PMS2P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.26171981
2rRNA methylation (GO:0031167)4.91640181
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.84847490
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.84847490
5NADH dehydrogenase complex assembly (GO:0010257)4.84847490
6rRNA modification (GO:0000154)4.48112428
7platelet dense granule organization (GO:0060155)4.43316166
8behavioral response to nicotine (GO:0035095)4.29112888
9regulation of cilium movement (GO:0003352)4.27376171
10organelle disassembly (GO:1903008)4.25097605
11ribonucleoprotein complex disassembly (GO:0032988)4.13743222
12mitochondrial respiratory chain complex assembly (GO:0033108)4.12354790
13L-fucose catabolic process (GO:0042355)4.11687398
14fucose catabolic process (GO:0019317)4.11687398
15L-fucose metabolic process (GO:0042354)4.11687398
16protein complex biogenesis (GO:0070271)4.10126983
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07244409
18protein targeting to Golgi (GO:0000042)4.06317286
19establishment of protein localization to Golgi (GO:0072600)4.00220851
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.88629452
21relaxation of smooth muscle (GO:0044557)3.79766765
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.72141105
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66738369
24C4-dicarboxylate transport (GO:0015740)3.62664208
25Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58007440
26protein prenylation (GO:0018342)3.50390577
27prenylation (GO:0097354)3.50390577
28negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.48932952
29DNA deamination (GO:0045006)3.45357766
30response to pheromone (GO:0019236)3.42567185
31mature B cell differentiation (GO:0002335)3.41320125
32chaperone-mediated protein transport (GO:0072321)3.36040234
33cilium or flagellum-dependent cell motility (GO:0001539)3.35336988
34epithelial cilium movement (GO:0003351)3.35026810
35anterograde synaptic vesicle transport (GO:0048490)3.34112977
36DNA damage response, detection of DNA damage (GO:0042769)3.33834660
37positive regulation of steroid hormone secretion (GO:2000833)3.28500921
38ubiquinone biosynthetic process (GO:0006744)3.27331365
39protein localization to Golgi apparatus (GO:0034067)3.21734964
40GTP biosynthetic process (GO:0006183)3.20616858
41ribosomal small subunit assembly (GO:0000028)3.17715653
42respiratory electron transport chain (GO:0022904)3.17069070
43electron transport chain (GO:0022900)3.16341217
44pseudouridine synthesis (GO:0001522)3.10279403
45germ cell migration (GO:0008354)3.10045416
46ubiquinone metabolic process (GO:0006743)3.09646399
47anterograde axon cargo transport (GO:0008089)3.06793671
48actin nucleation (GO:0045010)3.04360701
49phenylpropanoid metabolic process (GO:0009698)3.01415219
50regulation of meiosis I (GO:0060631)3.00713413
51preassembly of GPI anchor in ER membrane (GO:0016254)2.97368266
52protein targeting to mitochondrion (GO:0006626)2.96823816
53startle response (GO:0001964)2.96359005
54central nervous system projection neuron axonogenesis (GO:0021952)2.94838447
55neural tube formation (GO:0001841)2.94357300
56nonmotile primary cilium assembly (GO:0035058)2.91932759
57sympathetic nervous system development (GO:0048485)2.91251163
58positive regulation of calcium ion import (GO:0090280)2.90150488
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89852410
60mitochondrial RNA metabolic process (GO:0000959)2.88449340
61regulation of Rac GTPase activity (GO:0032314)2.82774146
62energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82195670
63ATP synthesis coupled proton transport (GO:0015986)2.82195670
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81356590
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81356590
66establishment of protein localization to mitochondrion (GO:0072655)2.76175949
67negative regulation of norepinephrine secretion (GO:0010700)2.75759047
68aggressive behavior (GO:0002118)2.74334099
69mature B cell differentiation involved in immune response (GO:0002313)2.74220605
70regulation of microtubule-based movement (GO:0060632)2.71843668
71regulation of dopamine secretion (GO:0014059)2.70618646
72positive regulation of vasculogenesis (GO:2001214)2.69030513
73intraciliary transport (GO:0042073)2.68255888
74mismatch repair (GO:0006298)2.67093083
75RNA methylation (GO:0001510)2.66393366
76detection of light stimulus involved in sensory perception (GO:0050962)2.65735758
77detection of light stimulus involved in visual perception (GO:0050908)2.65735758
78opioid receptor signaling pathway (GO:0038003)2.65304287
79protein neddylation (GO:0045116)2.64368048
80protein sumoylation (GO:0016925)2.64121282
81quinone biosynthetic process (GO:1901663)2.62028359
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59313481
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.58349377
84termination of RNA polymerase III transcription (GO:0006386)2.58349377
85histone H2A ubiquitination (GO:0033522)2.57576314
86auditory receptor cell stereocilium organization (GO:0060088)2.56840286
87protein polyglutamylation (GO:0018095)2.56493062
88cilium movement (GO:0003341)2.56193690
89positive regulation of amino acid transport (GO:0051957)2.55946527
90mannosylation (GO:0097502)2.55716787
91synaptic transmission, cholinergic (GO:0007271)2.53928782
92CTP biosynthetic process (GO:0006241)2.50362068
93CTP metabolic process (GO:0046036)2.50362068
94UTP biosynthetic process (GO:0006228)2.50006364
95respiratory chain complex IV assembly (GO:0008535)2.49839943
96UTP metabolic process (GO:0046051)2.49625077
97protein localization to mitochondrion (GO:0070585)2.48799133
98axon cargo transport (GO:0008088)2.48504086
99short-term memory (GO:0007614)2.47015748
100regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.46128294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.45316894
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.26174240
3GBX2_23144817_ChIP-Seq_PC3_Human3.11553768
4EZH2_22144423_ChIP-Seq_EOC_Human3.09094991
5TAF15_26573619_Chip-Seq_HEK293_Human3.01370164
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97297494
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84664419
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78009109
9IGF1R_20145208_ChIP-Seq_DFB_Human2.72468630
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71971948
11EWS_26573619_Chip-Seq_HEK293_Human2.56503126
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53771289
13FUS_26573619_Chip-Seq_HEK293_Human2.48593449
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44247316
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.42426411
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32485450
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18168219
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12745100
19ELK1_19687146_ChIP-ChIP_HELA_Human2.10989481
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05753099
21ER_23166858_ChIP-Seq_MCF-7_Human2.05392031
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05238007
23VDR_23849224_ChIP-Seq_CD4+_Human1.97955114
24VDR_22108803_ChIP-Seq_LS180_Human1.95148101
25TP53_22573176_ChIP-Seq_HFKS_Human1.94472633
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90754451
27CBP_20019798_ChIP-Seq_JUKART_Human1.83041192
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83041192
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82681161
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.71991578
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71199510
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68007838
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67193782
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.63757841
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63594771
36BCAT_22108803_ChIP-Seq_LS180_Human1.61317823
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61057075
38SMAD4_21799915_ChIP-Seq_A2780_Human1.55238017
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53223485
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52105478
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.51631137
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.48668963
43P300_19829295_ChIP-Seq_ESCs_Human1.46979181
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46521679
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39204305
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37756575
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36294439
48AR_20517297_ChIP-Seq_VCAP_Human1.35945555
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35332772
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32071635
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32029046
52TCF4_22108803_ChIP-Seq_LS180_Human1.31193037
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29066246
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.28158620
55AR_25329375_ChIP-Seq_VCAP_Human1.28145574
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.26315586
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24869925
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.23997399
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23997399
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22438060
61FOXP3_21729870_ChIP-Seq_TREG_Human1.22012142
62MYC_18940864_ChIP-ChIP_HL60_Human1.21391162
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20448901
64SOX2_19829295_ChIP-Seq_ESCs_Human1.19834308
65NANOG_19829295_ChIP-Seq_ESCs_Human1.19834308
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.18805370
67RUNX2_22187159_ChIP-Seq_PCA_Human1.17558741
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16404552
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.15364820
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.13617526
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13500140
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.12931722
73TCF4_23295773_ChIP-Seq_U87_Human1.10898506
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.07420155
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.07419045
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.07048334
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06525864
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06278588
79TAF2_19829295_ChIP-Seq_ESCs_Human1.04888043
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04558882
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04544567
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04334540
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04091484
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03710014
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.03359257
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03161581
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03005287
88CDX2_22108803_ChIP-Seq_LS180_Human1.02472044
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02312129
90GABP_19822575_ChIP-Seq_HepG2_Human1.02254245
91NCOR_22424771_ChIP-Seq_293T_Human1.02216993
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02171097
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01701334
94STAT3_23295773_ChIP-Seq_U87_Human1.01113169
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00686169
96SMRT_27268052_Chip-Seq_Bcells_Human1.00589264
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00168294
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00098224
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99174380
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.98802634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.86817483
2MP0002102_abnormal_ear_morphology3.18782023
3MP0003806_abnormal_nucleotide_metabolis2.86344731
4MP0003950_abnormal_plasma_membrane2.80707613
5MP0005379_endocrine/exocrine_gland_phen2.61532784
6MP0002163_abnormal_gland_morphology2.54192825
7MP0000569_abnormal_digit_pigmentation2.49283796
8MP0004742_abnormal_vestibular_system2.36505347
9MP0002876_abnormal_thyroid_physiology2.33967645
10MP0002653_abnormal_ependyma_morphology2.32815638
11MP0000538_abnormal_urinary_bladder2.28797881
12MP0003787_abnormal_imprinting2.24224720
13MP0005551_abnormal_eye_electrophysiolog2.21701329
14MP0005645_abnormal_hypothalamus_physiol2.09432323
15MP0001529_abnormal_vocalization2.06573036
16MP0002735_abnormal_chemical_nociception1.93875643
17MP0008875_abnormal_xenobiotic_pharmacok1.80513894
18MP0005187_abnormal_penis_morphology1.75893331
19MP0005646_abnormal_pituitary_gland1.73436515
20MP0002272_abnormal_nervous_system1.70112453
21MP0002638_abnormal_pupillary_reflex1.66993362
22MP0006276_abnormal_autonomic_nervous1.64875608
23MP0004215_abnormal_myocardial_fiber1.63018557
24MP0009046_muscle_twitch1.61254444
25MP0004145_abnormal_muscle_electrophysio1.59007298
26MP0001486_abnormal_startle_reflex1.58392840
27MP0001501_abnormal_sleep_pattern1.53841441
28MP0008872_abnormal_physiological_respon1.52365953
29MP0001764_abnormal_homeostasis1.51713872
30MP0000372_irregular_coat_pigmentation1.50658966
31MP0009764_decreased_sensitivity_to1.50397477
32MP0002822_catalepsy1.50208144
33MP0008058_abnormal_DNA_repair1.49189290
34MP0002751_abnormal_autonomic_nervous1.46786562
35MP0009745_abnormal_behavioral_response1.46466972
36MP0004142_abnormal_muscle_tone1.45786426
37MP0006072_abnormal_retinal_apoptosis1.43452676
38MP0002557_abnormal_social/conspecific_i1.40515923
39MP0002009_preneoplasia1.38773009
40MP0003011_delayed_dark_adaptation1.38413185
41MP0004133_heterotaxia1.34296667
42MP0002837_dystrophic_cardiac_calcinosis1.34293796
43MP0006036_abnormal_mitochondrial_physio1.33897476
44MP0002184_abnormal_innervation1.30339246
45MP0003646_muscle_fatigue1.29700410
46MP0005410_abnormal_fertilization1.28831035
47MP0005310_abnormal_salivary_gland1.25232254
48MP0005253_abnormal_eye_physiology1.24462203
49MP0003315_abnormal_perineum_morphology1.23935728
50MP0001348_abnormal_lacrimal_gland1.23270035
51MP0001970_abnormal_pain_threshold1.23122038
52MP0003186_abnormal_redox_activity1.18840608
53MP0004924_abnormal_behavior1.18560779
54MP0005386_behavior/neurological_phenoty1.18560779
55MP0000955_abnormal_spinal_cord1.16980589
56MP0002938_white_spotting1.16736955
57MP0001664_abnormal_digestion1.14859195
58MP0002572_abnormal_emotion/affect_behav1.12831094
59MP0003718_maternal_effect1.12698327
60MP0005670_abnormal_white_adipose1.12103724
61MP0009697_abnormal_copulation1.12085212
62MP0005085_abnormal_gallbladder_physiolo1.11878557
63MP0004043_abnormal_pH_regulation1.11254201
64MP0009278_abnormal_bone_marrow1.08536838
65MP0003252_abnormal_bile_duct1.06488683
66MP0002067_abnormal_sensory_capabilities1.00268066
67MP0003121_genomic_imprinting0.98729642
68MP0002752_abnormal_somatic_nervous0.98454384
69MP0005389_reproductive_system_phenotype0.93939141
70MP0001919_abnormal_reproductive_system0.93244280
71MP0002733_abnormal_thermal_nociception0.88097830
72MP0004084_abnormal_cardiac_muscle0.87746870
73MP0005636_abnormal_mineral_homeostasis0.84896092
74MP0005647_abnormal_sex_gland0.84468538
75MP0009765_abnormal_xenobiotic_induced0.83882408
76MP0006035_abnormal_mitochondrial_morpho0.83695180
77MP0002736_abnormal_nociception_after0.81768835
78MP0003635_abnormal_synaptic_transmissio0.81322602
79MP0005332_abnormal_amino_acid0.80688669
80MP0001765_abnormal_ion_homeostasis0.77589133
81MP0008775_abnormal_heart_ventricle0.76738044
82MP0005195_abnormal_posterior_eye0.76046769
83MP0005266_abnormal_metabolism0.75704373
84MP0003880_abnormal_central_pattern0.75639430
85MP0005535_abnormal_body_temperature0.75547823
86MP0000647_abnormal_sebaceous_gland0.73788754
87MP0002064_seizures0.73037110
88MP0003633_abnormal_nervous_system0.72957977
89MP0003137_abnormal_impulse_conducting0.70100846
90MP0002160_abnormal_reproductive_system0.69479986
91MP0003693_abnormal_embryo_hatching0.68425309
92MP0002063_abnormal_learning/memory/cond0.68322065
93MP0003698_abnormal_male_reproductive0.67427508
94MP0002928_abnormal_bile_duct0.67236158
95MP0001905_abnormal_dopamine_level0.67006977
96MP0002229_neurodegeneration0.64013555
97MP0000631_abnormal_neuroendocrine_gland0.63178502
98MP0001984_abnormal_olfaction0.63020424
99MP0001929_abnormal_gametogenesis0.62796312
100MP0002069_abnormal_eating/drinking_beha0.62704278

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.59905754
2Acute necrotizing encephalopathy (HP:0006965)4.44688041
3Abnormal mitochondria in muscle tissue (HP:0008316)4.11054168
4Acute encephalopathy (HP:0006846)4.09143408
5Pancreatic cysts (HP:0001737)4.05571630
63-Methylglutaconic aciduria (HP:0003535)3.86006012
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74703709
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74703709
9Progressive macrocephaly (HP:0004481)3.64831804
10True hermaphroditism (HP:0010459)3.61553440
11Tubulointerstitial nephritis (HP:0001970)3.57257050
12Cerebral edema (HP:0002181)3.41562021
13Mitochondrial inheritance (HP:0001427)3.26541501
14Elevated erythrocyte sedimentation rate (HP:0003565)3.26371298
15Absent/shortened dynein arms (HP:0200106)3.22667528
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.22667528
17Renal cortical cysts (HP:0000803)3.04161494
18Ulnar claw (HP:0001178)3.03702505
19Increased CSF lactate (HP:0002490)2.90229211
20Volvulus (HP:0002580)2.87066410
21Constricted visual fields (HP:0001133)2.77287271
22Anencephaly (HP:0002323)2.73403278
23Abnormality of the renal collecting system (HP:0004742)2.71222314
24Medial flaring of the eyebrow (HP:0010747)2.63250724
25Hypoplasia of the pons (HP:0012110)2.58244405
26Duplicated collecting system (HP:0000081)2.54369368
27Abnormality of the pons (HP:0007361)2.54175362
28Cystic liver disease (HP:0006706)2.52725743
29Polyphagia (HP:0002591)2.52097123
30Molar tooth sign on MRI (HP:0002419)2.51274341
31Abnormality of midbrain morphology (HP:0002418)2.51274341
32Abnormality of the renal cortex (HP:0011035)2.46979923
33Amniotic constriction ring (HP:0009775)2.42219512
34Abnormality of placental membranes (HP:0011409)2.42219512
35Optic disc pallor (HP:0000543)2.40993214
36Nephrogenic diabetes insipidus (HP:0009806)2.40279895
37Type I transferrin isoform profile (HP:0003642)2.38885206
38Hepatocellular necrosis (HP:0001404)2.38392921
39Hepatic necrosis (HP:0002605)2.35660313
40Nephronophthisis (HP:0000090)2.32985190
41Congenital hepatic fibrosis (HP:0002612)2.29581004
42Increased serum lactate (HP:0002151)2.27767953
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.27189265
44Gait imbalance (HP:0002141)2.23993879
45Optic neuritis (HP:0100653)2.23051101
46Retrobulbar optic neuritis (HP:0100654)2.23051101
47Chronic bronchitis (HP:0004469)2.20645791
48Abnormality of the renal medulla (HP:0100957)2.18002860
49Acute lymphatic leukemia (HP:0006721)2.16899486
50Abnormality of lateral ventricle (HP:0030047)2.16532226
51Postaxial foot polydactyly (HP:0001830)2.16114801
52Abnormal ciliary motility (HP:0012262)2.14548270
53Congenital primary aphakia (HP:0007707)2.13994620
54Male pseudohermaphroditism (HP:0000037)2.13875296
55Abnormal respiratory epithelium morphology (HP:0012253)2.13083640
56Abnormal respiratory motile cilium morphology (HP:0005938)2.13083640
57Long foot (HP:0001833)2.13058335
58Occipital encephalocele (HP:0002085)2.10057333
59Abnormality of the anterior horn cell (HP:0006802)2.09169080
60Degeneration of anterior horn cells (HP:0002398)2.09169080
61Genital tract atresia (HP:0001827)2.06616793
62Lactic acidosis (HP:0003128)2.06488009
63Febrile seizures (HP:0002373)2.06199542
64Microvesicular hepatic steatosis (HP:0001414)2.05491410
65Increased serum pyruvate (HP:0003542)2.03919680
66Abnormal protein glycosylation (HP:0012346)2.01917589
67Abnormal glycosylation (HP:0012345)2.01917589
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01917589
69Abnormal protein N-linked glycosylation (HP:0012347)2.01917589
70Renal Fanconi syndrome (HP:0001994)2.01912900
71Adactyly (HP:0009776)2.00063418
72Type 2 muscle fiber atrophy (HP:0003554)1.98420965
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97706859
74Aplastic anemia (HP:0001915)1.95904002
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91525377
76Lethargy (HP:0001254)1.89258885
77Bile duct proliferation (HP:0001408)1.89057508
78Abnormal biliary tract physiology (HP:0012439)1.89057508
79Respiratory failure (HP:0002878)1.86201127
80Metaphyseal dysplasia (HP:0100255)1.84318190
81Leukodystrophy (HP:0002415)1.83368771
82Hyperalaninemia (HP:0003348)1.83180509
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83180509
84Abnormality of alanine metabolism (HP:0010916)1.83180509
85Vaginal atresia (HP:0000148)1.81323394
86Hyperglycinuria (HP:0003108)1.80872217
87Segmental peripheral demyelination/remyelination (HP:0003481)1.78925427
88Opisthotonus (HP:0002179)1.77393718
89Pulmonary artery stenosis (HP:0004415)1.75873182
90Proximal tubulopathy (HP:0000114)1.74967571
91Severe visual impairment (HP:0001141)1.73466239
92Poor coordination (HP:0002370)1.72857187
93Sclerocornea (HP:0000647)1.72739568
94Exercise intolerance (HP:0003546)1.71896321
95Abnormal respiratory motile cilium physiology (HP:0012261)1.71236533
96Epidermoid cyst (HP:0200040)1.69904183
97Reticulocytopenia (HP:0001896)1.68937792
98Abnormality of renal resorption (HP:0011038)1.68719251
99Abnormal number of erythroid precursors (HP:0012131)1.68358428
100Orchitis (HP:0100796)1.66726971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.76690630
2TAOK34.28010018
3NUAK12.74965157
4WNK42.74307665
5MAP3K122.65673952
6MST42.61857275
7WNK32.55875861
8TXK2.41524601
9MAP4K22.33314833
10MAPK132.30339378
11PINK12.01540242
12BCR1.97029145
13EIF2AK31.87371060
14BCKDK1.80403636
15ADRBK21.80319165
16STK391.69795457
17GRK71.66707560
18SRPK11.63355098
19TNIK1.60097225
20NEK21.54397880
21EIF2AK11.54352387
22OXSR11.54102046
23EPHA41.41859086
24DYRK21.33393755
25EPHB11.32778456
26MAP2K71.21879088
27TRIM281.17458165
28TAOK11.14427196
29MARK11.10644020
30FRK1.10481086
31MAP3K41.09000690
32MINK11.07935694
33MST1R1.05531011
34PAK31.05039104
35PBK1.01545452
36PLK41.01532453
37MKNK20.91171905
38EPHA30.90917966
39PDK20.89988595
40TLK10.87158745
41TGFBR20.84736326
42IRAK10.84640445
43LMTK20.83377969
44ROCK20.77742168
45ERBB30.77076099
46CASK0.74493784
47PIM20.72011017
48ZAK0.71732041
49GRK10.70170726
50INSRR0.67376315
51TEC0.66090674
52MYLK0.63781291
53MAPK150.62458729
54BLK0.57723355
55DAPK10.55945872
56MET0.55358507
57PHKG20.55093377
58PHKG10.55093377
59CAMK2A0.54167430
60PKN10.51842863
61PRKCE0.51519846
62MAPK40.51224673
63BUB10.51119094
64DYRK30.50979492
65ADRBK10.49866588
66MKNK10.49121114
67PRKG20.48964352
68PRKG10.47568467
69CAMKK20.47460060
70MUSK0.47174863
71AKT20.46890082
72CSNK1E0.46297930
73CSNK2A20.45930519
74TIE10.45703781
75TBK10.44820511
76CSNK1A10.44603530
77WNK10.44110183
78TYK20.43456999
79CDK30.42331153
80KIT0.42306288
81ILK0.42204300
82PRKACA0.41849941
83PRKCG0.41783274
84PRKCD0.41523711
85BRD40.40981114
86CSNK1G20.40728186
87BMPR1B0.40696442
88CSNK1G30.39734202
89PIK3CG0.38907582
90PRKACB0.38808402
91DMPK0.37471037
92RPS6KA40.37238262
93IRAK30.31696827
94STK30.31409310
95ACVR1B0.29658955
96VRK10.28912923
97NME20.28461487
98CAMK2B0.28043854
99TGFBR10.27998012
100TSSK60.27853357

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.65436648
2Parkinsons disease_Homo sapiens_hsa050123.20046364
3Basal transcription factors_Homo sapiens_hsa030222.61187859
4Ribosome_Homo sapiens_hsa030102.60791596
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.58668284
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55311895
7Protein export_Homo sapiens_hsa030602.55157555
8Huntingtons disease_Homo sapiens_hsa050162.52140953
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46938841
10Alzheimers disease_Homo sapiens_hsa050102.37095652
11Sulfur relay system_Homo sapiens_hsa041222.26323791
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15683867
13RNA polymerase_Homo sapiens_hsa030202.00342760
14Steroid biosynthesis_Homo sapiens_hsa001001.97528833
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.87506061
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86423012
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83862888
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82352187
19Fanconi anemia pathway_Homo sapiens_hsa034601.73206111
20Selenocompound metabolism_Homo sapiens_hsa004501.71903709
21Non-homologous end-joining_Homo sapiens_hsa034501.66761237
22Phototransduction_Homo sapiens_hsa047441.64749350
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62445867
24Linoleic acid metabolism_Homo sapiens_hsa005911.58658291
25Taste transduction_Homo sapiens_hsa047421.53835881
26Propanoate metabolism_Homo sapiens_hsa006401.53547974
27Proteasome_Homo sapiens_hsa030501.42516638
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38301340
29One carbon pool by folate_Homo sapiens_hsa006701.35858029
30Nitrogen metabolism_Homo sapiens_hsa009101.35226607
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35185658
32Olfactory transduction_Homo sapiens_hsa047401.34030766
33Sulfur metabolism_Homo sapiens_hsa009201.28868476
34Homologous recombination_Homo sapiens_hsa034401.26650647
35Butanoate metabolism_Homo sapiens_hsa006501.25996738
36Cardiac muscle contraction_Homo sapiens_hsa042601.25748628
37Ether lipid metabolism_Homo sapiens_hsa005651.25578387
38RNA degradation_Homo sapiens_hsa030181.21048340
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.19961621
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14926352
41RNA transport_Homo sapiens_hsa030131.14921482
42Pyrimidine metabolism_Homo sapiens_hsa002401.12609285
43Base excision repair_Homo sapiens_hsa034101.12256343
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05508488
45Asthma_Homo sapiens_hsa053101.05099017
46Glutathione metabolism_Homo sapiens_hsa004801.04726665
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00814862
48Nicotine addiction_Homo sapiens_hsa050330.99566298
49Tryptophan metabolism_Homo sapiens_hsa003800.99094287
50Allograft rejection_Homo sapiens_hsa053300.98921764
51Nucleotide excision repair_Homo sapiens_hsa034200.97086795
52Regulation of autophagy_Homo sapiens_hsa041400.97078494
53Purine metabolism_Homo sapiens_hsa002300.91654431
54Autoimmune thyroid disease_Homo sapiens_hsa053200.81140340
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80300967
56Metabolic pathways_Homo sapiens_hsa011000.78243054
57Fat digestion and absorption_Homo sapiens_hsa049750.72228480
58Arachidonic acid metabolism_Homo sapiens_hsa005900.71645353
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70911382
60Glutamatergic synapse_Homo sapiens_hsa047240.68333534
61Type I diabetes mellitus_Homo sapiens_hsa049400.67847932
62Graft-versus-host disease_Homo sapiens_hsa053320.66714273
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66188961
64Rheumatoid arthritis_Homo sapiens_hsa053230.64932230
65Retinol metabolism_Homo sapiens_hsa008300.64674666
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64410826
67Folate biosynthesis_Homo sapiens_hsa007900.63758720
68Peroxisome_Homo sapiens_hsa041460.62038557
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.61385719
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59190149
71Serotonergic synapse_Homo sapiens_hsa047260.59005611
72Salivary secretion_Homo sapiens_hsa049700.56900408
73African trypanosomiasis_Homo sapiens_hsa051430.56475764
74Circadian entrainment_Homo sapiens_hsa047130.56284393
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.56138291
76Collecting duct acid secretion_Homo sapiens_hsa049660.55345869
77Spliceosome_Homo sapiens_hsa030400.55189468
78Mismatch repair_Homo sapiens_hsa034300.54844413
79Chemical carcinogenesis_Homo sapiens_hsa052040.54504561
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53795829
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.51658039
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51205411
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50067046
84Pyruvate metabolism_Homo sapiens_hsa006200.49542538
85Oocyte meiosis_Homo sapiens_hsa041140.49497303
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.48889185
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.43854679
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41428176
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41224227
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40407411
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.39793527
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39780161
93Long-term depression_Homo sapiens_hsa047300.38332017
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37063442
95Fructose and mannose metabolism_Homo sapiens_hsa000510.36086114
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34540419
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34187486
98GABAergic synapse_Homo sapiens_hsa047270.31572164
99Renin secretion_Homo sapiens_hsa049240.30842457
100Pancreatic secretion_Homo sapiens_hsa049720.30700422

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