POLD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.46217691
2DNA unwinding involved in DNA replication (GO:0006268)5.27587572
3ribosomal small subunit assembly (GO:0000028)5.27025854
4* DNA strand elongation (GO:0022616)5.19992184
5* telomere maintenance via semi-conservative replication (GO:0032201)5.10731535
6DNA replication initiation (GO:0006270)5.06755034
7DNA deamination (GO:0045006)4.88105913
8viral transcription (GO:0019083)4.62478828
9translational termination (GO:0006415)4.52354110
10maturation of SSU-rRNA (GO:0030490)4.46727812
11nucleobase biosynthetic process (GO:0046112)4.41201667
12* telomere maintenance via recombination (GO:0000722)4.38928524
13protein maturation by protein folding (GO:0022417)4.35161414
14formation of translation preinitiation complex (GO:0001731)4.33446020
15folic acid-containing compound biosynthetic process (GO:0009396)4.25541708
16IMP biosynthetic process (GO:0006188)4.21463585
17translational elongation (GO:0006414)4.20158055
18* mitotic recombination (GO:0006312)4.17048709
19ribosomal small subunit biogenesis (GO:0042274)4.16419071
20protein localization to kinetochore (GO:0034501)4.13633031
21DNA replication checkpoint (GO:0000076)4.10722572
22L-serine metabolic process (GO:0006563)4.09604175
23regulation of mitochondrial translation (GO:0070129)4.07846653
24proline biosynthetic process (GO:0006561)4.06905374
25* telomere maintenance via telomere lengthening (GO:0010833)3.99436114
26translational initiation (GO:0006413)3.94179385
27ribosomal large subunit biogenesis (GO:0042273)3.92958898
28purine nucleobase biosynthetic process (GO:0009113)3.92537306
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90323381
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81616605
31mitotic nuclear envelope disassembly (GO:0007077)3.80174630
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78548892
33protein targeting to ER (GO:0045047)3.78188450
34cotranslational protein targeting to membrane (GO:0006613)3.78124655
35ribonucleoprotein complex biogenesis (GO:0022613)3.77584143
36IMP metabolic process (GO:0046040)3.77030795
37nucleobase-containing small molecule interconversion (GO:0015949)3.76967638
38* nucleotide-excision repair, DNA gap filling (GO:0006297)3.74642532
39establishment of viral latency (GO:0019043)3.74075600
40DNA replication-dependent nucleosome assembly (GO:0006335)3.68748098
41DNA replication-dependent nucleosome organization (GO:0034723)3.68748098
42ribosome biogenesis (GO:0042254)3.65942058
43protein localization to chromosome, centromeric region (GO:0071459)3.61374530
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60911207
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58490359
46cellular protein complex disassembly (GO:0043624)3.55394925
47protein localization to endoplasmic reticulum (GO:0070972)3.54299621
48viral life cycle (GO:0019058)3.52841096
49membrane disassembly (GO:0030397)3.47634363
50nuclear envelope disassembly (GO:0051081)3.47634363
51chromatin remodeling at centromere (GO:0031055)3.46251485
52CENP-A containing nucleosome assembly (GO:0034080)3.45681414
53pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.45060121
54peptidyl-arginine omega-N-methylation (GO:0035247)3.44520395
55Golgi transport vesicle coating (GO:0048200)3.43117714
56COPI coating of Golgi vesicle (GO:0048205)3.43117714
57rRNA processing (GO:0006364)3.43101455
58mitotic metaphase plate congression (GO:0007080)3.37948059
59spliceosomal snRNP assembly (GO:0000387)3.33871976
60guanosine-containing compound biosynthetic process (GO:1901070)3.33843974
61pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.33169123
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32947588
63negative regulation of ligase activity (GO:0051352)3.32947588
64DNA duplex unwinding (GO:0032508)3.32873047
65DNA geometric change (GO:0032392)3.31012967
66rRNA metabolic process (GO:0016072)3.30444174
67oxidative phosphorylation (GO:0006119)3.29807213
68ribosome assembly (GO:0042255)3.29514742
69protein complex disassembly (GO:0043241)3.29015373
70establishment of integrated proviral latency (GO:0075713)3.28999911
71mitotic nuclear envelope reassembly (GO:0007084)3.28626722
72nuclear envelope reassembly (GO:0031468)3.28626722
73pseudouridine synthesis (GO:0001522)3.28434585
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27566279
75tRNA aminoacylation for protein translation (GO:0006418)3.21446074
76DNA replication-independent nucleosome organization (GO:0034724)3.20093349
77DNA replication-independent nucleosome assembly (GO:0006336)3.20093349
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19380706
79nuclear pore organization (GO:0006999)3.19174746
80mitotic sister chromatid segregation (GO:0000070)3.16245895
81GDP-mannose metabolic process (GO:0019673)3.16100375
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.14903754
83UTP biosynthetic process (GO:0006228)3.14794195
84translation (GO:0006412)3.13496697
85tRNA aminoacylation (GO:0043039)3.11374580
86amino acid activation (GO:0043038)3.11374580
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11077838
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.11077838
89macromolecular complex disassembly (GO:0032984)3.10779485
90nuclear-transcribed mRNA catabolic process (GO:0000956)3.10714597
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07359700
92protein targeting to mitochondrion (GO:0006626)3.07123861
93regulation of mitotic spindle organization (GO:0060236)3.06898572
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06174854
95histone arginine methylation (GO:0034969)3.04232800
96translesion synthesis (GO:0019985)3.02459137
97* telomere organization (GO:0032200)3.00786177
98regulation of cellular amino acid metabolic process (GO:0006521)3.00748648
99* transcription-coupled nucleotide-excision repair (GO:0006283)3.00558001
100metaphase plate congression (GO:0051310)2.99894789
101* telomere maintenance (GO:0000723)2.99852689
102attachment of spindle microtubules to kinetochore (GO:0008608)2.96752868
103pentose-phosphate shunt (GO:0006098)2.95856908
104RNA catabolic process (GO:0006401)2.95161021
105mRNA catabolic process (GO:0006402)2.94644715
106cell cycle G1/S phase transition (GO:0044843)2.94339322
107G1/S transition of mitotic cell cycle (GO:0000082)2.94339322
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93797549
109negative regulation of RNA splicing (GO:0033119)2.93121307
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92406186
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.92179365
112kinetochore organization (GO:0051383)2.92177063
113mitotic chromosome condensation (GO:0007076)2.91978691
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91976212
115serine family amino acid biosynthetic process (GO:0009070)2.91017833
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90955416
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.90955416
118proteasome assembly (GO:0043248)2.90577811
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90163339
120pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89831712
121CTP metabolic process (GO:0046036)2.88988048
122CTP biosynthetic process (GO:0006241)2.88988048
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88451915
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88451915
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.88436093
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87353265
127pteridine-containing compound biosynthetic process (GO:0042559)2.86685378
128mismatch repair (GO:0006298)2.86612281
129sister chromatid segregation (GO:0000819)2.86428254
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86338317
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86338317
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86338317
133folic acid metabolic process (GO:0046655)2.85558154
134nuclear pore complex assembly (GO:0051292)2.85368931
135signal transduction involved in cell cycle checkpoint (GO:0072395)2.83983504
136deoxyribonucleotide biosynthetic process (GO:0009263)2.83797169
137postreplication repair (GO:0006301)2.83597502
1382-deoxyribonucleotide biosynthetic process (GO:0009265)2.83255107
139deoxyribose phosphate biosynthetic process (GO:0046385)2.83255107
140regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83136250
141RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82889032
142mRNA splicing, via spliceosome (GO:0000398)2.82889032
143cellular component biogenesis (GO:0044085)2.82510929
144viral mRNA export from host cell nucleus (GO:0046784)2.81723900
145regulation of translational fidelity (GO:0006450)2.81717114
146RNA splicing, via transesterification reactions (GO:0000375)2.81617371
147UTP metabolic process (GO:0046051)2.80775679
148regulation of spindle organization (GO:0090224)2.80674103
149spliceosomal complex assembly (GO:0000245)2.80464816
150histone exchange (GO:0043486)2.80305668
151maturation of 5.8S rRNA (GO:0000460)2.79707762
152proline metabolic process (GO:0006560)2.79301937
153pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.78635001
154* base-excision repair (GO:0006284)2.78574091
155positive regulation of ligase activity (GO:0051351)2.78311776
156GTP biosynthetic process (GO:0006183)2.78071149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57503783
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.32058144
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07153729
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.48076863
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32768848
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97973898
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89816584
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84029708
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79033807
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.78516132
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75111552
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.65575346
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64653115
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.50288166
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44341147
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41099934
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36266596
18XRN2_22483619_ChIP-Seq_HELA_Human2.35881607
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19852218
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09330882
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08262426
22VDR_23849224_ChIP-Seq_CD4+_Human2.01155669
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99420576
24MYC_22102868_ChIP-Seq_BL_Human1.93896986
25FOXP3_21729870_ChIP-Seq_TREG_Human1.88392216
26DCP1A_22483619_ChIP-Seq_HELA_Human1.86528333
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86268174
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85450444
29ZNF263_19887448_ChIP-Seq_K562_Human1.85226651
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85044519
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.84886144
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82959292
33GABP_19822575_ChIP-Seq_HepG2_Human1.82332712
34AR_21909140_ChIP-Seq_LNCAP_Human1.81903970
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80723518
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80522366
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78631817
38CIITA_25753668_ChIP-Seq_RAJI_Human1.77131581
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.76137795
40TTF2_22483619_ChIP-Seq_HELA_Human1.73896136
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70802916
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70769171
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62683268
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60757425
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.56448516
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55854670
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51593867
48* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45368033
49VDR_21846776_ChIP-Seq_THP-1_Human1.44598021
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42973140
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39853124
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38648603
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38167219
54KDM5A_27292631_Chip-Seq_BREAST_Human1.38013650
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35462454
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34658872
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34377020
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.34358089
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33685499
60* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30900266
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30657708
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29096230
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27048516
64ELK1_19687146_ChIP-ChIP_HELA_Human1.25908766
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21130589
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20135253
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19510622
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19453279
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18914660
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18384283
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16586318
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15023170
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14988099
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12890247
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12784476
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11625935
77TFEB_21752829_ChIP-Seq_HELA_Human1.11420612
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09660072
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09559575
80* LXR_22292898_ChIP-Seq_THP-1_Human1.09253422
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.08980309
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07540287
83* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06690073
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06247876
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06043275
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06018192
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05824859
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05403737
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04249934
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.03561083
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02521152
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.01543062
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00191555
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00096655
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99803662
96RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98638760
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98589205
98P68_20966046_ChIP-Seq_HELA_Human0.98324568
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98311662
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.97509828
101SPI1_23547873_ChIP-Seq_NB4_Human0.94869392
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.94185701
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92294304
104ATF3_27146783_Chip-Seq_COLON_Human0.91217731
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90824081
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89486365
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88709964
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86754187
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86510076
110* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86087904
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84467730
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83529092
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82852962
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82662275
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82172527
116MYC_18940864_ChIP-ChIP_HL60_Human0.82028718
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82027682
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81275996
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79010434
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.78012238
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.77340139
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77179723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18876452
2MP0010094_abnormal_chromosome_stability4.57836519
3MP0004957_abnormal_blastocyst_morpholog4.42202188
4MP0003111_abnormal_nucleus_morphology4.31931578
5MP0008057_abnormal_DNA_replication3.90672204
6MP0003077_abnormal_cell_cycle3.88467833
7MP0008058_abnormal_DNA_repair3.03848874
8MP0002396_abnormal_hematopoietic_system2.99538877
9MP0008007_abnormal_cellular_replicative2.84253294
10MP0010352_gastrointestinal_tract_polyps2.64183594
11MP0008932_abnormal_embryonic_tissue2.57870429
12MP0002877_abnormal_melanocyte_morpholog2.37445803
13MP0001730_embryonic_growth_arrest2.29993605
14MP0003123_paternal_imprinting2.20694252
15MP0000350_abnormal_cell_proliferation2.18949222
16MP0000490_abnormal_crypts_of2.09918963
17MP0005451_abnormal_body_composition2.01355489
18MP0004233_abnormal_muscle_weight2.00768422
19MP0003786_premature_aging1.95202885
20MP0003806_abnormal_nucleotide_metabolis1.93089935
21MP0009697_abnormal_copulation1.88414002
22MP0010307_abnormal_tumor_latency1.75866607
23MP0001697_abnormal_embryo_size1.70128310
24MP0003763_abnormal_thymus_physiology1.69151436
25MP0008877_abnormal_DNA_methylation1.68904247
26MP0004808_abnormal_hematopoietic_stem1.67145272
27MP0002080_prenatal_lethality1.65318409
28MP0002234_abnormal_pharynx_morphology1.64504220
29MP0005380_embryogenesis_phenotype1.63696308
30MP0001672_abnormal_embryogenesis/_devel1.63696308
31MP0002019_abnormal_tumor_incidence1.61890102
32MP0001661_extended_life_span1.60017880
33MP0009333_abnormal_splenocyte_physiolog1.57428161
34MP0005501_abnormal_skin_physiology1.53884292
35MP0000313_abnormal_cell_death1.53658722
36MP0003984_embryonic_growth_retardation1.51587985
37MP0000372_irregular_coat_pigmentation1.49372048
38MP0001545_abnormal_hematopoietic_system1.48072157
39MP0005397_hematopoietic_system_phenotyp1.48072157
40MP0002088_abnormal_embryonic_growth/wei1.47545811
41MP0003567_abnormal_fetal_cardiomyocyte1.43625350
42MP0002085_abnormal_embryonic_tissue1.42757167
43MP0004185_abnormal_adipocyte_glucose1.33193592
44MP0002086_abnormal_extraembryonic_tissu1.33037620
45MP0004197_abnormal_fetal_growth/weight/1.32021697
46MP0000703_abnormal_thymus_morphology1.29919608
47MP0002398_abnormal_bone_marrow1.28686578
48MP0010030_abnormal_orbit_morphology1.28211310
49MP0002722_abnormal_immune_system1.26590590
50MP0002084_abnormal_developmental_patter1.25595792
51MP0004858_abnormal_nervous_system1.25466103
52MP0002249_abnormal_larynx_morphology1.25350237
53MP0000689_abnormal_spleen_morphology1.21587181
54MP0005171_absent_coat_pigmentation1.21456214
55MP0005408_hypopigmentation1.20819327
56MP0006054_spinal_hemorrhage1.18400965
57MP0010234_abnormal_vibrissa_follicle1.12255378
58MP0008260_abnormal_autophagy1.12172407
59MP0002938_white_spotting1.11061739
60MP0000358_abnormal_cell_content/1.10550973
61MP0000858_altered_metastatic_potential1.10458157
62MP0003315_abnormal_perineum_morphology1.06777493
63MP0005330_cardiomyopathy1.05277946
64MP0002429_abnormal_blood_cell1.04790826
65MP0005670_abnormal_white_adipose1.03726726
66MP0009053_abnormal_anal_canal1.01807268
67MP0003121_genomic_imprinting1.00621950
68MP0002796_impaired_skin_barrier1.00594678
69MP0003186_abnormal_redox_activity0.99517010
70MP0005076_abnormal_cell_differentiation0.99124862
71MP0003718_maternal_effect0.98758325
72MP0006036_abnormal_mitochondrial_physio0.98735377
73MP0000003_abnormal_adipose_tissue0.98554821
74MP0001346_abnormal_lacrimal_gland0.98461338
75MP0001853_heart_inflammation0.97208065
76MP0000566_synostosis0.96443481
77MP0000751_myopathy0.95731108
78MP0002132_abnormal_respiratory_system0.95297693
79MP0009278_abnormal_bone_marrow0.95025077
80MP0005623_abnormal_meninges_morphology0.94445933
81MP0005058_abnormal_lysosome_morphology0.94071186
82MP0003221_abnormal_cardiomyocyte_apopto0.93774883
83MP0004133_heterotaxia0.92144860
84MP0005023_abnormal_wound_healing0.91892695
85MP0001881_abnormal_mammary_gland0.91855056
86MP0001293_anophthalmia0.90809469
87MP0003385_abnormal_body_wall0.90771552
88MP0002210_abnormal_sex_determination0.90607533
89MP0000747_muscle_weakness0.90419471
90MP0005075_abnormal_melanosome_morpholog0.90287505
91MP0008789_abnormal_olfactory_epithelium0.89977706
92MP0000762_abnormal_tongue_morphology0.88049520
93MP0000685_abnormal_immune_system0.87646714
94MP0000716_abnormal_immune_system0.87627589
95MP0001145_abnormal_male_reproductive0.86926894
96MP0000477_abnormal_intestine_morphology0.86013265
97MP0002060_abnormal_skin_morphology0.82464035
98MP0001529_abnormal_vocalization0.79939141
99MP0002653_abnormal_ependyma_morphology0.79639584
100MP0003119_abnormal_digestive_system0.79322358
101MP0000049_abnormal_middle_ear0.77840522
102MP0002697_abnormal_eye_size0.77824589
103MP0003942_abnormal_urinary_system0.76558343
104MP0001727_abnormal_embryo_implantation0.75786534
105MP0006035_abnormal_mitochondrial_morpho0.75720261
106MP0005384_cellular_phenotype0.75574692
107MP0005266_abnormal_metabolism0.75403397
108MP0000537_abnormal_urethra_morphology0.75095543
109MP0002160_abnormal_reproductive_system0.74737035
110MP0001764_abnormal_homeostasis0.73546389
111MP0005499_abnormal_olfactory_system0.73387007
112MP0005394_taste/olfaction_phenotype0.73387007
113MP0001873_stomach_inflammation0.72937054
114MP0009379_abnormal_foot_pigmentation0.72851693
115MP0005257_abnormal_intraocular_pressure0.71108232
116MP0000627_abnormal_mammary_gland0.70847658
117MP0001929_abnormal_gametogenesis0.70678833
118MP0001915_intracranial_hemorrhage0.69416556
119MP0000653_abnormal_sex_gland0.69098479
120MP0004264_abnormal_extraembryonic_tissu0.69054775
121MP0000749_muscle_degeneration0.68451283
122MP0000681_abnormal_thyroid_gland0.67956667
123MP0003705_abnormal_hypodermis_morpholog0.67440488
124MP0000759_abnormal_skeletal_muscle0.67127851
125MP0002970_abnormal_white_adipose0.66978246
126MP0010155_abnormal_intestine_physiology0.66504821
127MP0002420_abnormal_adaptive_immunity0.66472269
128MP0010771_integument_phenotype0.66212150
129MP0002111_abnormal_tail_morphology0.66020052
130MP0002405_respiratory_system_inflammati0.66004822
131MP0001800_abnormal_humoral_immune0.65586126
132MP0001819_abnormal_immune_cell0.64828401
133MP0009672_abnormal_birth_weight0.64744625
134MP0002269_muscular_atrophy0.63712751
135MP0005621_abnormal_cell_physiology0.62718609
136MP0001835_abnormal_antigen_presentation0.62586354
137MP0001849_ear_inflammation0.61106724
138MP0003566_abnormal_cell_adhesion0.60646974
139MP0003890_abnormal_embryonic-extraembry0.60447374
140MP0005671_abnormal_response_to0.60402408
141MP0002452_abnormal_antigen_presenting0.56965774
142MP0000750_abnormal_muscle_regeneration0.56910820
143MP0003866_abnormal_defecation0.56532201
144MP0000678_abnormal_parathyroid_gland0.56353080
145MP0001119_abnormal_female_reproductive0.56176480
146MP0000465_gastrointestinal_hemorrhage0.54844450
147MP0006292_abnormal_olfactory_placode0.54594728

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.13232589
2Abnormal number of erythroid precursors (HP:0012131)4.95255367
3Reticulocytopenia (HP:0001896)4.92091573
4Birth length less than 3rd percentile (HP:0003561)4.48155415
5Abnormality of glycolysis (HP:0004366)4.31480100
6Abnormal gallbladder physiology (HP:0012438)3.94831673
7Cholecystitis (HP:0001082)3.94831673
8Oral leukoplakia (HP:0002745)3.93145789
9Selective tooth agenesis (HP:0001592)3.83914873
10Increased serum pyruvate (HP:0003542)3.81484464
11Aplastic anemia (HP:0001915)3.79739296
12Abnormal mitochondria in muscle tissue (HP:0008316)3.71886411
13Colon cancer (HP:0003003)3.65825206
14Microvesicular hepatic steatosis (HP:0001414)3.64091002
15Acute necrotizing encephalopathy (HP:0006965)3.33955429
16Acute encephalopathy (HP:0006846)3.29235866
17Breast hypoplasia (HP:0003187)3.26122147
18Pallor (HP:0000980)3.21225517
19Hepatocellular necrosis (HP:0001404)3.20001007
20Medulloblastoma (HP:0002885)3.15251565
21Macrocytic anemia (HP:0001972)3.14304373
22Ependymoma (HP:0002888)3.13065728
23Chromsome breakage (HP:0040012)3.11481112
24Degeneration of anterior horn cells (HP:0002398)3.09072969
25Abnormality of the anterior horn cell (HP:0006802)3.09072969
26Hepatic necrosis (HP:0002605)2.98218983
27Microretrognathia (HP:0000308)2.96760837
28Multiple enchondromatosis (HP:0005701)2.93784420
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88886394
30Rough bone trabeculation (HP:0100670)2.88340984
31Mitochondrial inheritance (HP:0001427)2.87410658
32Testicular atrophy (HP:0000029)2.83319196
33Increased CSF lactate (HP:0002490)2.82170347
34Absent thumb (HP:0009777)2.77910907
35Patellar aplasia (HP:0006443)2.77260943
36Thrombocytosis (HP:0001894)2.77023543
37Trismus (HP:0000211)2.70331389
38Carpal bone hypoplasia (HP:0001498)2.66169207
39Cerebral edema (HP:0002181)2.66077062
40Abnormality of chromosome stability (HP:0003220)2.66000850
41Progressive muscle weakness (HP:0003323)2.64605973
4211 pairs of ribs (HP:0000878)2.64163339
43Meckel diverticulum (HP:0002245)2.63292300
44Aplasia/Hypoplasia of the patella (HP:0006498)2.58948666
45Abnormality of the preputium (HP:0100587)2.58945211
46Exercise intolerance (HP:0003546)2.57824922
47Agnosia (HP:0010524)2.57521589
48Truncus arteriosus (HP:0001660)2.57450706
49Abnormality of the ileum (HP:0001549)2.56441258
50Myelodysplasia (HP:0002863)2.55627702
51Abnormal number of incisors (HP:0011064)2.54730723
52Basal cell carcinoma (HP:0002671)2.54533133
53Neoplasm of the pancreas (HP:0002894)2.48428459
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48245283
55Premature graying of hair (HP:0002216)2.47417769
56Increased intramyocellular lipid droplets (HP:0012240)2.47063414
57Lactic acidosis (HP:0003128)2.44236600
58Progressive macrocephaly (HP:0004481)2.43798499
59Type I transferrin isoform profile (HP:0003642)2.39286034
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36824093
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36824093
62Cerebral hypomyelination (HP:0006808)2.34787528
63Rhabdomyosarcoma (HP:0002859)2.31491218
64IgM deficiency (HP:0002850)2.31403390
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31299226
66Abnormal protein N-linked glycosylation (HP:0012347)2.31299226
67Abnormal protein glycosylation (HP:0012346)2.31299226
68Abnormal glycosylation (HP:0012345)2.31299226
69Hypokinesia (HP:0002375)2.30959879
70Hyperacusis (HP:0010780)2.30380203
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.30345239
72Abnormality of the umbilical cord (HP:0010881)2.29239846
73Hyperthyroidism (HP:0000836)2.27267605
74Bone marrow hypocellularity (HP:0005528)2.26580688
75Pancytopenia (HP:0001876)2.24096878
76Increased muscle lipid content (HP:0009058)2.22138315
77Duodenal stenosis (HP:0100867)2.18841537
78Small intestinal stenosis (HP:0012848)2.18841537
79Abnormality of reticulocytes (HP:0004312)2.18248693
80Cholelithiasis (HP:0001081)2.17411151
81Squamous cell carcinoma (HP:0002860)2.16620925
82Missing ribs (HP:0000921)2.15862947
83Lymphoma (HP:0002665)2.14469501
84Broad distal phalanx of finger (HP:0009836)2.12371332
85Reduced antithrombin III activity (HP:0001976)2.12119292
86Insomnia (HP:0100785)2.09861591
87Slender long bone (HP:0003100)2.09035478
88Tracheoesophageal fistula (HP:0002575)2.08733973
89Absent radius (HP:0003974)2.07894014
90Abnormal lung lobation (HP:0002101)2.07856963
91Cleft eyelid (HP:0000625)2.06354714
92Respiratory failure (HP:0002878)2.03718858
93Vertebral compression fractures (HP:0002953)2.03035023
94Absent epiphyses (HP:0010577)2.02464584
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02464584
96Hypoplasia of the pons (HP:0012110)2.01878610
97Atresia of the external auditory canal (HP:0000413)2.00030441
98Sloping forehead (HP:0000340)1.99741059
99Abnormality of pyrimidine metabolism (HP:0004353)1.97857962
100Increased nuchal translucency (HP:0010880)1.96790067
101Abnormality of the distal phalanges of the toes (HP:0010182)1.94561768
102Facial cleft (HP:0002006)1.94474485
103Amaurosis fugax (HP:0100576)1.94138033
104Increased serum lactate (HP:0002151)1.94132156
105Secondary amenorrhea (HP:0000869)1.93249815
106Cellular immunodeficiency (HP:0005374)1.93046742
107Achilles tendon contracture (HP:0001771)1.92765262
108Aplasia involving forearm bones (HP:0009822)1.92405815
109Absent forearm bone (HP:0003953)1.92405815
110Abnormal trabecular bone morphology (HP:0100671)1.91371771
111Spastic paraparesis (HP:0002313)1.90281081
112High pitched voice (HP:0001620)1.90081315
113Proximal placement of thumb (HP:0009623)1.89994570
114Entropion (HP:0000621)1.89773823
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89772087
116Abnormality of the calcaneus (HP:0008364)1.89620499
117Microglossia (HP:0000171)1.87641710
118Abnormal gallbladder morphology (HP:0012437)1.86458615
119Abnormalities of placenta or umbilical cord (HP:0001194)1.84123228
120Triphalangeal thumb (HP:0001199)1.82866368
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.82192014
122Abnormality of the duodenum (HP:0002246)1.82036403
123Ragged-red muscle fibers (HP:0003200)1.81642885
124Muscle fiber atrophy (HP:0100295)1.80939216
125Premature ovarian failure (HP:0008209)1.80904995
126Hypertensive crisis (HP:0100735)1.80592874
127Short nail (HP:0001799)1.80553747
128Emotional lability (HP:0000712)1.80537003
129Deviation of the thumb (HP:0009603)1.80485270
130Horseshoe kidney (HP:0000085)1.79924180
131Cafe-au-lait spot (HP:0000957)1.79738393
132Poor head control (HP:0002421)1.79715682
133Supernumerary spleens (HP:0009799)1.79629516
134Glossoptosis (HP:0000162)1.79143608
135Glioma (HP:0009733)1.79014124
136Abnormality of the pons (HP:0007361)1.78771408
137Abnormality of the astrocytes (HP:0100707)1.78677868
138Astrocytoma (HP:0009592)1.78677868
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.78299285
140Asplenia (HP:0001746)1.77782836
141Neoplasm of striated muscle (HP:0009728)1.77762170
142Reduced subcutaneous adipose tissue (HP:0003758)1.77611183
143Impulsivity (HP:0100710)1.77527820
144Neoplasm of the colon (HP:0100273)1.77247410
145Prominent nose (HP:0000448)1.76138706
146Sparse eyelashes (HP:0000653)1.75814065
147Increased hepatocellular lipid droplets (HP:0006565)1.75787929
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75005994
149Abnormality of the gallbladder (HP:0005264)1.74870214
150Cutaneous melanoma (HP:0012056)1.74629221
151Opisthotonus (HP:0002179)1.74506219
152Upper limb muscle weakness (HP:0003484)1.74199081
153Hypergonadotropic hypogonadism (HP:0000815)1.74008267
154Abnormality of T cell physiology (HP:0011840)1.73624309
155Redundant skin (HP:0001582)1.70766381
156Hypoplasia of the radius (HP:0002984)1.70422228
157Abnormality of the tricuspid valve (HP:0001702)1.69680801
158Overriding aorta (HP:0002623)1.67009142
159Myopathic facies (HP:0002058)1.65680471
160Abnormality of subcutaneous fat tissue (HP:0001001)1.64898511
161Lipid accumulation in hepatocytes (HP:0006561)1.64602042
162Patellar dislocation (HP:0002999)1.64582464
163Poikiloderma (HP:0001029)1.61946547
164Leukodystrophy (HP:0002415)1.61945138
165Abnormality of the Achilles tendon (HP:0005109)1.61695295
166Breech presentation (HP:0001623)1.60161940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.81517355
2WEE14.17338791
3BUB14.10498367
4CDC74.07181542
5SMG13.25181695
6NME22.83133606
7EIF2AK12.75522632
8PASK2.50406281
9EEF2K2.44905197
10NEK12.41544399
11NEK22.38946721
12PBK2.30100399
13TTK2.22227922
14TESK22.17655669
15IRAK32.14699562
16TSSK62.05127569
17EIF2AK31.94796426
18ACVR1B1.89038850
19SCYL21.86529075
20STK161.84796178
21RPS6KB21.82542030
22CDK71.79795093
23PLK11.73893726
24SRPK11.72946423
25VRK11.72207501
26MST1R1.67325441
27TLK11.64572043
28ATR1.62410332
29MAP3K101.61858943
30ARAF1.61176039
31AURKB1.58177562
32BRSK21.57266972
33NME11.51585062
34CDK41.51290778
35ICK1.49478934
36FLT31.47166746
37TAF11.46370714
38PRKD31.46227579
39PKN21.45326795
40TGFBR11.43727333
41MAP4K11.42800404
42MAP3K81.38067543
43PAK41.36791812
44PLK41.32976995
45RPS6KA41.26308241
46MKNK11.24450617
47CHEK21.23672237
48KDR1.22876209
49PIM21.17868356
50AURKA1.17577788
51BRSK11.14463405
52STK101.12739371
53DYRK31.09712605
54MAP3K111.07215067
55BCKDK1.05846550
56LRRK21.04984729
57CHEK11.04143551
58CSNK1G31.03438164
59MAP2K31.01459879
60STK40.99875215
61PIM10.99465383
62TESK10.98113698
63CDK80.97990824
64PDK20.97548579
65CCNB10.96137172
66CLK10.93373906
67ABL20.92148995
68CDK120.91858415
69EPHA20.85519561
70PLK30.84248191
71CSNK1A1L0.83793197
72MKNK20.82249909
73MAPKAPK50.76297819
74SIK10.74511643
75CDK20.74380308
76MAPKAPK30.73636666
77BTK0.71629048
78LMTK20.71244687
79PRKCI0.69733291
80MET0.69208256
81NEK90.69077623
82CSNK2A20.68605918
83TRIB30.67619812
84ZAP700.66490461
85PAK10.66075858
86ATM0.65971036
87CSNK2A10.65260467
88CSNK1G10.62645692
89PTK20.60810075
90CDK60.60580525
91ZAK0.60136075
92ILK0.57970420
93RAF10.57697967
94ALK0.56901307
95CSNK1G20.53876402
96ERBB40.52796584
97CDK90.51337973
98GRK60.49467931
99ERN10.49336683
100CDK11A0.47578268
101BLK0.47569854
102CDK10.47210186
103CDK140.46610785
104CDK150.44158731
105TAOK20.43902286
106AKT20.42819267
107CDK180.42038600
108TEC0.41886470
109DAPK30.41706685
110MELK0.41425912
111CAMK2G0.40575711
112DYRK20.39774512
113EIF2AK20.39076327
114MTOR0.37300222
115MAP3K120.36696032
116JAK30.36682859
117BRAF0.35100286
118PAK20.34453432
119RPS6KA50.33460076
120DAPK10.31366201
121CSF1R0.30803041
122MAPK110.29211094
123PDK30.26461144
124PDK40.26461144
125LIMK10.25929551
126KIT0.25572768
127RPS6KC10.25087847
128RPS6KL10.25087847
129BRD40.24580518
130RPS6KA60.24141184
131PRKDC0.23098433
132MAP3K30.22003095

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.65478316
2* Mismatch repair_Homo sapiens_hsa034304.43889383
3Ribosome_Homo sapiens_hsa030104.01286726
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25029876
5Spliceosome_Homo sapiens_hsa030403.23789143
6* Base excision repair_Homo sapiens_hsa034103.20552093
7Proteasome_Homo sapiens_hsa030502.99287251
8One carbon pool by folate_Homo sapiens_hsa006702.95220454
9* Homologous recombination_Homo sapiens_hsa034402.89695723
10* Nucleotide excision repair_Homo sapiens_hsa034202.80453818
11RNA transport_Homo sapiens_hsa030132.79938029
12RNA polymerase_Homo sapiens_hsa030202.75102387
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68093830
14Cell cycle_Homo sapiens_hsa041102.54779866
15* Pyrimidine metabolism_Homo sapiens_hsa002402.46110095
16Fanconi anemia pathway_Homo sapiens_hsa034601.93371394
17Non-homologous end-joining_Homo sapiens_hsa034501.88280598
18Fatty acid elongation_Homo sapiens_hsa000621.80745687
19RNA degradation_Homo sapiens_hsa030181.74085679
20Vitamin B6 metabolism_Homo sapiens_hsa007501.55775932
21Basal transcription factors_Homo sapiens_hsa030221.45009405
22p53 signaling pathway_Homo sapiens_hsa041151.38577784
23mRNA surveillance pathway_Homo sapiens_hsa030151.36574701
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34635212
25Biosynthesis of amino acids_Homo sapiens_hsa012301.22803935
26* Purine metabolism_Homo sapiens_hsa002301.19601539
27Systemic lupus erythematosus_Homo sapiens_hsa053221.17758818
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15388354
29Sulfur relay system_Homo sapiens_hsa041221.13612167
30Pentose phosphate pathway_Homo sapiens_hsa000301.09653849
31Alzheimers disease_Homo sapiens_hsa050101.06268016
32Epstein-Barr virus infection_Homo sapiens_hsa051691.04276304
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02676342
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.01864722
35Folate biosynthesis_Homo sapiens_hsa007901.01806179
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01604778
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00765305
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.98980738
39Antigen processing and presentation_Homo sapiens_hsa046120.93267779
40Phenylalanine metabolism_Homo sapiens_hsa003600.92415585
41Steroid biosynthesis_Homo sapiens_hsa001000.92070207
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91397970
43Viral carcinogenesis_Homo sapiens_hsa052030.90748888
44Selenocompound metabolism_Homo sapiens_hsa004500.89865338
45Carbon metabolism_Homo sapiens_hsa012000.87097336
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85995154
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.85885943
48Herpes simplex infection_Homo sapiens_hsa051680.84637655
49Fatty acid metabolism_Homo sapiens_hsa012120.81800528
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78224112
51Primary immunodeficiency_Homo sapiens_hsa053400.74149391
52N-Glycan biosynthesis_Homo sapiens_hsa005100.72430551
53Sulfur metabolism_Homo sapiens_hsa009200.72057936
54* HTLV-I infection_Homo sapiens_hsa051660.68849671
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68486710
56Protein export_Homo sapiens_hsa030600.68423887
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63902000
58Tyrosine metabolism_Homo sapiens_hsa003500.63523635
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62144442
60Oocyte meiosis_Homo sapiens_hsa041140.62090131
61Legionellosis_Homo sapiens_hsa051340.60972951
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60862452
63Vibrio cholerae infection_Homo sapiens_hsa051100.60397047
64Arginine biosynthesis_Homo sapiens_hsa002200.58515739
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57813016
66Fructose and mannose metabolism_Homo sapiens_hsa000510.57458721
67Thyroid cancer_Homo sapiens_hsa052160.57293829
68Huntingtons disease_Homo sapiens_hsa050160.55822955
69Parkinsons disease_Homo sapiens_hsa050120.55437912
70Propanoate metabolism_Homo sapiens_hsa006400.55276221
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54580549
72Small cell lung cancer_Homo sapiens_hsa052220.52834114
73Galactose metabolism_Homo sapiens_hsa000520.52665387
74Lysine degradation_Homo sapiens_hsa003100.52453464
75Glutathione metabolism_Homo sapiens_hsa004800.51450734
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50446475
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49771601
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48326568
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47087760
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42900117
81Peroxisome_Homo sapiens_hsa041460.42865273
82Bladder cancer_Homo sapiens_hsa052190.42468778
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42328929
84Apoptosis_Homo sapiens_hsa042100.41674499
85Alcoholism_Homo sapiens_hsa050340.36535709
86Shigellosis_Homo sapiens_hsa051310.35889395
87MicroRNAs in cancer_Homo sapiens_hsa052060.35730860
88Measles_Homo sapiens_hsa051620.35643650
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35629988
90Chronic myeloid leukemia_Homo sapiens_hsa052200.33318782
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32988481
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.32341128
93Notch signaling pathway_Homo sapiens_hsa043300.31770502
94Colorectal cancer_Homo sapiens_hsa052100.30715329
95Hepatitis B_Homo sapiens_hsa051610.30193002
96Cardiac muscle contraction_Homo sapiens_hsa042600.28741845
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27964421
98HIF-1 signaling pathway_Homo sapiens_hsa040660.27109907
99* Metabolic pathways_Homo sapiens_hsa011000.26087484
100Acute myeloid leukemia_Homo sapiens_hsa052210.24604475
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24214190
102Other glycan degradation_Homo sapiens_hsa005110.24152982
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.23914165
104Arginine and proline metabolism_Homo sapiens_hsa003300.23504197
105Viral myocarditis_Homo sapiens_hsa054160.20721777
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19792482
107Oxidative phosphorylation_Homo sapiens_hsa001900.19115271
108Renin-angiotensin system_Homo sapiens_hsa046140.18723506
109Fatty acid degradation_Homo sapiens_hsa000710.17868326
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17693780
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17189156
112Pyruvate metabolism_Homo sapiens_hsa006200.16257109
113Hematopoietic cell lineage_Homo sapiens_hsa046400.15648065
114Basal cell carcinoma_Homo sapiens_hsa052170.15518815
115Influenza A_Homo sapiens_hsa051640.14865352
116Fatty acid biosynthesis_Homo sapiens_hsa000610.14443730
117Pancreatic cancer_Homo sapiens_hsa052120.13859026
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13309820
119Pathways in cancer_Homo sapiens_hsa052000.12929246
120beta-Alanine metabolism_Homo sapiens_hsa004100.12823246
121AMPK signaling pathway_Homo sapiens_hsa041520.12570644
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.11538545
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11126162
124Hippo signaling pathway_Homo sapiens_hsa043900.10956411
125TGF-beta signaling pathway_Homo sapiens_hsa043500.10843116
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10582118
127Non-small cell lung cancer_Homo sapiens_hsa052230.09912322
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08855986
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08532347

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