PNMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.65420719
2sperm motility (GO:0030317)8.62323430
3epithelial cilium movement (GO:0003351)8.54255938
4cilium movement (GO:0003341)8.52371416
5acrosome assembly (GO:0001675)8.50295186
6acrosome reaction (GO:0007340)8.17640480
7motile cilium assembly (GO:0044458)7.59310157
8sperm-egg recognition (GO:0035036)7.35990383
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.07190501
10multicellular organism reproduction (GO:0032504)7.01861311
11plasma membrane fusion (GO:0045026)6.91569012
12binding of sperm to zona pellucida (GO:0007339)6.86932631
13piRNA metabolic process (GO:0034587)6.73047684
14male meiosis (GO:0007140)6.61959716
15regulation of cilium movement (GO:0003352)6.60792767
16spermatid development (GO:0007286)6.60306591
17cell wall macromolecule catabolic process (GO:0016998)6.54934508
18cell wall macromolecule metabolic process (GO:0044036)6.54934508
19cell-cell recognition (GO:0009988)6.53810365
20synaptonemal complex organization (GO:0070193)5.74725613
21reproduction (GO:0000003)5.70503432
22protein localization to cilium (GO:0061512)5.67030504
23pyrimidine nucleobase catabolic process (GO:0006208)5.45059500
24synaptonemal complex assembly (GO:0007130)5.27048826
25ventricular system development (GO:0021591)5.15907106
26postsynaptic membrane organization (GO:0001941)5.07134257
27calcium ion-dependent exocytosis (GO:0017156)4.86274694
28establishment of mitochondrion localization (GO:0051654)4.82731886
29regulation of synaptic vesicle exocytosis (GO:2000300)4.82306941
30microtubule severing (GO:0051013)4.79061362
31single fertilization (GO:0007338)4.77319542
32spermatid nucleus differentiation (GO:0007289)4.76277834
33male meiosis I (GO:0007141)4.68114774
34negative regulation of inclusion body assembly (GO:0090084)4.65911345
35microtubule depolymerization (GO:0007019)4.61276463
36sperm capacitation (GO:0048240)4.56756274
37regulation of microtubule-based movement (GO:0060632)4.46274696
38presynaptic membrane assembly (GO:0097105)4.42758673
39DNA methylation involved in gamete generation (GO:0043046)4.36706990
40axoneme assembly (GO:0035082)4.33592147
41nucleobase catabolic process (GO:0046113)4.30905215
42presynaptic membrane organization (GO:0097090)4.27133979
43protein polyglutamylation (GO:0018095)4.24993096
44spermatogenesis (GO:0007283)4.24094942
45male gamete generation (GO:0048232)4.22236026
46axonal fasciculation (GO:0007413)4.17225325
47fertilization (GO:0009566)4.15893437
48cell recognition (GO:0008037)4.08500256
49synaptic vesicle endocytosis (GO:0048488)4.07741642
50regulation of synaptic vesicle transport (GO:1902803)4.07336657
51meiosis I (GO:0007127)3.94829202
52negative regulation of organelle assembly (GO:1902116)3.93708005
53gamma-aminobutyric acid transport (GO:0015812)3.90334472
54gamete generation (GO:0007276)3.88802026
55neurotransmitter secretion (GO:0007269)3.86979795
56synaptic transmission, glutamatergic (GO:0035249)3.83726661
57regulation of synapse structural plasticity (GO:0051823)3.74625624
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73955706
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72629688
60cell migration in hindbrain (GO:0021535)3.70706451
61left/right pattern formation (GO:0060972)3.68914539
62exploration behavior (GO:0035640)3.68177920
63meiotic nuclear division (GO:0007126)3.68135337
64auditory behavior (GO:0031223)3.67853803
65microtubule-based movement (GO:0007018)3.67488334
66cellular process involved in reproduction in multicellular organism (GO:0022412)3.66220395
67germ cell development (GO:0007281)3.63673727
68synapse assembly (GO:0007416)3.62505492
69regulation of inclusion body assembly (GO:0090083)3.59955736
70establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.49007105
71mitochondrion transport along microtubule (GO:0047497)3.49007105
72organic cation transport (GO:0015695)3.48724949
73neurotransmitter-gated ion channel clustering (GO:0072578)3.45474448
74positive regulation of synapse assembly (GO:0051965)3.44928112
75cilium organization (GO:0044782)3.44234334
76cellular potassium ion homeostasis (GO:0030007)3.43909143
77cilium morphogenesis (GO:0060271)3.43229166
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.42999872
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42383046
80neuronal action potential propagation (GO:0019227)3.42192261
81intraciliary transport (GO:0042073)3.42186262
82sodium ion export (GO:0071436)3.40806707
83dendritic spine organization (GO:0097061)3.40691479
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39927041
85transmission of nerve impulse (GO:0019226)3.38706137
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37908238
87locomotory exploration behavior (GO:0035641)3.37580794
88positive regulation of mitochondrial fission (GO:0090141)3.37481391
89regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35453591
90neuron-neuron synaptic transmission (GO:0007270)3.35355065
91chromosome organization involved in meiosis (GO:0070192)3.33966681
92neuronal ion channel clustering (GO:0045161)3.31882661
93response to auditory stimulus (GO:0010996)3.31568607
94cilium assembly (GO:0042384)3.30492436
95nucleoside diphosphate phosphorylation (GO:0006165)3.28309507
96cerebellar granule cell differentiation (GO:0021707)3.23563720
97synaptic vesicle exocytosis (GO:0016079)3.19283220
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18927885
99regulation of neuronal synaptic plasticity (GO:0048168)3.16142826
100cellular component assembly involved in morphogenesis (GO:0010927)3.12455851
101dendrite morphogenesis (GO:0048813)3.08912978
102axon extension (GO:0048675)3.07527579
103protein localization to synapse (GO:0035418)3.06241183
104left/right axis specification (GO:0070986)3.05169322
105neurotransmitter transport (GO:0006836)3.03360304
106calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02268043
107multicellular organismal reproductive process (GO:0048609)3.02056317
108clathrin coat assembly (GO:0048268)3.01665388
109central nervous system projection neuron axonogenesis (GO:0021952)2.98407486
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98085821
111synapse organization (GO:0050808)2.96389111
112regulation of dendritic spine morphogenesis (GO:0061001)2.95004323
113regulation of neurotransmitter levels (GO:0001505)2.94865710
114regulation of vesicle fusion (GO:0031338)2.92561475
115dendritic spine morphogenesis (GO:0060997)2.92018422
116regulation of neurotransmitter secretion (GO:0046928)2.91624245
117mechanosensory behavior (GO:0007638)2.91010437
118regulation of protein kinase A signaling (GO:0010738)2.89807356
119acidic amino acid transport (GO:0015800)2.88699715
120cochlea development (GO:0090102)2.88251456
121organelle transport along microtubule (GO:0072384)2.86456989
122adult walking behavior (GO:0007628)2.84888197
123calcium ion import (GO:0070509)2.83310439
124establishment of synaptic vesicle localization (GO:0097480)2.82590170
125synaptic vesicle transport (GO:0048489)2.82590170
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.82290838
127regulation of respiratory system process (GO:0044065)2.81467501
128amino acid import (GO:0043090)2.80737321
129neuromuscular synaptic transmission (GO:0007274)2.79249451
130meiotic cell cycle (GO:0051321)2.77766408
131regulation of neurotransmitter transport (GO:0051588)2.77397541
132establishment of vesicle localization (GO:0051650)2.75043976
133glutamate secretion (GO:0014047)2.74753317
134startle response (GO:0001964)2.74496182
135regulation of chromatin binding (GO:0035561)2.73881698
136membrane depolarization during action potential (GO:0086010)2.73308153
137seminiferous tubule development (GO:0072520)2.72329900
138regulation of synapse assembly (GO:0051963)2.71747603
139vocalization behavior (GO:0071625)2.70884447
140hippocampus development (GO:0021766)2.70730692
141neuron projection extension (GO:1990138)2.69254839
142layer formation in cerebral cortex (GO:0021819)2.68868971
143regulation of acrosome reaction (GO:0060046)2.67707364
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67630581
145cell communication by electrical coupling (GO:0010644)2.66459679
146microtubule bundle formation (GO:0001578)2.65978742
147regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65930574
148glycosphingolipid biosynthetic process (GO:0006688)2.65898427
149regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64840962
150ionotropic glutamate receptor signaling pathway (GO:0035235)2.64193346
151neuron recognition (GO:0008038)2.63851442
152negative regulation of microtubule polymerization (GO:0031115)2.63823280
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61813155
154cytoskeleton-dependent intracellular transport (GO:0030705)2.61597122
155neurofilament cytoskeleton organization (GO:0060052)2.61188808
156positive regulation of membrane potential (GO:0045838)2.60746907
157negative regulation of axonogenesis (GO:0050771)2.60311692
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59674211
159lactate metabolic process (GO:0006089)2.59658011
160retinal ganglion cell axon guidance (GO:0031290)2.58967940
161regulation of postsynaptic membrane potential (GO:0060078)2.58095915
162cerebral cortex radially oriented cell migration (GO:0021799)2.57571338
163urinary tract smooth muscle contraction (GO:0014848)2.57216196
164nonmotile primary cilium assembly (GO:0035058)2.56036454
165GTP biosynthetic process (GO:0006183)2.55990388
166rRNA catabolic process (GO:0016075)2.53066624
167neuron cell-cell adhesion (GO:0007158)2.50459221
168glutamate receptor signaling pathway (GO:0007215)2.50293484
169multicellular organismal development (GO:0007275)2.49280012
170regulation of glutamate receptor signaling pathway (GO:1900449)2.42030650
171synaptic vesicle maturation (GO:0016188)2.38461725
172genitalia morphogenesis (GO:0035112)2.37804093
173positive regulation of synapse maturation (GO:0090129)2.37228825
174positive regulation of dendritic spine morphogenesis (GO:0061003)2.36876702
175G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.35315880
176regulation of calcium ion-dependent exocytosis (GO:0017158)2.32277406
177response to acidic pH (GO:0010447)2.31505071
178synaptic vesicle docking involved in exocytosis (GO:0016081)2.31354042
179mating behavior (GO:0007617)2.30802261
180cilium or flagellum-dependent cell motility (GO:0001539)10.9218904
181axonemal dynein complex assembly (GO:0070286)10.0718791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.12023318
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.16844701
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31170668
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83420494
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82934622
6REST_21632747_ChIP-Seq_MESCs_Mouse2.39786759
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22193677
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17946794
9ZNF274_21170338_ChIP-Seq_K562_Hela2.09901669
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97713242
11CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95444008
12SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91215963
13GBX2_23144817_ChIP-Seq_PC3_Human1.90064235
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88087432
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87222926
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.86659226
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82008122
18VDR_22108803_ChIP-Seq_LS180_Human1.81609883
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.80276165
20IGF1R_20145208_ChIP-Seq_DFB_Human1.77306711
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77267828
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.73848888
23DROSHA_22980978_ChIP-Seq_HELA_Human1.66044403
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65025787
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.64853430
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64106505
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61119156
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.60065752
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57458738
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54536861
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54004299
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51273805
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.49840761
34* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47593203
35* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46033525
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43805300
37RNF2_27304074_Chip-Seq_NSC_Mouse1.43515262
38* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43415269
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.43196472
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40300155
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39443283
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39443283
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38695956
44SMAD4_21799915_ChIP-Seq_A2780_Human1.38070718
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37355272
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35107043
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34591338
48TAF15_26573619_Chip-Seq_HEK293_Human1.34365291
49TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32850872
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31857173
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.31766735
52KDM2B_26808549_Chip-Seq_REH_Human1.30849665
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30660692
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30118270
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30109733
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30083293
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30083293
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30012739
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25554767
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23171124
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22930445
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21809527
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.21616787
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19982150
65CBP_20019798_ChIP-Seq_JUKART_Human1.19982150
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18874460
67CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13224468
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12127351
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.11444483
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11257626
71* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10944209
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10932325
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.10228566
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10081782
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09159576
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09121630
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08866718
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.07968498
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.07860807
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06318405
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06242611
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.06199476
83P300_19829295_ChIP-Seq_ESCs_Human1.06128168
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05488089
85* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05253818
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04438042
87AR_19668381_ChIP-Seq_PC3_Human1.03902655
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.03727476
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03498633
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03485799
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02568263
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01610418
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.00958838
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00810768
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00725535
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00329425
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00065140
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.00026267
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99593159
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99509311
101* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99495859
102ER_23166858_ChIP-Seq_MCF-7_Human0.99472044
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.98373783
104FUS_26573619_Chip-Seq_HEK293_Human0.97589760
105SOX2_21211035_ChIP-Seq_LN229_Gbm0.97317947
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97260009
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96771521
108SOX9_26525672_Chip-Seq_HEART_Mouse0.96262937
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96124286
110TCF4_23295773_ChIP-Seq_U87_Human0.94942565
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92777879
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92540569
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91609544
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91177491
115AR_21572438_ChIP-Seq_LNCaP_Human0.90550086
116AR_25329375_ChIP-Seq_VCAP_Human0.90337983
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90329459
118HTT_18923047_ChIP-ChIP_STHdh_Human0.90314743
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90254789
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89572717
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88287549
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.88213964
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88071545
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87876344
125* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87257309
126SOX2_22085726_ChIP-Seq_NPCs_Mouse0.86202725
127KLF4_19829295_ChIP-Seq_ESCs_Human0.85420351
128P53_22387025_ChIP-Seq_ESCs_Mouse0.84286796
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83948300
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83625955
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81394650
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80884435
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80776715
134JUN_21703547_ChIP-Seq_K562_Human0.80614613
135POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.80455146
136* SOX2_16153702_ChIP-ChIP_HESCs_Human0.80295094
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80198292
138* GF1_26923725_Chip-Seq_HPCs_Mouse0.80024847
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79893220
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79689077
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79473038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.38522315
2MP0003698_abnormal_male_reproductive3.44110542
3MP0004859_abnormal_synaptic_plasticity3.34956459
4MP0003880_abnormal_central_pattern3.31157777
5MP0008877_abnormal_DNA_methylation3.25361968
6MP0001929_abnormal_gametogenesis2.94507192
7MP0001984_abnormal_olfaction2.91975320
8MP0002822_catalepsy2.84226382
9MP0002653_abnormal_ependyma_morphology2.82462629
10MP0003635_abnormal_synaptic_transmissio2.59419565
11MP0001968_abnormal_touch/_nociception2.49784640
12MP0009046_muscle_twitch2.43049090
13MP0002102_abnormal_ear_morphology2.39889097
14MP0002735_abnormal_chemical_nociception2.39193859
15MP0002063_abnormal_learning/memory/cond2.26312543
16MP0005645_abnormal_hypothalamus_physiol2.24176394
17MP0004270_analgesia2.22432268
18MP0009745_abnormal_behavioral_response2.18615007
19MP0006276_abnormal_autonomic_nervous2.13400055
20MP0002736_abnormal_nociception_after2.05479716
21MP0002210_abnormal_sex_determination1.99006015
22MP0001440_abnormal_grooming_behavior1.98451689
23MP0002572_abnormal_emotion/affect_behav1.97702328
24MP0002064_seizures1.96434006
25MP0005394_taste/olfaction_phenotype1.94428703
26MP0005499_abnormal_olfactory_system1.94428703
27MP0005423_abnormal_somatic_nervous1.87165512
28MP0002161_abnormal_fertility/fecundity1.85432604
29MP0008789_abnormal_olfactory_epithelium1.84679564
30MP0002272_abnormal_nervous_system1.80206493
31MP0001145_abnormal_male_reproductive1.76793354
32MP0000013_abnormal_adipose_tissue1.71935936
33MP0003787_abnormal_imprinting1.69203983
34MP0001486_abnormal_startle_reflex1.64849918
35MP0002160_abnormal_reproductive_system1.63350368
36MP0001188_hyperpigmentation1.57466070
37MP0002734_abnormal_mechanical_nocicepti1.56718260
38MP0000778_abnormal_nervous_system1.56438562
39MP0003329_amyloid_beta_deposits1.55789960
40MP0003878_abnormal_ear_physiology1.54761602
41MP0005377_hearing/vestibular/ear_phenot1.54761602
42MP0002234_abnormal_pharynx_morphology1.54080407
43MP0002733_abnormal_thermal_nociception1.51447090
44MP0005623_abnormal_meninges_morphology1.47622083
45MP0000653_abnormal_sex_gland1.47298043
46MP0002067_abnormal_sensory_capabilities1.46580461
47MP0003879_abnormal_hair_cell1.44623371
48MP0004742_abnormal_vestibular_system1.42471325
49MP0002638_abnormal_pupillary_reflex1.37182289
50MP0004885_abnormal_endolymph1.35201982
51MP0002184_abnormal_innervation1.34573399
52MP0001970_abnormal_pain_threshold1.33865822
53MP0002557_abnormal_social/conspecific_i1.30373885
54MP0004811_abnormal_neuron_physiology1.26726543
55MP0002282_abnormal_trachea_morphology1.25883526
56MP0005409_darkened_coat_color1.24371684
57MP0000751_myopathy1.20850983
58MP0000631_abnormal_neuroendocrine_gland1.19908403
59MP0005389_reproductive_system_phenotype1.14612622
60MP0005248_abnormal_Harderian_gland1.13148516
61MP0002882_abnormal_neuron_morphology1.12030252
62MP0005187_abnormal_penis_morphology1.10154242
63MP0004133_heterotaxia1.10047974
64MP0001529_abnormal_vocalization1.09851584
65MP0004924_abnormal_behavior1.09227639
66MP0005386_behavior/neurological_phenoty1.09227639
67MP0000955_abnormal_spinal_cord1.08721774
68MP0002152_abnormal_brain_morphology1.07785823
69MP0001299_abnormal_eye_distance/1.03190390
70MP0008569_lethality_at_weaning1.01356356
71MP0000566_synostosis0.99245105
72MP0000049_abnormal_middle_ear0.97684999
73MP0003122_maternal_imprinting0.97450337
74MP0002928_abnormal_bile_duct0.92774415
75MP0005551_abnormal_eye_electrophysiolog0.92446712
76MP0001905_abnormal_dopamine_level0.90790021
77MP0001765_abnormal_ion_homeostasis0.89266668
78MP0002066_abnormal_motor_capabilities/c0.88864786
79MP0003633_abnormal_nervous_system0.87295732
80MP0003938_abnormal_ear_development0.86671168
81MP0009780_abnormal_chondrocyte_physiolo0.86296003
82MP0001919_abnormal_reproductive_system0.85851744
83MP0001485_abnormal_pinna_reflex0.85729631
84MP0002751_abnormal_autonomic_nervous0.85200801
85MP0001177_atelectasis0.84729842
86MP0005646_abnormal_pituitary_gland0.83671117
87MP0003632_abnormal_nervous_system0.83038080
88MP0008872_abnormal_physiological_respon0.79455735
89MP0003861_abnormal_nervous_system0.78777323
90MP0002909_abnormal_adrenal_gland0.78173337
91MP0000604_amyloidosis0.77608744
92MP0002837_dystrophic_cardiac_calcinosis0.77401531
93MP0002229_neurodegeneration0.77062161
94MP0002233_abnormal_nose_morphology0.76999590
95MP0001501_abnormal_sleep_pattern0.75952643
96MP0002752_abnormal_somatic_nervous0.75635473
97MP0003634_abnormal_glial_cell0.75378773
98MP0006072_abnormal_retinal_apoptosis0.75357397
99MP0003631_nervous_system_phenotype0.74796066
100MP0002938_white_spotting0.73879590
101MP0001502_abnormal_circadian_rhythm0.73224828
102MP0002249_abnormal_larynx_morphology0.71793242
103MP0003690_abnormal_glial_cell0.71406252
104MP0000569_abnormal_digit_pigmentation0.69397429
105MP0002081_perinatal_lethality0.67968019
106MP0004142_abnormal_muscle_tone0.67250516
107MP0000920_abnormal_myelination0.66885793
108MP0000534_abnormal_ureter_morphology0.66257109
109MP0003221_abnormal_cardiomyocyte_apopto0.64802966
110MP0003385_abnormal_body_wall0.64690827
111MP0001943_abnormal_respiration0.64584807
112MP0000537_abnormal_urethra_morphology0.64143496
113MP0003942_abnormal_urinary_system0.63232720
114MP0002090_abnormal_vision0.63012836
115MP0003119_abnormal_digestive_system0.62850589
116MP0000462_abnormal_digestive_system0.62346979
117MP0010770_preweaning_lethality0.62047290
118MP0002082_postnatal_lethality0.62047290
119MP0010769_abnormal_survival0.61357583
120MP0005397_hematopoietic_system_phenotyp0.58839689
121MP0001545_abnormal_hematopoietic_system0.58839689
122MP0000003_abnormal_adipose_tissue0.57821685
123MP0003121_genomic_imprinting0.55752727
124MP0001963_abnormal_hearing_physiology0.54876485
125MP0005195_abnormal_posterior_eye0.54660454
126MP0006292_abnormal_olfactory_placode0.52793059
127MP0000026_abnormal_inner_ear0.50402320
128MP0002069_abnormal_eating/drinking_beha0.49584304
129MP0005253_abnormal_eye_physiology0.48623531

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.43117633
2Abnormal ciliary motility (HP:0012262)8.65175662
3Abnormal respiratory epithelium morphology (HP:0012253)8.03005125
4Abnormal respiratory motile cilium morphology (HP:0005938)8.03005125
5Rhinitis (HP:0012384)7.33163257
6Chronic bronchitis (HP:0004469)5.69563142
7Infertility (HP:0000789)5.18816660
8Nasal polyposis (HP:0100582)4.84625721
9Bronchiectasis (HP:0002110)4.05486767
10Abnormality of the nasal mucosa (HP:0000433)3.89753044
11Nephronophthisis (HP:0000090)3.56023640
12Medial flaring of the eyebrow (HP:0010747)3.38696674
13Ankle clonus (HP:0011448)3.36647299
14Abnormality of the lower motor neuron (HP:0002366)3.32511611
15Cortical dysplasia (HP:0002539)3.24918788
16Spastic gait (HP:0002064)3.24780841
17Abnormal eating behavior (HP:0100738)3.22152652
18Split foot (HP:0001839)3.19114558
19Focal motor seizures (HP:0011153)3.11386537
20Action tremor (HP:0002345)2.99894161
21Urinary urgency (HP:0000012)2.97890887
22Myokymia (HP:0002411)2.94534126
23Abnormality of midbrain morphology (HP:0002418)2.94375788
24Molar tooth sign on MRI (HP:0002419)2.94375788
25Abnormality of the corticospinal tract (HP:0002492)2.94021464
26Bronchitis (HP:0012387)2.92505889
27Visual hallucinations (HP:0002367)2.82164077
28Drooling (HP:0002307)2.80325792
29Amyotrophic lateral sclerosis (HP:0007354)2.72279459
30Focal seizures (HP:0007359)2.71719315
31Hemiparesis (HP:0001269)2.68448099
32Gait imbalance (HP:0002141)2.65245141
33Epileptiform EEG discharges (HP:0011182)2.64781527
34Generalized tonic-clonic seizures (HP:0002069)2.64548547
35Failure to thrive in infancy (HP:0001531)2.63229821
36Progressive cerebellar ataxia (HP:0002073)2.59456563
37EEG with generalized epileptiform discharges (HP:0011198)2.57643340
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.56582656
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56582656
40Hypsarrhythmia (HP:0002521)2.54540128
41Excessive salivation (HP:0003781)2.52729566
42Abnormality of the renal medulla (HP:0100957)2.50985368
43Fibular hypoplasia (HP:0003038)2.49944601
44Neurofibrillary tangles (HP:0002185)2.48438503
45Recurrent sinusitis (HP:0011108)2.45848531
46Male infertility (HP:0003251)2.44328373
47Recurrent otitis media (HP:0000403)2.40926877
48Lower limb muscle weakness (HP:0007340)2.39583739
49Congenital primary aphakia (HP:0007707)2.37877012
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37419581
51Mutism (HP:0002300)2.31917967
52Sleep apnea (HP:0010535)2.31583387
53Peripheral hypomyelination (HP:0007182)2.29823164
54Chronic sinusitis (HP:0011109)2.29724364
55Urinary bladder sphincter dysfunction (HP:0002839)2.21059131
56Atrophy/Degeneration involving motor neurons (HP:0007373)2.17447099
57Hand muscle atrophy (HP:0009130)2.17169417
58Nephrogenic diabetes insipidus (HP:0009806)2.15787865
59Intention tremor (HP:0002080)2.14929239
60Spastic tetraplegia (HP:0002510)2.12653682
61Oculomotor apraxia (HP:0000657)2.11129258
62Retinal dysplasia (HP:0007973)2.10060755
63Shoulder girdle muscle weakness (HP:0003547)2.07756449
64Morphological abnormality of the pyramidal tract (HP:0002062)2.04531392
65Hammertoe (HP:0001765)2.02968926
66Heterochromia iridis (HP:0001100)2.02767911
67Tubulointerstitial nephritis (HP:0001970)2.00512993
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.0689356
69Dynein arm defect of respiratory motile cilia (HP:0012255)10.2719580
70Absent/shortened dynein arms (HP:0200106)10.2719580
71Abnormality of the musculature of the pelvis (HP:0001469)1.99968403
72Abnormality of the hip-girdle musculature (HP:0001445)1.99968403
73Hypoplasia of the corpus callosum (HP:0002079)1.99800191
74Torticollis (HP:0000473)1.98744229
75Supranuclear gaze palsy (HP:0000605)1.96755223
76Gaze-evoked nystagmus (HP:0000640)1.96419776
77Poor suck (HP:0002033)1.95286551
78Dysmetria (HP:0001310)1.89629235
79Esotropia (HP:0000565)1.89154962
80Absent speech (HP:0001344)1.88317618
81Epileptic encephalopathy (HP:0200134)1.87185933
82Abnormality of binocular vision (HP:0011514)1.86963109
83Diplopia (HP:0000651)1.86963109
84Oligodactyly (hands) (HP:0001180)1.86503619
85Oligodactyly (HP:0012165)1.85460985
86Aplasia/Hypoplasia of the lens (HP:0008063)1.84888907
87Termporal pattern (HP:0011008)1.84523878
88Insidious onset (HP:0003587)1.84523878
89Insomnia (HP:0100785)1.82735140
90Pheochromocytoma (HP:0002666)1.82368182
91Abnormality of the labia minora (HP:0012880)1.82163953
92Postaxial hand polydactyly (HP:0001162)1.80938395
93Genital tract atresia (HP:0001827)1.80092633
94Broad foot (HP:0001769)1.79958326
95Amblyopia (HP:0000646)1.79712578
96Sensory axonal neuropathy (HP:0003390)1.78428352
97Vaginal atresia (HP:0000148)1.75862290
98Apathy (HP:0000741)1.75050434
99Hyperventilation (HP:0002883)1.75039250
100Occipital encephalocele (HP:0002085)1.74550335
101Tubular atrophy (HP:0000092)1.73708152
102Tubulointerstitial abnormality (HP:0001969)1.73602431
103Neuronal loss in central nervous system (HP:0002529)1.73087787
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72936145
105Hypoplasia of the brainstem (HP:0002365)1.72936145
106Paraplegia (HP:0010550)1.71805250
107Cerebral hypomyelination (HP:0006808)1.71053556
108Abnormality of the motor neurons (HP:0002450)1.69962694
109Abnormal neuron morphology (HP:0012757)1.69962694
110Ulnar claw (HP:0001178)1.68364459
111Aplasia/Hypoplasia of the fibula (HP:0006492)1.68041090
112Abnormal drinking behavior (HP:0030082)1.66742829
113Polydipsia (HP:0001959)1.66742829
114Clonus (HP:0002169)1.66045042
115Distal upper limb amyotrophy (HP:0007149)1.65714333
116Upper limb amyotrophy (HP:0009129)1.65714333
117Optic nerve hypoplasia (HP:0000609)1.65610904
118Broad-based gait (HP:0002136)1.64989471
119Postaxial foot polydactyly (HP:0001830)1.64693588
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64468750
121Stage 5 chronic kidney disease (HP:0003774)1.64083638
122Poor coordination (HP:0002370)1.63587040
123Narrow forehead (HP:0000341)1.61036856
124Median cleft lip (HP:0000161)1.59425883
125Abnormal gallbladder physiology (HP:0012438)1.58699091
126Cholecystitis (HP:0001082)1.58699091
127Cerebral inclusion bodies (HP:0100314)1.58003488
128Bifid tongue (HP:0010297)1.56694678
129Progressive inability to walk (HP:0002505)1.54871413
130Specific learning disability (HP:0001328)1.52078890
131Abnormality of ocular smooth pursuit (HP:0000617)1.51669348
132Impaired vibration sensation in the lower limbs (HP:0002166)1.51485728
133Impaired proprioception (HP:0010831)1.47940148
134J-shaped sella turcica (HP:0002680)1.47699349
135Polyphagia (HP:0002591)1.44948622
136Pancreatic fibrosis (HP:0100732)1.44587669
137True hermaphroditism (HP:0010459)1.42971068
138Abnormality of saccadic eye movements (HP:0000570)1.41983818
139Febrile seizures (HP:0002373)1.41603239
140Asthma (HP:0002099)1.40684379
141Tubulointerstitial fibrosis (HP:0005576)1.40205647
142Lissencephaly (HP:0001339)1.39058004
143Absence seizures (HP:0002121)1.38859389
144Atonic seizures (HP:0010819)1.38715091
145Choroideremia (HP:0001139)1.38365803
146Agitation (HP:0000713)1.37411168
147Pelvic girdle muscle weakness (HP:0003749)1.36734441
148Truncal ataxia (HP:0002078)1.36475537
149Widely spaced teeth (HP:0000687)1.36254105
150Congenital hepatic fibrosis (HP:0002612)1.35583108
151Highly arched eyebrow (HP:0002553)1.35572248
152Renal dysplasia (HP:0000110)1.34040027
153Decreased central vision (HP:0007663)1.33689739
154Narrow nasal bridge (HP:0000446)1.33565379
155Limb dystonia (HP:0002451)1.32123044
156Cystic liver disease (HP:0006706)1.31738816
157Anxiety (HP:0000739)1.31589332
158Pachygyria (HP:0001302)1.31029798
159Delusions (HP:0000746)1.30962941
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.30486425
161Impaired smooth pursuit (HP:0007772)1.29751434
162Depression (HP:0000716)1.29408561
163Limb ataxia (HP:0002070)1.29345684
164Dialeptic seizures (HP:0011146)1.28981593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.22087768
2PDK46.22087768
3PNCK3.73859051
4PDK23.53386744
5TESK13.21666901
6PRKD32.99802051
7MARK12.31885283
8ICK2.23899062
9PTK2B2.20167947
10CSNK1G22.08279091
11MAP3K41.97685115
12NTRK31.94709174
13MAPK151.90754633
14TRIM281.90089277
15CSNK1G31.82379736
16SIK21.82087116
17MAP2K71.81897971
18LIMK11.74806378
19MAP4K21.71796226
20ADRBK21.70971404
21CASK1.68212634
22CSNK1A1L1.64925876
23RIPK41.57366068
24STK161.53835415
25MINK11.50468996
26WNK41.49999000
27STK391.42336615
28EPHA31.42233192
29EPHB21.39276708
30MAP2K41.36556819
31CSNK1G11.36202619
32GRK51.36054823
33IRAK21.30438175
34LMTK21.25538575
35NTRK21.25533528
36STK381.17639321
37EPHB11.17593681
38MAP3K91.15143091
39KSR11.14723706
40DAPK21.13770006
41MAPK131.12931627
42UHMK11.10082660
43PLK21.09631215
44PAK61.07837823
45EPHA41.04610606
46ARAF1.04182419
47TYRO31.00899145
48PHKG20.96256768
49PHKG10.96256768
50NEK20.95918677
51PRKCG0.94407181
52CAMKK10.94174189
53CDK50.88466339
54BCKDK0.87343523
55FES0.86845492
56BRAF0.85765721
57GRK70.85319589
58LATS20.83201755
59CDK190.82305234
60CAMK2G0.79522898
61NTRK10.78593151
62SIK30.73274159
63ERBB30.73036444
64MAP3K120.72985359
65PINK10.71822896
66ROCK20.71678020
67CAMK1G0.70064494
68CDK180.69979302
69SRPK10.68731426
70PDK10.67477979
71CDK150.66048088
72RPS6KA40.65357138
73TNIK0.64407487
74CDK140.64312796
75CAMK2D0.63102110
76BMPR20.62541790
77PKN10.61874676
78STK110.61863284
79CAMK2A0.61516674
80TESK20.61419381
81PRKCE0.61206614
82FGR0.60225975
83KSR20.60171473
84ADRBK10.59702625
85PIM20.59445522
86RIPK10.58085905
87DYRK20.57564794
88MAP3K110.53848717
89CDK11A0.53666198
90DAPK10.52090014
91CAMK10.50851308
92RAF10.49017357
93DYRK1A0.48469458
94WNK10.47691314
95TSSK60.46632877
96MOS0.44468262
97BMPR1B0.42854995
98BCR0.42750755
99MAP2K10.42537918
100MARK20.41812821
101CAMK40.41194971
102MAP2K60.40531972
103CAMK2B0.40494230
104PAK30.39589323
105CSNK1D0.38573997
106DYRK1B0.37492415
107CAMKK20.37300804
108MAP3K100.36946607
109CSNK1A10.34765270
110MAPK90.34722192
111OXSR10.34307572
112PDPK10.33973874
113PRKCH0.33703358
114DYRK30.33084820
115NME10.31762003
116CCNB10.30098463
117CSNK1E0.29763020
118MAP3K60.29500828
119GRK60.28974638
120BRSK10.27986075
121PDGFRA0.27595250
122RPS6KA30.27138346
123RET0.26958995
124MAP3K50.26795523
125ERBB20.26564930
126MAPK100.26454115
127SRC0.25988975
128PRKCZ0.25823819
129CDC70.25555821
130RPS6KA20.25471777
131PRKG10.23993068
132WNK30.22962810
133PRKACA0.22346836
134SGK4940.21389390
135SGK2230.21389390
136TAOK10.20854583
137STK30.18961502
138PRKCQ0.17968235

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.05929664
2Nicotine addiction_Homo sapiens_hsa050332.92973924
3Olfactory transduction_Homo sapiens_hsa047402.75947347
4Amphetamine addiction_Homo sapiens_hsa050312.53707114
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.51502898
6Long-term potentiation_Homo sapiens_hsa047202.46599931
7Collecting duct acid secretion_Homo sapiens_hsa049662.45555623
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42227829
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08128383
10Circadian entrainment_Homo sapiens_hsa047132.07927398
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07575071
12Dopaminergic synapse_Homo sapiens_hsa047282.01736984
13Huntingtons disease_Homo sapiens_hsa050161.98084273
14Renin secretion_Homo sapiens_hsa049241.95333336
15Pyruvate metabolism_Homo sapiens_hsa006201.93488419
16Taste transduction_Homo sapiens_hsa047421.92076971
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89381409
18Glutamatergic synapse_Homo sapiens_hsa047241.87485493
19Morphine addiction_Homo sapiens_hsa050321.78711051
20Insulin secretion_Homo sapiens_hsa049111.77522471
21Glucagon signaling pathway_Homo sapiens_hsa049221.71995249
22Dorso-ventral axis formation_Homo sapiens_hsa043201.70703106
23Salivary secretion_Homo sapiens_hsa049701.68418019
24Steroid biosynthesis_Homo sapiens_hsa001001.67602679
25Calcium signaling pathway_Homo sapiens_hsa040201.57146224
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56738109
27GABAergic synapse_Homo sapiens_hsa047271.56322666
28Gastric acid secretion_Homo sapiens_hsa049711.56092131
29Cocaine addiction_Homo sapiens_hsa050301.55934316
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53797181
31Oocyte meiosis_Homo sapiens_hsa041141.49527703
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46492082
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43430775
34Oxidative phosphorylation_Homo sapiens_hsa001901.42752382
35Estrogen signaling pathway_Homo sapiens_hsa049151.40566328
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38590383
37Cholinergic synapse_Homo sapiens_hsa047251.36570149
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35715611
39Cardiac muscle contraction_Homo sapiens_hsa042601.34850177
40Alzheimers disease_Homo sapiens_hsa050101.31801750
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26622710
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24771491
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24213199
44Oxytocin signaling pathway_Homo sapiens_hsa049211.23603601
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20621073
46Long-term depression_Homo sapiens_hsa047301.20115581
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16757392
48Axon guidance_Homo sapiens_hsa043601.15212499
49Fatty acid biosynthesis_Homo sapiens_hsa000611.14921442
50Parkinsons disease_Homo sapiens_hsa050121.07982873
51Serotonergic synapse_Homo sapiens_hsa047261.07174451
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05724400
53Vibrio cholerae infection_Homo sapiens_hsa051101.05416586
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05247558
55Gap junction_Homo sapiens_hsa045401.03172618
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02085556
57GnRH signaling pathway_Homo sapiens_hsa049121.01898578
58Phototransduction_Homo sapiens_hsa047440.99021710
59Hippo signaling pathway_Homo sapiens_hsa043900.98720444
60VEGF signaling pathway_Homo sapiens_hsa043700.98292881
61cAMP signaling pathway_Homo sapiens_hsa040240.98211906
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97925045
63Alcoholism_Homo sapiens_hsa050340.96271770
64Melanogenesis_Homo sapiens_hsa049160.94896750
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91040525
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90068723
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89910352
68Vitamin B6 metabolism_Homo sapiens_hsa007500.88768755
69Circadian rhythm_Homo sapiens_hsa047100.88671477
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87228751
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86230778
72Sulfur metabolism_Homo sapiens_hsa009200.83167527
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81145709
74Inositol phosphate metabolism_Homo sapiens_hsa005620.80646847
75Basal transcription factors_Homo sapiens_hsa030220.79580537
76Type II diabetes mellitus_Homo sapiens_hsa049300.74503087
77Basal cell carcinoma_Homo sapiens_hsa052170.72524283
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.72247783
79Thyroid hormone synthesis_Homo sapiens_hsa049180.71558630
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71469246
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71240573
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69870907
83Glioma_Homo sapiens_hsa052140.69806695
84Dilated cardiomyopathy_Homo sapiens_hsa054140.67401554
85Fatty acid elongation_Homo sapiens_hsa000620.66844864
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66739546
87Butanoate metabolism_Homo sapiens_hsa006500.66539001
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63353357
89Biosynthesis of amino acids_Homo sapiens_hsa012300.63210078
90Regulation of autophagy_Homo sapiens_hsa041400.62129158
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61351483
92ErbB signaling pathway_Homo sapiens_hsa040120.60655317
93Hedgehog signaling pathway_Homo sapiens_hsa043400.59628652
94Pancreatic secretion_Homo sapiens_hsa049720.58605982
95Tight junction_Homo sapiens_hsa045300.54327943
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50663086
97Protein export_Homo sapiens_hsa030600.47995957
98Wnt signaling pathway_Homo sapiens_hsa043100.47744517
99Arginine and proline metabolism_Homo sapiens_hsa003300.47224283
100MAPK signaling pathway_Homo sapiens_hsa040100.45072522
101Glycerolipid metabolism_Homo sapiens_hsa005610.43743038
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42890295
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.42682188
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42596622
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.40310194
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39809572
107Prion diseases_Homo sapiens_hsa050200.39782240
108Notch signaling pathway_Homo sapiens_hsa043300.38767694
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37310498
110Endocytosis_Homo sapiens_hsa041440.36588601
111Choline metabolism in cancer_Homo sapiens_hsa052310.35702879
112Propanoate metabolism_Homo sapiens_hsa006400.34542513
113Endometrial cancer_Homo sapiens_hsa052130.34183157
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.34014679
115African trypanosomiasis_Homo sapiens_hsa051430.33778265
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33396138
117T cell receptor signaling pathway_Homo sapiens_hsa046600.32994065
118Ras signaling pathway_Homo sapiens_hsa040140.32160704
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30941177
120Salmonella infection_Homo sapiens_hsa051320.30131080
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.29640122
122Phagosome_Homo sapiens_hsa041450.29578220
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28410001
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27266068
125Insulin signaling pathway_Homo sapiens_hsa049100.26695876
126Rap1 signaling pathway_Homo sapiens_hsa040150.26373312
127Systemic lupus erythematosus_Homo sapiens_hsa053220.26158974
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.24881404
129AMPK signaling pathway_Homo sapiens_hsa041520.23645291
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22763308

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