POLDIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)5.95293270
2maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.05798356
3viral mRNA export from host cell nucleus (GO:0046784)4.79785416
4DNA strand renaturation (GO:0000733)4.64446489
5negative regulation of erythrocyte differentiation (GO:0045647)4.53705887
63-UTR-mediated mRNA stabilization (GO:0070935)4.46230662
7meiotic chromosome segregation (GO:0045132)4.44377427
8Golgi transport vesicle coating (GO:0048200)4.32426491
9COPI coating of Golgi vesicle (GO:0048205)4.32426491
10proline biosynthetic process (GO:0006561)4.21104573
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.20694797
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.20694797
13DNA unwinding involved in DNA replication (GO:0006268)4.13786146
14DNA double-strand break processing (GO:0000729)4.12003122
15spliceosomal tri-snRNP complex assembly (GO:0000244)4.10453676
16telomere maintenance via semi-conservative replication (GO:0032201)4.09837954
17kinetochore assembly (GO:0051382)3.98398703
18positive regulation of protein homooligomerization (GO:0032464)3.96112988
19kinetochore organization (GO:0051383)3.94042795
20regulation of double-strand break repair via homologous recombination (GO:0010569)3.90066463
21embryonic process involved in female pregnancy (GO:0060136)3.84340465
22pentose-phosphate shunt (GO:0006098)3.83127133
23telomere maintenance via recombination (GO:0000722)3.79829379
24cullin deneddylation (GO:0010388)3.71495315
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.69682669
26intracellular estrogen receptor signaling pathway (GO:0030520)3.68026951
27DNA strand elongation involved in DNA replication (GO:0006271)3.67453243
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63796528
29cellular hyperosmotic response (GO:0071474)3.59275139
30epithelial cell differentiation involved in prostate gland development (GO:0060742)3.58576148
31DNA strand elongation (GO:0022616)3.54841296
32protein deneddylation (GO:0000338)3.51794313
33RNA stabilization (GO:0043489)3.51048968
34mRNA stabilization (GO:0048255)3.51048968
35mitotic chromosome condensation (GO:0007076)3.50785133
36DNA ligation (GO:0006266)3.47930250
37transcription from mitochondrial promoter (GO:0006390)3.47880555
38protein-DNA complex disassembly (GO:0032986)3.46633943
39nucleosome disassembly (GO:0006337)3.46633943
40NADPH regeneration (GO:0006740)3.45590105
41peptidyl-arginine omega-N-methylation (GO:0035247)3.44687424
42mitotic recombination (GO:0006312)3.43791297
43apoptotic process involved in morphogenesis (GO:0060561)3.35555784
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34340135
45maturation of 5.8S rRNA (GO:0000460)3.31952651
46base-excision repair (GO:0006284)3.30259081
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.28150302
48regulation of NFAT protein import into nucleus (GO:0051532)3.27764865
49DNA deamination (GO:0045006)3.25875638
50mRNA cleavage (GO:0006379)3.25049345
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23102249
52mitotic sister chromatid segregation (GO:0000070)3.19779639
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.18680672
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18680672
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18680672
56DNA topological change (GO:0006265)3.18233038
57nuclear pore organization (GO:0006999)3.17397613
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16255243
59nuclear pore complex assembly (GO:0051292)3.15835284
60IMP biosynthetic process (GO:0006188)3.15685092
61regulation of double-strand break repair (GO:2000779)3.14815741
62purine nucleobase biosynthetic process (GO:0009113)3.14485210
63nucleobase biosynthetic process (GO:0046112)3.13138716
64telomere maintenance via telomere lengthening (GO:0010833)3.13053248
65regulation of chromatin binding (GO:0035561)3.13034773
66mismatch repair (GO:0006298)3.13008137
67formation of translation preinitiation complex (GO:0001731)3.12520380
68NIK/NF-kappaB signaling (GO:0038061)3.11772943
69protein localization to endosome (GO:0036010)3.07125818
70mitotic metaphase plate congression (GO:0007080)3.05163625
71protein complex localization (GO:0031503)3.01898861
72regulation of integrin activation (GO:0033623)3.00781632
73modulation by virus of host process (GO:0019054)2.99156171
74histone H4 deacetylation (GO:0070933)2.98499670
75histone H3-K36 demethylation (GO:0070544)2.95952684
76barbed-end actin filament capping (GO:0051016)2.94140667
77glucose catabolic process (GO:0006007)2.94087515
78regulation of DNA damage checkpoint (GO:2000001)2.92966978
79pore complex assembly (GO:0046931)2.92681587
80negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.92550102
81establishment of chromosome localization (GO:0051303)2.92230895
82cellular protein complex localization (GO:0034629)2.90708251
83oxidative demethylation (GO:0070989)2.89467877
84DNA integration (GO:0015074)2.86949791
85base-excision repair, AP site formation (GO:0006285)2.86936423
86peptidyl-arginine N-methylation (GO:0035246)2.86306734
87peptidyl-arginine methylation (GO:0018216)2.86306734
88proline metabolic process (GO:0006560)2.84241316
89telomere maintenance (GO:0000723)2.84182143
90DNA catabolic process, exonucleolytic (GO:0000738)2.83207036
91modulation by symbiont of host cellular process (GO:0044068)2.82888702
92maternal placenta development (GO:0001893)2.81402741
93telomere organization (GO:0032200)2.81030102
94DNA replication checkpoint (GO:0000076)2.80658055
95positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80474906
96regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80378638
97snRNA processing (GO:0016180)2.80217386
98cellular response to zinc ion (GO:0071294)2.79888730
99DNA replication initiation (GO:0006270)2.79370702
100protein K6-linked ubiquitination (GO:0085020)2.78591318
101sister chromatid segregation (GO:0000819)2.77608207
102negative regulation of mRNA processing (GO:0050686)2.76633358
103mitotic nuclear envelope disassembly (GO:0007077)2.76235942
104DNA demethylation (GO:0080111)2.76184292
105protein retention in ER lumen (GO:0006621)2.75791356
106histone arginine methylation (GO:0034969)2.75299229
107metaphase plate congression (GO:0051310)2.74680647
108ribosome biogenesis (GO:0042254)2.73637911
109response to laminar fluid shear stress (GO:0034616)2.73200640
110chromosome segregation (GO:0007059)2.72911911
111transcription-coupled nucleotide-excision repair (GO:0006283)2.71568067
112cellular response to interleukin-4 (GO:0071353)2.70799391
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70279335
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70279335
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.70279335
116modulation by symbiont of host immune response (GO:0052553)2.70279335
117positive regulation by symbiont of host defense response (GO:0052509)2.70279335
118modulation by symbiont of host defense response (GO:0052031)2.70279335
119adherens junction assembly (GO:0034333)2.70167273
120dosage compensation (GO:0007549)2.68899191
121* poly(A)+ mRNA export from nucleus (GO:0016973)2.68562708
122establishment of integrated proviral latency (GO:0075713)2.68074810
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67841077
124establishment of viral latency (GO:0019043)2.66058153
125positive regulation of receptor biosynthetic process (GO:0010870)2.65116489
126single strand break repair (GO:0000012)2.64487355
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.64160253
128modulation by virus of host morphology or physiology (GO:0019048)2.63307084
129regulation of spindle checkpoint (GO:0090231)2.63294687
130* mRNA export from nucleus (GO:0006406)2.63284652
131regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61417943
132regulation of mitotic spindle checkpoint (GO:1903504)2.61417943
133regulation of nucleobase-containing compound transport (GO:0032239)2.61097209
134protein localization to kinetochore (GO:0034501)2.60822005
135negative regulation of histone methylation (GO:0031061)2.59908222
136mitochondrial fusion (GO:0008053)2.59666603
137resolution of meiotic recombination intermediates (GO:0000712)2.59660142
138regulation of RNA export from nucleus (GO:0046831)2.59076452
139protein export from nucleus (GO:0006611)2.58813648
140glucose 6-phosphate metabolic process (GO:0051156)2.58079579
141regulation of mRNA stability (GO:0043488)2.57901345
142negative regulation of chromosome segregation (GO:0051985)2.57508584
143negative regulation of mRNA metabolic process (GO:1903312)2.57398635
144regulation of translational fidelity (GO:0006450)2.57161530
145ventricular trabecula myocardium morphogenesis (GO:0003222)2.56427201
146histone H4-K12 acetylation (GO:0043983)2.55622872
147regulation of RNA stability (GO:0043487)2.55585290
148double-strand break repair via nonhomologous end joining (GO:0006303)2.55469769
149non-recombinational repair (GO:0000726)2.55469769
150regulation of G0 to G1 transition (GO:0070316)2.54588787
151RNA localization (GO:0006403)2.54247533
152response to interleukin-4 (GO:0070670)2.53964457
153DNA synthesis involved in DNA repair (GO:0000731)2.53881562
154CENP-A containing nucleosome assembly (GO:0034080)2.51998666
155regulation of protein homooligomerization (GO:0032462)2.51870940
156attachment of spindle microtubules to kinetochore (GO:0008608)2.51689785
157histone mRNA catabolic process (GO:0071044)2.51002487
158glycolytic process (GO:0006096)2.50051413
159snRNA metabolic process (GO:0016073)2.49994180
160termination of RNA polymerase II transcription (GO:0006369)2.49776087
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.49666545
162positive regulation of chromosome segregation (GO:0051984)2.49609430
163chromatin remodeling at centromere (GO:0031055)2.47231854
164negative regulation of mast cell activation (GO:0033004)2.47027217
165pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.46884629
166recombinational repair (GO:0000725)2.46850827
167cellular response to epidermal growth factor stimulus (GO:0071364)2.46786195
168mitochondrial DNA metabolic process (GO:0032042)2.46723120
169nuclear envelope disassembly (GO:0051081)2.46424782
170membrane disassembly (GO:0030397)2.46424782
171regulation of response to osmotic stress (GO:0047484)2.46223464
172* RNA export from nucleus (GO:0006405)2.45868627
173response to muramyl dipeptide (GO:0032495)2.45730401
174mannose metabolic process (GO:0006013)2.45001987
175histone H3 deacetylation (GO:0070932)2.44791213
176regulation of early endosome to late endosome transport (GO:2000641)2.44428607
177negative regulation of androgen receptor signaling pathway (GO:0060766)2.43674318
178negative regulation of RNA splicing (GO:0033119)2.43490679
179histone deacetylation (GO:0016575)2.43411952
180histone lysine demethylation (GO:0070076)2.40917354
181activation of Rac GTPase activity (GO:0032863)2.40084009
182positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.38726535
183regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.38726535
184positive regulation of nuclease activity (GO:0032075)2.38438736
185stress fiber assembly (GO:0043149)2.37758959
186negative regulation of microtubule polymerization (GO:0031115)2.36325571
187activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36238878
188histone demethylation (GO:0016577)2.36233860
189convergent extension (GO:0060026)2.33283939
190positive regulation of gamma-delta T cell activation (GO:0046645)2.33251893
191negative regulation of cell killing (GO:0031342)2.30389115
192negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30389115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.50114983
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32118983
3MYC_22102868_ChIP-Seq_BL_Human3.27412493
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.08071549
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06100693
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.96829392
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92106210
8VDR_21846776_ChIP-Seq_THP-1_Human2.69550445
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62387673
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.55192708
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53705221
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43009550
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.32163813
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27841292
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20714184
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19737695
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13391897
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.13010273
19* LXR_22292898_ChIP-Seq_THP-1_Human2.10399614
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08777730
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.08163581
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.07854624
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.06763977
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06539692
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05283996
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04881972
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04770997
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.04521634
29* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04117919
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01882558
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97138514
32ELK1_19687146_ChIP-ChIP_HELA_Human1.96230892
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95683333
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.93120263
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92744808
36TCF7_22412390_ChIP-Seq_EML_Mouse1.91195056
37* SRF_21415370_ChIP-Seq_HL-1_Mouse1.89531814
38KDM2B_26808549_Chip-Seq_DND41_Human1.87487756
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.86642772
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86202934
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.86061258
42VDR_23849224_ChIP-Seq_CD4+_Human1.84641250
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84064886
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82975110
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.82964647
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82762449
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81396803
48* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77204106
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.76308906
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76087686
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75205730
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74207757
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71823537
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70111764
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69867323
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68977165
57* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66768737
58ZNF263_19887448_ChIP-Seq_K562_Human1.66433039
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61604007
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61316323
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61316323
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61316323
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60576351
64RACK7_27058665_Chip-Seq_MCF-7_Human1.60102705
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58732342
66* GABP_19822575_ChIP-Seq_HepG2_Human1.58725581
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58320947
68CLOCK_20551151_ChIP-Seq_293T_Human1.57961982
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57270469
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55462956
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51684592
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50742917
73* DCP1A_22483619_ChIP-Seq_HELA_Human1.48513715
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.47961757
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46633994
76* FOXP3_21729870_ChIP-Seq_TREG_Human1.44865696
77MAF_26560356_Chip-Seq_TH1_Human1.44712990
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44404415
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43458922
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41615146
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41610678
82UTX_26944678_Chip-Seq_JUKART_Human1.41364423
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40989611
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39959890
85KDM2B_26808549_Chip-Seq_K562_Human1.39177746
86TFEB_21752829_ChIP-Seq_HELA_Human1.37029652
87VDR_24763502_ChIP-Seq_THP-1_Human1.34795456
88* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34275430
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.32217947
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31867832
91MAF_26560356_Chip-Seq_TH2_Human1.30402395
92* TTF2_22483619_ChIP-Seq_HELA_Human1.29531200
93* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29050323
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.28929982
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.28488046
96KDM5A_27292631_Chip-Seq_BREAST_Human1.27585978
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27435843
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27232540
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.25944991
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25325986
101* XRN2_22483619_ChIP-Seq_HELA_Human1.23652464
102P68_20966046_ChIP-Seq_HELA_Human1.22561103
103NCOR1_26117541_ChIP-Seq_K562_Human1.22453732
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22284946
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22060023
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22001608
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.21444963
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20757817
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.19807185
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19350841
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19166738
112CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17698796
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17244070
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17008710
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16342336
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15918101
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15691648
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15440530
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15354321
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13183920
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13021352
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11969814
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09926556
124* SMC4_20622854_ChIP-Seq_HELA_Human1.09452500
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09327498
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09081554
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08771544
128* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08414378
129BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08050764
130NANOG_21062744_ChIP-ChIP_HESCs_Human1.07624525
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06885195
132SPI1_23547873_ChIP-Seq_NB4_Human1.06740105
133AR_21909140_ChIP-Seq_LNCAP_Human1.05565397
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05401533
135CREB1_26743006_Chip-Seq_LNCaP_Human1.04890808
136ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03872603
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03098737
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02607300
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02317304
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01169825
141OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00752517
142ELF1_20517297_ChIP-Seq_JURKAT_Human1.00035751
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98473445
144* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96988127
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96685399
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95573101
147CIITA_25753668_ChIP-Seq_RAJI_Human0.95178100
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95061360
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94780979
150* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94736113
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93890545
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93266790
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92695371
154GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89541089
155NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88994335
156* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87653642
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86233464
158IRF1_19129219_ChIP-ChIP_H3396_Human0.85676249
159* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83134756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.12649860
2MP0010094_abnormal_chromosome_stability3.62518990
3MP0001849_ear_inflammation3.44046383
4MP0008260_abnormal_autophagy3.39198233
5MP0008058_abnormal_DNA_repair3.31442986
6MP0003705_abnormal_hypodermis_morpholog3.27062533
7MP0005451_abnormal_body_composition3.25556563
8MP0005171_absent_coat_pigmentation3.03010756
9MP0008877_abnormal_DNA_methylation2.93135043
10MP0004858_abnormal_nervous_system2.79588499
11MP0003111_abnormal_nucleus_morphology2.67399651
12MP0003693_abnormal_embryo_hatching2.61968097
13MP0003077_abnormal_cell_cycle2.51726953
14MP0003436_decreased_susceptibility_to2.49752577
15MP0008007_abnormal_cellular_replicative2.46157647
16MP0003786_premature_aging2.37118818
17MP0010030_abnormal_orbit_morphology2.35647137
18MP0004957_abnormal_blastocyst_morpholog2.18341264
19MP0005058_abnormal_lysosome_morphology2.03660922
20MP0000015_abnormal_ear_pigmentation2.01263779
21MP0009278_abnormal_bone_marrow2.01088423
22MP0003303_peritoneal_inflammation1.87235326
23MP0002877_abnormal_melanocyte_morpholog1.77341917
24MP0003566_abnormal_cell_adhesion1.76386044
25MP0003890_abnormal_embryonic-extraembry1.71023846
26MP0001545_abnormal_hematopoietic_system1.70627966
27MP0005397_hematopoietic_system_phenotyp1.70627966
28MP0003300_gastrointestinal_ulcer1.69139424
29MP0003123_paternal_imprinting1.65355879
30MP0008932_abnormal_embryonic_tissue1.65040594
31MP0003941_abnormal_skin_development1.64207460
32MP0002396_abnormal_hematopoietic_system1.64010943
33MP0000537_abnormal_urethra_morphology1.61971819
34MP0003172_abnormal_lysosome_physiology1.61125278
35MP0003943_abnormal_hepatobiliary_system1.56722661
36MP0004947_skin_inflammation1.52890898
37MP0002132_abnormal_respiratory_system1.49331840
38MP0005174_abnormal_tail_pigmentation1.49171616
39MP0002009_preneoplasia1.48224960
40MP0003453_abnormal_keratinocyte_physiol1.45127029
41MP0001835_abnormal_antigen_presentation1.42802010
42MP0003221_abnormal_cardiomyocyte_apopto1.42178177
43MP0009672_abnormal_birth_weight1.41887437
44MP0004782_abnormal_surfactant_physiolog1.41778209
45MP0002163_abnormal_gland_morphology1.40745166
46MP0008995_early_reproductive_senescence1.38040964
47MP0004233_abnormal_muscle_weight1.36498163
48MP0000350_abnormal_cell_proliferation1.36476478
49MP0000678_abnormal_parathyroid_gland1.32633833
50MP0009333_abnormal_splenocyte_physiolog1.29719796
51MP0004185_abnormal_adipocyte_glucose1.28495619
52MP0000516_abnormal_urinary_system1.28395456
53MP0005367_renal/urinary_system_phenotyp1.28395456
54MP0005501_abnormal_skin_physiology1.27949559
55MP0010352_gastrointestinal_tract_polyps1.27553378
56MP0002089_abnormal_postnatal_growth/wei1.27266823
57MP0003121_genomic_imprinting1.22250318
58MP0000490_abnormal_crypts_of1.22172516
59MP0003329_amyloid_beta_deposits1.21859117
60MP0005380_embryogenesis_phenotype1.20168984
61MP0001672_abnormal_embryogenesis/_devel1.20168984
62MP0003763_abnormal_thymus_physiology1.20083620
63MP0003091_abnormal_cell_migration1.19245248
64MP0001293_anophthalmia1.19220523
65MP0000858_altered_metastatic_potential1.17999589
66MP0005623_abnormal_meninges_morphology1.15540531
67MP0009053_abnormal_anal_canal1.15506691
68MP0005257_abnormal_intraocular_pressure1.15307648
69MP0002086_abnormal_extraembryonic_tissu1.13994090
70MP0001119_abnormal_female_reproductive1.13071516
71MP0005075_abnormal_melanosome_morpholog1.12907296
72MP0001697_abnormal_embryo_size1.12700474
73MP0003115_abnormal_respiratory_system1.12021824
74MP0005621_abnormal_cell_physiology1.11748926
75MP0002405_respiratory_system_inflammati1.11069396
76MP0002148_abnormal_hypersensitivity_rea1.10839012
77MP0001186_pigmentation_phenotype1.09881779
78MP0002796_impaired_skin_barrier1.08765759
79MP0004264_abnormal_extraembryonic_tissu1.07625391
80MP0002019_abnormal_tumor_incidence1.07254538
81MP0004197_abnormal_fetal_growth/weight/1.06073317
82MP0010307_abnormal_tumor_latency1.06048744
83MP0003984_embryonic_growth_retardation1.05966286
84MP0004808_abnormal_hematopoietic_stem1.05312874
85MP0005025_abnormal_response_to1.04596425
86MP0009697_abnormal_copulation1.04174483
87MP0003787_abnormal_imprinting1.04092425
88MP0000371_diluted_coat_color1.03448700
89MP0000313_abnormal_cell_death1.03421645
90MP0006292_abnormal_olfactory_placode1.02264776
91MP0002088_abnormal_embryonic_growth/wei1.00678226
92MP0002938_white_spotting1.00043436
93MP0001346_abnormal_lacrimal_gland0.99116689
94MP0005409_darkened_coat_color0.98945255
95MP0009785_altered_susceptibility_to0.98034848
96MP0002210_abnormal_sex_determination0.97989601
97MP0002398_abnormal_bone_marrow0.97971736
98MP0001790_abnormal_immune_system0.97945462
99MP0005387_immune_system_phenotype0.97945462
100MP0001188_hyperpigmentation0.97879467
101MP0000566_synostosis0.95873929
102MP0005394_taste/olfaction_phenotype0.95658495
103MP0005499_abnormal_olfactory_system0.95658495
104MP0001730_embryonic_growth_arrest0.95337341
105MP0003119_abnormal_digestive_system0.94695607
106MP0002085_abnormal_embryonic_tissue0.93761518
107MP0002075_abnormal_coat/hair_pigmentati0.93362834
108MP0010234_abnormal_vibrissa_follicle0.92559141
109MP0003656_abnormal_erythrocyte_physiolo0.92556687
110MP0005671_abnormal_response_to0.90769442
111MP0002419_abnormal_innate_immunity0.90738532
112MP0005384_cellular_phenotype0.89519298
113MP0000689_abnormal_spleen_morphology0.88547861
114MP0005000_abnormal_immune_tolerance0.87684476
115MP0002429_abnormal_blood_cell0.87162169
116MP0002249_abnormal_larynx_morphology0.85196919
117MP0002092_abnormal_eye_morphology0.85036455
118MP0005076_abnormal_cell_differentiation0.84209932
119MP0003634_abnormal_glial_cell0.84058576
120MP0005389_reproductive_system_phenotype0.83164928
121MP0010630_abnormal_cardiac_muscle0.82815401
122MP0001915_intracranial_hemorrhage0.82707917
123MP0010155_abnormal_intestine_physiology0.82650794
124MP0002653_abnormal_ependyma_morphology0.82301752
125MP0002420_abnormal_adaptive_immunity0.81453204
126MP0003191_abnormal_cellular_cholesterol0.81269418
127MP0009931_abnormal_skin_appearance0.79762392
128MP0003186_abnormal_redox_activity0.79441623
129MP0000716_abnormal_immune_system0.79338444
130MP0005646_abnormal_pituitary_gland0.78822114
131MP0001145_abnormal_male_reproductive0.78621724
132MP0002095_abnormal_skin_pigmentation0.78517233
133MP0003755_abnormal_palate_morphology0.78512894
134MP0002084_abnormal_developmental_patter0.78356578
135MP0000703_abnormal_thymus_morphology0.78233974
136MP0003942_abnormal_urinary_system0.78211042
137MP0002277_abnormal_respiratory_mucosa0.77765576
138MP0002080_prenatal_lethality0.77457356
139MP0000733_abnormal_muscle_development0.77325114
140MP0003567_abnormal_fetal_cardiomyocyte0.77208202
141MP0009840_abnormal_foam_cell0.76215611
142MP0002722_abnormal_immune_system0.76187549
143MP0002452_abnormal_antigen_presenting0.75749624
144MP0002876_abnormal_thyroid_physiology0.75186442
145MP0003136_yellow_coat_color0.75079062
146MP0008438_abnormal_cutaneous_collagen0.74520341
147MP0003828_pulmonary_edema0.73882228
148MP0000049_abnormal_middle_ear0.73853989
149MP0001800_abnormal_humoral_immune0.73384103
150MP0002282_abnormal_trachea_morphology0.73357002
151MP0001819_abnormal_immune_cell0.72451690
152MP0003385_abnormal_body_wall0.72445855
153MP0000685_abnormal_immune_system0.72002731
154MP0003718_maternal_effect0.71805002

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)3.65888085
2Cholecystitis (HP:0001082)3.58173868
3Abnormal gallbladder physiology (HP:0012438)3.58173868
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45547270
5Chromsome breakage (HP:0040012)3.42546009
6Hyperacusis (HP:0010780)3.14897033
7Patellar aplasia (HP:0006443)3.09128202
8Birth length less than 3rd percentile (HP:0003561)2.96790606
9Abnormality of the anterior horn cell (HP:0006802)2.96600802
10Degeneration of anterior horn cells (HP:0002398)2.96600802
11Aplasia/Hypoplasia of the patella (HP:0006498)2.95595809
12Tongue fasciculations (HP:0001308)2.93424332
13Rib fusion (HP:0000902)2.88040485
14Peripheral hypomyelination (HP:0007182)2.86131018
15Nephroblastoma (Wilms tumor) (HP:0002667)2.83165770
16Intestinal fistula (HP:0100819)2.81279252
17Rectovaginal fistula (HP:0000143)2.77442394
18Rectal fistula (HP:0100590)2.77442394
19Abnormality of male internal genitalia (HP:0000022)2.73017010
20Centrally nucleated skeletal muscle fibers (HP:0003687)2.68758889
21Abnormality of the ileum (HP:0001549)2.68728415
22Embryonal renal neoplasm (HP:0011794)2.67004834
23Abnormal hair whorl (HP:0010721)2.65445311
24Pustule (HP:0200039)2.63156749
25Long palpebral fissure (HP:0000637)2.60421928
26Broad distal phalanx of finger (HP:0009836)2.52794931
27Cortical dysplasia (HP:0002539)2.45871184
28Disproportionate tall stature (HP:0001519)2.43812517
29Muscle fibrillation (HP:0010546)2.43737573
30Prostate neoplasm (HP:0100787)2.40414447
31Insomnia (HP:0100785)2.37576509
32Poikiloderma (HP:0001029)2.37282586
33Abnormality of the labia minora (HP:0012880)2.36911687
34Premature graying of hair (HP:0002216)2.36143669
35Trigonocephaly (HP:0000243)2.33476427
36Meckel diverticulum (HP:0002245)2.33193133
37Eczematoid dermatitis (HP:0000976)2.31199857
38Obstructive sleep apnea (HP:0002870)2.30479999
39Intestinal atresia (HP:0011100)2.28541560
40Vaginal fistula (HP:0004320)2.27124949
41Cellulitis (HP:0100658)2.27001949
42Reticulocytosis (HP:0001923)2.25523093
43Progressive external ophthalmoplegia (HP:0000590)2.25441119
44Flat acetabular roof (HP:0003180)2.24776228
45Segmental peripheral demyelination/remyelination (HP:0003481)2.24650896
46Abnormal lung lobation (HP:0002101)2.24484139
47Ulnar bowing (HP:0003031)2.24268058
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.24085838
49Bifid uvula (HP:0000193)2.23776085
50Cutaneous melanoma (HP:0012056)2.23344783
5111 pairs of ribs (HP:0000878)2.23156479
52Pancreatic islet-cell hyperplasia (HP:0004510)2.22729400
53Pointed chin (HP:0000307)2.22357788
54Spinal cord lesions (HP:0100561)2.22110173
55Syringomyelia (HP:0003396)2.22110173
56Bilateral sensorineural hearing impairment (HP:0008619)2.21530456
57IgA deficiency (HP:0002720)2.20804439
58Absent radius (HP:0003974)2.20063720
59Broad face (HP:0000283)2.19818954
60Ectopic kidney (HP:0000086)2.19676470
61Abnormality of chromosome stability (HP:0003220)2.19403111
62Abnormality of the aortic arch (HP:0012303)2.18341431
63Myelodysplasia (HP:0002863)2.18249644
64Abnormality of the calcaneus (HP:0008364)2.18132378
65Cystic hygroma (HP:0000476)2.17436185
66Capillary hemangiomas (HP:0005306)2.17251714
67Biconcave vertebral bodies (HP:0004586)2.15560802
68Progressive sensorineural hearing impairment (HP:0000408)2.15332271
69Deep philtrum (HP:0002002)2.15250528
70Breast hypoplasia (HP:0003187)2.14565855
71Vertebral arch anomaly (HP:0008438)2.12924693
72Achilles tendon contracture (HP:0001771)2.11498355
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11250666
74High anterior hairline (HP:0009890)2.11141788
75Agnosia (HP:0010524)2.10658867
76Mesomelia (HP:0003027)2.09887082
77Neuronal loss in central nervous system (HP:0002529)2.09560504
78Bowel incontinence (HP:0002607)2.09244398
79Increased variability in muscle fiber diameter (HP:0003557)2.08686337
80Flattened epiphyses (HP:0003071)2.07605727
81Volvulus (HP:0002580)2.06925221
82Upper limb amyotrophy (HP:0009129)2.06852140
83Distal upper limb amyotrophy (HP:0007149)2.06852140
84Absent thumb (HP:0009777)2.06477969
85Vertebral compression fractures (HP:0002953)2.06324764
86Type I transferrin isoform profile (HP:0003642)2.05131003
87Optic neuritis (HP:0100653)2.04661667
88Retrobulbar optic neuritis (HP:0100654)2.04661667
89Hypochromic microcytic anemia (HP:0004840)2.03174654
90Spastic diplegia (HP:0001264)2.02357065
91Abnormality of incisor morphology (HP:0011063)2.01116295
92Optic nerve coloboma (HP:0000588)2.00771000
93Aplasia/hypoplasia of the humerus (HP:0006507)1.99878984
94Vertebral hypoplasia (HP:0008417)1.98959892
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.98959892
96Absent forearm bone (HP:0003953)1.98931346
97Aplasia involving forearm bones (HP:0009822)1.98931346
98Abnormality of the preputium (HP:0100587)1.98488307
99Short 5th finger (HP:0009237)1.98329683
100Spinal muscular atrophy (HP:0007269)1.98258333
101Hand muscle atrophy (HP:0009130)1.97864932
102Short humerus (HP:0005792)1.97661062
103Abnormal large intestine physiology (HP:0012700)1.97408761
104Shallow orbits (HP:0000586)1.97342367
105Protrusio acetabuli (HP:0003179)1.96834092
106Type 2 muscle fiber atrophy (HP:0003554)1.96403686
107Broad palm (HP:0001169)1.94443578
108Distal lower limb amyotrophy (HP:0008944)1.94051001
109Facial hemangioma (HP:0000329)1.93955924
110Lip pit (HP:0100267)1.93914126
111Abnormality of the incisor (HP:0000676)1.93399648
112Loss of speech (HP:0002371)1.91928651
113Meningioma (HP:0002858)1.90543304
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.90070377
115Hammertoe (HP:0001765)1.89780633
116Abnormality of the nasal septum (HP:0000419)1.88871831
117Selective tooth agenesis (HP:0001592)1.88603383
118Abnormality of the thoracic spine (HP:0100711)1.87738894
119Abnormality of skeletal muscle fiber size (HP:0012084)1.84185540
120Thoracic kyphosis (HP:0002942)1.83918177
121Ragged-red muscle fibers (HP:0003200)1.83576502
122Deep palmar crease (HP:0006191)1.82716389
123Alveolar cell carcinoma (HP:0006519)1.82316885
124Abnormality of the renal collecting system (HP:0004742)1.82203757
125Cholelithiasis (HP:0001081)1.82159418
126Bone marrow hypocellularity (HP:0005528)1.81729816
127Thin ribs (HP:0000883)1.80840608
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80401367
129Increased IgE level (HP:0003212)1.80075012
130Myopathic facies (HP:0002058)1.79086348
131Mitral regurgitation (HP:0001653)1.79055992
132True hermaphroditism (HP:0010459)1.78731444
133Long clavicles (HP:0000890)1.77665254
134Median cleft lip (HP:0000161)1.77437780
135Keratoconjunctivitis sicca (HP:0001097)1.77151186
136Hypercortisolism (HP:0001578)1.77026453
137Increased number of teeth (HP:0011069)1.75402147
138Abnormality of reticulocytes (HP:0004312)1.74953166
139Arnold-Chiari malformation (HP:0002308)1.74439869
140Cervical subluxation (HP:0003308)1.73282702
141Abnormality of the Achilles tendon (HP:0005109)1.72892273
142Abnormal number of incisors (HP:0011064)1.72862888
143Spina bifida occulta (HP:0003298)1.72514737
144Aplasia of the musculature (HP:0100854)1.72126669
145Alopecia of scalp (HP:0002293)1.71931711
146Recurrent abscess formation (HP:0002722)1.71754435
147Progressive muscle weakness (HP:0003323)1.71657131
148Turricephaly (HP:0000262)1.71390694
149Flared metaphyses (HP:0003015)1.70717463
150Termporal pattern (HP:0011008)1.70573195
151Insidious onset (HP:0003587)1.70573195
152Ankyloglossia (HP:0010296)1.70413466
153Keratoconjunctivitis (HP:0001096)1.69974259
154Muscle fiber atrophy (HP:0100295)1.69241173
155Genu recurvatum (HP:0002816)1.69089564
156Athetosis (HP:0002305)1.69020204
157Albinism (HP:0001022)1.69014199
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68784470
159Distal sensory impairment (HP:0002936)1.67944514
160Shawl scrotum (HP:0000049)1.67284101
161Abnormality of macrophages (HP:0004311)1.67008450
162Metaphyseal cupping (HP:0003021)1.66833455
163Duplicated collecting system (HP:0000081)1.66045073
164Duodenal stenosis (HP:0100867)1.66039770
165Small intestinal stenosis (HP:0012848)1.66039770
166Abnormality of the salivary glands (HP:0010286)1.65139538
167Ankle clonus (HP:0011448)1.65016886
168Medulloblastoma (HP:0002885)1.64996981
169Nonimmune hydrops fetalis (HP:0001790)1.64808814
170Increased connective tissue (HP:0009025)1.64703840
171Lymphoma (HP:0002665)1.64629855
172White forelock (HP:0002211)1.64018165
173Clubbing of toes (HP:0100760)1.63803145
174Upper motor neuron abnormality (HP:0002127)1.63595469
175Patellar dislocation (HP:0002999)1.63055477
176Premature rupture of membranes (HP:0001788)1.62247270
177Cerebral aneurysm (HP:0004944)1.61979219
178Increased nuchal translucency (HP:0010880)1.61937180
179Poor coordination (HP:0002370)1.61534365
180Premature skin wrinkling (HP:0100678)1.61109439
181Microvesicular hepatic steatosis (HP:0001414)1.60792678
182Abnormality of the distal phalanges of the toes (HP:0010182)1.59125005
183Broad thumb (HP:0011304)1.59111523
184Abnormal vertebral ossification (HP:0100569)1.58832220
185Abnormality of the intervertebral disk (HP:0005108)1.58791998
186Absent epiphyses (HP:0010577)1.58704751
187Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58704751
188Proximal placement of thumb (HP:0009623)1.57051660
189Small epiphyses (HP:0010585)1.55529319
190Deviation of the thumb (HP:0009603)1.55277613
191Onion bulb formation (HP:0003383)1.54626314
192Growth hormone excess (HP:0000845)1.54013617
193Shoulder girdle muscle weakness (HP:0003547)1.53158937
194Decreased motor nerve conduction velocity (HP:0003431)1.52641595
195Abnormality of the fingertips (HP:0001211)1.52364821
196Broad phalanges of the hand (HP:0009768)1.52161104
197Overriding aorta (HP:0002623)1.51791861
198Thin bony cortex (HP:0002753)1.51591681
199Gastrointestinal inflammation (HP:0004386)1.51041393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.01269642
2AKT33.93625626
3TRIB33.45272906
4EEF2K2.88155045
5ERN12.50843703
6MAP3K102.49383643
7YES12.46267962
8PIM22.44709485
9ERBB32.42134340
10MAP3K142.40276689
11ZAK2.30223776
12MAP3K62.20479867
13STK38L2.06609510
14KSR22.00029314
15SIK31.93152420
16PRPF4B1.93020586
17DDR21.90791982
18CDC71.90312015
19TSSK61.90102287
20RIPK11.85949977
21FGFR41.77851631
22MATK1.72423350
23BUB11.68374878
24STK241.68152922
25PIM11.68119988
26SIK11.67559141
27PLK41.66748945
28DAPK11.63493016
29RPS6KL11.63425965
30RPS6KC11.63425965
31SRPK11.61750322
32IRAK41.58892909
33CDK71.58886526
34TRPM71.57578505
35RPS6KA61.57148932
36PINK11.54597910
37SIK21.53608074
38BMPR21.52715361
39EPHB11.51328914
40ICK1.50479210
41SGK21.49703920
42BRSK21.49619395
43ATR1.47440493
44MAP2K31.44394113
45CCNB11.41937749
46TXK1.41315456
47CDK81.40225389
48MKNK11.39708201
49PLK11.39021655
50MKNK21.38636759
51MAPK151.36036194
52PLK31.33001088
53TESK21.31561803
54PAK41.21150838
55CLK11.20192167
56CHUK1.19990640
57MAP3K111.18343898
58BRD41.17557714
59MARK21.16658816
60MAP4K11.14637362
61CDK41.14232922
62PDGFRA1.12801101
63BMPR1B1.12068784
64DYRK1B1.11231804
65PASK1.10384653
66CASK1.09179328
67PKN21.07854248
68VRK21.07795384
69CHEK21.06623404
70PRKD31.06291483
71NME21.06142236
72BRSK11.05655761
73RAF11.05332037
74JAK31.05082071
75LRRK21.04405907
76IKBKB1.03699706
77STK31.02123657
78EIF2AK11.01469422
79ARAF1.00376764
80TAOK11.00309401
81MAP3K81.00301781
82WEE10.98205645
83SGK30.97500243
84MAP3K130.95592453
85BMX0.95585921
86PLK20.95106381
87STK40.93383836
88TAOK20.93360180
89NEK10.92268530
90IRAK30.89696553
91VRK10.88458956
92PTK60.87909441
93KSR10.87249919
94PRKD20.86494863
95ACVR1B0.86087474
96BRAF0.85897687
97TYRO30.84493657
98RIPK40.83852711
99ATM0.82375610
100EPHA30.81692485
101EIF2AK20.80511854
102CSK0.80031891
103BCR0.79211475
104CDK120.78828326
105FGR0.77514402
106MTOR0.77168157
107EPHA20.74307749
108TGFBR10.74271316
109TTK0.74046200
110AURKB0.72921344
111TESK10.71624424
112TTN0.70409169
113NEK90.70353751
114CSNK2A10.68565922
115KDR0.67672848
116NUAK10.64684487
117MST40.64144621
118MAP3K10.63428020
119* CHEK10.63153741
120CDK11A0.63134999
121RPS6KA20.62128289
122CDK190.61894322
123CDK20.58908252
124HIPK20.57759574
125CDK140.57584798
126CDK150.57041050
127* RPS6KB10.56306565
128LMTK20.54934296
129MAP3K30.54567266
130BTK0.53857063
131TEC0.53567985
132RPS6KA10.53164865
133TYK20.52896537
134ALK0.52815957
135MOS0.52770196
136CDK180.52583314
137NEK60.52236205
138CDC42BPA0.52002259
139CDK90.49913532
140ZAP700.49873301
141MAPK30.47539887
142LATS20.47484465
143MAPKAPK20.47309813
144RET0.46253166
145CDK60.45971645
146NTRK10.45408278
147LYN0.45299832
148NEK20.45247637
149EIF2AK30.44526709
150AURKA0.43642555
151HCK0.42976932
152SGK4940.42829313
153SGK2230.42829313
154CDK10.42514071
155UHMK10.41449918
156PAK60.41108620
157MAPK110.40715257
158SCYL20.40668177
159MELK0.40112628
160MAP3K50.40103862
161PRKCD0.38637446
162STK100.37844283
163CSNK2A20.37319269

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.25639043
2DNA replication_Homo sapiens_hsa030303.97491371
3Base excision repair_Homo sapiens_hsa034103.88747179
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04130043
5Homologous recombination_Homo sapiens_hsa034402.89783518
6Proteasome_Homo sapiens_hsa030502.50181433
7Nucleotide excision repair_Homo sapiens_hsa034202.48296734
8Fanconi anemia pathway_Homo sapiens_hsa034602.46646081
9Spliceosome_Homo sapiens_hsa030402.34867846
10Cell cycle_Homo sapiens_hsa041102.32671045
11RNA transport_Homo sapiens_hsa030132.30494069
12RNA polymerase_Homo sapiens_hsa030202.14752854
13Non-homologous end-joining_Homo sapiens_hsa034501.96072297
14Basal transcription factors_Homo sapiens_hsa030221.95540136
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92491614
16mRNA surveillance pathway_Homo sapiens_hsa030151.89189151
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.82172608
18One carbon pool by folate_Homo sapiens_hsa006701.76720420
19Bladder cancer_Homo sapiens_hsa052191.74900972
20Biosynthesis of amino acids_Homo sapiens_hsa012301.73035105
21Non-small cell lung cancer_Homo sapiens_hsa052231.69324076
22RNA degradation_Homo sapiens_hsa030181.67915351
23Pentose phosphate pathway_Homo sapiens_hsa000301.63654767
24Other glycan degradation_Homo sapiens_hsa005111.57531080
25Legionellosis_Homo sapiens_hsa051341.55417583
26p53 signaling pathway_Homo sapiens_hsa041151.55035629
27B cell receptor signaling pathway_Homo sapiens_hsa046621.48214726
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47795478
29Pyrimidine metabolism_Homo sapiens_hsa002401.47421801
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42001179
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.39031915
32Graft-versus-host disease_Homo sapiens_hsa053321.37624535
33Herpes simplex infection_Homo sapiens_hsa051681.32978663
34Measles_Homo sapiens_hsa051621.29441670
35Allograft rejection_Homo sapiens_hsa053301.25732942
36Epstein-Barr virus infection_Homo sapiens_hsa051691.24438027
37Prion diseases_Homo sapiens_hsa050201.19649425
38Renal cell carcinoma_Homo sapiens_hsa052111.19163373
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.18439040
40Primary immunodeficiency_Homo sapiens_hsa053401.18182850
41Osteoclast differentiation_Homo sapiens_hsa043801.16732239
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15620163
43VEGF signaling pathway_Homo sapiens_hsa043701.14891160
44Carbon metabolism_Homo sapiens_hsa012001.13465270
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10263671
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08249850
47ErbB signaling pathway_Homo sapiens_hsa040121.07513825
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05368528
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.03648082
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.02604892
51Insulin signaling pathway_Homo sapiens_hsa049101.00162613
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97373914
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96317075
54Hippo signaling pathway_Homo sapiens_hsa043900.94516372
55Influenza A_Homo sapiens_hsa051640.94435817
56Adherens junction_Homo sapiens_hsa045200.93937200
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.93657022
58Glioma_Homo sapiens_hsa052140.91597641
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91185177
60Endocytosis_Homo sapiens_hsa041440.90982261
61Shigellosis_Homo sapiens_hsa051310.90267859
62TGF-beta signaling pathway_Homo sapiens_hsa043500.90211900
63Thyroid cancer_Homo sapiens_hsa052160.89691550
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88422447
65Viral carcinogenesis_Homo sapiens_hsa052030.88333120
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88313754
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88206047
68Autoimmune thyroid disease_Homo sapiens_hsa053200.86317899
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86312356
70Notch signaling pathway_Homo sapiens_hsa043300.85970242
71Protein export_Homo sapiens_hsa030600.85808927
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84558930
73Choline metabolism in cancer_Homo sapiens_hsa052310.82606330
74Leishmaniasis_Homo sapiens_hsa051400.81957842
75HTLV-I infection_Homo sapiens_hsa051660.81657946
76Inositol phosphate metabolism_Homo sapiens_hsa005620.81267519
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81098324
78Antigen processing and presentation_Homo sapiens_hsa046120.80693086
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.80276213
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79698250
81Purine metabolism_Homo sapiens_hsa002300.78328344
82Type I diabetes mellitus_Homo sapiens_hsa049400.77453305
83Proteoglycans in cancer_Homo sapiens_hsa052050.76144300
84Apoptosis_Homo sapiens_hsa042100.75954606
85HIF-1 signaling pathway_Homo sapiens_hsa040660.73872123
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73555414
87Prolactin signaling pathway_Homo sapiens_hsa049170.73253725
88Hepatitis B_Homo sapiens_hsa051610.72481970
89AMPK signaling pathway_Homo sapiens_hsa041520.71972563
90MicroRNAs in cancer_Homo sapiens_hsa052060.71011449
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.70490879
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69552381
93T cell receptor signaling pathway_Homo sapiens_hsa046600.69166636
94Phagosome_Homo sapiens_hsa041450.68990141
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66964789
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66647504
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66272763
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64678372
99Vibrio cholerae infection_Homo sapiens_hsa051100.64409135
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64001694
101Estrogen signaling pathway_Homo sapiens_hsa049150.63930399
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62652703
103Sulfur relay system_Homo sapiens_hsa041220.62272276
104Fatty acid biosynthesis_Homo sapiens_hsa000610.62182563
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62107053
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.62074492
107Viral myocarditis_Homo sapiens_hsa054160.60904047
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60203183
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59987563
110Arachidonic acid metabolism_Homo sapiens_hsa005900.59451448
111Galactose metabolism_Homo sapiens_hsa000520.59116860
112Chemokine signaling pathway_Homo sapiens_hsa040620.58829194
113TNF signaling pathway_Homo sapiens_hsa046680.58787891
114Acute myeloid leukemia_Homo sapiens_hsa052210.57347003
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57118273
116Hedgehog signaling pathway_Homo sapiens_hsa043400.54722013
117Asthma_Homo sapiens_hsa053100.54525196
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54096622
119Lysine degradation_Homo sapiens_hsa003100.53752408
120FoxO signaling pathway_Homo sapiens_hsa040680.52973360
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52249505
122Rheumatoid arthritis_Homo sapiens_hsa053230.51495747
123Prostate cancer_Homo sapiens_hsa052150.51264008
124Small cell lung cancer_Homo sapiens_hsa052220.51013337
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50189857
126Colorectal cancer_Homo sapiens_hsa052100.50035119
127Chronic myeloid leukemia_Homo sapiens_hsa052200.49512694
128Hematopoietic cell lineage_Homo sapiens_hsa046400.48934319
129Basal cell carcinoma_Homo sapiens_hsa052170.48783520
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47496545
131Fructose and mannose metabolism_Homo sapiens_hsa000510.47256709
132Endometrial cancer_Homo sapiens_hsa052130.46037948
133Melanoma_Homo sapiens_hsa052180.45214342
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44461238
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.42268229
136mTOR signaling pathway_Homo sapiens_hsa041500.41585966
137Oocyte meiosis_Homo sapiens_hsa041140.41384272
138Circadian rhythm_Homo sapiens_hsa047100.41324271
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37503883
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34000157
141Salmonella infection_Homo sapiens_hsa051320.32564901
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31317885
143Pathways in cancer_Homo sapiens_hsa052000.31316861
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30651453
145Tuberculosis_Homo sapiens_hsa051520.29673768
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29308430
147Wnt signaling pathway_Homo sapiens_hsa043100.29287884
148Hepatitis C_Homo sapiens_hsa051600.29210792
149Toxoplasmosis_Homo sapiens_hsa051450.28704158
150Pancreatic cancer_Homo sapiens_hsa052120.28167699
151Malaria_Homo sapiens_hsa051440.27890120
152N-Glycan biosynthesis_Homo sapiens_hsa005100.27401923

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