POLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.37592042
2* DNA strand elongation involved in DNA replication (GO:0006271)5.15738209
3* telomere maintenance via semi-conservative replication (GO:0032201)5.08295175
4* DNA strand elongation (GO:0022616)4.91078767
5* DNA replication initiation (GO:0006270)4.84032771
6DNA deamination (GO:0045006)4.73026768
7sister chromatid segregation (GO:0000819)4.63289696
8DNA replication checkpoint (GO:0000076)4.57309067
9* telomere maintenance via recombination (GO:0000722)4.56976870
10ribosomal small subunit assembly (GO:0000028)4.46801195
11nucleobase biosynthetic process (GO:0046112)4.34357063
12protein K6-linked ubiquitination (GO:0085020)4.33438739
13* mitotic recombination (GO:0006312)4.22113961
14purine nucleobase biosynthetic process (GO:0009113)4.22055619
15CENP-A containing nucleosome assembly (GO:0034080)4.13905902
16mitotic sister chromatid cohesion (GO:0007064)4.07810734
17ribosome assembly (GO:0042255)4.05808768
18chromatin remodeling at centromere (GO:0031055)4.05275308
19* telomere maintenance via telomere lengthening (GO:0010833)3.99791767
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.98477090
21ribosome biogenesis (GO:0042254)3.95978016
22DNA unwinding involved in DNA replication (GO:0006268)3.94513689
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.89821430
24mitotic metaphase plate congression (GO:0007080)3.81676702
25IMP biosynthetic process (GO:0006188)3.80286540
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.76611974
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76611974
28protein localization to kinetochore (GO:0034501)3.75610535
29kinetochore organization (GO:0051383)3.75243815
30formation of translation preinitiation complex (GO:0001731)3.71409412
31proteasome assembly (GO:0043248)3.71073293
32DNA replication-independent nucleosome organization (GO:0034724)3.70929353
33DNA replication-independent nucleosome assembly (GO:0006336)3.70929353
34maturation of SSU-rRNA (GO:0030490)3.67794265
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65447922
36kinetochore assembly (GO:0051382)3.62485218
37ribonucleoprotein complex biogenesis (GO:0022613)3.60632879
38DNA replication-dependent nucleosome assembly (GO:0006335)3.58607764
39DNA replication-dependent nucleosome organization (GO:0034723)3.58607764
40DNA synthesis involved in DNA repair (GO:0000731)3.57931654
41DNA topological change (GO:0006265)3.57544078
42mitotic nuclear envelope disassembly (GO:0007077)3.55388324
43regulation of translational fidelity (GO:0006450)3.55250503
44DNA ligation (GO:0006266)3.54547627
45chromosome condensation (GO:0030261)3.53926728
46transcription-coupled nucleotide-excision repair (GO:0006283)3.45144881
47spliceosomal snRNP assembly (GO:0000387)3.37219454
48base-excision repair (GO:0006284)3.35480362
49pore complex assembly (GO:0046931)3.35134929
50chromatin assembly or disassembly (GO:0006333)3.34481867
51histone exchange (GO:0043486)3.34021634
52chromosome segregation (GO:0007059)3.33969772
53regulation of mitochondrial translation (GO:0070129)3.32490593
54protein localization to chromosome, centromeric region (GO:0071459)3.32074931
55ribosomal large subunit biogenesis (GO:0042273)3.31926159
56DNA duplex unwinding (GO:0032508)3.31761873
57rRNA modification (GO:0000154)3.31540561
58pseudouridine synthesis (GO:0001522)3.29262987
59metaphase plate congression (GO:0051310)3.28580337
60rRNA processing (GO:0006364)3.26706277
61nuclear pore organization (GO:0006999)3.26387860
62IMP metabolic process (GO:0046040)3.26293480
63attachment of spindle microtubules to kinetochore (GO:0008608)3.24655693
64DNA geometric change (GO:0032392)3.24574010
65deoxyribonucleotide biosynthetic process (GO:0009263)3.24269828
66DNA conformation change (GO:0071103)3.23227133
67membrane disassembly (GO:0030397)3.22914665
68nuclear envelope disassembly (GO:0051081)3.22914665
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.21977054
70termination of RNA polymerase III transcription (GO:0006386)3.21977054
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.21262864
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19936267
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19088473
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17502600
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.16972941
76rRNA metabolic process (GO:0016072)3.16490123
77DNA packaging (GO:0006323)3.15946910
78ribosomal small subunit biogenesis (GO:0042274)3.15505989
79* telomere maintenance (GO:0000723)3.14953552
80* telomere organization (GO:0032200)3.14951394
81establishment of viral latency (GO:0019043)3.14723930
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14488601
83* cell cycle G1/S phase transition (GO:0044843)3.13749651
84* G1/S transition of mitotic cell cycle (GO:0000082)3.13749651
85folic acid metabolic process (GO:0046655)3.12636753
86folic acid-containing compound biosynthetic process (GO:0009396)3.12539007
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11727085
88replication fork processing (GO:0031297)3.11378943
89DNA strand renaturation (GO:0000733)3.10106542
90establishment of chromosome localization (GO:0051303)3.09850361
91viral transcription (GO:0019083)3.08678978
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07948230
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07305192
94double-strand break repair via nonhomologous end joining (GO:0006303)3.05832098
95non-recombinational repair (GO:0000726)3.05832098
96translational termination (GO:0006415)3.05471533
97heterochromatin organization (GO:0070828)3.02820475
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01745427
99meiotic chromosome segregation (GO:0045132)3.01056991
100nuclear pore complex assembly (GO:0051292)3.00372936
101viral mRNA export from host cell nucleus (GO:0046784)3.00250516
102regulation of centriole replication (GO:0046599)2.99150957
103regulation of centrosome cycle (GO:0046605)2.98296935
104spliceosomal complex assembly (GO:0000245)2.96720696
105* mitotic cell cycle (GO:0000278)2.96576621
1067-methylguanosine mRNA capping (GO:0006370)2.96536657
107chromatin assembly (GO:0031497)2.95495047
108maturation of 5.8S rRNA (GO:0000460)2.95280617
109regulation of chromosome segregation (GO:0051983)2.95122003
110protein localization to chromosome (GO:0034502)2.94461584
111positive regulation of chromosome segregation (GO:0051984)2.94259842
112ATP-dependent chromatin remodeling (GO:0043044)2.92543922
113RNA capping (GO:0036260)2.91941291
1147-methylguanosine RNA capping (GO:0009452)2.91941291
115regulation of spindle organization (GO:0090224)2.91073142
116DNA-dependent DNA replication (GO:0006261)2.90528432
117mismatch repair (GO:0006298)2.90427171
118establishment of integrated proviral latency (GO:0075713)2.90162207
119negative regulation of chromosome segregation (GO:0051985)2.89867201
120mitochondrial RNA metabolic process (GO:0000959)2.89503822
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89361089
122negative regulation of sister chromatid segregation (GO:0033046)2.89361089
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.89361089
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89361089
125protein complex localization (GO:0031503)2.89258246
126translational initiation (GO:0006413)2.89138585
127translational elongation (GO:0006414)2.88191639
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87661284
129negative regulation of ligase activity (GO:0051352)2.87661284
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87542206
131postreplication repair (GO:0006301)2.86121704
132sister chromatid cohesion (GO:0007062)2.85915960
133spindle checkpoint (GO:0031577)2.85915689
134mitotic sister chromatid segregation (GO:0000070)2.85686436
135V(D)J recombination (GO:0033151)2.84567514
136* DNA replication (GO:0006260)2.84516610
137transcription from RNA polymerase I promoter (GO:0006360)2.83327345
138negative regulation of mRNA processing (GO:0050686)2.82967358
139translesion synthesis (GO:0019985)2.82411050
140* chromosome organization (GO:0051276)2.81270449
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80861343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97409657
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13792581
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69971992
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65213420
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.48690787
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34902352
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.07241935
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00240963
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98418309
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.93500545
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87957268
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83751934
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81140958
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.79165850
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64752898
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40215753
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35819019
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31378878
19VDR_23849224_ChIP-Seq_CD4+_Human2.28556496
20XRN2_22483619_ChIP-Seq_HELA_Human2.23193940
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21874989
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21134410
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04681269
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99959559
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99341592
26AR_21909140_ChIP-Seq_LNCAP_Human1.93699459
27FOXP3_21729870_ChIP-Seq_TREG_Human1.92474018
28* E2F1_21310950_ChIP-Seq_MCF-7_Human1.91475124
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91179704
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89191902
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88754818
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85230281
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84208227
34* GABP_19822575_ChIP-Seq_HepG2_Human1.82357467
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80167655
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78151062
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76416987
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74377245
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72211292
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.69455724
41TTF2_22483619_ChIP-Seq_HELA_Human1.68705000
42ELK1_19687146_ChIP-ChIP_HELA_Human1.68497652
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.63961619
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63161220
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59660144
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.59196852
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57466672
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54656208
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52548662
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52263242
51CIITA_25753668_ChIP-Seq_RAJI_Human1.47274185
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46260487
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44763920
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43037452
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38655886
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37117116
57KDM5A_27292631_Chip-Seq_BREAST_Human1.31994797
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31105068
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30322684
60MYC_22102868_ChIP-Seq_BL_Human1.29533611
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25105391
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24095508
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.23224883
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22809210
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22293870
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22269659
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21183799
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18967932
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.17657036
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13519193
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11745774
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11313843
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07797467
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04668583
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04170621
76SPI1_23547873_ChIP-Seq_NB4_Human1.02460360
77TFEB_21752829_ChIP-Seq_HELA_Human1.02252458
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01832986
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97410841
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96998975
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96376645
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94689344
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94113886
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94065989
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92894519
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91127433
87MYC_18940864_ChIP-ChIP_HL60_Human0.90755228
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87771294
89VDR_21846776_ChIP-Seq_THP-1_Human0.86324199
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.86073471
91* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85551686
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85357282
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81628986
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80999956
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80638675
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.80298539
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79246036
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.79098863
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78979050
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78890059
101* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78227191
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78179655
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77977871
104ZNF263_19887448_ChIP-Seq_K562_Human0.77769598
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77457164
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75386774
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74516429
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72524747
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72129878
110CHD1_26751641_Chip-Seq_LNCaP_Human0.71535699
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.66631386
112NCOR1_26117541_ChIP-Seq_K562_Human0.66048230
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.65565679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.44280000
2MP0010094_abnormal_chromosome_stability4.77809828
3MP0003111_abnormal_nucleus_morphology4.40749976
4MP0008057_abnormal_DNA_replication4.14643309
5MP0004957_abnormal_blastocyst_morpholog4.12933979
6MP0003077_abnormal_cell_cycle3.96193434
7MP0008058_abnormal_DNA_repair3.67999639
8MP0008007_abnormal_cellular_replicative2.99224487
9MP0002396_abnormal_hematopoietic_system2.88304947
10MP0008932_abnormal_embryonic_tissue2.56545317
11MP0003123_paternal_imprinting2.32606365
12MP0003786_premature_aging2.26775936
13MP0000350_abnormal_cell_proliferation2.02333531
14MP0001730_embryonic_growth_arrest2.01624892
15MP0003718_maternal_effect1.98797658
16MP0009697_abnormal_copulation1.97962104
17MP0008877_abnormal_DNA_methylation1.95923655
18MP0010352_gastrointestinal_tract_polyps1.90719350
19MP0003186_abnormal_redox_activity1.84350031
20MP0000490_abnormal_crypts_of1.83744155
21MP0010307_abnormal_tumor_latency1.80642968
22MP0003806_abnormal_nucleotide_metabolis1.75490333
23MP0009333_abnormal_splenocyte_physiolog1.72768961
24MP0005397_hematopoietic_system_phenotyp1.71697675
25MP0001545_abnormal_hematopoietic_system1.71697675
26MP0004808_abnormal_hematopoietic_stem1.54001180
27MP0000313_abnormal_cell_death1.52642783
28MP0001672_abnormal_embryogenesis/_devel1.48482364
29MP0005380_embryogenesis_phenotype1.48482364
30MP0003763_abnormal_thymus_physiology1.48290942
31MP0002019_abnormal_tumor_incidence1.45923793
32MP0001697_abnormal_embryo_size1.44195438
33MP0001346_abnormal_lacrimal_gland1.43573326
34MP0006292_abnormal_olfactory_placode1.38148136
35MP0002080_prenatal_lethality1.36761307
36MP0002398_abnormal_bone_marrow1.36583747
37MP0001835_abnormal_antigen_presentation1.33552859
38MP0004233_abnormal_muscle_weight1.31868480
39MP0003984_embryonic_growth_retardation1.31072204
40MP0002163_abnormal_gland_morphology1.29397262
41MP0002009_preneoplasia1.28568010
42MP0000689_abnormal_spleen_morphology1.27406080
43MP0002722_abnormal_immune_system1.27006201
44MP0002088_abnormal_embryonic_growth/wei1.26718230
45MP0002877_abnormal_melanocyte_morpholog1.25779611
46MP0000703_abnormal_thymus_morphology1.22983701
47MP0001853_heart_inflammation1.22210441
48MP0009672_abnormal_birth_weight1.19633523
49MP0002132_abnormal_respiratory_system1.18583012
50MP0002085_abnormal_embryonic_tissue1.17167765
51MP0002210_abnormal_sex_determination1.16296930
52MP0003315_abnormal_perineum_morphology1.12785052
53MP0002086_abnormal_extraembryonic_tissu1.12288045
54MP0002429_abnormal_blood_cell1.09398691
55MP0002160_abnormal_reproductive_system1.06772835
56MP0003567_abnormal_fetal_cardiomyocyte1.06752320
57MP0005671_abnormal_response_to1.06157856
58MP0003121_genomic_imprinting1.04598438
59MP0004197_abnormal_fetal_growth/weight/1.04057823
60MP0004147_increased_porphyrin_level1.02471510
61MP0004185_abnormal_adipocyte_glucose1.02328734
62MP0000858_altered_metastatic_potential1.01623568
63MP0001293_anophthalmia1.00864943
64MP0009278_abnormal_bone_marrow1.00714730
65MP0001145_abnormal_male_reproductive0.99549573
66MP0000716_abnormal_immune_system0.99425817
67MP0006036_abnormal_mitochondrial_physio0.97211161
68MP0001800_abnormal_humoral_immune0.95275136
69MP0005075_abnormal_melanosome_morpholog0.95056785
70MP0000685_abnormal_immune_system0.94437440
71MP0001119_abnormal_female_reproductive0.93758430
72MP0002084_abnormal_developmental_patter0.93377581
73MP0006035_abnormal_mitochondrial_morpho0.93358260
74MP0000358_abnormal_cell_content/0.93126765
75MP0003941_abnormal_skin_development0.92505583
76MP0005389_reproductive_system_phenotype0.92455623
77MP0002938_white_spotting0.91349777
78MP0006054_spinal_hemorrhage0.91181770
79MP0002452_abnormal_antigen_presenting0.90999010
80MP0001661_extended_life_span0.90832903
81MP0009785_altered_susceptibility_to0.89650145
82MP0002420_abnormal_adaptive_immunity0.88147420
83MP0001819_abnormal_immune_cell0.87507750
84MP0005451_abnormal_body_composition0.87103723
85MP0001929_abnormal_gametogenesis0.86509654
86MP0002095_abnormal_skin_pigmentation0.84605493
87MP0000653_abnormal_sex_gland0.84593993
88MP0008995_early_reproductive_senescence0.84471494
89MP0005501_abnormal_skin_physiology0.84261133
90MP0005384_cellular_phenotype0.83538058
91MP0002723_abnormal_immune_serum0.80987769
92MP0002405_respiratory_system_inflammati0.79177049
93MP0003656_abnormal_erythrocyte_physiolo0.78845069
94MP0004133_heterotaxia0.77075026
95MP0005025_abnormal_response_to0.76905325
96MP0005076_abnormal_cell_differentiation0.76609334
97MP0010030_abnormal_orbit_morphology0.76530596
98MP0003705_abnormal_hypodermis_morpholog0.76092104
99MP0003890_abnormal_embryonic-extraembry0.75278055
100MP0005621_abnormal_cell_physiology0.72927198
101MP0003436_decreased_susceptibility_to0.72144282
102MP0003937_abnormal_limbs/digits/tail_de0.70121056
103MP0003448_altered_tumor_morphology0.69557415
104MP0003698_abnormal_male_reproductive0.69225016
105MP0001529_abnormal_vocalization0.67392117
106MP0001873_stomach_inflammation0.67125576
107MP0001919_abnormal_reproductive_system0.66671932
108MP0003699_abnormal_female_reproductive0.66266829
109MP0005000_abnormal_immune_tolerance0.65210640
110MP0002148_abnormal_hypersensitivity_rea0.65124329
111MP0001727_abnormal_embryo_implantation0.64886145
112MP0002161_abnormal_fertility/fecundity0.63466127
113MP0000015_abnormal_ear_pigmentation0.62720926
114MP0001764_abnormal_homeostasis0.61681052
115MP0002970_abnormal_white_adipose0.61264722
116MP0005266_abnormal_metabolism0.61196196
117MP0001915_intracranial_hemorrhage0.60588449
118MP0005174_abnormal_tail_pigmentation0.60500435
119MP0005220_abnormal_exocrine_pancreas0.58981530
120MP0002075_abnormal_coat/hair_pigmentati0.58831853
121MP0002006_tumorigenesis0.58617296
122MP0010155_abnormal_intestine_physiology0.58335074
123MP0002111_abnormal_tail_morphology0.57835317
124MP0002419_abnormal_innate_immunity0.57684802
125MP0001286_abnormal_eye_development0.57598448
126MP0003221_abnormal_cardiomyocyte_apopto0.57565321
127MP0001186_pigmentation_phenotype0.56420546
128MP0002697_abnormal_eye_size0.55056364
129MP0001881_abnormal_mammary_gland0.52494353
130MP0009379_abnormal_foot_pigmentation0.51843949
131MP0009703_decreased_birth_body0.51137224
132MP0003943_abnormal_hepatobiliary_system0.50784786

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.75458360
2Breast hypoplasia (HP:0003187)4.32995055
3Chromsome breakage (HP:0040012)4.21291859
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14501677
5Carpal bone hypoplasia (HP:0001498)4.03765146
6Abnormality of cells of the erythroid lineage (HP:0012130)4.02427270
7Abnormal number of erythroid precursors (HP:0012131)4.00956063
8Reticulocytopenia (HP:0001896)3.93434685
9Oral leukoplakia (HP:0002745)3.54699896
10Microvesicular hepatic steatosis (HP:0001414)3.48953671
11Patellar aplasia (HP:0006443)3.48291576
12Meckel diverticulum (HP:0002245)3.40770270
13Abnormality of chromosome stability (HP:0003220)3.31132054
14Rough bone trabeculation (HP:0100670)3.26426239
15Abnormality of the preputium (HP:0100587)3.26133138
16Abnormality of the ileum (HP:0001549)3.25056959
17Aplasia/Hypoplasia of the patella (HP:0006498)3.22228532
18Aplastic anemia (HP:0001915)3.15843858
19Abnormality of the anterior horn cell (HP:0006802)3.10287966
20Degeneration of anterior horn cells (HP:0002398)3.10287966
21Selective tooth agenesis (HP:0001592)3.09304135
22Abnormality of DNA repair (HP:0003254)3.01439916
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.93929131
24Absent thumb (HP:0009777)2.89759627
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87148473
26Myelodysplasia (HP:0002863)2.83174812
27Bone marrow hypocellularity (HP:0005528)2.81016665
28Colon cancer (HP:0003003)2.79667139
29Premature graying of hair (HP:0002216)2.76981405
30Absent radius (HP:0003974)2.75742189
31Increased nuchal translucency (HP:0010880)2.74891596
32Small intestinal stenosis (HP:0012848)2.69214790
33Duodenal stenosis (HP:0100867)2.69214790
34Abnormality of the heme biosynthetic pathway (HP:0010472)2.64800105
35Type I transferrin isoform profile (HP:0003642)2.61136190
36Microretrognathia (HP:0000308)2.60587953
37Squamous cell carcinoma (HP:0002860)2.58777398
38Aplasia involving forearm bones (HP:0009822)2.55830222
39Absent forearm bone (HP:0003953)2.55830222
40Medulloblastoma (HP:0002885)2.55785520
41Abnormality of cochlea (HP:0000375)2.50311665
42Cerebral hypomyelination (HP:0006808)2.50200488
43Pallor (HP:0000980)2.48104811
44Agnosia (HP:0010524)2.46110454
45Ectopic kidney (HP:0000086)2.45215780
46Abnormal trabecular bone morphology (HP:0100671)2.42508118
47Cellular immunodeficiency (HP:0005374)2.41894536
48Macrocytic anemia (HP:0001972)2.41772732
4911 pairs of ribs (HP:0000878)2.38447846
50Poikiloderma (HP:0001029)2.38227208
51Hypoplasia of the pons (HP:0012110)2.34497100
52Impulsivity (HP:0100710)2.32412878
53Tracheoesophageal fistula (HP:0002575)2.29160687
54Thrombocytosis (HP:0001894)2.27417384
55Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26412260
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25137072
57Horseshoe kidney (HP:0000085)2.24366035
58Cleft eyelid (HP:0000625)2.21941818
59Cafe-au-lait spot (HP:0000957)2.21938759
60Lymphoma (HP:0002665)2.20373742
61Pancytopenia (HP:0001876)2.20222626
62Clubbing of toes (HP:0100760)2.20211105
63Broad distal phalanx of finger (HP:0009836)2.20124542
64Abnormality of the duodenum (HP:0002246)2.19914880
65Abnormality of the pons (HP:0007361)2.18233801
66Neoplasm of the pancreas (HP:0002894)2.17776555
67Hypergonadotropic hypogonadism (HP:0000815)2.14829823
68Abnormal lung lobation (HP:0002101)2.14070945
69Duplicated collecting system (HP:0000081)2.14048975
70Sloping forehead (HP:0000340)2.11831942
71Triphalangeal thumb (HP:0001199)2.11117344
72Abnormal number of incisors (HP:0011064)2.10361013
73Muscle fiber atrophy (HP:0100295)2.10282163
74IgM deficiency (HP:0002850)2.07544200
75Trismus (HP:0000211)2.07201596
76Type 2 muscle fiber atrophy (HP:0003554)2.06947624
77Arteriovenous malformation (HP:0100026)2.04165025
78Sparse eyelashes (HP:0000653)2.03668190
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02617481
80Abnormality of alanine metabolism (HP:0010916)2.02617481
81Hyperalaninemia (HP:0003348)2.02617481
82Combined immunodeficiency (HP:0005387)2.02357204
83Duplication of thumb phalanx (HP:0009942)2.02196367
84Multiple enchondromatosis (HP:0005701)2.02054144
85Irregular epiphyses (HP:0010582)2.01835444
86Supernumerary spleens (HP:0009799)2.01579188
87Ragged-red muscle fibers (HP:0003200)2.00478390
88Abnormality of pyrimidine metabolism (HP:0004353)1.99382483
89Short thumb (HP:0009778)1.99001683
90Ependymoma (HP:0002888)1.95907457
91Abnormality of the renal collecting system (HP:0004742)1.94864212
92Abnormality of the carotid arteries (HP:0005344)1.93317528
93Acute lymphatic leukemia (HP:0006721)1.93315813
94Septate vagina (HP:0001153)1.92859695
95Choanal atresia (HP:0000453)1.92598967
96High pitched voice (HP:0001620)1.91747782
97Optic nerve coloboma (HP:0000588)1.91499140
98Ureteral duplication (HP:0000073)1.90758495
99High anterior hairline (HP:0009890)1.90210834
100Abnormality of homocysteine metabolism (HP:0010919)1.88263250
101Homocystinuria (HP:0002156)1.88263250
102Petechiae (HP:0000967)1.88152696
103Poor head control (HP:0002421)1.88044494
104Granulocytopenia (HP:0001913)1.88036243
105Abnormal spermatogenesis (HP:0008669)1.85989684
106Amaurosis fugax (HP:0100576)1.85690961
107Slender long bone (HP:0003100)1.85515160
108Abnormality of glycolysis (HP:0004366)1.85323375
109Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84695880
1103-Methylglutaconic aciduria (HP:0003535)1.84666752
111Progressive muscle weakness (HP:0003323)1.84268403
112Hypoplasia of the radius (HP:0002984)1.83611989
113Rectovaginal fistula (HP:0000143)1.83399158
114Rectal fistula (HP:0100590)1.83399158
115Abnormal protein N-linked glycosylation (HP:0012347)1.83124989
116Abnormal protein glycosylation (HP:0012346)1.83124989
117Abnormal glycosylation (HP:0012345)1.83124989
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83124989
119Abnormal mitochondria in muscle tissue (HP:0008316)1.82783388
120Increased serum lactate (HP:0002151)1.82437776
121Morphological abnormality of the inner ear (HP:0011390)1.81274002
122Proximal placement of thumb (HP:0009623)1.81192598
123Reduced antithrombin III activity (HP:0001976)1.80993425
124Atresia of the external auditory canal (HP:0000413)1.80414073
125Nephroblastoma (Wilms tumor) (HP:0002667)1.80280430
126Increased CSF lactate (HP:0002490)1.79488026
127Premature ovarian failure (HP:0008209)1.79206848
128Absent epiphyses (HP:0010577)1.78985496
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78985496
130Secondary amenorrhea (HP:0000869)1.78494116
131Hyperacusis (HP:0010780)1.78108984
132Testicular atrophy (HP:0000029)1.77461207
133Abnormality of reticulocytes (HP:0004312)1.75214501
134Increased serum pyruvate (HP:0003542)1.74765125
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73768538
136Abnormality of the labia minora (HP:0012880)1.73640585
137B lymphocytopenia (HP:0010976)1.73291077
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.72981146
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72230248
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72230248
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72010795
142Capillary hemangiomas (HP:0005306)1.71356105
143Acute encephalopathy (HP:0006846)1.66823883
144Severe combined immunodeficiency (HP:0004430)1.64950242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.35961685
2WEE14.27981294
3VRK24.26159410
4PLK44.06502721
5CDC73.79182254
6EIF2AK13.31148332
7PINK13.01627253
8SRPK12.94202699
9SMG12.76628235
10STK162.39855263
11EIF2AK32.27339411
12NME22.26759474
13NEK22.26018458
14TAF12.14487661
15VRK12.05878395
16BRSK22.05401872
17TTK1.92851785
18PLK11.92236352
19ACVR1B1.88663453
20NEK11.72294613
21ATR1.70752646
22TSSK61.68853513
23ZAK1.66022911
24CDK71.65730131
25MKNK11.57557290
26RPS6KB21.49596950
27BRSK11.48294684
28PIM21.47278755
29AURKB1.45394672
30TESK21.41601548
31PLK31.40566459
32PASK1.39294739
33RPS6KA41.25981538
34MKNK21.25221060
35CCNB11.24107804
36CHEK21.23213418
37TRIB31.21655085
38IRAK31.21509412
39STK41.15004494
40KDR1.14126466
41EPHA21.13121362
42DYRK31.12511650
43EIF2AK21.11294895
44STK101.11174524
45MAP4K11.10276666
46MAP3K81.09418841
47CDK41.07832652
48AURKA1.02345170
49ICK1.02205552
50TLK11.01640227
51PIM10.99369802
52CHEK10.98113596
53NUAK10.97172828
54IRAK40.87550062
55TGFBR10.85812683
56SCYL20.85706474
57PAK40.84220877
58FLT30.75640370
59AKT30.75033912
60ATM0.74384722
61CDK80.74231222
62CDK120.74154272
63CSNK2A10.71431309
64PBK0.68873022
65CDK20.68594226
66TYK20.66344082
67MAPK110.61908731
68TXK0.61744346
69BTK0.61660314
70TESK10.61411738
71CSNK2A20.60842288
72MAPKAPK30.60467784
73PNCK0.59926079
74MAP3K110.59255562
75IKBKB0.56810648
76LRRK20.56779432
77ALK0.55595026
78BRAF0.54547312
79JAK30.52833916
80EEF2K0.52194577
81BRD40.51870670
82CDK60.51864375
83TRIM280.51573854
84TAOK20.51555618
85CDK10.48397141
86PRKCI0.48342793
87TEC0.48133859
88MST40.47765226
89PDK20.47756943
90MAPKAPK50.46463030
91CDK190.46420786
92PAK10.46287168
93STK30.45681469
94CLK10.45670897
95RPS6KA50.45664644
96MAP2K30.45112443
97CDK90.44707751
98STK240.43798410
99YES10.42715688
100MTOR0.42365533
101NME10.41228339
102MAP3K100.40735517
103CDK11A0.40361530
104RAF10.39825619
105STK38L0.39588446
106KIT0.38546165
107AKT20.37709949
108PRKDC0.37685968
109MAP3K140.36210569
110CDK150.34503125
111CAMK1D0.34121553
112LYN0.32832403
113DYRK20.32437144
114BCKDK0.32094932
115ABL20.31510817
116MELK0.30637073
117CDK180.30447228
118CSF1R0.28765311
119CDK140.26772408
120INSRR0.26563150
121CHUK0.26201216
122NEK90.25803391
123CSNK1E0.25357666
124DAPK10.24656628
125MAPK140.24366143
126KSR20.23139824
127AKT10.22958788
128CDK30.22814167
129CSNK1G30.22529371
130IRAK20.21765513
131RPS6KA10.18752100

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.30920590
2Mismatch repair_Homo sapiens_hsa034304.34141585
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54799053
4Proteasome_Homo sapiens_hsa030503.49857897
5RNA polymerase_Homo sapiens_hsa030203.48688679
6Ribosome_Homo sapiens_hsa030103.34709203
7Homologous recombination_Homo sapiens_hsa034403.26543105
8Base excision repair_Homo sapiens_hsa034103.24183647
9Spliceosome_Homo sapiens_hsa030403.06801444
10Nucleotide excision repair_Homo sapiens_hsa034202.85001977
11* Pyrimidine metabolism_Homo sapiens_hsa002402.77355013
12RNA transport_Homo sapiens_hsa030132.73869587
13Cell cycle_Homo sapiens_hsa041102.51736086
14One carbon pool by folate_Homo sapiens_hsa006702.49348532
15Fanconi anemia pathway_Homo sapiens_hsa034602.35001946
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05697040
17Non-homologous end-joining_Homo sapiens_hsa034502.04532182
18RNA degradation_Homo sapiens_hsa030181.88628507
19Basal transcription factors_Homo sapiens_hsa030221.82996929
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71138474
21p53 signaling pathway_Homo sapiens_hsa041151.55981755
22* Purine metabolism_Homo sapiens_hsa002301.50888551
23mRNA surveillance pathway_Homo sapiens_hsa030151.27190315
24Epstein-Barr virus infection_Homo sapiens_hsa051691.24044780
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04375908
26Herpes simplex infection_Homo sapiens_hsa051681.03697216
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98400022
28Systemic lupus erythematosus_Homo sapiens_hsa053220.98030063
29Folate biosynthesis_Homo sapiens_hsa007900.90556266
30Antigen processing and presentation_Homo sapiens_hsa046120.89834005
31Drug metabolism - other enzymes_Homo sapiens_hsa009830.88112366
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87514004
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85714302
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.81388469
35Viral carcinogenesis_Homo sapiens_hsa052030.77880578
36Primary immunodeficiency_Homo sapiens_hsa053400.76749339
37Pyruvate metabolism_Homo sapiens_hsa006200.76101952
38Pentose phosphate pathway_Homo sapiens_hsa000300.75399585
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74811810
40Protein export_Homo sapiens_hsa030600.69686225
41Lysine degradation_Homo sapiens_hsa003100.68438041
42Bladder cancer_Homo sapiens_hsa052190.67980051
43Legionellosis_Homo sapiens_hsa051340.67908163
44Huntingtons disease_Homo sapiens_hsa050160.64628316
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.63766722
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63673855
47HTLV-I infection_Homo sapiens_hsa051660.62850216
48Biosynthesis of amino acids_Homo sapiens_hsa012300.62470317
49Glutathione metabolism_Homo sapiens_hsa004800.60771738
50Measles_Homo sapiens_hsa051620.60598419
51Vitamin B6 metabolism_Homo sapiens_hsa007500.59511030
52Selenocompound metabolism_Homo sapiens_hsa004500.59010182
53Oocyte meiosis_Homo sapiens_hsa041140.57908037
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55698115
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.53450233
56Parkinsons disease_Homo sapiens_hsa050120.53291398
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52606092
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50314895
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49938172
60Apoptosis_Homo sapiens_hsa042100.49874920
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49450795
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.48587985
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45724134
64Chronic myeloid leukemia_Homo sapiens_hsa052200.45679382
65N-Glycan biosynthesis_Homo sapiens_hsa005100.45006872
66Small cell lung cancer_Homo sapiens_hsa052220.44982540
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43703601
68Hematopoietic cell lineage_Homo sapiens_hsa046400.42411277
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.39714731
70Sulfur relay system_Homo sapiens_hsa041220.37718156
71Allograft rejection_Homo sapiens_hsa053300.37380306
72Fructose and mannose metabolism_Homo sapiens_hsa000510.37183667
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37079465
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36003469
75Alzheimers disease_Homo sapiens_hsa050100.35379168
76Influenza A_Homo sapiens_hsa051640.35261346
77Galactose metabolism_Homo sapiens_hsa000520.33146505
78Non-small cell lung cancer_Homo sapiens_hsa052230.32683293
79Hepatitis B_Homo sapiens_hsa051610.32455754
80Fatty acid elongation_Homo sapiens_hsa000620.32202743
81Arachidonic acid metabolism_Homo sapiens_hsa005900.32038134
82Pancreatic cancer_Homo sapiens_hsa052120.32019862
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31758065
84Asthma_Homo sapiens_hsa053100.31229733
85Thyroid cancer_Homo sapiens_hsa052160.30585560
86Graft-versus-host disease_Homo sapiens_hsa053320.30192108
87* Metabolic pathways_Homo sapiens_hsa011000.29569120
88Carbon metabolism_Homo sapiens_hsa012000.29325911
89Oxidative phosphorylation_Homo sapiens_hsa001900.29310916
90Shigellosis_Homo sapiens_hsa051310.27884142
91Leishmaniasis_Homo sapiens_hsa051400.26960819
92MicroRNAs in cancer_Homo sapiens_hsa052060.26620224
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24031445
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21539389
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21184493
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20363564
97Prostate cancer_Homo sapiens_hsa052150.19882282
98Other glycan degradation_Homo sapiens_hsa005110.18967931
99HIF-1 signaling pathway_Homo sapiens_hsa040660.18838460
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17855542
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17030709
102Propanoate metabolism_Homo sapiens_hsa006400.16991996
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.16877254
104Acute myeloid leukemia_Homo sapiens_hsa052210.16193874
105Renin-angiotensin system_Homo sapiens_hsa046140.15230659
106Basal cell carcinoma_Homo sapiens_hsa052170.14872294
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14848020
108Notch signaling pathway_Homo sapiens_hsa043300.14692993
109Steroid biosynthesis_Homo sapiens_hsa001000.14614875
110TGF-beta signaling pathway_Homo sapiens_hsa043500.13198174
111Alcoholism_Homo sapiens_hsa050340.12893280
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12657054
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12403277
114Autoimmune thyroid disease_Homo sapiens_hsa053200.11745003
115Colorectal cancer_Homo sapiens_hsa052100.11567672
116Melanoma_Homo sapiens_hsa052180.11299295
117Linoleic acid metabolism_Homo sapiens_hsa005910.10066282
118B cell receptor signaling pathway_Homo sapiens_hsa046620.09274087
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.08824591
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06072386
121Vitamin digestion and absorption_Homo sapiens_hsa049770.03701996
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.02249541

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »