PMCHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.98698848
2protein K11-linked deubiquitination (GO:0035871)4.81513751
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54885816
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.54885816
5NADH dehydrogenase complex assembly (GO:0010257)4.54885816
6mitochondrial calcium ion transport (GO:0006851)4.17913871
7tryptophan catabolic process (GO:0006569)4.14899767
8indole-containing compound catabolic process (GO:0042436)4.14899767
9indolalkylamine catabolic process (GO:0046218)4.14899767
10DNA deamination (GO:0045006)4.13126790
11positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.96198742
12fucose catabolic process (GO:0019317)3.91737351
13L-fucose metabolic process (GO:0042354)3.91737351
14L-fucose catabolic process (GO:0042355)3.91737351
15protein complex biogenesis (GO:0070271)3.89581655
16kynurenine metabolic process (GO:0070189)3.86647310
17indolalkylamine metabolic process (GO:0006586)3.84890211
18platelet dense granule organization (GO:0060155)3.82280625
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.80646306
20kidney morphogenesis (GO:0060993)3.78464652
21response to pheromone (GO:0019236)3.76318888
22vitamin transmembrane transport (GO:0035461)3.76093723
23tryptophan metabolic process (GO:0006568)3.67841587
24neural tube formation (GO:0001841)3.66289377
25mitochondrial respiratory chain complex assembly (GO:0033108)3.60105758
26atrial cardiac muscle cell action potential (GO:0086014)3.43093958
27cysteine metabolic process (GO:0006534)3.38846080
28pseudouridine synthesis (GO:0001522)3.33962688
29cellular ketone body metabolic process (GO:0046950)3.32873883
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28405470
31detection of light stimulus involved in sensory perception (GO:0050962)3.27720296
32detection of light stimulus involved in visual perception (GO:0050908)3.27720296
33protein-cofactor linkage (GO:0018065)3.25238576
34piRNA metabolic process (GO:0034587)3.23943340
35preassembly of GPI anchor in ER membrane (GO:0016254)3.20950220
36regulation of cilium movement (GO:0003352)3.20384973
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19734374
38negative regulation of telomere maintenance (GO:0032205)2.98595723
39ketone body metabolic process (GO:1902224)2.97873590
40water-soluble vitamin biosynthetic process (GO:0042364)2.94689678
41indole-containing compound metabolic process (GO:0042430)2.94625428
42negative regulation of mast cell activation (GO:0033004)2.94325947
43regulation of action potential (GO:0098900)2.92803468
44regulation of memory T cell differentiation (GO:0043380)2.90373510
45mitochondrial calcium ion homeostasis (GO:0051560)2.85779554
46regulation of microtubule-based movement (GO:0060632)2.85527969
47regulation of meiosis I (GO:0060631)2.82946336
48L-methionine salvage (GO:0071267)2.81362431
49L-methionine biosynthetic process (GO:0071265)2.81362431
50amino acid salvage (GO:0043102)2.81362431
51pyrimidine-containing compound transmembrane transport (GO:0072531)2.79853796
52rRNA catabolic process (GO:0016075)2.78570294
53oxidative demethylation (GO:0070989)2.76567170
54pyrimidine nucleobase catabolic process (GO:0006208)2.74083324
55drug catabolic process (GO:0042737)2.73962496
56primary amino compound metabolic process (GO:1901160)2.73701027
57sulfation (GO:0051923)2.71026282
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69205231
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69205231
60cornea development in camera-type eye (GO:0061303)2.69020059
61nonmotile primary cilium assembly (GO:0035058)2.67473058
62respiratory chain complex IV assembly (GO:0008535)2.67169531
63adenosine metabolic process (GO:0046085)2.66480018
64serotonin receptor signaling pathway (GO:0007210)2.66229054
65reflex (GO:0060004)2.65981155
66postsynaptic membrane organization (GO:0001941)2.65842532
67regulation of hippo signaling (GO:0035330)2.65576944
68DNA double-strand break processing (GO:0000729)2.63704040
69retinal cone cell development (GO:0046549)2.63041228
70synaptic transmission, cholinergic (GO:0007271)2.62635618
71DNA methylation involved in gamete generation (GO:0043046)2.61890596
72auditory receptor cell stereocilium organization (GO:0060088)2.60542686
73adult feeding behavior (GO:0008343)2.60153508
74behavioral response to ethanol (GO:0048149)2.59452622
75cellular biogenic amine catabolic process (GO:0042402)2.59241766
76amine catabolic process (GO:0009310)2.59241766
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.57963520
78maturation of 5.8S rRNA (GO:0000460)2.56938807
79peristalsis (GO:0030432)2.54827522
80positive regulation of meiosis (GO:0045836)2.53646441
81nucleobase catabolic process (GO:0046113)2.52832944
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52721134
83glycerophospholipid catabolic process (GO:0046475)2.52609862
84cilium morphogenesis (GO:0060271)2.51774983
85sex differentiation (GO:0007548)2.51634185
86axoneme assembly (GO:0035082)2.51547285
87regulation of hexokinase activity (GO:1903299)2.48778933
88regulation of glucokinase activity (GO:0033131)2.48778933
89epithelial cilium movement (GO:0003351)2.47965542
90replication fork processing (GO:0031297)2.47871760
91multicellular organism reproduction (GO:0032504)2.47700366
92proline transport (GO:0015824)2.47551059
93aromatic amino acid family catabolic process (GO:0009074)2.47446830
94mannosylation (GO:0097502)2.46500995
95negative regulation of calcium ion transport into cytosol (GO:0010523)2.45807008
96negative regulation of interleukin-1 beta production (GO:0032691)2.44991064
97prenylation (GO:0097354)2.44705872
98protein prenylation (GO:0018342)2.44705872
99photoreceptor cell development (GO:0042461)2.44672237
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.44178803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.85467763
2VDR_22108803_ChIP-Seq_LS180_Human3.48279076
3GBX2_23144817_ChIP-Seq_PC3_Human3.16865477
4IGF1R_20145208_ChIP-Seq_DFB_Human3.11834065
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69741752
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54031769
7TAF15_26573619_Chip-Seq_HEK293_Human2.50197495
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.28880388
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28391591
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.17518417
11EZH2_22144423_ChIP-Seq_EOC_Human2.16918524
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13309471
13* FUS_26573619_Chip-Seq_HEK293_Human2.11949149
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10408922
15* EWS_26573619_Chip-Seq_HEK293_Human2.07673051
16ER_23166858_ChIP-Seq_MCF-7_Human2.07278926
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04070337
18P300_19829295_ChIP-Seq_ESCs_Human1.95591486
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94977689
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91919830
21TP53_22573176_ChIP-Seq_HFKS_Human1.77108596
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74647142
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71473059
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61209435
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58815544
26IRF1_19129219_ChIP-ChIP_H3396_Human1.56150099
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56105470
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.56005424
29STAT3_23295773_ChIP-Seq_U87_Human1.55385063
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54332483
31BCAT_22108803_ChIP-Seq_LS180_Human1.54183781
32AR_25329375_ChIP-Seq_VCAP_Human1.54122092
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.52743396
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51479817
35SMAD4_21799915_ChIP-Seq_A2780_Human1.51404110
36* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49627762
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47744554
38TCF4_23295773_ChIP-Seq_U87_Human1.45862533
39MYC_18940864_ChIP-ChIP_HL60_Human1.44986665
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43164563
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41934980
42CBP_20019798_ChIP-Seq_JUKART_Human1.41934980
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.41905172
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41792673
45REST_21632747_ChIP-Seq_MESCs_Mouse1.40293867
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37332015
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36429315
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.36266593
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36010937
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35281815
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.35281815
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.35228991
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34551881
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33084229
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33084229
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.30951453
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30779929
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30701120
59* TCF4_22108803_ChIP-Seq_LS180_Human1.30693026
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28490839
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27545093
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.27466639
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27109868
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25545603
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.24822661
66RUNX2_22187159_ChIP-Seq_PCA_Human1.24286223
67SOX2_19829295_ChIP-Seq_ESCs_Human1.21739174
68NANOG_19829295_ChIP-Seq_ESCs_Human1.21739174
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21715171
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.21590820
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21445532
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20477065
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.20301124
74AR_21572438_ChIP-Seq_LNCaP_Human1.18857430
75AR_20517297_ChIP-Seq_VCAP_Human1.17112903
76NCOR_22424771_ChIP-Seq_293T_Human1.16370364
77P53_22387025_ChIP-Seq_ESCs_Mouse1.14526866
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14423128
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14127327
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.13867854
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.13579852
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13055537
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13041632
84RNF2_27304074_Chip-Seq_NSC_Mouse1.11839856
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11395467
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11107158
87HOXB7_26014856_ChIP-Seq_BT474_Human1.09613803
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08881227
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.08280147
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07876834
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.06915823
92CDX2_22108803_ChIP-Seq_LS180_Human1.05165655
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03931727
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02027274
95TBL1_22424771_ChIP-Seq_293T_Human1.00759319
96P300_18555785_Chip-Seq_ESCs_Mouse0.99756448
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.98972966
98PHF8_20622853_ChIP-Seq_HELA_Human0.97601382
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.97089525
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.96981101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation2.86037607
2MP0004147_increased_porphyrin_level2.85790439
3MP0005551_abnormal_eye_electrophysiolog2.66711436
4MP0003195_calcinosis2.59250863
5MP0002653_abnormal_ependyma_morphology2.41519383
6MP0003646_muscle_fatigue2.36877921
7MP0002102_abnormal_ear_morphology2.28008025
8MP0008877_abnormal_DNA_methylation2.23173766
9MP0002837_dystrophic_cardiac_calcinosis2.11810390
10MP0001968_abnormal_touch/_nociception2.11423134
11MP0009046_muscle_twitch2.11010128
12MP0008872_abnormal_physiological_respon2.05255590
13MP0002736_abnormal_nociception_after2.04968938
14MP0005253_abnormal_eye_physiology2.03721556
15MP0006072_abnormal_retinal_apoptosis2.03670106
16MP0000569_abnormal_digit_pigmentation2.02667906
17MP0001984_abnormal_olfaction2.02234493
18MP0001986_abnormal_taste_sensitivity1.98863237
19MP0002938_white_spotting1.98020262
20MP0009745_abnormal_behavioral_response1.94866835
21MP0005645_abnormal_hypothalamus_physiol1.94309184
22MP0004885_abnormal_endolymph1.94244838
23MP0005360_urolithiasis1.87662294
24MP0003880_abnormal_central_pattern1.84784161
25MP0008875_abnormal_xenobiotic_pharmacok1.79716488
26MP0005174_abnormal_tail_pigmentation1.78857651
27MP0005646_abnormal_pituitary_gland1.72983381
28MP0006292_abnormal_olfactory_placode1.69964045
29MP0002735_abnormal_chemical_nociception1.69374591
30MP0002876_abnormal_thyroid_physiology1.63344518
31MP0002009_preneoplasia1.61012400
32MP0002272_abnormal_nervous_system1.60894679
33MP0006276_abnormal_autonomic_nervous1.60891196
34MP0001501_abnormal_sleep_pattern1.59838958
35MP0000427_abnormal_hair_cycle1.56128324
36MP0005084_abnormal_gallbladder_morpholo1.53360785
37MP0001486_abnormal_startle_reflex1.51535591
38MP0001529_abnormal_vocalization1.51448608
39MP0005167_abnormal_blood-brain_barrier1.50516065
40MP0002138_abnormal_hepatobiliary_system1.46430264
41MP0003252_abnormal_bile_duct1.41898067
42MP0004924_abnormal_behavior1.41547306
43MP0005386_behavior/neurological_phenoty1.41547306
44MP0002234_abnormal_pharynx_morphology1.39501011
45MP0002638_abnormal_pupillary_reflex1.36393349
46MP0001764_abnormal_homeostasis1.35538477
47MP0003787_abnormal_imprinting1.35390979
48MP0002064_seizures1.34349361
49MP0002733_abnormal_thermal_nociception1.33848979
50MP0001970_abnormal_pain_threshold1.32133286
51MP0004133_heterotaxia1.24449809
52MP0002572_abnormal_emotion/affect_behav1.24307090
53MP0001485_abnormal_pinna_reflex1.19116978
54MP0000631_abnormal_neuroendocrine_gland1.16833866
55MP0000015_abnormal_ear_pigmentation1.15370956
56MP0002254_reproductive_system_inflammat1.12373823
57MP0004142_abnormal_muscle_tone1.12104620
58MP0005332_abnormal_amino_acid1.10998617
59MP0002063_abnormal_learning/memory/cond1.09846405
60MP0003635_abnormal_synaptic_transmissio1.09724336
61MP0002095_abnormal_skin_pigmentation1.09624214
62MP0003011_delayed_dark_adaptation1.07244554
63MP0003137_abnormal_impulse_conducting1.07012338
64MP0000372_irregular_coat_pigmentation1.05265976
65MP0003136_yellow_coat_color1.03168987
66MP0000230_abnormal_systemic_arterial1.03067544
67MP0010386_abnormal_urinary_bladder1.00554528
68MP0002160_abnormal_reproductive_system1.00503406
69MP0000383_abnormal_hair_follicle0.99576407
70MP0003718_maternal_effect0.99433067
71MP0005195_abnormal_posterior_eye0.97526270
72MP0004742_abnormal_vestibular_system0.97429462
73MP0005389_reproductive_system_phenotype0.94739693
74MP0002557_abnormal_social/conspecific_i0.93751576
75MP0002909_abnormal_adrenal_gland0.90045210
76MP0002928_abnormal_bile_duct0.89954246
77MP0005410_abnormal_fertilization0.88607951
78MP0005377_hearing/vestibular/ear_phenot0.87093782
79MP0003878_abnormal_ear_physiology0.87093782
80MP0002067_abnormal_sensory_capabilities0.84867529
81MP0005085_abnormal_gallbladder_physiolo0.83449972
82MP0003183_abnormal_peptide_metabolism0.83051324
83MP0002734_abnormal_mechanical_nocicepti0.82946628
84MP0000647_abnormal_sebaceous_gland0.82902340
85MP0000613_abnormal_salivary_gland0.82732051
86MP0000538_abnormal_urinary_bladder0.82382288
87MP0001324_abnormal_eye_pigmentation0.81601852
88MP0010329_abnormal_lipoprotein_level0.80861572
89MP0002752_abnormal_somatic_nervous0.80659240
90MP0008058_abnormal_DNA_repair0.79585094
91MP0005379_endocrine/exocrine_gland_phen0.78569548
92MP0002693_abnormal_pancreas_physiology0.78174510
93MP0001905_abnormal_dopamine_level0.77670396
94MP0008995_early_reproductive_senescence0.76453944
95MP0002184_abnormal_innervation0.75835128
96MP0003698_abnormal_male_reproductive0.75346943
97MP0002069_abnormal_eating/drinking_beha0.74774006
98MP0002163_abnormal_gland_morphology0.73950202
99MP0005391_vision/eye_phenotype0.73594200
100MP0003890_abnormal_embryonic-extraembry0.73334954

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)5.18992673
2Inability to walk (HP:0002540)4.00614402
3True hermaphroditism (HP:0010459)3.99736978
4Abnormality of midbrain morphology (HP:0002418)3.94295344
5Molar tooth sign on MRI (HP:0002419)3.94295344
6Pancreatic fibrosis (HP:0100732)3.94196348
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.82961128
8Abnormality of alanine metabolism (HP:0010916)3.82961128
9Hyperalaninemia (HP:0003348)3.82961128
10Congenital stationary night blindness (HP:0007642)3.76737846
11Nephronophthisis (HP:0000090)3.73297757
12Type II lissencephaly (HP:0007260)3.62642791
13Congenital sensorineural hearing impairment (HP:0008527)3.58366193
14Pendular nystagmus (HP:0012043)3.54486417
15Birth length less than 3rd percentile (HP:0003561)3.45180608
16Abnormality of the renal cortex (HP:0011035)3.42800912
17Attenuation of retinal blood vessels (HP:0007843)3.32652874
18Hyperventilation (HP:0002883)3.32472898
19Abnormality of the renal medulla (HP:0100957)3.22282219
20Medial flaring of the eyebrow (HP:0010747)3.10986275
21Abolished electroretinogram (ERG) (HP:0000550)3.09178784
22Abnormal rod and cone electroretinograms (HP:0008323)2.70760134
23Lissencephaly (HP:0001339)2.66138950
24Chorioretinal atrophy (HP:0000533)2.59063128
25Cystic liver disease (HP:0006706)2.58968786
26Renal cortical cysts (HP:0000803)2.57939808
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56763978
28Gait imbalance (HP:0002141)2.56524868
29Genetic anticipation (HP:0003743)2.48328325
30Keratoconus (HP:0000563)2.47655199
31Increased corneal curvature (HP:0100692)2.47655199
32Nephrogenic diabetes insipidus (HP:0009806)2.47612623
33Congenital primary aphakia (HP:0007707)2.47544140
34Progressive cerebellar ataxia (HP:0002073)2.44896113
35Progressive inability to walk (HP:0002505)2.43490668
36Tubular atrophy (HP:0000092)2.42456127
37Gaze-evoked nystagmus (HP:0000640)2.41761911
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33650634
39Chronic hepatic failure (HP:0100626)2.33127078
40Cerebellar dysplasia (HP:0007033)2.26968550
41Sclerocornea (HP:0000647)2.23162555
42Abnormal drinking behavior (HP:0030082)2.21671303
43Polydipsia (HP:0001959)2.21671303
44Decreased central vision (HP:0007663)2.19930920
45Broad-based gait (HP:0002136)2.16754496
46Genital tract atresia (HP:0001827)2.13696716
47Constricted visual fields (HP:0001133)2.11629284
48Anencephaly (HP:0002323)2.09368348
49Vaginal atresia (HP:0000148)2.08009758
50Protruding tongue (HP:0010808)2.06360577
51Focal motor seizures (HP:0011153)2.06203802
52Poor coordination (HP:0002370)2.04994704
53Microretrognathia (HP:0000308)2.04709774
54Large for gestational age (HP:0001520)2.03058023
55Disproportionate short-trunk short stature (HP:0003521)2.01688917
56Bile duct proliferation (HP:0001408)2.00782059
57Abnormal biliary tract physiology (HP:0012439)2.00782059
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.00222421
59Neuroendocrine neoplasm (HP:0100634)1.99656747
60Furrowed tongue (HP:0000221)1.99656026
61Focal seizures (HP:0007359)1.98268538
62Postaxial foot polydactyly (HP:0001830)1.97846044
63Patellar aplasia (HP:0006443)1.97502006
64Morphological abnormality of the pyramidal tract (HP:0002062)1.97198253
65Decreased circulating renin level (HP:0003351)1.92948040
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.92606295
67Aplasia/Hypoplasia of the patella (HP:0006498)1.92241511
68Severe muscular hypotonia (HP:0006829)1.91348664
69Male pseudohermaphroditism (HP:0000037)1.91141148
70Pheochromocytoma (HP:0002666)1.90449027
71Mutism (HP:0002300)1.90262853
72Bony spicule pigmentary retinopathy (HP:0007737)1.88068947
73Congenital hepatic fibrosis (HP:0002612)1.86525420
74Pancreatic islet-cell hyperplasia (HP:0004510)1.85959264
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81815011
76Clumsiness (HP:0002312)1.81790868
77Aplasia/Hypoplasia of the sternum (HP:0006714)1.81279293
78Retinitis pigmentosa (HP:0000510)1.80903715
79Polyuria (HP:0000103)1.80168705
80Dandy-Walker malformation (HP:0001305)1.80153671
81Optic nerve hypoplasia (HP:0000609)1.79894225
82Hypothermia (HP:0002045)1.79239785
83Absent speech (HP:0001344)1.78932708
84Hemiparesis (HP:0001269)1.78312187
85Pachygyria (HP:0001302)1.78246907
86Abnormal respiratory motile cilium morphology (HP:0005938)1.76780708
87Abnormal respiratory epithelium morphology (HP:0012253)1.76780708
88Dialeptic seizures (HP:0011146)1.75563072
89Confusion (HP:0001289)1.74385803
90Occipital encephalocele (HP:0002085)1.74291017
91Abnormality of the pons (HP:0007361)1.72051520
92Retinal dysplasia (HP:0007973)1.71636068
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.70587349
94Hypoplasia of the fovea (HP:0007750)1.70587349
95Fair hair (HP:0002286)1.68718113
96Duplicated collecting system (HP:0000081)1.66091750
97Concave nail (HP:0001598)1.65138266
98Abnormality of the renal collecting system (HP:0004742)1.63767155
99Postaxial hand polydactyly (HP:0001162)1.61839566
100Acute encephalopathy (HP:0006846)1.61705251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.15321540
2ACVR1B3.81492245
3BMPR1B3.69537687
4ADRBK23.01893342
5MAP4K22.87367637
6CASK2.62833222
7DAPK22.49623955
8ZAK2.45638229
9TXK2.37407087
10PINK12.29553697
11WNK32.29036214
12GRK12.27384437
13NEK12.16844806
14MAPK131.93154277
15NUAK11.88977117
16STK31.71467756
17WNK41.67087244
18NEK21.62100092
19VRK21.61691898
20TAOK31.58310304
21EIF2AK31.57083599
22OXSR11.51469557
23TRIM281.39774619
24TGFBR11.37513820
25TLK11.34001416
26ERBB31.33264578
27STK38L1.29839144
28ADRBK11.15872756
29TIE11.15506862
30BLK1.12097034
31MAP3K41.05869253
32CDK191.05041967
33WEE10.94445389
34YES10.94269724
35PHKG10.92447876
36PHKG20.92447876
37MKNK20.90750938
38CAMKK20.90281046
39VRK10.90079193
40EIF2AK20.89807579
41PLK40.86233837
42PAK30.84412836
43MAPKAPK50.82162963
44INSRR0.82004103
45CSNK1G10.81974317
46STK390.78875868
47MARK10.77521625
48CAMK10.76211141
49CAMK40.74703005
50MAPKAPK30.72550293
51CSNK1G20.71444309
52PTK2B0.70100436
53PRKCE0.69799976
54CSNK1G30.68551837
55PLK20.68440623
56CAMK2A0.67406937
57MST40.65917350
58EPHA40.65670949
59PRKCG0.65568528
60DYRK20.65535353
61BCR0.63565426
62CSNK1A10.61360584
63TNIK0.59431939
64BCKDK0.56030660
65MAP2K60.55678990
66CAMKK10.55359597
67MAP2K70.54503236
68CSNK1A1L0.50370710
69MAP2K10.50311129
70PRKCQ0.49690168
71BUB10.47964941
72MAP3K70.45430090
73NTRK20.44845092
74TNK20.43793375
75NME10.42558806
76PRKCZ0.41931882
77IRAK10.41847531
78PLK30.40825679
79UHMK10.40328930
80CHEK20.40325639
81SYK0.38550526
82SGK20.38110269
83PNCK0.38102574
84TAF10.36475192
85FER0.36436338
86TEC0.35714804
87RPS6KA60.35324305
88PRKCH0.34009613
89CAMK1G0.34001320
90NTRK30.33324875
91IGF1R0.32899980
92MKNK10.32291870
93CDK30.32254951
94PRKAA20.31108282
95RPS6KA50.30181022
96PRKACA0.29499825
97CCNB10.28363860
98SGK2230.28121900
99SGK4940.28121900
100PIK3CA0.27789300

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.78099171
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.76686122
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.69416215
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63807256
5Linoleic acid metabolism_Homo sapiens_hsa005912.52501493
6Butanoate metabolism_Homo sapiens_hsa006502.38507721
7Selenocompound metabolism_Homo sapiens_hsa004502.35823088
8Nitrogen metabolism_Homo sapiens_hsa009102.30417701
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22831077
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18270612
11Nicotine addiction_Homo sapiens_hsa050332.06701519
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06480896
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.05737046
14Tryptophan metabolism_Homo sapiens_hsa003802.01939359
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.92973803
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90573847
17Ether lipid metabolism_Homo sapiens_hsa005651.90417634
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72863989
19Propanoate metabolism_Homo sapiens_hsa006401.70479618
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69157695
21Vitamin digestion and absorption_Homo sapiens_hsa049771.58007483
22Basal transcription factors_Homo sapiens_hsa030221.54503553
23RNA degradation_Homo sapiens_hsa030181.54484966
24Homologous recombination_Homo sapiens_hsa034401.52402319
25RNA polymerase_Homo sapiens_hsa030201.41875022
26Morphine addiction_Homo sapiens_hsa050321.39735900
27Olfactory transduction_Homo sapiens_hsa047401.38801635
28Caffeine metabolism_Homo sapiens_hsa002321.36977418
29Protein export_Homo sapiens_hsa030601.36529442
30Taste transduction_Homo sapiens_hsa047421.31762195
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30327115
32Oxidative phosphorylation_Homo sapiens_hsa001901.28936831
33Fanconi anemia pathway_Homo sapiens_hsa034601.27403160
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.25247900
35GABAergic synapse_Homo sapiens_hsa047271.24303800
36Serotonergic synapse_Homo sapiens_hsa047261.21744332
37One carbon pool by folate_Homo sapiens_hsa006701.18510196
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17817204
39Sulfur metabolism_Homo sapiens_hsa009201.17577596
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17347849
41ABC transporters_Homo sapiens_hsa020101.15614439
42Retinol metabolism_Homo sapiens_hsa008301.07897877
43Peroxisome_Homo sapiens_hsa041461.07209780
44Circadian entrainment_Homo sapiens_hsa047131.03118883
45Chemical carcinogenesis_Homo sapiens_hsa052041.02628052
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01297657
47Arachidonic acid metabolism_Homo sapiens_hsa005900.98930419
48Insulin secretion_Homo sapiens_hsa049110.98247862
49Glutamatergic synapse_Homo sapiens_hsa047240.96632469
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94754432
51Regulation of autophagy_Homo sapiens_hsa041400.94162967
52Salivary secretion_Homo sapiens_hsa049700.92940896
53Collecting duct acid secretion_Homo sapiens_hsa049660.92693753
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85718476
55Sulfur relay system_Homo sapiens_hsa041220.84765911
56Long-term depression_Homo sapiens_hsa047300.84503982
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84316523
58Non-homologous end-joining_Homo sapiens_hsa034500.82781364
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.80182294
60Purine metabolism_Homo sapiens_hsa002300.79751991
61Ovarian steroidogenesis_Homo sapiens_hsa049130.78037464
62Glycerolipid metabolism_Homo sapiens_hsa005610.76990121
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76776769
64Parkinsons disease_Homo sapiens_hsa050120.75421527
65Fatty acid degradation_Homo sapiens_hsa000710.73867344
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.71944071
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71812789
68Calcium signaling pathway_Homo sapiens_hsa040200.70118778
69Dorso-ventral axis formation_Homo sapiens_hsa043200.68947294
70Fatty acid biosynthesis_Homo sapiens_hsa000610.66514171
71Metabolic pathways_Homo sapiens_hsa011000.63210741
72beta-Alanine metabolism_Homo sapiens_hsa004100.62504137
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61805442
74Fat digestion and absorption_Homo sapiens_hsa049750.59827984
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57841192
76Pyrimidine metabolism_Homo sapiens_hsa002400.57727080
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57205418
78Fatty acid metabolism_Homo sapiens_hsa012120.56617908
79Dopaminergic synapse_Homo sapiens_hsa047280.56355789
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53148601
81Alzheimers disease_Homo sapiens_hsa050100.49754387
82Huntingtons disease_Homo sapiens_hsa050160.47556152
83Histidine metabolism_Homo sapiens_hsa003400.47076429
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46527843
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46370463
86Primary immunodeficiency_Homo sapiens_hsa053400.43487783
87Oxytocin signaling pathway_Homo sapiens_hsa049210.40480599
88cAMP signaling pathway_Homo sapiens_hsa040240.40285519
89Arginine biosynthesis_Homo sapiens_hsa002200.40024598
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.38541903
91Gastric acid secretion_Homo sapiens_hsa049710.37583288
92Cholinergic synapse_Homo sapiens_hsa047250.37449174
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36256904
94Type I diabetes mellitus_Homo sapiens_hsa049400.35485796
95Amphetamine addiction_Homo sapiens_hsa050310.33864162
96Nucleotide excision repair_Homo sapiens_hsa034200.33667010
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.33249255
98Sphingolipid metabolism_Homo sapiens_hsa006000.33236606
99Asthma_Homo sapiens_hsa053100.33051069
100Cocaine addiction_Homo sapiens_hsa050300.32988300

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »