PMPCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.18527002
2IMP biosynthetic process (GO:0006188)5.08250580
3folic acid-containing compound biosynthetic process (GO:0009396)4.97237226
4nucleobase biosynthetic process (GO:0046112)4.69168068
5proline biosynthetic process (GO:0006561)4.62320714
6IMP metabolic process (GO:0046040)4.56352135
7purine nucleobase biosynthetic process (GO:0009113)4.46954463
8tricarboxylic acid cycle (GO:0006099)4.46484994
9regulation of mitochondrial translation (GO:0070129)4.15284121
10protein localization to kinetochore (GO:0034501)4.10577469
11DNA strand elongation involved in DNA replication (GO:0006271)4.06097015
12pseudouridine synthesis (GO:0001522)4.04323483
13DNA replication initiation (GO:0006270)3.94695313
14nuclear pore organization (GO:0006999)3.94017435
15regulation of translational termination (GO:0006449)3.90852253
16mitotic nuclear envelope disassembly (GO:0007077)3.90785420
17DNA strand elongation (GO:0022616)3.84314317
18regulation of translational fidelity (GO:0006450)3.81521468
19proteasome assembly (GO:0043248)3.75487646
20DNA replication-dependent nucleosome assembly (GO:0006335)3.72167273
21DNA replication-dependent nucleosome organization (GO:0034723)3.72167273
22formation of translation preinitiation complex (GO:0001731)3.70770844
23nuclear envelope disassembly (GO:0051081)3.67494728
24membrane disassembly (GO:0030397)3.67494728
25mitochondrial RNA metabolic process (GO:0000959)3.64609784
26maturation of 5.8S rRNA (GO:0000460)3.63317105
27mitotic G1 DNA damage checkpoint (GO:0031571)3.55550384
28tRNA methylation (GO:0030488)3.55198942
29glycine metabolic process (GO:0006544)3.54992521
30nuclear pore complex assembly (GO:0051292)3.52467450
31proline metabolic process (GO:0006560)3.48963253
32folic acid metabolic process (GO:0046655)3.46997306
33rRNA modification (GO:0000154)3.42059632
34L-serine metabolic process (GO:0006563)3.41536822
35tetrahydrofolate metabolic process (GO:0046653)3.37028614
36telomere maintenance via semi-conservative replication (GO:0032201)3.34382759
37viral mRNA export from host cell nucleus (GO:0046784)3.30979621
38lysine catabolic process (GO:0006554)3.30941483
39lysine metabolic process (GO:0006553)3.30941483
40DNA geometric change (GO:0032392)3.27275419
41DNA duplex unwinding (GO:0032508)3.26882206
42mitotic sister chromatid segregation (GO:0000070)3.25574567
43serine family amino acid biosynthetic process (GO:0009070)3.25254776
44ribonucleoprotein complex biogenesis (GO:0022613)3.25238337
45NADH metabolic process (GO:0006734)3.22972629
46protein localization to chromosome, centromeric region (GO:0071459)3.21652845
47DNA replication checkpoint (GO:0000076)3.20678633
48mitotic chromosome condensation (GO:0007076)3.20211207
49peptidyl-arginine omega-N-methylation (GO:0035247)3.19035664
50rRNA transcription (GO:0009303)3.17906353
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16579519
52maturation of SSU-rRNA (GO:0030490)3.16384169
53sister chromatid segregation (GO:0000819)3.16366213
54mitotic metaphase plate congression (GO:0007080)3.15486404
55ribosome assembly (GO:0042255)3.14249145
56rRNA processing (GO:0006364)3.12413993
57regulation of spindle organization (GO:0090224)3.12190723
58regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.11653895
59muscle filament sliding (GO:0030049)3.10795385
60actin-myosin filament sliding (GO:0033275)3.10795385
61transcription-coupled nucleotide-excision repair (GO:0006283)3.05143409
62COPI coating of Golgi vesicle (GO:0048205)3.03964372
63Golgi transport vesicle coating (GO:0048200)3.03964372
64sarcomere organization (GO:0045214)3.03057120
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02550627
66regulation of translational elongation (GO:0006448)3.01496019
67oxaloacetate metabolic process (GO:0006107)3.00782569
68negative regulation of ligase activity (GO:0051352)3.00022773
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00022773
70mitotic G1/S transition checkpoint (GO:0044819)2.99147344
71establishment of integrated proviral latency (GO:0075713)2.98555873
72chaperone-mediated protein complex assembly (GO:0051131)2.97525503
73rRNA metabolic process (GO:0016072)2.96444263
74tRNA aminoacylation for protein translation (GO:0006418)2.96352791
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96052538
76nuclear envelope organization (GO:0006998)2.93681325
77peptidyl-lysine dimethylation (GO:0018027)2.93436798
78ribosome biogenesis (GO:0042254)2.93382417
79mitotic nuclear envelope reassembly (GO:0007084)2.93271823
80nuclear envelope reassembly (GO:0031468)2.93271823
81peptidyl-histidine modification (GO:0018202)2.92814086
82transcription from mitochondrial promoter (GO:0006390)2.92222340
83pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92103342
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91942580
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91611759
86mitotic recombination (GO:0006312)2.91007388
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.90866279
88oxidative phosphorylation (GO:0006119)2.90824504
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89911828
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88779989
91telomere maintenance via recombination (GO:0000722)2.87090181
92tRNA modification (GO:0006400)2.86688057
93regulation of mitotic spindle organization (GO:0060236)2.85593159
94amino acid activation (GO:0043038)2.85543913
95tRNA aminoacylation (GO:0043039)2.85543913
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85517278
97pteridine-containing compound biosynthetic process (GO:0042559)2.84858692
98nucleobase-containing small molecule interconversion (GO:0015949)2.83925591
99metallo-sulfur cluster assembly (GO:0031163)2.83713070
100iron-sulfur cluster assembly (GO:0016226)2.83713070
101galactose catabolic process (GO:0019388)2.83379619
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83013271
103somatic hypermutation of immunoglobulin genes (GO:0016446)2.83013271
104protein deneddylation (GO:0000338)2.82855188
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82776026
106histone-serine phosphorylation (GO:0035404)2.81721599
107regulation of cellular amino acid metabolic process (GO:0006521)2.81415072
108pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.81321297
109regulation of coenzyme metabolic process (GO:0051196)2.81093319
110regulation of cofactor metabolic process (GO:0051193)2.81093319
111protein maturation by protein folding (GO:0022417)2.80836396
112pre-miRNA processing (GO:0031054)2.80351230
113regulation of posttranscriptional gene silencing (GO:0060147)2.79347339
114regulation of gene silencing by miRNA (GO:0060964)2.79347339
115regulation of gene silencing by RNA (GO:0060966)2.79347339
116negative regulation of mRNA processing (GO:0050686)2.79125668
117spliceosomal tri-snRNP complex assembly (GO:0000244)2.77978667
118metaphase plate congression (GO:0051310)2.77747978
1192-oxoglutarate metabolic process (GO:0006103)2.77249309
120base-excision repair (GO:0006284)2.77027939
121mitochondrial fusion (GO:0008053)2.76581551
122folic acid-containing compound metabolic process (GO:0006760)2.75911113
123cellular component biogenesis (GO:0044085)2.75099345
124ribosomal large subunit biogenesis (GO:0042273)2.74854732
125postreplication repair (GO:0006301)2.74214933
126tRNA metabolic process (GO:0006399)2.73818224
127amino acid salvage (GO:0043102)2.72939454
128L-methionine salvage (GO:0071267)2.72939454
129L-methionine biosynthetic process (GO:0071265)2.72939454
130signal transduction involved in DNA damage checkpoint (GO:0072422)2.72688524
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72688524
132cullin deneddylation (GO:0010388)2.72385642
133aspartate family amino acid biosynthetic process (GO:0009067)2.72262403
134UTP biosynthetic process (GO:0006228)2.70974843
135telomere maintenance via telomere lengthening (GO:0010833)2.68423746
136pentose-phosphate shunt (GO:0006098)2.66492793
137aspartate family amino acid catabolic process (GO:0009068)2.64834934
138G1 DNA damage checkpoint (GO:0044783)2.63956301
139tricarboxylic acid metabolic process (GO:0072350)2.62654692
140positive regulation of chromosome segregation (GO:0051984)2.62616575
141regulation of acyl-CoA biosynthetic process (GO:0050812)2.62438155
142histone arginine methylation (GO:0034969)2.62380046
143regulation of centrosome cycle (GO:0046605)2.60952131
144pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.60642907
145AMP metabolic process (GO:0046033)2.60538256
146glycolytic process (GO:0006096)2.58082647
147spliceosomal snRNP assembly (GO:0000387)2.57089033
148DNA conformation change (GO:0071103)2.57069917
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.57041927
150peptidyl-arginine methylation (GO:0018216)2.57041862
151peptidyl-arginine N-methylation (GO:0035246)2.57041862
152heterochromatin organization (GO:0070828)2.56668631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88913871
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07341283
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.83998553
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.78967082
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84613163
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67240544
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57313375
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53738992
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50690770
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47518077
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26532452
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.20874677
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19791679
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17506667
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16003403
16AR_21909140_ChIP-Seq_LNCAP_Human2.15334085
17XRN2_22483619_ChIP-Seq_HELA_Human2.09173412
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.99557392
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92378480
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.92134661
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89016406
22MYC_22102868_ChIP-Seq_BL_Human1.88734884
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87622906
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85788420
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.79139846
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79035712
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74515926
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73820798
29* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73101331
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72452382
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71780120
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69880595
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68948601
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67985443
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67346163
36* GABP_17652178_ChIP-ChIP_JURKAT_Human1.67300759
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66620187
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65442862
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64188039
40GABP_19822575_ChIP-Seq_HepG2_Human1.61553759
41DCP1A_22483619_ChIP-Seq_HELA_Human1.61515388
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60906921
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59459100
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58602135
45CIITA_25753668_ChIP-Seq_RAJI_Human1.57574537
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54214198
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50295236
48FOXP3_21729870_ChIP-Seq_TREG_Human1.47359156
49VDR_23849224_ChIP-Seq_CD4+_Human1.46434893
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44321950
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43513836
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43186752
53ZNF263_19887448_ChIP-Seq_K562_Human1.41941923
54KDM5A_27292631_Chip-Seq_BREAST_Human1.37967028
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35367277
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35334080
57TTF2_22483619_ChIP-Seq_HELA_Human1.32514386
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31506125
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28693891
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28334056
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27910588
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.27205525
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26607255
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25744701
65TFEB_21752829_ChIP-Seq_HELA_Human1.25643411
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.24051802
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21210919
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21028508
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20962847
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19517921
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17846802
72CLOCK_20551151_ChIP-Seq_293T_Human1.17267541
73* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16262594
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14667223
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13733928
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.12822184
77* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12765562
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.12253559
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12131124
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11059683
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10752142
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09970230
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08488419
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07374443
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06729356
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05834353
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05788977
88* P68_20966046_ChIP-Seq_HELA_Human1.04937563
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04562369
90VDR_21846776_ChIP-Seq_THP-1_Human1.04469868
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04210090
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04209544
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03970417
94ATF3_27146783_Chip-Seq_COLON_Human1.02752953
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02562469
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02459741
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00441700
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99694900
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.99442442
100LXR_22292898_ChIP-Seq_THP-1_Human0.98795491
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98327073
102ELK1_19687146_ChIP-ChIP_HELA_Human0.96474193
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96433781
104HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96260004
105GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94145211
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93996986
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93396550
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93378017
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92568968
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.91496649
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91368677
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90807718
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90789578
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90586052
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90483905
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90215201
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90134902
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.89513476
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89020173
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88993485
121RARB_24833708_ChIP-Seq_LIVER_Mouse0.88141456
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88036919
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85555484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.47319902
2MP0003705_abnormal_hypodermis_morpholog3.25903599
3MP0004084_abnormal_cardiac_muscle3.05994393
4MP0003111_abnormal_nucleus_morphology3.04057966
5MP0003693_abnormal_embryo_hatching3.00387853
6MP0004957_abnormal_blastocyst_morpholog2.94511308
7MP0010094_abnormal_chromosome_stability2.93085108
8MP0003786_premature_aging2.69464166
9MP0010352_gastrointestinal_tract_polyps2.66747518
10MP0003077_abnormal_cell_cycle2.64744243
11MP0001661_extended_life_span2.41912952
12MP0005451_abnormal_body_composition2.34255351
13MP0003646_muscle_fatigue2.32845099
14MP0000749_muscle_degeneration2.29425180
15MP0002269_muscular_atrophy2.29169427
16MP0001730_embryonic_growth_arrest2.26109878
17MP0004233_abnormal_muscle_weight2.17849664
18MP0000751_myopathy2.09978751
19MP0002837_dystrophic_cardiac_calcinosis2.08927766
20MP0003221_abnormal_cardiomyocyte_apopto2.01842461
21MP0003567_abnormal_fetal_cardiomyocyte1.95321651
22MP0003718_maternal_effect1.94186608
23MP0004087_abnormal_muscle_fiber1.93019468
24MP0003123_paternal_imprinting1.92611734
25MP0000750_abnormal_muscle_regeneration1.89712912
26MP0008007_abnormal_cellular_replicative1.85388238
27MP0005330_cardiomyopathy1.83287797
28MP0000747_muscle_weakness1.82218450
29MP0004036_abnormal_muscle_relaxation1.78620902
30MP0003984_embryonic_growth_retardation1.72414913
31MP0001672_abnormal_embryogenesis/_devel1.72296095
32MP0005380_embryogenesis_phenotype1.72296095
33MP0002088_abnormal_embryonic_growth/wei1.69937025
34MP0000350_abnormal_cell_proliferation1.68000969
35MP0004197_abnormal_fetal_growth/weight/1.67265538
36MP0001697_abnormal_embryo_size1.62907237
37MP0004130_abnormal_muscle_cell1.59274381
38MP0008932_abnormal_embryonic_tissue1.58994696
39MP0009333_abnormal_splenocyte_physiolog1.57743622
40MP0010307_abnormal_tumor_latency1.57047582
41MP0010630_abnormal_cardiac_muscle1.56253596
42MP0002080_prenatal_lethality1.55788686
43MP0004147_increased_porphyrin_level1.55155482
44MP0006036_abnormal_mitochondrial_physio1.53468434
45MP0003566_abnormal_cell_adhesion1.51735950
46MP0002106_abnormal_muscle_physiology1.49432473
47MP0005076_abnormal_cell_differentiation1.48935893
48MP0005360_urolithiasis1.47772256
49MP0005058_abnormal_lysosome_morphology1.47287190
50MP0002138_abnormal_hepatobiliary_system1.45652001
51MP0008058_abnormal_DNA_repair1.42026124
52MP0000759_abnormal_skeletal_muscle1.40038157
53MP0002086_abnormal_extraembryonic_tissu1.39046099
54MP0004215_abnormal_myocardial_fiber1.38311175
55MP0006035_abnormal_mitochondrial_morpho1.37447752
56MP0001764_abnormal_homeostasis1.34725948
57MP0002084_abnormal_developmental_patter1.33965058
58MP0002139_abnormal_hepatobiliary_system1.33508210
59MP0009697_abnormal_copulation1.30954247
60MP0008775_abnormal_heart_ventricle1.30525939
61MP0000358_abnormal_cell_content/1.29637512
62MP0008057_abnormal_DNA_replication1.28917206
63MP0009840_abnormal_foam_cell1.26584901
64MP0002085_abnormal_embryonic_tissue1.23965878
65MP0001544_abnormal_cardiovascular_syste1.23153761
66MP0005385_cardiovascular_system_phenoty1.23153761
67MP0000372_irregular_coat_pigmentation1.23068320
68MP0000678_abnormal_parathyroid_gland1.22766353
69MP0008260_abnormal_autophagy1.19453496
70MP0005266_abnormal_metabolism1.19402503
71MP0001727_abnormal_embryo_implantation1.17161143
72MP0005369_muscle_phenotype1.16905548
73MP0000733_abnormal_muscle_development1.16423578
74MP0009053_abnormal_anal_canal1.15797431
75MP0005620_abnormal_muscle_contractility1.15397252
76MP0005023_abnormal_wound_healing1.14575231
77MP0004145_abnormal_muscle_electrophysio1.14318256
78MP0002972_abnormal_cardiac_muscle1.14170817
79MP0009672_abnormal_birth_weight1.13764994
80MP0002396_abnormal_hematopoietic_system1.12375781
81MP0002160_abnormal_reproductive_system1.11883236
82MP0005075_abnormal_melanosome_morpholog1.10518430
83MP0008995_early_reproductive_senescence1.08344635
84MP0005666_abnormal_adipose_tissue1.07255284
85MP0009278_abnormal_bone_marrow1.03770301
86MP0008875_abnormal_xenobiotic_pharmacok1.02841656
87MP0006054_spinal_hemorrhage1.02764661
88MP0001873_stomach_inflammation1.01031806
89MP0006138_congestive_heart_failure1.00860436
90MP0001881_abnormal_mammary_gland0.99592489
91MP0000490_abnormal_crypts_of0.98401706
92MP0003119_abnormal_digestive_system0.98305560
93MP0000313_abnormal_cell_death0.96722250
94MP0000266_abnormal_heart_morphology0.96274060
95MP0004185_abnormal_adipocyte_glucose0.94934900
96MP0005408_hypopigmentation0.93902896
97MP0000537_abnormal_urethra_morphology0.93052282
98MP0010030_abnormal_orbit_morphology0.92537684
99MP0002653_abnormal_ependyma_morphology0.89705877
100MP0005501_abnormal_skin_physiology0.88930080
101MP0000003_abnormal_adipose_tissue0.88827204
102MP0000598_abnormal_liver_morphology0.88317050
103MP0005085_abnormal_gallbladder_physiolo0.88160505
104MP0004808_abnormal_hematopoietic_stem0.88131684
105MP0003315_abnormal_perineum_morphology0.87586251
106MP0005319_abnormal_enzyme/_coenzyme0.87265973
107MP0002019_abnormal_tumor_incidence0.86681258
108MP0003283_abnormal_digestive_organ0.86613053
109MP0003186_abnormal_redox_activity0.85840163
110MP0004858_abnormal_nervous_system0.85457676
111MP0004133_heterotaxia0.83360620
112MP0005365_abnormal_bile_salt0.80152954
113MP0002127_abnormal_cardiovascular_syste0.79727333
114MP0005332_abnormal_amino_acid0.79680593
115MP0005083_abnormal_biliary_tract0.79585491
116MP0005384_cellular_phenotype0.77977812
117MP0004264_abnormal_extraembryonic_tissu0.77518549
118MP0005220_abnormal_exocrine_pancreas0.76512409
119MP0002210_abnormal_sex_determination0.76108558
120MP0002877_abnormal_melanocyte_morpholog0.75387528
121MP0001915_intracranial_hemorrhage0.75272347
122MP0003950_abnormal_plasma_membrane0.75122181
123MP0003656_abnormal_erythrocyte_physiolo0.74984553
124MP0003890_abnormal_embryonic-extraembry0.74257382
125MP0002332_abnormal_exercise_endurance0.72693088
126MP0001853_heart_inflammation0.72212179
127MP0001529_abnormal_vocalization0.71999136
128MP0005623_abnormal_meninges_morphology0.71061584
129MP0001849_ear_inflammation0.70450687
130MP0000609_abnormal_liver_physiology0.69993611
131MP0005375_adipose_tissue_phenotype0.69944653
132MP0002970_abnormal_white_adipose0.69188050
133MP0001145_abnormal_male_reproductive0.68893819
134MP0002075_abnormal_coat/hair_pigmentati0.68580894
135MP0002111_abnormal_tail_morphology0.68033440
136MP0001929_abnormal_gametogenesis0.66437181
137MP0000467_abnormal_esophagus_morphology0.64073619
138MP0005670_abnormal_white_adipose0.63937770
139MP0005171_absent_coat_pigmentation0.63323114
140MP0002089_abnormal_postnatal_growth/wei0.60506763
141MP0004782_abnormal_surfactant_physiolog0.59939383
142MP0001348_abnormal_lacrimal_gland0.59937380

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.83603027
2Microvesicular hepatic steatosis (HP:0001414)4.61610071
3Myoglobinuria (HP:0002913)4.10280701
4Rhabdomyolysis (HP:0003201)4.03558756
5Increased connective tissue (HP:0009025)3.52751282
6Hepatocellular necrosis (HP:0001404)3.43577354
7Cholecystitis (HP:0001082)3.40465319
8Abnormal gallbladder physiology (HP:0012438)3.40465319
9Ependymoma (HP:0002888)3.28995364
10Exercise-induced myalgia (HP:0003738)3.18884471
11Abnormal number of erythroid precursors (HP:0012131)3.18284202
12Acute encephalopathy (HP:0006846)3.15802554
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14799683
14Type I transferrin isoform profile (HP:0003642)3.10556407
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.07735383
16Muscle fiber inclusion bodies (HP:0100299)3.07287300
17Testicular atrophy (HP:0000029)3.06386056
18Abnormal mitochondria in muscle tissue (HP:0008316)3.05267901
19Abnormality of cells of the erythroid lineage (HP:0012130)2.98194908
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90592373
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90592373
22Abnormal glycosylation (HP:0012345)2.88494822
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88494822
24Abnormal protein N-linked glycosylation (HP:0012347)2.88494822
25Abnormal protein glycosylation (HP:0012346)2.88494822
26Hypoglycemic coma (HP:0001325)2.88113103
27Increased CSF lactate (HP:0002490)2.87605800
28Difficulty climbing stairs (HP:0003551)2.83417630
29Increased serum pyruvate (HP:0003542)2.82795338
30Abnormality of glycolysis (HP:0004366)2.82795338
31Selective tooth agenesis (HP:0001592)2.82308918
32Difficulty running (HP:0009046)2.79047935
33Hyporeflexia of lower limbs (HP:0002600)2.78907937
34Lactic acidosis (HP:0003128)2.73553561
35Ventricular tachycardia (HP:0004756)2.72520094
36Chromsome breakage (HP:0040012)2.72040465
37Nemaline bodies (HP:0003798)2.68729699
38Sudden death (HP:0001699)2.65252129
39Acute necrotizing encephalopathy (HP:0006965)2.63448247
40Microretrognathia (HP:0000308)2.61586294
41Type 1 muscle fiber predominance (HP:0003803)2.60404906
42Multiple enchondromatosis (HP:0005701)2.56881166
43Squamous cell carcinoma (HP:0002860)2.56760994
44Muscle fiber splitting (HP:0003555)2.55405943
45Rough bone trabeculation (HP:0100670)2.55059637
46Mitochondrial inheritance (HP:0001427)2.54387429
47Reduced antithrombin III activity (HP:0001976)2.51786009
48Increased muscle lipid content (HP:0009058)2.51456481
49Shoulder girdle muscle weakness (HP:0003547)2.51337325
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51327748
51Increased intramyocellular lipid droplets (HP:0012240)2.49834895
52Pelvic girdle muscle weakness (HP:0003749)2.48644747
53Ulnar deviation of the wrist (HP:0003049)2.48138521
54Angiofibromas (HP:0010615)2.46009295
55Adenoma sebaceum (HP:0009720)2.46009295
56Progressive external ophthalmoplegia (HP:0000590)2.45036256
57Cerebral edema (HP:0002181)2.43695054
58Abnormality of the astrocytes (HP:0100707)2.40535142
59Astrocytoma (HP:0009592)2.40535142
60Abnormality of the calcaneus (HP:0008364)2.38755009
61Abnormality of reticulocytes (HP:0004312)2.37868671
62Degeneration of anterior horn cells (HP:0002398)2.37262885
63Abnormality of the anterior horn cell (HP:0006802)2.37262885
64Right ventricular cardiomyopathy (HP:0011663)2.34251863
65Hyperammonemia (HP:0001987)2.33156505
66Abnormality of pyrimidine metabolism (HP:0004353)2.31595833
67Ragged-red muscle fibers (HP:0003200)2.31481283
68Rimmed vacuoles (HP:0003805)2.30610700
69Colon cancer (HP:0003003)2.30326732
70Achilles tendon contracture (HP:0001771)2.28120689
71Progressive muscle weakness (HP:0003323)2.26241219
72EMG: myopathic abnormalities (HP:0003458)2.25246266
73Exercise intolerance (HP:0003546)2.24507585
74Abnormality of the preputium (HP:0100587)2.23210858
75Birth length less than 3rd percentile (HP:0003561)2.23202764
76Premature ovarian failure (HP:0008209)2.22281926
77Myopathic facies (HP:0002058)2.20190193
78Areflexia of lower limbs (HP:0002522)2.16403926
79Limb-girdle muscle atrophy (HP:0003797)2.14818821
80Abnormality of the musculature of the pelvis (HP:0001469)2.13567285
81Abnormality of the hip-girdle musculature (HP:0001445)2.13567285
82Abnormality of alanine metabolism (HP:0010916)2.12682906
83Hyperalaninemia (HP:0003348)2.12682906
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12682906
85Palpitations (HP:0001962)2.11105832
86Reticulocytopenia (HP:0001896)2.10967716
87Pancytopenia (HP:0001876)2.10911301
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10220825
89Spastic diplegia (HP:0001264)2.09913233
90Ketoacidosis (HP:0001993)2.09671957
91Abnormality of the lower motor neuron (HP:0002366)2.09076005
92Abnormality of the Achilles tendon (HP:0005109)2.07974129
93Meckel diverticulum (HP:0002245)2.07465041
94Metaphyseal cupping (HP:0003021)2.07456794
95Lipoatrophy (HP:0100578)2.07174346
96Horseshoe kidney (HP:0000085)2.07032532
97Subaortic stenosis (HP:0001682)2.06845404
98Abnormality of the left ventricular outflow tract (HP:0011103)2.06845404
99Aplastic anemia (HP:0001915)2.05075407
100Abnormality of subcutaneous fat tissue (HP:0001001)2.04150586
101Dicarboxylic aciduria (HP:0003215)2.03413176
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03413176
103Distal arthrogryposis (HP:0005684)2.03202741
104Hepatic necrosis (HP:0002605)2.02718487
105Calcaneovalgus deformity (HP:0001848)2.02692039
106Opisthotonus (HP:0002179)2.02097771
107Calf muscle hypertrophy (HP:0008981)1.98865445
108Nausea (HP:0002018)1.98397685
109Abnormality of the ileum (HP:0001549)1.98375384
110Abnormality of cochlea (HP:0000375)1.98318738
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.96616998
112Limb-girdle muscle weakness (HP:0003325)1.96220053
113Ketosis (HP:0001946)1.95765745
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95113753
115Muscle stiffness (HP:0003552)1.95017057
116Protrusio acetabuli (HP:0003179)1.94997690
117Hyperglycinuria (HP:0003108)1.94944872
118Esophageal neoplasm (HP:0100751)1.94670039
119Neoplasm of head and neck (HP:0012288)1.94670039
120Secondary amenorrhea (HP:0000869)1.94068153
121Progressive microcephaly (HP:0000253)1.93427202
122Asymmetric septal hypertrophy (HP:0001670)1.92951523
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.92767144
124Death in infancy (HP:0001522)1.92753726
125Abnormality of serum amino acid levels (HP:0003112)1.92752200
126Lipid accumulation in hepatocytes (HP:0006561)1.92446533
127Absent thumb (HP:0009777)1.92009114
128Entropion (HP:0000621)1.91460821
129Hyperacusis (HP:0010780)1.91427314
130Abnormality of serine family amino acid metabolism (HP:0010894)1.91234297
131Abnormality of glycine metabolism (HP:0010895)1.91234297
132Glioma (HP:0009733)1.90872388
133Reticulocytosis (HP:0001923)1.90819429
134Abnormality of fatty-acid metabolism (HP:0004359)1.90606434
135EMG: neuropathic changes (HP:0003445)1.90337180
136Distal lower limb muscle weakness (HP:0009053)1.90137755
137Trismus (HP:0000211)1.88753418
138Lethargy (HP:0001254)1.87892120
139Retinal dysplasia (HP:0007973)1.87474608
140Hypobetalipoproteinemia (HP:0003563)1.87247364
141Respiratory failure (HP:0002878)1.87205547
142Abnormality of DNA repair (HP:0003254)1.86893405
143CNS demyelination (HP:0007305)1.84656434
144Neoplasm of the adrenal gland (HP:0100631)1.84229567
145Generalized aminoaciduria (HP:0002909)1.83896649
146Ureteral duplication (HP:0000073)1.83502413
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83401493
148Absent epiphyses (HP:0010577)1.83401493
149Muscle hypertrophy of the lower extremities (HP:0008968)1.83081793
150Distal upper limb amyotrophy (HP:0007149)1.83081230
151Upper limb amyotrophy (HP:0009129)1.83081230
152Spastic paraparesis (HP:0002313)1.82902488
153Hand muscle atrophy (HP:0009130)1.82542933
154Abnormality of methionine metabolism (HP:0010901)1.82324969
155Hyperglycinemia (HP:0002154)1.82010296
156Oral leukoplakia (HP:0002745)1.81834155
157Abnormal trabecular bone morphology (HP:0100671)1.81472358
158Breast hypoplasia (HP:0003187)1.80250609
159Abnormality of the gallbladder (HP:0005264)1.79884539
160Emotional lability (HP:0000712)1.79669744
161Neoplasm of the rectum (HP:0100743)1.79294784
162Increased serum lactate (HP:0002151)1.76304866
163Neonatal death (HP:0003811)1.75391285
164Impaired proprioception (HP:0010831)1.75355851
165Megaloblastic anemia (HP:0001889)1.74844404
166Deformed tarsal bones (HP:0008119)1.74423540
167Abnormality of the calf musculature (HP:0001430)1.73157454
168Dilated cardiomyopathy (HP:0001644)1.72709059
169Late onset (HP:0003584)1.71890871
170Muscle fibrillation (HP:0010546)1.71827866
171Cholelithiasis (HP:0001081)1.70988542
172Hypolipoproteinemia (HP:0010981)1.70175751
173Myotonia (HP:0002486)1.69977392
174Medulloblastoma (HP:0002885)1.69795111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.65355506
2VRK23.49556551
3TRIB33.34509839
4SMG13.28696037
5WEE13.13146695
6PKN23.12967480
7BUB13.08831896
8TTN2.98159799
9CDC72.81408376
10BCKDK2.55386823
11IRAK32.53313006
12PDK42.52415945
13PDK32.52415945
14PBK2.47343833
15PIM22.46557902
16EIF2AK12.31348086
17TSSK62.21874760
18NEK22.10877679
19EEF2K2.10826448
20OBSCN1.88731350
21TTK1.81500985
22EPHA21.69406371
23TESK11.67372602
24SCYL21.63421736
25BRSK21.57987329
26TESK21.47906294
27BRSK11.44945427
28CDK81.42241493
29RPS6KB21.37334046
30PLK11.36881716
31FLT31.34791799
32MAP3K81.33496640
33STK161.33150323
34PAK41.31219645
35PASK1.29054560
36CDK41.25316089
37MAP3K101.20584531
38LMTK21.16265918
39VRK11.16166161
40MAP3K111.15395203
41CCNB11.13506415
42AURKB1.13461076
43ACVR1B1.13079884
44ATR1.11652152
45CDK121.11146877
46PLK31.09440435
47MAP2K31.08293255
48PDK21.07914240
49RPS6KA41.03987862
50LIMK11.01460881
51CDK71.01303619
52LRRK20.97449986
53PRKCI0.97240685
54PLK40.92785469
55STK100.91085231
56CSNK1G30.89427596
57NME20.89106157
58LATS20.88794608
59AURKA0.87954150
60PTK60.87917093
61ARAF0.87730294
62MAPKAPK30.87459722
63CHEK10.86544936
64TGFBR10.85211991
65DAPK10.85170642
66FGFR10.83322558
67MTOR0.80906438
68MAP2K20.80114106
69ALK0.79389275
70CLK10.78947336
71CDK90.78847032
72MAPKAPK50.78625256
73ZAK0.78306805
74PRKD30.77264325
75ERN10.77166560
76STK40.75321706
77RPS6KA50.74494878
78CDK60.72456261
79NUAK10.72370016
80RIPK10.71822339
81TAF10.71441544
82MST1R0.71207036
83CSNK1A1L0.71024968
84SRPK10.70324896
85PHKG10.67883293
86PHKG20.67883293
87KDR0.67476713
88STK38L0.66366196
89PDGFRA0.65252349
90CHEK20.64197510
91ILK0.63970643
92MAPK110.63203149
93TLK10.62526318
94RAF10.61134930
95TAOK20.59668650
96CDK20.58859450
97PAK20.58584425
98BRAF0.58459854
99ERBB40.57960350
100MKNK10.54823868
101NEK90.53748638
102CSNK2A10.53614757
103EIF2AK30.53536283
104ABL20.51312461
105AKT20.50762799
106BRD40.50435002
107PAK10.50009817
108NME10.46659006
109LATS10.46574076
110EIF2AK20.45008713
111MAP3K50.44457377
112DYRK30.43383135
113ICK0.40796875
114CSNK1G10.40209855
115CDK10.40184559
116FGFR40.39825507
117CSNK2A20.38961584
118SIK10.38530002
119ATM0.38173304
120PTK20.35539006
121DAPK30.35280038
122WNK40.34617006
123STK30.34190832
124PIM10.32467875
125MAP3K30.31787044
126STK240.31661542
127BMPR1B0.30462651
128CSNK1E0.29838212
129BMX0.28679036
130CDC42BPA0.27797678
131CDK150.27003049
132CDK140.26566844

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.25662673
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.82686620
3DNA replication_Homo sapiens_hsa030303.56099367
4One carbon pool by folate_Homo sapiens_hsa006703.01052557
5Mismatch repair_Homo sapiens_hsa034302.90851467
6Carbon metabolism_Homo sapiens_hsa012002.74948967
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72232590
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70507829
9Biosynthesis of amino acids_Homo sapiens_hsa012302.66549996
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44803968
11RNA transport_Homo sapiens_hsa030132.22024315
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14214038
13Proteasome_Homo sapiens_hsa030502.00405062
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.98503167
15Propanoate metabolism_Homo sapiens_hsa006401.90353945
16Pyruvate metabolism_Homo sapiens_hsa006201.87723449
17Cell cycle_Homo sapiens_hsa041101.86880065
18Fatty acid degradation_Homo sapiens_hsa000711.86829001
19Spliceosome_Homo sapiens_hsa030401.86265661
20Base excision repair_Homo sapiens_hsa034101.85934108
21Pentose phosphate pathway_Homo sapiens_hsa000301.70676936
22Nucleotide excision repair_Homo sapiens_hsa034201.64976221
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.62638646
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56141719
25Selenocompound metabolism_Homo sapiens_hsa004501.51459833
26Fatty acid elongation_Homo sapiens_hsa000621.42560831
27Fatty acid metabolism_Homo sapiens_hsa012121.38890010
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37879655
29Fructose and mannose metabolism_Homo sapiens_hsa000511.33563920
30Homologous recombination_Homo sapiens_hsa034401.30660128
31Pyrimidine metabolism_Homo sapiens_hsa002401.28507161
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.24372339
33N-Glycan biosynthesis_Homo sapiens_hsa005101.18779734
34Oxidative phosphorylation_Homo sapiens_hsa001901.18636765
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18623796
36Arginine biosynthesis_Homo sapiens_hsa002201.18375138
37p53 signaling pathway_Homo sapiens_hsa041151.16017560
38Parkinsons disease_Homo sapiens_hsa050121.15801199
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12553244
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06620710
41Galactose metabolism_Homo sapiens_hsa000521.05362328
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.05131539
43Lysine degradation_Homo sapiens_hsa003101.04409535
44RNA polymerase_Homo sapiens_hsa030200.98733198
45Nitrogen metabolism_Homo sapiens_hsa009100.95585895
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.92683039
47Other glycan degradation_Homo sapiens_hsa005110.92174124
48Basal transcription factors_Homo sapiens_hsa030220.91355764
49mRNA surveillance pathway_Homo sapiens_hsa030150.86683875
50Tryptophan metabolism_Homo sapiens_hsa003800.82916587
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81307508
52Huntingtons disease_Homo sapiens_hsa050160.80403393
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79766987
54Butanoate metabolism_Homo sapiens_hsa006500.78492335
55Viral carcinogenesis_Homo sapiens_hsa052030.75426788
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75171535
57Ribosome_Homo sapiens_hsa030100.72525044
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70139651
59RNA degradation_Homo sapiens_hsa030180.70107302
60Oocyte meiosis_Homo sapiens_hsa041140.69957100
61Sulfur metabolism_Homo sapiens_hsa009200.69020774
62Glucagon signaling pathway_Homo sapiens_hsa049220.66356970
63Dilated cardiomyopathy_Homo sapiens_hsa054140.64540449
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63225132
65Starch and sucrose metabolism_Homo sapiens_hsa005000.62615378
66HIF-1 signaling pathway_Homo sapiens_hsa040660.61879143
67Viral myocarditis_Homo sapiens_hsa054160.61793053
68Epstein-Barr virus infection_Homo sapiens_hsa051690.60826197
69Sulfur relay system_Homo sapiens_hsa041220.60113706
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59882575
71Steroid biosynthesis_Homo sapiens_hsa001000.59499431
72Fanconi anemia pathway_Homo sapiens_hsa034600.58825534
73Tyrosine metabolism_Homo sapiens_hsa003500.57087718
74AMPK signaling pathway_Homo sapiens_hsa041520.56990319
75Systemic lupus erythematosus_Homo sapiens_hsa053220.56979316
76PPAR signaling pathway_Homo sapiens_hsa033200.56763087
77Folate biosynthesis_Homo sapiens_hsa007900.56596820
78Non-homologous end-joining_Homo sapiens_hsa034500.55773615
79Arginine and proline metabolism_Homo sapiens_hsa003300.55333376
80Purine metabolism_Homo sapiens_hsa002300.54393011
81Bladder cancer_Homo sapiens_hsa052190.54281543
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53342698
83Small cell lung cancer_Homo sapiens_hsa052220.51439795
84Insulin signaling pathway_Homo sapiens_hsa049100.51284071
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51047231
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50588171
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.50554847
88Cardiac muscle contraction_Homo sapiens_hsa042600.50084720
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50055337
90Peroxisome_Homo sapiens_hsa041460.48516198
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48281238
92Legionellosis_Homo sapiens_hsa051340.48217379
93Thyroid cancer_Homo sapiens_hsa052160.47754195
94Alzheimers disease_Homo sapiens_hsa050100.47641320
95Insulin resistance_Homo sapiens_hsa049310.47166323
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46270432
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45822432
98HTLV-I infection_Homo sapiens_hsa051660.45261276
99mTOR signaling pathway_Homo sapiens_hsa041500.43221049
100beta-Alanine metabolism_Homo sapiens_hsa004100.42660882
101Glutathione metabolism_Homo sapiens_hsa004800.42058476
102Fat digestion and absorption_Homo sapiens_hsa049750.41341613
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40518710
104Phenylalanine metabolism_Homo sapiens_hsa003600.39142096
105Vitamin B6 metabolism_Homo sapiens_hsa007500.38300846
106Hippo signaling pathway_Homo sapiens_hsa043900.37808020
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36281725
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36081159
109Protein export_Homo sapiens_hsa030600.34344243
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33457923
111MicroRNAs in cancer_Homo sapiens_hsa052060.31244152
112Tight junction_Homo sapiens_hsa045300.30826383
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.30616100
114Vitamin digestion and absorption_Homo sapiens_hsa049770.29379916
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29160431
116Metabolic pathways_Homo sapiens_hsa011000.27799864
117Fatty acid biosynthesis_Homo sapiens_hsa000610.26288554
118Antigen processing and presentation_Homo sapiens_hsa046120.25805373
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.24887033
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21422106
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16611890
122Vibrio cholerae infection_Homo sapiens_hsa051100.14446637
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12379157
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.08879282
125Lysosome_Homo sapiens_hsa041420.07887171

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