POLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.11905292
2* DNA strand elongation involved in DNA replication (GO:0006271)5.36546731
3DNA replication initiation (GO:0006270)5.14447925
4* DNA strand elongation (GO:0022616)5.08070215
5* telomere maintenance via semi-conservative replication (GO:0032201)4.79270383
6protein localization to kinetochore (GO:0034501)4.70192147
7DNA topological change (GO:0006265)4.29899425
8ribosomal small subunit assembly (GO:0000028)4.25966037
9* telomere maintenance via recombination (GO:0000722)4.15786229
10folic acid-containing compound biosynthetic process (GO:0009396)4.14842035
11DNA replication checkpoint (GO:0000076)4.11868536
12proline biosynthetic process (GO:0006561)4.06537238
13* mitotic recombination (GO:0006312)4.06152637
14DNA replication-dependent nucleosome assembly (GO:0006335)4.05564930
15DNA replication-dependent nucleosome organization (GO:0034723)4.05564930
16IMP biosynthetic process (GO:0006188)4.04038205
17formation of translation preinitiation complex (GO:0001731)4.03418765
18protein localization to chromosome, centromeric region (GO:0071459)4.02930589
19mitotic nuclear envelope disassembly (GO:0007077)4.01577840
20viral transcription (GO:0019083)3.94323214
21nucleobase biosynthetic process (GO:0046112)3.88978318
22DNA duplex unwinding (GO:0032508)3.88929241
23DNA geometric change (GO:0032392)3.86384611
24maturation of SSU-rRNA (GO:0030490)3.82619087
25mitotic sister chromatid segregation (GO:0000070)3.82232865
26translational termination (GO:0006415)3.82158976
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78972101
28* telomere maintenance via telomere lengthening (GO:0010833)3.74001784
29nuclear envelope disassembly (GO:0051081)3.70840355
30membrane disassembly (GO:0030397)3.70840355
31chromosome condensation (GO:0030261)3.64652067
32sister chromatid segregation (GO:0000819)3.61621649
33spliceosomal tri-snRNP complex assembly (GO:0000244)3.60267558
34regulation of histone H3-K9 methylation (GO:0051570)3.59953971
35* nucleotide-excision repair, DNA gap filling (GO:0006297)3.59536045
36negative regulation of RNA splicing (GO:0033119)3.59375520
37mitotic chromosome condensation (GO:0007076)3.58889414
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57087186
39pore complex assembly (GO:0046931)3.56800973
40nuclear pore organization (GO:0006999)3.56551549
41translational elongation (GO:0006414)3.54651636
42protein-DNA complex disassembly (GO:0032986)3.53599666
43nucleosome disassembly (GO:0006337)3.53599666
44IMP metabolic process (GO:0046040)3.53429997
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48237482
46translational initiation (GO:0006413)3.42699456
47nuclear pore complex assembly (GO:0051292)3.41388335
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40672532
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40222114
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.40222114
51folic acid metabolic process (GO:0046655)3.30862388
52ribosomal small subunit biogenesis (GO:0042274)3.30735826
53viral mRNA export from host cell nucleus (GO:0046784)3.30535086
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29368694
55negative regulation of mRNA processing (GO:0050686)3.28822420
56histone arginine methylation (GO:0034969)3.28809257
57mitotic metaphase plate congression (GO:0007080)3.27976928
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27769117
59DNA deamination (GO:0045006)3.27611658
60regulation of translational fidelity (GO:0006450)3.27271932
61protein complex localization (GO:0031503)3.26478557
62pentose-phosphate shunt (GO:0006098)3.26429050
63negative regulation of histone methylation (GO:0031061)3.25037913
64purine nucleobase biosynthetic process (GO:0009113)3.21781933
65heterochromatin organization (GO:0070828)3.20694311
66chromatin remodeling at centromere (GO:0031055)3.19501249
67kinetochore organization (GO:0051383)3.19304045
68CENP-A containing nucleosome assembly (GO:0034080)3.15696082
69DNA conformation change (GO:0071103)3.14085074
70L-serine metabolic process (GO:0006563)3.13870668
71ribosomal large subunit biogenesis (GO:0042273)3.13327176
72DNA replication-independent nucleosome organization (GO:0034724)3.13080556
73DNA replication-independent nucleosome assembly (GO:0006336)3.13080556
74dosage compensation (GO:0007549)3.11713850
75mitotic sister chromatid cohesion (GO:0007064)3.11635652
76chromatin assembly or disassembly (GO:0006333)3.10927222
77DNA packaging (GO:0006323)3.10634379
78nucleobase-containing small molecule interconversion (GO:0015949)3.09837847
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08859133
80regulation of sister chromatid cohesion (GO:0007063)3.08630169
81peptidyl-arginine N-methylation (GO:0035246)3.07335122
82peptidyl-arginine methylation (GO:0018216)3.07335122
83DNA ligation (GO:0006266)3.05754381
84positive regulation of chromosome segregation (GO:0051984)3.03914001
85establishment of integrated proviral latency (GO:0075713)3.03763118
86cellular protein complex disassembly (GO:0043624)3.02739303
87metaphase plate congression (GO:0051310)3.01858853
88ribonucleoprotein complex biogenesis (GO:0022613)3.01841564
89* telomere maintenance (GO:0000723)2.99874743
90* telomere organization (GO:0032200)2.99646495
91protein targeting to ER (GO:0045047)2.99213992
92cotranslational protein targeting to membrane (GO:0006613)2.98537877
93chromatin assembly (GO:0031497)2.98275014
94viral life cycle (GO:0019058)2.97921589
95RNA stabilization (GO:0043489)2.97359609
96mRNA stabilization (GO:0048255)2.97359609
97negative regulation of mRNA metabolic process (GO:1903312)2.97008196
98protein complex disassembly (GO:0043241)2.95399400
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94604113
100mRNA splicing, via spliceosome (GO:0000398)2.94604113
101establishment of viral latency (GO:0019043)2.94582183
102ribosome biogenesis (GO:0042254)2.94195995
103RNA splicing, via transesterification reactions (GO:0000375)2.92627731
1043-UTR-mediated mRNA stabilization (GO:0070935)2.92041587
105* base-excision repair (GO:0006284)2.91930108
106rRNA transcription (GO:0009303)2.91648889
107V(D)J recombination (GO:0033151)2.91005992
108protein localization to chromosome (GO:0034502)2.90140418
109nuclear envelope organization (GO:0006998)2.90092496
110mismatch repair (GO:0006298)2.90039243
111attachment of spindle microtubules to kinetochore (GO:0008608)2.88521283
112NADPH regeneration (GO:0006740)2.88423460
113regulation of spindle organization (GO:0090224)2.88087401
114negative regulation of erythrocyte differentiation (GO:0045647)2.85278840
115apoptotic process involved in morphogenesis (GO:0060561)2.84133725
116ATP-dependent chromatin remodeling (GO:0043044)2.83634313
117establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83572111
118peptidyl-arginine omega-N-methylation (GO:0035247)2.83526586
119termination of RNA polymerase II transcription (GO:0006369)2.83025469
120rRNA processing (GO:0006364)2.82708881
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.82007776
122nuclear-transcribed mRNA catabolic process (GO:0000956)2.81957851
123glucose catabolic process (GO:0006007)2.81278790
124spliceosomal snRNP assembly (GO:0000387)2.80018185
125COPI coating of Golgi vesicle (GO:0048205)2.79090816
126Golgi transport vesicle coating (GO:0048200)2.79090816
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.78112120
128establishment of chromosome localization (GO:0051303)2.77290189
129meiotic chromosome segregation (GO:0045132)2.77271706
130regulation of translational termination (GO:0006449)2.77225861
131kinetochore assembly (GO:0051382)2.76928340
132chromosome segregation (GO:0007059)2.76415142
133regulation of chromosome segregation (GO:0051983)2.76407932
134cellular protein complex localization (GO:0034629)2.76020448
135protein localization to endoplasmic reticulum (GO:0070972)2.75678654
136rRNA metabolic process (GO:0016072)2.74170137
137macromolecular complex disassembly (GO:0032984)2.74167012
138* translesion synthesis (GO:0019985)2.74166922
139regulation of RNA export from nucleus (GO:0046831)2.72714763
140nuclear envelope reassembly (GO:0031468)2.71988831
141mitotic nuclear envelope reassembly (GO:0007084)2.71988831
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67875649
143pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67624733
144mitochondrial DNA metabolic process (GO:0032042)2.66355428
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65300315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.89519352
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38290425
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73667399
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69663981
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65673167
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02515557
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77023630
8MYC_22102868_ChIP-Seq_BL_Human2.70307837
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48830572
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44301856
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.36648012
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.19000659
13XRN2_22483619_ChIP-Seq_HELA_Human2.16638961
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.13579906
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04793535
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.03370764
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94826458
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94250523
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93039682
20VDR_21846776_ChIP-Seq_THP-1_Human1.92793663
21CIITA_25753668_ChIP-Seq_RAJI_Human1.92665640
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92606253
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90609419
24AR_21909140_ChIP-Seq_LNCAP_Human1.86404120
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.78647625
26* VDR_23849224_ChIP-Seq_CD4+_Human1.74714160
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73396212
28FOXP3_21729870_ChIP-Seq_TREG_Human1.71473719
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71281886
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71098651
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70009470
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67098776
33LXR_22292898_ChIP-Seq_THP-1_Human1.67098468
34ZNF263_19887448_ChIP-Seq_K562_Human1.64548343
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63976116
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63776034
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59103859
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58383084
39TTF2_22483619_ChIP-Seq_HELA_Human1.55370141
40* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54683954
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53635189
42* GABP_19822575_ChIP-Seq_HepG2_Human1.53065267
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53030950
44DCP1A_22483619_ChIP-Seq_HELA_Human1.52807722
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48602014
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46263614
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43350392
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42870003
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41572074
50KDM5A_27292631_Chip-Seq_BREAST_Human1.40676369
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40532487
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37794210
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37403972
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32643338
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32251825
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31571804
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31298100
58RACK7_27058665_Chip-Seq_MCF-7_Human1.30267362
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28877424
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27217868
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25444558
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23940644
63NCOR1_26117541_ChIP-Seq_K562_Human1.23591671
64KDM2B_26808549_Chip-Seq_DND41_Human1.22732867
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21352388
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20936618
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.20423003
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.20319773
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19335085
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17768269
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17665055
72* P68_20966046_ChIP-Seq_HELA_Human1.17311505
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.17160598
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16560026
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16357689
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12807107
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11012141
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10757642
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10318782
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10267152
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09995799
82TFEB_21752829_ChIP-Seq_HELA_Human1.09797818
83UTX_26944678_Chip-Seq_JUKART_Human1.09472301
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08807449
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07800181
86* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05754707
87MAF_26560356_Chip-Seq_TH1_Human1.05739052
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05358533
89ELK1_19687146_ChIP-ChIP_HELA_Human1.04357769
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02559969
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.01965537
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01805883
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00599892
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.00546601
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00141147
96TCF7_22412390_ChIP-Seq_EML_Mouse0.99768330
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99107076
98* SPI1_23547873_ChIP-Seq_NB4_Human0.99087405
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97783049
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97696692
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96101062
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95269933
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.94912898
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94408035
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94020812
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93995710
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92618362
108SCL_19346495_ChIP-Seq_HPC-7_Human0.91188028
109MYB_26560356_Chip-Seq_TH1_Human0.88629620
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88271457
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86834676
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.86377610
113MYB_26560356_Chip-Seq_TH2_Human0.86347820
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86336013
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85908004
116MAF_26560356_Chip-Seq_TH2_Human0.85654847
117VDR_24763502_ChIP-Seq_THP-1_Human0.84514874
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.84157309
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83350716
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83303446
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82980154
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82068616
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.81390125
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80968467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.73329861
2MP0003693_abnormal_embryo_hatching4.42082428
3MP0003111_abnormal_nucleus_morphology4.37802930
4MP0008057_abnormal_DNA_replication4.14429012
5MP0003077_abnormal_cell_cycle3.79657940
6* MP0004957_abnormal_blastocyst_morpholog3.76455554
7MP0002396_abnormal_hematopoietic_system3.02809728
8MP0008058_abnormal_DNA_repair2.95491911
9MP0010352_gastrointestinal_tract_polyps2.80610429
10MP0008007_abnormal_cellular_replicative2.49784249
11MP0001730_embryonic_growth_arrest2.43772679
12MP0000350_abnormal_cell_proliferation2.32779138
13MP0004185_abnormal_adipocyte_glucose2.24348330
14MP0002877_abnormal_melanocyte_morpholog2.22391334
15MP0010307_abnormal_tumor_latency2.15941138
16MP0005451_abnormal_body_composition2.13884654
17* MP0008932_abnormal_embryonic_tissue2.02634050
18MP0000490_abnormal_crypts_of1.99312339
19MP0004808_abnormal_hematopoietic_stem1.95767388
20MP0008877_abnormal_DNA_methylation1.86479005
21MP0003123_paternal_imprinting1.84988833
22MP0003763_abnormal_thymus_physiology1.74424718
23MP0009278_abnormal_bone_marrow1.73015421
24MP0001672_abnormal_embryogenesis/_devel1.72872895
25MP0005380_embryogenesis_phenotype1.72872895
26MP0005076_abnormal_cell_differentiation1.72122527
27MP0001697_abnormal_embryo_size1.71381744
28* MP0002019_abnormal_tumor_incidence1.64055278
29MP0001545_abnormal_hematopoietic_system1.63140909
30MP0005397_hematopoietic_system_phenotyp1.63140909
31MP0002398_abnormal_bone_marrow1.62019368
32* MP0002080_prenatal_lethality1.62016359
33MP0003984_embryonic_growth_retardation1.60760935
34* MP0000703_abnormal_thymus_morphology1.59014172
35MP0000313_abnormal_cell_death1.57371016
36MP0002088_abnormal_embryonic_growth/wei1.57321620
37MP0003786_premature_aging1.56048317
38MP0004233_abnormal_muscle_weight1.54557017
39MP0004197_abnormal_fetal_growth/weight/1.52896893
40* MP0002085_abnormal_embryonic_tissue1.52737385
41MP0002084_abnormal_developmental_patter1.47283992
42* MP0002722_abnormal_immune_system1.46218751
43MP0000678_abnormal_parathyroid_gland1.45729822
44MP0005058_abnormal_lysosome_morphology1.45455142
45MP0000689_abnormal_spleen_morphology1.43984407
46* MP0002086_abnormal_extraembryonic_tissu1.41828133
47MP0009333_abnormal_splenocyte_physiolog1.39492784
48MP0008260_abnormal_autophagy1.39262202
49MP0010234_abnormal_vibrissa_follicle1.36495596
50MP0001661_extended_life_span1.35232390
51MP0000685_abnormal_immune_system1.34865383
52MP0005501_abnormal_skin_physiology1.33834802
53MP0001800_abnormal_humoral_immune1.26197428
54MP0002429_abnormal_blood_cell1.22734297
55MP0006054_spinal_hemorrhage1.22046078
56MP0003567_abnormal_fetal_cardiomyocyte1.15787097
57MP0000716_abnormal_immune_system1.14839029
58MP0003121_genomic_imprinting1.12965395
59MP0005666_abnormal_adipose_tissue1.08924577
60MP0003453_abnormal_keratinocyte_physiol1.08688924
61MP0003315_abnormal_perineum_morphology1.07201016
62MP0003705_abnormal_hypodermis_morpholog1.06891214
63MP0001293_anophthalmia1.04687403
64MP0002796_impaired_skin_barrier1.00845493
65MP0010030_abnormal_orbit_morphology0.99967790
66MP0002452_abnormal_antigen_presenting0.99648922
67MP0000566_synostosis0.99517649
68MP0001835_abnormal_antigen_presentation0.97904970
69MP0001915_intracranial_hemorrhage0.97645920
70MP0002420_abnormal_adaptive_immunity0.97370139
71MP0001819_abnormal_immune_cell0.94818323
72MP0000003_abnormal_adipose_tissue0.93408925
73MP0000537_abnormal_urethra_morphology0.93262630
74MP0004858_abnormal_nervous_system0.92848468
75MP0002210_abnormal_sex_determination0.91400131
76MP0003890_abnormal_embryonic-extraembry0.91249092
77MP0003566_abnormal_cell_adhesion0.91128306
78MP0001346_abnormal_lacrimal_gland0.90845426
79MP0009672_abnormal_birth_weight0.88949166
80MP0000858_altered_metastatic_potential0.88600334
81MP0002249_abnormal_larynx_morphology0.87682480
82MP0005023_abnormal_wound_healing0.86135129
83MP0002405_respiratory_system_inflammati0.86105737
84MP0002653_abnormal_ependyma_morphology0.85823285
85MP0001145_abnormal_male_reproductive0.85625820
86MP0006035_abnormal_mitochondrial_morpho0.84455350
87MP0002009_preneoplasia0.83999422
88MP0003119_abnormal_digestive_system0.83193068
89MP0000477_abnormal_intestine_morphology0.83157685
90MP0009697_abnormal_copulation0.82973870
91MP0002723_abnormal_immune_serum0.82836913
92MP0005375_adipose_tissue_phenotype0.81954065
93MP0000465_gastrointestinal_hemorrhage0.81336740
94MP0002163_abnormal_gland_morphology0.81166552
95MP0009931_abnormal_skin_appearance0.79690200
96MP0005621_abnormal_cell_physiology0.79435401
97MP0005384_cellular_phenotype0.79109021
98MP0002089_abnormal_postnatal_growth/wei0.78666429
99MP0001873_stomach_inflammation0.78391717
100MP0000358_abnormal_cell_content/0.78006031
101MP0004264_abnormal_extraembryonic_tissu0.77531902
102MP0001348_abnormal_lacrimal_gland0.77064322
103MP0005174_abnormal_tail_pigmentation0.75409938
104MP0001849_ear_inflammation0.73719859
105MP0002697_abnormal_eye_size0.72772651
106MP0009053_abnormal_anal_canal0.72087630
107MP0010155_abnormal_intestine_physiology0.71990198
108MP0003718_maternal_effect0.71004684
109MP0002166_altered_tumor_susceptibility0.70564281
110MP0001929_abnormal_gametogenesis0.69583157
111MP0002111_abnormal_tail_morphology0.68472868
112MP0010630_abnormal_cardiac_muscle0.68413673
113MP0003385_abnormal_body_wall0.68173139
114MP0002075_abnormal_coat/hair_pigmentati0.68158238
115MP0003866_abnormal_defecation0.67920743
116MP0001881_abnormal_mammary_gland0.67868604
117MP0005220_abnormal_exocrine_pancreas0.67202728
118MP0005671_abnormal_response_to0.67188902
119MP0002970_abnormal_white_adipose0.66792495
120MP0001853_heart_inflammation0.66693414
121MP0009703_decreased_birth_body0.66681041
122MP0002092_abnormal_eye_morphology0.66613699
123MP0004947_skin_inflammation0.66402589
124MP0003806_abnormal_nucleotide_metabolis0.66251107
125MP0003436_decreased_susceptibility_to0.65171700
126MP0004133_heterotaxia0.64654254
127MP0000653_abnormal_sex_gland0.64278761
128MP0003656_abnormal_erythrocyte_physiolo0.64174210
129MP0000428_abnormal_craniofacial_morphol0.63391668
130MP0003448_altered_tumor_morphology0.62926796
131MP0001216_abnormal_epidermal_layer0.62534622
132MP0008770_decreased_survivor_rate0.62485983
133MP0003303_peritoneal_inflammation0.62223142
134MP0000371_diluted_coat_color0.62088180
135MP0000733_abnormal_muscle_development0.61910418
136MP0005000_abnormal_immune_tolerance0.61266852
137MP0005387_immune_system_phenotype0.60908339
138MP0001790_abnormal_immune_system0.60908339
139MP0003115_abnormal_respiratory_system0.60236594
140MP0002060_abnormal_skin_morphology0.59677255
141MP0003221_abnormal_cardiomyocyte_apopto0.58344645

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.18357894
2Abnormality of cells of the erythroid lineage (HP:0012130)3.98515769
3Ependymoma (HP:0002888)3.91051826
4Abnormal number of erythroid precursors (HP:0012131)3.81483923
5Birth length less than 3rd percentile (HP:0003561)3.58338193
6Selective tooth agenesis (HP:0001592)3.52692046
7Medulloblastoma (HP:0002885)3.50085212
8Colon cancer (HP:0003003)3.41134297
9Chromsome breakage (HP:0040012)3.32712585
10Broad distal phalanx of finger (HP:0009836)3.27503398
11Abnormal gallbladder physiology (HP:0012438)3.18799627
12Cholecystitis (HP:0001082)3.18799627
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13360347
14Basal cell carcinoma (HP:0002671)3.11261027
15Abnormal number of incisors (HP:0011064)3.00152367
16Microvesicular hepatic steatosis (HP:0001414)2.97932197
17Oral leukoplakia (HP:0002745)2.91530322
18Progressive muscle weakness (HP:0003323)2.91503458
19Patellar aplasia (HP:0006443)2.88124764
20Agnosia (HP:0010524)2.84842046
21Reticulocytosis (HP:0001923)2.83476504
22Breast hypoplasia (HP:0003187)2.82208607
23Abnormality of chromosome stability (HP:0003220)2.79490774
24Rhabdomyosarcoma (HP:0002859)2.73914005
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72277112
26Absent thumb (HP:0009777)2.71257538
27Degeneration of anterior horn cells (HP:0002398)2.67197095
28Abnormality of the anterior horn cell (HP:0006802)2.67197095
29Aplasia/Hypoplasia of the patella (HP:0006498)2.65206724
30IgM deficiency (HP:0002850)2.64401175
31Ragged-red muscle fibers (HP:0003200)2.62545989
32Insomnia (HP:0100785)2.61514404
33Myelodysplasia (HP:0002863)2.60234981
34Increased nuchal translucency (HP:0010880)2.59798740
35Pallor (HP:0000980)2.57135804
36Meckel diverticulum (HP:0002245)2.55869368
37Abnormality of the preputium (HP:0100587)2.54980849
38Hyperacusis (HP:0010780)2.49880090
39Abnormality of the ileum (HP:0001549)2.49419938
40High anterior hairline (HP:0009890)2.48687215
41Abnormality of the astrocytes (HP:0100707)2.47000911
42Astrocytoma (HP:0009592)2.47000911
43Neoplasm of striated muscle (HP:0009728)2.45149244
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.44978480
45Thrombocytosis (HP:0001894)2.43483231
46Macrocytic anemia (HP:0001972)2.39769625
47Ulnar bowing (HP:0003031)2.38817575
48Neoplasm of the pancreas (HP:0002894)2.38019057
49Proximal placement of thumb (HP:0009623)2.37227623
50Aplastic anemia (HP:0001915)2.35951766
5111 pairs of ribs (HP:0000878)2.33607127
52Achilles tendon contracture (HP:0001771)2.28760193
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28218874
54Short 4th metacarpal (HP:0010044)2.28218874
55Squamous cell carcinoma (HP:0002860)2.27782132
56Small intestinal stenosis (HP:0012848)2.25659070
57Duodenal stenosis (HP:0100867)2.25659070
58Deviation of the thumb (HP:0009603)2.25555423
59Lymphoma (HP:0002665)2.24589766
60Carpal bone hypoplasia (HP:0001498)2.23025891
61Amaurosis fugax (HP:0100576)2.21500427
62Cellulitis (HP:0100658)2.19966669
63Long palpebral fissure (HP:0000637)2.18533892
64Neoplasm of the oral cavity (HP:0100649)2.18078095
65Bone marrow hypocellularity (HP:0005528)2.17683130
66Cafe-au-lait spot (HP:0000957)2.17666163
67Prominent nose (HP:0000448)2.17293626
68Truncus arteriosus (HP:0001660)2.17287955
69Glioma (HP:0009733)2.16338760
70Ectopic kidney (HP:0000086)2.16128547
71Impulsivity (HP:0100710)2.16072329
72Rough bone trabeculation (HP:0100670)2.15740564
73Tracheoesophageal fistula (HP:0002575)2.15400382
74Progressive external ophthalmoplegia (HP:0000590)2.14923115
75Abnormality of cochlea (HP:0000375)2.14626352
76Abnormality of the thoracic spine (HP:0100711)2.13997604
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13300364
78Absent radius (HP:0003974)2.12749530
79Disproportionate tall stature (HP:0001519)2.12462687
80Abnormality of the carotid arteries (HP:0005344)2.07886149
81Pointed chin (HP:0000307)2.05874001
82Trismus (HP:0000211)2.05345419
83Atresia of the external auditory canal (HP:0000413)2.05289771
84Abnormality of reticulocytes (HP:0004312)2.04471065
85Thoracic kyphosis (HP:0002942)2.03674128
86Premature graying of hair (HP:0002216)2.03604705
87Abnormality of the calcaneus (HP:0008364)2.03399959
88Abnormality of the fingertips (HP:0001211)2.02381085
89Duplicated collecting system (HP:0000081)2.01929965
90Missing ribs (HP:0000921)2.01401825
91Centrally nucleated skeletal muscle fibers (HP:0003687)2.00872713
92Cellular immunodeficiency (HP:0005374)1.99509967
93Poikiloderma (HP:0001029)1.98768042
94Recurrent viral infections (HP:0004429)1.97760601
95Distal lower limb amyotrophy (HP:0008944)1.97136691
96Absent forearm bone (HP:0003953)1.96192212
97Aplasia involving forearm bones (HP:0009822)1.96192212
98Flared metaphyses (HP:0003015)1.95744351
99Orthostatic hypotension (HP:0001278)1.94232071
100Deep palmar crease (HP:0006191)1.93935183
101Pseudobulbar signs (HP:0002200)1.93499606
102Overriding aorta (HP:0002623)1.93442166
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92712311
104Absent epiphyses (HP:0010577)1.92712311
105Urethral obstruction (HP:0000796)1.92312014
106Multiple enchondromatosis (HP:0005701)1.91843095
107Overlapping toe (HP:0001845)1.90850211
108Adenoma sebaceum (HP:0009720)1.90723276
109Angiofibromas (HP:0010615)1.90723276
110Asplenia (HP:0001746)1.90604218
111Elfin facies (HP:0004428)1.90332916
112Sloping forehead (HP:0000340)1.90172366
113Abnormality of DNA repair (HP:0003254)1.89617909
114Abnormality of the Achilles tendon (HP:0005109)1.89074922
115Abnormality of the duodenum (HP:0002246)1.86559923
116Microretrognathia (HP:0000308)1.85693863
117Long eyelashes (HP:0000527)1.85675682
118Renal duplication (HP:0000075)1.85412596
119Recurrent bronchitis (HP:0002837)1.84688724
120Panhypogammaglobulinemia (HP:0003139)1.84338992
121Dysmetric saccades (HP:0000641)1.84287014
122Hypertensive crisis (HP:0100735)1.84169392
123Papilloma (HP:0012740)1.83939106
124Verrucae (HP:0200043)1.83939106
125Broad face (HP:0000283)1.83405422
126Abnormality of T cells (HP:0002843)1.83128733
127Skin tags (HP:0010609)1.81580875
128Premature skin wrinkling (HP:0100678)1.80735599
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.79993618
130Acute lymphatic leukemia (HP:0006721)1.79061838
131Ankyloglossia (HP:0010296)1.77851814
132Cholelithiasis (HP:0001081)1.77399945
133Abnormality of B cell number (HP:0010975)1.77276709
134B lymphocytopenia (HP:0010976)1.77276709
135Abnormality of glycolysis (HP:0004366)1.77185948
136Slender long bone (HP:0003100)1.76726872
137Short thumb (HP:0009778)1.76271489
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.75437307
139Biconcave vertebral bodies (HP:0004586)1.75405144
140Abnormality of T cell physiology (HP:0011840)1.75253587
141Patellar dislocation (HP:0002999)1.74351900
142Leukopenia (HP:0001882)1.74270004
143Abnormality of the umbilical cord (HP:0010881)1.72953116
144Volvulus (HP:0002580)1.72491826
145Duplication of thumb phalanx (HP:0009942)1.70207406
146Colitis (HP:0002583)1.68620304
147Entropion (HP:0000621)1.66476972
148Spastic diplegia (HP:0001264)1.65186548
149Metaphyseal cupping (HP:0003021)1.65051698
150Horseshoe kidney (HP:0000085)1.64624455
151Cortical dysplasia (HP:0002539)1.64000090
152Abnormality of oral frenula (HP:0000190)1.62684454
153Hypergonadotropic hypogonadism (HP:0000815)1.62431680
154Septate vagina (HP:0001153)1.60618222
155Abnormality of the gallbladder (HP:0005264)1.59931439
156Skull defect (HP:0001362)1.59628598
157Myopathic facies (HP:0002058)1.58934999
158Abnormal large intestine physiology (HP:0012700)1.57988213
159Ureteral duplication (HP:0000073)1.57073012
160Bowel incontinence (HP:0002607)1.55658800
161Self-mutilation (HP:0000742)1.54582240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.34799714
2SMG14.34673375
3MAP3K103.74163903
4EEF2K3.55367139
5BUB13.41748823
6WEE13.30764476
7NEK22.98786368
8CDK122.51141016
9PRPF4B2.39096502
10IRAK32.36487510
11PASK2.28623626
12MAP4K12.25573247
13PKN22.09025699
14VRK22.08898205
15TTK2.03408930
16TLK12.01588745
17RPS6KB21.91253711
18TSSK61.82444485
19CDK41.82418091
20CDK71.76385647
21ATR1.75594310
22STK101.75096015
23EIF2AK11.65467349
24TESK21.61157333
25ACVR1B1.59928417
26NEK11.57723823
27SCYL21.53994208
28PLK11.53816127
29SIK11.53165984
30SRPK11.49454270
31TRIB31.47115412
32MAP3K81.47038117
33STK41.41322596
34AURKB1.38767292
35NME21.36048358
36TGFBR11.35636844
37RPS6KA41.35262542
38GRK61.33469373
39PAK41.27874608
40MKNK11.24824977
41LRRK21.24652246
42CHEK11.22139315
43BRSK21.20051555
44CHEK21.19477583
45DYRK31.19363124
46VRK11.18412284
47TAOK21.15113912
48CDK191.13934865
49FLT31.13673863
50PIM11.07683520
51AURKA1.05869919
52BRAF1.03986590
53BRD41.03079689
54MAP2K31.01066368
55FGFR41.00925246
56PBK1.00258220
57ARAF0.98700631
58BTK0.96686359
59ALK0.91061029
60BCKDK0.89832201
61BRSK10.89637891
62TAF10.89431314
63MST1R0.88163794
64MAP3K130.87602039
65CDK20.87435645
66CLK10.83141929
67MKNK20.83004027
68EIF2AK30.82896388
69STK160.82720552
70ATM0.82189374
71PLK40.80443256
72BMX0.79777053
73PLK30.79462527
74IRAK20.78169714
75CSF1R0.75850235
76CDK60.75299972
77CCNB10.70238500
78MTOR0.68393386
79ICK0.68214551
80MAPKAPK30.67672350
81JAK30.67439756
82KDR0.67137676
83MAP3K110.66120199
84BLK0.63143089
85EPHA20.62611079
86ZAP700.60148700
87ERN10.59379904
88PAK10.57749654
89CDK10.57194596
90CSNK2A20.55209180
91CAMK1D0.53803549
92MELK0.53651582
93NME10.53181740
94MAP2K20.51293388
95MAPK110.51212366
96TYK20.50569287
97KSR20.50403998
98PIM20.50281079
99IRAK40.49880661
100PRKD30.46125525
101PTK60.45387236
102AKT20.44817850
103RPS6KA50.44610013
104CDK11A0.43847893
105CSNK2A10.42535845
106TTN0.41988606
107RAF10.41610123
108SYK0.40393846
109CDK80.39013053
110CDK150.38139431
111PDGFRA0.36145353
112ZAK0.35528444
113CDK90.35480163
114RPS6KL10.34825244
115RPS6KC10.34825244
116RPS6KA60.34512718
117LMTK20.34383252
118MAPKAPK20.33902516
119ILK0.33717899
120MAP3K10.33449923
121PRKDC0.32988839
122TESK10.32972480
123PRKCI0.32663004
124CDK180.31735845
125PAK20.31433769
126LCK0.30987352
127DAPK10.29806330
128SIK20.29508112
129RPS6KA10.28653303

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.66112987
2* Mismatch repair_Homo sapiens_hsa034304.40340677
3Spliceosome_Homo sapiens_hsa030403.33238333
4* Base excision repair_Homo sapiens_hsa034103.30030666
5Ribosome_Homo sapiens_hsa030103.17993133
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99924780
7RNA transport_Homo sapiens_hsa030132.89121967
8One carbon pool by folate_Homo sapiens_hsa006702.84608852
9Cell cycle_Homo sapiens_hsa041102.82422684
10* Homologous recombination_Homo sapiens_hsa034402.75854304
11* Nucleotide excision repair_Homo sapiens_hsa034202.61811562
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41715415
13Non-homologous end-joining_Homo sapiens_hsa034502.23197197
14Fanconi anemia pathway_Homo sapiens_hsa034602.14565621
15RNA polymerase_Homo sapiens_hsa030202.11662510
16Proteasome_Homo sapiens_hsa030502.00908742
17* Pyrimidine metabolism_Homo sapiens_hsa002401.99849244
18mRNA surveillance pathway_Homo sapiens_hsa030151.85573150
19RNA degradation_Homo sapiens_hsa030181.68914269
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64576781
21p53 signaling pathway_Homo sapiens_hsa041151.55701101
22Systemic lupus erythematosus_Homo sapiens_hsa053221.48968740
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46957838
24Primary immunodeficiency_Homo sapiens_hsa053401.44892031
25Viral carcinogenesis_Homo sapiens_hsa052031.24298891
26Epstein-Barr virus infection_Homo sapiens_hsa051691.20044508
27Other glycan degradation_Homo sapiens_hsa005111.16417332
28Basal transcription factors_Homo sapiens_hsa030221.16348317
29Antigen processing and presentation_Homo sapiens_hsa046121.15979213
30Galactose metabolism_Homo sapiens_hsa000521.15284270
31Herpes simplex infection_Homo sapiens_hsa051681.10649734
32* HTLV-I infection_Homo sapiens_hsa051661.00454977
33Biosynthesis of amino acids_Homo sapiens_hsa012300.91225992
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90604663
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.89393882
36Pentose phosphate pathway_Homo sapiens_hsa000300.89270827
37* Purine metabolism_Homo sapiens_hsa002300.87702998
38B cell receptor signaling pathway_Homo sapiens_hsa046620.87581527
39Chronic myeloid leukemia_Homo sapiens_hsa052200.86090892
40MicroRNAs in cancer_Homo sapiens_hsa052060.84522621
41Small cell lung cancer_Homo sapiens_hsa052220.84117327
42Vitamin B6 metabolism_Homo sapiens_hsa007500.83893756
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83420550
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80474129
45Oocyte meiosis_Homo sapiens_hsa041140.79098206
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77954796
47Sulfur relay system_Homo sapiens_hsa041220.74839851
48Notch signaling pathway_Homo sapiens_hsa043300.74057350
49Selenocompound metabolism_Homo sapiens_hsa004500.71204376
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.71168566
51Apoptosis_Homo sapiens_hsa042100.70152748
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69168626
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69144227
54Thyroid cancer_Homo sapiens_hsa052160.67423629
55Colorectal cancer_Homo sapiens_hsa052100.67180029
56Acute myeloid leukemia_Homo sapiens_hsa052210.66143779
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.65866648
58Measles_Homo sapiens_hsa051620.64870049
59Pyruvate metabolism_Homo sapiens_hsa006200.61510411
60Alcoholism_Homo sapiens_hsa050340.61239280
61Hepatitis B_Homo sapiens_hsa051610.60987952
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60961588
63Non-small cell lung cancer_Homo sapiens_hsa052230.60767121
64Endometrial cancer_Homo sapiens_hsa052130.60481688
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59987273
66Legionellosis_Homo sapiens_hsa051340.59441175
67Lysine degradation_Homo sapiens_hsa003100.58734747
68Glioma_Homo sapiens_hsa052140.55568184
69Shigellosis_Homo sapiens_hsa051310.54907471
70Bladder cancer_Homo sapiens_hsa052190.54639429
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.53360022
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52947149
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.49771886
74Folate biosynthesis_Homo sapiens_hsa007900.49707015
75Basal cell carcinoma_Homo sapiens_hsa052170.48862336
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45676261
77N-Glycan biosynthesis_Homo sapiens_hsa005100.44925919
78Insulin signaling pathway_Homo sapiens_hsa049100.43942377
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43649100
80Viral myocarditis_Homo sapiens_hsa054160.43512344
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43318815
82Hematopoietic cell lineage_Homo sapiens_hsa046400.42536350
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42467826
84Carbon metabolism_Homo sapiens_hsa012000.41675150
85Pancreatic cancer_Homo sapiens_hsa052120.41295634
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41195394
87Prion diseases_Homo sapiens_hsa050200.40568284
88mTOR signaling pathway_Homo sapiens_hsa041500.39472850
89Influenza A_Homo sapiens_hsa051640.39379913
90HIF-1 signaling pathway_Homo sapiens_hsa040660.39094720
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38631218
92Leishmaniasis_Homo sapiens_hsa051400.38328260
93AMPK signaling pathway_Homo sapiens_hsa041520.37440467
94Pathways in cancer_Homo sapiens_hsa052000.37392794
95ErbB signaling pathway_Homo sapiens_hsa040120.37341583
96T cell receptor signaling pathway_Homo sapiens_hsa046600.36687490
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34984889
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34089189
99Renin-angiotensin system_Homo sapiens_hsa046140.33657870
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33068805
101Hippo signaling pathway_Homo sapiens_hsa043900.32843156
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.31640494
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30400855
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.29757166
105Renal cell carcinoma_Homo sapiens_hsa052110.29755203
106Inositol phosphate metabolism_Homo sapiens_hsa005620.29223823
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28548587
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28378640
109Melanoma_Homo sapiens_hsa052180.27287550
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.26927149
111Glutathione metabolism_Homo sapiens_hsa004800.26707966
112Adherens junction_Homo sapiens_hsa045200.26209614
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25615432
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.25461917
115TGF-beta signaling pathway_Homo sapiens_hsa043500.25176353
116Prostate cancer_Homo sapiens_hsa052150.24974207
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24926556
118VEGF signaling pathway_Homo sapiens_hsa043700.23821261
119Toxoplasmosis_Homo sapiens_hsa051450.23512073
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21969477
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21956556
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21684913
123Fructose and mannose metabolism_Homo sapiens_hsa000510.21139145
124Hedgehog signaling pathway_Homo sapiens_hsa043400.19235779

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