PNLDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.06594386
2regulation of female gonad development (GO:2000194)8.98088681
3synapsis (GO:0007129)7.85653448
4oocyte development (GO:0048599)7.64228931
5multicellular organism reproduction (GO:0032504)7.60825883
6regulation of DNA methylation (GO:0044030)6.95531102
7meiotic cell cycle (GO:0051321)6.83951713
8female gamete generation (GO:0007292)6.47520547
9retinal cone cell development (GO:0046549)6.07352928
10regulation of histone H3-K9 methylation (GO:0051570)6.02450405
11negative regulation of reproductive process (GO:2000242)5.90175620
12positive regulation of humoral immune response (GO:0002922)5.87334024
13protein kinase C signaling (GO:0070528)5.63069128
14mitotic metaphase plate congression (GO:0007080)5.48153723
15gene silencing by RNA (GO:0031047)5.47443120
16positive regulation of meiosis (GO:0045836)5.44810567
17binding of sperm to zona pellucida (GO:0007339)5.41608646
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.36638901
19reproduction (GO:0000003)5.35545919
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.21534696
21positive regulation of meiotic cell cycle (GO:0051446)5.13764609
22purine nucleobase biosynthetic process (GO:0009113)4.97305889
23fertilization (GO:0009566)4.85294688
24piRNA metabolic process (GO:0034587)4.83702732
25nucleobase biosynthetic process (GO:0046112)4.72380670
26DNA replication checkpoint (GO:0000076)4.69704241
27metaphase plate congression (GO:0051310)4.55020619
28regulation of retinoic acid receptor signaling pathway (GO:0048385)4.54937397
29DNA alkylation (GO:0006305)4.52348698
30DNA methylation (GO:0006306)4.52348698
31regulation of meiosis (GO:0040020)4.51291337
32sperm-egg recognition (GO:0035036)4.38597038
33protein localization to kinetochore (GO:0034501)4.35726567
34synaptonemal complex assembly (GO:0007130)4.32819781
35nuclear pore organization (GO:0006999)4.29986887
36meiotic chromosome segregation (GO:0045132)4.27475668
37ribosome biogenesis (GO:0042254)4.25189477
38positive regulation of histone H3-K4 methylation (GO:0051571)4.21973605
39ribosome assembly (GO:0042255)4.20607033
40DNA replication initiation (GO:0006270)4.16146579
41regulation of spindle organization (GO:0090224)4.15563945
42citrulline biosynthetic process (GO:0019240)4.13567640
43oogenesis (GO:0048477)4.12758622
44regulation of meiotic cell cycle (GO:0051445)4.10468007
45DNA methylation involved in gamete generation (GO:0043046)4.06237613
46glycine transport (GO:0015816)4.06174209
47gonadal mesoderm development (GO:0007506)4.04622171
48nuclear pore complex assembly (GO:0051292)4.03032778
49negative regulation of histone methylation (GO:0031061)3.99452350
50sister chromatid cohesion (GO:0007062)3.97621418
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95698189
52regulation of meiosis I (GO:0060631)3.94685396
53protein K6-linked ubiquitination (GO:0085020)3.94270339
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.91618272
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88899135
56positive regulation of chromosome segregation (GO:0051984)3.88751853
57mitotic nuclear envelope disassembly (GO:0007077)3.88445402
58synaptonemal complex organization (GO:0070193)3.85364897
59attachment of spindle microtubules to kinetochore (GO:0008608)3.84606734
60regulation of hypersensitivity (GO:0002883)3.84407966
61single fertilization (GO:0007338)3.81327333
62regulation of steroid hormone secretion (GO:2000831)3.81194356
63regulation of mitotic spindle organization (GO:0060236)3.76640067
64folic acid metabolic process (GO:0046655)3.76594369
65DNA replication-dependent nucleosome organization (GO:0034723)3.75073327
66DNA replication-dependent nucleosome assembly (GO:0006335)3.75073327
67protein localization to chromosome, centromeric region (GO:0071459)3.71940605
68kinetochore assembly (GO:0051382)3.68510841
69reciprocal meiotic recombination (GO:0007131)3.66221288
70reciprocal DNA recombination (GO:0035825)3.66221288
71chromatin remodeling at centromere (GO:0031055)3.65728297
72establishment of chromosome localization (GO:0051303)3.63984245
73oocyte maturation (GO:0001556)3.60672785
74mitotic sister chromatid segregation (GO:0000070)3.60215910
75kinetochore organization (GO:0051383)3.59843863
76nuclear envelope disassembly (GO:0051081)3.59546682
77membrane disassembly (GO:0030397)3.59546682
78regulation of posttranscriptional gene silencing (GO:0060147)3.58355970
79regulation of gene silencing by miRNA (GO:0060964)3.58355970
80regulation of gene silencing by RNA (GO:0060966)3.58355970
81positive regulation of reproductive process (GO:2000243)3.58017982
82rRNA modification (GO:0000154)3.57902978
83DNA strand elongation involved in DNA replication (GO:0006271)3.56352604
84cell-cell recognition (GO:0009988)3.55403500
85regulation of chromosome segregation (GO:0051983)3.52715050
86negative regulation of chromosome segregation (GO:0051985)3.51410772
87formation of translation preinitiation complex (GO:0001731)3.50658379
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.50412933
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50412933
90phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.50080056
91spindle checkpoint (GO:0031577)3.47860305
92CENP-A containing nucleosome assembly (GO:0034080)3.47084321
93mitotic chromosome condensation (GO:0007076)3.46648658
94maturation of SSU-rRNA (GO:0030490)3.46203182
95germ cell development (GO:0007281)3.42636374
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41665497
97negative regulation of sister chromatid segregation (GO:0033046)3.41665497
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.41665497
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41665497
100meiotic nuclear division (GO:0007126)3.41589933
101resolution of meiotic recombination intermediates (GO:0000712)3.40977268
102maturation of 5.8S rRNA (GO:0000460)3.40146740
103regulation of calcium ion-dependent exocytosis (GO:0017158)3.38874325
104regulation of double-strand break repair via homologous recombination (GO:0010569)3.38541692
105DNA strand elongation (GO:0022616)3.38505498
106mitotic spindle checkpoint (GO:0071174)3.38064027
107regulation of reproductive process (GO:2000241)3.36984632
108histone exchange (GO:0043486)3.36672454
109regulation of helicase activity (GO:0051095)3.36450501
110chromosome organization involved in meiosis (GO:0070192)3.34749279
111DNA methylation or demethylation (GO:0044728)3.34351143
112gene silencing (GO:0016458)3.32874027
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32716761
114IMP biosynthetic process (GO:0006188)3.32637127
115DNA replication-independent nucleosome organization (GO:0034724)3.32147426
116DNA replication-independent nucleosome assembly (GO:0006336)3.32147426
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32108996
118negative regulation of meiosis (GO:0045835)3.31612107
119regulation of female receptivity (GO:0045924)3.31537358
120regulation of cell maturation (GO:1903429)3.30600840
121cilium or flagellum-dependent cell motility (GO:0001539)3.29286836
122mitotic spindle assembly checkpoint (GO:0007094)3.28849136
123meiosis I (GO:0007127)3.28140861
124meiotic cell cycle process (GO:1903046)3.28119083
125centriole replication (GO:0007099)3.25672681
126spindle assembly checkpoint (GO:0071173)3.25614273
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25535573
128ribonucleoprotein complex biogenesis (GO:0022613)3.25011734
129transcription from RNA polymerase I promoter (GO:0006360)3.24858957
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23591646
131termination of RNA polymerase I transcription (GO:0006363)3.21756577
132male meiosis (GO:0007140)3.20458738
133histone H3-K9 demethylation (GO:0033169)3.20384503
134termination of RNA polymerase III transcription (GO:0006386)3.19125366
135transcription elongation from RNA polymerase III promoter (GO:0006385)3.19125366
136telomere maintenance via semi-conservative replication (GO:0032201)3.18753714
137regulation of sister chromatid segregation (GO:0033045)3.16288356
138regulation of mitotic sister chromatid separation (GO:0010965)3.16288356
139regulation of mitotic sister chromatid segregation (GO:0033047)3.16288356
140inner cell mass cell proliferation (GO:0001833)3.14097151
141transcription elongation from RNA polymerase I promoter (GO:0006362)3.13831362
142male meiosis I (GO:0007141)3.12577378
143microtubule depolymerization (GO:0007019)3.12451108
144protein localization to chromosome (GO:0034502)3.11604257
145DNA unwinding involved in DNA replication (GO:0006268)3.09780108
146transcription initiation from RNA polymerase I promoter (GO:0006361)3.08045184
147negative regulation of DNA-dependent DNA replication (GO:2000104)3.07680033
148spliceosomal snRNP assembly (GO:0000387)3.07506816
149DNA modification (GO:0006304)3.07479076
150positive regulation of histone methylation (GO:0031062)3.07398056
1517-methylguanosine mRNA capping (GO:0006370)3.06335827
152pore complex assembly (GO:0046931)3.06309782
153positive regulation of mitotic sister chromatid separation (GO:1901970)3.05713269
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05713269
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05713269
156glycine metabolic process (GO:0006544)3.05458538
157rRNA methylation (GO:0031167)3.04562189
158chromosome segregation (GO:0007059)3.03556713
159interkinetic nuclear migration (GO:0022027)3.01284025
160female mating behavior (GO:0060180)3.00373823
161regulation of phospholipid biosynthetic process (GO:0071071)2.99732871
162spermatid development (GO:0007286)2.96042658
163regulation of chromatin silencing (GO:0031935)2.88342408
164regulation of steroid hormone biosynthetic process (GO:0090030)2.80274724
165proteasome assembly (GO:0043248)2.79174761
166regulation of histone methylation (GO:0031060)2.78365454
167centriole assembly (GO:0098534)2.75869796
168negative regulation of gene silencing (GO:0060969)2.75123424
169translesion synthesis (GO:0019985)2.71748839
170base-excision repair, AP site formation (GO:0006285)2.70915375
171DNA synthesis involved in DNA repair (GO:0000731)2.70879671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14900164
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.33898973
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.03434699
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.94434351
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90034703
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49354000
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17802468
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15208941
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.11547692
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98758067
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90011245
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73522670
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64838332
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63258281
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57611625
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54867532
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.52250089
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46739057
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.46349682
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.42228402
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39920838
22AR_21909140_ChIP-Seq_LNCAP_Human2.38498475
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.37200525
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36979607
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36031069
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33784689
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.29693222
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.29437674
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23863129
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.22026237
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20473768
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.15801272
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12549991
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12512067
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09589021
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09589021
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09589021
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07787003
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04264099
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.00408919
41XRN2_22483619_ChIP-Seq_HELA_Human2.00293496
42EZH2_22144423_ChIP-Seq_EOC_Human12.7627321
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97370980
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.94631586
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91512854
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90466166
47VDR_23849224_ChIP-Seq_CD4+_Human1.82846957
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81733634
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81511804
50ZNF274_21170338_ChIP-Seq_K562_Hela1.73407488
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73303612
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63432905
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.63042091
54DCP1A_22483619_ChIP-Seq_HELA_Human1.60577995
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59767620
56GABP_19822575_ChIP-Seq_HepG2_Human1.57745827
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56629695
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56389152
59FOXP3_21729870_ChIP-Seq_TREG_Human1.52835782
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50685986
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48330739
62KDM5A_27292631_Chip-Seq_BREAST_Human1.40646128
63TP53_22573176_ChIP-Seq_HFKS_Human1.37484958
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36088366
65TTF2_22483619_ChIP-Seq_HELA_Human1.35843678
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35567279
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35119014
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32343794
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31516638
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31507363
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.31307842
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28601608
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28546803
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25684232
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25285106
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.24925064
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24724461
78IGF1R_20145208_ChIP-Seq_DFB_Human1.21257050
79NANOG_20526341_ChIP-Seq_ESCs_Human1.21008459
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20537776
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.20008469
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18434197
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17981005
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17684115
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17345485
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15776184
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.15527595
88BCAT_22108803_ChIP-Seq_LS180_Human1.15508485
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.15443512
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.15222888
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15015767
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13631729
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13259063
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.13162556
95SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13079980
96GBX2_23144817_ChIP-Seq_PC3_Human1.12839923
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10849233
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09745985
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07756054
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07127116
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.05731725
102CIITA_25753668_ChIP-Seq_RAJI_Human1.05193028
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04326544
104SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04276631
105KAP1_27257070_Chip-Seq_ESCs_Mouse1.02156938
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.01332342
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01115082
108TCF4_23295773_ChIP-Seq_U87_Human1.01001771
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00891845
110AR_20517297_ChIP-Seq_VCAP_Human1.00576912
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99701556
112NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99684498
113ELK1_19687146_ChIP-ChIP_HELA_Human0.99601452
114RNF2_27304074_Chip-Seq_NSC_Mouse0.98750585
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98107482
116BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.97973704
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97964794
118POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96760027
119RUNX2_22187159_ChIP-Seq_PCA_Human0.96539175
120ERG_20517297_ChIP-Seq_VCAP_Human0.96189522
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96063833
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95190351
123CBP_20019798_ChIP-Seq_JUKART_Human0.95190351
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95046225
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94765074
126TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94456300
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93565372
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.93480290
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93191855
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.93143562
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93143562
132NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92223987
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.92133228
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92103774
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91245273
136TFEB_21752829_ChIP-Seq_HELA_Human0.91108310
137MYC_18940864_ChIP-ChIP_HL60_Human0.90442977
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90269633
139AR_25329375_ChIP-Seq_VCAP_Human0.89879440
140NCOR_22424771_ChIP-Seq_293T_Human0.89807868
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89693612
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89622658
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89481905
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86325624
145GATA3_26560356_Chip-Seq_TH1_Human0.86149286
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85591247
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85243163
148ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84596304
149HOXB7_26014856_ChIP-Seq_BT474_Human0.83930432
150HTT_18923047_ChIP-ChIP_STHdh_Human0.83801597
151OCT4_19829295_ChIP-Seq_ESCs_Human0.83364405
152SOX2_21211035_ChIP-Seq_LN229_Human0.83210255
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83061716
154NANOG_19829295_ChIP-Seq_ESCs_Human0.82345733
155SOX2_19829295_ChIP-Seq_ESCs_Human0.82345733
156CTCF_20526341_ChIP-Seq_ESCs_Human0.80511130
157NANOG_16518401_ChIP-PET_MESCs_Mouse0.80451570
158CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78014623
159FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77965827
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77003175
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75878331
162SMAD4_21799915_ChIP-Seq_A2780_Human0.75828677
163P300_27268052_Chip-Seq_Bcells_Human0.75595841
164GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75479539
165STAT3_23295773_ChIP-Seq_U87_Human0.75066490
166FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.74901639
167ERA_21632823_ChIP-Seq_H3396_Human0.74735136
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74394480
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73457152
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73457152
171PHF8_20622854_ChIP-Seq_HELA_Human0.71238392
172KLF4_19829295_ChIP-Seq_ESCs_Human0.71208148
173OCT4_20526341_ChIP-Seq_ESCs_Human0.70924501
174MYC_19829295_ChIP-Seq_ESCs_Human0.69539674
175E2F1_17053090_ChIP-ChIP_MCF-7_Human0.69111924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30954650
2MP0003111_abnormal_nucleus_morphology4.79927313
3MP0008057_abnormal_DNA_replication4.74247681
4MP0010094_abnormal_chromosome_stability4.61515353
5MP0004957_abnormal_blastocyst_morpholog4.18576462
6MP0008877_abnormal_DNA_methylation4.07606803
7MP0003077_abnormal_cell_cycle3.77078626
8MP0008058_abnormal_DNA_repair3.72949819
9MP0003718_maternal_effect3.21841375
10MP0003123_paternal_imprinting2.78094423
11MP0003786_premature_aging2.62845884
12MP0003806_abnormal_nucleotide_metabolis2.60557127
13MP0008789_abnormal_olfactory_epithelium2.51170402
14MP0008004_abnormal_stomach_pH2.48408327
15MP0001730_embryonic_growth_arrest2.45529208
16MP0010368_abnormal_lymphatic_system2.39177864
17MP0008007_abnormal_cellular_replicative2.38471985
18MP0002210_abnormal_sex_determination2.35768614
19MP0008932_abnormal_embryonic_tissue2.34709102
20MP0000350_abnormal_cell_proliferation2.08987499
21MP0008995_early_reproductive_senescence1.99285936
22MP0005394_taste/olfaction_phenotype1.98540714
23MP0005499_abnormal_olfactory_system1.98540714
24MP0001145_abnormal_male_reproductive1.96478601
25MP0001929_abnormal_gametogenesis1.96194618
26MP0010307_abnormal_tumor_latency1.86488440
27MP0005380_embryogenesis_phenotype1.84591210
28MP0001672_abnormal_embryogenesis/_devel1.84591210
29MP0005670_abnormal_white_adipose1.83769148
30MP0000653_abnormal_sex_gland1.77112625
31MP0003950_abnormal_plasma_membrane1.73185291
32MP0002653_abnormal_ependyma_morphology1.65883209
33MP0003941_abnormal_skin_development1.65819313
34MP0002138_abnormal_hepatobiliary_system1.58008865
35MP0001697_abnormal_embryo_size1.57040046
36MP0002085_abnormal_embryonic_tissue1.55043055
37MP0003136_yellow_coat_color1.51564953
38MP0003984_embryonic_growth_retardation1.49392207
39MP0003890_abnormal_embryonic-extraembry1.47453991
40MP0002088_abnormal_embryonic_growth/wei1.44669861
41MP0002080_prenatal_lethality1.44285833
42MP0002084_abnormal_developmental_patter1.41064728
43MP0005360_urolithiasis1.39941538
44MP0003698_abnormal_male_reproductive1.38917963
45MP0005451_abnormal_body_composition1.37290050
46MP0002102_abnormal_ear_morphology1.35042325
47MP0005551_abnormal_eye_electrophysiolog1.34829917
48MP0001119_abnormal_female_reproductive1.31933604
49MP0005174_abnormal_tail_pigmentation1.30967984
50MP0003121_genomic_imprinting1.30853205
51MP0002086_abnormal_extraembryonic_tissu1.30314417
52MP0005395_other_phenotype1.28792122
53MP0004197_abnormal_fetal_growth/weight/1.28756891
54MP0006292_abnormal_olfactory_placode1.28110557
55MP0001986_abnormal_taste_sensitivity1.27551179
56MP0001984_abnormal_olfaction1.26834551
57MP0000015_abnormal_ear_pigmentation1.22750433
58MP0008260_abnormal_autophagy1.20525434
59MP0003315_abnormal_perineum_morphology1.20081163
60MP0000566_synostosis1.19764755
61MP0003879_abnormal_hair_cell1.19550115
62MP0010352_gastrointestinal_tract_polyps1.17552840
63MP0000427_abnormal_hair_cycle1.17058260
64MP0001661_extended_life_span1.16911590
65MP0003699_abnormal_female_reproductive1.12328076
66MP0000383_abnormal_hair_follicle1.09706842
67MP0002161_abnormal_fertility/fecundity1.09171131
68MP0000313_abnormal_cell_death1.08913582
69MP0003646_muscle_fatigue1.07760293
70MP0002160_abnormal_reproductive_system1.07582510
71MP0004381_abnormal_hair_follicle1.06435659
72MP0004133_heterotaxia1.05539003
73MP0005076_abnormal_cell_differentiation1.05490421
74MP0005389_reproductive_system_phenotype1.04169721
75MP0002796_impaired_skin_barrier1.00840436
76MP0003119_abnormal_digestive_system1.00293327
77MP0002019_abnormal_tumor_incidence1.00056310
78MP0000750_abnormal_muscle_regeneration0.98984469
79MP0005075_abnormal_melanosome_morpholog0.98713245
80MP0005666_abnormal_adipose_tissue0.97990809
81MP0002396_abnormal_hematopoietic_system0.97064152
82MP0010678_abnormal_skin_adnexa0.96716563
83MP0009672_abnormal_birth_weight0.94699938
84MP0003183_abnormal_peptide_metabolism0.94467579
85MP0009379_abnormal_foot_pigmentation0.94354574
86MP0003186_abnormal_redox_activity0.93452056
87MP0001502_abnormal_circadian_rhythm0.92669260
88MP0004043_abnormal_pH_regulation0.92343413
89MP0004185_abnormal_adipocyte_glucose0.88803358
90MP0002095_abnormal_skin_pigmentation0.85737484
91MP0005377_hearing/vestibular/ear_phenot0.85319042
92MP0003878_abnormal_ear_physiology0.85319042
93MP0000631_abnormal_neuroendocrine_gland0.83002935
94MP0003221_abnormal_cardiomyocyte_apopto0.82677013
95MP0001919_abnormal_reproductive_system0.82622953
96MP0009697_abnormal_copulation0.82291718
97MP0000013_abnormal_adipose_tissue0.81805089
98MP0005646_abnormal_pituitary_gland0.81494030
99MP0001324_abnormal_eye_pigmentation0.80892642
100MP0003567_abnormal_fetal_cardiomyocyte0.79906829
101MP0003936_abnormal_reproductive_system0.79764219
102MP0000678_abnormal_parathyroid_gland0.79601146
103MP0002735_abnormal_chemical_nociception0.79115194
104MP0001293_anophthalmia0.78279456
105MP0001666_abnormal_nutrient_absorption0.77442850
106MP0005266_abnormal_metabolism0.77066411
107MP0005621_abnormal_cell_physiology0.76522444
108MP0009703_decreased_birth_body0.76180628
109MP0003937_abnormal_limbs/digits/tail_de0.76023801
110MP0005384_cellular_phenotype0.75800367
111MP0001664_abnormal_digestion0.73638129
112MP0002272_abnormal_nervous_system0.71917558
113MP0002139_abnormal_hepatobiliary_system0.71860941
114MP0006036_abnormal_mitochondrial_physio0.71533820
115MP0002234_abnormal_pharynx_morphology0.70443977
116MP0002098_abnormal_vibrissa_morphology0.70195665
117MP0000762_abnormal_tongue_morphology0.68441648
118MP0005410_abnormal_fertilization0.67914881
119MP0000003_abnormal_adipose_tissue0.67914118
120MP0000358_abnormal_cell_content/0.66930401
121MP0005365_abnormal_bile_salt0.66820985
122MP0002111_abnormal_tail_morphology0.66145979
123MP0001764_abnormal_homeostasis0.65723707
124MP0002163_abnormal_gland_morphology0.64324000
125MP0003943_abnormal_hepatobiliary_system0.64287639
126MP0005647_abnormal_sex_gland0.63904455
127MP0000490_abnormal_crypts_of0.63158758
128MP0010030_abnormal_orbit_morphology0.62169704
129MP0005085_abnormal_gallbladder_physiolo0.61913213
130MP0006035_abnormal_mitochondrial_morpho0.58819030
131MP0001286_abnormal_eye_development0.57514917
132MP0005332_abnormal_amino_acid0.56752597
133MP0004142_abnormal_muscle_tone0.56088863
134MP0005645_abnormal_hypothalamus_physiol0.54448162
135MP0000465_gastrointestinal_hemorrhage0.53994968
136MP0000377_abnormal_hair_follicle0.53840936
137MP0004019_abnormal_vitamin_homeostasis0.52869328
138MP0005397_hematopoietic_system_phenotyp0.52446835
139MP0001545_abnormal_hematopoietic_system0.52446835
140MP0002233_abnormal_nose_morphology0.52182442
141MP0000470_abnormal_stomach_morphology0.52151772
142MP0002269_muscular_atrophy0.51476955
143MP0001849_ear_inflammation0.51247026
144MP0009840_abnormal_foam_cell0.50596929
145MP0009053_abnormal_anal_canal0.48889793
146MP0001968_abnormal_touch/_nociception0.48670254
147MP0002089_abnormal_postnatal_growth/wei0.48503890
148MP0005501_abnormal_skin_physiology0.48003331
149MP0000432_abnormal_head_morphology0.47216877
150MP0005409_darkened_coat_color0.45065031

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.99405218
2Anterior segment dysgenesis (HP:0007700)5.37937099
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.31837694
4Hypoplasia of the fovea (HP:0007750)5.31837694
5Abnormality of the fovea (HP:0000493)5.13681776
6Breast hypoplasia (HP:0003187)5.07095562
7Male infertility (HP:0003251)4.67051856
8Abnormality of the labia minora (HP:0012880)4.49934144
9Gonadotropin excess (HP:0000837)4.39845590
10Impulsivity (HP:0100710)4.38480127
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30003137
12Infertility (HP:0000789)4.24354028
13Chromsome breakage (HP:0040012)4.23461680
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.21982523
15Absent/shortened dynein arms (HP:0200106)4.21982523
16Carpal bone hypoplasia (HP:0001498)4.20325120
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.14040895
18Lip pit (HP:0100267)3.92398443
19Oligodactyly (hands) (HP:0001180)3.91274574
20Ependymoma (HP:0002888)3.86089248
21Abnormal ciliary motility (HP:0012262)3.84441494
22Hyperglycinemia (HP:0002154)3.75313329
23Patellar aplasia (HP:0006443)3.72530043
24Osteomalacia (HP:0002749)3.71993307
25Tubulointerstitial nephritis (HP:0001970)3.70193989
26Absent radius (HP:0003974)3.65995197
27Oligodactyly (HP:0012165)3.56324025
28Hyperglycinuria (HP:0003108)3.46759825
29Aplasia/Hypoplasia of the patella (HP:0006498)3.46155361
30Aplasia involving forearm bones (HP:0009822)3.40150744
31Absent forearm bone (HP:0003953)3.40150744
32Aplasia/Hypoplasia of the macula (HP:0008059)3.36031939
33Hypergonadotropic hypogonadism (HP:0000815)3.35569906
34Abnormal respiratory motile cilium physiology (HP:0012261)3.31918724
35Meckel diverticulum (HP:0002245)3.30227131
36Abnormal spermatogenesis (HP:0008669)3.24951531
37Oral leukoplakia (HP:0002745)3.23397553
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.21454928
39Supernumerary spleens (HP:0009799)3.17430848
40Abnormality of chromosome stability (HP:0003220)3.17154420
41Abnormality of the preputium (HP:0100587)3.15298821
42Azoospermia (HP:0000027)3.15287137
43Cerebral hypomyelination (HP:0006808)3.15231808
44Aplasia/Hypoplasia affecting the retina (HP:0008061)3.11715809
45Abnormality of the ileum (HP:0001549)3.11582727
46Selective tooth agenesis (HP:0001592)3.07639849
47Abnormal respiratory epithelium morphology (HP:0012253)3.01470697
48Abnormal respiratory motile cilium morphology (HP:0005938)3.01470697
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.95224432
50Premature ovarian failure (HP:0008209)2.90394697
51Rough bone trabeculation (HP:0100670)2.87691102
52Abnormality of serine family amino acid metabolism (HP:0010894)2.76809931
53Abnormality of glycine metabolism (HP:0010895)2.76809931
54Medulloblastoma (HP:0002885)2.75986292
55Hypophosphatemic rickets (HP:0004912)2.75654399
56Astrocytoma (HP:0009592)2.75081781
57Abnormality of the astrocytes (HP:0100707)2.75081781
58Rhinitis (HP:0012384)2.73906203
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72002395
60Facial hemangioma (HP:0000329)2.71842681
61Rhabdomyosarcoma (HP:0002859)2.68586005
62Absent thumb (HP:0009777)2.67597246
63Secondary amenorrhea (HP:0000869)2.66825935
64Abnormality of pyrimidine metabolism (HP:0004353)2.65675834
65Aplasia/hypoplasia of the humerus (HP:0006507)2.58409974
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.53935665
67Shawl scrotum (HP:0000049)2.51085484
68Degeneration of anterior horn cells (HP:0002398)2.50987676
69Abnormality of the anterior horn cell (HP:0006802)2.50987676
70Cone-rod dystrophy (HP:0000548)2.49099241
71Abnormality of the lower motor neuron (HP:0002366)2.48222309
72Ureteral duplication (HP:0000073)2.47339758
73Duodenal stenosis (HP:0100867)2.45771057
74Small intestinal stenosis (HP:0012848)2.45771057
75Papillary thyroid carcinoma (HP:0002895)2.44600690
76Glioma (HP:0009733)2.43984438
77Malnutrition (HP:0004395)2.43392815
78Horseshoe kidney (HP:0000085)2.41812016
79Abnormal biliary tract physiology (HP:0012439)2.41491625
80Bile duct proliferation (HP:0001408)2.41491625
81Loss of speech (HP:0002371)2.40250236
82Breast aplasia (HP:0100783)2.39004304
83Abdominal situs inversus (HP:0003363)2.36187671
84Abnormality of abdominal situs (HP:0011620)2.36187671
85Agnosia (HP:0010524)2.35307872
86Metaphyseal irregularity (HP:0003025)2.34805572
87Bone marrow hypocellularity (HP:0005528)2.32769936
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.29769959
89Median cleft lip (HP:0000161)2.28929197
90Colon cancer (HP:0003003)2.28702623
91Generalized hypopigmentation of hair (HP:0011358)2.28590694
92Absent hand (HP:0004050)2.28276560
93Spinal muscular atrophy (HP:0007269)2.25169295
94Duplicated collecting system (HP:0000081)2.23683291
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23533611
96Aplasia/Hypoplasia of the breasts (HP:0010311)2.20681174
97Multiple enchondromatosis (HP:0005701)2.17997151
98Sparse eyelashes (HP:0000653)2.17970894
99CNS hypomyelination (HP:0003429)2.15713641
100Neoplasm of the pancreas (HP:0002894)2.14853102
101Neoplasm of the oral cavity (HP:0100649)2.14371679
102Bronchiectasis (HP:0002110)2.14321404
103Abnormal gallbladder physiology (HP:0012438)2.14229056
104Cholecystitis (HP:0001082)2.14229056
105Abnormal trabecular bone morphology (HP:0100671)2.13919285
106Anhidrosis (HP:0000970)2.13725978
107Pulmonary fibrosis (HP:0002206)2.12846545
108Hypoplasia of the uterus (HP:0000013)2.12301647
109Tubulointerstitial abnormality (HP:0001969)2.12058441
110Sloping forehead (HP:0000340)2.11925965
111Abnormality of serum amino acid levels (HP:0003112)2.10688804
112Short humerus (HP:0005792)2.10386149
113Facial cleft (HP:0002006)2.08612698
114Short thumb (HP:0009778)2.08017063
115Abnormality of the duodenum (HP:0002246)2.05039375
116Ectopic kidney (HP:0000086)2.04931919
117Hand muscle atrophy (HP:0009130)2.03742450
118Neoplasm of striated muscle (HP:0009728)2.02897022
119Myelodysplasia (HP:0002863)2.02559962
120Pendular nystagmus (HP:0012043)2.01243412
121Abnormality of the renal cortex (HP:0011035)2.00803626
122Biliary tract neoplasm (HP:0100574)2.00028121
123Pili torti (HP:0003777)1.99669032
124Split foot (HP:0001839)1.98680402
125Short tibia (HP:0005736)1.98150403
126Tracheoesophageal fistula (HP:0002575)1.96736787
127Decreased central vision (HP:0007663)1.95447282
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92551079
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.92312414
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92312414
131Posterior subcapsular cataract (HP:0007787)1.92069809
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.90928592
133Abnormal lung lobation (HP:0002101)1.89314632
134Cafe-au-lait spot (HP:0000957)1.88496737
135Clitoromegaly (HP:0000057)1.86784396
136Triphalangeal thumb (HP:0001199)1.86555934
137Metaphyseal cupping (HP:0003021)1.86403044
138Abnormality of the carotid arteries (HP:0005344)1.86339640
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.86171327
140Hypercortisolism (HP:0001578)1.86155407
141Premature graying of hair (HP:0002216)1.85721583
142Adrenal hypoplasia (HP:0000835)1.85041773
143Abnormal biliary tract morphology (HP:0012440)1.84837395
144Generalized aminoaciduria (HP:0002909)1.82757582
145Renal cortical cysts (HP:0000803)1.81997204
146Septo-optic dysplasia (HP:0100842)1.81527040
147Fair hair (HP:0002286)1.81372752
148Squamous cell carcinoma (HP:0002860)1.80695077
149Proximal tubulopathy (HP:0000114)1.79862250
150Abnormality of the renal collecting system (HP:0004742)1.78745974
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.78669386
152Heterotopia (HP:0002282)1.78659482
153Horizontal nystagmus (HP:0000666)1.78080125
154IgG deficiency (HP:0004315)1.76905310
155Trismus (HP:0000211)1.75698904
156Prominent nose (HP:0000448)1.75057461
157Rectovaginal fistula (HP:0000143)1.74759405
158Rectal fistula (HP:0100590)1.74759405
159Scotoma (HP:0000575)1.74672945
160Gaze-evoked nystagmus (HP:0000640)1.73888708
161Breech presentation (HP:0001623)1.73701512
162Atresia of the external auditory canal (HP:0000413)1.72929385
163Subcapsular cataract (HP:0000523)1.72467110
164Capillary hemangiomas (HP:0005306)1.71922429
165Abnormality of the labia (HP:0000058)1.70661307
166Irregular epiphyses (HP:0010582)1.70566860
167Microvesicular hepatic steatosis (HP:0001414)1.69669176
168Hyperpituitarism (HP:0010514)1.69631817
169Abnormality of the anterior chamber (HP:0000593)1.68222122
170Abnormality of the salivary glands (HP:0010286)1.66981703
171Methylmalonic aciduria (HP:0012120)1.66926158
172Severe visual impairment (HP:0001141)1.66560489
173Rickets (HP:0002748)1.65010310
174Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63861651
175Lower limb hyperreflexia (HP:0002395)1.61004212
176Posterior embryotoxon (HP:0000627)1.60822228
177Truncal obesity (HP:0001956)1.60449699
178Abnormal hair laboratory examination (HP:0003328)1.59581047
179Chronic bronchitis (HP:0004469)1.59280935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.89681452
2WEE14.77276729
3BUB14.76661636
4CDC73.65560019
5TLK13.53533569
6TTK3.01675389
7EIF2AK12.95827294
8NEK22.86156854
9MAP3K92.69782790
10STK38L2.67202917
11BRSK22.60993545
12SRPK12.59842787
13CDK122.59114107
14ACVR1B2.57673109
15CDK192.51633045
16PLK42.49871286
17TXK2.45940648
18PLK12.43973794
19ARAF2.43259215
20MET2.41609310
21NEK12.41320688
22TAOK32.35333576
23TSSK62.05193667
24EPHA22.03955283
25MST42.02218173
26MAP4K21.95325012
27PLK31.89328766
28CHEK21.87553149
29AKT31.86577562
30LATS21.82651785
31CDK71.82074198
32BRSK11.82039008
33PDK31.80829321
34PDK41.80829321
35MKNK21.72320715
36EIF2AK31.64423645
37LATS11.63879825
38VRK21.60116254
39DYRK31.52149452
40AURKB1.51013864
41ATR1.49050734
42CHEK11.43543755
43LMTK21.42808858
44PNCK1.42262624
45AURKA1.36629434
46CDK41.31189175
47PDK21.28207853
48MKNK11.27194722
49STK31.27097509
50STK161.21309125
51BMPR1B1.19023675
52MAP3K121.18413635
53PASK1.12167654
54TRIM281.03511446
55MELK1.03382317
56VRK11.00331332
57RPS6KB21.00051602
58ATM0.99756987
59STK390.99615591
60CDK20.99310414
61BRD40.97375932
62OXSR10.94561487
63ALK0.91944221
64EIF2AK20.90657876
65BRAF0.89653083
66STK40.88740849
67MAP3K80.87460675
68IRAK30.86120971
69CCNB10.84557988
70TESK20.83613465
71BCKDK0.82528897
72KSR20.80971653
73CDK10.77701132
74CSNK1G10.77656661
75WNK10.76542710
76RPS6KA40.75810569
77NME20.75743076
78STK240.74185391
79PRKCI0.74061991
80RAF10.73412411
81ZAK0.71711291
82CSNK2A20.70832864
83PINK10.69042153
84NLK0.67560589
85DAPK10.65783551
86PTK20.64929582
87MTOR0.64237833
88DYRK20.63734249
89CSNK2A10.61474538
90CASK0.58539924
91PAK10.57563361
92PBK0.56346574
93CSNK1G30.54536562
94MOS0.54293147
95TYRO30.54184618
96CSNK1E0.52054383
97CSNK1A1L0.51090208
98KDR0.50323565
99PIM10.49500940
100MAPKAPK30.47930691
101CDK80.47685400
102PAK40.47341014
103MUSK0.47165465
104ERBB40.43581064
105STK100.43538976
106CSNK1G20.42546437
107WNK30.39924292
108WNK40.39682712
109CSNK1D0.39666779
110MAP3K140.39545528
111AKT20.39259661
112NTRK30.38992690
113CDK30.38790350
114TNK20.37926170
115CDK60.37650453
116TEC0.37381139
117PRKDC0.36319509
118MAP3K60.35170916
119NTRK20.34755107
120MAPKAPK50.33986600
121KSR10.33665456
122GSK3B0.33343454
123ICK0.32987140
124PRKAA10.32599764
125EPHA40.31898740
126PRKCQ0.31753598
127IKBKE0.31336644
128MARK30.31016729
129IKBKB0.30347758
130MAPK130.30346364
131STK380.30275578
132MAPK140.29328759
133TAOK20.28912663
134NEK60.28194997
135NEK90.27699543
136MAPK110.27397175
137CSF1R0.24583457
138NUAK10.24071669
139PDK10.23731313
140TGFBR10.22022001
141MAP3K50.21789373
142ADRBK20.21625892
143CAMK1D0.21381545
144CAMK1G0.21289960
145MAPK100.21276976
146FLT30.21025593
147PHKG20.20766715
148MAPK10.19177667
149CDK90.19158358
150RPS6KB10.18896994
151ABL20.18586807
152AKT10.18340558

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.55718843
2RNA polymerase_Homo sapiens_hsa030204.01993697
3DNA replication_Homo sapiens_hsa030303.73796068
4Mismatch repair_Homo sapiens_hsa034303.59459397
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.45329139
6RNA transport_Homo sapiens_hsa030133.31027460
7Ovarian steroidogenesis_Homo sapiens_hsa049132.91436238
8Homologous recombination_Homo sapiens_hsa034402.89606384
9Vitamin B6 metabolism_Homo sapiens_hsa007502.86256933
10Spliceosome_Homo sapiens_hsa030402.71168020
11Cell cycle_Homo sapiens_hsa041102.67929172
12One carbon pool by folate_Homo sapiens_hsa006702.63711321
13Basal transcription factors_Homo sapiens_hsa030222.56295647
14Nucleotide excision repair_Homo sapiens_hsa034202.50933160
15Proteasome_Homo sapiens_hsa030502.48071686
16Pyrimidine metabolism_Homo sapiens_hsa002402.37784621
17Fanconi anemia pathway_Homo sapiens_hsa034602.35607853
18Dorso-ventral axis formation_Homo sapiens_hsa043202.32157991
19Base excision repair_Homo sapiens_hsa034102.26026687
20Caffeine metabolism_Homo sapiens_hsa002322.15440682
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14672694
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97311506
23Phototransduction_Homo sapiens_hsa047441.91360759
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76382396
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72275406
26mRNA surveillance pathway_Homo sapiens_hsa030151.69880008
27RNA degradation_Homo sapiens_hsa030181.69166961
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61713393
29Folate biosynthesis_Homo sapiens_hsa007901.60755351
30Olfactory transduction_Homo sapiens_hsa047401.59618051
31Non-homologous end-joining_Homo sapiens_hsa034501.56878377
32Biosynthesis of amino acids_Homo sapiens_hsa012301.52912455
33p53 signaling pathway_Homo sapiens_hsa041151.51237327
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45928285
35Circadian rhythm_Homo sapiens_hsa047101.45664172
36Fatty acid elongation_Homo sapiens_hsa000621.45223477
37Ribosome_Homo sapiens_hsa030101.44963563
38Purine metabolism_Homo sapiens_hsa002301.44237139
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.42119125
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33292216
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20953437
42Selenocompound metabolism_Homo sapiens_hsa004501.19481132
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.15805031
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13032230
45Oocyte meiosis_Homo sapiens_hsa041141.11842062
46Pentose phosphate pathway_Homo sapiens_hsa000301.11050402
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.11010241
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03325468
49ABC transporters_Homo sapiens_hsa020101.02338904
50Epstein-Barr virus infection_Homo sapiens_hsa051691.02141842
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96149193
52Carbon metabolism_Homo sapiens_hsa012000.91929547
53Asthma_Homo sapiens_hsa053100.91063703
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88618539
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.86606116
56Autoimmune thyroid disease_Homo sapiens_hsa053200.84444709
57Arginine and proline metabolism_Homo sapiens_hsa003300.83292934
58Arginine biosynthesis_Homo sapiens_hsa002200.80438655
59Nicotine addiction_Homo sapiens_hsa050330.75438496
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74861608
61Regulation of autophagy_Homo sapiens_hsa041400.73820999
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73723868
63Glutathione metabolism_Homo sapiens_hsa004800.71734108
64Inositol phosphate metabolism_Homo sapiens_hsa005620.69617513
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.69257782
66Allograft rejection_Homo sapiens_hsa053300.68868540
67beta-Alanine metabolism_Homo sapiens_hsa004100.67377364
68Rheumatoid arthritis_Homo sapiens_hsa053230.67288736
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67206520
70Pyruvate metabolism_Homo sapiens_hsa006200.64881592
71Vitamin digestion and absorption_Homo sapiens_hsa049770.64829096
72Fatty acid degradation_Homo sapiens_hsa000710.64591477
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64327020
74Propanoate metabolism_Homo sapiens_hsa006400.63632157
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61432600
76Gap junction_Homo sapiens_hsa045400.60578951
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59133024
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58866587
79Synaptic vesicle cycle_Homo sapiens_hsa047210.58221914
80Fatty acid biosynthesis_Homo sapiens_hsa000610.53626789
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.53282049
82Bile secretion_Homo sapiens_hsa049760.51024315
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50677024
84Sulfur relay system_Homo sapiens_hsa041220.50259212
85Lysine degradation_Homo sapiens_hsa003100.50075029
86Fructose and mannose metabolism_Homo sapiens_hsa000510.49730243
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49280163
88Linoleic acid metabolism_Homo sapiens_hsa005910.48840349
89Herpes simplex infection_Homo sapiens_hsa051680.46872694
90Glycerolipid metabolism_Homo sapiens_hsa005610.46637185
91Primary immunodeficiency_Homo sapiens_hsa053400.45968217
92TGF-beta signaling pathway_Homo sapiens_hsa043500.45522718
93Graft-versus-host disease_Homo sapiens_hsa053320.44892507
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.42806531
95GABAergic synapse_Homo sapiens_hsa047270.42788734
96Viral carcinogenesis_Homo sapiens_hsa052030.42774654
97Fatty acid metabolism_Homo sapiens_hsa012120.42409490
98Metabolic pathways_Homo sapiens_hsa011000.42263450
99Calcium signaling pathway_Homo sapiens_hsa040200.41813790
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41235489
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39808833
102Hippo signaling pathway_Homo sapiens_hsa043900.38962106
103Taste transduction_Homo sapiens_hsa047420.38284724
104Parkinsons disease_Homo sapiens_hsa050120.38235869
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36614098
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35948578
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35601448
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35223383
109Small cell lung cancer_Homo sapiens_hsa052220.33820590
110Nitrogen metabolism_Homo sapiens_hsa009100.33759077
111Tryptophan metabolism_Homo sapiens_hsa003800.33086172
112MicroRNAs in cancer_Homo sapiens_hsa052060.32836623
113Phagosome_Homo sapiens_hsa041450.32294750
114PPAR signaling pathway_Homo sapiens_hsa033200.30974194
115Retinol metabolism_Homo sapiens_hsa008300.29113873
116Thyroid cancer_Homo sapiens_hsa052160.28956937
117Influenza A_Homo sapiens_hsa051640.28487339
118Arachidonic acid metabolism_Homo sapiens_hsa005900.28287603
119Peroxisome_Homo sapiens_hsa041460.28034168
120Type I diabetes mellitus_Homo sapiens_hsa049400.27592708
121HTLV-I infection_Homo sapiens_hsa051660.27006251
122Salivary secretion_Homo sapiens_hsa049700.25924668
123Antigen processing and presentation_Homo sapiens_hsa046120.25392281
124Mineral absorption_Homo sapiens_hsa049780.25020136
125Basal cell carcinoma_Homo sapiens_hsa052170.23368201
126mTOR signaling pathway_Homo sapiens_hsa041500.23162661
127Cardiac muscle contraction_Homo sapiens_hsa042600.22944518
128Steroid biosynthesis_Homo sapiens_hsa001000.22800125
129Serotonergic synapse_Homo sapiens_hsa047260.22618357
130Morphine addiction_Homo sapiens_hsa050320.22015358
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21263270
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21217805
133Chemical carcinogenesis_Homo sapiens_hsa052040.20747657
134Hedgehog signaling pathway_Homo sapiens_hsa043400.20030221
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.17545662
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17382966
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15502909
138Histidine metabolism_Homo sapiens_hsa003400.15195150
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13887900
140Systemic lupus erythematosus_Homo sapiens_hsa053220.13280436
141Butanoate metabolism_Homo sapiens_hsa006500.12865672
142Huntingtons disease_Homo sapiens_hsa050160.12458000
143Phenylalanine metabolism_Homo sapiens_hsa003600.11718720
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11655288
145Fat digestion and absorption_Homo sapiens_hsa049750.11476907
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10889605
147Sphingolipid metabolism_Homo sapiens_hsa006000.10500804
148Collecting duct acid secretion_Homo sapiens_hsa049660.09809824
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09768883
150Endocytosis_Homo sapiens_hsa041440.08757713
151Hematopoietic cell lineage_Homo sapiens_hsa046400.06949669
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06731348

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