PLVAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Notch signaling involved in heart development (GO:0061314)8.41139087
2lymph vessel development (GO:0001945)7.54609852
3ventricular trabecula myocardium morphogenesis (GO:0003222)7.00834188
4vascular endothelial growth factor signaling pathway (GO:0038084)6.93651658
5angiogenesis involved in wound healing (GO:0060055)6.77754559
6surfactant homeostasis (GO:0043129)6.60880158
7endothelium development (GO:0003158)5.97630332
8lymphangiogenesis (GO:0001946)5.97026163
9heart trabecula morphogenesis (GO:0061384)5.90870599
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.84488811
11blood vessel maturation (GO:0001955)5.59225052
12trabecula morphogenesis (GO:0061383)5.57303433
13retina vasculature morphogenesis in camera-type eye (GO:0061299)5.45104538
14positive regulation of vasculogenesis (GO:2001214)5.26983925
15morphogenesis of an endothelium (GO:0003159)5.24867840
16endothelial tube morphogenesis (GO:0061154)5.24867840
17ovulation from ovarian follicle (GO:0001542)5.23357534
18chemical homeostasis within a tissue (GO:0048875)5.10199499
19regulation of endothelial cell differentiation (GO:0045601)5.08623515
20endothelial cell morphogenesis (GO:0001886)4.95084002
21heart valve formation (GO:0003188)4.90480444
22glomerular filtration (GO:0003094)4.66424511
23renal filtration (GO:0097205)4.64185551
24blood vessel endothelial cell migration (GO:0043534)4.53968685
25basement membrane organization (GO:0071711)4.50083666
26cell migration involved in sprouting angiogenesis (GO:0002042)4.43944941
27labyrinthine layer development (GO:0060711)4.43866412
28regulation of vasculogenesis (GO:2001212)4.43671492
29negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.31879157
30patterning of blood vessels (GO:0001569)4.17525908
31vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.08818164
32endothelial cell differentiation (GO:0045446)4.07491846
33response to mercury ion (GO:0046689)4.02951476
34negative regulation of blood vessel endothelial cell migration (GO:0043537)3.85254300
35peptidyl-tyrosine autophosphorylation (GO:0038083)3.74254581
36regulation of blood vessel endothelial cell migration (GO:0043535)3.73944842
37aorta morphogenesis (GO:0035909)3.73555076
38venous blood vessel morphogenesis (GO:0048845)3.70683423
39cell surface receptor signaling pathway involved in heart development (GO:0061311)3.70186678
40transcytosis (GO:0045056)3.66700018
41renal absorption (GO:0070293)3.65604296
42positive regulation of lipid kinase activity (GO:0090218)3.64841160
43Notch receptor processing (GO:0007220)3.61371725
44positive regulation of endothelial cell differentiation (GO:0045603)3.60251809
45endocardial cushion morphogenesis (GO:0003203)3.58518519
46positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.58165264
47regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.52113786
48trabecula formation (GO:0060343)3.48283696
49negative regulation of vasculature development (GO:1901343)3.46735392
50definitive hemopoiesis (GO:0060216)3.46128745
51negative regulation of endothelial cell apoptotic process (GO:2000352)3.40536066
52regulation of establishment or maintenance of cell polarity (GO:0032878)3.40488741
53negative regulation of endothelial cell migration (GO:0010596)3.40378393
54positive regulation of protein kinase C signaling (GO:0090037)3.40350555
55endothelial cell migration (GO:0043542)3.40340888
56thrombin receptor signaling pathway (GO:0070493)3.39390633
57vasculogenesis (GO:0001570)3.35498374
58epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.27745756
59sprouting angiogenesis (GO:0002040)3.23536281
60regulation of vascular permeability (GO:0043114)3.22444514
61nephron epithelium development (GO:0072009)3.20984771
62adhesion of symbiont to host (GO:0044406)3.16503831
63protein localization to endosome (GO:0036010)3.15929779
64gland morphogenesis (GO:0022612)3.15458262
65protein maturation by protein folding (GO:0022417)3.14366373
66regulation of cell-substrate junction assembly (GO:0090109)3.12990518
67regulation of focal adhesion assembly (GO:0051893)3.12990518
68negative regulation of fibrinolysis (GO:0051918)3.12233759
69ovulation (GO:0030728)3.11229032
70regulation of adherens junction organization (GO:1903391)3.09900755
71heart trabecula formation (GO:0060347)3.09639607
72metanephric nephron epithelium development (GO:0072243)3.06942811
73endothelial cell chemotaxis (GO:0035767)3.05118311
74cellular response to nitric oxide (GO:0071732)3.02174945
75arginine catabolic process (GO:0006527)3.02160627
76embryonic heart tube development (GO:0035050)2.99504804
77mRNA transcription from RNA polymerase II promoter (GO:0042789)2.99314727
78SMAD protein complex assembly (GO:0007183)2.97744360
79regulation of phospholipid biosynthetic process (GO:0071071)2.94965750
80positive regulation of digestive system process (GO:0060456)2.93317354
81lysine metabolic process (GO:0006553)2.93264193
82lysine catabolic process (GO:0006554)2.93264193
83neuron remodeling (GO:0016322)2.91822891
84positive regulation of cell junction assembly (GO:1901890)2.90923763
85positive regulation of focal adhesion assembly (GO:0051894)2.90923763
86hyaluronan catabolic process (GO:0030214)2.90704169
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.87947150
88axon extension involved in axon guidance (GO:0048846)2.87947150
89renal tubule morphogenesis (GO:0061333)2.87675224
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.87087901
91L-phenylalanine catabolic process (GO:0006559)2.87087901
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86859687
93L-phenylalanine metabolic process (GO:0006558)2.86859687
94bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84805692
95wound healing, spreading of epidermal cells (GO:0035313)2.84797574
96negative regulation of platelet activation (GO:0010544)2.84678247
97positive regulation of actin cytoskeleton reorganization (GO:2000251)2.84042556
98endothelial cell proliferation (GO:0001935)2.82317456
99blood vessel morphogenesis (GO:0048514)2.82038292
100metanephric tubule development (GO:0072170)2.81541061
101metanephric nephron tubule development (GO:0072234)2.81541061
102positive regulation of adherens junction organization (GO:1903393)2.80857862
103regulation of angiogenesis (GO:0045765)2.80111670
104low-density lipoprotein particle clearance (GO:0034383)2.79998642
105positive regulation of endothelial cell migration (GO:0010595)2.79347891
106cell volume homeostasis (GO:0006884)2.78927594
107* protein kinase C signaling (GO:0070528)2.77719400
108gap junction assembly (GO:0016264)2.77619287
109regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.76450316
110cardiac ventricle morphogenesis (GO:0003208)2.76446462
111metanephric epithelium development (GO:0072207)2.75786406
112type B pancreatic cell proliferation (GO:0044342)2.75745561
113semaphorin-plexin signaling pathway (GO:0071526)2.74787125
114negative regulation of adherens junction organization (GO:1903392)2.74080567
115negative regulation of focal adhesion assembly (GO:0051895)2.74080567
116negative regulation of cell junction assembly (GO:1901889)2.74080567
117regulation of endothelial cell migration (GO:0010594)2.73734322
118regulation of vasculature development (GO:1901342)2.73391761
119embryonic hemopoiesis (GO:0035162)2.72858961
120establishment of endothelial barrier (GO:0061028)2.72679544
121regulation of endothelial cell apoptotic process (GO:2000351)2.72202131
122hormone catabolic process (GO:0042447)2.72186212
123polyol transport (GO:0015791)2.71982065
124regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.71862797
125cell migration involved in heart development (GO:0060973)2.71441459
126blood vessel remodeling (GO:0001974)2.71132596
127urate metabolic process (GO:0046415)2.70281038
128negative regulation of protein autophosphorylation (GO:0031953)2.68266814
129negative regulation of epithelial cell migration (GO:0010633)2.68141113
130negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.65326960
131ganglion development (GO:0061548)2.64851965
132high-density lipoprotein particle remodeling (GO:0034375)2.64409349
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64191674
134positive regulation of endothelial cell proliferation (GO:0001938)2.58938536
135negative regulation of blood vessel morphogenesis (GO:2000181)2.58916640
136drug transmembrane transport (GO:0006855)2.58735787
137exocrine pancreas development (GO:0031017)2.58705360
138negative regulation of angiogenesis (GO:0016525)2.58669988
139drug catabolic process (GO:0042737)2.58470996
140negative regulation of Rho protein signal transduction (GO:0035024)2.56216176
141regulation of fibrinolysis (GO:0051917)2.54852456
142angiogenesis (GO:0001525)2.54780807
143cAMP biosynthetic process (GO:0006171)2.53854998
144negative regulation of endothelial cell proliferation (GO:0001937)2.53406269
145positive regulation of hormone biosynthetic process (GO:0046886)2.51348548
146epithelial cell migration (GO:0010631)2.51250203
147arginine metabolic process (GO:0006525)2.50377570
148peptidyl-glutamic acid carboxylation (GO:0017187)2.50304593
149protein carboxylation (GO:0018214)2.50304593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67474123
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.53799900
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47673531
4CLOCK_20551151_ChIP-Seq_293T_Human3.88167474
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.61490758
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.49773844
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.16906255
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.05610004
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01893060
10* GATA2_21666600_ChIP-Seq_HMVEC_Human2.88519316
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.85184624
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.65444618
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44782658
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.24251038
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.17858386
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15213733
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14059842
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10934549
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.10049564
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09563889
21ZNF263_19887448_ChIP-Seq_K562_Human1.87838508
22GATA1_22025678_ChIP-Seq_K562_Human1.83489031
23SCL_19346495_ChIP-Seq_HPC-7_Human1.74397121
24* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69890403
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69579511
26GATA1_19941826_ChIP-Seq_K562_Human1.67623299
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67191505
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67191505
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67191505
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66588653
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55531628
32LXR_22292898_ChIP-Seq_THP-1_Human1.52948235
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47157573
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46801085
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.46761238
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.46761238
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.45974599
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.45128478
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39261501
40RACK7_27058665_Chip-Seq_MCF-7_Human1.36605560
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32495326
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29761166
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29177840
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28966283
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28139967
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27752693
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.25996477
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24974589
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24527252
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23268658
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23152044
52KDM2B_26808549_Chip-Seq_K562_Human1.22904548
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22817297
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22067906
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20963020
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17711562
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17080950
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15266423
59TCF7_22412390_ChIP-Seq_EML_Mouse1.13910931
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12354770
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11810481
62SOX2_20726797_ChIP-Seq_SW620_Human1.10819788
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10155605
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10043261
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09294773
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.08714218
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07688152
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07246076
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07168429
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04896571
71* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03053875
72SPI1_23127762_ChIP-Seq_K562_Human1.02844218
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.02206647
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02190932
75CJUN_26792858_Chip-Seq_BT549_Human1.01685196
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99311449
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97723768
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97465782
79KDM2B_26808549_Chip-Seq_DND41_Human0.97315134
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97310422
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97158831
82ERG_21242973_ChIP-ChIP_JURKAT_Human0.96609350
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96456345
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96446919
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95685943
86CTCF_27219007_Chip-Seq_Bcells_Human0.95518767
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.94741252
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93258363
89GATA2_19941826_ChIP-Seq_K562_Human0.92494592
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.91691275
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.91274768
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90458958
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90207501
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.89960471
95SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89909429
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89724004
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88931840
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88337462
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88109422
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87884199
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87675347
102GATA4_25053715_ChIP-Seq_YYC3_Human0.87083602
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87024349
104RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87017722
105EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87017722
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86994218
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86826144
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86620304
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86506219
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86134331
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85781839
112* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84959169
113* EZH2_27294783_Chip-Seq_ESCs_Mouse0.83692165
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83688089
115RING1B_27294783_Chip-Seq_ESCs_Mouse0.83422244
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83340377
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83298449
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82770024
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82289658
120* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82260582
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81926390
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80149548
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80120113
124* TET1_21490601_ChIP-Seq_MESCs_Mouse0.79862905
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.79836975
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79702264
127AHR_22903824_ChIP-Seq_MCF-7_Human0.79671722
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.78619828
129EGR1_19032775_ChIP-ChIP_M12_Human0.78335255
130NCOR1_26117541_ChIP-Seq_K562_Human0.77461443
131* DROSHA_22980978_ChIP-Seq_HELA_Human0.76572764
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76332036
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75095678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system8.94246485
2MP0001879_abnormal_lymphatic_vessel5.88052592
3MP0005167_abnormal_blood-brain_barrier5.07431556
4MP0004272_abnormal_basement_membrane4.93887664
5MP0003724_increased_susceptibility_to3.58397877
6MP0002138_abnormal_hepatobiliary_system3.10160096
7MP0005360_urolithiasis2.80157716
8MP0002139_abnormal_hepatobiliary_system2.52265036
9MP0004084_abnormal_cardiac_muscle2.47013581
10MP0003828_pulmonary_edema2.41747601
11MP0006054_spinal_hemorrhage2.09329037
12MP0000013_abnormal_adipose_tissue1.98557563
13MP0003705_abnormal_hypodermis_morpholog1.95011449
14MP0005365_abnormal_bile_salt1.94914595
15MP0005085_abnormal_gallbladder_physiolo1.90022765
16MP0003300_gastrointestinal_ulcer1.89341266
17MP0008875_abnormal_xenobiotic_pharmacok1.81511012
18MP0003191_abnormal_cellular_cholesterol1.73403070
19MP0003303_peritoneal_inflammation1.67366230
20MP0005409_darkened_coat_color1.66513139
21MP0005165_increased_susceptibility_to1.65676718
22MP0003566_abnormal_cell_adhesion1.65317777
23MP0000767_abnormal_smooth_muscle1.58182154
24MP0004782_abnormal_surfactant_physiolog1.51833071
25MP0003252_abnormal_bile_duct1.47105483
26MP0006138_congestive_heart_failure1.46752654
27MP0008004_abnormal_stomach_pH1.43861932
28MP0004036_abnormal_muscle_relaxation1.43255914
29MP0001756_abnormal_urination1.43157903
30MP0002933_joint_inflammation1.40074422
31MP0000249_abnormal_blood_vessel1.35606114
32MP0005595_abnormal_vascular_smooth1.35247108
33MP0009643_abnormal_urine_homeostasis1.34744161
34MP0001958_emphysema1.34600737
35MP0010329_abnormal_lipoprotein_level1.30439344
36MP0005058_abnormal_lysosome_morphology1.30269611
37MP0003279_aneurysm1.24553703
38MP0000751_myopathy1.21400464
39MP0004510_myositis1.15536452
40MP0002295_abnormal_pulmonary_circulatio1.15209756
41MP0001851_eye_inflammation1.13980931
42MP0001849_ear_inflammation1.10218394
43MP0000465_gastrointestinal_hemorrhage1.09675861
44MP0002128_abnormal_blood_circulation1.09624203
45MP0005332_abnormal_amino_acid1.08693285
46MP0004019_abnormal_vitamin_homeostasis1.07326234
47MP0008775_abnormal_heart_ventricle1.05563054
48MP0002925_abnormal_cardiovascular_devel1.05478011
49MP0001614_abnormal_blood_vessel1.02703058
50MP0003868_abnormal_feces_composition1.01528453
51MP0004883_abnormal_blood_vessel0.99941849
52MP0002332_abnormal_exercise_endurance0.99142765
53MP0005164_abnormal_response_to0.98059505
54MP0000343_altered_response_to0.97132214
55MP0002877_abnormal_melanocyte_morpholog0.96790874
56MP0004215_abnormal_myocardial_fiber0.95735737
57MP0004264_abnormal_extraembryonic_tissu0.94830953
58MP0005319_abnormal_enzyme/_coenzyme0.94366707
59MP0001915_intracranial_hemorrhage0.93053182
60MP0000230_abnormal_systemic_arterial0.91987959
61MP0005385_cardiovascular_system_phenoty0.91174245
62MP0001544_abnormal_cardiovascular_syste0.91174245
63MP0009840_abnormal_foam_cell0.88964787
64MP0000609_abnormal_liver_physiology0.87925502
65MP0009278_abnormal_bone_marrow0.85428394
66MP0004085_abnormal_heartbeat0.85239457
67MP0005083_abnormal_biliary_tract0.84964533
68MP0008438_abnormal_cutaneous_collagen0.82632693
69MP0003195_calcinosis0.82558852
70MP0003075_altered_response_to0.79418099
71MP0005375_adipose_tissue_phenotype0.78580740
72MP0001765_abnormal_ion_homeostasis0.78264897
73MP0004043_abnormal_pH_regulation0.77898017
74MP0001666_abnormal_nutrient_absorption0.77088316
75MP0008961_abnormal_basal_metabolism0.76833910
76MP0000003_abnormal_adipose_tissue0.76510643
77MP0002136_abnormal_kidney_physiology0.74979212
78MP0009053_abnormal_anal_canal0.74532510
79MP0002796_impaired_skin_barrier0.73789577
80MP0002118_abnormal_lipid_homeostasis0.73530952
81MP0002127_abnormal_cardiovascular_syste0.72869064
82MP0010234_abnormal_vibrissa_follicle0.72092372
83MP0002086_abnormal_extraembryonic_tissu0.71604705
84MP0002088_abnormal_embryonic_growth/wei0.70278128
85MP0003984_embryonic_growth_retardation0.69979421
86MP0009697_abnormal_copulation0.69323788
87MP0006082_CNS_inflammation0.69080667
88MP0009764_decreased_sensitivity_to0.68835045
89MP0002133_abnormal_respiratory_system0.68775536
90MP0005388_respiratory_system_phenotype0.68775536
91MP0002896_abnormal_bone_mineralization0.68699815
92MP0003122_maternal_imprinting0.68234063
93MP0001784_abnormal_fluid_regulation0.68194206
94MP0010155_abnormal_intestine_physiology0.66800053
95MP0000598_abnormal_liver_morphology0.65830095
96MP0000266_abnormal_heart_morphology0.65782600
97MP0003172_abnormal_lysosome_physiology0.65615041
98MP0003638_abnormal_response/metabolism_0.65390811
99MP0005084_abnormal_gallbladder_morpholo0.65169440
100MP0004484_altered_response_of0.64686223
101MP0000750_abnormal_muscle_regeneration0.64495555
102MP0005330_cardiomyopathy0.63878746
103MP0003091_abnormal_cell_migration0.63059964
104MP0005187_abnormal_penis_morphology0.62958806
105MP0000534_abnormal_ureter_morphology0.62867889
106MP0005275_abnormal_skin_tensile0.62507991
107MP0003943_abnormal_hepatobiliary_system0.62034706
108MP0003567_abnormal_fetal_cardiomyocyte0.61332179
109MP0000537_abnormal_urethra_morphology0.60943995
110MP0004130_abnormal_muscle_cell0.60870791
111MP0010630_abnormal_cardiac_muscle0.60686418
112MP0001663_abnormal_digestive_system0.59571913
113MP0005464_abnormal_platelet_physiology0.57825951
114MP0005636_abnormal_mineral_homeostasis0.56118917
115MP0001533_abnormal_skeleton_physiology0.56071003
116MP0005623_abnormal_meninges_morphology0.54526271
117MP0003948_abnormal_gas_homeostasis0.53568445
118MP0005670_abnormal_white_adipose0.52987698
119MP0003283_abnormal_digestive_organ0.52502520
120MP0005451_abnormal_body_composition0.50568453
121MP0001672_abnormal_embryogenesis/_devel0.50150581
122MP0005380_embryogenesis_phenotype0.50150581
123MP0002972_abnormal_cardiac_muscle0.49458125
124MP0004858_abnormal_nervous_system0.45962278
125MP0005193_abnormal_anterior_eye0.45037335
126MP0004885_abnormal_endolymph0.44118122
127MP0003866_abnormal_defecation0.42948055
128MP0002697_abnormal_eye_size0.42558496
129MP0001175_abnormal_lung_morphology0.39234379
130MP0005381_digestive/alimentary_phenotyp0.39186078
131MP0001545_abnormal_hematopoietic_system0.38538581
132MP0005397_hematopoietic_system_phenotyp0.38538581
133MP0000747_muscle_weakness0.38110558
134MP0005620_abnormal_muscle_contractility0.37711043
135MP0005501_abnormal_skin_physiology0.36988356
136MP0005666_abnormal_adipose_tissue0.36138898
137MP0004087_abnormal_muscle_fiber0.34718715

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.67845167
2Spontaneous hematomas (HP:0007420)5.67098885
3Hematochezia (HP:0002573)5.59545054
4Esophageal varix (HP:0002040)5.22005666
5Deep venous thrombosis (HP:0002625)4.69334258
6Limb dystonia (HP:0002451)4.60971512
7Nonimmune hydrops fetalis (HP:0001790)4.52822852
8Exotropia (HP:0000577)4.44789429
9Cerebral aneurysm (HP:0004944)4.25064456
10Cerebral hemorrhage (HP:0001342)4.22604061
11Abnormality of the nasal mucosa (HP:0000433)4.20436452
12Conjunctival telangiectasia (HP:0000524)4.04265122
13Scotoma (HP:0000575)3.89399322
14Arterial tortuosity (HP:0005116)3.89385608
15Lymphangioma (HP:0100764)3.82076766
16Joint hemorrhage (HP:0005261)3.77670832
17Hemorrhage of the eye (HP:0011885)3.75333424
18Hyperactive renin-angiotensin system (HP:0000841)3.68348491
19Visceral angiomatosis (HP:0100761)3.65058756
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.52722166
21Amblyopia (HP:0000646)3.52097201
22Vascular tortuosity (HP:0004948)3.51923385
23Abnormality of the intrinsic pathway (HP:0010989)3.42275810
24Hemangiomatosis (HP:0007461)3.39733227
25Wrist flexion contracture (HP:0001239)3.30528548
26Abnormality of skeletal muscle fiber size (HP:0012084)3.16686421
27Difficulty running (HP:0009046)3.11452195
28Hypokalemic alkalosis (HP:0001949)3.10837324
29Increased variability in muscle fiber diameter (HP:0003557)3.03460769
30Hemiplegia (HP:0002301)3.02973351
31Gout (HP:0001997)2.98217353
32Broad metatarsal (HP:0001783)2.97231659
33Cavernous hemangioma (HP:0001048)2.92427511
34Aneurysm (HP:0002617)2.78271675
35Premature rupture of membranes (HP:0001788)2.76925743
36Porencephaly (HP:0002132)2.75058258
37Stroke (HP:0001297)2.72818027
38Portal hypertension (HP:0001409)2.70630408
39Intrahepatic cholestasis (HP:0001406)2.66080167
40Cardiovascular calcification (HP:0011915)2.64419154
41Renal salt wasting (HP:0000127)2.63431604
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.62533460
43Protrusio acetabuli (HP:0003179)2.62175195
44Supraventricular arrhythmia (HP:0005115)2.61002770
45Vascular calcification (HP:0004934)2.60722138
46Hemiparesis (HP:0001269)2.58604240
47Abnormality of chloride homeostasis (HP:0011422)2.57100217
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56998125
49Hypopigmentation of the fundus (HP:0007894)2.56878496
50Systemic lupus erythematosus (HP:0002725)2.56683260
51Xanthomatosis (HP:0000991)2.55562477
52Difficulty climbing stairs (HP:0003551)2.51289261
53Asymmetry of the thorax (HP:0001555)2.50468980
54Hypoglycemic coma (HP:0001325)2.48238522
55Ketoacidosis (HP:0001993)2.43128810
56Tetraparesis (HP:0002273)2.42358294
57Delayed CNS myelination (HP:0002188)2.42118711
58Increased circulating renin level (HP:0000848)2.41598581
59Chondrocalcinosis (HP:0000934)2.40990860
60Increased connective tissue (HP:0009025)2.40786503
61Complement deficiency (HP:0004431)2.40573813
62Striae distensae (HP:0001065)2.37257225
63Abnormality of the hepatic vasculature (HP:0006707)2.37173863
64Right ventricular cardiomyopathy (HP:0011663)2.37025396
65Muscle fiber splitting (HP:0003555)2.34568655
66Capillary hemangiomas (HP:0005306)2.31254102
67Abnormality of renin-angiotensin system (HP:0000847)2.30735659
68Abnormality of purine metabolism (HP:0004352)2.29862475
69Metabolic alkalosis (HP:0200114)2.29821121
70Mucosal telangiectasiae (HP:0100579)2.29683576
71Neonatal death (HP:0003811)2.29337199
72Aortic dissection (HP:0002647)2.28271024
73Facial shape deformation (HP:0011334)2.26748066
74Potter facies (HP:0002009)2.26748066
75Hyperaldosteronism (HP:0000859)2.26607673
76Ketosis (HP:0001946)2.25814053
77Absent hand (HP:0004050)2.25290696
78Alkalosis (HP:0001948)2.24190451
79Skull defect (HP:0001362)2.24053757
80Menorrhagia (HP:0000132)2.21216844
81Abnormal platelet function (HP:0011869)2.20607374
82Impaired platelet aggregation (HP:0003540)2.20607374
83Abnormality of Sharpey fibers (HP:0100685)2.19954164
84Nephrolithiasis (HP:0000787)2.19242347
85J-shaped sella turcica (HP:0002680)2.19145950
86Thrombophlebitis (HP:0004418)2.18818200
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18555587
88Abnormality of the vitreous humor (HP:0004327)2.17895421
89Abnormality of renal excretion (HP:0011036)2.16112903
90Round ear (HP:0100830)2.15964908
91Venous insufficiency (HP:0005293)2.15638982
92Congenital cataract (HP:0000519)2.14063586
93Microcytic anemia (HP:0001935)2.13095784
94Pulmonary embolism (HP:0002204)2.10063529
95Interstitial pulmonary disease (HP:0006530)2.09882266
96Distal lower limb muscle weakness (HP:0009053)2.09745496
97Aortic aneurysm (HP:0004942)2.08493786
98Adactyly (HP:0009776)2.05961052
99Abnormal urine output (HP:0012590)2.05438759
100Hypoplasia of the iris (HP:0007676)2.03856280
101Abnormality of the common coagulation pathway (HP:0010990)2.02046582
102Spinal rigidity (HP:0003306)2.01451137
103Cerebral ischemia (HP:0002637)1.99851382
104Vertebral compression fractures (HP:0002953)1.99605966
105Mitral valve prolapse (HP:0001634)1.97953229
106Venous abnormality (HP:0002624)1.97767547
107Dysostosis multiplex (HP:0000943)1.96929260
108Hyperuricemia (HP:0002149)1.96925456
109Increased purine levels (HP:0004368)1.96925456
110Blue sclerae (HP:0000592)1.96876032
111Pigmentary retinal degeneration (HP:0001146)1.95590775
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.94880540
113Hyperglycinuria (HP:0003108)1.94857956
114Abnormality of the periventricular white matter (HP:0002518)1.94570005
115Back pain (HP:0003418)1.94523097
116Distal lower limb amyotrophy (HP:0008944)1.93644510
117Hypoalphalipoproteinemia (HP:0003233)1.92732166
118Prolonged partial thromboplastin time (HP:0003645)1.90735816
119Abnormality of complement system (HP:0005339)1.90572245
120Disproportionate tall stature (HP:0001519)1.88322345
121Myocardial infarction (HP:0001658)1.87831723
122Mesangial abnormality (HP:0001966)1.87613070
123Hyperlipoproteinemia (HP:0010980)1.85044973
124Hypoglycemic seizures (HP:0002173)1.84304171
125Autoimmune thrombocytopenia (HP:0001973)1.81813415
126Pulmonary hypertension (HP:0002092)1.80424581
127Hyperammonemia (HP:0001987)1.79962159
128Shallow orbits (HP:0000586)1.78789619
129Growth hormone excess (HP:0000845)1.78335392
130Amyloidosis (HP:0011034)1.77944223
131Short hallux (HP:0010109)1.77716831
132Hyporeflexia of lower limbs (HP:0002600)1.77247776
133Hepatocellular carcinoma (HP:0001402)1.75745295
134Polygenic inheritance (HP:0010982)1.74341262
135Lymphedema (HP:0001004)1.74058116
136Hydroureter (HP:0000072)1.72874703
137Nuclear cataract (HP:0100018)1.72084293
138Mitral stenosis (HP:0001718)1.69650378
139Intestinal polyposis (HP:0200008)1.69381035
140Ectopia lentis (HP:0001083)1.68057293
141Hypokalemia (HP:0002900)1.67681019
142Abnormality of fatty-acid metabolism (HP:0004359)1.67048651
143Atrioventricular block (HP:0001678)1.66349552
144Axonal loss (HP:0003447)1.66009779
145Nephritis (HP:0000123)1.64154694
146Glomerulonephritis (HP:0000099)1.63337574
147Skin nodule (HP:0200036)1.62902887
148Myotonia (HP:0002486)1.61791859
149Increased CSF protein (HP:0002922)1.60695495
150Hematuria (HP:0000790)1.59551760
151Broad face (HP:0000283)1.58736819
152Abnormality of the peritoneum (HP:0002585)1.58353357
153Joint stiffness (HP:0001387)1.57557514
154Cerebral palsy (HP:0100021)1.55741042
155Dilatation of the ascending aorta (HP:0005111)1.54200899
156High pitched voice (HP:0001620)1.51158731
157Abnormal vertebral ossification (HP:0100569)1.45635557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.79822543
2TGFBR23.91067128
3TGFBR12.66017176
4ERN12.56437923
5RIPK12.37268245
6TIE111.4578892
7EPHB21.87373178
8PTK2B1.81318704
9PTK61.49996959
10TRIB31.47983890
11EPHB11.39226788
12FGFR41.29756236
13GRK11.23490679
14FER1.18548264
15INSRR1.14204705
16MAP2K31.08944845
17PKN21.08844519
18PRKG21.05467514
19MAP3K31.05142843
20ARAF1.04700981
21BMPR1B1.03212440
22PDGFRA1.00349299
23PTK20.96316525
24PAK40.92383444
25WNK40.91161862
26BCKDK0.90336666
27WNK30.85911351
28MAP3K130.81867189
29SIK10.75315118
30MAPK150.74826372
31MAP3K10.74410260
32LRRK20.73339646
33PRKD30.68781395
34MAP3K110.66065370
35CSK0.65392593
36PRKCH0.62656341
37ACVR1B0.61995592
38JAK20.60521344
39CDK80.60058078
40TESK10.59827867
41EPHA20.57015872
42JAK10.56622807
43MET0.56607385
44PDK20.55667075
45FGFR20.55295689
46MYLK0.54401375
47PRKD10.53666211
48MAPK120.53064663
49OXSR10.50938706
50MAP2K20.50319650
51GSK3A0.50105281
52KIT0.49282498
53LATS10.47723839
54MAPKAPK30.47253568
55RET0.47062479
56SCYL20.46188933
57MOS0.46096046
58CDK90.45893643
59FGFR30.43866423
60JAK30.41734778
61EGFR0.40300274
62STK100.39533438
63MAP3K100.38416446
64DAPK20.38163216
65MAP3K20.38057070
66TRPM70.37412034
67MAP4K10.36509294
68CAMK40.36302249
69MAP3K70.36011842
70PRKAA20.35730867
71PDGFRB0.35354772
72IGF1R0.34895015
73TAOK30.33119708
74YES10.32965857
75SRC0.32348891
76HCK0.31833590
77MAP2K10.31636040
78ROCK20.31528225
79PDPK10.31251533
80FES0.29729701
81TTN0.28937066
82TBK10.28752806
83IRAK30.28407902
84EPHA30.28000135
85MAP3K140.26712193
86NTRK10.26396604
87PRKD20.25923209
88TYK20.25698193
89DMPK0.25200508
90KSR20.25038835
91MAPK70.24566788
92CDC42BPA0.23665265
93MAP3K60.22993341
94ZAP700.22894029
95LATS20.22873379
96MATK0.22810444
97EEF2K0.21950817
98ITK0.21748323
99GRK50.20493088
100MAP2K40.20030076
101TYRO30.19642060
102FLT30.19287668
103BMX0.19055355
104CAMK1G0.18441534
105PAK20.17709172
106ERBB40.17408896
107MAP3K90.17144646
108TEC0.16505200
109PRKAA10.16319061
110MARK20.15847717
111INSR0.15738301
112RPS6KA20.15622057
113FGFR10.14723000
114MAPK40.14558223
115ROCK10.13706092
116SGK30.13632985
117MST1R0.13529967
118NLK0.13468710
119MARK30.12666710
120MTOR0.12216765
121DDR20.11674832
122SGK4940.11209445
123SGK2230.11209445
124BRAF0.10831875
125NEK90.10665313
126LCK0.09909035
127FGR0.09160288
128ABL20.08688695
129PRKACG0.07838739
130LYN0.07232521
131PRPF4B0.06715793
132SMG10.06244303
133PIM20.05874642
134FYN0.05722113
135AKT20.05480916
136PIK3CG0.04887203
137MAP2K60.04804981
138ERBB20.03331670

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002202.85934623
2Other glycan degradation_Homo sapiens_hsa005112.68197088
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.64294214
4Nitrogen metabolism_Homo sapiens_hsa009102.60669569
5Complement and coagulation cascades_Homo sapiens_hsa046102.56846753
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.51797762
7Bile secretion_Homo sapiens_hsa049762.48293188
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28233160
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09324473
10Tryptophan metabolism_Homo sapiens_hsa003802.01367519
11ECM-receptor interaction_Homo sapiens_hsa045121.96159801
12Fatty acid degradation_Homo sapiens_hsa000711.92467344
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80631592
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.73634079
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69248144
16PPAR signaling pathway_Homo sapiens_hsa033201.65626530
17Protein digestion and absorption_Homo sapiens_hsa049741.56378558
18Sulfur relay system_Homo sapiens_hsa041221.55687184
19HIF-1 signaling pathway_Homo sapiens_hsa040661.48829891
20Focal adhesion_Homo sapiens_hsa045101.47332369
21Butanoate metabolism_Homo sapiens_hsa006501.45794710
22Dorso-ventral axis formation_Homo sapiens_hsa043201.43869847
23Propanoate metabolism_Homo sapiens_hsa006401.43755247
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39763653
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39213612
26Ras signaling pathway_Homo sapiens_hsa040141.38922058
27Vitamin digestion and absorption_Homo sapiens_hsa049771.38836253
28Pancreatic cancer_Homo sapiens_hsa052121.37158475
29Staphylococcus aureus infection_Homo sapiens_hsa051501.33167981
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33014839
31Fatty acid metabolism_Homo sapiens_hsa012121.26797465
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.25020832
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23016986
34Fat digestion and absorption_Homo sapiens_hsa049751.18118356
35Caffeine metabolism_Homo sapiens_hsa002321.17372829
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16789762
37Renal cell carcinoma_Homo sapiens_hsa052111.12603327
38Malaria_Homo sapiens_hsa051441.12041314
39Peroxisome_Homo sapiens_hsa041461.10582679
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08549109
41ABC transporters_Homo sapiens_hsa020101.06828341
42Rheumatoid arthritis_Homo sapiens_hsa053231.06233218
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05241938
44Amoebiasis_Homo sapiens_hsa051461.04979604
45Adherens junction_Homo sapiens_hsa045201.04026423
46Sulfur metabolism_Homo sapiens_hsa009201.03544215
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.03079068
48African trypanosomiasis_Homo sapiens_hsa051431.02743984
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02254711
50Notch signaling pathway_Homo sapiens_hsa043300.99411100
51Insulin resistance_Homo sapiens_hsa049310.98073772
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97767190
53Pertussis_Homo sapiens_hsa051330.96302654
54Histidine metabolism_Homo sapiens_hsa003400.94511185
55beta-Alanine metabolism_Homo sapiens_hsa004100.94233022
56Endocytosis_Homo sapiens_hsa041440.92683576
57Selenocompound metabolism_Homo sapiens_hsa004500.92609235
58Rap1 signaling pathway_Homo sapiens_hsa040150.91860901
59Small cell lung cancer_Homo sapiens_hsa052220.90507781
60Chronic myeloid leukemia_Homo sapiens_hsa052200.89822382
61Renin secretion_Homo sapiens_hsa049240.89576997
62Pyruvate metabolism_Homo sapiens_hsa006200.86357597
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84924820
64Pathways in cancer_Homo sapiens_hsa052000.83570722
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80757984
66VEGF signaling pathway_Homo sapiens_hsa043700.80716149
67Thyroid cancer_Homo sapiens_hsa052160.79392826
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77012488
69Chemical carcinogenesis_Homo sapiens_hsa052040.76501740
70Platelet activation_Homo sapiens_hsa046110.76065187
71Thyroid hormone synthesis_Homo sapiens_hsa049180.76011201
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75217435
73Phenylalanine metabolism_Homo sapiens_hsa003600.73890764
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72879951
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72580903
76Lysine degradation_Homo sapiens_hsa003100.72133483
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71374056
78Arginine and proline metabolism_Homo sapiens_hsa003300.70744642
79Proteoglycans in cancer_Homo sapiens_hsa052050.70141147
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.69206987
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67954252
82Starch and sucrose metabolism_Homo sapiens_hsa005000.66249825
83Prion diseases_Homo sapiens_hsa050200.65921664
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.64738699
85Ovarian steroidogenesis_Homo sapiens_hsa049130.64558960
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.62964928
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61966134
88Retinol metabolism_Homo sapiens_hsa008300.60035671
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59039635
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58858301
91Leishmaniasis_Homo sapiens_hsa051400.58144460
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57584264
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.57075950
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55450169
95Carbon metabolism_Homo sapiens_hsa012000.54806626
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54115146
97Tyrosine metabolism_Homo sapiens_hsa003500.53265890
98Tight junction_Homo sapiens_hsa045300.52391612
99Pancreatic secretion_Homo sapiens_hsa049720.51145234
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51069231
101Colorectal cancer_Homo sapiens_hsa052100.51045291
102Dilated cardiomyopathy_Homo sapiens_hsa054140.51043488
103Estrogen signaling pathway_Homo sapiens_hsa049150.49028032
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.48509756
105Fatty acid elongation_Homo sapiens_hsa000620.47989918
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47873760
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47692637
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47272759
109Glycerolipid metabolism_Homo sapiens_hsa005610.47145533
110Axon guidance_Homo sapiens_hsa043600.46601160
111Gastric acid secretion_Homo sapiens_hsa049710.46569348
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46507297
113Vibrio cholerae infection_Homo sapiens_hsa051100.46282544
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46252238
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.46192681
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45537415
117Acute myeloid leukemia_Homo sapiens_hsa052210.43967768
118Toxoplasmosis_Homo sapiens_hsa051450.43779413
119Salmonella infection_Homo sapiens_hsa051320.43763734
120TNF signaling pathway_Homo sapiens_hsa046680.42634600
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41663622
122Renin-angiotensin system_Homo sapiens_hsa046140.41610825
123Shigellosis_Homo sapiens_hsa051310.41526265
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41525627
125Gap junction_Homo sapiens_hsa045400.39527400
126Bladder cancer_Homo sapiens_hsa052190.39400711
127Phagosome_Homo sapiens_hsa041450.38670015
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37809954
129Folate biosynthesis_Homo sapiens_hsa007900.37589720
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.37477722
131GnRH signaling pathway_Homo sapiens_hsa049120.37380693
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.37131514
133Hepatitis C_Homo sapiens_hsa051600.36603624
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.36379884
135TGF-beta signaling pathway_Homo sapiens_hsa043500.35746681
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34042472
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33593428
138Choline metabolism in cancer_Homo sapiens_hsa052310.32565969
139Lysosome_Homo sapiens_hsa041420.32444472
140Tuberculosis_Homo sapiens_hsa051520.32039982
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.32037192
142Glutathione metabolism_Homo sapiens_hsa004800.32031353
143Hematopoietic cell lineage_Homo sapiens_hsa046400.31629974
144Osteoclast differentiation_Homo sapiens_hsa043800.30622842
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28020217

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