PLK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.55633972
2detection of light stimulus involved in sensory perception (GO:0050962)9.37482331
3detection of light stimulus involved in visual perception (GO:0050908)9.37482331
4cellular potassium ion homeostasis (GO:0030007)7.35263328
5retinal rod cell development (GO:0046548)6.99503068
6negative regulation of cytosolic calcium ion concentration (GO:0051481)6.84343916
7positive regulation of synapse maturation (GO:0090129)6.83521032
8sodium ion export (GO:0071436)6.62693166
9G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.52671611
10synaptic vesicle exocytosis (GO:0016079)6.14008465
11potassium ion homeostasis (GO:0055075)5.89297869
12protein localization to synapse (GO:0035418)5.81051300
13gamma-aminobutyric acid signaling pathway (GO:0007214)5.77862905
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.48602850
15regulation of synapse maturation (GO:0090128)5.33460368
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.25998730
17neuronal ion channel clustering (GO:0045161)5.23407461
18regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18069362
19retinal cone cell development (GO:0046549)5.02008675
20synaptic vesicle endocytosis (GO:0048488)4.97367675
21otic vesicle formation (GO:0030916)4.94457290
22postsynaptic membrane organization (GO:0001941)4.94110556
23synaptic vesicle maturation (GO:0016188)4.91886365
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91314762
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.89694973
26regulation of synaptic vesicle exocytosis (GO:2000300)4.87712888
27auditory behavior (GO:0031223)4.76917466
28cell communication by electrical coupling (GO:0010644)4.67146716
29relaxation of smooth muscle (GO:0044557)4.64468998
30lung epithelium development (GO:0060428)4.45036224
31cellular sodium ion homeostasis (GO:0006883)4.38521090
32rhodopsin mediated signaling pathway (GO:0016056)4.35772849
33photoreceptor cell development (GO:0042461)4.32717079
34glutamate receptor signaling pathway (GO:0007215)4.31563545
35eye photoreceptor cell development (GO:0042462)4.28526489
36neurotransmitter-gated ion channel clustering (GO:0072578)4.24418241
37urinary tract smooth muscle contraction (GO:0014848)4.24200111
38positive regulation of dendritic spine morphogenesis (GO:0061003)4.22576663
39photoreceptor cell maintenance (GO:0045494)4.18612218
40myelination in peripheral nervous system (GO:0022011)4.15453170
41peripheral nervous system axon ensheathment (GO:0032292)4.15453170
42glomerular basement membrane development (GO:0032836)4.13295304
43regulation of synaptic vesicle transport (GO:1902803)4.13122226
44innervation (GO:0060384)4.12443804
45mating behavior (GO:0007617)4.03175721
46glutamate secretion (GO:0014047)3.99667333
47vocalization behavior (GO:0071625)3.96359529
48membrane hyperpolarization (GO:0060081)3.95733763
49lateral sprouting from an epithelium (GO:0060601)3.90862898
50neuronal action potential propagation (GO:0019227)3.87430334
51regulation of neuronal synaptic plasticity (GO:0048168)3.84902133
52regulation of voltage-gated calcium channel activity (GO:1901385)3.84117062
53regulation of neurotransmitter levels (GO:0001505)3.82662974
54regulation of rhodopsin mediated signaling pathway (GO:0022400)3.81529436
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80393223
56calcium ion import (GO:0070509)3.75673797
57membrane depolarization during action potential (GO:0086010)3.73553665
58dendritic spine morphogenesis (GO:0060997)3.73167036
59striatum development (GO:0021756)3.70358735
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68835279
61synaptic vesicle docking involved in exocytosis (GO:0016081)3.67773057
62neurotransmitter secretion (GO:0007269)3.67261964
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67062325
64organ growth (GO:0035265)3.64518128
65long-term synaptic potentiation (GO:0060291)3.59915280
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.59878669
67regulation of synapse structural plasticity (GO:0051823)3.59785633
68prepulse inhibition (GO:0060134)3.59118642
69neuron-neuron synaptic transmission (GO:0007270)3.58858585
70mechanosensory behavior (GO:0007638)3.58787752
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58717223
72response to auditory stimulus (GO:0010996)3.57273870
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56050986
74exploration behavior (GO:0035640)3.55616782
75mesenchymal-epithelial cell signaling (GO:0060638)3.54956168
76gamma-aminobutyric acid transport (GO:0015812)3.50581474
77synaptic vesicle transport (GO:0048489)3.50007232
78establishment of synaptic vesicle localization (GO:0097480)3.50007232
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.49079809
80potassium ion export (GO:0071435)3.48652685
81synaptic transmission, glutamatergic (GO:0035249)3.48534931
82regulation of neurotransmitter secretion (GO:0046928)3.48524868
83positive regulation of dendritic spine development (GO:0060999)3.44815971
84protein-chromophore linkage (GO:0018298)3.44582630
85limb bud formation (GO:0060174)3.43243765
86cerebellar Purkinje cell differentiation (GO:0021702)3.40790479
87synapse assembly (GO:0007416)3.38224655
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37934716
89long-term memory (GO:0007616)3.36265690
90neurotransmitter transport (GO:0006836)3.35547599
91cerebellar granule cell differentiation (GO:0021707)3.34905517
92amino acid import (GO:0043090)3.32347676
93ionotropic glutamate receptor signaling pathway (GO:0035235)3.32308214
94locomotory exploration behavior (GO:0035641)3.30119825
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27427068
96regulation of neurotransmitter transport (GO:0051588)3.27200644
97neuromuscular process controlling balance (GO:0050885)3.25783889
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25493230
99sensory perception of light stimulus (GO:0050953)3.23546238
100response to histamine (GO:0034776)3.22906446
101layer formation in cerebral cortex (GO:0021819)3.22507859
102visual perception (GO:0007601)3.21862027
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18813283
104positive regulation of membrane potential (GO:0045838)3.18629943
105potassium ion import (GO:0010107)3.17863444
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16857161
107long term synaptic depression (GO:0060292)3.16420136
108peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15941786
109axon cargo transport (GO:0008088)3.14575598
110behavioral defense response (GO:0002209)3.13502454
111behavioral fear response (GO:0001662)3.13502454
112regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.12594783
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.12594783
114presynaptic membrane assembly (GO:0097105)3.11333973
115regulation of glutamate receptor signaling pathway (GO:1900449)3.07555859
116L-amino acid import (GO:0043092)3.07289762
117regulation of dendritic spine morphogenesis (GO:0061001)3.06716794
118positive regulation of potassium ion transmembrane transport (GO:1901381)3.03692816
119regulation of vesicle fusion (GO:0031338)3.02789777
120presynaptic membrane organization (GO:0097090)3.02561329
121cellular potassium ion transport (GO:0071804)3.02362018
122potassium ion transmembrane transport (GO:0071805)3.02362018
123positive regulation of gastrulation (GO:2000543)3.01998869
124detection of light stimulus (GO:0009583)3.01816824
125positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01401723
126membrane depolarization (GO:0051899)3.01069140
127detection of visible light (GO:0009584)3.00553606
128behavioral response to ethanol (GO:0048149)2.98608221
129cell differentiation in hindbrain (GO:0021533)2.96774028
130membrane repolarization (GO:0086009)2.96468065
131axon ensheathment in central nervous system (GO:0032291)2.96389288
132central nervous system myelination (GO:0022010)2.96389288
133neuromuscular process controlling posture (GO:0050884)2.95522598
134cerebellar Purkinje cell layer development (GO:0021680)2.94292359
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.94112593
136regulation of postsynaptic membrane potential (GO:0060078)2.93938601
137dendritic spine organization (GO:0097061)2.92347456
138synaptic transmission (GO:0007268)2.91644197
139neuron cell-cell adhesion (GO:0007158)2.91446205
140regulation of synaptic plasticity (GO:0048167)2.90255984
141neurotransmitter uptake (GO:0001504)2.89206754
142branch elongation of an epithelium (GO:0060602)2.86477082
143positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81214215
144negative regulation of actin filament bundle assembly (GO:0032232)2.79545215
145positive regulation of neurotransmitter transport (GO:0051590)2.76498657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.38231427
2GBX2_23144817_ChIP-Seq_PC3_Human3.67032520
3REST_21632747_ChIP-Seq_MESCs_Mouse3.17686426
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.08287967
5DROSHA_22980978_ChIP-Seq_HELA_Human3.05583071
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79233851
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68481271
8* EZH2_27294783_Chip-Seq_ESCs_Mouse2.67180865
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.66232764
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59680166
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55413308
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51922115
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48027817
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45788357
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45366909
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.44310085
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43806504
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36745201
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36745201
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36110224
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33177468
22EZH2_22144423_ChIP-Seq_EOC_Human2.18438317
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.18190797
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.16540008
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15182118
26* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13277526
27P53_22127205_ChIP-Seq_FIBROBLAST_Human2.09069459
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07730385
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99327672
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93201198
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89083519
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85786970
33AR_21572438_ChIP-Seq_LNCaP_Human1.77152494
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70497118
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67805375
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62530620
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60190903
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.59511333
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58961450
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53985373
41SMAD4_21799915_ChIP-Seq_A2780_Human1.53143388
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49587308
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.48905013
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48250967
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47841707
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46424065
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.46267659
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44496410
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39385131
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37084833
51AR_19668381_ChIP-Seq_PC3_Human1.36285221
52IGF1R_20145208_ChIP-Seq_DFB_Human1.35440888
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35243284
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32878732
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28980513
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28127923
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28003762
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27534176
59* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25226281
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24957604
61TAF15_26573619_Chip-Seq_HEK293_Human1.24833794
62AR_25329375_ChIP-Seq_VCAP_Human1.24798064
63CTCF_27219007_Chip-Seq_Bcells_Human1.21415732
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18337132
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18100959
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.17832383
67RNF2_27304074_Chip-Seq_NSC_Mouse1.17040168
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.15504526
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15499237
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.14957299
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.14262714
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.12848045
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.11154365
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10973917
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.08573011
76STAT3_23295773_ChIP-Seq_U87_Human1.08510144
77STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07904669
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07451802
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07198857
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05917669
81LXR_22292898_ChIP-Seq_THP-1_Human1.05345000
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04287131
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02888300
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02354846
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.02242417
86ZNF274_21170338_ChIP-Seq_K562_Hela1.02030954
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00813759
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99816211
89TCF4_23295773_ChIP-Seq_U87_Human0.99649103
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99629527
91FUS_26573619_Chip-Seq_HEK293_Human0.99157327
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98861328
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98351343
94P300_19829295_ChIP-Seq_ESCs_Human0.98236505
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97869133
96EGR1_19032775_ChIP-ChIP_M12_Human0.97374676
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.97158468
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96541128
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95335171
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94528055
101KDM2B_26808549_Chip-Seq_K562_Human0.94107021
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93663542
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.90631179
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.90276594
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90094913
106SMC4_20622854_ChIP-Seq_HELA_Human0.89533711
107* FLI1_21867929_ChIP-Seq_TH2_Mouse0.89327843
108OCT4_19829295_ChIP-Seq_ESCs_Human0.88285666
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87583518
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.87118765
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86871770
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85882040
113KLF4_19829295_ChIP-Seq_ESCs_Human0.85630766
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83076529
115CBP_20019798_ChIP-Seq_JUKART_Human0.83076529
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82863015
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82510313
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82279856
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.81474574
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.81078130
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80556491
122CREB1_26743006_Chip-Seq_LNCaP_Human0.80269866
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80195643
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80006158
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78011007
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77255793
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76677500
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75962144
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75934823
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.74635974
131CTCF_20526341_ChIP-Seq_ESCs_Human0.74007562
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.73456976
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.72923634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.13214437
2MP0006072_abnormal_retinal_apoptosis4.12879625
3MP0003878_abnormal_ear_physiology4.09590495
4MP0005377_hearing/vestibular/ear_phenot4.09590495
5MP0002090_abnormal_vision3.82420617
6MP0001984_abnormal_olfaction3.78222353
7MP0004859_abnormal_synaptic_plasticity3.62187431
8MP0005253_abnormal_eye_physiology3.20357372
9MP0003880_abnormal_central_pattern3.10994680
10MP0005257_abnormal_intraocular_pressure2.96148506
11MP0002102_abnormal_ear_morphology2.89570238
12MP0001502_abnormal_circadian_rhythm2.84744864
13MP0003635_abnormal_synaptic_transmissio2.78364073
14MP0009046_muscle_twitch2.73781172
15MP0004233_abnormal_muscle_weight2.60955592
16MP0006292_abnormal_olfactory_placode2.48693101
17MP0003011_delayed_dark_adaptation2.44177596
18MP0005195_abnormal_posterior_eye2.37202250
19MP0002064_seizures2.34776208
20MP0002272_abnormal_nervous_system2.31774721
21MP0001486_abnormal_startle_reflex2.29961058
22MP0002063_abnormal_learning/memory/cond2.25617743
23MP0005423_abnormal_somatic_nervous2.24371889
24MP0009745_abnormal_behavioral_response2.20040949
25MP0002638_abnormal_pupillary_reflex2.10355849
26MP0003950_abnormal_plasma_membrane2.09751495
27MP0000566_synostosis2.07910603
28MP0005670_abnormal_white_adipose2.06020128
29MP0001346_abnormal_lacrimal_gland2.05171620
30MP0001968_abnormal_touch/_nociception2.00674889
31MP0002067_abnormal_sensory_capabilities1.91874483
32MP0005394_taste/olfaction_phenotype1.91470675
33MP0005499_abnormal_olfactory_system1.91470675
34MP0002572_abnormal_emotion/affect_behav1.85550703
35MP0002734_abnormal_mechanical_nocicepti1.83574702
36MP0002229_neurodegeneration1.83031132
37MP0004215_abnormal_myocardial_fiber1.80050766
38MP0002184_abnormal_innervation1.79381033
39MP0002736_abnormal_nociception_after1.72774252
40MP0004782_abnormal_surfactant_physiolog1.68790692
41MP0001501_abnormal_sleep_pattern1.66672763
42MP0008569_lethality_at_weaning1.61666092
43MP0008789_abnormal_olfactory_epithelium1.59268898
44MP0002752_abnormal_somatic_nervous1.55945745
45MP0004145_abnormal_muscle_electrophysio1.55485156
46MP0001905_abnormal_dopamine_level1.51964811
47MP0000579_abnormal_nail_morphology1.51665906
48MP0002882_abnormal_neuron_morphology1.51655936
49MP0010386_abnormal_urinary_bladder1.44943515
50MP0001324_abnormal_eye_pigmentation1.44149687
51MP0003879_abnormal_hair_cell1.43714063
52MP0002822_catalepsy1.41886532
53MP0002735_abnormal_chemical_nociception1.41645719
54MP0005391_vision/eye_phenotype1.40781035
55MP0004270_analgesia1.33913511
56MP0005248_abnormal_Harderian_gland1.31223165
57MP0000026_abnormal_inner_ear1.29720433
58MP0003938_abnormal_ear_development1.29388292
59MP0002234_abnormal_pharynx_morphology1.28187890
60MP0010030_abnormal_orbit_morphology1.26758736
61MP0003122_maternal_imprinting1.23955712
62MP0004142_abnormal_muscle_tone1.23427403
63MP0001440_abnormal_grooming_behavior1.22742204
64MP0005623_abnormal_meninges_morphology1.21764277
65MP0001188_hyperpigmentation1.20859419
66MP0002653_abnormal_ependyma_morphology1.20595010
67MP0000955_abnormal_spinal_cord1.18679444
68MP0004742_abnormal_vestibular_system1.17780439
69MP0002557_abnormal_social/conspecific_i1.17159482
70MP0002909_abnormal_adrenal_gland1.13824245
71MP0005386_behavior/neurological_phenoty1.10987537
72MP0004924_abnormal_behavior1.10987537
73MP0003787_abnormal_imprinting1.08314586
74MP0004885_abnormal_endolymph1.07539382
75MP0004036_abnormal_muscle_relaxation1.07294408
76MP0000631_abnormal_neuroendocrine_gland1.07213625
77MP0001299_abnormal_eye_distance/1.06228476
78MP0002332_abnormal_exercise_endurance1.06009054
79MP0004811_abnormal_neuron_physiology1.05882838
80MP0005595_abnormal_vascular_smooth1.05489920
81MP0009780_abnormal_chondrocyte_physiolo1.04119179
82MP0001970_abnormal_pain_threshold1.03120990
83MP0002066_abnormal_motor_capabilities/c1.01146943
84MP0003137_abnormal_impulse_conducting1.00377715
85MP0003329_amyloid_beta_deposits0.99798517
86MP0001529_abnormal_vocalization0.99662437
87MP0004084_abnormal_cardiac_muscle0.99274987
88MP0001177_atelectasis0.98634770
89MP0003634_abnormal_glial_cell0.94154278
90MP0008872_abnormal_physiological_respon0.92812069
91MP0003690_abnormal_glial_cell0.90949150
92MP0010368_abnormal_lymphatic_system0.89278680
93MP0008775_abnormal_heart_ventricle0.88966516
94MP0009250_abnormal_appendicular_skeleto0.87424028
95MP0003123_paternal_imprinting0.85757708
96MP0000534_abnormal_ureter_morphology0.84605875
97MP0000920_abnormal_myelination0.83078131
98MP0002152_abnormal_brain_morphology0.81913193
99MP0002249_abnormal_larynx_morphology0.80071027
100MP0005503_abnormal_tendon_morphology0.79832601
101MP0003633_abnormal_nervous_system0.79069442
102MP0004147_increased_porphyrin_level0.78790109
103MP0004085_abnormal_heartbeat0.78698894
104MP0002069_abnormal_eating/drinking_beha0.78665238
105MP0000751_myopathy0.75514546
106MP0004133_heterotaxia0.74850954
107MP0001348_abnormal_lacrimal_gland0.72364555
108MP0001963_abnormal_hearing_physiology0.72301857
109MP0004043_abnormal_pH_regulation0.71301478
110MP0000778_abnormal_nervous_system0.69554084
111MP0008877_abnormal_DNA_methylation0.67844463
112MP0000639_abnormal_adrenal_gland0.67726404
113MP0000049_abnormal_middle_ear0.67341248
114MP0001485_abnormal_pinna_reflex0.66904508
115MP0008961_abnormal_basal_metabolism0.65775941
116MP0006035_abnormal_mitochondrial_morpho0.65670424
117MP0005167_abnormal_blood-brain_barrier0.64362884
118MP0003631_nervous_system_phenotype0.64358585
119MP0002089_abnormal_postnatal_growth/wei0.64290112
120MP0000013_abnormal_adipose_tissue0.62544824
121MP0003119_abnormal_digestive_system0.61893822
122MP0001756_abnormal_urination0.61581153
123MP0003890_abnormal_embryonic-extraembry0.61504096
124MP0003861_abnormal_nervous_system0.61243491
125MP0006276_abnormal_autonomic_nervous0.60899060
126MP0005535_abnormal_body_temperature0.60832094
127MP0002295_abnormal_pulmonary_circulatio0.59178976
128MP0010769_abnormal_survival0.57558895
129MP0000462_abnormal_digestive_system0.57491364
130MP0003698_abnormal_male_reproductive0.54758292
131MP0005646_abnormal_pituitary_gland0.53537728
132MP0005620_abnormal_muscle_contractility0.51181333
133MP0002269_muscular_atrophy0.48434462
134MP0002733_abnormal_thermal_nociception0.47696275
135MP0003632_abnormal_nervous_system0.47096543

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.69601719
2Abnormality of macular pigmentation (HP:0008002)7.37997875
3Severe visual impairment (HP:0001141)6.72996127
4Abnormal rod and cone electroretinograms (HP:0008323)6.38263378
5Scotoma (HP:0000575)6.12679748
6Bony spicule pigmentary retinopathy (HP:0007737)5.45630127
7Aplasia involving bones of the extremities (HP:0009825)5.25702338
8Aplasia involving bones of the upper limbs (HP:0009823)5.25702338
9Aplasia of the phalanges of the hand (HP:0009802)5.25702338
10Decreased central vision (HP:0007663)5.10428029
11Epileptic encephalopathy (HP:0200134)4.78211781
12Septo-optic dysplasia (HP:0100842)4.48550963
13Febrile seizures (HP:0002373)4.40323820
14Partial duplication of thumb phalanx (HP:0009944)4.32730673
15Diplopia (HP:0000651)4.27809780
16Abnormality of binocular vision (HP:0011514)4.27809780
17Partial duplication of the phalanx of hand (HP:0009999)3.86078282
18Progressive cerebellar ataxia (HP:0002073)3.85626154
19Keratoconus (HP:0000563)3.83491024
20Increased corneal curvature (HP:0100692)3.83491024
21Hypoplasia of the fovea (HP:0007750)3.76534328
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.76534328
23Concave nail (HP:0001598)3.72789413
24Alacrima (HP:0000522)3.69932022
25Attenuation of retinal blood vessels (HP:0007843)3.63719744
26Absence seizures (HP:0002121)3.56068524
27Neurofibrillary tangles (HP:0002185)3.56043650
28Recurrent corneal erosions (HP:0000495)3.53447962
29Abnormal gallbladder physiology (HP:0012438)3.49179409
30Cholecystitis (HP:0001082)3.49179409
31Mixed hearing impairment (HP:0000410)3.41710479
32Cerebral inclusion bodies (HP:0100314)3.34468298
33Visual hallucinations (HP:0002367)3.33341741
34Myokymia (HP:0002411)3.27475552
35Abnormality of the fovea (HP:0000493)3.22997882
36Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22106077
37Limb dystonia (HP:0002451)3.14299789
38Albinism (HP:0001022)3.12938347
39Glomerulonephritis (HP:0000099)3.04701810
40Pendular nystagmus (HP:0012043)3.04237403
41Dialeptic seizures (HP:0011146)3.02528315
42Chorioretinal atrophy (HP:0000533)3.00244061
43Dysdiadochokinesis (HP:0002075)2.96951420
44Focal motor seizures (HP:0011153)2.92449044
45Abnormality of the lower motor neuron (HP:0002366)2.85574135
46Spastic gait (HP:0002064)2.84992842
47Action tremor (HP:0002345)2.84213354
48Decreased lacrimation (HP:0000633)2.80823867
49Photophobia (HP:0000613)2.76961959
50Abnormal eating behavior (HP:0100738)2.75171539
51Abolished electroretinogram (ERG) (HP:0000550)2.68414851
52Hemiparesis (HP:0001269)2.68376704
53Mutism (HP:0002300)2.66506268
54Abnormality of the musculature of the hand (HP:0001421)2.66064812
55Focal seizures (HP:0007359)2.65682326
56Aplasia/Hypoplasia of the macula (HP:0008059)2.60162108
57Annular pancreas (HP:0001734)2.59251212
58Type II diabetes mellitus (HP:0005978)2.59117289
59Pigmentary retinal degeneration (HP:0001146)2.53872732
60Dyschromatopsia (HP:0007641)2.53782512
61Turricephaly (HP:0000262)2.52601389
62Cone-rod dystrophy (HP:0000548)2.51511079
63Aplasia/Hypoplasia affecting the retina (HP:0008061)2.46862473
64Congenital sensorineural hearing impairment (HP:0008527)2.46178859
65Gait imbalance (HP:0002141)2.42897294
66Retinitis pigmentosa (HP:0000510)2.42204843
67Heterochromia iridis (HP:0001100)2.41199327
68Generalized tonic-clonic seizures (HP:0002069)2.40666645
69Papilledema (HP:0001085)2.38933352
70Prolonged QT interval (HP:0001657)2.38129107
71Ventricular fibrillation (HP:0001663)2.37295697
72Corneal erosion (HP:0200020)2.36355769
73Duplication of thumb phalanx (HP:0009942)2.35927872
74Cerebral hypomyelination (HP:0006808)2.33750065
75Absent septum pellucidum (HP:0001331)2.33692772
76Depression (HP:0000716)2.33009406
77Abnormality of incisor morphology (HP:0011063)2.32721393
78Congenital primary aphakia (HP:0007707)2.30749786
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.30445855
80Optic nerve hypoplasia (HP:0000609)2.30346612
81Bradykinesia (HP:0002067)2.28366359
82Unsteady gait (HP:0002317)2.27561230
83Choroideremia (HP:0001139)2.26393196
84Stereotypic behavior (HP:0000733)2.20607402
85Conical tooth (HP:0000698)2.19778038
86Gaze-evoked nystagmus (HP:0000640)2.17753966
87Obstructive sleep apnea (HP:0002870)2.17607103
88Hemiplegia (HP:0002301)2.15566627
89Poor eye contact (HP:0000817)2.14541655
90Nephritis (HP:0000123)2.11029917
91EEG with generalized epileptiform discharges (HP:0011198)2.10143359
92Sleep apnea (HP:0010535)2.09141938
93Neoplasm of the heart (HP:0100544)2.08658850
94Nephrogenic diabetes insipidus (HP:0009806)2.08604542
95Lower limb muscle weakness (HP:0007340)2.08066165
96Atonic seizures (HP:0010819)2.07782403
97Intention tremor (HP:0002080)2.06884174
98Overfolded helix (HP:0000396)2.05029071
99Epileptiform EEG discharges (HP:0011182)2.04379091
100Urinary bladder sphincter dysfunction (HP:0002839)2.04006023
101Bronchomalacia (HP:0002780)2.03578306
102Medial flaring of the eyebrow (HP:0010747)2.03391652
103Neuronal loss in central nervous system (HP:0002529)2.02794707
104Aqueductal stenosis (HP:0002410)2.01221530
105Congenital stationary night blindness (HP:0007642)14.0174415
106Dysmetric saccades (HP:0000641)1.99584213
107Split foot (HP:0001839)1.99126430
108Clonus (HP:0002169)1.96983039
109Akinesia (HP:0002304)1.96889562
110Abnormally folded helix (HP:0008544)1.96146489
111Generalized hypopigmentation (HP:0007513)1.95782063
112Abnormality of the septum pellucidum (HP:0007375)1.95597312
113Severe Myopia (HP:0011003)1.94666174
114Abdominal situs inversus (HP:0003363)1.94384482
115Abnormality of abdominal situs (HP:0011620)1.94384482
116Humeroradial synostosis (HP:0003041)1.93287561
117Synostosis involving the elbow (HP:0003938)1.93287561
118Constricted visual fields (HP:0001133)1.93074716
119Torticollis (HP:0000473)1.92108564
120Posterior subcapsular cataract (HP:0007787)1.91830953
121Hypoplasia of the ulna (HP:0003022)1.91824808
122Choreoathetosis (HP:0001266)1.91430505
123Rigidity (HP:0002063)1.91076528
124Abnormality of the salivary glands (HP:0010286)1.90782712
125Nasolacrimal duct obstruction (HP:0000579)1.90550200
126Macular degeneration (HP:0000608)1.90047612
127Abnormal EKG (HP:0003115)1.89222611
128Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.88292205
129Ankle clonus (HP:0011448)1.87476645
130Poor coordination (HP:0002370)1.87193665
131Focal dystonia (HP:0004373)1.86028946
132Confusion (HP:0001289)1.85367410
133Abnormal pupillary function (HP:0007686)1.83791563
134Increased circulating renin level (HP:0000848)1.83735792
135Nonprogressive disorder (HP:0003680)1.83549284
136Supranuclear gaze palsy (HP:0000605)1.82660364
137Exercise-induced myalgia (HP:0003738)1.81924253
138Cupped ear (HP:0000378)1.81883135
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81579531
140Postural instability (HP:0002172)1.81549635
141Abnormal social behavior (HP:0012433)1.81471561
142Impaired social interactions (HP:0000735)1.81471561
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81079562
144Poor suck (HP:0002033)1.81055682
145Truncal ataxia (HP:0002078)1.80966011
146Congenital malformation of the right heart (HP:0011723)1.79512338
147Double outlet right ventricle (HP:0001719)1.79512338
148Ependymoma (HP:0002888)1.78952804
149Polar cataract (HP:0010696)1.78153742
150Aplasia/Hypoplasia of the lens (HP:0008063)1.77830165
151Polyphagia (HP:0002591)1.76727659
152Absent radius (HP:0003974)1.76162269
153Genetic anticipation (HP:0003743)1.74887526
154Craniofacial dystonia (HP:0012179)1.74708692
155Dysmetria (HP:0001310)1.74651763
156Aplasia involving forearm bones (HP:0009822)1.73658805
157Anxiety (HP:0000739)1.73479111
158Hand muscle atrophy (HP:0009130)1.69231538
159Status epilepticus (HP:0002133)1.68312068
160Abnormality of ocular smooth pursuit (HP:0000617)1.67000544
161Syncope (HP:0001279)1.63662351
162Scanning speech (HP:0002168)1.63326693
163Chorioretinal coloboma (HP:0000567)1.63069921
164Shoulder girdle muscle weakness (HP:0003547)1.61118205
165Astigmatism (HP:0000483)1.59123309
166Incomplete penetrance (HP:0003829)1.58641962
167Impaired smooth pursuit (HP:0007772)1.58439636
168Vaginal atresia (HP:0000148)1.58312219
169Abnormality of alanine metabolism (HP:0010916)1.56891652
170Hyperalaninemia (HP:0003348)1.56891652
171Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56891652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.73515002
2PAK63.58956394
3PRPF4B3.25881019
4MAP3K93.07584173
5PBK2.96172873
6UHMK12.88016429
7EPHA42.76454532
8STK382.72805146
9RIPK12.62929968
10PINK12.61501059
11MAP3K132.56287000
12NTRK32.41797530
13TAOK22.36328104
14MINK12.22236991
15MAP3K42.18506357
16DYRK1A2.13776705
17MARK12.12948687
18PHKG12.09451012
19PHKG22.09451012
20NTRK12.04951427
21TYRO32.04665981
22IRAK22.02576834
23NME11.95926043
24EPHA31.69198376
25STK38L1.65800272
26LATS21.54325151
27KSR21.49008093
28FGFR21.47857776
29ARAF1.47164954
30GRK11.42136703
31FES1.39044439
32MAPK121.31602868
33INSRR1.31494665
34CAMKK21.30044460
35MAP3K71.28691739
36CAMKK11.28359845
37CAMK11.28191801
38DAPK21.27306410
39MAPKAPK51.23958938
40MAP2K71.17109028
41CAMK2D1.13641082
42CDK141.12659561
43CDK31.08766835
44PRKCG1.07204777
45PLK21.06881496
46CDK151.06636200
47NTRK21.04424388
48CDK181.02312737
49TNIK1.02293496
50CDK51.00461676
51CDK11A0.95949827
52KSR10.95338089
53SGK2230.94865765
54SGK4940.94865765
55FER0.94517153
56SGK30.94195257
57TNK20.93857833
58DYRK20.92192761
59PRKAA10.90156142
60TESK10.88822188
61CDK190.86974756
62GRK50.86023486
63PRKG20.85675805
64PRKD30.83324904
65AKT30.82693986
66CAMK1D0.81407992
67PRKD20.80674797
68CSNK1G20.79100403
69MARK20.77808396
70MAP2K40.77139852
71STK110.76972516
72CAMK2A0.76237900
73DAPK30.75784027
74NEK60.74290058
75PAK30.72644433
76MAPK100.66019452
77CSNK1A1L0.65919060
78BRAF0.64684618
79ALK0.64658089
80CAMK1G0.64592030
81LMTK20.63395745
82CSNK1G30.62262767
83PLK30.61316659
84PRKCA0.59531681
85RPS6KA30.58181449
86CLK10.57680797
87CDC42BPA0.54910275
88DYRK1B0.54296241
89SIK20.53220450
90PRKCZ0.52874814
91CAMK40.52569001
92PRKCE0.51814239
93PRKG10.51158882
94GSK3B0.50856502
95RIPK40.48842594
96RET0.48750249
97WNK10.48618736
98PDK10.48223036
99AKT20.47937795
100MOS0.47237569
101PRKCB0.47174591
102ERBB30.47057754
103PKN10.46901600
104MAPK130.45899685
105MAPK90.45376318
106PRKACA0.45196333
107CSNK1E0.44372591
108CDK80.44089897
109PDPK10.42522341
110PRKACB0.41578671
111SGK10.40946330
112FGFR10.40429252
113PNCK0.40183264
114ERBB20.40156940
115SGK20.39678677
116CSNK1G10.39248244
117MAPK40.39090510
118BRSK10.38420014
119PTK2B0.38293076
120CAMK2B0.37992646
121RAF10.37841560
122MAPK80.37785216
123MAP2K60.37570777
124CAMK2G0.36239599
125DAPK10.35336173
126MAP4K20.34908330
127ROCK20.34852527
128MAP3K10.34691722
129BCKDK0.32983647
130MAPK140.32923674
131MAPK70.32567206
132PRKCH0.32434810
133CASK0.32244199
134RPS6KA20.30857688

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.14903967
2Synaptic vesicle cycle_Homo sapiens_hsa047214.22677972
3GABAergic synapse_Homo sapiens_hsa047274.01918969
4Phototransduction_Homo sapiens_hsa047443.96497688
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.50940331
6Morphine addiction_Homo sapiens_hsa050323.35453074
7Circadian entrainment_Homo sapiens_hsa047132.80756728
8Circadian rhythm_Homo sapiens_hsa047102.37436560
9Olfactory transduction_Homo sapiens_hsa047402.34168355
10Glutamatergic synapse_Homo sapiens_hsa047242.30426829
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.14944694
12Insulin secretion_Homo sapiens_hsa049112.09698853
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95488991
14Salivary secretion_Homo sapiens_hsa049701.90428646
15Cholinergic synapse_Homo sapiens_hsa047251.88643114
16Nitrogen metabolism_Homo sapiens_hsa009101.85169660
17Renin secretion_Homo sapiens_hsa049241.77120335
18Fructose and mannose metabolism_Homo sapiens_hsa000511.74181823
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73713747
20Taste transduction_Homo sapiens_hsa047421.71597310
21Oxytocin signaling pathway_Homo sapiens_hsa049211.66512061
22Collecting duct acid secretion_Homo sapiens_hsa049661.66232290
23Dopaminergic synapse_Homo sapiens_hsa047281.63113544
24Serotonergic synapse_Homo sapiens_hsa047261.62075017
25Cardiac muscle contraction_Homo sapiens_hsa042601.59595556
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53643291
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41112411
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38873849
29Calcium signaling pathway_Homo sapiens_hsa040201.38327390
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36789057
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28437070
32Long-term potentiation_Homo sapiens_hsa047201.22813214
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21929770
34Amphetamine addiction_Homo sapiens_hsa050311.21287490
35Biosynthesis of amino acids_Homo sapiens_hsa012301.15789375
36Dilated cardiomyopathy_Homo sapiens_hsa054141.14262109
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13364587
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10478532
39Long-term depression_Homo sapiens_hsa047301.08029318
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97937583
41Melanogenesis_Homo sapiens_hsa049160.97201486
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96724266
43Vitamin B6 metabolism_Homo sapiens_hsa007500.96286225
44Type II diabetes mellitus_Homo sapiens_hsa049300.96229795
45cAMP signaling pathway_Homo sapiens_hsa040240.92469816
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.89672530
47Gastric acid secretion_Homo sapiens_hsa049710.89456768
48Alzheimers disease_Homo sapiens_hsa050100.89437352
49Mineral absorption_Homo sapiens_hsa049780.83980289
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83724418
51Gap junction_Homo sapiens_hsa045400.83310105
52Oxidative phosphorylation_Homo sapiens_hsa001900.80962280
53GnRH signaling pathway_Homo sapiens_hsa049120.80659157
54Cocaine addiction_Homo sapiens_hsa050300.80145503
55Parkinsons disease_Homo sapiens_hsa050120.79380009
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.78926861
57Pentose phosphate pathway_Homo sapiens_hsa000300.78025624
58Protein digestion and absorption_Homo sapiens_hsa049740.77394613
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75770063
60Vibrio cholerae infection_Homo sapiens_hsa051100.74684240
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73994290
62Glioma_Homo sapiens_hsa052140.72908850
63Melanoma_Homo sapiens_hsa052180.70599443
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70540065
65Arginine and proline metabolism_Homo sapiens_hsa003300.69400188
66Pancreatic secretion_Homo sapiens_hsa049720.68311803
67Sulfur relay system_Homo sapiens_hsa041220.67394167
68Rap1 signaling pathway_Homo sapiens_hsa040150.67258736
69Galactose metabolism_Homo sapiens_hsa000520.66359814
70Inositol phosphate metabolism_Homo sapiens_hsa005620.65201517
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64888665
72Bile secretion_Homo sapiens_hsa049760.60804118
73Prion diseases_Homo sapiens_hsa050200.59260353
74mTOR signaling pathway_Homo sapiens_hsa041500.58453448
75ECM-receptor interaction_Homo sapiens_hsa045120.57929525
76Wnt signaling pathway_Homo sapiens_hsa043100.56231628
77Alcoholism_Homo sapiens_hsa050340.52053200
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49885447
79Hippo signaling pathway_Homo sapiens_hsa043900.49058078
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45610557
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.45193745
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.44335107
83Carbon metabolism_Homo sapiens_hsa012000.43357474
84Oocyte meiosis_Homo sapiens_hsa041140.43353916
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.43304575
86Hedgehog signaling pathway_Homo sapiens_hsa043400.43268302
87Glucagon signaling pathway_Homo sapiens_hsa049220.43219479
88MAPK signaling pathway_Homo sapiens_hsa040100.41813780
89Huntingtons disease_Homo sapiens_hsa050160.40000087
90ABC transporters_Homo sapiens_hsa020100.39968326
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38401924
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38303786
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38141670
94Amoebiasis_Homo sapiens_hsa051460.37880409
95Thyroid hormone synthesis_Homo sapiens_hsa049180.37080876
96Axon guidance_Homo sapiens_hsa043600.36009058
97Choline metabolism in cancer_Homo sapiens_hsa052310.35545820
98HIF-1 signaling pathway_Homo sapiens_hsa040660.34801388
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34563728
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34234980
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34001457
102Arginine biosynthesis_Homo sapiens_hsa002200.33684068
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.32569312
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31155276
105Estrogen signaling pathway_Homo sapiens_hsa049150.30732002
106Basal cell carcinoma_Homo sapiens_hsa052170.27444902
107Regulation of autophagy_Homo sapiens_hsa041400.26243079
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25880948
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25470150
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24183750
111Purine metabolism_Homo sapiens_hsa002300.21326439
112Rheumatoid arthritis_Homo sapiens_hsa053230.19868479
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19211039
114AMPK signaling pathway_Homo sapiens_hsa041520.18396958
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.18091911
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17541144
117Glycerolipid metabolism_Homo sapiens_hsa005610.16751279
118Endocytosis_Homo sapiens_hsa041440.15255330
119ErbB signaling pathway_Homo sapiens_hsa040120.13803566
120Renal cell carcinoma_Homo sapiens_hsa052110.13048734
121Ras signaling pathway_Homo sapiens_hsa040140.12438666
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11540227
123Ovarian steroidogenesis_Homo sapiens_hsa049130.08847555
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06749518
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06171198

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