hair (HP:0002216)2.51618677
45Secondary amenorrhea (HP:0000869)2.51126122
46Increased intramyocellular lipid droplets (HP:0012240)2.50863744
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49636007
48Abnormal trabecular bone morphology (HP:0100671)2.48412057
49Lethargy (HP:0001254)2.46757901
50Pancreatic cysts (HP:0001737)2.45836460
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45755152
52Abnormality of renal resorption (HP:0011038)2.44943084
53Microvesicular hepatic steatosis (HP:0001414)2.44499322
54Aplasia involving forearm bones (HP:0009822)2.44403324
55Absent forearm bone (HP:0003953)2.44403324
56Microretrognathia (HP:0000308)2.44174750
57Sparse eyelashes (HP:0000653)2.43499722
58Respiratory difficulties (HP:0002880)2.40886650
59Chromsome breakage (HP:0040012)2.39891653
60Pancreatic fibrosis (HP:0100732)2.37602058
61Lactic acidosis (HP:0003128)2.35863879
62Meckel diverticulum (HP:0002245)2.34829821
63Methylmalonic aciduria (HP:0012120)2.33898999
64Abnormality of the preputium (HP:0100587)2.33007694
65Premature ovarian failure (HP:0008209)2.32921358
66Selective tooth agenesis (HP:0001592)2.31332355
67Abnormality of midbrain morphology (HP:0002418)2.31195841
68Molar tooth sign on MRI (HP:0002419)2.31195841
69Colon cancer (HP:0003003)2.30306988
70Abnormality of the anterior horn cell (HP:0006802)2.28307672
71Degeneration of anterior horn cells (HP:0002398)2.28307672
72Abnormality of the ileum (HP:0001549)2.28132089
73Aplasia/hypoplasia of the uterus (HP:0008684)2.27654347
74Septo-optic dysplasia (HP:0100842)2.25879732
7511 pairs of ribs (HP:0000878)2.23674834
76Methylmalonic acidemia (HP:0002912)2.22802827
77Cerebral edema (HP:0002181)2.22723718
78Sclerocornea (HP:0000647)2.21939361
79Abnormality of urine glucose concentration (HP:0011016)2.20736124
80Glycosuria (HP:0003076)2.20736124
81Leukodystrophy (HP:0002415)2.19364755
82Triphalangeal thumb (HP:0001199)2.17804265
83Hyperglycinemia (HP:0002154)2.17554635
84X-linked dominant inheritance (HP:0001423)2.13435836
85Supernumerary spleens (HP:0009799)2.11876935
86Horseshoe kidney (HP:0000085)2.11449509
87Hypoplasia of the radius (HP:0002984)2.10748633
88True hermaphroditism (HP:0010459)2.10629565
89Cleft eyelid (HP:0000625)2.08106021
90CNS demyelination (HP:0007305)2.06445555
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04880537
92Abnormal protein N-linked glycosylation (HP:0012347)2.04880537
93Abnormal protein glycosylation (HP:0012346)2.04880537
94Abnormal glycosylation (HP:0012345)2.04880537
95Glossoptosis (HP:0000162)2.04355174
96CNS hypomyelination (HP:0003429)2.03403652
97Increased muscle lipid content (HP:0009058)1.98887901
98Generalized aminoaciduria (HP:0002909)1.98676333
99Hyperphosphaturia (HP:0003109)1.98675117
100Bone marrow hypocellularity (HP:0005528)1.98191273
101Abnormal lung lobation (HP:0002101)1.98020593
102Congenital, generalized hypertrichosis (HP:0004540)1.97287921
103Concave nail (HP:0001598)1.96336858
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95718321
105Abnormality of alanine metabolism (HP:0010916)1.95718321
106Hyperalaninemia (HP:0003348)1.95718321
107Abnormality of the labia minora (HP:0012880)1.95427253
108Congenital ichthyosiform erythroderma (HP:0007431)1.94184082
109Emotional lability (HP:0000712)1.94140779
110Progressive muscle weakness (HP:0003323)1.93682687
111Hypoplasia of the pons (HP:0012110)1.90119436
112Pendular nystagmus (HP:0012043)1.88145095
113Abnormality of placental membranes (HP:0011409)1.86881582
114Amniotic constriction ring (HP:0009775)1.86881582
115Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86662520
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.86312635
117Poor head control (HP:0002421)1.85491696
118Abnormal hemoglobin (HP:0011902)1.85140944
119Myokymia (HP:0002411)1.84620765
120Duplicated collecting system (HP:0000081)1.84485146
121Pancytopenia (HP:0001876)1.84373794
122Optic disc pallor (HP:0000543)1.83746361
123Cellular immunodeficiency (HP:0005374)1.83212296
124Abnormality of the umbilical cord (HP:0010881)1.83186560
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.83121759
126Muscle fiber atrophy (HP:0100295)1.80991992
127Abnormality of the pons (HP:0007361)1.79610264
128Tracheoesophageal fistula (HP:0002575)1.77710364
129Blindness (HP:0000618)1.76950366
130Abnormality of serum amino acid levels (HP:0003112)1.74945147
131Atresia of the external auditory canal (HP:0000413)1.74876053
132Nephronophthisis (HP:0000090)1.72629029
133Absent septum pellucidum (HP:0001331)1.72546657
134Reduced antithrombin III activity (HP:0001976)1.72305671
135Testicular atrophy (HP:0000029)1.71100091
136Medial flaring of the eyebrow (HP:0010747)1.66090807
137Abnormal number of incisors (HP:0011064)1.64055387
138Rib fusion (HP:0000902)1.61273501
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60684215
140Dicarboxylic aciduria (HP:0003215)1.60684215
141Megaloblastic anemia (HP:0001889)1.58196179
142Delayed CNS myelination (HP:0002188)1.56972728
143Progressive microcephaly (HP:0000253)1.56413707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.33156997
2VRK25.27467595
3NME24.15778323
4WEE13.97476370
5STK163.48352729
6EIF2AK13.19484370
7TLK12.88690647
8SRPK12.66382090
9VRK12.62220148
10PLK42.45520767
11CDC72.19551820
12PIM22.09326450
13NME12.06800977
14NUAK11.97081277
15TESK21.92202177
16TTK1.79601655
17PLK11.76693429
18DYRK31.76036581
19EIF2AK31.73729113
20WNK31.73559130
21BRSK21.67042123
22PBK1.65467857
23BRAF1.54623687
24MST41.52030263
25CDK71.51915072
26NEK21.51842427
27ARAF1.50415728
28MKNK11.49807618
29DYRK21.47406482
30AURKA1.44388335
31AURKB1.41448961
32TSSK61.38997371
33BMPR1B1.37449274
34TNIK1.33060326
35TAF11.31624871
36RPS6KB21.31553126
37MAP4K21.30173467
38EPHA21.28754802
39INSRR1.27208476
40PDK21.21584904
41MAP3K111.13083533
42MKNK21.12766474
43MAP2K71.11852941
44BRSK11.07787690
45LIMK11.07161302
46CHEK21.06887090
47ACVR1B1.06442948
48ZAK1.02694069
49CSNK1G21.00661358
50PLK30.99076018
51MUSK0.95658740
52MAP3K80.94856642
53ATR0.93853404
54NEK10.93764498
55MAP3K120.92373049
56CDK80.91450788
57CDK190.91367458
58ABL20.90660436
59TRIM280.89139716
60RPS6KA40.88144914
61PAK10.86840473
62BCKDK0.85704730
63MAPKAPK30.83941718
64ILK0.83749228
65RPS6KA50.81641905
66STK38L0.81590421
67CSNK1A1L0.81528464
68PAK40.81201504
69IRAK30.79359922
70* CSNK2A10.79006800
71PRKCI0.76732240
72CASK0.76389523
73MAP3K40.75836108
74* CSNK2A20.75064603
75IRAK40.72298535
76KDR0.71395175
77CHEK10.70833612
78WNK40.70514100
79PRKCG0.69035972
80EIF2AK20.68898090
81LRRK20.68519417
82STK40.67303411
83PINK10.66762231
84PNCK0.65465167
85TESK10.64094972
86CSNK1G30.63494248
87LATS20.63412523
88PIM10.62439708
89CCNB10.61451894
90ADRBK20.60936530
91PASK0.59109866
92DAPK10.55878681
93PLK20.53718042
94PHKG10.52462814
95PHKG20.52462814
96STK240.49072631
97CDK20.48330733
98OXSR10.47757380
99MAPK130.46539708
100DAPK30.46118107
101IRAK20.45375175
102ATM0.45323578
103CDK40.44493391
104CSNK1A10.44274236
105MAP2K20.42671724
106STK100.40825612
107EPHA40.40628103
108MINK10.39804209
109ADRBK10.39774941
110CSNK1G10.38072839
111AKT20.37176965
112PKN10.34929668
113CDK30.34870444
114CDK10.34002307
115YES10.33285674
116CSNK1E0.33273019
117GRK70.33090279
118MYLK0.32913884
119AKT30.32543040
120UHMK10.31212413
121PRKACA0.30943775
122BCR0.29378435
123CLK10.28504956
124GRK50.26848713
125CDK11A0.23671549
126IKBKB0.23156216
127MAPKAPK50.22639912
128RAF10.21878287
129GRK10.20575959
130MOS0.18909296
131TGFBR10.18872400
132MAPKAPK20.18844485

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.57184714
2Proteasome_Homo sapiens_hsa030504.22819672
3* RNA polymerase_Homo sapiens_hsa030204.14430401
4DNA replication_Homo sapiens_hsa030303.79854207
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33760832
6Mismatch repair_Homo sapiens_hsa034303.31622625
7Spliceosome_Homo sapiens_hsa030403.06606577
8Oxidative phosphorylation_Homo sapiens_hsa001903.06101776
9Parkinsons disease_Homo sapiens_hsa050122.75458202
10* Pyrimidine metabolism_Homo sapiens_hsa002402.69532166
11Homologous recombination_Homo sapiens_hsa034402.66452444
12RNA transport_Homo sapiens_hsa030132.50916998
13Nucleotide excision repair_Homo sapiens_hsa034202.48082723
14Base excision repair_Homo sapiens_hsa034102.39269999
15Huntingtons disease_Homo sapiens_hsa050162.27169888
16Basal transcription factors_Homo sapiens_hsa030222.05952232
17Protein export_Homo sapiens_hsa030601.94866607
18Fanconi anemia pathway_Homo sapiens_hsa034601.80864334
19Cell cycle_Homo sapiens_hsa041101.80254920
20Alzheimers disease_Homo sapiens_hsa050101.79582340
21RNA degradation_Homo sapiens_hsa030181.73862357
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64626326
23One carbon pool by folate_Homo sapiens_hsa006701.56927901
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48876883
25Vitamin B6 metabolism_Homo sapiens_hsa007501.46578655
26* Purine metabolism_Homo sapiens_hsa002301.45515079
27* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36099543
28Folate biosynthesis_Homo sapiens_hsa007901.29869164
29Non-homologous end-joining_Homo sapiens_hsa034501.25463667
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20995382
31Sulfur relay system_Homo sapiens_hsa041221.14396462
32p53 signaling pathway_Homo sapiens_hsa041151.11231786
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10035738
34mRNA surveillance pathway_Homo sapiens_hsa030151.08212636
35Pyruvate metabolism_Homo sapiens_hsa006201.04089680
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01499391
37Cardiac muscle contraction_Homo sapiens_hsa042600.96375222
38Glutathione metabolism_Homo sapiens_hsa004800.91015280
39* Epstein-Barr virus infection_Homo sapiens_hsa051690.90313886
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88566881
41Propanoate metabolism_Homo sapiens_hsa006400.88472052
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81955472
43Sulfur metabolism_Homo sapiens_hsa009200.78916057
44Arachidonic acid metabolism_Homo sapiens_hsa005900.78747308
45Peroxisome_Homo sapiens_hsa041460.76816128
46Systemic lupus erythematosus_Homo sapiens_hsa053220.76700038
47Butanoate metabolism_Homo sapiens_hsa006500.72384071
48Linoleic acid metabolism_Homo sapiens_hsa005910.69276513
49Pentose phosphate pathway_Homo sapiens_hsa000300.67148985
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.67041184
51Phototransduction_Homo sapiens_hsa047440.64955166
52Nitrogen metabolism_Homo sapiens_hsa009100.62548977
53* Metabolic pathways_Homo sapiens_hsa011000.62107970
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59744526
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56778367
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54664236
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54435906
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.52388067
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.51841503
60Nicotine addiction_Homo sapiens_hsa050330.51011859
61Tryptophan metabolism_Homo sapiens_hsa003800.50358658
62Chemical carcinogenesis_Homo sapiens_hsa052040.49749326
63beta-Alanine metabolism_Homo sapiens_hsa004100.49440638
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47417937
65Arginine and proline metabolism_Homo sapiens_hsa003300.47090576
66Biosynthesis of amino acids_Homo sapiens_hsa012300.46582729
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46414860
68Oocyte meiosis_Homo sapiens_hsa041140.46388877
69Regulation of autophagy_Homo sapiens_hsa041400.45396738
70Vitamin digestion and absorption_Homo sapiens_hsa049770.44873032
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.44608637
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42946780
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41058410
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.40536253
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40174235
76Herpes simplex infection_Homo sapiens_hsa051680.38798869
77Ether lipid metabolism_Homo sapiens_hsa005650.36884084
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36247257
79Viral carcinogenesis_Homo sapiens_hsa052030.34798254
80Tyrosine metabolism_Homo sapiens_hsa003500.33258433
81Fructose and mannose metabolism_Homo sapiens_hsa000510.31488160
82Caffeine metabolism_Homo sapiens_hsa002320.31090246
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29510541
84Retinol metabolism_Homo sapiens_hsa008300.27818660
85Thyroid cancer_Homo sapiens_hsa052160.27462297
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27128660
87Fatty acid elongation_Homo sapiens_hsa000620.26782593
88Fatty acid degradation_Homo sapiens_hsa000710.26466383
89Fat digestion and absorption_Homo sapiens_hsa049750.26290333
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25795537
91Steroid biosynthesis_Homo sapiens_hsa001000.25487485
92Carbon metabolism_Homo sapiens_hsa012000.25143971
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24665220
94Antigen processing and presentation_Homo sapiens_hsa046120.24281126
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23703224
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23182747
97Alcoholism_Homo sapiens_hsa050340.23118453
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22698120
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22652584
100Selenocompound metabolism_Homo sapiens_hsa004500.22611102
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22404495
102Basal cell carcinoma_Homo sapiens_hsa052170.21533310
103HTLV-I infection_Homo sapiens_hsa051660.21237072
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20888584
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20259122
106Graft-versus-host disease_Homo sapiens_hsa053320.19970831
107Fatty acid metabolism_Homo sapiens_hsa012120.19880102
108Sphingolipid metabolism_Homo sapiens_hsa006000.19739164
109Hedgehog signaling pathway_Homo sapiens_hsa043400.18090720
110Olfactory transduction_Homo sapiens_hsa047400.18051695
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17653121
112N-Glycan biosynthesis_Homo sapiens_hsa005100.17511564
113Galactose metabolism_Homo sapiens_hsa000520.14837234
114TGF-beta signaling pathway_Homo sapiens_hsa043500.13746841
115Legionellosis_Homo sapiens_hsa051340.12600777
116Other glycan degradation_Homo sapiens_hsa005110.12388097
117Allograft rejection_Homo sapiens_hsa053300.11980570
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11710043
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10983368
120Asthma_Homo sapiens_hsa053100.10941026
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10242600
122Apoptosis_Homo sapiens_hsa042100.09993540
123Primary immunodeficiency_Homo sapiens_hsa053400.08354934
124Hippo signaling pathway_Homo sapiens_hsa043900.08239129
125Notch signaling pathway_Homo sapiens_hsa043300.06166884
126Shigellosis_Homo sapiens_hsa051310.06031155
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05656482
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05505690
129Hematopoietic cell lineage_Homo sapiens_hsa046400.04650732
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.04021641
131Autoimmune thyroid disease_Homo sapiens_hsa053200.03757716
132Collecting duct acid secretion_Homo sapiens_hsa049660.03623580
133Bladder cancer_Homo sapiens_hsa052190.02857306
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.01545131
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.00237279

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