PNMA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorders are the result of an abnormal immune response to a tumor. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1generation of neurons (GO:0048699)9.40342122
2segment specification (GO:0007379)7.51382121
3myoblast migration (GO:0051451)7.44376361
4proximal/distal pattern formation (GO:0009954)7.03516409
5negative regulation of catenin import into nucleus (GO:0035414)6.53529574
6cranial nerve morphogenesis (GO:0021602)6.03485856
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.85674614
8nephron tubule formation (GO:0072079)5.41412881
9organ induction (GO:0001759)5.37252604
10positive regulation of vesicle fusion (GO:0031340)5.32372497
11planar cell polarity pathway involved in neural tube closure (GO:0090179)5.30657464
12mitotic metaphase plate congression (GO:0007080)5.30376639
13tachykinin receptor signaling pathway (GO:0007217)5.26421914
14mitotic sister chromatid segregation (GO:0000070)5.18180159
15embryonic skeletal joint morphogenesis (GO:0060272)5.13037627
16protein localization to kinetochore (GO:0034501)5.08597300
17regulation of cardioblast proliferation (GO:0003264)4.86828368
18regulation of secondary heart field cardioblast proliferation (GO:0003266)4.86828368
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.83606153
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.81073625
21appendage development (GO:0048736)4.74619008
22limb development (GO:0060173)4.74619008
23negative regulation of kidney development (GO:0090185)4.53726661
24nuclear pore organization (GO:0006999)4.53645658
25neuron fate specification (GO:0048665)4.52365372
26DNA replication checkpoint (GO:0000076)4.49815193
27skeletal muscle tissue development (GO:0007519)4.47418111
28nuclear pore complex assembly (GO:0051292)4.46228854
29protein localization to chromosome, centromeric region (GO:0071459)4.45029399
30synaptic vesicle maturation (GO:0016188)4.42602383
31metaphase plate congression (GO:0051310)4.38503202
32sister chromatid segregation (GO:0000819)4.35664526
33mitotic chromosome condensation (GO:0007076)4.31559574
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.30795362
35DNA replication-dependent nucleosome assembly (GO:0006335)4.27009916
36DNA replication-dependent nucleosome organization (GO:0034723)4.27009916
37regulation of meiosis I (GO:0060631)4.23297217
38mitotic nuclear envelope disassembly (GO:0007077)4.22257705
39mesenchymal cell differentiation involved in kidney development (GO:0072161)4.21545598
40mesenchymal cell differentiation involved in renal system development (GO:2001012)4.21545598
41regulation of cardioblast differentiation (GO:0051890)4.19309125
42maternal placenta development (GO:0001893)4.17828102
43histone H4-K12 acetylation (GO:0043983)4.14110011
44forelimb morphogenesis (GO:0035136)4.09309232
45synaptic vesicle docking involved in exocytosis (GO:0016081)4.06399125
46regulation of gene silencing by RNA (GO:0060966)3.99161312
47regulation of posttranscriptional gene silencing (GO:0060147)3.99161312
48regulation of gene silencing by miRNA (GO:0060964)3.99161312
49regulation of spindle organization (GO:0090224)3.98880702
50embryonic skeletal system morphogenesis (GO:0048704)3.98738093
51positive regulation of chromosome segregation (GO:0051984)3.98709292
52regulation of telomere maintenance via telomerase (GO:0032210)3.96863370
53meiotic chromosome segregation (GO:0045132)3.96136910
54membrane disassembly (GO:0030397)3.94506289
55nuclear envelope disassembly (GO:0051081)3.94506289
56neurogenesis (GO:0022008)3.88856229
57positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.87918490
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.86930941
59attachment of spindle microtubules to kinetochore (GO:0008608)3.84928489
60thyroid gland development (GO:0030878)3.82464387
61piRNA metabolic process (GO:0034587)3.78807096
62positive regulation of digestive system process (GO:0060456)3.76101938
63kinetochore assembly (GO:0051382)3.74314190
64regulation of sister chromatid cohesion (GO:0007063)3.74162481
65DNA replication initiation (GO:0006270)3.73617310
66mesenchyme morphogenesis (GO:0072132)3.72816585
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.70573594
68establishment of chromosome localization (GO:0051303)3.70462564
69cell differentiation involved in metanephros development (GO:0072202)3.68951781
70histone H2A monoubiquitination (GO:0035518)3.63726912
71protein K6-linked ubiquitination (GO:0085020)3.63487518
72kinetochore organization (GO:0051383)3.61602754
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.61428827
74regulation of chromosome segregation (GO:0051983)3.61158202
75protein localization to chromosome (GO:0034502)3.59228934
76positive regulation of mitotic sister chromatid separation (GO:1901970)3.58638060
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58638060
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58638060
79negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.58327038
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58111103
81maturation of 5.8S rRNA (GO:0000460)3.57786667
82aorta morphogenesis (GO:0035909)3.57734522
83chromosome segregation (GO:0007059)3.57341157
84negative regulation of histone methylation (GO:0031061)3.57278315
85regulation of mitotic spindle organization (GO:0060236)3.56714301
86positive regulation of embryonic development (GO:0040019)3.53584235
87regulation of short-term neuronal synaptic plasticity (GO:0048172)3.52047847
88cochlea morphogenesis (GO:0090103)3.51379020
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.51118510
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.50938647
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50938647
92regulation of chromatin binding (GO:0035561)3.49796388
93spindle checkpoint (GO:0031577)3.49670036
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.48415936
95axon extension (GO:0048675)3.47312418
96regulation of histone H3-K27 methylation (GO:0061085)3.46184058
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45080915
98ribosome biogenesis (GO:0042254)3.44553786
99negative regulation of chromosome segregation (GO:0051985)3.44154020
100replication fork processing (GO:0031297)3.43771806
101embryonic forelimb morphogenesis (GO:0035115)3.42224397
102regulation of transforming growth factor beta2 production (GO:0032909)3.41512279
103pre-miRNA processing (GO:0031054)3.41023878
104heterochromatin organization (GO:0070828)3.40961199
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40763938
106regulation of synapse assembly (GO:0051963)3.39889561
107muscle cell migration (GO:0014812)3.38515287
108negative regulation of meiosis (GO:0045835)3.38429706
109pore complex assembly (GO:0046931)3.36224633
110positive regulation of gastrulation (GO:2000543)3.35617583
111chromatin remodeling at centromere (GO:0031055)3.34978704
112cochlea development (GO:0090102)3.33202389
113positive regulation of mesonephros development (GO:0061213)3.32871216
114positive regulation of CREB transcription factor activity (GO:0032793)3.32576972
115protein retention in ER lumen (GO:0006621)3.31317924
116histone H4-K5 acetylation (GO:0043981)3.30167317
117histone H4-K8 acetylation (GO:0043982)3.30167317
118mitotic spindle checkpoint (GO:0071174)3.29102757
119DNA damage response, signal transduction resulting in transcription (GO:0042772)3.26939595
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26348527
121formation of translation preinitiation complex (GO:0001731)3.26232785
122metanephric nephron tubule development (GO:0072234)3.25766058
123metanephric tubule development (GO:0072170)3.25766058
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25542385
125DNA replication-independent nucleosome organization (GO:0034724)3.24254593
126DNA replication-independent nucleosome assembly (GO:0006336)3.24254593
127regulation of vesicle fusion (GO:0031338)3.23851692
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23160423
129regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22724930
130spindle assembly checkpoint (GO:0071173)3.21679383
131negative regulation of mitotic sister chromatid separation (GO:2000816)3.20796299
132negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20796299
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20796299
134negative regulation of sister chromatid segregation (GO:0033046)3.20796299
135CENP-A containing nucleosome assembly (GO:0034080)3.20700945
136developmental induction (GO:0031128)3.20597157
137regulation of organ formation (GO:0003156)3.20569720
138folic acid-containing compound biosynthetic process (GO:0009396)3.19842555
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19664020
140regulation of double-strand break repair (GO:2000779)3.19228331
141neuromuscular process controlling balance (GO:0050885)3.18720948
142nucleobase biosynthetic process (GO:0046112)3.17914827
143mitotic spindle assembly checkpoint (GO:0007094)3.16906934
144hindlimb morphogenesis (GO:0035137)3.16523294
145nuclear envelope organization (GO:0006998)3.16231799
146ribosome assembly (GO:0042255)3.15822766
147gamma-aminobutyric acid signaling pathway (GO:0007214)3.14969468
148regulation of DNA methylation (GO:0044030)3.14653903
149trophoblast giant cell differentiation (GO:0060707)3.14556353
150chromatin assembly or disassembly (GO:0006333)3.13886548
151regulation of sister chromatid segregation (GO:0033045)3.13778693
152regulation of mitotic sister chromatid separation (GO:0010965)3.13778693
153regulation of mitotic sister chromatid segregation (GO:0033047)3.13778693
154Golgi transport vesicle coating (GO:0048200)3.12980534
155COPI coating of Golgi vesicle (GO:0048205)3.12980534
156intestinal epithelial cell development (GO:0060576)3.12353622
157purine nucleobase biosynthetic process (GO:0009113)3.11387522
158middle ear morphogenesis (GO:0042474)3.10682418
159synaptonemal complex assembly (GO:0007130)3.10126493
160regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.09509723
161response to histamine (GO:0034776)3.09144414
162striated muscle tissue development (GO:0014706)3.06992592
163histone exchange (GO:0043486)3.06919464
164glutamate secretion (GO:0014047)3.04984097
165regulation of heart morphogenesis (GO:2000826)3.04811040
166pharyngeal system development (GO:0060037)3.04475977
167cell proliferation involved in metanephros development (GO:0072203)3.04214885
168chromatin assembly (GO:0031497)3.04055794
169positive regulation of chondrocyte differentiation (GO:0032332)3.02325094
170skeletal system morphogenesis (GO:0048705)3.02088680
171regulation of centrosome cycle (GO:0046605)3.01831757
172cell-cell signaling involved in cell fate commitment (GO:0045168)3.01431955
173folic acid metabolic process (GO:0046655)3.00891811
174paraxial mesoderm development (GO:0048339)3.00700550
175regulation of helicase activity (GO:0051095)3.00212282
176neuron projection extension (GO:1990138)2.99998682
177regulation of hippo signaling (GO:0035330)2.99630085
178negative regulation of smooth muscle cell differentiation (GO:0051151)2.99314548
179rRNA modification (GO:0000154)2.99151986
180positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98619840
181morphogenesis of an epithelial fold (GO:0060571)2.98196647
182layer formation in cerebral cortex (GO:0021819)2.95610153
183DNA strand elongation involved in DNA replication (GO:0006271)2.95423305
184metanephric nephron epithelium development (GO:0072243)2.94962964
185somite development (GO:0061053)2.93765222
186embryonic digestive tract development (GO:0048566)2.92103329
187mesonephros development (GO:0001823)2.91228555
188Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89858435
189enteric nervous system development (GO:0048484)2.89495829
190embryonic organ morphogenesis (GO:0048562)2.86147973
191muscle tissue development (GO:0060537)2.85710452
192neuromuscular process (GO:0050905)2.83703793
193embryonic skeletal system development (GO:0048706)2.83415007
194negative regulation of embryonic development (GO:0045992)2.81564553
195metanephric epithelium development (GO:0072207)2.81276066
196locomotory exploration behavior (GO:0035641)2.78600453
197neuron projection extension involved in neuron projection guidance (GO:1902284)2.77423340
198metanephric mesenchyme development (GO:0072075)12.6871492
199kidney mesenchyme development (GO:0072074)11.0593127
200peripheral nervous system neuron development (GO:0048935)10.0418618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57075477
2EZH2_22144423_ChIP-Seq_EOC_Human6.05769400
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.96897780
4EZH2_27304074_Chip-Seq_ESCs_Mouse4.47137160
5JARID2_20075857_ChIP-Seq_MESCs_Mouse3.75407274
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.72818560
7RNF2_18974828_ChIP-Seq_MESCs_Mouse3.55867445
8EZH2_18974828_ChIP-Seq_MESCs_Mouse3.55867445
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.47026033
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43370902
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41271653
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.37878647
13JARID2_20064375_ChIP-Seq_MESCs_Mouse3.35033534
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34474073
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34474073
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34474073
17TP53_20018659_ChIP-ChIP_R1E_Mouse3.17191216
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.94499852
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.91807520
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.81922026
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.78548338
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.76473367
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74255753
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.69286460
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57624876
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57190145
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.56961049
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56110707
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.51443696
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.49738870
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45619438
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.44963042
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42137729
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41219931
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.40557077
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.39346251
37MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38204381
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35575839
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.33668794
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33221624
41AR_21909140_ChIP-Seq_LNCAP_Human2.33176491
42WT1_19549856_ChIP-ChIP_CCG9911_Human2.20929910
43ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10198710
44MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09895430
45MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08846491
46TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08188628
47TCF3_18692474_ChIP-Seq_MESCs_Mouse2.07216626
48NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05923686
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05890353
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05195967
51BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02609681
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00940796
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.97511707
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94464426
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.94069270
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.93842585
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93467638
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92761888
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87802204
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85317569
61KDM2B_26808549_Chip-Seq_K562_Human1.84635220
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.84474889
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84414052
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84248699
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.81686748
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.81510781
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.81244382
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.79771436
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.75999596
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75698309
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74312803
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73409231
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72825867
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63989469
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63456268
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62026624
77* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60209785
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60062285
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.59558645
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59078650
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58223041
82XRN2_22483619_ChIP-Seq_HELA_Human1.58043031
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.54760575
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54583994
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54012039
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53543597
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.52435377
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52200654
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50694591
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50053113
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.47860371
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47441177
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47084195
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.47061926
95DROSHA_22980978_ChIP-Seq_HELA_Human1.44101530
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.42300145
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40055386
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37595022
99* KDM5A_27292631_Chip-Seq_BREAST_Human1.37398367
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34634497
101GABP_19822575_ChIP-Seq_HepG2_Human1.32927536
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32233364
103VDR_23849224_ChIP-Seq_CD4+_Human1.31658970
104NANOG_18692474_ChIP-Seq_MESCs_Mouse1.30790767
105RACK7_27058665_Chip-Seq_MCF-7_Human1.29982902
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29491676
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.27474277
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.27312485
109RNF2_27304074_Chip-Seq_NSC_Mouse1.27133728
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26806831
111SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26462285
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23759036
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23720441
114POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23473072
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23140559
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22883717
117TTF2_22483619_ChIP-Seq_HELA_Human1.22551598
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22231230
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21576237
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21514679
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20489329
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20339060
123KAP1_27257070_Chip-Seq_ESCs_Mouse1.18973395
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18333400
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17154174
126LXR_22292898_ChIP-Seq_THP-1_Human1.16774398
127DCP1A_22483619_ChIP-Seq_HELA_Human1.16438679
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.15625545
129FOXP3_21729870_ChIP-Seq_TREG_Human1.15587133
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15484275
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14030260
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13965424
133KDM2B_26808549_Chip-Seq_DND41_Human1.13721503
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.13143676
135KDM2B_26808549_Chip-Seq_JURKAT_Human1.12922567
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11806327
137REST_21632747_ChIP-Seq_MESCs_Mouse1.11612814
138SA1_27219007_Chip-Seq_Bcells_Human1.11575314
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10731121
140ELK3_25401928_ChIP-Seq_HUVEC_Human1.10431202
141MYC_22102868_ChIP-Seq_BL_Human1.08446216
142RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07517011
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06671462
144OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06449355
145TCF7_22412390_ChIP-Seq_EML_Mouse1.05947571
146ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05849503
147* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05140607
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03775514
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02564691
150MYC_27129775_Chip-Seq_CORNEA_Mouse1.01630506
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01258871
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00596638
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98908631
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98158907
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97260313
156NANOG_16518401_ChIP-PET_MESCs_Mouse0.96921883
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96192881
158CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96120106
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.95943632
160POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94609424
161TFEB_21752829_ChIP-Seq_HELA_Human0.94481539
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94458112
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94024593
164CREB1_26743006_Chip-Seq_LNCaP_Human0.92109462
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91497893
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89775429
167EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89595002
168CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89489969
169MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88027075
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87828403
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.86961750
172CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86665354
173CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81438739
174MAF_26560356_Chip-Seq_TH2_Human0.80537273
175CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80238505
176CTCF_27219007_Chip-Seq_Bcells_Human0.79856329
177SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79285194
178CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78861695
179OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77475213
180CDX2_20551321_ChIP-Seq_CACO-2_Human0.77264141
181GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76775918
182AR_21572438_ChIP-Seq_LNCaP_Human0.74619169
183WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73608832
184TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72967956
185KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72898001
186TET1_21490601_ChIP-Seq_MESCs_Mouse0.71742407
187RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70447940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.48407248
2MP0003693_abnormal_embryo_hatching4.59242475
3MP0008057_abnormal_DNA_replication4.29731800
4MP0003111_abnormal_nucleus_morphology4.28073806
5MP0004957_abnormal_blastocyst_morpholog4.23434864
6MP0010094_abnormal_chromosome_stability4.08250114
7MP0001346_abnormal_lacrimal_gland3.74870987
8MP0003077_abnormal_cell_cycle3.63084984
9MP0008438_abnormal_cutaneous_collagen3.46678974
10MP0008877_abnormal_DNA_methylation3.24130215
11MP0000733_abnormal_muscle_development3.08098352
12MP0004859_abnormal_synaptic_plasticity3.07976037
13MP0002932_abnormal_joint_morphology3.06951235
14MP0008789_abnormal_olfactory_epithelium3.00604299
15MP0002653_abnormal_ependyma_morphology2.94622605
16MP0003718_maternal_effect2.93942812
17MP0001177_atelectasis2.88673693
18MP0008058_abnormal_DNA_repair2.60560304
19MP0000534_abnormal_ureter_morphology2.49000779
20MP0001730_embryonic_growth_arrest2.45620823
21MP0003123_paternal_imprinting2.43425349
22MP0000350_abnormal_cell_proliferation2.38013028
23MP0008932_abnormal_embryonic_tissue2.35194539
24MP0003115_abnormal_respiratory_system2.31386466
25MP0005380_embryogenesis_phenotype2.19802027
26MP0001672_abnormal_embryogenesis/_devel2.19802027
27MP0006292_abnormal_olfactory_placode2.17307027
28MP0001501_abnormal_sleep_pattern2.16456517
29MP0003890_abnormal_embryonic-extraembry2.15820821
30MP0005508_abnormal_skeleton_morphology2.10113963
31MP0008007_abnormal_cellular_replicative2.09729101
32MP0002084_abnormal_developmental_patter2.07469013
33MP0002085_abnormal_embryonic_tissue2.06960752
34MP0003786_premature_aging2.05637634
35MP0005248_abnormal_Harderian_gland2.03713035
36MP0003385_abnormal_body_wall1.96736128
37MP0001697_abnormal_embryo_size1.96622610
38MP0001270_distended_abdomen1.96049079
39MP0010352_gastrointestinal_tract_polyps1.94263533
40MP0004264_abnormal_extraembryonic_tissu1.91125418
41MP0005171_absent_coat_pigmentation1.86638155
42MP0003984_embryonic_growth_retardation1.84775011
43MP0010307_abnormal_tumor_latency1.83884273
44MP0001299_abnormal_eye_distance/1.81830842
45MP0002088_abnormal_embryonic_growth/wei1.81803413
46MP0002086_abnormal_extraembryonic_tissu1.81633547
47MP0000613_abnormal_salivary_gland1.81120386
48MP0009780_abnormal_chondrocyte_physiolo1.79321516
49MP0003942_abnormal_urinary_system1.79203116
50MP0002210_abnormal_sex_determination1.76567219
51MP0003635_abnormal_synaptic_transmissio1.70138412
52MP0002184_abnormal_innervation1.67801351
53MP0004270_analgesia1.64716469
54MP0001145_abnormal_male_reproductive1.59476392
55MP0001929_abnormal_gametogenesis1.58714265
56MP0003121_genomic_imprinting1.57506356
57MP0008569_lethality_at_weaning1.55186107
58MP0002080_prenatal_lethality1.54991719
59MP0001485_abnormal_pinna_reflex1.54968268
60MP0003119_abnormal_digestive_system1.54240999
61MP0000653_abnormal_sex_gland1.49677597
62MP0010030_abnormal_orbit_morphology1.48948715
63MP0004197_abnormal_fetal_growth/weight/1.48907114
64MP0002116_abnormal_craniofacial_bone1.47565842
65MP0002233_abnormal_nose_morphology1.46241789
66MP0005076_abnormal_cell_differentiation1.43976847
67MP0005451_abnormal_body_composition1.40005853
68MP0001879_abnormal_lymphatic_vessel1.35705106
69MP0009250_abnormal_appendicular_skeleto1.33179217
70MP0002108_abnormal_muscle_morphology1.32100203
71MP0000026_abnormal_inner_ear1.31734825
72MP0002896_abnormal_bone_mineralization1.31555475
73MP0000759_abnormal_skeletal_muscle1.31122883
74MP0000955_abnormal_spinal_cord1.31067621
75MP0005645_abnormal_hypothalamus_physiol1.30961902
76MP0003937_abnormal_limbs/digits/tail_de1.29692403
77MP0002063_abnormal_learning/memory/cond1.29060603
78MP0002109_abnormal_limb_morphology1.28998338
79MP0001293_anophthalmia1.27738584
80MP0008995_early_reproductive_senescence1.27670451
81MP0004742_abnormal_vestibular_system1.26811241
82MP0001188_hyperpigmentation1.26349478
83MP0005409_darkened_coat_color1.25801837
84MP0002277_abnormal_respiratory_mucosa1.23333486
85MP0005275_abnormal_skin_tensile1.23164105
86MP0001119_abnormal_female_reproductive1.21710988
87MP0000762_abnormal_tongue_morphology1.21381575
88MP0001963_abnormal_hearing_physiology1.21268234
89MP0005395_other_phenotype1.19843855
90MP0000313_abnormal_cell_death1.18263609
91MP0000049_abnormal_middle_ear1.18259002
92MP0002064_seizures1.17641482
93MP0003699_abnormal_female_reproductive1.16691941
94MP0004133_heterotaxia1.16173292
95MP0003705_abnormal_hypodermis_morpholog1.15205773
96MP0004811_abnormal_neuron_physiology1.14811550
97MP0000778_abnormal_nervous_system1.13650866
98MP0002113_abnormal_skeleton_development1.13266105
99MP0002019_abnormal_tumor_incidence1.11010311
100MP0002249_abnormal_larynx_morphology1.09319730
101MP0002102_abnormal_ear_morphology1.09022452
102MP0002752_abnormal_somatic_nervous1.08629298
103MP0003315_abnormal_perineum_morphology1.07769590
104MP0001502_abnormal_circadian_rhythm1.05754121
105MP0009046_muscle_twitch1.05581716
106MP0004185_abnormal_adipocyte_glucose1.04840613
107MP0000490_abnormal_crypts_of1.03957402
108MP0003806_abnormal_nucleotide_metabolis1.02709904
109MP0002882_abnormal_neuron_morphology1.02689558
110MP0001849_ear_inflammation1.01167923
111MP0001943_abnormal_respiration0.99143428
112MP0005423_abnormal_somatic_nervous0.98873394
113MP0002115_abnormal_skeleton_extremities0.98814603
114MP0009745_abnormal_behavioral_response0.97555402
115MP0003567_abnormal_fetal_cardiomyocyte0.96711870
116MP0003755_abnormal_palate_morphology0.96639064
117MP0002090_abnormal_vision0.96457741
118MP0000639_abnormal_adrenal_gland0.96368709
119MP0003136_yellow_coat_color0.95037670
120MP0002067_abnormal_sensory_capabilities0.94560754
121MP0005390_skeleton_phenotype0.94028151
122MP0002161_abnormal_fertility/fecundity0.93308032
123MP0003698_abnormal_male_reproductive0.92786667
124MP0003634_abnormal_glial_cell0.91878102
125MP0000432_abnormal_head_morphology0.91853421
126MP0003646_muscle_fatigue0.91723925
127MP0003878_abnormal_ear_physiology0.91270728
128MP0005377_hearing/vestibular/ear_phenot0.91270728
129MP0002572_abnormal_emotion/affect_behav0.90612713
130MP0002396_abnormal_hematopoietic_system0.90515873
131MP0003787_abnormal_imprinting0.90491146
132MP0002111_abnormal_tail_morphology0.89528214
133MP0003879_abnormal_hair_cell0.86904622
134MP0005621_abnormal_cell_physiology0.85056035
135MP0003861_abnormal_nervous_system0.85041803
136MP0003941_abnormal_skin_development0.83415594
137MP0002877_abnormal_melanocyte_morpholog0.83002115
138MP0005058_abnormal_lysosome_morphology0.82546059
139MP0003633_abnormal_nervous_system0.80965118
140MP0003880_abnormal_central_pattern0.80918413
141MP0001486_abnormal_startle_reflex0.80714599
142MP0002735_abnormal_chemical_nociception0.80383835
143MP0005266_abnormal_metabolism0.80164271
144MP0002133_abnormal_respiratory_system0.80153948
145MP0005388_respiratory_system_phenotype0.80153948
146MP0005384_cellular_phenotype0.79113679
147MP0003950_abnormal_plasma_membrane0.79085293
148MP0003935_abnormal_craniofacial_develop0.78042843
149MP0002066_abnormal_motor_capabilities/c0.78028103
150MP0005394_taste/olfaction_phenotype0.77231887
151MP0005499_abnormal_olfactory_system0.77231887
152MP0001440_abnormal_grooming_behavior0.77042515
153MP0003936_abnormal_reproductive_system0.76491642
154MP0002092_abnormal_eye_morphology0.76068837
155MP0005023_abnormal_wound_healing0.76053383
156MP0003566_abnormal_cell_adhesion0.76025762
157MP0002272_abnormal_nervous_system0.75952943
158MP0009703_decreased_birth_body0.75360482
159MP0003283_abnormal_digestive_organ0.74938195
160MP0008874_decreased_physiological_sensi0.74033730
161MP0003938_abnormal_ear_development0.71681321
162MP0002114_abnormal_axial_skeleton0.71126305
163MP0002332_abnormal_exercise_endurance0.70897231
164MP0001915_intracranial_hemorrhage0.70458115
165MP0001286_abnormal_eye_development0.70275506
166MP0002081_perinatal_lethality0.69975249
167MP0000428_abnormal_craniofacial_morphol0.69021258
168MP0000462_abnormal_digestive_system0.68943555
169MP0002734_abnormal_mechanical_nocicepti0.67548642
170MP0003221_abnormal_cardiomyocyte_apopto0.66878625
171MP0003453_abnormal_keratinocyte_physiol0.66590254
172MP0005197_abnormal_uvea_morphology0.66437655
173MP0000372_irregular_coat_pigmentation0.66215270
174MP0002269_muscular_atrophy0.66168519
175MP0005389_reproductive_system_phenotype0.65916477
176MP0002152_abnormal_brain_morphology0.65743874
177MP0002160_abnormal_reproductive_system0.65672531
178MP0002751_abnormal_autonomic_nervous0.63742452
179MP0002127_abnormal_cardiovascular_syste0.63540927
180MP0009672_abnormal_birth_weight0.62455863
181MP0006072_abnormal_retinal_apoptosis0.61888964
182MP0004233_abnormal_muscle_weight0.61310798
183MP0000358_abnormal_cell_content/0.60228975

Predicted human phenotypes

RankGene SetZ-score
1Calcaneovalgus deformity (HP:0001848)8.36557491
2Deformed tarsal bones (HP:0008119)7.31644239
3Lip pit (HP:0100267)7.21158236
4Premature rupture of membranes (HP:0001788)5.66368646
5Atrioventricular block (HP:0001678)5.33168435
6Abnormality of the calcaneus (HP:0008364)5.14172961
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.75569150
8Chromsome breakage (HP:0040012)4.71253628
9Abnormality of the labia minora (HP:0012880)4.44890996
10Ependymoma (HP:0002888)4.35871823
11Breast hypoplasia (HP:0003187)4.31768599
12Birth length less than 3rd percentile (HP:0003561)4.23264296
13Rib fusion (HP:0000902)4.18022278
14Mitral valve prolapse (HP:0001634)4.12515818
15Spondylolisthesis (HP:0003302)4.00999302
16Aortic dissection (HP:0002647)4.00522759
17Shawl scrotum (HP:0000049)3.78729314
18Facial hemangioma (HP:0000329)3.78241157
19Prolonged QT interval (HP:0001657)3.67559293
20Patellar aplasia (HP:0006443)3.62019863
21Heart block (HP:0012722)3.60891358
22Absent radius (HP:0003974)3.60559864
23Spinal cord lesions (HP:0100561)3.59525255
24Syringomyelia (HP:0003396)3.59525255
25Rhabdomyosarcoma (HP:0002859)3.57823266
26Arterial tortuosity (HP:0005116)3.53083991
27Abnormal atrioventricular conduction (HP:0005150)3.38739588
28Absent forearm bone (HP:0003953)3.38637564
29Aplasia involving forearm bones (HP:0009822)3.38637564
30Soft skin (HP:0000977)3.37887337
31Fragile skin (HP:0001030)3.35908370
32Aplasia/Hypoplasia of the patella (HP:0006498)3.35300130
33Abnormality of the astrocytes (HP:0100707)3.34365696
34Astrocytoma (HP:0009592)3.34365696
35Nuclear cataract (HP:0100018)3.34124441
36Impulsivity (HP:0100710)3.32133930
37Infantile muscular hypotonia (HP:0008947)3.30104678
38Genu recurvatum (HP:0002816)3.28972283
39Aplasia/hypoplasia of the humerus (HP:0006507)3.27834307
40Abnormality of the ileum (HP:0001549)3.27123074
41Meckel diverticulum (HP:0002245)3.27114495
42Supernumerary spleens (HP:0009799)3.19127637
43Short middle phalanx of the 5th finger (HP:0004220)3.16642075
44Protrusio acetabuli (HP:0003179)3.12344485
45Aplasia/Hypoplasia of the uvula (HP:0010293)3.11378904
46Short humerus (HP:0005792)3.03873536
47Neoplasm of the oral cavity (HP:0100649)3.02876370
48Abnormality of chromosome stability (HP:0003220)3.01403590
49Medulloblastoma (HP:0002885)2.99231590
50Carpal bone hypoplasia (HP:0001498)2.97373166
51Atonic seizures (HP:0010819)2.96739134
52Male infertility (HP:0003251)2.96421490
53Vertebral compression fractures (HP:0002953)2.96208942
54Neoplasm of striated muscle (HP:0009728)2.95155185
55Action tremor (HP:0002345)2.94161967
56Abnormality of the preputium (HP:0100587)2.93612151
57Bladder diverticulum (HP:0000015)2.91356197
58Vascular tortuosity (HP:0004948)2.90341732
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89078894
60Periauricular skin pits (HP:0100277)2.86761317
61Preauricular pit (HP:0004467)2.86761317
62Midline defect of the nose (HP:0004122)2.86117577
63Hyperextensible skin (HP:0000974)2.84683893
64Premature ovarian failure (HP:0008209)2.77315408
65Peritonitis (HP:0002586)2.76868912
66Hypochromic microcytic anemia (HP:0004840)2.73601661
67Glioma (HP:0009733)2.69663862
68Small intestinal stenosis (HP:0012848)2.68953892
69Duodenal stenosis (HP:0100867)2.68953892
70Nephroblastoma (Wilms tumor) (HP:0002667)2.63488584
71Rectovaginal fistula (HP:0000143)2.59736097
72Rectal fistula (HP:0100590)2.59736097
73Selective tooth agenesis (HP:0001592)2.56077221
74Zonular cataract (HP:0010920)2.55017829
75Ectopic kidney (HP:0000086)2.47122849
76Blue sclerae (HP:0000592)2.43671894
77Atrophic scars (HP:0001075)2.43182623
78Intestinal fistula (HP:0100819)2.41970699
79Bilateral microphthalmos (HP:0007633)2.40752754
80Embryonal renal neoplasm (HP:0011794)2.40338805
81Multiple enchondromatosis (HP:0005701)2.37026619
82Degeneration of anterior horn cells (HP:0002398)2.36546855
83Abnormality of the anterior horn cell (HP:0006802)2.36546855
84Myelodysplasia (HP:0002863)2.35747527
85Annular pancreas (HP:0001734)2.35357585
86Abnormality of macular pigmentation (HP:0008002)2.35058585
87Abnormality of the lower motor neuron (HP:0002366)2.34760486
88Abnormality of dentin (HP:0010299)2.34513497
89Ectopia lentis (HP:0001083)2.34263056
90Truncal ataxia (HP:0002078)2.33915831
91Volvulus (HP:0002580)2.33274198
92Secondary amenorrhea (HP:0000869)2.32796772
93Hypoplastic left heart (HP:0004383)2.30699574
94Hypophosphatemic rickets (HP:0004912)2.29738440
95Capillary hemangiomas (HP:0005306)2.28912158
96Tongue fasciculations (HP:0001308)2.28239999
97Absent thumb (HP:0009777)2.27566013
98Agnosia (HP:0010524)2.27536433
99Patchy hypopigmentation of hair (HP:0011365)2.25262100
100Cafe-au-lait spot (HP:0000957)2.24499974
101Abnormal lung lobation (HP:0002101)2.23795232
102Spinal cord compression (HP:0002176)2.23352570
103White forelock (HP:0002211)2.23211711
104Skin pits (HP:0100276)2.22560681
105Obstructive sleep apnea (HP:0002870)2.22284822
106Abnormality of the duodenum (HP:0002246)2.22247615
107Horseshoe kidney (HP:0000085)2.20854363
108Abnormality of the salivary glands (HP:0010286)2.17091169
109Myokymia (HP:0002411)2.15635401
110Cerebral hypomyelination (HP:0006808)2.15287952
111Sloping forehead (HP:0000340)2.14729779
112Abdominal situs inversus (HP:0003363)2.14380700
113Abnormality of abdominal situs (HP:0011620)2.14380700
114Papillary thyroid carcinoma (HP:0002895)2.13468945
115Hypercortisolism (HP:0001578)2.12355558
116Overlapping toe (HP:0001845)2.12283579
117Abnormality of chromosome segregation (HP:0002916)2.09304725
118Aplasia/Hypoplasia of the sternum (HP:0006714)2.08813271
119Vaginal fistula (HP:0004320)2.08456510
120Deep palmar crease (HP:0006191)2.08265587
121Oral leukoplakia (HP:0002745)2.08185239
122Breast aplasia (HP:0100783)2.07920452
123Abnormal EKG (HP:0003115)2.07902801
124Facial shape deformation (HP:0011334)2.07872293
125Potter facies (HP:0002009)2.07872293
126Bell-shaped thorax (HP:0001591)2.07312367
127Broad distal phalanx of finger (HP:0009836)2.06463772
128Adrenal hypoplasia (HP:0000835)2.06414007
129Muscle fibrillation (HP:0010546)2.06138170
130Fused cervical vertebrae (HP:0002949)2.05392099
131Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05317603
132Rough bone trabeculation (HP:0100670)2.03939826
133Short thumb (HP:0009778)2.02238438
134Supranuclear gaze palsy (HP:0000605)1.98439019
135Abnormality of lateral ventricle (HP:0030047)1.96647613
136Oligodactyly (HP:0012165)1.96431825
137Squamous cell carcinoma (HP:0002860)1.95029775
138Long palpebral fissure (HP:0000637)1.94536449
139Bone marrow hypocellularity (HP:0005528)1.94421827
140Delayed puberty (HP:0000823)1.94339489
141Focal motor seizures (HP:0011153)1.93864264
142Aplasia/Hypoplasia of the breasts (HP:0010311)1.92931423
143Basal cell carcinoma (HP:0002671)1.91331031
144Tracheoesophageal fistula (HP:0002575)1.91143027
145Premature graying of hair (HP:0002216)1.90001744
146Abnormality of the carotid arteries (HP:0005344)1.88978343
147Spinal muscular atrophy (HP:0007269)1.88003460
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.86090134
149Sparse lateral eyebrow (HP:0005338)1.85482290
150Hemivertebrae (HP:0002937)1.85327974
151Sandal gap (HP:0001852)1.84500244
152Gastrointestinal carcinoma (HP:0002672)1.83789320
153Malignant gastrointestinal tract tumors (HP:0006749)1.83789320
154Abnormality of the peritoneum (HP:0002585)1.82971823
155Prominent nose (HP:0000448)1.80774121
156Atresia of the external auditory canal (HP:0000413)1.80451443
157Broad alveolar ridges (HP:0000187)1.79951451
158Biliary tract neoplasm (HP:0100574)1.78986355
159Missing ribs (HP:0000921)1.78571998
160Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77120365
161Short 5th finger (HP:0009237)1.76603259
162Biconcave vertebral bodies (HP:0004586)1.73833072
163Generalized tonic-clonic seizures (HP:0002069)1.70259513
164Hammertoe (HP:0001765)1.69551902
165Cubitus valgus (HP:0002967)1.69486385
166Preauricular skin tag (HP:0000384)1.69188190
167Inguinal hernia (HP:0000023)1.68209038
168Cupped ribs (HP:0000887)1.66656524
169Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.66342593
170Thickened helices (HP:0000391)1.64625593
171Mild short stature (HP:0003502)1.63690347
172Hypoplastic heart (HP:0001961)1.63519345
173Focal seizures (HP:0007359)1.63396025
174Heterochromia iridis (HP:0001100)1.63355312
175Papilledema (HP:0001085)1.63076734
176Rocker bottom foot (HP:0001838)1.62318500
177Metaphyseal cupping (HP:0003021)1.61996804
178Growth hormone excess (HP:0000845)1.58880697
179Absent eyebrow (HP:0002223)1.57912631
180Emphysema (HP:0002097)1.57649837
181Multiple lipomas (HP:0001012)1.57049392
182Skin tags (HP:0010609)1.56729897
183Hyperparathyroidism (HP:0000843)1.56729342
184Dysmetric saccades (HP:0000641)1.56617369
185Megalencephaly (HP:0001355)1.56012977
186Bowel diverticulosis (HP:0005222)1.55926875
187Neuronal loss in central nervous system (HP:0002529)1.55438537
188Orthostatic hypotension (HP:0001278)1.52640119
189Osteoarthritis (HP:0002758)1.50678780
190Asymmetry of the thorax (HP:0001555)1.50036289
191Hallux valgus (HP:0001822)1.49459559
192Supraventricular tachycardia (HP:0004755)1.48850132
193Elbow flexion contracture (HP:0002987)1.46875911
194Primary atrial arrhythmia (HP:0001692)1.46837085
195Spinal canal stenosis (HP:0003416)1.46502091
196Follicular hyperkeratosis (HP:0007502)1.45969415
197Atrial fibrillation (HP:0005110)1.45841897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.51837156
2NTRK14.01570052
3ERN13.85058546
4CDC73.69038116
5WEE13.59579877
6TTK3.59561788
7EPHA23.44926945
8ERBB33.26766280
9BUB13.26651551
10PRPF4B3.09126380
11LATS23.08547502
12TRPM72.83552766
13NEK22.78668763
14TRIB32.75400075
15TAOK32.53750525
16WNK12.53259436
17STK38L2.43180607
18PIK3CG2.42735443
19PLK12.38316347
20LATS12.29052407
21PLK42.27010999
22NEK12.13115393
23AKT32.07515385
24NEK62.04154632
25MAP3K62.02436561
26CHEK22.00152620
27EPHA41.97276371
28CDK71.96217573
29RPS6KB21.93465916
30EEF2K1.77685408
31MAPK71.77657601
32TYRO31.77227903
33PRKD31.72379672
34CDK31.72188501
35SRPK11.72123639
36ACVR1B1.67042697
37MARK21.60934991
38MAP3K91.54347559
39DYRK1A1.53154320
40AURKB1.45732610
41NTRK31.45212588
42BRSK21.41517232
43SIK21.40377233
44CHEK11.37054004
45RIPK11.36451364
46STK101.34882144
47AURKA1.31923017
48MAPKAPK31.30887538
49STK31.30100961
50BRAF1.28308715
51ERBB41.27822378
52KSR21.23569054
53CDK41.22302547
54DAPK21.20877046
55MOS1.18922599
56PLK31.18673549
57FLT31.14230688
58MELK1.12401273
59NTRK21.11069288
60CDK11A1.10128688
61CDK151.09796897
62EIF2AK11.09733869
63ATR1.07946801
64CDK51.07590428
65PNCK1.07445259
66CSNK1A1L1.05818218
67RAF11.04048488
68DYRK31.04037023
69ICK1.03929695
70CAMK1G1.03830510
71PRKCH1.03749321
72MAP3K81.02471122
73CDK181.01486471
74CDK21.01131200
75UHMK10.97932153
76ATM0.95915500
77DDR20.95830640
78CAMKK10.94927817
79MARK10.94542063
80MKNK20.94137966
81PRKCI0.91927140
82CDK140.91763143
83BRSK10.89901838
84PKN20.87757912
85MAPK120.87470576
86CAMK1D0.86052357
87MTOR0.81702932
88DYRK20.81265814
89TSSK60.80261142
90ALK0.76616428
91TAOK10.76349717
92MAP2K60.74443114
93MATK0.74394936
94MKNK10.73884621
95CDK10.72519424
96TESK20.71784086
97STK380.69608598
98MINK10.66985223
99SIK30.65929583
100PAK10.65523084
101PAK60.64452041
102PIM10.63887520
103CDK80.61947806
104BRD40.61654268
105PAK40.60737049
106CSNK1E0.59951212
107MARK30.59574757
108CSNK1G20.59338858
109PAK20.57511471
110RPS6KL10.54988229
111RPS6KC10.54988229
112STK40.54458179
113KSR10.53300574
114PDK30.52114609
115PDK40.52114609
116FGR0.50213722
117PASK0.49138767
118CAMK10.48978712
119GRK50.47561983
120RET0.46152126
121PRKAA10.44743133
122CDK60.44313644
123PINK10.43970325
124MAPK80.42325656
125MAPK100.42312514
126ARAF0.40526665
127PRKD20.40374989
128VRK10.40261808
129DAPK10.39912313
130DYRK1B0.39725853
131MAPK140.39258256
132MET0.39069925
133CSNK2A20.38474826
134RPS6KA60.38368929
135MAP3K70.37750417
136CSNK1D0.37466726
137GSK3B0.37438502
138NEK90.36927141
139MAP3K40.36882099
140CDK90.36836612
141EIF2AK30.36249189
142RIPK40.32809607
143CSNK1G30.32624785
144CSNK2A10.32497356
145TYK20.32328149
146MAPK10.32134517
147SMG10.32088590
148BMX0.31003489
149MAP3K130.29719825
150PLK20.29647458
151PDGFRA0.28762821
152PDK20.28676728
153SCYL20.28489778
154CAMK40.28407501
155MUSK0.28388165
156PRKCG0.27936529
157LRRK20.27712721
158MAPK90.27036413
159ABL20.26825716
160GRK60.26733863
161CSNK1G10.26440919
162MAP2K20.26260597
163AKT20.26024185
164PDPK10.25112123
165HCK0.24805728
166PRKDC0.24553746
167MAPK110.24420304
168PDK10.24157326
169RPS6KA30.23900536
170TAF10.22250483

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.52792874
2Mismatch repair_Homo sapiens_hsa034303.84662369
3DNA replication_Homo sapiens_hsa030303.67184273
4RNA transport_Homo sapiens_hsa030133.62507518
5Cell cycle_Homo sapiens_hsa041103.51283554
6Nicotine addiction_Homo sapiens_hsa050333.23872811
7RNA polymerase_Homo sapiens_hsa030202.95950435
8Homologous recombination_Homo sapiens_hsa034402.93529022
9Basal transcription factors_Homo sapiens_hsa030222.79449204
10Fanconi anemia pathway_Homo sapiens_hsa034602.77742479
11Vitamin B6 metabolism_Homo sapiens_hsa007502.77426878
12Base excision repair_Homo sapiens_hsa034102.71035812
13Spliceosome_Homo sapiens_hsa030402.62855416
14Nucleotide excision repair_Homo sapiens_hsa034202.54420891
15RNA degradation_Homo sapiens_hsa030182.38583048
16mRNA surveillance pathway_Homo sapiens_hsa030152.35139341
17Morphine addiction_Homo sapiens_hsa050322.25228822
18One carbon pool by folate_Homo sapiens_hsa006702.22358041
19p53 signaling pathway_Homo sapiens_hsa041152.07819281
20Long-term potentiation_Homo sapiens_hsa047202.06472330
21Melanogenesis_Homo sapiens_hsa049162.06191540
22Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01824424
23Synaptic vesicle cycle_Homo sapiens_hsa047211.91874093
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.91781841
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89826896
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85430820
27GABAergic synapse_Homo sapiens_hsa047271.82479109
28Glioma_Homo sapiens_hsa052141.77584571
29Oocyte meiosis_Homo sapiens_hsa041141.74518402
30Estrogen signaling pathway_Homo sapiens_hsa049151.67256441
31Amphetamine addiction_Homo sapiens_hsa050311.66711919
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65908083
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63518560
34Non-homologous end-joining_Homo sapiens_hsa034501.63466479
35Pyrimidine metabolism_Homo sapiens_hsa002401.58903354
36Proteasome_Homo sapiens_hsa030501.58089103
37Circadian entrainment_Homo sapiens_hsa047131.55670960
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54178593
39N-Glycan biosynthesis_Homo sapiens_hsa005101.51117486
40ErbB signaling pathway_Homo sapiens_hsa040121.50039162
41Oxytocin signaling pathway_Homo sapiens_hsa049211.42284581
42Cholinergic synapse_Homo sapiens_hsa047251.38713677
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34726463
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.34351717
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32344472
46Dopaminergic synapse_Homo sapiens_hsa047281.31943610
47Renin secretion_Homo sapiens_hsa049241.31070014
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.30802326
49Cocaine addiction_Homo sapiens_hsa050301.30708143
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27734419
51Calcium signaling pathway_Homo sapiens_hsa040201.26161207
52Hippo signaling pathway_Homo sapiens_hsa043901.22768172
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20582649
54Biosynthesis of amino acids_Homo sapiens_hsa012301.18784015
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18189332
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15629973
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12980987
58MicroRNAs in cancer_Homo sapiens_hsa052061.12017686
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10086221
60Salivary secretion_Homo sapiens_hsa049701.09665252
61GnRH signaling pathway_Homo sapiens_hsa049121.09609958
62TGF-beta signaling pathway_Homo sapiens_hsa043501.09265843
63mTOR signaling pathway_Homo sapiens_hsa041501.08550339
64Thyroid cancer_Homo sapiens_hsa052161.08487764
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08170563
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07304853
67Proteoglycans in cancer_Homo sapiens_hsa052051.06571803
68Thyroid hormone synthesis_Homo sapiens_hsa049181.04835285
69Pentose phosphate pathway_Homo sapiens_hsa000301.04490114
70Insulin secretion_Homo sapiens_hsa049111.02567660
71Glutamatergic synapse_Homo sapiens_hsa047241.01141000
72Linoleic acid metabolism_Homo sapiens_hsa005911.00830292
73Ribosome_Homo sapiens_hsa030101.00550585
74Axon guidance_Homo sapiens_hsa043601.00546856
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99084059
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98064486
77Gastric acid secretion_Homo sapiens_hsa049710.97002779
78Serotonergic synapse_Homo sapiens_hsa047260.95914229
79Folate biosynthesis_Homo sapiens_hsa007900.95312283
80Other glycan degradation_Homo sapiens_hsa005110.94864755
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93149969
82Adherens junction_Homo sapiens_hsa045200.90685204
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.89890225
84Type II diabetes mellitus_Homo sapiens_hsa049300.89306881
85Sulfur metabolism_Homo sapiens_hsa009200.89271564
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.89149006
87Epstein-Barr virus infection_Homo sapiens_hsa051690.89081161
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88557952
89Insulin signaling pathway_Homo sapiens_hsa049100.87972012
90cAMP signaling pathway_Homo sapiens_hsa040240.86401750
91Hedgehog signaling pathway_Homo sapiens_hsa043400.84796539
92Notch signaling pathway_Homo sapiens_hsa043300.83601927
93Fructose and mannose metabolism_Homo sapiens_hsa000510.82239493
94Selenocompound metabolism_Homo sapiens_hsa004500.82231373
95Purine metabolism_Homo sapiens_hsa002300.82221380
96Vibrio cholerae infection_Homo sapiens_hsa051100.81687791
97Circadian rhythm_Homo sapiens_hsa047100.81082097
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80593954
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79276891
100Viral carcinogenesis_Homo sapiens_hsa052030.76108652
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76036958
102Colorectal cancer_Homo sapiens_hsa052100.75031061
103Basal cell carcinoma_Homo sapiens_hsa052170.74737204
104Hepatitis B_Homo sapiens_hsa051610.73392355
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71288960
106Protein export_Homo sapiens_hsa030600.71083794
107Tight junction_Homo sapiens_hsa045300.71040856
108Prion diseases_Homo sapiens_hsa050200.69411671
109Bladder cancer_Homo sapiens_hsa052190.66691325
110Herpes simplex infection_Homo sapiens_hsa051680.66399082
111MAPK signaling pathway_Homo sapiens_hsa040100.63868541
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63187865
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62782165
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.61839360
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.61781146
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.61235821
117Arachidonic acid metabolism_Homo sapiens_hsa005900.60842679
118Small cell lung cancer_Homo sapiens_hsa052220.59887307
119Amoebiasis_Homo sapiens_hsa051460.58474032
120Endocytosis_Homo sapiens_hsa041440.58333978
121HTLV-I infection_Homo sapiens_hsa051660.56869398
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.55511101
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54814151
124Regulation of autophagy_Homo sapiens_hsa041400.53491367
125Rap1 signaling pathway_Homo sapiens_hsa040150.51713563
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49396479
127Lysine degradation_Homo sapiens_hsa003100.49073247
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48861631
129Glucagon signaling pathway_Homo sapiens_hsa049220.48565566
130Dorso-ventral axis formation_Homo sapiens_hsa043200.47157844
131Wnt signaling pathway_Homo sapiens_hsa043100.46514246
132Ovarian steroidogenesis_Homo sapiens_hsa049130.46368125
133Arginine and proline metabolism_Homo sapiens_hsa003300.45542891
134Pancreatic cancer_Homo sapiens_hsa052120.44907162
135Ras signaling pathway_Homo sapiens_hsa040140.44765292
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43743097
137Choline metabolism in cancer_Homo sapiens_hsa052310.43341616
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42965407
139Galactose metabolism_Homo sapiens_hsa000520.42772766
140Endometrial cancer_Homo sapiens_hsa052130.42512447
141Ether lipid metabolism_Homo sapiens_hsa005650.39811286
142Pathways in cancer_Homo sapiens_hsa052000.39619039
143Prostate cancer_Homo sapiens_hsa052150.36385771
144FoxO signaling pathway_Homo sapiens_hsa040680.32505608
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.32225907
146Glutathione metabolism_Homo sapiens_hsa004800.31967402
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31438465
148Carbon metabolism_Homo sapiens_hsa012000.29694140
149AMPK signaling pathway_Homo sapiens_hsa041520.29277928
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29049611
151Renal cell carcinoma_Homo sapiens_hsa052110.27438471
152Fatty acid biosynthesis_Homo sapiens_hsa000610.26899022
153Sulfur relay system_Homo sapiens_hsa041220.24369820
154VEGF signaling pathway_Homo sapiens_hsa043700.23720463
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.22610610
156Inositol phosphate metabolism_Homo sapiens_hsa005620.22300433
157Non-small cell lung cancer_Homo sapiens_hsa052230.19837788
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19449886
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17106371
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15858644
161Melanoma_Homo sapiens_hsa052180.15379656
162Apoptosis_Homo sapiens_hsa042100.14185791
163Chronic myeloid leukemia_Homo sapiens_hsa052200.12649774
164Systemic lupus erythematosus_Homo sapiens_hsa053220.09840211
165Acute myeloid leukemia_Homo sapiens_hsa052210.09459669
166Prolactin signaling pathway_Homo sapiens_hsa049170.09038214

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