PM20D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.91644560
2cardiac myofibril assembly (GO:0055003)6.29891366
3tricarboxylic acid cycle (GO:0006099)6.23448073
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.97064829
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.89774333
6carnitine shuttle (GO:0006853)5.75891294
7myofibril assembly (GO:0030239)5.74957578
8negative regulation of potassium ion transmembrane transport (GO:1901380)5.44671250
9DNA unwinding involved in DNA replication (GO:0006268)5.41827955
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.41799828
11muscle filament sliding (GO:0030049)5.36225121
12actin-myosin filament sliding (GO:0033275)5.36225121
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.31517894
14fatty acid transmembrane transport (GO:1902001)5.30290443
15lysine metabolic process (GO:0006553)5.29773419
16lysine catabolic process (GO:0006554)5.29773419
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.25493313
18cardiac muscle contraction (GO:0060048)5.25148226
192-oxoglutarate metabolic process (GO:0006103)5.15953449
20nuclear pore complex assembly (GO:0051292)5.05239497
21regulation of skeletal muscle contraction (GO:0014819)5.04734067
22nuclear pore organization (GO:0006999)4.99870357
23plasma membrane repair (GO:0001778)4.89934557
24regulation of acyl-CoA biosynthetic process (GO:0050812)4.87387116
25aspartate family amino acid catabolic process (GO:0009068)4.86615548
26cardiac muscle cell development (GO:0055013)4.77761398
27mitotic sister chromatid cohesion (GO:0007064)4.77624654
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73409691
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.69190256
30ventricular cardiac muscle cell action potential (GO:0086005)4.48469136
31regulation of actin filament-based movement (GO:1903115)4.47102895
32cardiac cell development (GO:0055006)4.45122369
33regulation of cofactor metabolic process (GO:0051193)4.44053528
34regulation of coenzyme metabolic process (GO:0051196)4.44053528
35sarcoplasmic reticulum calcium ion transport (GO:0070296)4.43351696
36fatty acid beta-oxidation (GO:0006635)4.38824363
37NADH metabolic process (GO:0006734)4.35496647
38actin-mediated cell contraction (GO:0070252)4.32643217
39DNA strand elongation involved in DNA replication (GO:0006271)4.32393836
40cardiac muscle hypertrophy (GO:0003300)4.28438567
41actomyosin structure organization (GO:0031032)4.27200711
42carnitine transmembrane transport (GO:1902603)4.26333477
43branched-chain amino acid catabolic process (GO:0009083)4.26028399
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.25818631
45regulation of DNA endoreduplication (GO:0032875)4.22585892
46positive regulation of mitotic sister chromatid separation (GO:1901970)4.21580963
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.21580963
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.21580963
49creatine metabolic process (GO:0006600)4.20223702
50striated muscle contraction (GO:0006941)4.19568229
51regulation of relaxation of muscle (GO:1901077)4.14740244
52DNA strand elongation (GO:0022616)4.13441663
53DNA replication initiation (GO:0006270)4.12848364
54regulation of fatty acid oxidation (GO:0046320)4.10518866
55oxaloacetate metabolic process (GO:0006107)4.07952205
56striated muscle hypertrophy (GO:0014897)4.07730055
57regulation of sequestering of triglyceride (GO:0010889)4.07064323
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.00314922
59succinate metabolic process (GO:0006105)3.99153460
60cell communication involved in cardiac conduction (GO:0086065)3.98541096
61tricarboxylic acid metabolic process (GO:0072350)3.97054855
62amino-acid betaine transport (GO:0015838)3.95794023
63carnitine transport (GO:0015879)3.95794023
64cardiac muscle tissue morphogenesis (GO:0055008)3.95702702
65branched-chain amino acid metabolic process (GO:0009081)3.90459734
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89611391
67valine metabolic process (GO:0006573)3.81849776
68adult heart development (GO:0007512)3.81763280
69fatty acid catabolic process (GO:0009062)3.79715095
70regulation of cell communication by electrical coupling (GO:0010649)3.77803126
71regulation of sulfur metabolic process (GO:0042762)3.76418326
72response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.75718082
73telomere maintenance via semi-conservative replication (GO:0032201)3.75572300
74ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.74074861
75acetyl-CoA metabolic process (GO:0006084)3.73687961
76fatty acid oxidation (GO:0019395)3.72909472
77double-strand break repair via nonhomologous end joining (GO:0006303)3.70789794
78non-recombinational repair (GO:0000726)3.70789794
79telomere maintenance via recombination (GO:0000722)3.69988607
80pore complex assembly (GO:0046931)3.68232538
81translesion synthesis (GO:0019985)3.68187882
82regulation of sarcomere organization (GO:0060297)3.67995766
83folic acid-containing compound biosynthetic process (GO:0009396)3.65998691
84cellular ketone body metabolic process (GO:0046950)3.65237132
85lipid oxidation (GO:0034440)3.63812856
86mitotic chromosome condensation (GO:0007076)3.62429913
87regulation of striated muscle contraction (GO:0006942)3.60708565
88mitotic recombination (GO:0006312)3.59889782
89heart contraction (GO:0060047)3.59035667
90heart process (GO:0003015)3.59035667
91short-chain fatty acid metabolic process (GO:0046459)3.57822816
92oxidative phosphorylation (GO:0006119)3.57691789
93muscle tissue morphogenesis (GO:0060415)3.57159537
94muscle hypertrophy (GO:0014896)3.54370873
95biotin metabolic process (GO:0006768)3.53433861
96V(D)J recombination (GO:0033151)3.49091640
97positive regulation of fatty acid oxidation (GO:0046321)3.48906771
98heart trabecula formation (GO:0060347)3.47378935
99regulation of membrane repolarization (GO:0060306)3.45594911
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.45469467
101sister chromatid segregation (GO:0000819)3.4463158
102positive regulation of fatty acid beta-oxidation (GO:0032000)3.43973565
103fatty acid homeostasis (GO:0055089)3.42072237
104dosage compensation (GO:0007549)3.41049904
105pseudouridine synthesis (GO:0001522)3.38912830
106meiotic chromosome segregation (GO:0045132)3.37761623
107formation of translation preinitiation complex (GO:0001731)3.37149112
1084-hydroxyproline metabolic process (GO:0019471)3.35234465
109monocarboxylic acid catabolic process (GO:0072329)3.34642850
110regulation of the force of heart contraction (GO:0002026)3.34030358
111DNA replication-dependent nucleosome organization (GO:0034723)3.32152436
112DNA replication-dependent nucleosome assembly (GO:0006335)3.32152436
113regulation of sister chromatid cohesion (GO:0007063)3.32139983
114cell communication by electrical coupling (GO:0010644)3.30266762
115DNA duplex unwinding (GO:0032508)3.29512743
116positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.28288625
117DNA geometric change (GO:0032392)3.25319852
118IMP biosynthetic process (GO:0006188)3.21405950
119actin filament-based movement (GO:0030048)3.19531885
120positive regulation of chromosome segregation (GO:0051984)3.19331511
121carnitine metabolic process (GO:0009437)3.19128564
122nucleobase biosynthetic process (GO:0046112)3.19100496
123DNA topological change (GO:0006265)3.17073545
124glycogen catabolic process (GO:0005980)3.16646395
125sister chromatid cohesion (GO:0007062)3.15321202
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.13593150
127L-phenylalanine metabolic process (GO:0006558)3.13593150
128mitotic sister chromatid segregation (GO:0000070)3.12429259
129IMP metabolic process (GO:0046040)3.10696064
130ketone body metabolic process (GO:1902224)3.10556212
131cardiac muscle adaptation (GO:0014887)3.10208356
132cardiac muscle hypertrophy in response to stress (GO:0014898)3.10208356
133muscle hypertrophy in response to stress (GO:0003299)3.10208356
134regulation of translational fidelity (GO:0006450)3.09998345
135cardiac muscle cell action potential involved in contraction (GO:0086002)3.09856791
136glyoxylate metabolic process (GO:0046487)3.09256733
137regulation of fatty acid beta-oxidation (GO:0031998)3.07982629
138cardiac muscle cell action potential (GO:0086001)3.07489685
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06824107
140somatic hypermutation of immunoglobulin genes (GO:0016446)3.06657265
141somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06657265
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03577065
143regulation of ATP catabolic process (GO:1903289)3.03434948
144regulation of ATPase activity (GO:0043462)3.03434948
145postreplication repair (GO:0006301)3.03065080
146maturation of 5.8S rRNA (GO:0000460)3.02296429
147DNA replication checkpoint (GO:0000076)3.01693359
148rRNA catabolic process (GO:0016075)3.01013659
149replication fork processing (GO:0031297)2.99924834
150protein localization to chromosome, centromeric region (GO:0071459)2.96237748
151regulation of RNA export from nucleus (GO:0046831)2.95670956
152replicative senescence (GO:0090399)2.95571498
153ribosome biogenesis (GO:0042254)2.94703284
154cytoplasmic mRNA processing body assembly (GO:0033962)2.92775876
155regulation of centrosome cycle (GO:0046605)2.92041310
156negative regulation of cell cycle G2/M phase transition (GO:1902750)2.91173115
157DNA conformation change (GO:0071103)2.90645907
158ribosome assembly (GO:0042255)2.90378430
159histone-serine phosphorylation (GO:0035404)2.89650706
160negative regulation of mRNA processing (GO:0050686)2.88629077
161somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85977496
162somatic cell DNA recombination (GO:0016444)2.85977496
163regulation of centriole replication (GO:0046599)2.84580626
164somatic diversification of immune receptors (GO:0002200)2.84509248
165regulation of DNA damage checkpoint (GO:2000001)2.83104136
166folic acid metabolic process (GO:0046655)2.82799223
167purine nucleobase biosynthetic process (GO:0009113)2.82457141
168DNA ligation (GO:0006266)2.80396487
169DNA-dependent DNA replication (GO:0006261)2.79945431
170telomere maintenance (GO:0000723)2.79875498
171monoubiquitinated protein deubiquitination (GO:0035520)2.79230608
172regulation of centrosome duplication (GO:0010824)2.77809456
173telomere organization (GO:0032200)2.76762594
174DNA synthesis involved in DNA repair (GO:0000731)2.74459675
175negative regulation of mRNA metabolic process (GO:1903312)2.73622192
176interkinetic nuclear migration (GO:0022027)2.72494648
177maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72128578
178alternative mRNA splicing, via spliceosome (GO:0000380)2.71868360
179positive regulation of histone H3-K4 methylation (GO:0051571)2.71640452
180peptidyl-threonine dephosphorylation (GO:0035970)2.70945551
181DNA biosynthetic process (GO:0071897)2.70421386
182maturation of SSU-rRNA (GO:0030490)2.69289899
183somatic diversification of immunoglobulins (GO:0016445)2.68200010
184mitochondrial RNA metabolic process (GO:0000959)2.68196481
185somatic recombination of immunoglobulin gene segments (GO:0016447)2.68179335
186DNA replication (GO:0006260)2.66737105
187mitotic nuclear envelope disassembly (GO:0007077)2.66392837
188telomere maintenance via telomere lengthening (GO:0010833)2.66085085
189glutamine metabolic process (GO:0006541)2.63889718
190regulation of nuclear cell cycle DNA replication (GO:0033262)2.63622919
191ribonucleoprotein complex biogenesis (GO:0022613)2.62688682
192ribosomal large subunit biogenesis (GO:0042273)2.61632131
193rRNA processing (GO:0006364)2.61477681
194positive regulation of cell cycle checkpoint (GO:1901978)2.60978541
195regulation of DNA-dependent DNA replication (GO:0090329)2.59422987
196double-strand break repair via homologous recombination (GO:0000724)2.58645713
197protein localization to kinetochore (GO:0034501)2.58110652
198protein K6-linked ubiquitination (GO:0085020)2.57290610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.47704839
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.11477518
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.59908885
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38767581
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32259618
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.24452192
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.93329803
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.85818788
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.82819357
10ZNF263_19887448_ChIP-Seq_K562_Human3.52213155
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.41460120
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.34431955
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20350232
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12550692
15E2F1_21310950_ChIP-Seq_MCF-7_Human3.02529782
16TBX20_22080862_ChIP-Seq_HEART_Mouse2.94422502
17TBX20_22328084_ChIP-Seq_HEART_Mouse2.94422502
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.90232039
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88221050
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73727969
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71361115
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64971750
23FUS_26573619_Chip-Seq_HEK293_Human2.49543336
24AR_21909140_ChIP-Seq_LNCAP_Human2.48618224
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29115290
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.25985915
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.18149343
28EWS_26573619_Chip-Seq_HEK293_Human2.15893859
29ELK1_19687146_ChIP-ChIP_HELA_Human2.14483748
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.13564725
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12577384
32VDR_23849224_ChIP-Seq_CD4+_Human2.04027460
33MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.03125923
34IGF1R_20145208_ChIP-Seq_DFB_Human2.02993994
35PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02129586
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01135463
37E2F7_22180533_ChIP-Seq_HELA_Human10.4597976
38CLOCK_20551151_ChIP-Seq_293T_Human1.99659599
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.99247316
40GATA1_22025678_ChIP-Seq_K562_Human1.99125092
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95895079
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.93626098
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90820102
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90496349
45KDM5A_27292631_Chip-Seq_BREAST_Human1.89751131
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.89375065
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.87978089
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87624065
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87057533
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.86588880
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85891068
52TTF2_22483619_ChIP-Seq_HELA_Human1.83528602
53MYC_18940864_ChIP-ChIP_HL60_Human1.81083341
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81077607
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.78361787
56GATA4_21415370_ChIP-Seq_HL-1_Mouse1.75901884
57FOXP3_21729870_ChIP-Seq_TREG_Human1.74140479
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70393683
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66705111
60* DCP1A_22483619_ChIP-Seq_HELA_Human1.65481406
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65394961
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64591811
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.64085543
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63042234
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61651590
66XRN2_22483619_ChIP-Seq_HELA_Human1.61483720
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54903042
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49973299
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49148189
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47028539
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45790889
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.44643348
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44455765
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43821873
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.42727849
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39300662
77MYC_22102868_ChIP-Seq_BL_Human1.38354929
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37697753
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36119623
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34141112
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31891718
82* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31569965
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30322404
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.29514276
85* GABP_19822575_ChIP-Seq_HepG2_Human1.29359678
86LXR_22292898_ChIP-Seq_THP-1_Human1.29112959
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28628366
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28517999
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28278073
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27834366
91CIITA_25753668_ChIP-Seq_RAJI_Human1.24056021
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.22172905
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21258521
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21125846
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20375410
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19115976
97ATF3_27146783_Chip-Seq_COLON_Human1.15289878
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14369476
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.13948090
100* P68_20966046_ChIP-Seq_HELA_Human1.13259299
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12181090
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11301556
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10148383
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09845861
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09569697
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09527004
107CTCF_27219007_Chip-Seq_Bcells_Human1.09362898
108RACK7_27058665_Chip-Seq_MCF-7_Human1.07978943
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07548400
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06954487
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06841440
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06578463
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02166082
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01479289
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01125910
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00858813
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.99985157
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99741804
119TP63_22573176_ChIP-Seq_HFKS_Human0.98506029
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.97560848
121ZNF274_21170338_ChIP-Seq_K562_Hela0.97451945
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97225924
123CREB1_26743006_Chip-Seq_LNCaP_Human0.97194558
124CHD1_26751641_Chip-Seq_LNCaP_Human0.96539726
125GATA1_19941826_ChIP-Seq_K562_Human0.95895746
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94695178
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94090330
128SMC4_20622854_ChIP-Seq_HELA_Human0.93895869
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93703946
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.92137699
131KDM2B_26808549_Chip-Seq_DND41_Human0.88718445
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88631589
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88424127
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88269862
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88013558
136* CTCF_21964334_Chip-Seq_Bcells_Human0.87673945
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86768593
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86626161
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86107228
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85658170
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84156761
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83974555
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83701966
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82773094
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82209687
146* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82203721
147* BCOR_27268052_Chip-Seq_Bcells_Human0.82128725
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81258432
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80661281
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80425669
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79384500
152CBP_20019798_ChIP-Seq_JUKART_Human0.79384500
153* OCT4_20526341_ChIP-Seq_ESCs_Human0.79247355
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78296370
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77351068
156TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77320651
157BP1_19119308_ChIP-ChIP_Hs578T_Human0.76699104
158BCL6_27268052_Chip-Seq_Bcells_Human0.75714316
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75686771
160* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75483685
161SPI1_20517297_ChIP-Seq_HL60_Human0.75467794
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75024203
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74873673
164FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74405602
165SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73841169
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73302374
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.73206592
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73004361
169ER_23166858_ChIP-Seq_MCF-7_Human0.72882391
170ELK3_25401928_ChIP-Seq_HUVEC_Human0.72301207
171NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71230673
172RAC3_21632823_ChIP-Seq_H3396_Human0.71070369
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70944274
174GATA3_24758297_ChIP-Seq_MCF-7_Human0.70646173
175SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70318378
176TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70158770
177VDR_22108803_ChIP-Seq_LS180_Human0.70067619
178PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69748859
179TP53_22573176_ChIP-Seq_HFKS_Human0.69531453
180CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69026811
181EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.68469199
182FOXH1_21741376_ChIP-Seq_ESCs_Human0.67977024
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.67718613
184ERG_21242973_ChIP-ChIP_JURKAT_Human0.67268296
185ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67201054
186GATA2_19941826_ChIP-Seq_K562_Human0.66011576
187RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64994948
188* FOXO3_23340844_ChIP-Seq_DLD1_Human0.64833791
189EGR1_19032775_ChIP-ChIP_M12_Human0.64550593
190SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64248003
191CEBPB_22108803_ChIP-Seq_LS180_Human0.63961763
192KLF4_19829295_ChIP-Seq_ESCs_Human0.62010391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.65390106
2MP0003646_muscle_fatigue5.45178812
3MP0008057_abnormal_DNA_replication4.58030264
4MP0000751_myopathy4.56931282
5MP0004084_abnormal_cardiac_muscle4.55726933
6MP0010094_abnormal_chromosome_stability4.47281040
7MP0004215_abnormal_myocardial_fiber4.16770885
8MP0002009_preneoplasia4.14632859
9MP0004036_abnormal_muscle_relaxation3.57707034
10MP0000749_muscle_degeneration3.55498917
11MP0005330_cardiomyopathy3.46512616
12MP0004130_abnormal_muscle_cell3.00611021
13MP0003693_abnormal_embryo_hatching2.98579147
14MP0003111_abnormal_nucleus_morphology2.92035085
15MP0008058_abnormal_DNA_repair2.81082320
16MP0004087_abnormal_muscle_fiber2.78621332
17MP0002396_abnormal_hematopoietic_system2.63880855
18MP0003077_abnormal_cell_cycle2.57253408
19MP0003137_abnormal_impulse_conducting2.55389245
20MP0003806_abnormal_nucleotide_metabolis2.54160292
21MP0005365_abnormal_bile_salt2.47585981
22MP0002269_muscular_atrophy2.47286360
23MP0002972_abnormal_cardiac_muscle2.41831930
24MP0009697_abnormal_copulation2.38130443
25MP0005085_abnormal_gallbladder_physiolo2.35175636
26MP0005620_abnormal_muscle_contractility2.34272569
27MP0002139_abnormal_hepatobiliary_system2.33821108
28MP0004145_abnormal_muscle_electrophysio2.33188159
29MP0008775_abnormal_heart_ventricle2.32311450
30MP0002877_abnormal_melanocyte_morpholog2.32092735
31MP0000750_abnormal_muscle_regeneration2.28574474
32MP0000747_muscle_weakness2.28391053
33MP0006036_abnormal_mitochondrial_physio2.22121873
34MP0002106_abnormal_muscle_physiology2.19203235
35MP0010630_abnormal_cardiac_muscle2.17479880
36MP0005385_cardiovascular_system_phenoty2.11792077
37MP0001544_abnormal_cardiovascular_syste2.11792077
38MP0004957_abnormal_blastocyst_morpholog2.05056716
39MP0006138_congestive_heart_failure2.01831969
40MP0002163_abnormal_gland_morphology1.91240587
41MP0005670_abnormal_white_adipose1.90763737
42MP0003221_abnormal_cardiomyocyte_apopto1.90279739
43MP0001188_hyperpigmentation1.88325121
44MP0000759_abnormal_skeletal_muscle1.88125444
45MP0001661_extended_life_span1.87300189
46MP0002166_altered_tumor_susceptibility1.84830289
47MP0005666_abnormal_adipose_tissue1.84825189
48MP0005360_urolithiasis1.83184310
49MP0003315_abnormal_perineum_morphology1.81595342
50MP0004085_abnormal_heartbeat1.80415427
51MP0004233_abnormal_muscle_weight1.78390948
52MP0005369_muscle_phenotype1.76731425
53MP0008007_abnormal_cellular_replicative1.73217440
54MP0005083_abnormal_biliary_tract1.72687061
55MP0004484_altered_response_of1.71567955
56MP0002006_tumorigenesis1.69539340
57MP0009379_abnormal_foot_pigmentation1.61703611
58MP0010307_abnormal_tumor_latency1.58016568
59MP0004808_abnormal_hematopoietic_stem1.55756908
60MP0003786_premature_aging1.50604699
61MP0002332_abnormal_exercise_endurance1.40961596
62MP0006035_abnormal_mitochondrial_morpho1.36680396
63MP0004185_abnormal_adipocyte_glucose1.36262084
64MP0000350_abnormal_cell_proliferation1.34518394
65MP0002160_abnormal_reproductive_system1.33912111
66MP0005645_abnormal_hypothalamus_physiol1.31954504
67MP0010352_gastrointestinal_tract_polyps1.31832063
68MP0001666_abnormal_nutrient_absorption1.30969952
69MP0003828_pulmonary_edema1.28524854
70MP0003705_abnormal_hypodermis_morpholog1.24614260
71MP0004043_abnormal_pH_regulation1.23516725
72MP0008932_abnormal_embryonic_tissue1.22050033
73MP0002127_abnormal_cardiovascular_syste1.21710620
74MP0000537_abnormal_urethra_morphology1.20098351
75MP0010329_abnormal_lipoprotein_level1.19698130
76MP0005332_abnormal_amino_acid1.19617160
77MP0005375_adipose_tissue_phenotype1.17623826
78MP0003252_abnormal_bile_duct1.15292427
79MP0005319_abnormal_enzyme/_coenzyme1.14722755
80MP0005266_abnormal_metabolism1.14047046
81MP0001697_abnormal_embryo_size1.13966053
82MP0003195_calcinosis1.11200566
83MP0002876_abnormal_thyroid_physiology1.10865083
84MP0003943_abnormal_hepatobiliary_system1.10748800
85MP0003283_abnormal_digestive_organ1.10357576
86MP0004134_abnormal_chest_morphology1.10232413
87MP0005379_endocrine/exocrine_gland_phen1.09661672
88MP0002234_abnormal_pharynx_morphology1.08112052
89MP0004197_abnormal_fetal_growth/weight/1.07480555
90MP0004510_myositis1.07228683
91MP0001672_abnormal_embryogenesis/_devel1.07225326
92MP0005380_embryogenesis_phenotype1.07225326
93MP0008877_abnormal_DNA_methylation1.06830994
94MP0000383_abnormal_hair_follicle1.04922265
95MP0002118_abnormal_lipid_homeostasis1.03511957
96MP0010678_abnormal_skin_adnexa1.00831276
97MP0008875_abnormal_xenobiotic_pharmacok1.00630783
98MP0002909_abnormal_adrenal_gland0.99342469
99MP0006072_abnormal_retinal_apoptosis0.98137403
100MP0002078_abnormal_glucose_homeostasis0.97033779
101MP0001730_embryonic_growth_arrest0.96247968
102MP0003656_abnormal_erythrocyte_physiolo0.95254429
103MP0009840_abnormal_foam_cell0.94912112
104MP0001873_stomach_inflammation0.92470336
105MP0003937_abnormal_limbs/digits/tail_de0.92118995
106MP0000631_abnormal_neuroendocrine_gland0.89346937
107MP0000266_abnormal_heart_morphology0.89152604
108MP0000313_abnormal_cell_death0.89046447
109MP0005389_reproductive_system_phenotype0.88265361
110MP0005187_abnormal_penis_morphology0.87964030
111MP0001944_abnormal_pancreas_morphology0.87260336
112MP0000733_abnormal_muscle_development0.86306227
113MP0005165_increased_susceptibility_to0.85073738
114MP0001145_abnormal_male_reproductive0.83213905
115MP0003763_abnormal_thymus_physiology0.82766423
116MP0003567_abnormal_fetal_cardiomyocyte0.82682575
117MP0002019_abnormal_tumor_incidence0.82623133
118MP0001270_distended_abdomen0.82068574
119MP0002084_abnormal_developmental_patter0.81951267
120MP0002210_abnormal_sex_determination0.81906311
121MP0000613_abnormal_salivary_gland0.78828336
122MP0002080_prenatal_lethality0.78790047
123MP0010368_abnormal_lymphatic_system0.78295360
124MP0001929_abnormal_gametogenesis0.77421609
125MP0000230_abnormal_systemic_arterial0.77119150
126MP0004147_increased_porphyrin_level0.77107269
127MP0002971_abnormal_brown_adipose0.76313529
128MP0000609_abnormal_liver_physiology0.75984838
129MP0000343_altered_response_to0.75432056
130MP0005584_abnormal_enzyme/coenzyme_acti0.74851143
131MP0008995_early_reproductive_senescence0.74522270
132MP0005174_abnormal_tail_pigmentation0.73458526
133MP0002108_abnormal_muscle_morphology0.73192757
134MP0000372_irregular_coat_pigmentation0.72943519
135MP0008961_abnormal_basal_metabolism0.72867780
136MP0001919_abnormal_reproductive_system0.72535720
137MP0001286_abnormal_eye_development0.72338862
138MP0000003_abnormal_adipose_tissue0.72230649
139MP0000703_abnormal_thymus_morphology0.71777496
140MP0000653_abnormal_sex_gland0.70855376
141MP0002086_abnormal_extraembryonic_tissu0.70354971
142MP0002928_abnormal_bile_duct0.70312408
143MP0003950_abnormal_plasma_membrane0.68475371
144MP0002085_abnormal_embryonic_tissue0.68462816
145MP0005076_abnormal_cell_differentiation0.66972835
146MP0005535_abnormal_body_temperature0.66176932
147MP0010234_abnormal_vibrissa_follicle0.63949495
148MP0003566_abnormal_cell_adhesion0.63310119
149MP0009780_abnormal_chondrocyte_physiolo0.61031434
150MP0000013_abnormal_adipose_tissue0.60902931
151MP0005334_abnormal_fat_pad0.60666527
152MP0002128_abnormal_blood_circulation0.58876339
153MP0005220_abnormal_exocrine_pancreas0.56294497
154MP0009643_abnormal_urine_homeostasis0.53932731
155MP0002822_catalepsy0.51053516
156MP0003868_abnormal_feces_composition0.48839926
157MP0003186_abnormal_redox_activity0.43945448
158MP0002970_abnormal_white_adipose0.43665370
159MP0005451_abnormal_body_composition0.43065593
160MP0005376_homeostasis/metabolism_phenot0.42924550
161MP0005647_abnormal_sex_gland0.39853888
162MP0005448_abnormal_energy_balance0.38147873
163MP0000598_abnormal_liver_morphology0.36481062
164MP0005452_abnormal_adipose_tissue0.35538917
165MP0003953_abnormal_hormone_level0.34941473
166MP0001764_abnormal_homeostasis0.33965054
167MP0003984_embryonic_growth_retardation0.33674821
168MP0002088_abnormal_embryonic_growth/wei0.33396228
169MP0009642_abnormal_blood_homeostasis0.33015298
170MP0000358_abnormal_cell_content/0.32828692

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.38260514
2Ventricular tachycardia (HP:0004756)5.74459079
3Exercise-induced myalgia (HP:0003738)5.63366578
4Calf muscle hypertrophy (HP:0008981)5.59184626
5Exercise-induced muscle cramps (HP:0003710)5.51631931
6Myoglobinuria (HP:0002913)5.30704195
7Muscle hypertrophy of the lower extremities (HP:0008968)5.20780906
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.71407589
9Muscle fiber splitting (HP:0003555)4.66001689
10Atrial fibrillation (HP:0005110)4.61327949
11Chromsome breakage (HP:0040012)4.53774121
12Right ventricular cardiomyopathy (HP:0011663)4.44895627
13Lipoatrophy (HP:0100578)4.33329557
14Hyporeflexia of lower limbs (HP:0002600)4.31776075
15Primary atrial arrhythmia (HP:0001692)4.28283013
16Abnormality of the calf musculature (HP:0001430)4.26551024
17Supraventricular tachycardia (HP:0004755)4.15489514
18Supraventricular arrhythmia (HP:0005115)4.06590928
19Rhabdomyolysis (HP:0003201)3.91964070
20Hypoglycemic coma (HP:0001325)3.89296747
21Bundle branch block (HP:0011710)3.89102583
22Palpitations (HP:0001962)3.88956926
23Subaortic stenosis (HP:0001682)3.86069636
24Abnormality of the left ventricular outflow tract (HP:0011103)3.86069636
25Ketoacidosis (HP:0001993)3.79492795
26Increased connective tissue (HP:0009025)3.72266095
27Dilated cardiomyopathy (HP:0001644)3.70657358
28Syncope (HP:0001279)3.66867422
29Difficulty running (HP:0009046)3.63710415
30Ketosis (HP:0001946)3.55924433
31EMG: myopathic abnormalities (HP:0003458)3.44371477
32Abnormality of fatty-acid metabolism (HP:0004359)3.44220567
33Asymmetric septal hypertrophy (HP:0001670)3.37945285
34Nemaline bodies (HP:0003798)3.28604536
35Ventricular arrhythmia (HP:0004308)3.21070464
36Heart block (HP:0012722)3.18562645
37Myotonia (HP:0002486)3.15276430
38B lymphocytopenia (HP:0010976)3.12841386
39Atrioventricular block (HP:0001678)3.12268324
40Prolonged QT interval (HP:0001657)3.09843448
41Hyperglycinuria (HP:0003108)3.08644434
42Volvulus (HP:0002580)3.05784508
43Abnormality of chromosome stability (HP:0003220)3.04982780
44Hyperammonemia (HP:0001987)3.03501399
45Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01367970
46Dicarboxylic aciduria (HP:0003215)3.01367970
47Abnormal atrioventricular conduction (HP:0005150)2.98673316
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91601375
49Hepatic necrosis (HP:0002605)2.89032344
50Distal arthrogryposis (HP:0005684)2.87816029
51Hyperinsulinemic hypoglycemia (HP:0000825)2.85355729
52Abnormality of B cell number (HP:0010975)2.83084468
53Abnormality of serine family amino acid metabolism (HP:0010894)2.81833318
54Abnormality of glycine metabolism (HP:0010895)2.81833318
55Severe combined immunodeficiency (HP:0004430)2.81205729
56Cerebral edema (HP:0002181)2.79250918
57Difficulty climbing stairs (HP:0003551)2.74559753
5811 pairs of ribs (HP:0000878)2.73336991
59Ventricular fibrillation (HP:0001663)2.70635796
60Acute lymphatic leukemia (HP:0006721)2.62434797
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.59128843
62Birth length less than 3rd percentile (HP:0003561)2.58610169
63Abnormality of the preputium (HP:0100587)2.58116657
64Muscle stiffness (HP:0003552)2.56798547
65Increased muscle lipid content (HP:0009058)2.56538429
66Muscle fiber inclusion bodies (HP:0100299)2.52733667
67Ragged-red muscle fibers (HP:0003200)2.52625405
68Progressive muscle weakness (HP:0003323)2.51855121
69Renal cortical cysts (HP:0000803)2.50496499
70Hypoalphalipoproteinemia (HP:0003233)2.49045236
71Hyperglycinemia (HP:0002154)2.47914349
72Abnormality of alanine metabolism (HP:0010916)2.46455778
73Hyperalaninemia (HP:0003348)2.46455778
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46455778
75Abnormal mitochondria in muscle tissue (HP:0008316)2.45719814
76Hypoplasia of the thymus (HP:0000778)2.44833285
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43114634
78Meckel diverticulum (HP:0002245)2.40586302
79Abnormality of the ileum (HP:0001549)2.39637708
80Abnormality of DNA repair (HP:0003254)2.37931255
81Acute encephalopathy (HP:0006846)2.36462455
82Abnormal finger flexion creases (HP:0006143)2.35412159
83Testicular atrophy (HP:0000029)2.31223301
84Absent phalangeal crease (HP:0006109)2.30030894
85Left ventricular hypertrophy (HP:0001712)2.28738982
86Abnormal EKG (HP:0003115)2.26935868
87Areflexia of lower limbs (HP:0002522)2.26666137
88Hepatocellular necrosis (HP:0001404)2.26065871
89Acute necrotizing encephalopathy (HP:0006965)2.25576664
90Limb-girdle muscle atrophy (HP:0003797)2.23223126
91Generalized aminoaciduria (HP:0002909)2.21912034
92Calcaneovalgus deformity (HP:0001848)2.21382813
93Unilateral renal agenesis (HP:0000122)2.21111940
94Lactic acidosis (HP:0003128)2.19595280
95Thyroiditis (HP:0100646)2.19034480
96Gout (HP:0001997)2.18348114
97Myelodysplasia (HP:0002863)2.18210678
98Hyperglycemia (HP:0003074)2.17084450
99Type 1 muscle fiber predominance (HP:0003803)2.16881354
100Increased intramyocellular lipid droplets (HP:0012240)2.16565222
101Combined immunodeficiency (HP:0005387)2.14596194
102Abnormality of the renal cortex (HP:0011035)2.14580845
103Skin nodule (HP:0200036)2.14460364
104Metabolic acidosis (HP:0001942)2.12940007
105Hypoplastic ischia (HP:0003175)2.11830830
106Palmoplantar keratoderma (HP:0000982)2.11378312
107Abnormality of chromosome segregation (HP:0002916)2.10151222
108Long clavicles (HP:0000890)2.09117430
109Septate vagina (HP:0001153)2.08613862
110Patellar aplasia (HP:0006443)2.08594799
111Acute myeloid leukemia (HP:0004808)2.08237732
112Distal lower limb muscle weakness (HP:0009053)2.08095355
113Cystic hygroma (HP:0000476)2.07348098
114Increased variability in muscle fiber diameter (HP:0003557)2.07259943
115Dysmetric saccades (HP:0000641)2.06990367
116Cholelithiasis (HP:0001081)2.06372659
117Aplasia/Hypoplasia of the patella (HP:0006498)2.04064543
118EMG: neuropathic changes (HP:0003445)2.03734015
119Proximal tubulopathy (HP:0000114)2.03374225
120Intrahepatic cholestasis (HP:0001406)2.02926567
121Ectopic kidney (HP:0000086)2.02175007
122Abnormality of the ischium (HP:0003174)1.99620822
123Sloping forehead (HP:0000340)1.98356834
124Abnormality of the calcaneus (HP:0008364)1.97874702
125Abnormality of the carotid arteries (HP:0005344)1.97501014
126Neck muscle weakness (HP:0000467)1.97282543
127Neoplasm of head and neck (HP:0012288)1.96923752
128Esophageal neoplasm (HP:0100751)1.96923752
129Deformed tarsal bones (HP:0008119)1.96662076
130Duplicated collecting system (HP:0000081)1.95200896
131Rimmed vacuoles (HP:0003805)1.95038423
132Large for gestational age (HP:0001520)1.93042355
133Increased CSF lactate (HP:0002490)1.92971107
134Lethargy (HP:0001254)1.92664652
135Clubbing of toes (HP:0100760)1.92044532
136Conjunctival hamartoma (HP:0100780)1.89855525
137Hypolipoproteinemia (HP:0010981)1.89651371
138Abnormality of serum amino acid levels (HP:0003112)1.89400583
139Pancreatic islet-cell hyperplasia (HP:0004510)1.88352128
140Abnormality of the renal collecting system (HP:0004742)1.87798555
141Abnormal gallbladder morphology (HP:0012437)1.87173602
142Abnormality of skeletal muscle fiber size (HP:0012084)1.86606180
143Fibular aplasia (HP:0002990)1.85722636
144Prominent nose (HP:0000448)1.85578609
145Absent thumb (HP:0009777)1.82870963
146Cerebellar dysplasia (HP:0007033)1.81973553
147Small intestinal stenosis (HP:0012848)1.79884583
148Duodenal stenosis (HP:0100867)1.79884583
149Missing ribs (HP:0000921)1.77145731
150Type II lissencephaly (HP:0007260)1.76925297
151Nephroblastoma (Wilms tumor) (HP:0002667)1.75536874
152Tachypnea (HP:0002789)1.75245671
153Short thumb (HP:0009778)1.74768798
154Abnormality of cells of the erythroid lineage (HP:0012130)1.74598189
155Partial agenesis of the corpus callosum (HP:0001338)1.74341358
156Reticulocytopenia (HP:0001896)1.68277783
157Hypoplastic iliac wings (HP:0002866)1.66802153
158Abnormal number of erythroid precursors (HP:0012131)1.66683586
159Cafe-au-lait spot (HP:0000957)1.65823405
160Hyperkalemia (HP:0002153)1.65795661
161Truncal obesity (HP:0001956)1.65145664
162Absent radius (HP:0003974)1.63719598
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.61155780
164Facial hemangioma (HP:0000329)1.60970515
165Pancreatic cysts (HP:0001737)1.60578702
166Glioma (HP:0009733)1.59911365
167Abnormality of the duodenum (HP:0002246)1.58256239
168Aplasia involving forearm bones (HP:0009822)1.57550946
169Absent forearm bone (HP:0003953)1.57550946
170Aplasia/Hypoplasia of the thymus (HP:0010515)1.56736720
171High pitched voice (HP:0001620)1.56651740
172Sandal gap (HP:0001852)1.56239485
173Abnormal biliary tract morphology (HP:0012440)1.56152771
174Metatarsus adductus (HP:0001840)1.55354203
175Panhypogammaglobulinemia (HP:0003139)1.54284055
176Hypoplasia of the pons (HP:0012110)1.53504772
177Triphalangeal thumb (HP:0001199)1.53461966
178Megaloblastic anemia (HP:0001889)1.53179699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54492016
2TTN5.08658550
3OBSCN4.07125965
4PHKG23.82308454
5PHKG13.82308454
6PDK33.62112874
7PDK43.62112874
8LMTK23.26705161
9CDC73.17047280
10FRK3.09517160
11TRIB33.09356239
12PNCK2.99074687
13PKN22.96997528
14NEK12.66313153
15PINK12.63442014
16SRPK12.53222159
17CDK122.37894933
18TAF12.30131346
19PDK22.17087088
20MYLK2.15313923
21SIK12.11922548
22DMPK2.09494567
23BUB12.01511684
24STK392.00431484
25WEE11.85853557
26MAP3K101.82210889
27PIK3CA1.78143998
28CHEK21.76902191
29MKNK11.67598777
30MKNK21.64301441
31INSRR1.63779410
32BRSK21.60576966
33ATR1.59066894
34EIF2AK31.49108043
35TSSK61.47704040
36NUAK11.45802575
37MUSK1.45766583
38BRD41.45049166
39SCYL21.43918117
40CDK81.40355547
41CAMK1G1.38981573
42FLT31.36945569
43TIE11.34032935
44TTK1.31442133
45MAP3K71.29049304
46TAOK31.28297183
47BMPR1B1.25908120
48STK241.24408473
49VRK11.19416723
50EIF2AK11.17962526
51ERBB31.16702595
52PASK1.16286637
53CDK71.16151667
54PLK41.13743366
55AURKB1.13492949
56MAPKAPK31.12645223
57RPS6KA41.11019036
58CHEK11.10518731
59PAK31.08448047
60NEK21.07809786
61CDK61.07195506
62PRKAA11.05375294
63GRK71.05110876
64PDGFRA1.02612964
65TLK11.02196430
66MAP2K31.01113441
67PLK11.00237938
68ATM0.99894460
69PRKD10.99876696
70MST1R0.99331413
71PBK0.97813957
72CAMK2D0.96786946
73MAP4K20.96569440
74EEF2K0.95271846
75CCNB10.94046946
76CDK30.92374497
77GRK10.90728754
78AKT30.89606718
79MAPK120.88338303
80STK30.87843564
81PLK30.86323109
82RIPK10.85906712
83CAMK40.85741328
84MAP3K30.84379352
85PRKAA20.78720572
86EIF2AK20.78616995
87ERN10.76111609
88VRK20.75650884
89PTK60.75141428
90MAPKAPK50.75033619
91CDK90.74212888
92ILK0.72436108
93IRAK10.72078339
94AURKA0.70185734
95MET0.69879449
96CDK20.68316227
97FGFR30.68293132
98LATS10.67900391
99FGFR40.67481149
100CDK10.66135679
101MAP3K50.64205842
102MAP2K40.63216741
103NLK0.63158435
104PDPK10.59334429
105ROCK10.57889833
106MAP3K140.57881104
107RPS6KA50.57720479
108SMG10.57218671
109STK38L0.57145900
110ZAK0.57129213
111CSNK1E0.56587785
112PDK10.56423688
113BRSK10.55831007
114CDC42BPA0.54446927
115WNK10.52984159
116ADRBK20.48380852
117MELK0.48140846
118AKT20.48059346
119MAP3K40.47601666
120PRKACG0.47390845
121WNK40.45452326
122MTOR0.44896073
123PRKACB0.44815549
124STK40.44479912
125NME10.44144136
126RPS6KA10.43115296
127CSNK2A20.43105671
128RET0.41246786
129NME20.40409907
130RPS6KC10.40193885
131RPS6KL10.40193885
132MAPK110.40172687
133CSNK1G10.39795973
134PIK3CG0.38975908
135PRKDC0.38491288
136TRPM70.38430113
137MAPK140.38378985
138CAMK10.37950534
139TGFBR20.37876647
140STK380.35280318
141JAK20.34352232
142CAMK2G0.34046753
143CAMK2A0.34012670
144ICK0.32075310
145PRKACA0.32059406
146PKN10.31474264
147RPS6KA60.30753643
148RPS6KA20.30735413
149FER0.30671188
150KDR0.30022363
151DAPK30.29378382
152FGFR10.27435250
153RPS6KB20.26769781
154PRKCH0.25819673
155RPS6KA30.24586559
156MARK30.23493992
157CAMK1D0.22362367
158TAOK20.22213142
159CDK40.22162480
160MAP2K60.22102413
161RPS6KB10.20376632
162LATS20.19889401
163PRKD30.18997842
164PRKCE0.16393649
165TAOK10.16335329
166DYRK1B0.15642360
167MAP3K110.15460537
168JAK10.15078104
169TGFBR10.14823176
170NEK90.14273365

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.10039591
2DNA replication_Homo sapiens_hsa030304.71754177
3Non-homologous end-joining_Homo sapiens_hsa034504.43501004
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.12153386
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.87565449
6Propanoate metabolism_Homo sapiens_hsa006403.71495821
7Fatty acid degradation_Homo sapiens_hsa000713.29601016
8Homologous recombination_Homo sapiens_hsa034403.25450999
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.19638241
10Mismatch repair_Homo sapiens_hsa034303.04779484
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03206075
12Fanconi anemia pathway_Homo sapiens_hsa034602.93770824
13Nucleotide excision repair_Homo sapiens_hsa034202.87781839
14RNA transport_Homo sapiens_hsa030132.61851797
15Carbon metabolism_Homo sapiens_hsa012002.55353224
16Cardiac muscle contraction_Homo sapiens_hsa042602.49470483
17Base excision repair_Homo sapiens_hsa034102.45486329
18Cell cycle_Homo sapiens_hsa041102.44770726
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44663945
20Fatty acid metabolism_Homo sapiens_hsa012122.40554013
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38480661
22Spliceosome_Homo sapiens_hsa030402.28507605
23Pyruvate metabolism_Homo sapiens_hsa006202.15325825
24Dilated cardiomyopathy_Homo sapiens_hsa054142.13292573
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.10623185
26RNA degradation_Homo sapiens_hsa030182.07496772
27Arginine biosynthesis_Homo sapiens_hsa002202.03797778
28Butanoate metabolism_Homo sapiens_hsa006502.02136148
29Tryptophan metabolism_Homo sapiens_hsa003801.95759801
30Pyrimidine metabolism_Homo sapiens_hsa002401.86874765
31Ribosome_Homo sapiens_hsa030101.73534528
32Biosynthesis of amino acids_Homo sapiens_hsa012301.71368790
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.71074471
34Nitrogen metabolism_Homo sapiens_hsa009101.69967326
35mRNA surveillance pathway_Homo sapiens_hsa030151.64291135
36Basal transcription factors_Homo sapiens_hsa030221.64018499
37PPAR signaling pathway_Homo sapiens_hsa033201.64001214
38Parkinsons disease_Homo sapiens_hsa050121.63656859
39RNA polymerase_Homo sapiens_hsa030201.61041275
40Starch and sucrose metabolism_Homo sapiens_hsa005001.50128592
41Oxidative phosphorylation_Homo sapiens_hsa001901.47808558
42beta-Alanine metabolism_Homo sapiens_hsa004101.45916891
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43847289
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42805917
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40358916
46Purine metabolism_Homo sapiens_hsa002301.38059091
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34955145
48Peroxisome_Homo sapiens_hsa041461.34117935
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31846404
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25931934
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22724605
52Fatty acid elongation_Homo sapiens_hsa000621.22582675
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22243263
54Alzheimers disease_Homo sapiens_hsa050101.21672634
55Arginine and proline metabolism_Homo sapiens_hsa003301.18369238
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17751988
57Insulin resistance_Homo sapiens_hsa049311.15010248
58Selenocompound metabolism_Homo sapiens_hsa004501.08680004
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07517721
60Fat digestion and absorption_Homo sapiens_hsa049751.04771505
61Glucagon signaling pathway_Homo sapiens_hsa049221.04000116
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03345329
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.01562480
64Phenylalanine metabolism_Homo sapiens_hsa003600.99790243
65Lysine degradation_Homo sapiens_hsa003100.99052456
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98570198
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.97367726
68Systemic lupus erythematosus_Homo sapiens_hsa053220.97120234
69Protein export_Homo sapiens_hsa030600.88457813
70Huntingtons disease_Homo sapiens_hsa050160.88314251
71Sulfur relay system_Homo sapiens_hsa041220.87837604
72Insulin signaling pathway_Homo sapiens_hsa049100.85822597
73N-Glycan biosynthesis_Homo sapiens_hsa005100.84577490
74p53 signaling pathway_Homo sapiens_hsa041150.84214768
75Fructose and mannose metabolism_Homo sapiens_hsa000510.80622416
76Alcoholism_Homo sapiens_hsa050340.80219785
77Bile secretion_Homo sapiens_hsa049760.78660856
78AMPK signaling pathway_Homo sapiens_hsa041520.77358676
79Sulfur metabolism_Homo sapiens_hsa009200.76103438
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74363070
81Viral myocarditis_Homo sapiens_hsa054160.73500187
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71699241
83Fatty acid biosynthesis_Homo sapiens_hsa000610.70829197
84Galactose metabolism_Homo sapiens_hsa000520.70811650
85Tyrosine metabolism_Homo sapiens_hsa003500.66599421
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66243000
87Viral carcinogenesis_Homo sapiens_hsa052030.64151817
88ABC transporters_Homo sapiens_hsa020100.63147567
89Non-small cell lung cancer_Homo sapiens_hsa052230.61815148
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57293764
91Glycerolipid metabolism_Homo sapiens_hsa005610.56952682
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56564280
93Complement and coagulation cascades_Homo sapiens_hsa046100.56262506
94Folate biosynthesis_Homo sapiens_hsa007900.55382333
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53897197
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.52870746
97FoxO signaling pathway_Homo sapiens_hsa040680.51873657
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50070299
99Type II diabetes mellitus_Homo sapiens_hsa049300.50051106
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49887612
101Pancreatic cancer_Homo sapiens_hsa052120.49737616
102Oocyte meiosis_Homo sapiens_hsa041140.49600495
103MicroRNAs in cancer_Homo sapiens_hsa052060.48802863
104Prostate cancer_Homo sapiens_hsa052150.48327269
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47800090
106Phototransduction_Homo sapiens_hsa047440.47775451
107Chronic myeloid leukemia_Homo sapiens_hsa052200.47753207
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46490282
109Bladder cancer_Homo sapiens_hsa052190.46108725
110Melanoma_Homo sapiens_hsa052180.45175875
111Ether lipid metabolism_Homo sapiens_hsa005650.45044224
112Pentose phosphate pathway_Homo sapiens_hsa000300.44300729
113Metabolic pathways_Homo sapiens_hsa011000.44091135
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.43740783
115Pancreatic secretion_Homo sapiens_hsa049720.42626913
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42494592
117Chemical carcinogenesis_Homo sapiens_hsa052040.40193670
118Small cell lung cancer_Homo sapiens_hsa052220.39625548
119Insulin secretion_Homo sapiens_hsa049110.39035237
120Thyroid cancer_Homo sapiens_hsa052160.37365273
121Hedgehog signaling pathway_Homo sapiens_hsa043400.36382685
122Calcium signaling pathway_Homo sapiens_hsa040200.35583081
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34218136
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33859493
125Linoleic acid metabolism_Homo sapiens_hsa005910.33426051
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33250034
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32706781
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31737883
129Thyroid hormone synthesis_Homo sapiens_hsa049180.31634030
130Primary immunodeficiency_Homo sapiens_hsa053400.30874190
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29522153
132One carbon pool by folate_Homo sapiens_hsa006700.29246028
133Basal cell carcinoma_Homo sapiens_hsa052170.27828986
134Dorso-ventral axis formation_Homo sapiens_hsa043200.27713883
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27072133
136Hippo signaling pathway_Homo sapiens_hsa043900.26472089
137Circadian rhythm_Homo sapiens_hsa047100.26201542
138mTOR signaling pathway_Homo sapiens_hsa041500.25837131
139Caffeine metabolism_Homo sapiens_hsa002320.25479347
140Long-term depression_Homo sapiens_hsa047300.25201360
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24884977
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24117642
143Herpes simplex infection_Homo sapiens_hsa051680.23358237
144Oxytocin signaling pathway_Homo sapiens_hsa049210.23039570
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.22563087
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.22431436
147Vitamin digestion and absorption_Homo sapiens_hsa049770.19938677
148Glioma_Homo sapiens_hsa052140.19915821
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19564180
150HTLV-I infection_Homo sapiens_hsa051660.19410936
151Histidine metabolism_Homo sapiens_hsa003400.18879110
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18232159
153HIF-1 signaling pathway_Homo sapiens_hsa040660.18072265
154Renin secretion_Homo sapiens_hsa049240.17422163
155Protein digestion and absorption_Homo sapiens_hsa049740.16956477
156Tight junction_Homo sapiens_hsa045300.15776862
157Focal adhesion_Homo sapiens_hsa045100.15475417
158Retinol metabolism_Homo sapiens_hsa008300.15154807
159Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12139481

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