POLI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.88573127
2epithelial cilium movement (GO:0003351)5.04259613
3ribosomal small subunit assembly (GO:0000028)5.00929331
4cilium movement (GO:0003341)4.61162121
5intraciliary transport (GO:0042073)4.60110007
6DNA deamination (GO:0045006)4.59698937
7nonmotile primary cilium assembly (GO:0035058)4.26357375
8telomere maintenance via semi-conservative replication (GO:0032201)4.21609032
9DNA replication initiation (GO:0006270)4.18781734
10DNA strand elongation involved in DNA replication (GO:0006271)4.12418781
11cilium or flagellum-dependent cell motility (GO:0001539)4.03178527
12DNA strand elongation (GO:0022616)3.99813137
13neural tube formation (GO:0001841)3.93968526
14presynaptic membrane assembly (GO:0097105)3.92671124
15telomere maintenance via recombination (GO:0000722)3.87069896
16regulation of cilium movement (GO:0003352)3.85199249
17cilium morphogenesis (GO:0060271)3.76685978
18pyrimidine nucleobase catabolic process (GO:0006208)3.71472614
19chromatin remodeling at centromere (GO:0031055)3.68720974
20CENP-A containing nucleosome assembly (GO:0034080)3.68337129
21maturation of SSU-rRNA (GO:0030490)3.66920275
22telomere maintenance via telomere lengthening (GO:0010833)3.65507745
23DNA replication checkpoint (GO:0000076)3.60946119
24cilium organization (GO:0044782)3.59356062
25mitotic recombination (GO:0006312)3.59315791
26DNA double-strand break processing (GO:0000729)3.58284180
27meiotic chromosome segregation (GO:0045132)3.57384064
28cilium assembly (GO:0042384)3.56861074
29kinetochore organization (GO:0051383)3.51726929
30DNA unwinding involved in DNA replication (GO:0006268)3.51595294
31axoneme assembly (GO:0035082)3.49499348
32IMP biosynthetic process (GO:0006188)3.48722332
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.43296149
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43296149
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.39743989
36axonemal dynein complex assembly (GO:0070286)3.39086084
37IMP metabolic process (GO:0046040)3.36292199
38presynaptic membrane organization (GO:0097090)3.34212504
39kidney morphogenesis (GO:0060993)3.32627663
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.32304284
41limb bud formation (GO:0060174)3.30505364
42intra-S DNA damage checkpoint (GO:0031573)3.28255226
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.27417457
44telomere maintenance (GO:0000723)3.24444011
45protein localization to kinetochore (GO:0034501)3.22717963
46telomere organization (GO:0032200)3.22441045
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22174293
48negative regulation of translation, ncRNA-mediated (GO:0040033)3.22174293
49regulation of translation, ncRNA-mediated (GO:0045974)3.22174293
50mismatch repair (GO:0006298)3.21963251
51DNA replication-independent nucleosome organization (GO:0034724)3.20272436
52DNA replication-independent nucleosome assembly (GO:0006336)3.20272436
53olfactory bulb development (GO:0021772)3.18591451
54kinetochore assembly (GO:0051382)3.18008961
55photoreceptor cell maintenance (GO:0045494)3.17827236
56histone H2A acetylation (GO:0043968)3.17327706
57centriole replication (GO:0007099)3.17115310
58protein localization to cilium (GO:0061512)3.16715266
59somite development (GO:0061053)3.15481288
60protein localization to chromosome, centromeric region (GO:0071459)3.13279822
61histone exchange (GO:0043486)3.09294585
62regulation of mesoderm development (GO:2000380)3.07598126
63nucleobase biosynthetic process (GO:0046112)3.06591483
64replication fork processing (GO:0031297)3.06097748
65viral mRNA export from host cell nucleus (GO:0046784)3.05266487
66attachment of spindle microtubules to kinetochore (GO:0008608)3.01607787
67ribosomal small subunit biogenesis (GO:0042274)3.00639087
68dorsal/ventral axis specification (GO:0009950)2.99792275
69translesion synthesis (GO:0019985)2.99480450
70translational termination (GO:0006415)2.99213211
71viral transcription (GO:0019083)2.99209386
72regulation of development, heterochronic (GO:0040034)2.98487073
73regulation of helicase activity (GO:0051095)2.98221022
74formation of translation preinitiation complex (GO:0001731)2.98196282
75ribosome biogenesis (GO:0042254)2.97632860
76protein K6-linked ubiquitination (GO:0085020)2.96355312
77appendage development (GO:0048736)2.93839917
78limb development (GO:0060173)2.93839917
79pseudouridine synthesis (GO:0001522)2.93807076
80tRNA methylation (GO:0030488)2.93706650
81ribonucleoprotein complex biogenesis (GO:0022613)2.93232044
82nuclear pore complex assembly (GO:0051292)2.92055765
83maturation of 5.8S rRNA (GO:0000460)2.91341926
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90923277
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90923277
86isotype switching (GO:0045190)2.90923277
87regulation of histone H3-K9 methylation (GO:0051570)2.90747056
88regulation of meiosis I (GO:0060631)2.88182514
89purine nucleobase biosynthetic process (GO:0009113)2.87785522
90DNA duplex unwinding (GO:0032508)2.87703806
91retinal ganglion cell axon guidance (GO:0031290)2.87101537
92nuclear pore organization (GO:0006999)2.87050894
93protein polyglutamylation (GO:0018095)2.86643513
94DNA geometric change (GO:0032392)2.86276046
95resolution of meiotic recombination intermediates (GO:0000712)2.84723141
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.83625157
97response to pheromone (GO:0019236)2.83047139
98synapsis (GO:0007129)2.82849924
99mitotic metaphase plate congression (GO:0007080)2.82735288
100regulation of non-canonical Wnt signaling pathway (GO:2000050)2.82604765
101cellular component assembly involved in morphogenesis (GO:0010927)2.82397541
102metaphase plate congression (GO:0051310)2.81786867
103postreplication repair (GO:0006301)2.80969044
104nucleobase catabolic process (GO:0046113)2.80805104
105regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.80698091
106proteasome assembly (GO:0043248)2.80559565
107calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78841514
108ribosomal large subunit biogenesis (GO:0042273)2.78701677
109regulation of timing of cell differentiation (GO:0048505)2.76992547
110DNA integration (GO:0015074)2.76887478
111rRNA processing (GO:0006364)2.76407793
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76004692
113positive regulation of oligodendrocyte differentiation (GO:0048714)2.75537678
114mitotic sister chromatid segregation (GO:0000070)2.74234928
115establishment of chromosome localization (GO:0051303)2.73877712
116mitotic nuclear envelope disassembly (GO:0007077)2.73771393
117regulation of growth hormone secretion (GO:0060123)2.73540074
118spliceosomal snRNP assembly (GO:0000387)2.73004661
119translational elongation (GO:0006414)2.72475675
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72199349
121somatic recombination of immunoglobulin gene segments (GO:0016447)2.71638712
122postsynaptic membrane organization (GO:0001941)2.71550343
123DNA synthesis involved in DNA repair (GO:0000731)2.71167531
124smoothened signaling pathway (GO:0007224)2.71084807
125establishment of integrated proviral latency (GO:0075713)2.70984579
126reciprocal meiotic recombination (GO:0007131)2.70134518
127reciprocal DNA recombination (GO:0035825)2.70134518
128rRNA metabolic process (GO:0016072)2.70010183
129retinal rod cell development (GO:0046548)2.69672153
130transcription-coupled nucleotide-excision repair (GO:0006283)2.69450791
131microtubule anchoring (GO:0034453)2.68934778
132acrosome assembly (GO:0001675)2.67635758
133termination of RNA polymerase II transcription (GO:0006369)2.67559323
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65229086
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64716696
136histone mRNA metabolic process (GO:0008334)2.64434994
137DNA replication-dependent nucleosome assembly (GO:0006335)2.63327144
138DNA replication-dependent nucleosome organization (GO:0034723)2.63327144
139definitive hemopoiesis (GO:0060216)2.63326877
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.63156369
141somite rostral/caudal axis specification (GO:0032525)2.62684589
142forebrain morphogenesis (GO:0048853)2.62124096
143negative regulation of DNA recombination (GO:0045910)2.62038837
144telomere maintenance via telomerase (GO:0007004)2.62016463
145regulation of mitotic spindle checkpoint (GO:1903504)2.61222259
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61222259
147base-excision repair (GO:0006284)2.61038599
148* DNA replication (GO:0006260)2.60644758
149nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60234651
150nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59784580
151snRNA processing (GO:0016180)2.59547711
152somatic diversification of immunoglobulins (GO:0016445)2.59008569
153RNA-dependent DNA replication (GO:0006278)2.57636711
154genitalia morphogenesis (GO:0035112)2.57327325
155dosage compensation (GO:0007549)2.57071371
156neuron fate determination (GO:0048664)2.57008823
157DNA conformation change (GO:0071103)2.55270220
158positive regulation of growth hormone secretion (GO:0060124)2.51591661
159branched-chain amino acid catabolic process (GO:0009083)2.50911567
160single strand break repair (GO:0000012)2.50443738
161regulation of hexokinase activity (GO:1903299)2.49136096
162regulation of glucokinase activity (GO:0033131)2.49136096
163otic vesicle formation (GO:0030916)2.48956571
164prenylation (GO:0097354)2.48887855
165protein prenylation (GO:0018342)2.48887855
166spermatid nucleus differentiation (GO:0007289)2.46545256
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.46270074
168ventricular system development (GO:0021591)2.45643048
169determination of left/right symmetry (GO:0007368)2.45263771
170determination of bilateral symmetry (GO:0009855)2.44848335
171retinal cone cell development (GO:0046549)2.44754551
172microtubule depolymerization (GO:0007019)2.43803939
173photoreceptor cell development (GO:0042461)2.43417088
174forebrain neuron differentiation (GO:0021879)2.41998334
175regulation of oligodendrocyte differentiation (GO:0048713)2.38509569
176regulation of telomere maintenance (GO:0032204)2.38114476
177specification of symmetry (GO:0009799)2.37428298
178neuron cell-cell adhesion (GO:0007158)2.36754672
179regulation of collateral sprouting (GO:0048670)2.35537184
180eye photoreceptor cell development (GO:0042462)2.35041660
181embryonic epithelial tube formation (GO:0001838)2.34828982
182L-fucose catabolic process (GO:0042355)2.34571180
183fucose catabolic process (GO:0019317)2.34571180
184L-fucose metabolic process (GO:0042354)2.34571180
185pancreas development (GO:0031016)2.34485630
186mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33803872
187positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33803872
188central nervous system neuron axonogenesis (GO:0021955)2.33250407
189recombinational repair (GO:0000725)2.32809953
190double-strand break repair via homologous recombination (GO:0000724)2.32095312
191DNA ligation (GO:0006266)2.31896453
192dorsal/ventral pattern formation (GO:0009953)2.28764915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18980156
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71335279
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.70656484
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.12916569
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.03794599
6ZNF274_21170338_ChIP-Seq_K562_Hela3.03467688
7GBX2_23144817_ChIP-Seq_PC3_Human2.97967891
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93577996
9IGF1R_20145208_ChIP-Seq_DFB_Human2.93223795
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83075804
11FUS_26573619_Chip-Seq_HEK293_Human2.80641124
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.73658406
13TAF15_26573619_Chip-Seq_HEK293_Human2.72437890
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68410027
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68247708
16EWS_26573619_Chip-Seq_HEK293_Human2.64072734
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62117258
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61329675
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57192754
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50098976
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49625961
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48664056
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46155448
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43844584
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.43170986
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34733020
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30827660
28* P300_19829295_ChIP-Seq_ESCs_Human2.28760909
29VDR_23849224_ChIP-Seq_CD4+_Human2.28063046
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.26114728
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24477533
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21977952
33FOXP3_21729870_ChIP-Seq_TREG_Human2.18536964
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17832512
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.14362991
36PIAS1_25552417_ChIP-Seq_VCAP_Human2.11362247
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11111790
38VDR_22108803_ChIP-Seq_LS180_Human2.10285193
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08339987
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07733157
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04674975
42FLI1_27457419_Chip-Seq_LIVER_Mouse2.03742945
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00825850
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99281839
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96986247
46XRN2_22483619_ChIP-Seq_HELA_Human1.95388353
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91470723
48* E2F1_21310950_ChIP-Seq_MCF-7_Human1.90687140
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89978421
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88606192
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87770202
52CIITA_25753668_ChIP-Seq_RAJI_Human1.87035530
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86782246
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85399860
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85308169
56EZH2_22144423_ChIP-Seq_EOC_Human1.84947215
57SCL_19346495_ChIP-Seq_HPC-7_Human1.84910422
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.80669541
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79162349
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78756354
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78643558
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.78024410
63SMAD4_21799915_ChIP-Seq_A2780_Human1.77992315
64ELK1_19687146_ChIP-ChIP_HELA_Human1.74184289
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74114430
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73556500
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73102389
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71332529
69MYC_22102868_ChIP-Seq_BL_Human1.69746579
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68921209
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68410409
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67715054
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67436852
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67073063
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66636767
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65289005
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65095771
78TTF2_22483619_ChIP-Seq_HELA_Human1.64837172
79* GABP_19822575_ChIP-Seq_HepG2_Human1.63445468
80* SRF_21415370_ChIP-Seq_HL-1_Mouse1.62933067
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62091960
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60987558
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.59365619
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59180798
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57603639
86* STAT3_23295773_ChIP-Seq_U87_Human1.56598484
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55604125
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54594816
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52040210
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51260171
91DCP1A_22483619_ChIP-Seq_HELA_Human1.49818129
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48113248
93ER_23166858_ChIP-Seq_MCF-7_Human1.45778861
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.44383082
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.44248564
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.42093217
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41927994
98BCAT_22108803_ChIP-Seq_LS180_Human1.41059083
99CBP_20019798_ChIP-Seq_JUKART_Human1.41039040
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41039040
101* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40501054
102AR_25329375_ChIP-Seq_VCAP_Human1.39639004
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39470568
104RNF2_27304074_Chip-Seq_NSC_Mouse1.38817498
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.38487013
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37998468
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37385935
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.36865105
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36000720
110TCF4_23295773_ChIP-Seq_U87_Human1.35718219
111RUNX2_22187159_ChIP-Seq_PCA_Human1.35455640
112SPI1_23547873_ChIP-Seq_NB4_Human1.33713952
113TCF4_22108803_ChIP-Seq_LS180_Human1.32546608
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31973925
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31973925
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31859028
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31663977
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29906119
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28368552
120* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28303295
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27203573
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27014727
123KDM5A_27292631_Chip-Seq_BREAST_Human1.25181834
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24741454
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23903065
126AR_21909140_ChIP-Seq_LNCAP_Human1.23786475
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21460947
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.20193653
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.18270857
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16464990
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.16219863
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14619469
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.14359724
134P53_22387025_ChIP-Seq_ESCs_Mouse1.12713602
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12653712
136* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12156634
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11477345
138TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10908537
139* SOX2_19829295_ChIP-Seq_ESCs_Human1.10438671
140* NANOG_19829295_ChIP-Seq_ESCs_Human1.10438671
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09631418
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09384284
143* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07385711
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07299160
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06802812
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.06167823
147SOX2_16153702_ChIP-ChIP_HESCs_Human1.05968822
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.04995511
149SMAD4_21741376_ChIP-Seq_EPCs_Human1.03990876
150FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03925459
151MYB_26560356_Chip-Seq_TH1_Human1.03659388
152SOX2_21211035_ChIP-Seq_LN229_Gbm1.02541191
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02527588
154STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01952754
155* MYB_26560356_Chip-Seq_TH2_Human1.01089718
156SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00573043
157WT1_19549856_ChIP-ChIP_CCG9911_Human1.00230712
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00145231
159NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00145231
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00136310
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99824893
162MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99558020
163NANOG_16153702_ChIP-ChIP_HESCs_Human0.99185001
164* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98931030
165CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98783297
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.98332843
167* MYC_18940864_ChIP-ChIP_HL60_Human0.98325333
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97040449
169VDR_21846776_ChIP-Seq_THP-1_Human0.96634199
170GATA1_22025678_ChIP-Seq_K562_Human0.95596727
171TFEB_21752829_ChIP-Seq_HELA_Human0.94738185
172IRF8_21731497_ChIP-ChIP_J774_Mouse0.94692901
173IRF1_19129219_ChIP-ChIP_H3396_Human0.93244877
174CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92989203
175CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90781380
176SALL1_21062744_ChIP-ChIP_HESCs_Human0.90404540
177STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89558204
178* RUNX1_22412390_ChIP-Seq_EML_Mouse0.89244249
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87011992
180* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86877013
181SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80244497
182GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78860050
183* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78068027
184KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77990873
185LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77912759
186CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77222749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.42509467
2MP0003693_abnormal_embryo_hatching4.07962136
3MP0008058_abnormal_DNA_repair3.82206195
4MP0008057_abnormal_DNA_replication3.74647548
5MP0003111_abnormal_nucleus_morphology3.35456574
6MP0002396_abnormal_hematopoietic_system3.28447639
7MP0003077_abnormal_cell_cycle3.15907725
8MP0008877_abnormal_DNA_methylation3.02871962
9MP0004957_abnormal_blastocyst_morpholog2.94386374
10MP0008007_abnormal_cellular_replicative2.72399349
11MP0002653_abnormal_ependyma_morphology2.69941638
12MP0003763_abnormal_thymus_physiology2.64517140
13MP0003122_maternal_imprinting2.52757723
14MP0003880_abnormal_central_pattern2.40322647
15MP0001835_abnormal_antigen_presentation2.37262766
16MP0006292_abnormal_olfactory_placode2.34728073
17MP0002102_abnormal_ear_morphology2.33940274
18MP0001984_abnormal_olfaction2.24672953
19MP0004808_abnormal_hematopoietic_stem2.24311909
20MP0004133_heterotaxia2.21217664
21MP0003136_yellow_coat_color2.14224546
22MP0005075_abnormal_melanosome_morpholog2.09036767
23MP0002398_abnormal_bone_marrow2.00741957
24MP0003937_abnormal_limbs/digits/tail_de1.99614808
25MP0003786_premature_aging1.98451578
26MP0000778_abnormal_nervous_system1.96476107
27MP0008789_abnormal_olfactory_epithelium1.95556316
28MP0006072_abnormal_retinal_apoptosis1.95510918
29MP0000685_abnormal_immune_system1.93963778
30MP0005671_abnormal_response_to1.87438741
31MP0000490_abnormal_crypts_of1.85677893
32MP0005174_abnormal_tail_pigmentation1.81690292
33MP0001545_abnormal_hematopoietic_system1.80571888
34MP0005397_hematopoietic_system_phenotyp1.80571888
35MP0005394_taste/olfaction_phenotype1.80132556
36MP0005499_abnormal_olfactory_system1.80132556
37MP0001529_abnormal_vocalization1.79698326
38MP0005253_abnormal_eye_physiology1.79011809
39MP0005248_abnormal_Harderian_gland1.77242760
40MP0001800_abnormal_humoral_immune1.76332073
41MP0002638_abnormal_pupillary_reflex1.74604804
42MP0000703_abnormal_thymus_morphology1.73105262
43MP0010307_abnormal_tumor_latency1.72097193
44MP0000383_abnormal_hair_follicle1.67763421
45MP0000689_abnormal_spleen_morphology1.66624141
46MP0006276_abnormal_autonomic_nervous1.65154298
47MP0002722_abnormal_immune_system1.64784207
48MP0002233_abnormal_nose_morphology1.63264867
49MP0002210_abnormal_sex_determination1.62840104
50MP0003283_abnormal_digestive_organ1.59463666
51MP0002938_white_spotting1.57683143
52MP0001929_abnormal_gametogenesis1.56683082
53MP0010030_abnormal_orbit_morphology1.56377629
54MP0002420_abnormal_adaptive_immunity1.55805330
55MP0000716_abnormal_immune_system1.55684263
56MP0001486_abnormal_startle_reflex1.55523714
57MP0000313_abnormal_cell_death1.54315991
58MP0003195_calcinosis1.53851254
59MP0000631_abnormal_neuroendocrine_gland1.53418913
60MP0001819_abnormal_immune_cell1.52931792
61MP0002019_abnormal_tumor_incidence1.51488103
62MP0002751_abnormal_autonomic_nervous1.50746196
63MP0005551_abnormal_eye_electrophysiolog1.49874783
64MP0009697_abnormal_copulation1.49649324
65MP0008932_abnormal_embryonic_tissue1.49649039
66MP0001485_abnormal_pinna_reflex1.49234386
67MP0002429_abnormal_blood_cell1.48844603
68MP0009333_abnormal_splenocyte_physiolog1.48622976
69MP0002723_abnormal_immune_serum1.48491027
70MP0002452_abnormal_antigen_presenting1.47847195
71MP0005377_hearing/vestibular/ear_phenot1.44548881
72MP0003878_abnormal_ear_physiology1.44548881
73MP0000350_abnormal_cell_proliferation1.44487732
74MP0003787_abnormal_imprinting1.40159881
75MP0001145_abnormal_male_reproductive1.38427091
76MP0003567_abnormal_fetal_cardiomyocyte1.38115159
77MP0002095_abnormal_skin_pigmentation1.36537496
78MP0001177_atelectasis1.36491562
79MP0003119_abnormal_digestive_system1.35729740
80MP0000015_abnormal_ear_pigmentation1.32858694
81MP0000427_abnormal_hair_cycle1.32167975
82MP0001986_abnormal_taste_sensitivity1.30248313
83MP0009785_altered_susceptibility_to1.29294276
84MP0001286_abnormal_eye_development1.28706066
85MP0010678_abnormal_skin_adnexa1.27249264
86MP0005025_abnormal_response_to1.26440103
87MP0002009_preneoplasia1.26259881
88MP0004043_abnormal_pH_regulation1.25920367
89MP0005000_abnormal_immune_tolerance1.25820856
90MP0000653_abnormal_sex_gland1.25754838
91MP0004142_abnormal_muscle_tone1.25624063
92MP0002282_abnormal_trachea_morphology1.25585858
93MP0004215_abnormal_myocardial_fiber1.23887108
94MP0003123_paternal_imprinting1.23808520
95MP0003718_maternal_effect1.23412312
96MP0001873_stomach_inflammation1.23386835
97MP0003755_abnormal_palate_morphology1.21381343
98MP0000049_abnormal_middle_ear1.20774830
99MP0001730_embryonic_growth_arrest1.19997884
100MP0001119_abnormal_female_reproductive1.18973469
101MP0005391_vision/eye_phenotype1.18769137
102MP0005464_abnormal_platelet_physiology1.18633977
103MP0005387_immune_system_phenotype1.18408076
104MP0001790_abnormal_immune_system1.18408076
105MP0008995_early_reproductive_senescence1.18141034
106MP0010352_gastrointestinal_tract_polyps1.16630133
107MP0002234_abnormal_pharynx_morphology1.16196932
108MP0001293_anophthalmia1.15411228
109MP0001188_hyperpigmentation1.14018278
110MP0003698_abnormal_male_reproductive1.13133480
111MP0005410_abnormal_fertilization1.11882125
112MP0003121_genomic_imprinting1.10443045
113MP0009703_decreased_birth_body1.10085504
114MP0002405_respiratory_system_inflammati1.07925453
115MP0003436_decreased_susceptibility_to1.06836746
116MP0003861_abnormal_nervous_system1.06781949
117MP0001299_abnormal_eye_distance/1.05959243
118MP0000858_altered_metastatic_potential1.05481667
119MP0001853_heart_inflammation1.05163151
120MP0000428_abnormal_craniofacial_morphol1.04411295
121MP0002148_abnormal_hypersensitivity_rea1.04017076
122MP0003137_abnormal_impulse_conducting1.03561140
123MP0000955_abnormal_spinal_cord1.00674452
124MP0002557_abnormal_social/conspecific_i1.00089186
125MP0000647_abnormal_sebaceous_gland0.98840091
126MP0002822_catalepsy0.98754497
127MP0002736_abnormal_nociception_after0.98650716
128MP0002752_abnormal_somatic_nervous0.97762438
129MP0002928_abnormal_bile_duct0.97627885
130MP0002006_tumorigenesis0.97307109
131MP0003938_abnormal_ear_development0.96972017
132MP0002090_abnormal_vision0.96246112
133MP0001697_abnormal_embryo_size0.96237349
134MP0002419_abnormal_innate_immunity0.95685581
135MP0005195_abnormal_posterior_eye0.95256122
136MP0010155_abnormal_intestine_physiology0.94843761
137MP0002184_abnormal_innervation0.94194578
138MP0000465_gastrointestinal_hemorrhage0.92650900
139MP0002132_abnormal_respiratory_system0.91326834
140MP0001919_abnormal_reproductive_system0.91223776
141MP0002080_prenatal_lethality0.91141100
142MP0002697_abnormal_eye_size0.90815014
143MP0003941_abnormal_skin_development0.90560108
144MP0005389_reproductive_system_phenotype0.90357651
145MP0003011_delayed_dark_adaptation0.90343798
146MP0005380_embryogenesis_phenotype0.90149070
147MP0001672_abnormal_embryogenesis/_devel0.90149070
148MP0002160_abnormal_reproductive_system0.89020904
149MP0009046_muscle_twitch0.88559333
150MP0002111_abnormal_tail_morphology0.88438098
151MP0002166_altered_tumor_susceptibility0.88292816
152MP0001324_abnormal_eye_pigmentation0.87149291
153MP0002084_abnormal_developmental_patter0.86965608
154MP0000026_abnormal_inner_ear0.84896397
155MP0002152_abnormal_brain_morphology0.84205956
156MP0003186_abnormal_redox_activity0.83953382
157MP0002116_abnormal_craniofacial_bone0.82725958
158MP0003935_abnormal_craniofacial_develop0.82719115
159MP0000516_abnormal_urinary_system0.81334228
160MP0005367_renal/urinary_system_phenotyp0.81334228
161MP0003890_abnormal_embryonic-extraembry0.81079835
162MP0001764_abnormal_homeostasis0.81062996
163MP0004885_abnormal_endolymph0.79969078
164MP0003806_abnormal_nucleotide_metabolis0.79416134
165MP0004147_increased_porphyrin_level0.77853722
166MP0001845_abnormal_inflammatory_respons0.77553954
167MP0004924_abnormal_behavior0.77344240
168MP0005386_behavior/neurological_phenoty0.77344240
169MP0002086_abnormal_extraembryonic_tissu0.76353399
170MP0003984_embryonic_growth_retardation0.75213141
171MP0006054_spinal_hemorrhage0.71883930
172MP0002088_abnormal_embryonic_growth/wei0.71035535
173MP0002075_abnormal_coat/hair_pigmentati0.69541891
174MP0002161_abnormal_fertility/fecundity0.69530866
175MP0002085_abnormal_embryonic_tissue0.69340954
176MP0003866_abnormal_defecation0.68337603
177MP0009278_abnormal_bone_marrow0.67878286
178MP0003943_abnormal_hepatobiliary_system0.66859354
179MP0000569_abnormal_digit_pigmentation0.65260889

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.54513971
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22616107
3Birth length less than 3rd percentile (HP:0003561)4.03799974
4Aplastic anemia (HP:0001915)3.95685044
5True hermaphroditism (HP:0010459)3.84147569
6Pancreatic cysts (HP:0001737)3.76525614
7Abnormality of chromosome stability (HP:0003220)3.72421866
8Medial flaring of the eyebrow (HP:0010747)3.67588769
9Congenital primary aphakia (HP:0007707)3.57270886
10Gait imbalance (HP:0002141)3.53796177
11Reticulocytopenia (HP:0001896)3.43827417
12Intestinal atresia (HP:0011100)3.41222242
13Agnosia (HP:0010524)3.41093847
14Nephrogenic diabetes insipidus (HP:0009806)3.40628595
15Nephronophthisis (HP:0000090)3.32050347
16Genital tract atresia (HP:0001827)3.27774770
17Abnormality of the preputium (HP:0100587)3.25009087
18Myelodysplasia (HP:0002863)3.23978150
19Vaginal atresia (HP:0000148)3.23349928
20IgM deficiency (HP:0002850)3.07678543
21Thrombocytosis (HP:0001894)3.07480528
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.04725290
23Abnormality of the labia minora (HP:0012880)3.03152482
24Medulloblastoma (HP:0002885)3.02834588
25Meckel diverticulum (HP:0002245)2.99709348
26Abnormality of the renal medulla (HP:0100957)2.94984212
27Abnormal ciliary motility (HP:0012262)2.91962237
28Abnormal number of erythroid precursors (HP:0012131)2.91741548
29Abnormality of the ileum (HP:0001549)2.90225148
30Abnormality of cells of the erythroid lineage (HP:0012130)2.86426437
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.82369039
32Abnormality of the anterior horn cell (HP:0006802)2.80652489
33Degeneration of anterior horn cells (HP:0002398)2.80652489
34Clubbing of toes (HP:0100760)2.79965464
35Abnormality of DNA repair (HP:0003254)2.76824830
36Abnormal biliary tract physiology (HP:0012439)2.76618684
37Bile duct proliferation (HP:0001408)2.76618684
38Colon cancer (HP:0003003)2.74236609
39Poor coordination (HP:0002370)2.73120592
40Chronic hepatic failure (HP:0100626)2.71105451
41Bone marrow hypocellularity (HP:0005528)2.70033936
42Oral leukoplakia (HP:0002745)2.69192891
43Abnormal respiratory motile cilium physiology (HP:0012261)2.64037671
44Postaxial foot polydactyly (HP:0001830)2.63806634
45Type 2 muscle fiber atrophy (HP:0003554)2.63496240
46Ependymoma (HP:0002888)2.58309366
47Broad foot (HP:0001769)2.58009140
48Type I transferrin isoform profile (HP:0003642)2.57969465
49Bifid tongue (HP:0010297)2.57451365
50Acute lymphatic leukemia (HP:0006721)2.55413577
51Duodenal stenosis (HP:0100867)2.52632882
52Small intestinal stenosis (HP:0012848)2.52632882
53Anencephaly (HP:0002323)2.50871509
54Hyperglycinemia (HP:0002154)2.49482160
55Recurrent bronchitis (HP:0002837)2.49156817
56Septo-optic dysplasia (HP:0100842)2.48557590
57Abnormality of the renal collecting system (HP:0004742)2.47825882
58Cystic liver disease (HP:0006706)2.46824227
59Duplicated collecting system (HP:0000081)2.46636111
6011 pairs of ribs (HP:0000878)2.46309794
61Volvulus (HP:0002580)2.46166307
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.45268038
63Postaxial hand polydactyly (HP:0001162)2.44721789
64Rhinitis (HP:0012384)2.43618182
65Occipital encephalocele (HP:0002085)2.41230743
66Sloping forehead (HP:0000340)2.40678523
67Panhypogammaglobulinemia (HP:0003139)2.39428127
68Lymphoma (HP:0002665)2.38553278
69Abnormality of the fingertips (HP:0001211)2.37480476
70Amaurosis fugax (HP:0100576)2.35442014
71Optic nerve coloboma (HP:0000588)2.35196943
72Selective tooth agenesis (HP:0001592)2.31795762
73Breast hypoplasia (HP:0003187)2.31683461
74Gonadotropin excess (HP:0000837)2.31222865
75Muscle fiber atrophy (HP:0100295)2.30588314
76Absent thumb (HP:0009777)2.30461078
77Tubulointerstitial nephritis (HP:0001970)2.30215977
78Pancytopenia (HP:0001876)2.29912730
79Anophthalmia (HP:0000528)2.29114056
80Ectopic kidney (HP:0000086)2.28407953
81Supernumerary spleens (HP:0009799)2.28104002
82Abnormality of the carotid arteries (HP:0005344)2.26775387
83Abnormality of T cell physiology (HP:0011840)2.24666958
84Rhabdomyosarcoma (HP:0002859)2.23875196
85Nasal polyposis (HP:0100582)2.23864013
86Optic nerve hypoplasia (HP:0000609)2.22290603
87Aqueductal stenosis (HP:0002410)2.20931309
88Hepatoblastoma (HP:0002884)2.20597002
89Oligodactyly (hands) (HP:0001180)2.19848419
90Abnormality of T cells (HP:0002843)2.18584972
91Labial hypoplasia (HP:0000066)2.15172589
92Nephroblastoma (Wilms tumor) (HP:0002667)2.14565033
93Preaxial hand polydactyly (HP:0001177)2.14052129
94Poikiloderma (HP:0001029)2.13607628
95Specific learning disability (HP:0001328)2.13013700
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12673417
97Pallor (HP:0000980)2.12392053
98Premature graying of hair (HP:0002216)2.11210138
99Abnormal spermatogenesis (HP:0008669)2.10140399
100Pulmonary fibrosis (HP:0002206)2.09211452
101Abnormality of the duodenum (HP:0002246)2.08661154
102Narrow forehead (HP:0000341)2.08254721
103Drooling (HP:0002307)2.07386257
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06983649
105Sclerocornea (HP:0000647)2.06837957
106Basal cell carcinoma (HP:0002671)2.04463569
107Hyperventilation (HP:0002883)2.04350430
108Micropenis (HP:0000054)2.03592978
109Cellular immunodeficiency (HP:0005374)2.02555785
110Impulsivity (HP:0100710)2.02208996
111Decreased testicular size (HP:0008734)2.01745600
112Microretrognathia (HP:0000308)2.00287469
113Abnormality of glycine metabolism (HP:0010895)2.00285706
114Abnormality of serine family amino acid metabolism (HP:0010894)2.00285706
115Gastrointestinal atresia (HP:0002589)2.00285524
116Carpal bone hypoplasia (HP:0001498)1.99428962
117Abnormality of the renal cortex (HP:0011035)1.98986071
118Asplenia (HP:0001746)1.98682891
119Molar tooth sign on MRI (HP:0002419)1.96901397
120Abnormality of midbrain morphology (HP:0002418)1.96901397
121Dandy-Walker malformation (HP:0001305)1.96347261
122Abnormality of the parathyroid morphology (HP:0011766)1.95794060
123Short foot (HP:0001773)1.95048472
124Acute myeloid leukemia (HP:0004808)1.94942581
125Congenital hepatic fibrosis (HP:0002612)1.94783049
126Embryonal renal neoplasm (HP:0011794)1.94491045
127Recurrent viral infections (HP:0004429)1.94219663
128Rough bone trabeculation (HP:0100670)1.93791432
129Prolonged bleeding time (HP:0003010)1.93538606
130Median cleft lip (HP:0000161)1.92670381
131Renal hypoplasia (HP:0000089)1.91734712
132Abnormality of the metopic suture (HP:0005556)1.91467323
133Petechiae (HP:0000967)1.91107932
134Leukopenia (HP:0001882)1.89537604
135IgG deficiency (HP:0004315)1.89336259
136Hypoplastic female external genitalia (HP:0012815)1.88600315
137Abnormality of the columella (HP:0009929)1.88396642
138Hyperglycinuria (HP:0003108)1.88029915
139Patellar aplasia (HP:0006443)1.88006052
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.87946770
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.87304600
142Broad alveolar ridges (HP:0000187)1.87011818
143Pancreatic fibrosis (HP:0100732)1.85496056
144B lymphocytopenia (HP:0010976)1.84486646
145Abnormality of B cell number (HP:0010975)1.84486646
146Male pseudohermaphroditism (HP:0000037)1.84363198
147Excessive salivation (HP:0003781)1.83412836
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.82810307
149Bronchitis (HP:0012387)1.82357274
150Tracheoesophageal fistula (HP:0002575)1.82047454
151Abnormal respiratory epithelium morphology (HP:0012253)1.81045112
152Abnormal respiratory motile cilium morphology (HP:0005938)1.81045112
153Methylmalonic acidemia (HP:0002912)1.80136138
154Hypoplasia of the thymus (HP:0000778)1.80102369
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79420043
156Abnormal protein N-linked glycosylation (HP:0012347)1.79420043
157Abnormal protein glycosylation (HP:0012346)1.79420043
158Abnormal glycosylation (HP:0012345)1.79420043
159Absent/shortened dynein arms (HP:0200106)1.79074356
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.79074356
161Reduced antithrombin III activity (HP:0001976)1.78830757
162Recurrent fungal infections (HP:0002841)1.78799976
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.78389196
164Hip dysplasia (HP:0001385)1.77336413
165Neoplasm of the oral cavity (HP:0100649)1.77264732
166Recurrent sinusitis (HP:0011108)1.76988719
167Oculomotor apraxia (HP:0000657)1.76432263
168Aplasia/Hypoplasia of the lens (HP:0008063)1.74395748
169Multicystic kidney dysplasia (HP:0000003)1.73683260
170Scrotal hypoplasia (HP:0000046)1.73229706
171Astigmatism (HP:0000483)1.73075211
172Short tibia (HP:0005736)1.70376016
173Abnormal lung lobation (HP:0002101)1.69585591
174Prominent nasal bridge (HP:0000426)1.68794107
175Cutaneous finger syndactyly (HP:0010554)1.66434726
176Tubular atrophy (HP:0000092)1.64490790
177Vitreoretinal degeneration (HP:0000655)1.64134464
178Lissencephaly (HP:0001339)1.63490791
179Abnormality of macular pigmentation (HP:0008002)1.61422560
180Degeneration of the lateral corticospinal tracts (HP:0002314)1.61350850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.92790030
2FRK3.34038595
3TRIM283.14614823
4WNK32.98614627
5WEE12.73395931
6MAP4K12.72112543
7STK162.58007814
8BCR2.57520165
9BUB12.40119709
10MAP3K42.37357088
11BRD42.32906351
12STK38L2.32254811
13BMPR1B2.30889140
14TNIK2.30541651
15NEK22.27398551
16TXK2.18264751
17TSSK62.17377192
18MAP4K22.12547036
19SRPK12.12319855
20ATR2.11879823
21EPHA42.04448765
22NME22.03994160
23PLK41.97742799
24TTK1.97575452
25BRSK21.94705022
26NUAK11.86937047
27CCNB11.85779531
28CDK121.83822914
29VRK11.82813140
30EEF2K1.80432670
31RPS6KB21.78319403
32CDK71.73799543
33MKNK11.66120660
34PASK1.65650428
35FGFR21.64482156
36PLK11.56290569
37MAPK131.53359928
38ACVR1B1.44840288
39CSNK1G21.42890329
40PNCK1.40513653
41PIM11.40259582
42MAP3K141.39968000
43KIT1.39764861
44MAP2K71.38554062
45JAK31.38517840
46BTK1.37683882
47MKNK21.36685741
48RPS6KA41.35105676
49EIF2AK11.32290551
50FLT31.31275032
51TEC1.29874094
52CSNK1G11.29180394
53PINK11.24209878
54MAPKAPK31.20822361
55IRAK41.18108402
56YES11.16844973
57CHEK21.16604312
58STK41.16516912
59EPHA31.16055995
60GRK11.15783329
61AURKB1.15502854
62EIF2AK31.13913977
63CSNK1A1L1.13727342
64PLK21.13227506
65DAPK11.13025341
66CDK41.11999452
67CSNK1G31.11174028
68LATS11.09871713
69DYRK31.09277106
70MARK11.07170534
71NTRK21.05655344
72TLK11.05443031
73DYRK21.02400567
74ZAP700.99905352
75PLK30.99784081
76CHEK10.98219364
77PAK30.98004096
78IKBKE0.96621213
79ATM0.95392050
80CDK80.95339162
81SCYL20.95243685
82NEK10.94783103
83IRAK30.92854216
84IKBKB0.92823035
85SYK0.91242430
86TGFBR10.90342179
87MAP3K80.87479526
88STK30.87477836
89STK390.86197434
90PRKCE0.85775364
91BRSK10.85139905
92MAP2K40.84197092
93SGK20.83873155
94TAOK20.83714687
95CLK10.83357759
96MAPK150.81679548
97RPS6KB10.80726172
98STK100.80216825
99DYRK1A0.78209914
100EIF2AK20.77102360
101OXSR10.76916113
102NLK0.76728193
103ZAK0.76373253
104TYK20.75539898
105MAP3K130.75169048
106INSRR0.72986194
107LYN0.71889596
108CSF1R0.71504165
109FER0.70939241
110PRKCG0.69924064
111FGFR10.69590078
112CDK20.68415276
113CHUK0.68184100
114LCK0.67913822
115DYRK1B0.67416884
116WNK40.65559495
117CSNK2A20.63569652
118RPS6KA50.62899151
119PKN20.62501087
120PIM20.61991768
121BCKDK0.60613136
122AURKA0.59420418
123SGK4940.59218573
124SGK2230.59218573
125BRAF0.57412986
126AKT30.57039049
127GRK60.57031915
128CSNK2A10.56658096
129CDK60.55992925
130SIK30.52987512
131TAF10.50587104
132KSR10.50351647
133CAMK1G0.50043326
134CDK90.49349160
135STK240.48224572
136ADRBK20.47761813
137CASK0.47624531
138RPS6KA60.47007856
139CDK10.45478304
140ERBB30.45035305
141STK110.43635307
142MAP2K60.43316607
143NEK90.42555389
144TAOK30.41996245
145ERBB20.41442410
146UHMK10.40715530
147MATK0.40707410
148CDK30.40642115
149DAPK20.39762355
150CDK190.39597172
151HCK0.38774198
152PIK3CA0.37749060
153CSNK1D0.36952663
154MST40.36834868
155CAMKK20.36288599
156RPS6KC10.36187418
157RPS6KL10.36187418
158PRKD30.35722378
159MUSK0.35467364
160PBK0.34909696
161IRAK10.34767868
162CAMK2A0.33993078
163OBSCN0.32258895
164CSNK1A10.31079430

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92316661
2Mismatch repair_Homo sapiens_hsa034304.37522447
3Homologous recombination_Homo sapiens_hsa034403.66643296
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.46098008
5Base excision repair_Homo sapiens_hsa034103.24202340
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20710810
7Ribosome_Homo sapiens_hsa030103.08406724
8* Fanconi anemia pathway_Homo sapiens_hsa034603.06859002
9Propanoate metabolism_Homo sapiens_hsa006403.02298383
10Non-homologous end-joining_Homo sapiens_hsa034502.88865006
11Spliceosome_Homo sapiens_hsa030402.87846307
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78414098
13Nucleotide excision repair_Homo sapiens_hsa034202.72301525
14RNA polymerase_Homo sapiens_hsa030202.57435228
15Steroid biosynthesis_Homo sapiens_hsa001002.49902891
16RNA transport_Homo sapiens_hsa030132.45462033
17Butanoate metabolism_Homo sapiens_hsa006502.43038814
18Basal transcription factors_Homo sapiens_hsa030222.31189703
19Cell cycle_Homo sapiens_hsa041102.29552659
20Pyrimidine metabolism_Homo sapiens_hsa002402.23407272
21RNA degradation_Homo sapiens_hsa030182.21189544
22Proteasome_Homo sapiens_hsa030502.19190076
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13862534
24One carbon pool by folate_Homo sapiens_hsa006702.08143817
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03407534
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93150655
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88444364
28Primary immunodeficiency_Homo sapiens_hsa053401.83686788
29Basal cell carcinoma_Homo sapiens_hsa052171.79290535
30Nicotine addiction_Homo sapiens_hsa050331.78535285
31Hedgehog signaling pathway_Homo sapiens_hsa043401.74934378
32mRNA surveillance pathway_Homo sapiens_hsa030151.73847674
33Phototransduction_Homo sapiens_hsa047441.63565643
34Regulation of autophagy_Homo sapiens_hsa041401.57599516
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56890805
36Herpes simplex infection_Homo sapiens_hsa051681.50303584
37beta-Alanine metabolism_Homo sapiens_hsa004101.41948097
38Purine metabolism_Homo sapiens_hsa002301.41438605
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40501114
40p53 signaling pathway_Homo sapiens_hsa041151.38971469
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35446963
42Fatty acid elongation_Homo sapiens_hsa000621.34242437
43Antigen processing and presentation_Homo sapiens_hsa046121.30656499
44Measles_Homo sapiens_hsa051621.23381488
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22955072
46Hippo signaling pathway_Homo sapiens_hsa043901.22570984
47Tryptophan metabolism_Homo sapiens_hsa003801.21508062
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20643511
49Circadian rhythm_Homo sapiens_hsa047101.20124225
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.20086313
51Linoleic acid metabolism_Homo sapiens_hsa005911.20062372
52Epstein-Barr virus infection_Homo sapiens_hsa051691.20050826
53Taste transduction_Homo sapiens_hsa047421.18833944
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16170654
55Peroxisome_Homo sapiens_hsa041461.16102269
56Nitrogen metabolism_Homo sapiens_hsa009101.12617799
57Wnt signaling pathway_Homo sapiens_hsa043101.05012686
58Systemic lupus erythematosus_Homo sapiens_hsa053221.04369480
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.01388264
60GABAergic synapse_Homo sapiens_hsa047271.00657805
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99789070
62Hematopoietic cell lineage_Homo sapiens_hsa046400.98457406
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96988124
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96502330
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93830231
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.93458312
67TGF-beta signaling pathway_Homo sapiens_hsa043500.93324475
68Fatty acid degradation_Homo sapiens_hsa000710.92089194
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91647063
70Fatty acid metabolism_Homo sapiens_hsa012120.89939207
71Ether lipid metabolism_Homo sapiens_hsa005650.89845025
72Viral carcinogenesis_Homo sapiens_hsa052030.89499305
73Morphine addiction_Homo sapiens_hsa050320.85983556
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84557188
75Axon guidance_Homo sapiens_hsa043600.81425579
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.81294450
77Serotonergic synapse_Homo sapiens_hsa047260.81135527
78Histidine metabolism_Homo sapiens_hsa003400.79851835
79Legionellosis_Homo sapiens_hsa051340.79505401
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79299287
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78149464
82Pyruvate metabolism_Homo sapiens_hsa006200.77576915
83HTLV-I infection_Homo sapiens_hsa051660.77167049
84B cell receptor signaling pathway_Homo sapiens_hsa046620.76991994
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76347091
86Influenza A_Homo sapiens_hsa051640.76222091
87Circadian entrainment_Homo sapiens_hsa047130.76115494
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73672048
89Glutamatergic synapse_Homo sapiens_hsa047240.73101891
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71325038
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70005303
92N-Glycan biosynthesis_Homo sapiens_hsa005100.67588001
93Acute myeloid leukemia_Homo sapiens_hsa052210.67583633
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66329262
95Dopaminergic synapse_Homo sapiens_hsa047280.65860959
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65560833
97Hepatitis B_Homo sapiens_hsa051610.65041783
98Retinol metabolism_Homo sapiens_hsa008300.64672342
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.62590848
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.61451523
101Oocyte meiosis_Homo sapiens_hsa041140.60322921
102ABC transporters_Homo sapiens_hsa020100.58894158
103Other glycan degradation_Homo sapiens_hsa005110.58679462
104Insulin secretion_Homo sapiens_hsa049110.57903019
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57780842
106T cell receptor signaling pathway_Homo sapiens_hsa046600.57586958
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.57090732
108Selenocompound metabolism_Homo sapiens_hsa004500.56870060
109Pentose phosphate pathway_Homo sapiens_hsa000300.56723040
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53966034
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.53234965
112Apoptosis_Homo sapiens_hsa042100.52411173
113Chemical carcinogenesis_Homo sapiens_hsa052040.51450170
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50327074
115Leishmaniasis_Homo sapiens_hsa051400.50043538
116Ovarian steroidogenesis_Homo sapiens_hsa049130.49885794
117Long-term depression_Homo sapiens_hsa047300.49632254
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47810879
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47015262
120Allograft rejection_Homo sapiens_hsa053300.47001654
121Melanogenesis_Homo sapiens_hsa049160.46946480
122Olfactory transduction_Homo sapiens_hsa047400.46907486
123Tight junction_Homo sapiens_hsa045300.44927525
124Caffeine metabolism_Homo sapiens_hsa002320.44835204
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44702143
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44549705
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.43848220
128Graft-versus-host disease_Homo sapiens_hsa053320.42581301
129Adherens junction_Homo sapiens_hsa045200.41639517
130Metabolic pathways_Homo sapiens_hsa011000.41442982
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40373390
132Type I diabetes mellitus_Homo sapiens_hsa049400.39261099
133Dorso-ventral axis formation_Homo sapiens_hsa043200.39191384
134Shigellosis_Homo sapiens_hsa051310.38983725
135Colorectal cancer_Homo sapiens_hsa052100.38741012
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36670253
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35465805
138Glycerolipid metabolism_Homo sapiens_hsa005610.35216004
139Huntingtons disease_Homo sapiens_hsa050160.34356292
140cAMP signaling pathway_Homo sapiens_hsa040240.34118203
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33046516
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32939923
143Alcoholism_Homo sapiens_hsa050340.31702379
144Cocaine addiction_Homo sapiens_hsa050300.31358991
145Protein export_Homo sapiens_hsa030600.29518953
146Thyroid cancer_Homo sapiens_hsa052160.29130624
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28929615
148Galactose metabolism_Homo sapiens_hsa000520.28606158
149Chronic myeloid leukemia_Homo sapiens_hsa052200.27812080
150Osteoclast differentiation_Homo sapiens_hsa043800.27335348
151Asthma_Homo sapiens_hsa053100.27112944
152Arachidonic acid metabolism_Homo sapiens_hsa005900.26752074
153Small cell lung cancer_Homo sapiens_hsa052220.25755374
154Fructose and mannose metabolism_Homo sapiens_hsa000510.24931431
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24830718
156Notch signaling pathway_Homo sapiens_hsa043300.24817245
157Autoimmune thyroid disease_Homo sapiens_hsa053200.23222650
158Folate biosynthesis_Homo sapiens_hsa007900.23136716
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21332278
160TNF signaling pathway_Homo sapiens_hsa046680.20317683
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18747609
162MicroRNAs in cancer_Homo sapiens_hsa052060.16547799
163Platelet activation_Homo sapiens_hsa046110.14005678
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13655771
165Non-small cell lung cancer_Homo sapiens_hsa052230.13327834
166Pancreatic cancer_Homo sapiens_hsa052120.12950095
167Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12666708
168FoxO signaling pathway_Homo sapiens_hsa040680.12130395
169Toxoplasmosis_Homo sapiens_hsa051450.08896628
170Lysine degradation_Homo sapiens_hsa003100.08801460
171Biosynthesis of amino acids_Homo sapiens_hsa012300.07440756
172HIF-1 signaling pathway_Homo sapiens_hsa040660.06935296

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