POLR2E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.64680976
2maturation of SSU-rRNA (GO:0030490)5.18016050
3ribosomal small subunit assembly (GO:0000028)5.07948633
4formation of translation preinitiation complex (GO:0001731)5.00973072
5DNA deamination (GO:0045006)4.91359266
6nucleobase biosynthetic process (GO:0046112)4.77292133
7ribosomal small subunit biogenesis (GO:0042274)4.74111018
8purine nucleobase biosynthetic process (GO:0009113)4.69666300
9viral transcription (GO:0019083)4.69376740
10translational termination (GO:0006415)4.60667451
11proteasome assembly (GO:0043248)4.59896064
12DNA strand elongation involved in DNA replication (GO:0006271)4.56585912
13ribosomal large subunit biogenesis (GO:0042273)4.36352459
14ribonucleoprotein complex biogenesis (GO:0022613)4.35989358
15DNA strand elongation (GO:0022616)4.34814647
16DNA replication initiation (GO:0006270)4.33550885
17telomere maintenance via semi-conservative replication (GO:0032201)4.31306800
18ribosome biogenesis (GO:0042254)4.30567432
19proline biosynthetic process (GO:0006561)4.27455291
20translational elongation (GO:0006414)4.24326387
21chaperone-mediated protein transport (GO:0072321)4.22185322
22translational initiation (GO:0006413)4.20416677
23DNA replication checkpoint (GO:0000076)4.09886419
24ribosome assembly (GO:0042255)4.08970008
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07085722
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00231415
27cotranslational protein targeting to membrane (GO:0006613)3.92300510
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.90756624
29spliceosomal snRNP assembly (GO:0000387)3.90307338
30mitotic nuclear envelope reassembly (GO:0007084)3.89670233
31nuclear envelope reassembly (GO:0031468)3.89670233
32protein targeting to ER (GO:0045047)3.89155434
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88733936
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88096303
35GDP-mannose metabolic process (GO:0019673)3.87971190
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87340834
37rRNA processing (GO:0006364)3.86609764
38rRNA modification (GO:0000154)3.84824755
39nucleobase-containing small molecule interconversion (GO:0015949)3.81500556
40pseudouridine synthesis (GO:0001522)3.79677798
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79548685
42establishment of viral latency (GO:0019043)3.79325706
43telomere maintenance via recombination (GO:0000722)3.75630015
44mitotic metaphase plate congression (GO:0007080)3.73111877
45negative regulation of ligase activity (GO:0051352)3.72605509
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72605509
47rRNA metabolic process (GO:0016072)3.71833347
48protein localization to endoplasmic reticulum (GO:0070972)3.68885351
49translation (GO:0006412)3.68674013
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68366412
51cellular protein complex disassembly (GO:0043624)3.66206535
52viral life cycle (GO:0019058)3.65919526
53deoxyribose phosphate biosynthetic process (GO:0046385)3.60438495
542-deoxyribonucleotide biosynthetic process (GO:0009265)3.60438495
55peptidyl-arginine omega-N-methylation (GO:0035247)3.60185757
56protein targeting to mitochondrion (GO:0006626)3.58144062
57IMP biosynthetic process (GO:0006188)3.56444902
58pentose-phosphate shunt (GO:0006098)3.55821924
59cellular component biogenesis (GO:0044085)3.53067357
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52994422
61telomere maintenance via telomere lengthening (GO:0010833)3.52715830
62* transcription elongation from RNA polymerase III promoter (GO:0006385)3.52460491
63* termination of RNA polymerase III transcription (GO:0006386)3.52460491
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.50108489
65pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.49326662
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48078568
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48078568
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48078568
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.47822982
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.47822982
71DNA unwinding involved in DNA replication (GO:0006268)3.46687503
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.45390102
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45390102
74mitotic recombination (GO:0006312)3.45089518
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44078222
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43903585
77CENP-A containing nucleosome assembly (GO:0034080)3.41126516
78guanosine-containing compound biosynthetic process (GO:1901070)3.40933056
79regulation of cellular amino acid metabolic process (GO:0006521)3.40657600
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.40215645
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.39283251
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37819356
83* transcription-coupled nucleotide-excision repair (GO:0006283)3.37583178
84pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.36785797
85chromatin remodeling at centromere (GO:0031055)3.36120946
86* 7-methylguanosine mRNA capping (GO:0006370)3.34080403
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32438732
88negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.30728658
89cullin deneddylation (GO:0010388)3.30137955
90termination of RNA polymerase I transcription (GO:0006363)3.29763481
91histone arginine methylation (GO:0034969)3.28968295
92NADPH regeneration (GO:0006740)3.28649262
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28204926
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.27764114
95* RNA capping (GO:0036260)3.26764758
96* 7-methylguanosine RNA capping (GO:0009452)3.26764758
97protein complex disassembly (GO:0043241)3.26754769
98positive regulation of ligase activity (GO:0051351)3.26467286
99establishment of protein localization to mitochondrion (GO:0072655)3.26084676
100UTP biosynthetic process (GO:0006228)3.25590267
101cell cycle G1/S phase transition (GO:0044843)3.25533867
102G1/S transition of mitotic cell cycle (GO:0000082)3.25533867
103oxidative phosphorylation (GO:0006119)3.24738431
104DNA replication-dependent nucleosome organization (GO:0034723)3.24731005
105DNA replication-dependent nucleosome assembly (GO:0006335)3.24731005
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24584025
107regulation of translational termination (GO:0006449)3.24262849
108pentose metabolic process (GO:0019321)3.22816103
109transcription elongation from RNA polymerase I promoter (GO:0006362)3.22711377
110spliceosomal complex assembly (GO:0000245)3.22042429
111energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20559497
112ATP synthesis coupled proton transport (GO:0015986)3.20559497
113UV protection (GO:0009650)3.19629612
114establishment of integrated proviral latency (GO:0075713)3.19247133
115mitotic nuclear envelope disassembly (GO:0007077)3.18895117
116rRNA transcription (GO:0009303)3.18016228
117metaphase plate congression (GO:0051310)3.17079584
118protein deneddylation (GO:0000338)3.16152560
119glucose catabolic process (GO:0006007)3.13658258
120proline metabolic process (GO:0006560)3.13626607
121L-serine metabolic process (GO:0006563)3.12867427
122macromolecular complex disassembly (GO:0032984)3.12841481
123iron-sulfur cluster assembly (GO:0016226)3.11834371
124metallo-sulfur cluster assembly (GO:0031163)3.11834371
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.11555790
126regulation of ubiquitin-protein transferase activity (GO:0051438)3.10326897
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09380660
128folic acid metabolic process (GO:0046655)3.08939953
129* transcription from RNA polymerase I promoter (GO:0006360)3.08861520
130IMP metabolic process (GO:0046040)3.08565678
131DNA replication-independent nucleosome assembly (GO:0006336)3.07778662
132DNA replication-independent nucleosome organization (GO:0034724)3.07778662
133protein localization to kinetochore (GO:0034501)3.07547952
134viral mRNA export from host cell nucleus (GO:0046784)3.07215952
135folic acid-containing compound biosynthetic process (GO:0009396)3.06995849
136regulation of mitochondrial translation (GO:0070129)3.06878197
137nuclear-transcribed mRNA catabolic process (GO:0000956)3.05791278
138GTP biosynthetic process (GO:0006183)3.03623124
139protein localization to mitochondrion (GO:0070585)3.02100631
140deoxyribonucleotide biosynthetic process (GO:0009263)3.00523762
141respiratory electron transport chain (GO:0022904)2.99793462
142NADH metabolic process (GO:0006734)2.97818614
143CTP biosynthetic process (GO:0006241)2.95224015
144CTP metabolic process (GO:0046036)2.95224015
145UTP metabolic process (GO:0046051)2.94033339
146deoxyribonucleotide catabolic process (GO:0009264)2.92688069
147electron transport chain (GO:0022900)2.89589006
148pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89041974
149transcription from mitochondrial promoter (GO:0006390)2.87812813
150deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83568720
151deoxyribose phosphate catabolic process (GO:0046386)2.80427320
152Golgi transport vesicle coating (GO:0048200)2.80409775
153COPI coating of Golgi vesicle (GO:0048205)2.80409775
154regulation of translational fidelity (GO:0006450)2.79680735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39354761
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.59750316
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93503663
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72195122
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.49537717
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44924895
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.38904445
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.37311126
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29095478
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16588875
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03136316
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02844696
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89987787
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87324098
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70008916
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.62692922
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57992863
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57576052
19XRN2_22483619_ChIP-Seq_HELA_Human2.53589236
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50080980
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40303520
22* VDR_23849224_ChIP-Seq_CD4+_Human2.37585088
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36508055
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28058727
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19474336
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.17264347
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13823879
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09777628
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06204459
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04829968
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.03084206
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02724617
33GABP_19822575_ChIP-Seq_HepG2_Human2.02646974
34* FOXP3_21729870_ChIP-Seq_TREG_Human2.02266478
35* VDR_21846776_ChIP-Seq_THP-1_Human2.00894816
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98812932
37TTF2_22483619_ChIP-Seq_HELA_Human1.96237649
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96201852
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92774076
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90102800
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86152327
42LXR_22292898_ChIP-Seq_THP-1_Human1.81796185
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.77413045
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68950019
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68691972
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67457921
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.67189659
48ZNF263_19887448_ChIP-Seq_K562_Human1.66158692
49AR_21909140_ChIP-Seq_LNCAP_Human1.65016256
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65001709
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.63208564
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61766255
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61736568
54ELK1_19687146_ChIP-ChIP_HELA_Human1.59690382
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58510041
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57563226
57CIITA_25753668_ChIP-Seq_RAJI_Human1.57520053
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53633169
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51799799
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50807384
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49513393
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49314788
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.48566113
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48278542
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46082161
66KDM5A_27292631_Chip-Seq_BREAST_Human1.41862930
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41094309
68* P68_20966046_ChIP-Seq_HELA_Human1.39902843
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.39154370
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37750429
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36852076
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30873323
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29187426
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28689758
75RACK7_27058665_Chip-Seq_MCF-7_Human1.27426523
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26807290
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26118342
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25273116
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23272561
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21259111
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21008667
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20355723
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19996540
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18758979
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18448362
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18285579
87* FOXP1_21924763_ChIP-Seq_HESCs_Human1.18171268
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17955263
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17374198
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17333783
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.16563778
92* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15966383
93BCL6_27268052_Chip-Seq_Bcells_Human1.15699323
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14916162
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13347985
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12988778
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11879641
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.11049365
99* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09522126
100TFEB_21752829_ChIP-Seq_HELA_Human1.08819336
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08705934
102MYC_22102868_ChIP-Seq_BL_Human1.08165874
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08131737
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08131737
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08131737
106BCOR_27268052_Chip-Seq_Bcells_Human1.07594165
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06579187
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06502377
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06457966
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06367244
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05673551
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05569744
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04938336
114MAF_26560356_Chip-Seq_TH2_Human1.03981581
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03553383
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03257585
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02915002
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.01789206
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01588661
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01449043
121* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01101126
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00916400
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00749223
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00282850
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96546739
126MYC_18940864_ChIP-ChIP_HL60_Human0.94717494
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94243304
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93268007
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88794482
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.88267566
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87042200
132* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86927993
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.85281222
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82633204
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80811446
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80661573
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80468013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.12624592
2MP0004957_abnormal_blastocyst_morpholog4.98262426
3MP0003111_abnormal_nucleus_morphology4.55552723
4MP0010094_abnormal_chromosome_stability4.32677328
5MP0003077_abnormal_cell_cycle4.09165294
6MP0008057_abnormal_DNA_replication3.93460429
7MP0008058_abnormal_DNA_repair3.64417990
8MP0005058_abnormal_lysosome_morphology3.52575785
9MP0005451_abnormal_body_composition3.11838917
10MP0008932_abnormal_embryonic_tissue2.98036563
11MP0008007_abnormal_cellular_replicative2.89506558
12MP0003123_paternal_imprinting2.75031305
13MP0003786_premature_aging2.74264515
14MP0003806_abnormal_nucleotide_metabolis2.42634756
15MP0001730_embryonic_growth_arrest2.39714307
16MP0003718_maternal_effect2.34267067
17MP0005464_abnormal_platelet_physiology2.23270400
18MP0009840_abnormal_foam_cell2.20833049
19MP0000350_abnormal_cell_proliferation2.14249425
20MP0002877_abnormal_melanocyte_morpholog2.08003724
21MP0004858_abnormal_nervous_system2.00504082
22MP0003705_abnormal_hypodermis_morpholog1.97502285
23MP0002396_abnormal_hematopoietic_system1.86885156
24MP0008877_abnormal_DNA_methylation1.86698895
25MP0000678_abnormal_parathyroid_gland1.86205223
26MP0005670_abnormal_white_adipose1.83519720
27MP0005623_abnormal_meninges_morphology1.80391152
28MP0001697_abnormal_embryo_size1.70929323
29MP0001672_abnormal_embryogenesis/_devel1.69262076
30MP0005380_embryogenesis_phenotype1.69262076
31MP0010352_gastrointestinal_tract_polyps1.67932843
32MP0002080_prenatal_lethality1.62584128
33MP0003567_abnormal_fetal_cardiomyocyte1.61911325
34MP0003186_abnormal_redox_activity1.61506609
35MP0009278_abnormal_bone_marrow1.61298020
36MP0000490_abnormal_crypts_of1.61213300
37MP0003315_abnormal_perineum_morphology1.57547695
38MP0003191_abnormal_cellular_cholesterol1.55059032
39MP0001849_ear_inflammation1.53332165
40MP0000313_abnormal_cell_death1.52419568
41MP0003984_embryonic_growth_retardation1.49242658
42MP0006036_abnormal_mitochondrial_physio1.48179531
43MP0009333_abnormal_splenocyte_physiolog1.47807283
44MP0002085_abnormal_embryonic_tissue1.46328360
45MP0002088_abnormal_embryonic_growth/wei1.44393901
46MP0004133_heterotaxia1.40543158
47MP0006292_abnormal_olfactory_placode1.40077505
48MP0006035_abnormal_mitochondrial_morpho1.35668003
49MP0002160_abnormal_reproductive_system1.32480393
50MP0002019_abnormal_tumor_incidence1.31859485
51MP0000358_abnormal_cell_content/1.31759373
52MP0004185_abnormal_adipocyte_glucose1.30272444
53MP0009379_abnormal_foot_pigmentation1.29320992
54MP0002210_abnormal_sex_determination1.28637045
55MP0002132_abnormal_respiratory_system1.27904132
56MP0000343_altered_response_to1.27881063
57MP0002084_abnormal_developmental_patter1.24138631
58MP0002653_abnormal_ependyma_morphology1.23188806
59MP0002086_abnormal_extraembryonic_tissu1.18347242
60MP0010030_abnormal_orbit_morphology1.18130841
61MP0001145_abnormal_male_reproductive1.17503305
62MP0005257_abnormal_intraocular_pressure1.17224833
63MP0010307_abnormal_tumor_latency1.17040425
64MP0003566_abnormal_cell_adhesion1.16187153
65MP0000751_myopathy1.15700544
66MP0003075_altered_response_to1.14468677
67MP0000750_abnormal_muscle_regeneration1.14410634
68MP0001661_extended_life_span1.11541496
69MP0008260_abnormal_autophagy1.09590256
70MP0003119_abnormal_digestive_system1.09043929
71MP0005397_hematopoietic_system_phenotyp1.03557268
72MP0001545_abnormal_hematopoietic_system1.03557268
73MP0001881_abnormal_mammary_gland1.03466998
74MP0001293_anophthalmia1.02728622
75MP0004808_abnormal_hematopoietic_stem1.01751032
76MP0004197_abnormal_fetal_growth/weight/1.00760673
77MP0003941_abnormal_skin_development0.99883451
78MP0005360_urolithiasis0.99060211
79MP0005389_reproductive_system_phenotype0.98503460
80MP0005584_abnormal_enzyme/coenzyme_acti0.98289660
81MP0005666_abnormal_adipose_tissue0.96928126
82MP0000003_abnormal_adipose_tissue0.96606318
83MP0008995_early_reproductive_senescence0.95967984
84MP0004233_abnormal_muscle_weight0.95957855
85MP0000653_abnormal_sex_gland0.94643384
86MP0003121_genomic_imprinting0.94138149
87MP0001929_abnormal_gametogenesis0.93685944
88MP0005165_increased_susceptibility_to0.92621615
89MP0008438_abnormal_cutaneous_collagen0.92064424
90MP0002249_abnormal_larynx_morphology0.90226663
91MP0009672_abnormal_birth_weight0.88333707
92MP0005375_adipose_tissue_phenotype0.88219327
93MP0005266_abnormal_metabolism0.87904654
94MP0000681_abnormal_thyroid_gland0.84446525
95MP0002089_abnormal_postnatal_growth/wei0.82901011
96MP0003436_decreased_susceptibility_to0.82777057
97MP0005384_cellular_phenotype0.82694100
98MP0000703_abnormal_thymus_morphology0.81835655
99MP0003221_abnormal_cardiomyocyte_apopto0.81116228
100MP0002722_abnormal_immune_system0.80564361
101MP0001727_abnormal_embryo_implantation0.80215347
102MP0003763_abnormal_thymus_physiology0.79772615
103MP0002163_abnormal_gland_morphology0.79679626
104MP0000537_abnormal_urethra_morphology0.78371924
105MP0002139_abnormal_hepatobiliary_system0.77694428
106MP0004084_abnormal_cardiac_muscle0.77558586
107MP0003453_abnormal_keratinocyte_physiol0.76231325
108MP0002970_abnormal_white_adipose0.76217675
109MP0000689_abnormal_spleen_morphology0.75638929
110MP0000858_altered_metastatic_potential0.74237719
111MP0000759_abnormal_skeletal_muscle0.73533642
112MP0002796_impaired_skin_barrier0.72986333
113MP0003890_abnormal_embryonic-extraembry0.72936729
114MP0005075_abnormal_melanosome_morpholog0.72775450
115MP0005332_abnormal_amino_acid0.72504676
116MP0003172_abnormal_lysosome_physiology0.72193849
117MP0000747_muscle_weakness0.71530522
118MP0001853_heart_inflammation0.70686932
119MP0001119_abnormal_female_reproductive0.70469796
120MP0003136_yellow_coat_color0.70352388
121MP0005083_abnormal_biliary_tract0.68935078
122MP0000749_muscle_degeneration0.68027956
123MP0002398_abnormal_bone_marrow0.67596593
124MP0005621_abnormal_cell_physiology0.67043951
125MP0002111_abnormal_tail_morphology0.66712590
126MP0004510_myositis0.66119144
127MP0002938_white_spotting0.65418613
128MP0002148_abnormal_hypersensitivity_rea0.65047955
129MP0002269_muscular_atrophy0.64803422
130MP0005319_abnormal_enzyme/_coenzyme0.64189685
131MP0001919_abnormal_reproductive_system0.63769138
132MP0001529_abnormal_vocalization0.63728150
133MP0009697_abnormal_copulation0.62859512
134MP0000598_abnormal_liver_morphology0.62576402
135MP0003303_peritoneal_inflammation0.62388601
136MP0002429_abnormal_blood_cell0.62084370
137MP0008873_increased_physiological_sensi0.60917406
138MP0000609_abnormal_liver_physiology0.60583886
139MP0003646_muscle_fatigue0.59634027
140MP0005395_other_phenotype0.58662221
141MP0002127_abnormal_cardiovascular_syste0.58471954
142MP0002751_abnormal_autonomic_nervous0.56785943
143MP0003936_abnormal_reproductive_system0.56562713
144MP0001542_abnormal_bone_strength0.55105548
145MP0005501_abnormal_skin_physiology0.52588731
146MP0001764_abnormal_homeostasis0.52097548
147MP0008789_abnormal_olfactory_epithelium0.51774989
148MP0000477_abnormal_intestine_morphology0.49790510
149MP0005330_cardiomyopathy0.49299058
150MP0005023_abnormal_wound_healing0.49062819
151MP0003878_abnormal_ear_physiology0.48767833
152MP0005377_hearing/vestibular/ear_phenot0.48767833

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.34286023
2Abnormality of cells of the erythroid lineage (HP:0012130)5.30899470
3Abnormal number of erythroid precursors (HP:0012131)4.98114895
4Breast hypoplasia (HP:0003187)4.71566947
5Reticulocytopenia (HP:0001896)4.60595801
6Cerebral hypomyelination (HP:0006808)3.99178876
7Cholecystitis (HP:0001082)3.88694846
8Abnormal gallbladder physiology (HP:0012438)3.88694846
9Carpal bone hypoplasia (HP:0001498)3.84016301
10Rough bone trabeculation (HP:0100670)3.68804313
11Oral leukoplakia (HP:0002745)3.68385745
12Macrocytic anemia (HP:0001972)3.60914295
13Patellar aplasia (HP:0006443)3.35824856
14Aplastic anemia (HP:0001915)3.31393804
15Degeneration of anterior horn cells (HP:0002398)3.25428841
16Abnormality of the anterior horn cell (HP:0006802)3.25428841
17Ragged-red muscle fibers (HP:0003200)3.25386378
18Pallor (HP:0000980)3.19047622
19Aplasia/Hypoplasia of the patella (HP:0006498)3.18273566
20Acute necrotizing encephalopathy (HP:0006965)3.15008491
21Colon cancer (HP:0003003)3.12574375
22Selective tooth agenesis (HP:0001592)3.09594090
23Petechiae (HP:0000967)3.01886890
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01804553
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01804553
26Testicular atrophy (HP:0000029)2.98931862
27Microretrognathia (HP:0000308)2.97474240
28Abnormal mitochondria in muscle tissue (HP:0008316)2.92573756
29Increased muscle lipid content (HP:0009058)2.90684588
30Mitochondrial inheritance (HP:0001427)2.89211169
31Multiple enchondromatosis (HP:0005701)2.88286667
32Hepatocellular necrosis (HP:0001404)2.86963482
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.85671592
34Achilles tendon contracture (HP:0001771)2.85594962
35Trismus (HP:0000211)2.81266518
36Increased serum lactate (HP:0002151)2.80445655
37Increased CSF lactate (HP:0002490)2.79931541
38Absent thumb (HP:0009777)2.72589868
39Abnormality of the Achilles tendon (HP:0005109)2.70428448
40Premature ovarian failure (HP:0008209)2.69225359
41Abnormal trabecular bone morphology (HP:0100671)2.68492088
42Absent radius (HP:0003974)2.65236360
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61647188
44Hepatic necrosis (HP:0002605)2.60650464
45Premature graying of hair (HP:0002216)2.60497303
463-Methylglutaconic aciduria (HP:0003535)2.59565997
47Progressive muscle weakness (HP:0003323)2.58630198
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57816149
49Ependymoma (HP:0002888)2.56412129
50Secondary amenorrhea (HP:0000869)2.55330110
51Vertebral compression fractures (HP:0002953)2.50439427
52Meckel diverticulum (HP:0002245)2.49853898
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49509136
54Hepatosplenomegaly (HP:0001433)2.46369067
55Type I transferrin isoform profile (HP:0003642)2.46217425
56Abnormality of the preputium (HP:0100587)2.45709425
57Cerebral edema (HP:0002181)2.45694491
58Purpura (HP:0000979)2.45384690
59Absent forearm bone (HP:0003953)2.44670870
60Aplasia involving forearm bones (HP:0009822)2.44670870
61Neoplasm of the pancreas (HP:0002894)2.44500433
62Acute encephalopathy (HP:0006846)2.42887312
63Hypertensive crisis (HP:0100735)2.41841560
64Agnosia (HP:0010524)2.41530431
65Abnormality of the ileum (HP:0001549)2.40951226
66Horseshoe kidney (HP:0000085)2.38538807
67Renal Fanconi syndrome (HP:0001994)2.36738551
68Reduced subcutaneous adipose tissue (HP:0003758)2.36481064
69Chromsome breakage (HP:0040012)2.35831691
70CNS hypomyelination (HP:0003429)2.32851151
71Reduced antithrombin III activity (HP:0001976)2.31323755
72Abnormality of the labia minora (HP:0012880)2.29227790
73Increased hepatocellular lipid droplets (HP:0006565)2.29193436
74Exercise intolerance (HP:0003546)2.27679954
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27635733
76Cholelithiasis (HP:0001081)2.27267024
77Impulsivity (HP:0100710)2.27036332
78Progressive macrocephaly (HP:0004481)2.26049095
79Opisthotonus (HP:0002179)2.25380400
80Increased serum pyruvate (HP:0003542)2.23874627
81Abnormality of glycolysis (HP:0004366)2.23874627
82Microvesicular hepatic steatosis (HP:0001414)2.23123372
83Cellular immunodeficiency (HP:0005374)2.22482180
84Sparse eyelashes (HP:0000653)2.20899755
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20474456
86Medulloblastoma (HP:0002885)2.19392082
87Stenosis of the external auditory canal (HP:0000402)2.18033336
88Bone marrow hypocellularity (HP:0005528)2.17850923
89Abnormal number of incisors (HP:0011064)2.16342667
90Cleft eyelid (HP:0000625)2.15609372
91Hyperacusis (HP:0010780)2.12394190
9211 pairs of ribs (HP:0000878)2.11034118
93Lactic acidosis (HP:0003128)2.10724507
94Pancytopenia (HP:0001876)2.07886717
95Triphalangeal thumb (HP:0001199)2.06047671
96Abnormal protein glycosylation (HP:0012346)2.04290106
97Abnormal glycosylation (HP:0012345)2.04290106
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04290106
99Abnormal protein N-linked glycosylation (HP:0012347)2.04290106
100Hypertriglyceridemia (HP:0002155)2.04003311
101Exertional dyspnea (HP:0002875)2.02884444
102Respiratory failure (HP:0002878)2.02294092
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.01831093
104Muscle fiber atrophy (HP:0100295)2.00186170
105Myopathic facies (HP:0002058)2.00040768
106Prolonged neonatal jaundice (HP:0006579)1.99915810
107Distal lower limb muscle weakness (HP:0009053)1.99719611
108Postnatal microcephaly (HP:0005484)1.98322580
109Myelodysplasia (HP:0002863)1.98154432
110Facial cleft (HP:0002006)1.97966320
111Dicarboxylic aciduria (HP:0003215)1.97452351
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97452351
113Abnormality of chromosome stability (HP:0003220)1.97439387
114Lipid accumulation in hepatocytes (HP:0006561)1.97397762
115Broad distal phalanx of finger (HP:0009836)1.96396864
116Unsteady gait (HP:0002317)1.95894754
117Supernumerary spleens (HP:0009799)1.95319861
118Glossoptosis (HP:0000162)1.94833109
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94575642
120Small intestinal stenosis (HP:0012848)1.94069617
121Duodenal stenosis (HP:0100867)1.94069617
122Abnormal gallbladder morphology (HP:0012437)1.93675493
123CNS demyelination (HP:0007305)1.93660125
124Generalized amyotrophy (HP:0003700)1.92310365
125Difficulty climbing stairs (HP:0003551)1.92242948
126Premature rupture of membranes (HP:0001788)1.91528163
127Emotional lability (HP:0000712)1.91323422
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.90462735
129Tracheoesophageal fistula (HP:0002575)1.90430764
130Entropion (HP:0000621)1.90210171
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90103720
132Fasciculations (HP:0002380)1.89101864
133Premature skin wrinkling (HP:0100678)1.88982503
134Megaloblastic anemia (HP:0001889)1.88599548
135Abnormality of the gallbladder (HP:0005264)1.88300360
136Increased intramyocellular lipid droplets (HP:0012240)1.87498190
137Type 2 muscle fiber atrophy (HP:0003554)1.87377408
138Abnormality of the umbilical cord (HP:0010881)1.87371062
139Respiratory difficulties (HP:0002880)1.86043275
140Fatigue (HP:0012378)1.85741795
141Truncus arteriosus (HP:0001660)1.84984087
142Muscle stiffness (HP:0003552)1.84808165
143Increased serum ferritin (HP:0003281)1.84648472
144Hyperthyroidism (HP:0000836)1.80346312
145Distal lower limb amyotrophy (HP:0008944)1.79534750
146Abnormality of reticulocytes (HP:0004312)1.77507558
147Rhabdomyolysis (HP:0003201)1.76981009
148Nausea (HP:0002018)1.73163558
149Abnormalities of placenta or umbilical cord (HP:0001194)1.72827917
150Insomnia (HP:0100785)1.72255125
151Generalized aminoaciduria (HP:0002909)1.66541669
152Ileus (HP:0002595)1.64958075
153Abnormal umbilical cord blood vessels (HP:0011403)1.64845095
154Single umbilical artery (HP:0001195)1.64845095
155Abnormality of the fetal cardiovascular system (HP:0010948)1.64845095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.77423792
2VRK24.69966429
3WEE14.65762793
4NME23.48842039
5EIF2AK13.13557110
6STK163.08830491
7SMG12.90809922
8TSSK62.89111449
9CDC72.77796665
10PLK42.40430985
11SRPK12.28164468
12BRSK22.14386995
13VRK12.04135718
14EPHA22.03768513
15TRIB32.02532178
16NEK12.01845402
17EIF2AK31.98348928
18ACVR1B1.98127134
19NEK21.97127357
20TTK1.94628140
21TESK21.91049265
22PLK11.87301560
23ERN11.83569327
24PIM21.78208275
25RPS6KB21.69573173
26DYRK31.60785426
27CDK71.59114230
28PLK31.50932966
29AURKA1.47241064
30NME11.44188936
31AURKB1.42184982
32PASK1.41559059
33BRSK11.41081729
34MKNK11.36056320
35ICK1.31612448
36ATR1.30404042
37BRAF1.30168827
38PAK41.23277561
39CCNB11.20848816
40ARAF1.20358443
41TLK11.17137854
42BCKDK1.17064354
43MAP3K81.14744001
44CHEK21.12930877
45KDR1.12072045
46RPS6KA41.11173117
47MAPKAPK31.08854061
48ZAK1.03068752
49PRPF4B1.02518687
50SIK11.01258712
51MAP3K111.00246590
52TGFBR10.99528843
53SCYL20.90436569
54PNCK0.89994186
55CHEK10.88783182
56PRKD30.87135429
57PAK10.86518763
58BMX0.85540642
59AKT30.84911544
60CDK80.83108640
61CDK40.81875220
62PRKCI0.80977504
63MKNK20.80575316
64LMTK20.79308608
65PIM10.77378522
66CSNK2A10.77036636
67CSNK2A20.75585938
68MAP2K30.72819937
69PBK0.71283393
70LRRK20.71074120
71IRAK30.66957654
72DYRK20.65913273
73CDK11A0.65718084
74CSNK1G30.65402691
75MAP3K100.64450022
76MST40.63404646
77STK40.62770005
78STK100.62670996
79CDK20.61170441
80TAOK20.60935880
81PDK30.60351642
82PDK40.60351642
83CDK140.59356975
84CDK190.59070631
85MOS0.58422059
86TESK10.58181764
87CDK150.57737425
88EEF2K0.57621807
89STK38L0.56439967
90ILK0.55271425
91FLT30.55263690
92CDK180.53637997
93PDK20.52954160
94GRK50.52884742
95DAPK10.51811094
96EIF2AK20.51585908
97LATS20.49994399
98MAPK110.49878727
99ATM0.49705418
100RPS6KA50.49442201
101TBK10.48809583
102TAOK10.47564253
103ABL20.44334265
104MAP3K30.44106960
105PTK20.43989407
106CDK10.39328434
107CDK90.38444056
108TAF10.37912291
109MAP2K20.36137930
110AKT20.35715060
111ALK0.35101923
112TTN0.34956464
113RAF10.34674898
114PDPK10.34422884
115PRKG20.34366438
116PRKD20.34330600
117CSNK1A1L0.34005168
118CAMK2G0.31028226
119CLK10.29982623
120MAP3K10.29485102
121EPHB20.28009648
122CSNK1E0.27624119
123MELK0.27197918
124IKBKB0.27168935
125LIMK10.26986541
126MYLK0.26801544
127MAP4K10.24457327
128MAP3K50.24264928
129MAPKAPK20.23838854
130GRK60.22713261
131RPS6KL10.21914869
132RPS6KC10.21914869
133RPS6KA60.21217990
134DAPK30.19849202
135ZAP700.19346886

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.59190856
2DNA replication_Homo sapiens_hsa030304.53219694
3Proteasome_Homo sapiens_hsa030504.52620847
4Mismatch repair_Homo sapiens_hsa034303.95796789
5* RNA polymerase_Homo sapiens_hsa030203.86276607
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74593831
7Spliceosome_Homo sapiens_hsa030403.18415048
8RNA transport_Homo sapiens_hsa030132.96880416
9Base excision repair_Homo sapiens_hsa034102.82130059
10Nucleotide excision repair_Homo sapiens_hsa034202.77915106
11* Pyrimidine metabolism_Homo sapiens_hsa002402.73612993
12Homologous recombination_Homo sapiens_hsa034402.67860090
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35978712
14Cell cycle_Homo sapiens_hsa041102.15052240
15One carbon pool by folate_Homo sapiens_hsa006702.13668343
16Fatty acid elongation_Homo sapiens_hsa000622.08284057
17Basal transcription factors_Homo sapiens_hsa030221.86816573
18Oxidative phosphorylation_Homo sapiens_hsa001901.83825307
19Parkinsons disease_Homo sapiens_hsa050121.79955626
20Fanconi anemia pathway_Homo sapiens_hsa034601.77642698
21RNA degradation_Homo sapiens_hsa030181.72514107
22Huntingtons disease_Homo sapiens_hsa050161.54154719
23* Purine metabolism_Homo sapiens_hsa002301.52208294
24Non-homologous end-joining_Homo sapiens_hsa034501.50904166
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34152473
26p53 signaling pathway_Homo sapiens_hsa041151.33484263
27Protein export_Homo sapiens_hsa030601.25079731
28mRNA surveillance pathway_Homo sapiens_hsa030151.23518167
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22782688
30Folate biosynthesis_Homo sapiens_hsa007901.19813636
31Other glycan degradation_Homo sapiens_hsa005111.18702724
32Vitamin B6 metabolism_Homo sapiens_hsa007501.18222999
33* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17404712
34Sulfur metabolism_Homo sapiens_hsa009201.13215824
35* Epstein-Barr virus infection_Homo sapiens_hsa051691.12777882
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11082630
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09548892
38Phenylalanine metabolism_Homo sapiens_hsa003601.05458263
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.04612052
40Alzheimers disease_Homo sapiens_hsa050100.96294568
41Biosynthesis of amino acids_Homo sapiens_hsa012300.94595324
42Pentose phosphate pathway_Homo sapiens_hsa000300.94569320
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94436721
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92854170
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89010230
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.88341384
47Sulfur relay system_Homo sapiens_hsa041220.85214862
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.82781364
49Glutathione metabolism_Homo sapiens_hsa004800.81276694
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.77537540
51Oocyte meiosis_Homo sapiens_hsa041140.72891511
52Tyrosine metabolism_Homo sapiens_hsa003500.72121267
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72094048
54Fructose and mannose metabolism_Homo sapiens_hsa000510.70459404
55Carbon metabolism_Homo sapiens_hsa012000.70280984
56Regulation of autophagy_Homo sapiens_hsa041400.64882213
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62089575
58Fatty acid metabolism_Homo sapiens_hsa012120.60995626
59Antigen processing and presentation_Homo sapiens_hsa046120.58183569
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55856759
61Arginine biosynthesis_Homo sapiens_hsa002200.55175271
62Lysosome_Homo sapiens_hsa041420.54479978
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53961503
64Herpes simplex infection_Homo sapiens_hsa051680.53271172
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53219530
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49336509
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49265621
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48723341
69Steroid biosynthesis_Homo sapiens_hsa001000.48143881
70Selenocompound metabolism_Homo sapiens_hsa004500.47598853
71Viral carcinogenesis_Homo sapiens_hsa052030.47496443
72* Metabolic pathways_Homo sapiens_hsa011000.47255547
73Cardiac muscle contraction_Homo sapiens_hsa042600.44016648
74HTLV-I infection_Homo sapiens_hsa051660.41062275
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41045854
76Thyroid cancer_Homo sapiens_hsa052160.40952340
77Systemic lupus erythematosus_Homo sapiens_hsa053220.40899529
78Galactose metabolism_Homo sapiens_hsa000520.40828065
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39307362
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39155031
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38427971
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38364701
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37648779
84Peroxisome_Homo sapiens_hsa041460.36899308
85Legionellosis_Homo sapiens_hsa051340.34815240
86Collecting duct acid secretion_Homo sapiens_hsa049660.32241607
87Arachidonic acid metabolism_Homo sapiens_hsa005900.31125640
88Arginine and proline metabolism_Homo sapiens_hsa003300.30577264
89Prion diseases_Homo sapiens_hsa050200.29996259
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29005403
91beta-Alanine metabolism_Homo sapiens_hsa004100.27741199
92Fatty acid degradation_Homo sapiens_hsa000710.27264885
93N-Glycan biosynthesis_Homo sapiens_hsa005100.26907211
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23925967
95Salmonella infection_Homo sapiens_hsa051320.23531402
96HIF-1 signaling pathway_Homo sapiens_hsa040660.22197104
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22176777
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21963981
99Apoptosis_Homo sapiens_hsa042100.21105903
100Synaptic vesicle cycle_Homo sapiens_hsa047210.20240506
101Shigellosis_Homo sapiens_hsa051310.19581704
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18979729
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.17047769
104Hippo signaling pathway_Homo sapiens_hsa043900.15952287
105Endocytosis_Homo sapiens_hsa041440.14832550
106Small cell lung cancer_Homo sapiens_hsa052220.13351526
107Acute myeloid leukemia_Homo sapiens_hsa052210.11713712
108Pyruvate metabolism_Homo sapiens_hsa006200.10383403
109Primary immunodeficiency_Homo sapiens_hsa053400.09260157
110Fat digestion and absorption_Homo sapiens_hsa049750.09135543
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09132537
112Renin-angiotensin system_Homo sapiens_hsa046140.08432754
113Bladder cancer_Homo sapiens_hsa052190.08121802
114TGF-beta signaling pathway_Homo sapiens_hsa043500.07363075
115Basal cell carcinoma_Homo sapiens_hsa052170.06501613
116Linoleic acid metabolism_Homo sapiens_hsa005910.06477589
117MicroRNAs in cancer_Homo sapiens_hsa052060.03976293
118Hedgehog signaling pathway_Homo sapiens_hsa043400.03593726
119Pathways in cancer_Homo sapiens_hsa052000.01728005
120Notch signaling pathway_Homo sapiens_hsa043300.01503645
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.00873882
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00536456
123Tight junction_Homo sapiens_hsa04530-0.0416369
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0351678
125Hepatitis B_Homo sapiens_hsa05161-0.0170905
126Measles_Homo sapiens_hsa05162-0.0134489
127Influenza A_Homo sapiens_hsa05164-0.0065505
128Vibrio cholerae infection_Homo sapiens_hsa05110-0.0043884
129Alcoholism_Homo sapiens_hsa05034-0.0019459

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