PNRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.16549657
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28992858
3mitotic metaphase plate congression (GO:0007080)4.13344840
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98563798
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98563798
6metaphase plate congression (GO:0051310)3.93431729
7definitive hemopoiesis (GO:0060216)3.89675005
8ribosome assembly (GO:0042255)3.85010896
9DNA double-strand break processing (GO:0000729)3.84272914
10antigen processing and presentation of endogenous antigen (GO:0019883)3.82461345
11sister chromatid segregation (GO:0000819)3.81239566
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78735996
13regulation of mitotic spindle checkpoint (GO:1903504)3.78735996
14mitotic spindle checkpoint (GO:0071174)3.74356991
15spindle checkpoint (GO:0031577)3.68140546
16mitotic sister chromatid segregation (GO:0000070)3.66329144
17negative regulation of mitotic sister chromatid separation (GO:2000816)3.64358414
18negative regulation of sister chromatid segregation (GO:0033046)3.64358414
19negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64358414
20negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.64358414
21negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64358414
22positive regulation of gamma-delta T cell activation (GO:0046645)3.62516656
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61007294
24negative regulation of chromosome segregation (GO:0051985)3.58139856
25establishment of integrated proviral latency (GO:0075713)3.57304052
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57193841
27mitotic G2/M transition checkpoint (GO:0044818)3.53832258
28mitotic G2 DNA damage checkpoint (GO:0007095)3.52978925
29regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51359282
30regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51359282
31mitotic spindle assembly checkpoint (GO:0007094)3.50686427
32spindle assembly checkpoint (GO:0071173)3.48642590
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.45220490
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45220490
35regulation of mitotic sister chromatid separation (GO:0010965)3.43713708
36regulation of mitotic sister chromatid segregation (GO:0033047)3.43713708
37regulation of sister chromatid segregation (GO:0033045)3.43713708
38signal peptide processing (GO:0006465)3.43634362
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.39836637
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.39836637
41isotype switching (GO:0045190)3.39836637
42histone exchange (GO:0043486)3.37399564
43establishment of chromosome localization (GO:0051303)3.33423049
44kinetochore assembly (GO:0051382)3.29838276
45regulation of chromosome segregation (GO:0051983)3.29003031
46nuclear pore complex assembly (GO:0051292)3.27250509
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.25952548
48cellular response to zinc ion (GO:0071294)3.23584821
49nuclear pore organization (GO:0006999)3.19677801
50non-recombinational repair (GO:0000726)3.17622360
51double-strand break repair via nonhomologous end joining (GO:0006303)3.17622360
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11724202
53CENP-A containing nucleosome assembly (GO:0034080)3.11306674
54DNA topological change (GO:0006265)3.10637324
55transcription from mitochondrial promoter (GO:0006390)3.10626724
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10135557
57positive regulation of B cell differentiation (GO:0045579)3.09584672
58proteasome assembly (GO:0043248)3.08354783
59DNA catabolic process, exonucleolytic (GO:0000738)3.07394691
60hepatocyte apoptotic process (GO:0097284)3.05289545
61cotranslational protein targeting to membrane (GO:0006613)3.04867517
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04147534
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03899101
64telomere maintenance via semi-conservative replication (GO:0032201)3.02506812
65mitochondrial RNA metabolic process (GO:0000959)3.01793716
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.01307210
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01307210
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01307210
69protein targeting to ER (GO:0045047)3.00513089
70viral transcription (GO:0019083)2.98378972
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98232936
72purine nucleobase biosynthetic process (GO:0009113)2.98043580
73regulation of B cell differentiation (GO:0045577)2.97397814
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97257231
75negative regulation of phagocytosis (GO:0050765)2.96374423
76IMP biosynthetic process (GO:0006188)2.94358044
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92243072
78response to interferon-beta (GO:0035456)2.91975151
79negative regulation of DNA recombination (GO:0045910)2.91470919
80regulation of helicase activity (GO:0051095)2.91037938
81mitotic nuclear envelope disassembly (GO:0007077)2.91029214
82somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.89633997
83somatic cell DNA recombination (GO:0016444)2.89633997
84mitotic recombination (GO:0006312)2.89100127
85regulation of B cell receptor signaling pathway (GO:0050855)2.87996922
86positive regulation of histone H3-K4 methylation (GO:0051571)2.87719555
87platelet dense granule organization (GO:0060155)2.87529317
88somatic diversification of immune receptors (GO:0002200)2.87362920
89formation of translation preinitiation complex (GO:0001731)2.86225553
90polyketide metabolic process (GO:0030638)2.85164638
91doxorubicin metabolic process (GO:0044598)2.85164638
92daunorubicin metabolic process (GO:0044597)2.85164638
93establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84231049
94protein localization to endoplasmic reticulum (GO:0070972)2.83627641
95translational termination (GO:0006415)2.82092123
96mitochondrial DNA replication (GO:0006264)2.81300061
97intra-S DNA damage checkpoint (GO:0031573)2.81120536
98mitotic sister chromatid cohesion (GO:0007064)2.80232353
99regulation of sister chromatid cohesion (GO:0007063)2.79404966
100DNA replication-dependent nucleosome assembly (GO:0006335)2.79335032
101DNA replication-dependent nucleosome organization (GO:0034723)2.79335032
102chromatin remodeling at centromere (GO:0031055)2.78355384
103telomere maintenance via recombination (GO:0000722)2.78245376
104regulation of mitotic spindle organization (GO:0060236)2.78137881
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77173070
106COPI coating of Golgi vesicle (GO:0048205)2.75615912
107Golgi transport vesicle coating (GO:0048200)2.75615912
108termination of RNA polymerase II transcription (GO:0006369)2.75331572
109histone mRNA metabolic process (GO:0008334)2.74304811
110chromosome segregation (GO:0007059)2.72708337
111somatic recombination of immunoglobulin gene segments (GO:0016447)2.72395660
112somatic diversification of immunoglobulins (GO:0016445)2.71240130
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70450813
114negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.69733200
115megakaryocyte development (GO:0035855)2.68824340
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68613665
117negative regulation of ligase activity (GO:0051352)2.68613665
118negative regulation of mRNA processing (GO:0050686)2.67673689
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67038652
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66811241
121regulation of gamma-delta T cell differentiation (GO:0045586)2.66473495
122mismatch repair (GO:0006298)2.66100861
123translational elongation (GO:0006414)2.61792179
124DNA ligation (GO:0006266)2.58458767
125DNA strand elongation involved in DNA replication (GO:0006271)2.55829687
126attachment of spindle microtubules to kinetochore (GO:0008608)2.53681456
127DNA strand elongation (GO:0022616)2.53602392
128cellular response to interferon-beta (GO:0035458)2.53237878
129DNA unwinding involved in DNA replication (GO:0006268)2.53129474
130DNA replication-independent nucleosome assembly (GO:0006336)2.51201625
131DNA replication-independent nucleosome organization (GO:0034724)2.51201625
132regulation of gamma-delta T cell activation (GO:0046643)2.47773794
133secretory granule organization (GO:0033363)2.45693452
134kinetochore organization (GO:0051383)2.40549958
135valine metabolic process (GO:0006573)2.39750398
136T cell homeostasis (GO:0043029)2.39437230
137necroptotic process (GO:0070266)2.36776693
138nucleotide-excision repair, DNA gap filling (GO:0006297)2.36064504
139lymphoid progenitor cell differentiation (GO:0002320)2.35050202
140B cell receptor signaling pathway (GO:0050853)2.34918168
141dendritic cell chemotaxis (GO:0002407)2.31400373
142myeloid dendritic cell activation (GO:0001773)2.30584320
143viral life cycle (GO:0019058)2.29505228
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.22679898
145negative T cell selection (GO:0043383)2.22226537
146regulation of spindle organization (GO:0090224)2.21168597
147telomere maintenance via telomere lengthening (GO:0010833)2.20746010
148negative thymic T cell selection (GO:0045060)2.17138246
149leukocyte homeostasis (GO:0001776)2.16257371
150telomere organization (GO:0032200)2.15267790
151maturation of SSU-rRNA (GO:0030490)2.14392304
152ribosomal small subunit biogenesis (GO:0042274)2.14341735
153telomere maintenance (GO:0000723)2.14034053
154V(D)J recombination (GO:0033151)2.13834950
155* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.12601292
156lymphocyte homeostasis (GO:0002260)2.12365961
157meiotic chromosome segregation (GO:0045132)2.12042000
158protein localization to kinetochore (GO:0034501)2.11310253
159protein localization to chromosome, centromeric region (GO:0071459)2.11073698
160regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.10477903
161regulation of necroptotic process (GO:0060544)2.10346619
162antigen processing and presentation via MHC class Ib (GO:0002475)2.10157052
163regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.07937910
164T cell differentiation in thymus (GO:0033077)2.07467816
165positive regulation of interferon-alpha production (GO:0032727)2.07026097
166dendritic cell migration (GO:0036336)2.05670176
167embryonic hemopoiesis (GO:0035162)2.05192265
168positive regulation of T cell chemotaxis (GO:0010820)2.05167476
169regulation of T cell chemotaxis (GO:0010819)2.05167476
170translesion synthesis (GO:0019985)2.03382195
171NIK/NF-kappaB signaling (GO:0038061)2.03259165
172histamine secretion (GO:0001821)2.03055930
173lymph node development (GO:0048535)2.02618798
174* nuclear-transcribed mRNA catabolic process (GO:0000956)2.01657342
175response to interferon-alpha (GO:0035455)2.01283081
176angiogenesis involved in wound healing (GO:0060055)2.00523493
177regulation of T cell receptor signaling pathway (GO:0050856)2.00465996
178deoxyribonucleoside monophosphate metabolic process (GO:0009162)1.99458500
179cell differentiation involved in metanephros development (GO:0072202)1.99098840
180I-kappaB kinase/NF-kappaB signaling (GO:0007249)1.98771153
181regulation of B cell apoptotic process (GO:0002902)1.98641276
182response to type I interferon (GO:0034340)1.98226855
183production of molecular mediator involved in inflammatory response (GO:0002532)1.98223629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.96544200
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36604631
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.24826105
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21753695
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16240555
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99000392
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.91613890
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.66179214
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64526511
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57067588
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50828159
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49695234
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44022076
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43598100
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36493523
16GATA1_22025678_ChIP-Seq_K562_Human2.30267740
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22593888
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.20235806
19HOXB4_20404135_ChIP-ChIP_EML_Mouse2.20206303
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20138503
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.17417459
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.15861265
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.14556524
24SCL_19346495_ChIP-Seq_HPC-7_Human2.10904457
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09142450
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07837179
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06817813
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04537565
29ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02513068
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02371518
31ELK1_19687146_ChIP-ChIP_HELA_Human1.97409986
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93027410
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92443350
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90379644
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.87191792
36VDR_23849224_ChIP-Seq_CD4+_Human1.86849380
37SPI1_23547873_ChIP-Seq_NB4_Human1.85012473
38EWS_26573619_Chip-Seq_HEK293_Human1.82339724
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78026659
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76827170
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76498891
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75210774
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74930512
44* MYB_26560356_Chip-Seq_TH2_Human1.74240987
45FOXP3_21729870_ChIP-Seq_TREG_Human1.71877696
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70678735
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68690666
48IGF1R_20145208_ChIP-Seq_DFB_Human1.67057848
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63316805
50MYC_22102868_ChIP-Seq_BL_Human1.63283033
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62082530
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57043657
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55704651
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.54231220
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53905225
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53705463
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51819574
58* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51748211
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50973869
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.50242296
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48566666
62* CIITA_25753668_ChIP-Seq_RAJI_Human1.48158831
63FUS_26573619_Chip-Seq_HEK293_Human1.47267197
64AR_21909140_ChIP-Seq_LNCAP_Human1.46869853
65RUNX_20019798_ChIP-Seq_JUKART_Human1.46833757
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46652604
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45887681
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45130715
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44721474
70DCP1A_22483619_ChIP-Seq_HELA_Human1.42965342
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41898762
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40210172
73* MYB_26560356_Chip-Seq_TH1_Human1.39781319
74* IRF8_27001747_Chip-Seq_BMDM_Mouse1.39282990
75* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37775958
76* XRN2_22483619_ChIP-Seq_HELA_Human1.37734110
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.32613864
78* MAF_26560356_Chip-Seq_TH1_Human1.32061726
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.32031957
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30572118
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28084528
82VDR_21846776_ChIP-Seq_THP-1_Human1.27927676
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27222607
84* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24882454
85ZNF274_21170338_ChIP-Seq_K562_Hela1.24401761
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.24296880
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23968244
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22662837
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19823019
90MYC_18940864_ChIP-ChIP_HL60_Human1.19411239
91TAF15_26573619_Chip-Seq_HEK293_Human1.16990168
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16867529
93CLOCK_20551151_ChIP-Seq_293T_Human1.16216082
94VDR_24763502_ChIP-Seq_THP-1_Human1.16047061
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15237795
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14423364
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13872751
98* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13650523
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13645720
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13310720
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12867330
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12541745
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11563199
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11513538
105* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11463571
106TFEB_21752829_ChIP-Seq_HELA_Human1.10921253
107GABP_19822575_ChIP-Seq_HepG2_Human1.10186000
108* UTX_26944678_Chip-Seq_JUKART_Human1.09909031
109KDM5A_27292631_Chip-Seq_BREAST_Human1.09310772
110VDR_22108803_ChIP-Seq_LS180_Human1.07842327
111* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06723634
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05112976
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04097889
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03938947
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03442919
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02708949
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02242635
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00811827
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99211837
120IRF1_19129219_ChIP-ChIP_H3396_Human0.98808175
121BP1_19119308_ChIP-ChIP_Hs578T_Human0.98486550
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98341630
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97480311
124* TTF2_22483619_ChIP-Seq_HELA_Human0.97469794
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96117371
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95760974
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94728387
128SALL4_22934838_ChIP-ChIP_CD34+_Human0.93089712
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92961228
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89121524
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.88394951
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85073257
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.84892884
134* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83507998
135* GATA3_26560356_Chip-Seq_TH2_Human0.81239340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.72386747
2MP0001835_abnormal_antigen_presentation3.03776822
3MP0005671_abnormal_response_to2.44135140
4MP0002166_altered_tumor_susceptibility2.42147014
5MP0002396_abnormal_hematopoietic_system2.41013451
6MP0000685_abnormal_immune_system2.35753036
7MP0003763_abnormal_thymus_physiology2.22836782
8MP0008932_abnormal_embryonic_tissue2.16221289
9MP0009785_altered_susceptibility_to2.14608881
10MP0008007_abnormal_cellular_replicative2.02350079
11MP0008877_abnormal_DNA_methylation1.99351810
12MP0001800_abnormal_humoral_immune1.98608181
13MP0002009_preneoplasia1.92325428
14MP0006072_abnormal_retinal_apoptosis1.91403501
15MP0001879_abnormal_lymphatic_vessel1.83892692
16MP0008995_early_reproductive_senescence1.83784699
17MP0003786_premature_aging1.83571248
18MP0002452_abnormal_antigen_presenting1.81312238
19MP0004147_increased_porphyrin_level1.75052313
20MP0002398_abnormal_bone_marrow1.74976970
21MP0002420_abnormal_adaptive_immunity1.72751451
22MP0005000_abnormal_immune_tolerance1.72739066
23MP0004808_abnormal_hematopoietic_stem1.72346245
24MP0002006_tumorigenesis1.71691243
25MP0002148_abnormal_hypersensitivity_rea1.70335169
26MP0003724_increased_susceptibility_to1.68960781
27MP0001819_abnormal_immune_cell1.68921349
28MP0005025_abnormal_response_to1.67388555
29MP0001853_heart_inflammation1.64100190
30MP0002723_abnormal_immune_serum1.60974127
31MP0010155_abnormal_intestine_physiology1.57381173
32MP0001790_abnormal_immune_system1.56410442
33MP0005387_immune_system_phenotype1.56410442
34MP0003221_abnormal_cardiomyocyte_apopto1.55707316
35MP0003806_abnormal_nucleotide_metabolis1.54701638
36MP0003436_decreased_susceptibility_to1.54318080
37MP0006292_abnormal_olfactory_placode1.53366869
38MP0009333_abnormal_splenocyte_physiolog1.52951335
39MP0000490_abnormal_crypts_of1.52784960
40MP0002419_abnormal_innate_immunity1.52726381
41MP0000716_abnormal_immune_system1.51735383
42MP0000689_abnormal_spleen_morphology1.51038504
43MP0010307_abnormal_tumor_latency1.50421159
44MP0003718_maternal_effect1.48465799
45MP0003077_abnormal_cell_cycle1.47991356
46MP0003943_abnormal_hepatobiliary_system1.47070662
47MP0005464_abnormal_platelet_physiology1.46324181
48MP0003890_abnormal_embryonic-extraembry1.46317660
49MP0002722_abnormal_immune_system1.45342634
50MP0003693_abnormal_embryo_hatching1.41830524
51MP0002429_abnormal_blood_cell1.41647951
52MP0000465_gastrointestinal_hemorrhage1.41117512
53MP0001730_embryonic_growth_arrest1.40930293
54MP0002132_abnormal_respiratory_system1.40382505
55MP0001727_abnormal_embryo_implantation1.40295585
56MP0010368_abnormal_lymphatic_system1.39672414
57MP0008438_abnormal_cutaneous_collagen1.38874448
58MP0001293_anophthalmia1.35545307
59MP0010094_abnormal_chromosome_stability1.35312721
60MP0002405_respiratory_system_inflammati1.33835971
61MP0006035_abnormal_mitochondrial_morpho1.33704766
62MP0006036_abnormal_mitochondrial_physio1.32244740
63MP0003186_abnormal_redox_activity1.31071668
64MP0001764_abnormal_homeostasis1.26153606
65MP0008057_abnormal_DNA_replication1.25712458
66MP0001545_abnormal_hematopoietic_system1.21420933
67MP0005397_hematopoietic_system_phenotyp1.21420933
68MP0001672_abnormal_embryogenesis/_devel1.21349943
69MP0005380_embryogenesis_phenotype1.21349943
70MP0008058_abnormal_DNA_repair1.21269847
71MP0001873_stomach_inflammation1.21095710
72MP0001845_abnormal_inflammatory_respons1.20917819
73MP0000703_abnormal_thymus_morphology1.20482032
74MP0009697_abnormal_copulation1.20212209
75MP0005253_abnormal_eye_physiology1.12746143
76MP0004957_abnormal_blastocyst_morpholog1.10911972
77MP0009384_cardiac_valve_regurgitation1.09666636
78MP0000858_altered_metastatic_potential1.09362119
79MP0003300_gastrointestinal_ulcer1.09203978
80MP0001697_abnormal_embryo_size1.08823581
81MP0001529_abnormal_vocalization1.08175361
82MP0003279_aneurysm1.07074562
83MP0008789_abnormal_olfactory_epithelium1.06203592
84MP0003984_embryonic_growth_retardation1.06161587
85MP0000372_irregular_coat_pigmentation1.04112827
86MP0002088_abnormal_embryonic_growth/wei1.03855358
87MP0000343_altered_response_to1.01663609
88MP0005503_abnormal_tendon_morphology1.01481843
89MP0000516_abnormal_urinary_system1.01225504
90MP0005367_renal/urinary_system_phenotyp1.01225504
91MP0003787_abnormal_imprinting0.99905405
92MP0002102_abnormal_ear_morphology0.99675221
93MP0003941_abnormal_skin_development0.99402291
94MP0008469_abnormal_protein_level0.97806957
95MP0001915_intracranial_hemorrhage0.96391671
96MP0002933_joint_inflammation0.94995732
97MP0002080_prenatal_lethality0.94782528
98MP0002019_abnormal_tumor_incidence0.94077685
99MP0003567_abnormal_fetal_cardiomyocyte0.91936019
100MP0005248_abnormal_Harderian_gland0.90097134
101MP0005275_abnormal_skin_tensile0.88653896
102MP0001533_abnormal_skeleton_physiology0.88257839
103MP0003656_abnormal_erythrocyte_physiolo0.87704159
104MP0000358_abnormal_cell_content/0.86814059
105MP0006082_CNS_inflammation0.86801351
106MP0005220_abnormal_exocrine_pancreas0.86355620
107MP0003866_abnormal_defecation0.86163807
108MP0001929_abnormal_gametogenesis0.85254787
109MP0002090_abnormal_vision0.84991961
110MP0004947_skin_inflammation0.84442791
111MP0002095_abnormal_skin_pigmentation0.84075463
112MP0003111_abnormal_nucleus_morphology0.83859666
113MP0004264_abnormal_extraembryonic_tissu0.83399349
114MP0005023_abnormal_wound_healing0.82706918
115MP0002138_abnormal_hepatobiliary_system0.81063304
116MP0002086_abnormal_extraembryonic_tissu0.79448663
117MP0004197_abnormal_fetal_growth/weight/0.79315580
118MP0002938_white_spotting0.78473363
119MP0010352_gastrointestinal_tract_polyps0.77113875
120MP0003828_pulmonary_edema0.76563855
121MP0001119_abnormal_female_reproductive0.75701038
122MP0003195_calcinosis0.75553587
123MP0002928_abnormal_bile_duct0.75421315
124MP0005058_abnormal_lysosome_morphology0.74876849
125MP0002751_abnormal_autonomic_nervous0.74407557
126MP0005075_abnormal_melanosome_morpholog0.74349160
127MP0002084_abnormal_developmental_patter0.72940649
128MP0001243_abnormal_dermal_layer0.70591734
129MP0000313_abnormal_cell_death0.69853204
130MP0000767_abnormal_smooth_muscle0.69581264
131MP0005174_abnormal_tail_pigmentation0.69400795
132MP0003191_abnormal_cellular_cholesterol0.69151016
133MP0000598_abnormal_liver_morphology0.68649454
134MP0000350_abnormal_cell_proliferation0.68336993
135MP0000249_abnormal_blood_vessel0.68007534
136MP0009278_abnormal_bone_marrow0.67798624
137MP0004782_abnormal_surfactant_physiolog0.67166075
138MP0009643_abnormal_urine_homeostasis0.67100605
139MP0009764_decreased_sensitivity_to0.67085572
140MP0005084_abnormal_gallbladder_morpholo0.66976102
141MP0000477_abnormal_intestine_morphology0.66736084
142MP0009763_increased_sensitivity_to0.66175923
143MP0002060_abnormal_skin_morphology0.65594977

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)3.63087082
2IgM deficiency (HP:0002850)3.50282071
3Chronic otitis media (HP:0000389)3.46382435
4Elevated erythrocyte sedimentation rate (HP:0003565)3.18403561
5Gastrointestinal stroma tumor (HP:0100723)3.15375742
6Aplastic anemia (HP:0001915)3.06273354
7Recurrent abscess formation (HP:0002722)3.05798887
8Recurrent bronchitis (HP:0002837)2.98766407
9Agammaglobulinemia (HP:0004432)2.96355353
10Medulloblastoma (HP:0002885)2.87310627
11Myositis (HP:0100614)2.86061604
12Recurrent bacterial skin infections (HP:0005406)2.78658352
13Stomach cancer (HP:0012126)2.77830196
14Recurrent viral infections (HP:0004429)2.70253096
15Lipid accumulation in hepatocytes (HP:0006561)2.70080159
16Volvulus (HP:0002580)2.70002302
17T lymphocytopenia (HP:0005403)2.68785165
18Abnormality of T cell number (HP:0011839)2.64965931
19Increased hepatocellular lipid droplets (HP:0006565)2.63070465
20Petechiae (HP:0000967)2.61466406
21Hematochezia (HP:0002573)2.60312960
22Lymphopenia (HP:0001888)2.58976032
23Cellulitis (HP:0100658)2.58514497
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.56938737
25Abnormal number of erythroid precursors (HP:0012131)2.55971175
26Abnormality of T cells (HP:0002843)2.53267775
27Reticulocytopenia (HP:0001896)2.52722470
28Rhabdomyosarcoma (HP:0002859)2.52069511
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.50134412
30Thyroid carcinoma (HP:0002890)2.48579347
31Neoplasm of the colon (HP:0100273)2.47394291
32Gonadotropin excess (HP:0000837)2.44062193
33Abnormality of chromosome stability (HP:0003220)2.43910757
34Abnormal lung lobation (HP:0002101)2.43698452
35Abnormality of cells of the erythroid lineage (HP:0012130)2.41980660
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41757589
37Abnormality of the labia minora (HP:0012880)2.41735304
38Microvesicular hepatic steatosis (HP:0001414)2.41055259
39Type I transferrin isoform profile (HP:0003642)2.40578594
40Neoplasm of the adrenal gland (HP:0100631)2.40466365
41Ovarian neoplasm (HP:0100615)2.39381976
42Nephroblastoma (Wilms tumor) (HP:0002667)2.38715876
43Dyschromatopsia (HP:0007641)2.38556682
44Abnormality of methionine metabolism (HP:0010901)2.38205922
45Abnormality of T cell physiology (HP:0011840)2.38086934
4611 pairs of ribs (HP:0000878)2.34566378
47Vacuolated lymphocytes (HP:0001922)2.34386612
48IgG deficiency (HP:0004315)2.33507470
49Embryonal renal neoplasm (HP:0011794)2.33241764
50Methylmalonic acidemia (HP:0002912)2.29809886
51Hyperglycinuria (HP:0003108)2.28617227
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28460702
53Glioma (HP:0009733)2.27643052
54Cortical dysplasia (HP:0002539)2.27311475
55Spondylolisthesis (HP:0003302)2.25713612
56Hyperglycinemia (HP:0002154)2.25622319
57Abnormality of the anterior horn cell (HP:0006802)2.24429650
58Degeneration of anterior horn cells (HP:0002398)2.24429650
59Reduced antithrombin III activity (HP:0001976)2.24206142
60Lymphoma (HP:0002665)2.22069278
61Nonimmune hydrops fetalis (HP:0001790)2.22048851
62Myelodysplasia (HP:0002863)2.19919389
63Biconcave vertebral bodies (HP:0004586)2.19736402
64Carpal bone hypoplasia (HP:0001498)2.18881372
65Breast carcinoma (HP:0003002)2.16183837
66Ependymoma (HP:0002888)2.16167279
67Colon cancer (HP:0003003)2.15482685
68Central scotoma (HP:0000603)2.12705616
69Meningitis (HP:0001287)2.12460932
70Chromsome breakage (HP:0040012)2.09528323
71IgA deficiency (HP:0002720)2.09394306
72Spontaneous hematomas (HP:0007420)2.09273908
73Neoplasm of the small intestine (HP:0100833)2.08915891
74Papillary thyroid carcinoma (HP:0002895)2.06300645
75Chronic diarrhea (HP:0002028)2.05626403
76Acute myeloid leukemia (HP:0004808)2.05202416
77Osteomyelitis (HP:0002754)2.05044577
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.04577203
79Abnormality of male internal genitalia (HP:0000022)2.04027670
80Biliary tract neoplasm (HP:0100574)2.02870761
81Abnormality of serum amino acid levels (HP:0003112)2.01683097
82Panhypogammaglobulinemia (HP:0003139)2.01571568
83Abnormality of serine family amino acid metabolism (HP:0010894)2.00821717
84Abnormality of glycine metabolism (HP:0010895)2.00821717
85Generalized aminoaciduria (HP:0002909)1.99993105
86Progressive external ophthalmoplegia (HP:0000590)1.97615607
87Recurrent skin infections (HP:0001581)1.96247350
88Aortic aneurysm (HP:0004942)1.96106158
89Autoimmune hemolytic anemia (HP:0001890)1.95980313
90Broad face (HP:0000283)1.94883508
91Abnormal protein glycosylation (HP:0012346)1.93522789
92Abnormal glycosylation (HP:0012345)1.93522789
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93522789
94Abnormal protein N-linked glycosylation (HP:0012347)1.93522789
95Abnormality of the prostate (HP:0008775)1.93398582
96Eczematoid dermatitis (HP:0000976)1.92072407
97Cutaneous melanoma (HP:0012056)1.91600887
98Prolonged bleeding time (HP:0003010)1.90983487
99Sloping forehead (HP:0000340)1.90835829
100Abnormality of vitamin B metabolism (HP:0004340)1.90398253
1013-Methylglutaconic aciduria (HP:0003535)1.90084023
102Short middle phalanx of the 5th finger (HP:0004220)1.89674973
103Intestinal atresia (HP:0011100)1.88786845
104Cystic hygroma (HP:0000476)1.87546610
105Basal cell carcinoma (HP:0002671)1.87532128
106Median cleft lip (HP:0000161)1.86543060
107Hypoplasia of the thymus (HP:0000778)1.86180602
108Abnormality of the vitamin B12 metabolism (HP:0004341)1.86104035
109Thyroiditis (HP:0100646)1.85931398
110Recurrent fungal infections (HP:0002841)1.85815815
111Agnosia (HP:0010524)1.85333013
112Meckel diverticulum (HP:0002245)1.83318636
113Abnormality of B cell number (HP:0010975)1.82812524
114B lymphocytopenia (HP:0010976)1.82812524
115Onycholysis (HP:0001806)1.82691971
116Limb hypertonia (HP:0002509)1.82682404
117Neutropenia (HP:0001875)1.80952648
118Gastrointestinal inflammation (HP:0004386)1.80406667
119Posterior subcapsular cataract (HP:0007787)1.80308861
120Aortic valve stenosis (HP:0001650)1.80166774
121Abnormality of macular pigmentation (HP:0008002)1.79849960
122Spinal cord lesions (HP:0100561)1.79834606
123Syringomyelia (HP:0003396)1.79834606
124Mediastinal lymphadenopathy (HP:0100721)1.79500421
125Palpitations (HP:0001962)1.78832655
126Vasculitis (HP:0002633)1.78814934
127Encephalitis (HP:0002383)1.78772708
128Colitis (HP:0002583)1.78707879
129Methylmalonic aciduria (HP:0012120)1.78564263
130Curly hair (HP:0002212)1.78246539
131Epistaxis (HP:0000421)1.77895299
132Inflammation of the large intestine (HP:0002037)1.77886871
133Emphysema (HP:0002097)1.77755176
134Papilloma (HP:0012740)1.77487340
135Verrucae (HP:0200043)1.77487340
136Pancreatic islet-cell hyperplasia (HP:0004510)1.77013684
137Short 4th metacarpal (HP:0010044)1.76631291
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76631291
139Increased serum lactate (HP:0002151)1.75668372
140Periodontitis (HP:0000704)1.75385361
141Autoimmune thrombocytopenia (HP:0001973)1.74901163
142Microretrognathia (HP:0000308)1.74849073
143Prostate neoplasm (HP:0100787)1.73935718
144Severe combined immunodeficiency (HP:0004430)1.73531978
145Small intestinal stenosis (HP:0012848)1.72964446
146Duodenal stenosis (HP:0100867)1.72964446
147Abnormality of endocrine pancreas physiology (HP:0012093)1.72821077
148Abnormality of the pancreatic islet cells (HP:0006476)1.72821077
149Abnormality of homocysteine metabolism (HP:0010919)1.72804699
150Homocystinuria (HP:0002156)1.72804699
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72788586
152Neuroendocrine neoplasm (HP:0100634)1.71819609
153Orchitis (HP:0100796)1.71770831
154Recurrent sinusitis (HP:0011108)1.70826240
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.70611739
156Abnormal spermatogenesis (HP:0008669)1.70535357
157Combined immunodeficiency (HP:0005387)1.70403434
158Increased serum pyruvate (HP:0003542)1.69941999
159Abnormal biliary tract physiology (HP:0012439)1.69908653
160Bile duct proliferation (HP:0001408)1.69908653
161Abnormality of the ileum (HP:0001549)1.69901855
162Abnormality of eosinophils (HP:0001879)1.67803365
163Meningioma (HP:0002858)1.67543586
164Acanthocytosis (HP:0001927)1.67457197
165Impaired platelet aggregation (HP:0003540)1.66623702
166Abnormal platelet function (HP:0011869)1.66623702
167Bicuspid aortic valve (HP:0001647)1.66515809
168Skin ulcer (HP:0200042)1.66454405
169Granulocytopenia (HP:0001913)1.65028776
170Recurrent pneumonia (HP:0006532)1.64811929
171Amaurosis fugax (HP:0100576)1.64204816
172Abnormality of macrophages (HP:0004311)1.63991602
173Mucosal telangiectasiae (HP:0100579)1.62746387
174Aortic dissection (HP:0002647)1.62456137
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62245123
176Skin rash (HP:0000988)1.61999151
177Keratoconjunctivitis sicca (HP:0001097)1.60841267
178Interstitial pulmonary disease (HP:0006530)1.60213011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B2.90850957
2TGFBR12.90376746
3NEK12.89886598
4TTK2.69781091
5MAP4K22.47465749
6TSSK62.37799885
7MAP4K12.37627191
8FLT32.29198294
9TGFBR22.23013022
10TEC2.19226320
11KIT2.14487763
12TRIM282.08017181
13PLK32.01278290
14BCR2.00851363
15STK101.96568853
16IRAK41.91400308
17RPS6KA41.83511952
18TYK21.82548846
19FRK1.82210232
20MST41.81025056
21PASK1.80125201
22NEK91.79190239
23CDK191.76260001
24ITK1.75886308
25BUB11.74830111
26BTK1.74140891
27MAP3K141.69517404
28TXK1.68794952
29JAK31.62383764
30CSF1R1.52375703
31LRRK21.50124333
32MKNK11.49868707
33BRSK21.48247432
34TBK11.45423251
35DYRK31.44357753
36STK161.41067744
37BMPR1B1.40757888
38TAF11.40101937
39NUAK11.37845688
40NME21.37493826
41TIE11.36975247
42BRD41.36369719
43SIK31.35361700
44SRPK11.31383096
45KDR1.30637723
46IKBKE1.26961904
47ERN11.25670274
48PIK3CG1.24563892
49CLK11.24440936
50EIF2AK11.23077972
51VRK21.22435121
52STK41.18194677
53STK31.18158217
54NLK1.17955862
55BCKDK1.14674171
56ZAP701.10113099
57VRK11.08830378
58IKBKB1.08787560
59MELK1.06225070
60PLK11.06016215
61BMPR21.05869628
62TAOK31.04416474
63CDK81.01963356
64PIM21.01541170
65WNK31.00210882
66FGFR30.97160769
67PIM10.97038278
68WEE10.94931175
69CHUK0.94347062
70MAP2K30.92629919
71ERBB30.92316047
72JAK10.88524229
73PLK20.85504001
74EIF2AK30.85191282
75AURKB0.85185343
76LYN0.83520728
77ZAK0.80361413
78LCK0.77301129
79MYLK0.77172635
80EIF2AK20.76155627
81SCYL20.75277261
82NEK20.72465620
83PAK40.72054264
84CDK60.70986224
85CDK90.70861994
86MAP3K40.70252795
87IRAK30.70132321
88YES10.69777666
89CSNK1G30.69495666
90SYK0.68757945
91MAP3K100.68032299
92PBK0.67732372
93CDC70.67637593
94ATR0.66974525
95RPS6KB20.66777290
96FGFR40.65718525
97CSNK1G20.64024360
98PTK60.63941164
99CHEK20.63875570
100MAPK110.62999601
101CSNK1G10.62554558
102MATK0.61586365
103PKN20.61027209
104ATM0.59852537
105PLK40.59208156
106BLK0.56874379
107CSNK1A1L0.55971713
108EPHA30.55931675
109MKNK20.54540144
110PIK3CA0.52960498
111ALK0.52366188
112TRPM70.50665351
113CSK0.49120134
114RAF10.49120098
115GRK60.48879889
116BRSK10.48603323
117DYRK1B0.48278626
118STK38L0.47997319
119CDK40.47848478
120CCNB10.47077119
121CHEK10.46583292
122TRIB30.46303461
123MAPKAPK20.46208970
124MAP3K80.44863152
125IGF1R0.44689336
126RPS6KA60.43996061
127TNIK0.43106801
128EEF2K0.42590479
129HIPK20.42044934
130IRAK10.41833408
131CDK30.37672840
132CSNK2A10.37494082
133OXSR10.35009911
134STK240.32938582
135MAP3K50.32606575
136RPS6KA50.30007665
137MARK30.29279321
138EGFR0.29185267
139CSNK2A20.29068280
140PRKCQ0.28989840

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.14732974
2Base excision repair_Homo sapiens_hsa034102.78098835
3Protein export_Homo sapiens_hsa030602.61884944
4Mismatch repair_Homo sapiens_hsa034302.56664933
5Ribosome_Homo sapiens_hsa030102.49906419
6Primary immunodeficiency_Homo sapiens_hsa053402.40419311
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20837203
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02278579
9Antigen processing and presentation_Homo sapiens_hsa046121.91783428
10Non-homologous end-joining_Homo sapiens_hsa034501.89886027
11Homologous recombination_Homo sapiens_hsa034401.79846324
12Spliceosome_Homo sapiens_hsa030401.69533957
13Nucleotide excision repair_Homo sapiens_hsa034201.68899384
14Asthma_Homo sapiens_hsa053101.67091026
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.66293490
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61635509
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.58994202
18Measles_Homo sapiens_hsa051621.58462661
19Cell cycle_Homo sapiens_hsa041101.57584161
20Herpes simplex infection_Homo sapiens_hsa051681.53557083
21Legionellosis_Homo sapiens_hsa051341.52533944
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48547526
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42745690
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.42146385
25Fatty acid elongation_Homo sapiens_hsa000621.39029127
26Leishmaniasis_Homo sapiens_hsa051401.38398875
27Proteasome_Homo sapiens_hsa030501.37805480
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36349111
29B cell receptor signaling pathway_Homo sapiens_hsa046621.35477557
30Type I diabetes mellitus_Homo sapiens_hsa049401.32892960
31Hematopoietic cell lineage_Homo sapiens_hsa046401.31166219
32RNA degradation_Homo sapiens_hsa030181.26342159
33Caffeine metabolism_Homo sapiens_hsa002321.25948358
34Pyrimidine metabolism_Homo sapiens_hsa002401.20838246
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17863748
36p53 signaling pathway_Homo sapiens_hsa041151.12338039
37Butanoate metabolism_Homo sapiens_hsa006501.12106519
38Systemic lupus erythematosus_Homo sapiens_hsa053221.10963773
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10572563
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09819355
41Selenocompound metabolism_Homo sapiens_hsa004501.07602894
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07292301
43Steroid biosynthesis_Homo sapiens_hsa001001.06033305
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.03991669
45N-Glycan biosynthesis_Homo sapiens_hsa005101.03294135
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03216403
47Malaria_Homo sapiens_hsa051441.00827891
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00520083
49Small cell lung cancer_Homo sapiens_hsa052220.98830207
50Toxoplasmosis_Homo sapiens_hsa051450.98367186
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.97973633
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96596870
53Oocyte meiosis_Homo sapiens_hsa041140.95095659
54Viral carcinogenesis_Homo sapiens_hsa052030.92269727
55Apoptosis_Homo sapiens_hsa042100.90853886
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90139889
57Purine metabolism_Homo sapiens_hsa002300.90046816
58RNA polymerase_Homo sapiens_hsa030200.89595845
59Allograft rejection_Homo sapiens_hsa053300.88384140
60Influenza A_Homo sapiens_hsa051640.87525160
61Osteoclast differentiation_Homo sapiens_hsa043800.87176439
62Fanconi anemia pathway_Homo sapiens_hsa034600.86833347
63One carbon pool by folate_Homo sapiens_hsa006700.86489694
64Hepatitis B_Homo sapiens_hsa051610.86025090
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85700087
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85349511
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82846686
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82551235
69Epstein-Barr virus infection_Homo sapiens_hsa051690.82257519
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.81193066
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80623608
72Other glycan degradation_Homo sapiens_hsa005110.79852675
73RNA transport_Homo sapiens_hsa030130.79842224
74Basal transcription factors_Homo sapiens_hsa030220.79592477
75HTLV-I infection_Homo sapiens_hsa051660.78297467
76Peroxisome_Homo sapiens_hsa041460.77473818
77Sulfur metabolism_Homo sapiens_hsa009200.76882568
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76354679
79Pancreatic cancer_Homo sapiens_hsa052120.75688129
80Viral myocarditis_Homo sapiens_hsa054160.75672314
81Fatty acid degradation_Homo sapiens_hsa000710.73706822
82Thyroid cancer_Homo sapiens_hsa052160.72166272
83Shigellosis_Homo sapiens_hsa051310.72127102
84Carbon metabolism_Homo sapiens_hsa012000.72031193
85Folate biosynthesis_Homo sapiens_hsa007900.71592136
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71173480
87T cell receptor signaling pathway_Homo sapiens_hsa046600.70952754
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70678889
89Pyruvate metabolism_Homo sapiens_hsa006200.70322610
90Hepatitis C_Homo sapiens_hsa051600.68400427
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.67992669
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67752215
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67119730
94TNF signaling pathway_Homo sapiens_hsa046680.66040256
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65436355
96Graft-versus-host disease_Homo sapiens_hsa053320.65029234
97Platelet activation_Homo sapiens_hsa046110.65010732
98Propanoate metabolism_Homo sapiens_hsa006400.64593604
99Pertussis_Homo sapiens_hsa051330.63985739
100Acute myeloid leukemia_Homo sapiens_hsa052210.63669521
101Staphylococcus aureus infection_Homo sapiens_hsa051500.63531459
102Chronic myeloid leukemia_Homo sapiens_hsa052200.62564678
103Glutathione metabolism_Homo sapiens_hsa004800.61147409
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.60931180
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58984630
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57342188
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56354532
108Vitamin digestion and absorption_Homo sapiens_hsa049770.55769432
109Fatty acid metabolism_Homo sapiens_hsa012120.54962090
110Notch signaling pathway_Homo sapiens_hsa043300.53514570
111Sulfur relay system_Homo sapiens_hsa041220.51743926
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50538914
113Parkinsons disease_Homo sapiens_hsa050120.50361796
114Pentose phosphate pathway_Homo sapiens_hsa000300.49669797
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49408242
116Autoimmune thyroid disease_Homo sapiens_hsa053200.48745046
117Colorectal cancer_Homo sapiens_hsa052100.48440896
118mRNA surveillance pathway_Homo sapiens_hsa030150.48316292
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47787995
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47495485
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46264184
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46069581
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46046437
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45604946
125Nitrogen metabolism_Homo sapiens_hsa009100.45310926
126Lysosome_Homo sapiens_hsa041420.45288779
127Biosynthesis of amino acids_Homo sapiens_hsa012300.45186296
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44283690
129Tryptophan metabolism_Homo sapiens_hsa003800.36283742
130Regulation of autophagy_Homo sapiens_hsa041400.34559206
131Rheumatoid arthritis_Homo sapiens_hsa053230.32082670
132Metabolic pathways_Homo sapiens_hsa011000.31655752
133Oxidative phosphorylation_Homo sapiens_hsa001900.26921139
134Vitamin B6 metabolism_Homo sapiens_hsa007500.22438933
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21605893

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