PLK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)4.79178461
2telomere maintenance via semi-conservative replication (GO:0032201)4.69145579
3DNA strand elongation involved in DNA replication (GO:0006271)4.67694495
4mitotic metaphase plate congression (GO:0007080)4.66560736
5DNA replication initiation (GO:0006270)4.63343628
6DNA ligation (GO:0006266)4.55872591
7DNA replication checkpoint (GO:0000076)4.49916139
8CENP-A containing nucleosome assembly (GO:0034080)4.48088625
9DNA strand elongation (GO:0022616)4.47153991
10protein localization to kinetochore (GO:0034501)4.43864679
11chromatin remodeling at centromere (GO:0031055)4.39988352
12kinetochore organization (GO:0051383)4.39557417
13telomere maintenance via recombination (GO:0000722)4.39064348
14establishment of integrated proviral latency (GO:0075713)4.30251137
15mitotic recombination (GO:0006312)4.20524651
16ribosome assembly (GO:0042255)4.17276708
17metaphase plate congression (GO:0051310)4.14632021
18chromosome condensation (GO:0030261)4.13767627
19kinetochore assembly (GO:0051382)4.11353902
20protein localization to chromosome, centromeric region (GO:0071459)4.04657442
21DNA replication-independent nucleosome assembly (GO:0006336)4.02939086
22DNA replication-independent nucleosome organization (GO:0034724)4.02939086
23attachment of spindle microtubules to kinetochore (GO:0008608)3.99413159
24DNA deamination (GO:0045006)3.95059527
25regulation of sister chromatid cohesion (GO:0007063)3.91117072
26mitotic nuclear envelope disassembly (GO:0007077)3.89354641
27DNA unwinding involved in DNA replication (GO:0006268)3.89012495
28establishment of chromosome localization (GO:0051303)3.87893925
29histone exchange (GO:0043486)3.80632741
30nuclear pore organization (GO:0006999)3.80329105
31mitotic sister chromatid segregation (GO:0000070)3.80274856
32telomere maintenance via telomere lengthening (GO:0010833)3.79488486
33regulation of DNA endoreduplication (GO:0032875)3.76329027
34DNA replication-dependent nucleosome organization (GO:0034723)3.75990408
35DNA replication-dependent nucleosome assembly (GO:0006335)3.75990408
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73510698
37microtubule depolymerization (GO:0007019)3.71748827
38nuclear pore complex assembly (GO:0051292)3.70806423
39non-recombinational repair (GO:0000726)3.69423211
40double-strand break repair via nonhomologous end joining (GO:0006303)3.69423211
41DNA packaging (GO:0006323)3.67126172
42protein K6-linked ubiquitination (GO:0085020)3.64694346
43meiotic chromosome segregation (GO:0045132)3.63358495
44mitotic chromosome condensation (GO:0007076)3.62886416
45membrane disassembly (GO:0030397)3.59066512
46nuclear envelope disassembly (GO:0051081)3.59066512
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.54349916
48nucleobase biosynthetic process (GO:0046112)3.52438139
49spindle checkpoint (GO:0031577)3.52000896
50DNA duplex unwinding (GO:0032508)3.49943197
51sister chromatid segregation (GO:0000819)3.48044899
52DNA conformation change (GO:0071103)3.47503641
53* regulation of centriole replication (GO:0046599)3.45708075
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.45430788
55regulation of double-strand break repair via homologous recombination (GO:0010569)3.45177665
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43043193
57DNA geometric change (GO:0032392)3.43040614
58regulation of spindle organization (GO:0090224)3.43002395
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41029517
60negative regulation of sister chromatid segregation (GO:0033046)3.41029517
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.41029517
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41029517
63negative regulation of chromosome segregation (GO:0051985)3.40442107
64mitotic G2/M transition checkpoint (GO:0044818)3.38241904
65purine nucleobase biosynthetic process (GO:0009113)3.37400729
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36666557
67spindle assembly checkpoint (GO:0071173)3.34730695
68ribosome biogenesis (GO:0042254)3.34114692
69regulation of chromosome segregation (GO:0051983)3.31742224
70heterochromatin organization (GO:0070828)3.31476371
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31287302
72mitotic spindle assembly checkpoint (GO:0007094)3.29440767
73DNA synthesis involved in DNA repair (GO:0000731)3.28274783
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28137338
75mitotic spindle checkpoint (GO:0071174)3.26983631
76proteasome assembly (GO:0043248)3.26752762
77maturation of 5.8S rRNA (GO:0000460)3.26631036
78negative regulation of mitosis (GO:0045839)3.25730563
79rRNA modification (GO:0000154)3.23773565
80establishment of viral latency (GO:0019043)3.18840946
81IMP biosynthetic process (GO:0006188)3.18384272
82regulation of mitotic sister chromatid separation (GO:0010965)3.17812581
83regulation of mitotic sister chromatid segregation (GO:0033047)3.17812581
84regulation of sister chromatid segregation (GO:0033045)3.17812581
85maturation of SSU-rRNA (GO:0030490)3.17138541
86ribosomal small subunit assembly (GO:0000028)3.16632853
87IMP metabolic process (GO:0046040)3.16174648
88protein complex localization (GO:0031503)3.15825114
89deoxyribonucleotide biosynthetic process (GO:0009263)3.14136610
90positive regulation of chromosome segregation (GO:0051984)3.12974313
91formation of translation preinitiation complex (GO:0001731)3.12527322
92transcription-coupled nucleotide-excision repair (GO:0006283)3.12201964
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11374162
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.11374162
95protein localization to chromosome (GO:0034502)3.11303907
96nuclear envelope organization (GO:0006998)3.10618398
97chromosome segregation (GO:0007059)3.10506040
98chromatin assembly or disassembly (GO:0006333)3.10211202
99chromosome organization (GO:0051276)3.07112930
100telomere maintenance (GO:0000723)3.05488167
101spliceosomal snRNP assembly (GO:0000387)3.05299051
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04304771
103ribonucleoprotein complex biogenesis (GO:0022613)3.04188747
104telomere organization (GO:0032200)3.04077034
105folic acid-containing compound biosynthetic process (GO:0009396)3.00881010
106ATP-dependent chromatin remodeling (GO:0043044)3.00092418
107DNA-dependent DNA replication (GO:0006261)2.99774537
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98214223
109mitotic sister chromatid cohesion (GO:0007064)2.96832528
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96302842
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96302842
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.96302842
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95242015
114* regulation of centrosome cycle (GO:0046605)2.93509375
115DNA replication (GO:0006260)2.93271272
116pore complex assembly (GO:0046931)2.91774643
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91608065
118mismatch repair (GO:0006298)2.91319090
119ribosomal large subunit biogenesis (GO:0042273)2.90249407
120regulation of mitotic spindle organization (GO:0060236)2.89788302
121rRNA processing (GO:0006364)2.88133061
122* mitotic cell cycle (GO:0000278)2.87535794
123G1/S transition of mitotic cell cycle (GO:0000082)2.87522510
124cell cycle G1/S phase transition (GO:0044843)2.87522510
125DNA double-strand break processing (GO:0000729)2.87296864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.28841899
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.92232790
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.30730069
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.01156465
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67742946
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33838945
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14334711
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.02233620
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.92397817
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83885367
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82157293
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77735580
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73236213
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.69277566
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66716923
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59617887
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43237343
18AR_21909140_ChIP-Seq_LNCAP_Human2.38992469
19* VDR_23849224_ChIP-Seq_CD4+_Human2.29392458
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22888820
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.21184234
22XRN2_22483619_ChIP-Seq_HELA_Human2.20626929
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17729320
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12457013
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01566941
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98698180
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94297760
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94227504
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92119342
30FOXP3_21729870_ChIP-Seq_TREG_Human1.91594101
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90772876
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88559178
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87203039
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86431105
35DCP1A_22483619_ChIP-Seq_HELA_Human1.83386327
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.79593670
37TTF2_22483619_ChIP-Seq_HELA_Human1.77658592
38* GABP_19822575_ChIP-Seq_HepG2_Human1.76623781
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.69422195
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67538310
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64267650
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64266232
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63056010
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59771909
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.57089928
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53861469
47CIITA_25753668_ChIP-Seq_RAJI_Human1.52048659
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50997081
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44127545
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42294737
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.41164281
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39755441
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.39269721
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37720453
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36685880
56KDM5A_27292631_Chip-Seq_BREAST_Human1.36601025
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35386852
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31340336
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27544113
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24007337
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22493581
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19623707
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19552241
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18200494
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17849880
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16364547
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14768113
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13426705
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13181157
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09538133
71MYC_18940864_ChIP-ChIP_HL60_Human1.09434920
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09279784
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08269632
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.05680826
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.04369575
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03624097
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03593783
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.02811219
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02562946
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98706136
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97388654
82MYC_22102868_ChIP-Seq_BL_Human0.97233201
83* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96577217
84TFEB_21752829_ChIP-Seq_HELA_Human0.94855619
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89331567
86SPI1_23547873_ChIP-Seq_NB4_Human0.88522966
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87545407
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84298428
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82800709
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82021453
91EWS_26573619_Chip-Seq_HEK293_Human0.81323285
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.80634470
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79559090
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.79310108
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79171139
96CHD1_26751641_Chip-Seq_LNCaP_Human0.76405126
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76143567
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75896149
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74611630
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73223980
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72058411
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71788310
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71656096
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70828357
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70249541
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69790946
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.69249352
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68532711
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.67639049
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67411452
111IRF1_19129219_ChIP-ChIP_H3396_Human0.63446693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52821203
2MP0010094_abnormal_chromosome_stability4.80379146
3MP0003111_abnormal_nucleus_morphology4.61636822
4MP0003077_abnormal_cell_cycle4.06303349
5MP0004957_abnormal_blastocyst_morpholog4.01299032
6MP0008057_abnormal_DNA_replication3.90045655
7MP0008058_abnormal_DNA_repair3.45845604
8MP0008007_abnormal_cellular_replicative3.08488783
9MP0008877_abnormal_DNA_methylation2.83832736
10MP0008932_abnormal_embryonic_tissue2.77260587
11MP0003123_paternal_imprinting2.50087177
12MP0003718_maternal_effect2.32013450
13MP0003786_premature_aging2.07729694
14MP0000350_abnormal_cell_proliferation2.03252617
15MP0001730_embryonic_growth_arrest2.02803772
16MP0002396_abnormal_hematopoietic_system1.89091786
17MP0010307_abnormal_tumor_latency1.87835769
18MP0010352_gastrointestinal_tract_polyps1.87818463
19MP0000490_abnormal_crypts_of1.63037560
20MP0005380_embryogenesis_phenotype1.61470599
21MP0001672_abnormal_embryogenesis/_devel1.61470599
22MP0002210_abnormal_sex_determination1.60340059
23MP0003121_genomic_imprinting1.57945937
24* MP0001697_abnormal_embryo_size1.53492930
25MP0002160_abnormal_reproductive_system1.44027453
26* MP0002085_abnormal_embryonic_tissue1.41517380
27MP0006292_abnormal_olfactory_placode1.40977080
28* MP0000313_abnormal_cell_death1.39382761
29MP0003984_embryonic_growth_retardation1.38768007
30MP0001929_abnormal_gametogenesis1.38515247
31MP0004808_abnormal_hematopoietic_stem1.36885587
32MP0002009_preneoplasia1.36200204
33MP0002877_abnormal_melanocyte_morpholog1.36085153
34* MP0002080_prenatal_lethality1.35978379
35MP0003315_abnormal_perineum_morphology1.35840000
36MP0001145_abnormal_male_reproductive1.35807165
37MP0002019_abnormal_tumor_incidence1.35329403
38MP0002088_abnormal_embryonic_growth/wei1.35215387
39MP0010030_abnormal_orbit_morphology1.32814697
40MP0000653_abnormal_sex_gland1.27030628
41MP0001119_abnormal_female_reproductive1.27013582
42MP0005389_reproductive_system_phenotype1.26835648
43MP0002084_abnormal_developmental_patter1.24258711
44MP0002102_abnormal_ear_morphology1.22880587
45MP0002086_abnormal_extraembryonic_tissu1.18883817
46MP0003941_abnormal_skin_development1.18153413
47MP0002697_abnormal_eye_size1.17233308
48MP0003890_abnormal_embryonic-extraembry1.17151473
49MP0004197_abnormal_fetal_growth/weight/1.15690370
50MP0001293_anophthalmia1.14683825
51MP0006035_abnormal_mitochondrial_morpho1.11972513
52MP0003567_abnormal_fetal_cardiomyocyte1.11099852
53MP0000703_abnormal_thymus_morphology1.07762528
54MP0009333_abnormal_splenocyte_physiolog1.07626342
55MP0003763_abnormal_thymus_physiology1.07454153
56MP0003937_abnormal_limbs/digits/tail_de1.02713095
57MP0005397_hematopoietic_system_phenotyp1.00976914
58MP0001545_abnormal_hematopoietic_system1.00976914
59MP0001919_abnormal_reproductive_system0.98384857
60MP0005076_abnormal_cell_differentiation0.97857032
61MP0004147_increased_porphyrin_level0.96207398
62MP0002398_abnormal_bone_marrow0.94542450
63MP0000537_abnormal_urethra_morphology0.94132787
64MP0001853_heart_inflammation0.93689585
65MP0001346_abnormal_lacrimal_gland0.92361149
66MP0002722_abnormal_immune_system0.91668785
67MP0004185_abnormal_adipocyte_glucose0.91311261
68MP0000689_abnormal_spleen_morphology0.89631256
69MP0002092_abnormal_eye_morphology0.84765033
70MP0000858_altered_metastatic_potential0.84238525
71MP0002233_abnormal_nose_morphology0.84221058
72MP0003221_abnormal_cardiomyocyte_apopto0.83672326
73MP0000566_synostosis0.82820056
74MP0003186_abnormal_redox_activity0.82023721
75MP0004133_heterotaxia0.81457927
76MP0002111_abnormal_tail_morphology0.80925834
77MP0003787_abnormal_imprinting0.80294083
78MP0005395_other_phenotype0.79434476
79MP0002653_abnormal_ependyma_morphology0.77527932
80MP0003698_abnormal_male_reproductive0.77094631
81MP0002132_abnormal_respiratory_system0.76847709
82* MP0005384_cellular_phenotype0.75639706
83* MP0003861_abnormal_nervous_system0.75145915
84MP0001915_intracranial_hemorrhage0.74327957
85MP0001286_abnormal_eye_development0.74085678
86MP0001529_abnormal_vocalization0.73579500
87MP0003699_abnormal_female_reproductive0.73349944
88MP0003705_abnormal_hypodermis_morpholog0.72780561
89MP0003943_abnormal_hepatobiliary_system0.72287211
90MP0005501_abnormal_skin_physiology0.71894476
91MP0002429_abnormal_blood_cell0.71354077
92MP0006072_abnormal_retinal_apoptosis0.71093120
93* MP0005621_abnormal_cell_physiology0.70230778
94MP0001661_extended_life_span0.69882084
95MP0000358_abnormal_cell_content/0.68121303
96MP0009053_abnormal_anal_canal0.67825914
97MP0009672_abnormal_birth_weight0.67620960
98MP0003935_abnormal_craniofacial_develop0.66878716
99MP0000647_abnormal_sebaceous_gland0.66602065
100MP0008789_abnormal_olfactory_epithelium0.66257498
101MP0002938_white_spotting0.66220140
102MP0003385_abnormal_body_wall0.66069098
103MP0010234_abnormal_vibrissa_follicle0.65603755
104MP0002095_abnormal_skin_pigmentation0.65178159
105MP0005408_hypopigmentation0.65080900
106MP0008995_early_reproductive_senescence0.65036605
107MP0000432_abnormal_head_morphology0.64761806
108MP0003448_altered_tumor_morphology0.64565630
109MP0001727_abnormal_embryo_implantation0.64478534
110MP0002161_abnormal_fertility/fecundity0.64352478
111MP0003119_abnormal_digestive_system0.64221228
112MP0003936_abnormal_reproductive_system0.62899923
113MP0002075_abnormal_coat/hair_pigmentati0.62580807
114MP0000716_abnormal_immune_system0.61418116
115MP0006036_abnormal_mitochondrial_physio0.59665674
116MP0005023_abnormal_wound_healing0.59464677
117MP0001186_pigmentation_phenotype0.59289366
118MP0003806_abnormal_nucleotide_metabolis0.58280797
119MP0009703_decreased_birth_body0.57819251
120MP0002277_abnormal_respiratory_mucosa0.57161643
121MP0000428_abnormal_craniofacial_morphol0.56320622
122MP0000627_abnormal_mammary_gland0.55476601
123MP0009697_abnormal_copulation0.55458737
124MP0006054_spinal_hemorrhage0.55077773
125MP0003656_abnormal_erythrocyte_physiolo0.55052872
126MP0003755_abnormal_palate_morphology0.52941204
127MP0000049_abnormal_middle_ear0.52561815
128MP0005499_abnormal_olfactory_system0.51649516
129MP0005394_taste/olfaction_phenotype0.51649516
130MP0005391_vision/eye_phenotype0.50926097
131MP0008770_decreased_survivor_rate0.50519729

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.24500471
2Chromsome breakage (HP:0040012)4.82035085
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70329225
4Breast hypoplasia (HP:0003187)4.48355935
5Abnormality of chromosome stability (HP:0003220)3.70191776
6Meckel diverticulum (HP:0002245)3.69642356
7Patellar aplasia (HP:0006443)3.66328414
8Aplasia/Hypoplasia of the patella (HP:0006498)3.50963765
9Abnormality of the ileum (HP:0001549)3.47248564
10Carpal bone hypoplasia (HP:0001498)3.45704952
11Cortical dysplasia (HP:0002539)3.44786226
12Abnormality of the preputium (HP:0100587)3.33982813
13Reticulocytopenia (HP:0001896)3.27202829
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.24887597
15Volvulus (HP:0002580)3.23794437
16Selective tooth agenesis (HP:0001592)3.00192135
17Oral leukoplakia (HP:0002745)2.99557982
18Impulsivity (HP:0100710)2.99088308
19Ectopic kidney (HP:0000086)2.94885283
20Small intestinal stenosis (HP:0012848)2.90638746
21Duodenal stenosis (HP:0100867)2.90638746
22Absent radius (HP:0003974)2.87312443
23Colon cancer (HP:0003003)2.83785706
24Medulloblastoma (HP:0002885)2.82977568
25Myelodysplasia (HP:0002863)2.80092981
26Aplastic anemia (HP:0001915)2.79477122
27Rough bone trabeculation (HP:0100670)2.71581572
28Supernumerary spleens (HP:0009799)2.69057656
29Aplasia involving forearm bones (HP:0009822)2.68620674
30Absent forearm bone (HP:0003953)2.68620674
31Abnormal lung lobation (HP:0002101)2.64184395
32Bone marrow hypocellularity (HP:0005528)2.60153624
33Absent thumb (HP:0009777)2.59297302
34Sloping forehead (HP:0000340)2.54037337
35Abnormality of the anterior horn cell (HP:0006802)2.52469737
36Degeneration of anterior horn cells (HP:0002398)2.52469737
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46704936
38Premature graying of hair (HP:0002216)2.43739898
39Abnormal number of erythroid precursors (HP:0012131)2.41658789
40Agnosia (HP:0010524)2.41489147
41Abnormality of cells of the erythroid lineage (HP:0012130)2.40942307
42Duplicated collecting system (HP:0000081)2.36908399
43Abnormality of the carotid arteries (HP:0005344)2.34818534
44Embryonal neoplasm (HP:0002898)2.34676487
45Abnormality of the duodenum (HP:0002246)2.33566260
46Clubbing of toes (HP:0100760)2.31216891
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30515679
48Neoplasm of the pancreas (HP:0002894)2.30219810
49Tracheoesophageal fistula (HP:0002575)2.26626465
50Triphalangeal thumb (HP:0001199)2.24264961
51Abnormality of cochlea (HP:0000375)2.22239457
52Short thumb (HP:0009778)2.20752159
53Abnormality of the renal collecting system (HP:0004742)2.20377621
54Microretrognathia (HP:0000308)2.17536041
55Progressive external ophthalmoplegia (HP:0000590)2.17453848
56Choanal atresia (HP:0000453)2.17217338
57Horseshoe kidney (HP:0000085)2.15964122
58Abnormality of chromosome segregation (HP:0002916)2.15489985
5911 pairs of ribs (HP:0000878)2.15437768
60Cellular immunodeficiency (HP:0005374)2.15172858
61Arteriovenous malformation (HP:0100026)2.15005997
62Microvesicular hepatic steatosis (HP:0001414)2.14984479
63Abnormality of the labia minora (HP:0012880)2.14185259
64Cleft eyelid (HP:0000625)2.13060647
65Increased nuchal translucency (HP:0010880)2.09982603
66Deep philtrum (HP:0002002)2.09399042
67Proximal placement of thumb (HP:0009623)2.07863560
68Premature ovarian failure (HP:0008209)2.07766393
69Multiple enchondromatosis (HP:0005701)2.07626430
70Nephroblastoma (Wilms tumor) (HP:0002667)2.05305479
71Squamous cell carcinoma (HP:0002860)2.03823950
72Atresia of the external auditory canal (HP:0000413)2.03403369
73Granulocytopenia (HP:0001913)2.03307609
74Abnormal trabecular bone morphology (HP:0100671)2.03179578
75Abnormal spermatogenesis (HP:0008669)2.02532173
76Rhabdomyosarcoma (HP:0002859)1.99817514
77Deviation of the thumb (HP:0009603)1.98928421
78Secondary amenorrhea (HP:0000869)1.97887573
79Abnormality of glycolysis (HP:0004366)1.97669257
80Cerebral hypomyelination (HP:0006808)1.96746417
81Breast aplasia (HP:0100783)1.95438775
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.93968715
83High pitched voice (HP:0001620)1.92444689
84Embryonal renal neoplasm (HP:0011794)1.91271381
85Overlapping toe (HP:0001845)1.90065108
86Aplasia/Hypoplasia of the breasts (HP:0010311)1.89901900
87Duplication of thumb phalanx (HP:0009942)1.89421370
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87985419
89Increased serum pyruvate (HP:0003542)1.87358870
90Abnormality of abdominal situs (HP:0011620)1.86914731
91Abdominal situs inversus (HP:0003363)1.86914731
92Abnormal number of incisors (HP:0011064)1.86234445
93Pallor (HP:0000980)1.86007968
94Missing ribs (HP:0000921)1.85596796
95High anterior hairline (HP:0009890)1.84929477
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83844560
97Ependymoma (HP:0002888)1.82829880
98Glioma (HP:0009733)1.82459384
99Facial cleft (HP:0002006)1.82379480
100Lymphoma (HP:0002665)1.80745068
101Neoplasm of the colon (HP:0100273)1.80222852
102Type 2 muscle fiber atrophy (HP:0003554)1.80097107
103Macrocytic anemia (HP:0001972)1.79771705
104Muscle fiber atrophy (HP:0100295)1.78590879
105Neoplasm of the oral cavity (HP:0100649)1.78565129
106Cafe-au-lait spot (HP:0000957)1.76876799
107Facial hemangioma (HP:0000329)1.75952678
108Abnormality of the astrocytes (HP:0100707)1.74324693
109Astrocytoma (HP:0009592)1.74324693
110Pulmonary fibrosis (HP:0002206)1.74202187
111Capillary hemangiomas (HP:0005306)1.74102418
112Malignant gastrointestinal tract tumors (HP:0006749)1.72929973
113Gastrointestinal carcinoma (HP:0002672)1.72929973
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72748759
115Aplasia/hypoplasia of the humerus (HP:0006507)1.72408704
116Ovarian neoplasm (HP:0100615)1.72225921
117Optic nerve coloboma (HP:0000588)1.72225078
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71666700
119Short 4th metacarpal (HP:0010044)1.71666700
120Irregular epiphyses (HP:0010582)1.71560150
121Abnormality of DNA repair (HP:0003254)1.70626841
122Slender long bone (HP:0003100)1.70478679
123Hypoplasia of the radius (HP:0002984)1.68919080
124Short middle phalanx of the 5th finger (HP:0004220)1.67855557
125Acute lymphatic leukemia (HP:0006721)1.67510161
126Neoplasm of the adrenal cortex (HP:0100641)1.66463690
127Acute myeloid leukemia (HP:0004808)1.65926643
128Trismus (HP:0000211)1.65823054
129Leiomyosarcoma (HP:0100243)1.65739645
130Uterine leiomyosarcoma (HP:0002891)1.65739645
131Neoplasm of striated muscle (HP:0009728)1.65081573
132Progressive muscle weakness (HP:0003323)1.63660355
133Abnormality of the fetal cardiovascular system (HP:0010948)1.61684500
134Abnormal umbilical cord blood vessels (HP:0011403)1.61684500
135Single umbilical artery (HP:0001195)1.61684500
136Sandal gap (HP:0001852)1.59850643
137Morphological abnormality of the inner ear (HP:0011390)1.58671360
138Breast carcinoma (HP:0003002)1.58435722
139Microglossia (HP:0000171)1.57980205
140Uterine neoplasm (HP:0010784)1.55173460
141Hypoplastic pelvis (HP:0008839)1.54266423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14062035
2CDC74.32593421
3WEE14.07699519
4TTK3.10136055
5SRPK12.94568118
6NEK22.88308997
7EIF2AK12.84442639
8ZAK2.79891571
9IRAK32.74521103
10PLK12.23329416
11STK162.17858277
12NEK12.06578634
13BRSK21.88789368
14ATR1.85013199
15VRK21.83942873
16ACVR1B1.83709104
17PLK31.83399949
18VRK11.83127755
19AURKB1.72452105
20CHEK21.71707657
21* PLK41.70413624
22TESK21.67312068
23EIF2AK31.64108746
24MKNK11.64007894
25TAF11.63907539
26TSSK61.63269663
27RPS6KB21.59431157
28DYRK31.55018591
29IRAK41.54307999
30MST41.54161909
31TLK11.46824016
32CDK71.43687038
33EPHA21.43481110
34RPS6KA41.42815069
35STK41.37965444
36TRIM281.32391073
37MKNK21.28400093
38CCNB11.26978980
39MAP3K81.26031423
40STK38L1.26018342
41BRSK11.21344274
42STK101.21028664
43CHEK11.19833074
44AURKA1.18698803
45SMG11.06908299
46PAK41.04276434
47BRAF1.03575029
48NME21.00983360
49CDK41.00660582
50CDK121.00199466
51LATS10.99767000
52STK30.98790294
53ATM0.97763060
54PASK0.97516321
55TESK10.88370080
56EIF2AK20.85493050
57BRD40.84822926
58PIM10.81534304
59MAPKAPK30.81138251
60BCR0.80544329
61CDK20.77025222
62LATS20.73228541
63IRAK20.71225300
64CDK80.71162067
65MELK0.70512662
66KDR0.68675368
67IRAK10.68076452
68ALK0.66633705
69EEF2K0.64956964
70PBK0.64562229
71CDK10.61880138
72PRKCI0.61633008
73SCYL20.60554060
74CSNK2A10.58918362
75TNIK0.58506012
76RPS6KA50.57064230
77ERBB40.56121300
78TGFBR10.55960581
79AKT30.55940953
80PNCK0.51390491
81PAK10.51226798
82MARK10.51065540
83CDK90.49428141
84CDK180.47564314
85CDK30.47467175
86NEK90.47249067
87CSNK2A20.46631872
88DYRK20.45855643
89MAP3K100.45490158
90RAF10.45468736
91CDK150.44095022
92CDK60.43037770
93CDK11A0.42851583
94WNK30.41397597
95MST1R0.40682569
96PIM20.40394318
97NME10.39953417
98ERBB30.39740138
99PLK20.39567873
100MAP4K10.39001126
101CDK140.38547718
102FLT30.38434978
103FGFR10.37356595
104PINK10.35370513
105KSR10.34350219
106MET0.33259100
107BMPR20.32461078
108AKT20.32457544
109CSNK1E0.32348476
110MAP3K110.31616393
111CHUK0.31057086
112ABL20.29747742
113CLK10.29403647
114PRKDC0.28362761
115IKBKB0.27676803
116JAK30.26768373
117STK240.26598293
118YES10.26400519
119PDK40.25172294
120PDK30.25172294
121TEC0.22697225
122MAPK140.22659366
123TXK0.22249370
124BMPR1B0.21414604
125MARK30.21385219
126NUAK10.20898611
127LRRK20.19524777
128GSK3B0.19485365
129SIK30.19306609
130BMX0.16879857
131CSNK1G10.16303167

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11126340
2Mismatch repair_Homo sapiens_hsa034304.18744043
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50174649
4RNA polymerase_Homo sapiens_hsa030203.32747894
5Homologous recombination_Homo sapiens_hsa034403.28965394
6Spliceosome_Homo sapiens_hsa030403.10260645
7Base excision repair_Homo sapiens_hsa034103.08559045
8Cell cycle_Homo sapiens_hsa041103.06079434
9Proteasome_Homo sapiens_hsa030503.05067447
10RNA transport_Homo sapiens_hsa030132.96199939
11Fanconi anemia pathway_Homo sapiens_hsa034602.95118116
12Nucleotide excision repair_Homo sapiens_hsa034202.83865588
13Ribosome_Homo sapiens_hsa030102.75540011
14Pyrimidine metabolism_Homo sapiens_hsa002402.62562801
15One carbon pool by folate_Homo sapiens_hsa006702.46101102
16Basal transcription factors_Homo sapiens_hsa030222.23367219
17RNA degradation_Homo sapiens_hsa030182.21194215
18Non-homologous end-joining_Homo sapiens_hsa034502.17721150
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01646722
20p53 signaling pathway_Homo sapiens_hsa041151.93972315
21mRNA surveillance pathway_Homo sapiens_hsa030151.56540600
22Purine metabolism_Homo sapiens_hsa002301.45254774
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38263787
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37941396
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35956885
26Epstein-Barr virus infection_Homo sapiens_hsa051691.34358597
27Systemic lupus erythematosus_Homo sapiens_hsa053221.33052580
28Pyruvate metabolism_Homo sapiens_hsa006201.11146143
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08669991
30Steroid biosynthesis_Homo sapiens_hsa001001.07998456
31Herpes simplex infection_Homo sapiens_hsa051681.06963148
32Oocyte meiosis_Homo sapiens_hsa041141.04843453
33Viral carcinogenesis_Homo sapiens_hsa052031.00585084
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96601902
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96044934
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95674834
37Carbon metabolism_Homo sapiens_hsa012000.94696978
38Propanoate metabolism_Homo sapiens_hsa006400.83824280
39HTLV-I infection_Homo sapiens_hsa051660.83430549
40Lysine degradation_Homo sapiens_hsa003100.77872582
41Antigen processing and presentation_Homo sapiens_hsa046120.77652003
42Vitamin B6 metabolism_Homo sapiens_hsa007500.75058508
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.73834294
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73686502
45Small cell lung cancer_Homo sapiens_hsa052220.64721739
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.64325869
47MicroRNAs in cancer_Homo sapiens_hsa052060.64219254
48Folate biosynthesis_Homo sapiens_hsa007900.63154756
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62799389
50Pentose phosphate pathway_Homo sapiens_hsa000300.60900587
51Legionellosis_Homo sapiens_hsa051340.59220264
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58058079
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55974049
54TGF-beta signaling pathway_Homo sapiens_hsa043500.55555504
55Huntingtons disease_Homo sapiens_hsa050160.55291078
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54136985
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53989970
58Primary immunodeficiency_Homo sapiens_hsa053400.52709967
59Measles_Homo sapiens_hsa051620.52014215
60Fatty acid elongation_Homo sapiens_hsa000620.51590925
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50636386
62Apoptosis_Homo sapiens_hsa042100.50443454
63Glutathione metabolism_Homo sapiens_hsa004800.48907853
64Selenocompound metabolism_Homo sapiens_hsa004500.48000443
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.46554958
66Hepatitis B_Homo sapiens_hsa051610.44386278
67Thyroid cancer_Homo sapiens_hsa052160.43925880
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.43883021
69Protein export_Homo sapiens_hsa030600.43122103
70Shigellosis_Homo sapiens_hsa051310.42799862
71Alcoholism_Homo sapiens_hsa050340.41105531
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41094469
73Colorectal cancer_Homo sapiens_hsa052100.40358183
74Wnt signaling pathway_Homo sapiens_hsa043100.38676869
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38438158
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36935554
77Hippo signaling pathway_Homo sapiens_hsa043900.36908120
78Biosynthesis of amino acids_Homo sapiens_hsa012300.35241842
79Influenza A_Homo sapiens_hsa051640.34693921
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34057655
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33544005
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32868265
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32519949
84Hematopoietic cell lineage_Homo sapiens_hsa046400.31849118
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30938678
86Arachidonic acid metabolism_Homo sapiens_hsa005900.30682763
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.30626670
88Parkinsons disease_Homo sapiens_hsa050120.28957817
89Basal cell carcinoma_Homo sapiens_hsa052170.28647175
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27458319
91Fatty acid metabolism_Homo sapiens_hsa012120.26719068
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26649119
93N-Glycan biosynthesis_Homo sapiens_hsa005100.25854218
94Notch signaling pathway_Homo sapiens_hsa043300.25718903
95Non-small cell lung cancer_Homo sapiens_hsa052230.25159836
96Pathways in cancer_Homo sapiens_hsa052000.25036861
97Allograft rejection_Homo sapiens_hsa053300.24687574
98Leishmaniasis_Homo sapiens_hsa051400.22879607
99Asthma_Homo sapiens_hsa053100.21822036
100Renin-angiotensin system_Homo sapiens_hsa046140.21457895
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21227247
102Chronic myeloid leukemia_Homo sapiens_hsa052200.20120774
103Graft-versus-host disease_Homo sapiens_hsa053320.19860161
104Pancreatic cancer_Homo sapiens_hsa052120.19761126
105HIF-1 signaling pathway_Homo sapiens_hsa040660.19757482
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.19493076
107Prostate cancer_Homo sapiens_hsa052150.18124965
108Hedgehog signaling pathway_Homo sapiens_hsa043400.16984234
109Linoleic acid metabolism_Homo sapiens_hsa005910.16549199
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15972672
111Adherens junction_Homo sapiens_hsa045200.15951501
112Viral myocarditis_Homo sapiens_hsa054160.15875036
113Metabolic pathways_Homo sapiens_hsa011000.15531068
114Acute myeloid leukemia_Homo sapiens_hsa052210.15245488
115Endometrial cancer_Homo sapiens_hsa052130.15090933
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.13067417
117Fructose and mannose metabolism_Homo sapiens_hsa000510.12219849
118Other glycan degradation_Homo sapiens_hsa005110.12217010
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11301712
120Autoimmune thyroid disease_Homo sapiens_hsa053200.10811213
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10775356
122Bladder cancer_Homo sapiens_hsa052190.10665769
123Sulfur relay system_Homo sapiens_hsa041220.10655862
124Melanoma_Homo sapiens_hsa052180.10518815
125Glioma_Homo sapiens_hsa052140.06880113
126Tight junction_Homo sapiens_hsa045300.05299102
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04100739
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03561501
129Proteoglycans in cancer_Homo sapiens_hsa052050.03560640

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