POLR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.90166560
2pre-miRNA processing (GO:0031054)4.88733978
3nuclear pore organization (GO:0006999)4.80214237
4heterochromatin organization (GO:0070828)4.63998248
5DNA unwinding involved in DNA replication (GO:0006268)4.23916608
6regulation of histone H3-K27 methylation (GO:0061085)3.86681299
7negative regulation of histone methylation (GO:0031061)3.81649316
8histone H3-K36 demethylation (GO:0070544)3.78913621
9mitotic sister chromatid cohesion (GO:0007064)3.78540398
10protein localization to kinetochore (GO:0034501)3.77048789
11mitotic nuclear envelope disassembly (GO:0007077)3.73951058
12pore complex assembly (GO:0046931)3.66987327
13glucocorticoid receptor signaling pathway (GO:0042921)3.66981296
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57148042
15mRNA stabilization (GO:0048255)3.57142144
16RNA stabilization (GO:0043489)3.57142144
17negative regulation of erythrocyte differentiation (GO:0045647)3.56239368
18adherens junction assembly (GO:0034333)3.55444001
19regulation of translational fidelity (GO:0006450)3.54953112
20regulation of RNA export from nucleus (GO:0046831)3.54371252
21membrane disassembly (GO:0030397)3.52255827
22nuclear envelope disassembly (GO:0051081)3.52255827
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50191975
24regulation of posttranscriptional gene silencing (GO:0060147)3.49496585
25regulation of gene silencing by miRNA (GO:0060964)3.49496585
26regulation of gene silencing by RNA (GO:0060966)3.49496585
27dosage compensation (GO:0007549)3.38483102
28cell-substrate adherens junction assembly (GO:0007045)3.37604984
29focal adhesion assembly (GO:0048041)3.37604984
30mitotic chromosome condensation (GO:0007076)3.36554076
31chromatin assembly (GO:0031497)3.36547423
32paraxial mesoderm development (GO:0048339)3.35805085
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34501489
34regulation of histone H3-K9 methylation (GO:0051570)3.33722998
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.33685816
36sister chromatid segregation (GO:0000819)3.30054338
37DNA duplex unwinding (GO:0032508)3.28285574
38DNA geometric change (GO:0032392)3.26672609
39NLS-bearing protein import into nucleus (GO:0006607)3.22021915
40gene silencing by RNA (GO:0031047)3.19808408
41negative regulation of mRNA processing (GO:0050686)3.18385883
42cytoplasmic mRNA processing body assembly (GO:0033962)3.17463208
43histone demethylation (GO:0016577)3.17050399
44negative regulation of mRNA metabolic process (GO:1903312)3.16297962
45protein localization to chromosome, centromeric region (GO:0071459)3.14495194
46histone H4-K12 acetylation (GO:0043983)3.13002779
47mitotic sister chromatid segregation (GO:0000070)3.12924018
48positive regulation of SMAD protein import into nucleus (GO:0060391)3.12756486
49histone lysine demethylation (GO:0070076)3.11184651
50gene silencing (GO:0016458)3.10974013
51negative regulation of RNA splicing (GO:0033119)3.10382713
52embryonic process involved in female pregnancy (GO:0060136)3.09224681
53Golgi transport vesicle coating (GO:0048200)3.09051722
54COPI coating of Golgi vesicle (GO:0048205)3.09051722
55positive regulation of gene expression, epigenetic (GO:0045815)3.08122761
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.05469813
57regulation of sister chromatid cohesion (GO:0007063)3.04468705
58regulation of chromatin binding (GO:0035561)3.03586497
59intracellular estrogen receptor signaling pathway (GO:0030520)3.01343663
60alternative mRNA splicing, via spliceosome (GO:0000380)3.01210257
61activation of Rac GTPase activity (GO:0032863)3.00141551
62regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99186887
63stress granule assembly (GO:0034063)2.95219668
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94545030
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94062340
66histone H2A monoubiquitination (GO:0035518)2.93819777
67protein-DNA complex disassembly (GO:0032986)2.92662125
68nucleosome disassembly (GO:0006337)2.92662125
69DNA replication-dependent nucleosome assembly (GO:0006335)2.92396946
70DNA replication-dependent nucleosome organization (GO:0034723)2.92396946
71peptidyl-lysine dimethylation (GO:0018027)2.91591225
72corticosteroid receptor signaling pathway (GO:0031958)2.91216550
73regulation of mitotic spindle organization (GO:0060236)2.90059001
74cell-substrate junction assembly (GO:0007044)2.89813429
75nuclear envelope organization (GO:0006998)2.85910406
76protein localization to endosome (GO:0036010)2.85184417
77positive regulation of chromosome segregation (GO:0051984)2.84761687
78trophectodermal cell differentiation (GO:0001829)2.84126722
79chromatin silencing (GO:0006342)2.82212784
80positive regulation of histone deacetylation (GO:0031065)2.81335876
81protein demethylation (GO:0006482)2.79875667
82protein dealkylation (GO:0008214)2.79875667
83folic acid-containing compound biosynthetic process (GO:0009396)2.79628250
84histone H3-K9 demethylation (GO:0033169)2.79514665
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78927715
86regulation of nucleobase-containing compound transport (GO:0032239)2.78762113
87cellular response to epidermal growth factor stimulus (GO:0071364)2.78061054
88regulation of spindle organization (GO:0090224)2.76985427
89regulation of mRNA stability (GO:0043488)2.76019772
90negative regulation of cell size (GO:0045792)2.75727319
91response to laminar fluid shear stress (GO:0034616)2.75444200
92cellular response to virus (GO:0098586)2.74076560
93DNA replication checkpoint (GO:0000076)2.73197550
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72658030
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72658030
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.72658030
973-UTR-mediated mRNA stabilization (GO:0070935)2.72298868
98regulation of SMAD protein import into nucleus (GO:0060390)2.71477159
99DNA conformation change (GO:0071103)2.69885399
100translesion synthesis (GO:0019985)2.69746628
101regulation of NFAT protein import into nucleus (GO:0051532)2.68510748
102regulation of translational termination (GO:0006449)2.68245331
103regulation of hippo signaling (GO:0035330)2.67219746
104maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66898339
105negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.66700151
106negative regulation of histone modification (GO:0031057)2.66515709
107nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.65525659
108regulation of early endosome to late endosome transport (GO:2000641)2.64878914
109skin morphogenesis (GO:0043589)2.64317856
110protein localization to chromosome (GO:0034502)2.62593071
111chromosome condensation (GO:0030261)2.62081851
112regulation of DNA damage checkpoint (GO:2000001)2.61967582
113protein retention in ER lumen (GO:0006621)2.61627405
114negative regulation of gene expression, epigenetic (GO:0045814)2.60461808
115negative regulation of myotube differentiation (GO:0010832)2.59817604
116thymic T cell selection (GO:0045061)2.59734751
117histone H3-K9 methylation (GO:0051567)2.59209745
118histone H4-K8 acetylation (GO:0043982)2.58825359
119histone H4-K5 acetylation (GO:0043981)2.58825359
120regulation of RNA stability (GO:0043487)2.58791145
121histone H3-K4 methylation (GO:0051568)2.58753511
122regulation of stem cell maintenance (GO:2000036)2.58220469
123regulation of gene silencing (GO:0060968)2.58047160
124semaphorin-plexin signaling pathway (GO:0071526)2.57886871
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57160925
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.57097412
127snRNA metabolic process (GO:0016073)2.56535571
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55665305
129response to epidermal growth factor (GO:0070849)2.55506523
130histone H4-K16 acetylation (GO:0043984)2.55080577
131mRNA transport (GO:0051028)2.54948321
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54326427
133negative regulation of chromatin modification (GO:1903309)2.52475280
134establishment of apical/basal cell polarity (GO:0035089)2.51312746
135chromatin assembly or disassembly (GO:0006333)2.50650835
136modulation by virus of host process (GO:0019054)2.50239411
137epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49900856
138hippo signaling (GO:0035329)2.49716248
139negative regulation of DNA repair (GO:0045738)2.49621067
140protein export from nucleus (GO:0006611)2.49335761
141modulation by symbiont of host cellular process (GO:0044068)2.48525556
142polarized epithelial cell differentiation (GO:0030859)2.48422548
143apoptotic process involved in morphogenesis (GO:0060561)2.47219431
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46685764
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.45854175
146basement membrane organization (GO:0071711)2.41771598
147embryonic eye morphogenesis (GO:0048048)2.40899960
148regulation of ARF protein signal transduction (GO:0032012)2.39019100
149mannose metabolic process (GO:0006013)2.37400295
150response to muramyl dipeptide (GO:0032495)2.37222488
151stress fiber assembly (GO:0043149)2.35509874
152positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34847139
153embryonic camera-type eye morphogenesis (GO:0048596)2.33419444
154negative regulation of striated muscle cell differentiation (GO:0051154)2.33312774
155neural tube development (GO:0021915)2.33060394
156positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.31567332
157eye morphogenesis (GO:0048592)2.31556724
158protein localization to microtubule (GO:0035372)2.30979257
159positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.30557513
160modulation by virus of host morphology or physiology (GO:0019048)2.30497681
161atrioventricular valve morphogenesis (GO:0003181)2.30147302
162activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27908362
163regulation of histone methylation (GO:0031060)2.25731799
164coronary vasculature morphogenesis (GO:0060977)2.25444525
165maternal placenta development (GO:0001893)2.25041353
166positive regulation of nuclease activity (GO:0032075)2.24178664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97907392
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.27331695
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.17994233
4MYC_22102868_ChIP-Seq_BL_Human3.61797839
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07129685
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87841283
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68971890
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66281415
9VDR_21846776_ChIP-Seq_THP-1_Human2.29083043
10LXR_22292898_ChIP-Seq_THP-1_Human2.24515481
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20731286
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.15036790
13TCF7_22412390_ChIP-Seq_EML_Mouse2.03868322
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02606044
15KDM2B_26808549_Chip-Seq_K562_Human1.98277788
16CIITA_25753668_ChIP-Seq_RAJI_Human1.96339810
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94448296
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89588322
19KDM2B_26808549_Chip-Seq_DND41_Human1.88501208
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83889888
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.83627564
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80685653
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79775655
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76238697
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.68213662
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67400570
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.64716255
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62799543
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60462422
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58956729
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55839756
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54328841
33* UTX_26944678_Chip-Seq_JUKART_Human1.54248223
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54217644
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53076541
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52847464
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52578500
38* AR_21909140_ChIP-Seq_LNCAP_Human1.51663517
39MAF_26560356_Chip-Seq_TH1_Human1.51417579
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.50582835
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49744067
42* XRN2_22483619_ChIP-Seq_HELA_Human1.47961750
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46292417
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44472558
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42935349
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41966661
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40918899
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40443295
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40443295
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40443295
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37804624
52* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36450736
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36120994
54KDM5A_27292631_Chip-Seq_BREAST_Human1.35225486
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33919091
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33645076
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32692043
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32274273
59NCOR1_26117541_ChIP-Seq_K562_Human1.30613429
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.30476592
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28188334
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28003508
63* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27286428
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26929581
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25775737
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24647482
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24162103
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23383681
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.21388590
70P68_20966046_ChIP-Seq_HELA_Human1.21387818
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19790277
72* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18812563
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.18749541
74* SMC4_20622854_ChIP-Seq_HELA_Human1.18440862
75* TFEB_21752829_ChIP-Seq_HELA_Human1.18190138
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.18001444
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17132055
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17069163
79CHD1_26751641_Chip-Seq_LNCaP_Human1.16099505
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.15898130
81MYB_26560356_Chip-Seq_TH1_Human1.15813038
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.15494403
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13809549
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13617626
85ATF3_27146783_Chip-Seq_COLON_Human1.13470917
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13339641
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12945656
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12333859
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.11988310
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11900111
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.11899056
92VDR_24763502_ChIP-Seq_THP-1_Human1.10912074
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10674954
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09261766
95ZNF263_19887448_ChIP-Seq_K562_Human1.07841090
96* MYB_26560356_Chip-Seq_TH2_Human1.07726722
97* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07725464
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07093009
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06515106
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06106634
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.05307940
102RACK7_27058665_Chip-Seq_MCF-7_Human1.04811359
103CLOCK_20551151_ChIP-Seq_293T_Human1.03327687
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02547659
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02546800
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02176227
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01940807
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00595585
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00455002
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00415366
111MAF_26560356_Chip-Seq_TH2_Human1.00123723
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00063202
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99788650
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99656512
115SCL_19346495_ChIP-Seq_HPC-7_Human0.99412114
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99046637
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98756328
118* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98449401
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98367021
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98341937
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98220890
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.97301319
123* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96089033
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.95854799
125* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95091792
126* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94566029
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94424808
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94146416
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93361960
130* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92960007
131* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91722702
132TP53_22127205_ChIP-Seq_IMR90_Human0.91556422
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90675248
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.90653023
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90123989
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89093186
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87656539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.34577608
2MP0010352_gastrointestinal_tract_polyps3.32470807
3MP0003705_abnormal_hypodermis_morpholog2.93623257
4MP0003111_abnormal_nucleus_morphology2.91132436
5MP0010094_abnormal_chromosome_stability2.72236781
6MP0003077_abnormal_cell_cycle2.52595609
7MP0004957_abnormal_blastocyst_morpholog2.46579716
8MP0005409_darkened_coat_color2.46446606
9MP0008057_abnormal_DNA_replication2.28058575
10MP0009278_abnormal_bone_marrow2.23293469
11MP0003693_abnormal_embryo_hatching2.22893530
12MP0001730_embryonic_growth_arrest2.17452288
13MP0010307_abnormal_tumor_latency2.13155997
14MP0005451_abnormal_body_composition2.11717572
15MP0000350_abnormal_cell_proliferation2.02969053
16MP0008438_abnormal_cutaneous_collagen2.00077967
17MP0004858_abnormal_nervous_system1.99509438
18MP0001348_abnormal_lacrimal_gland1.97852263
19* MP0004197_abnormal_fetal_growth/weight/1.86558230
20MP0002084_abnormal_developmental_patter1.86514254
21MP0001849_ear_inflammation1.86068710
22MP0008877_abnormal_DNA_methylation1.85368141
23MP0002009_preneoplasia1.82985708
24MP0001672_abnormal_embryogenesis/_devel1.82633936
25MP0005380_embryogenesis_phenotype1.82633936
26MP0003984_embryonic_growth_retardation1.79313091
27MP0003123_paternal_imprinting1.78682898
28MP0002088_abnormal_embryonic_growth/wei1.77085160
29MP0002396_abnormal_hematopoietic_system1.75520063
30MP0004808_abnormal_hematopoietic_stem1.74922895
31MP0002085_abnormal_embryonic_tissue1.71289711
32MP0003566_abnormal_cell_adhesion1.70436699
33MP0008007_abnormal_cellular_replicative1.69443153
34MP0000733_abnormal_muscle_development1.69355700
35MP0003300_gastrointestinal_ulcer1.69055397
36MP0002086_abnormal_extraembryonic_tissu1.68140442
37MP0000537_abnormal_urethra_morphology1.66440132
38MP0001697_abnormal_embryo_size1.66212443
39MP0008260_abnormal_autophagy1.65805026
40MP0000678_abnormal_parathyroid_gland1.62097951
41MP0005257_abnormal_intraocular_pressure1.54186946
42MP0003453_abnormal_keratinocyte_physiol1.53945366
43MP0002089_abnormal_postnatal_growth/wei1.52365580
44MP0010030_abnormal_orbit_morphology1.50913630
45MP0002249_abnormal_larynx_morphology1.49975492
46MP0002796_impaired_skin_barrier1.49129044
47MP0002653_abnormal_ependyma_morphology1.48532372
48MP0003121_genomic_imprinting1.45493503
49MP0002080_prenatal_lethality1.45008055
50MP0009053_abnormal_anal_canal1.41348238
51MP0008961_abnormal_basal_metabolism1.41230028
52MP0004272_abnormal_basement_membrane1.40279611
53MP0002060_abnormal_skin_morphology1.36796642
54MP0003119_abnormal_digestive_system1.34662631
55MP0003890_abnormal_embryonic-extraembry1.33941446
56MP0005623_abnormal_meninges_morphology1.33660751
57MP0005058_abnormal_lysosome_morphology1.32071749
58MP0000003_abnormal_adipose_tissue1.31742686
59MP0003172_abnormal_lysosome_physiology1.31360518
60MP0003567_abnormal_fetal_cardiomyocyte1.31359349
61MP0000703_abnormal_thymus_morphology1.30729612
62MP0003115_abnormal_respiratory_system1.30243068
63MP0008058_abnormal_DNA_repair1.29813669
64MP0000428_abnormal_craniofacial_morphol1.25579236
65MP0005023_abnormal_wound_healing1.25498584
66MP0005501_abnormal_skin_physiology1.25413744
67MP0000490_abnormal_crypts_of1.24214542
68MP0001915_intracranial_hemorrhage1.23261449
69MP0005397_hematopoietic_system_phenotyp1.22731155
70MP0001545_abnormal_hematopoietic_system1.22731155
71MP0003436_decreased_susceptibility_to1.20688579
72MP0003303_peritoneal_inflammation1.19904146
73MP0002925_abnormal_cardiovascular_devel1.19306201
74MP0008932_abnormal_embryonic_tissue1.18902531
75MP0003091_abnormal_cell_migration1.15203058
76MP0003283_abnormal_digestive_organ1.14837733
77MP0004264_abnormal_extraembryonic_tissu1.14516413
78MP0005375_adipose_tissue_phenotype1.14273585
79MP0001346_abnormal_lacrimal_gland1.14195461
80MP0000569_abnormal_digit_pigmentation1.12472154
81MP0005666_abnormal_adipose_tissue1.12465186
82MP0003329_amyloid_beta_deposits1.09450759
83MP0004233_abnormal_muscle_weight1.09313969
84MP0009703_decreased_birth_body1.08888542
85MP0002019_abnormal_tumor_incidence1.06323454
86MP0009672_abnormal_birth_weight1.06284267
87MP0000313_abnormal_cell_death1.05762644
88MP0002877_abnormal_melanocyte_morpholog1.05735040
89MP0002697_abnormal_eye_size1.04791009
90MP0001293_anophthalmia1.04335257
91MP0000579_abnormal_nail_morphology1.03075447
92MP0003763_abnormal_thymus_physiology1.02573611
93* MP0002398_abnormal_bone_marrow1.00899436
94MP0003935_abnormal_craniofacial_develop1.00105450
95MP0004381_abnormal_hair_follicle0.98628333
96MP0002092_abnormal_eye_morphology0.98323288
97MP0010234_abnormal_vibrissa_follicle0.94914716
98MP0002722_abnormal_immune_system0.92885372
99MP0001958_emphysema0.92548906
100MP0000432_abnormal_head_morphology0.92080316
101MP0005621_abnormal_cell_physiology0.91945160
102MP0009931_abnormal_skin_appearance0.91618544
103MP0002111_abnormal_tail_morphology0.91236914
104MP0005275_abnormal_skin_tensile0.90697148
105MP0008995_early_reproductive_senescence0.87906405
106MP0004185_abnormal_adipocyte_glucose0.87894808
107MP0001216_abnormal_epidermal_layer0.87823287
108MP0003942_abnormal_urinary_system0.85921612
109MP0010630_abnormal_cardiac_muscle0.85903306
110MP0003786_premature_aging0.85710131
111MP0000266_abnormal_heart_morphology0.84579481
112MP0000566_synostosis0.82807362
113MP0008770_decreased_survivor_rate0.80670885
114MP0002166_altered_tumor_susceptibility0.80309118
115MP0003385_abnormal_body_wall0.79917979
116MP0000689_abnormal_spleen_morphology0.78711851
117MP0002210_abnormal_sex_determination0.78023699
118MP0009333_abnormal_splenocyte_physiolog0.76960316
119MP0005384_cellular_phenotype0.76844317
120MP0002098_abnormal_vibrissa_morphology0.76790759
121MP0000477_abnormal_intestine_morphology0.76091298
122MP0002932_abnormal_joint_morphology0.75460343
123MP0006054_spinal_hemorrhage0.75196294
124MP0000759_abnormal_skeletal_muscle0.74822563
125MP0003448_altered_tumor_morphology0.74262986
126MP0001784_abnormal_fluid_regulation0.73751438
127MP0004087_abnormal_muscle_fiber0.73163232
128MP0003937_abnormal_limbs/digits/tail_de0.72805655
129MP0001145_abnormal_male_reproductive0.72182929
130MP0000858_altered_metastatic_potential0.71777847
131MP0004947_skin_inflammation0.70588283
132MP0003279_aneurysm0.70137101
133MP0000767_abnormal_smooth_muscle0.69886108
134MP0001286_abnormal_eye_development0.68353562
135* MP0002429_abnormal_blood_cell0.67868979

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.36267174
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.36267174
3Abnormality of the fingertips (HP:0001211)3.36218978
4Obstructive sleep apnea (HP:0002870)3.31777024
5Ependymoma (HP:0002888)3.27138880
6Long eyelashes (HP:0000527)3.07551901
7Broad face (HP:0000283)3.06842532
8Hyperacusis (HP:0010780)3.03786850
9Deviation of the thumb (HP:0009603)2.81118717
10Increased nuchal translucency (HP:0010880)2.80356201
11Astrocytoma (HP:0009592)2.72336942
12Abnormality of the astrocytes (HP:0100707)2.72336942
13Proximal placement of thumb (HP:0009623)2.72069420
14Pseudobulbar signs (HP:0002200)2.68139757
15Cerebral aneurysm (HP:0004944)2.62838298
16Premature rupture of membranes (HP:0001788)2.61038298
17Shallow orbits (HP:0000586)2.60481554
18Selective tooth agenesis (HP:0001592)2.51749479
19Abnormality of the 4th metacarpal (HP:0010012)2.50053359
20Renal duplication (HP:0000075)2.47061459
21Long palpebral fissure (HP:0000637)2.45941490
22Volvulus (HP:0002580)2.45193137
23Heterotopia (HP:0002282)2.44103251
24Trigonocephaly (HP:0000243)2.43426394
25Urethral obstruction (HP:0000796)2.41431496
26Dysmetric saccades (HP:0000641)2.39410233
27Medulloblastoma (HP:0002885)2.31929436
28Increased density of long bones (HP:0006392)2.31675583
29Ankle contracture (HP:0006466)2.30269521
30Prominent nose (HP:0000448)2.30071403
31Macroorchidism (HP:0000053)2.28169638
32Neoplasm of the oral cavity (HP:0100649)2.27733302
33Broad thumb (HP:0011304)2.24623194
34Ectopic kidney (HP:0000086)2.19245508
35High pitched voice (HP:0001620)2.18255290
36Hand muscle atrophy (HP:0009130)2.13932857
37Basal cell carcinoma (HP:0002671)2.13916450
38Gastrointestinal carcinoma (HP:0002672)2.13767943
39Malignant gastrointestinal tract tumors (HP:0006749)2.13767943
40Skull defect (HP:0001362)2.09842116
41Supernumerary ribs (HP:0005815)2.09435061
42Glioma (HP:0009733)2.08888828
43Ulnar bowing (HP:0003031)2.08809109
44Colon cancer (HP:0003003)2.06792199
45Rectal prolapse (HP:0002035)2.06454149
46Broad palm (HP:0001169)2.06262683
47Renovascular hypertension (HP:0100817)2.05441221
48Abnormality of the phalanges of the hallux (HP:0010057)2.04601206
49Protrusio acetabuli (HP:0003179)2.04577060
50Syringomyelia (HP:0003396)2.02896805
51Spinal cord lesions (HP:0100561)2.02896805
52Abnormal number of incisors (HP:0011064)2.01702201
53Flat acetabular roof (HP:0003180)2.01226120
54Upper limb amyotrophy (HP:0009129)2.00286276
55Distal upper limb amyotrophy (HP:0007149)2.00286276
56Skin tags (HP:0010609)1.98658036
57Asymmetry of the thorax (HP:0001555)1.98050658
58Ankyloglossia (HP:0010296)1.96795574
59Missing ribs (HP:0000921)1.96212258
60Elfin facies (HP:0004428)1.95523735
61Fragile skin (HP:0001030)1.92608656
62Narrow palate (HP:0000189)1.92494802
63Neoplasm of striated muscle (HP:0009728)1.92390158
64Atrophic scars (HP:0001075)1.92309513
65Distal lower limb amyotrophy (HP:0008944)1.91123211
66Vertebral fusion (HP:0002948)1.88942298
67Genu recurvatum (HP:0002816)1.87314481
68Overlapping toe (HP:0001845)1.86906478
69Bowel diverticulosis (HP:0005222)1.86225186
70Patellar dislocation (HP:0002999)1.86076883
71Mitral regurgitation (HP:0001653)1.86073546
72Deep palmar crease (HP:0006191)1.86014590
73Biconcave vertebral bodies (HP:0004586)1.85667646
74Broad phalanges of the hand (HP:0009768)1.85633619
75Rib fusion (HP:0000902)1.85189037
76Abnormality of oral frenula (HP:0000190)1.84485552
77Arnold-Chiari malformation (HP:0002308)1.83594455
78Cutis marmorata (HP:0000965)1.82763107
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82653948
80Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82424664
81Abnormality of the columella (HP:0009929)1.82397302
82Sparse lateral eyebrow (HP:0005338)1.81450017
83Anal stenosis (HP:0002025)1.80946068
84Achilles tendon contracture (HP:0001771)1.80876853
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.79649789
86Supernumerary bones of the axial skeleton (HP:0009144)1.79620315
87Aortic aneurysm (HP:0004942)1.79548134
88Thin ribs (HP:0000883)1.77538601
89Overriding aorta (HP:0002623)1.77223469
90Abnormality of the lower motor neuron (HP:0002366)1.77008918
91Advanced eruption of teeth (HP:0006288)1.76780897
92Short phalanx of the thumb (HP:0009660)1.76702136
93Segmental peripheral demyelination/remyelination (HP:0003481)1.75451188
94Wormian bones (HP:0002645)1.74625299
95Obsessive-compulsive behavior (HP:0000722)1.74240813
96Pointed chin (HP:0000307)1.74234779
97Vertebral arch anomaly (HP:0008438)1.73730508
98Dislocated radial head (HP:0003083)1.73432894
99Spina bifida occulta (HP:0003298)1.73416992
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.72200422
101Dilatation of the ascending aorta (HP:0005111)1.71970937
102Metaphyseal cupping (HP:0003021)1.71832454
103Truncal obesity (HP:0001956)1.71685381
104Bicuspid aortic valve (HP:0001647)1.71445988
105Insomnia (HP:0100785)1.71399515
106Limited elbow extension (HP:0001377)1.71211664
107Disproportionate tall stature (HP:0001519)1.70891884
108Vertebral compression fractures (HP:0002953)1.70840526
109Persistence of primary teeth (HP:0006335)1.70670032
110Low anterior hairline (HP:0000294)1.70134771
111Bronchomalacia (HP:0002780)1.70131614
112Increased connective tissue (HP:0009025)1.70016616
113Joint laxity (HP:0001388)1.68719069
114Lower limb amyotrophy (HP:0007210)1.68651305
115Mitral valve prolapse (HP:0001634)1.68559075
116Thin bony cortex (HP:0002753)1.68148679
117Neonatal short-limb short stature (HP:0008921)1.67679201
118Abnormality of the intervertebral disk (HP:0005108)1.67473099
119Facial hemangioma (HP:0000329)1.67392557
120Sandal gap (HP:0001852)1.67133816
121Cerebral inclusion bodies (HP:0100314)1.66987172
122Abnormality of the radial head (HP:0003995)1.66509875
123Biliary tract neoplasm (HP:0100574)1.66418476
124Broad distal phalanx of finger (HP:0009836)1.65873809
125Bladder diverticulum (HP:0000015)1.64967099
126Broad finger (HP:0001500)1.64819934
127Preauricular skin tag (HP:0000384)1.64519419
128Abnormality of the humeroradial joint (HP:0100744)1.64450158
129Abnormality of the calcaneus (HP:0008364)1.63505989
130Aneurysm (HP:0002617)1.62365230
131Precocious puberty (HP:0000826)1.61872335
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61097642
133Rhabdomyosarcoma (HP:0002859)1.60716326
134Deep philtrum (HP:0002002)1.60582549
135Patellar aplasia (HP:0006443)1.60256399
136Subacute progressive viral hepatitis (HP:0006572)1.60040816
137Abnormality of the thoracic spine (HP:0100711)1.59661075
138Natal tooth (HP:0000695)1.59488183
139Smooth philtrum (HP:0000319)1.59420844
140Cafe-au-lait spot (HP:0000957)1.59091842
141Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58850399
142Short 1st metacarpal (HP:0010034)1.58850399
143High anterior hairline (HP:0009890)1.58753996
144Hemivertebrae (HP:0002937)1.58373096
145Cellulitis (HP:0100658)1.58340700
146Hammertoe (HP:0001765)1.57581678
147Premature skin wrinkling (HP:0100678)1.56670549
148Slow saccadic eye movements (HP:0000514)1.56180231
149Arterial tortuosity (HP:0005116)1.55645001
150Germ cell neoplasia (HP:0100728)1.55636127
151Abnormality of the Achilles tendon (HP:0005109)1.55581031
152Turricephaly (HP:0000262)1.54426636
153Blue sclerae (HP:0000592)1.54398447
154Cervical subluxation (HP:0003308)1.53995286
155Bowel incontinence (HP:0002607)1.53781659
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.53654151
157Osteolytic defects of the hand bones (HP:0009699)1.53654151
158Hypercortisolism (HP:0001578)1.53351625
159Increased variability in muscle fiber diameter (HP:0003557)1.53198421
160Abnormality of the distal phalanges of the toes (HP:0010182)1.52272866
161Vascular tortuosity (HP:0004948)1.51143524
162Mild short stature (HP:0003502)1.50710755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.23035618
2EEF2K3.59982639
3MAP3K103.55620803
4PRPF4B3.29033278
5CDC73.19345954
6* CDK122.83442715
7TRIB32.67160765
8PKN22.62255530
9NEK22.52281328
10ICK2.19787577
11CAMK1D2.09051971
12STK102.07169108
13MAP4K11.89912825
14CAMK1G1.88519499
15CDK41.73612818
16TTN1.71016283
17* MTOR1.70474366
18ERN11.66380211
19RPS6KB21.61911792
20ALK1.59115686
21PTK61.56580959
22CDK61.55258115
23PASK1.53908998
24MAP3K131.53329551
25SCYL21.46207711
26PDGFRA1.41295711
27LATS11.40853735
28RIPK11.39623936
29TTK1.33734711
30MARK21.32314323
31ATR1.30454828
32PAK41.30407990
33CHEK11.27627373
34KSR21.27502679
35STK41.24374352
36BMX1.23866321
37MAP3K81.23579110
38SIK11.22397269
39EPHA21.19715482
40TSSK61.17626908
41LRRK21.12031929
42RPS6KA41.08214673
43STK31.08060535
44* CDK71.07957937
45WEE11.06867937
46NEK11.04529150
47SIK21.03749233
48SIK31.03649049
49RPS6KA21.03408244
50TYRO31.02598002
51GRK61.01526991
52MAP3K141.00779478
53NTRK10.99501884
54PAK20.95684399
55* CDK20.93509175
56ATM0.93415074
57PIM10.93322015
58FGFR10.93053261
59PLK10.90502605
60TGFBR10.90150120
61MELK0.89971170
62AURKB0.89458983
63WNK10.87351393
64TESK20.86970321
65PRKD20.86804631
66CHUK0.86604166
67MAP3K90.86204273
68MAPK110.85875907
69MAP2K30.82677175
70TAOK20.81304593
71IRAK30.81158599
72PDGFRB0.79667487
73FGFR40.78971936
74MAP2K20.77518985
75CHEK20.77330394
76MKNK10.76280425
77MAP3K10.76077935
78FGFR30.73886550
79PTK20.72296111
80SGK30.69498977
81RET0.66946814
82ITK0.65273425
83MARK30.64651783
84ZAP700.64590364
85MAPK100.64375886
86* CDK10.64249159
87FLT30.63830194
88PDPK10.62591465
89JAK30.62533459
90BTK0.62411211
91PNCK0.62402999
92CSNK1D0.62202621
93DMPK0.62059034
94RIPK40.59624979
95MOS0.59610181
96EPHB10.59285154
97MKNK20.59283300
98STK380.59155095
99LATS20.57222353
100RPS6KA60.55932526
101* MAPK10.55243387
102DDR20.55211733
103AKT20.54970952
104TAOK10.54747129
105ARAF0.53854278
106MAP3K30.52983544
107* MAPK140.52659597
108CLK10.51882855
109PRKD30.49635892
110HCK0.49116641
111* PRKDC0.48761494
112RPS6KA10.48602966
113CAMKK10.48518032
114CDC42BPA0.47349612
115DYRK30.46305868
116AKT10.46163057
117CSNK1E0.46019073
118MAP3K70.44573686
119PRKCH0.44424415
120* GSK3B0.43196378
121CSK0.42450376
122CSF1R0.42133444
123PDK10.41835663
124PLK30.41282946
125BRAF0.38405974
126EGFR0.37813881
127UHMK10.37776951
128DYRK1B0.37248205
129RPS6KL10.37224640
130RPS6KC10.37224640
131MAPK80.36013197
132FGFR20.35425619
133BUB10.35300572
134HIPK20.34969275
135JAK10.34325898
136MAPK70.34130074
137CDK11A0.33702653
138KSR10.33691815
139MAPK90.33467585
140CAMK40.33323618

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.48039060
2RNA transport_Homo sapiens_hsa030132.30471323
3Cell cycle_Homo sapiens_hsa041102.26488131
4Spliceosome_Homo sapiens_hsa030402.22288184
5Mismatch repair_Homo sapiens_hsa034302.10841917
6mRNA surveillance pathway_Homo sapiens_hsa030152.09435539
7Lysine degradation_Homo sapiens_hsa003101.89813988
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84271442
9Notch signaling pathway_Homo sapiens_hsa043301.83304164
10Chronic myeloid leukemia_Homo sapiens_hsa052201.80923129
11Base excision repair_Homo sapiens_hsa034101.76495694
12One carbon pool by folate_Homo sapiens_hsa006701.70302121
13Adherens junction_Homo sapiens_hsa045201.70059026
14MicroRNAs in cancer_Homo sapiens_hsa052061.66776228
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66564557
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62660684
17Small cell lung cancer_Homo sapiens_hsa052221.57655739
18Basal cell carcinoma_Homo sapiens_hsa052171.48691576
19HTLV-I infection_Homo sapiens_hsa051661.43615339
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41315265
21Antigen processing and presentation_Homo sapiens_hsa046121.38882346
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38695059
23Viral carcinogenesis_Homo sapiens_hsa052031.38459613
24mTOR signaling pathway_Homo sapiens_hsa041501.37457739
25p53 signaling pathway_Homo sapiens_hsa041151.34463547
26ErbB signaling pathway_Homo sapiens_hsa040121.34277366
27Colorectal cancer_Homo sapiens_hsa052101.33297266
28Non-homologous end-joining_Homo sapiens_hsa034501.31385523
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30403992
30Hippo signaling pathway_Homo sapiens_hsa043901.27874338
31Proteoglycans in cancer_Homo sapiens_hsa052051.26998994
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26866764
33Viral myocarditis_Homo sapiens_hsa054161.26230761
34Acute myeloid leukemia_Homo sapiens_hsa052211.23864336
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22150377
36Nucleotide excision repair_Homo sapiens_hsa034201.21306777
37B cell receptor signaling pathway_Homo sapiens_hsa046621.21205678
38Other glycan degradation_Homo sapiens_hsa005111.19676390
39Non-small cell lung cancer_Homo sapiens_hsa052231.16900228
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16806844
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12708852
42* Herpes simplex infection_Homo sapiens_hsa051681.11688499
43Endometrial cancer_Homo sapiens_hsa052131.11218575
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10983251
45Prion diseases_Homo sapiens_hsa050201.10420392
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10072708
47Thyroid cancer_Homo sapiens_hsa052161.09083540
48Pancreatic cancer_Homo sapiens_hsa052121.08146007
49Homologous recombination_Homo sapiens_hsa034401.07799146
50Primary immunodeficiency_Homo sapiens_hsa053401.07401049
51Fanconi anemia pathway_Homo sapiens_hsa034601.06278517
52Long-term potentiation_Homo sapiens_hsa047201.05801693
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05613621
54Inositol phosphate metabolism_Homo sapiens_hsa005621.05341698
55RNA degradation_Homo sapiens_hsa030181.04903169
56Choline metabolism in cancer_Homo sapiens_hsa052311.04864545
57Prostate cancer_Homo sapiens_hsa052151.03833541
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.03279495
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.02877386
60Hepatitis B_Homo sapiens_hsa051611.02430302
61Dorso-ventral axis formation_Homo sapiens_hsa043201.02211198
62Estrogen signaling pathway_Homo sapiens_hsa049151.01043402
63Focal adhesion_Homo sapiens_hsa045101.00915780
64TGF-beta signaling pathway_Homo sapiens_hsa043501.00523322
65* Epstein-Barr virus infection_Homo sapiens_hsa051691.00356165
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.98847834
67Bladder cancer_Homo sapiens_hsa052190.98540439
68Hedgehog signaling pathway_Homo sapiens_hsa043400.97801326
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.97528786
70T cell receptor signaling pathway_Homo sapiens_hsa046600.96733713
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96603808
72Apoptosis_Homo sapiens_hsa042100.95811674
73Pathways in cancer_Homo sapiens_hsa052000.93972382
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.92032109
75GnRH signaling pathway_Homo sapiens_hsa049120.91224924
76Toxoplasmosis_Homo sapiens_hsa051450.90878861
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90129638
78Hepatitis C_Homo sapiens_hsa051600.90101751
79Renal cell carcinoma_Homo sapiens_hsa052110.82256798
80Shigellosis_Homo sapiens_hsa051310.80358535
81Oocyte meiosis_Homo sapiens_hsa041140.80143244
82Osteoclast differentiation_Homo sapiens_hsa043800.80045518
83Melanogenesis_Homo sapiens_hsa049160.79544617
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78561119
85ECM-receptor interaction_Homo sapiens_hsa045120.76683574
86Glioma_Homo sapiens_hsa052140.75750173
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75551046
88Type II diabetes mellitus_Homo sapiens_hsa049300.75389580
89FoxO signaling pathway_Homo sapiens_hsa040680.75375925
90VEGF signaling pathway_Homo sapiens_hsa043700.75162132
91Measles_Homo sapiens_hsa051620.74970736
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74845588
93HIF-1 signaling pathway_Homo sapiens_hsa040660.74289526
94Leishmaniasis_Homo sapiens_hsa051400.74261766
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.73891961
96Wnt signaling pathway_Homo sapiens_hsa043100.72475463
97Insulin resistance_Homo sapiens_hsa049310.71976184
98Influenza A_Homo sapiens_hsa051640.70898147
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70509230
100Pentose phosphate pathway_Homo sapiens_hsa000300.70472173
101Endocytosis_Homo sapiens_hsa041440.70399296
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68865686
103Tight junction_Homo sapiens_hsa045300.67124351
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66334583
105Basal transcription factors_Homo sapiens_hsa030220.66207317
106MAPK signaling pathway_Homo sapiens_hsa040100.65885827
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65476232
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64933662
109Selenocompound metabolism_Homo sapiens_hsa004500.64073285
110Amoebiasis_Homo sapiens_hsa051460.62409657
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62398087
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61685241
113AMPK signaling pathway_Homo sapiens_hsa041520.61063753
114Prolactin signaling pathway_Homo sapiens_hsa049170.60081240
115Melanoma_Homo sapiens_hsa052180.59548732
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.58489501
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.58412305
118Platelet activation_Homo sapiens_hsa046110.58268028
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55879202
120Axon guidance_Homo sapiens_hsa043600.55487719
121TNF signaling pathway_Homo sapiens_hsa046680.55212702
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54222702
123Gap junction_Homo sapiens_hsa045400.52857050
124Systemic lupus erythematosus_Homo sapiens_hsa053220.52701641
125Chemokine signaling pathway_Homo sapiens_hsa040620.52432871
126Hematopoietic cell lineage_Homo sapiens_hsa046400.51577667
127Insulin signaling pathway_Homo sapiens_hsa049100.50774045
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50666816
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48543113
130Rap1 signaling pathway_Homo sapiens_hsa040150.46828445
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45894616

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