PLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrioventricular valve morphogenesis (GO:0003181)4.08956373
2positive regulation of odontogenesis (GO:0042482)3.98141259
3regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.81329728
4positive regulation of osteoblast proliferation (GO:0033690)3.81007987
5endothelium development (GO:0003158)3.67987061
6ER overload response (GO:0006983)3.58049561
7desmosome organization (GO:0002934)3.56684396
8hemidesmosome assembly (GO:0031581)3.53997286
9neuron projection extension involved in neuron projection guidance (GO:1902284)3.50466266
10axon extension involved in axon guidance (GO:0048846)3.50466266
11cell migration involved in sprouting angiogenesis (GO:0002042)3.29821225
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.26808052
13hepatocyte differentiation (GO:0070365)3.25879789
14nodal signaling pathway (GO:0038092)3.25612847
15positive regulation of p38MAPK cascade (GO:1900745)3.25388687
16pericardium development (GO:0060039)3.24783067
17negative regulation of chondrocyte differentiation (GO:0032331)3.23248148
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23054802
19negative regulation of keratinocyte proliferation (GO:0010839)3.20023351
20morphogenesis of an epithelial sheet (GO:0002011)3.19817712
21substrate-dependent cell migration (GO:0006929)3.19662887
22wound healing, spreading of epidermal cells (GO:0035313)3.16224353
23hippo signaling (GO:0035329)3.14891235
24negative regulation of amino acid transport (GO:0051956)3.13283600
25basement membrane organization (GO:0071711)3.11143319
26keratinocyte development (GO:0003334)3.06860308
27endothelial cell morphogenesis (GO:0001886)3.05426993
28vocalization behavior (GO:0071625)3.02188501
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.01068230
30endocardial cushion morphogenesis (GO:0003203)2.99190028
31regulation of glutamate receptor signaling pathway (GO:1900449)2.98256219
32midgut development (GO:0007494)2.97744535
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97514707
34notochord development (GO:0030903)2.94997405
35positive regulation of astrocyte differentiation (GO:0048711)2.90995512
36Golgi transport vesicle coating (GO:0048200)2.90776158
37COPI coating of Golgi vesicle (GO:0048205)2.90776158
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90286670
39protein prenylation (GO:0018342)2.89555919
40prenylation (GO:0097354)2.89555919
41negative regulation of hormone biosynthetic process (GO:0032353)2.89512082
42gap junction assembly (GO:0016264)2.86568444
43synaptic vesicle docking involved in exocytosis (GO:0016081)2.86154522
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82864277
45regulation of cell proliferation involved in kidney development (GO:1901722)2.81745709
46cell adhesion mediated by integrin (GO:0033627)2.81424098
47branching involved in salivary gland morphogenesis (GO:0060445)2.80678379
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79273269
49regulation of dendritic spine morphogenesis (GO:0061001)2.77774784
50regulation of cell communication by electrical coupling (GO:0010649)2.77748621
51positive regulation of cartilage development (GO:0061036)2.77537427
52cell surface receptor signaling pathway involved in heart development (GO:0061311)2.75681786
53regulation of hippo signaling (GO:0035330)2.75293656
54lymph vessel development (GO:0001945)2.75180805
55regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73528270
56regulation of synapse structural plasticity (GO:0051823)2.72405086
57protein localization to synapse (GO:0035418)2.72186693
58polarized epithelial cell differentiation (GO:0030859)2.71596573
59smooth muscle tissue development (GO:0048745)2.71477945
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69439136
61regulation of cardiac muscle cell contraction (GO:0086004)2.69086942
62neural crest cell development (GO:0014032)2.69082750
63lung vasculature development (GO:0060426)2.68358228
64heart valve morphogenesis (GO:0003179)2.67590549
65vascular endothelial growth factor signaling pathway (GO:0038084)2.67207474
66glutamate receptor signaling pathway (GO:0007215)2.64715560
67glutamate secretion (GO:0014047)2.64262172
68synaptic vesicle exocytosis (GO:0016079)2.63473584
69positive regulation of cardiac muscle cell differentiation (GO:2000727)2.62896964
70regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62498802
71dorsal/ventral axis specification (GO:0009950)2.61423990
72negative regulation of complement activation (GO:0045916)2.60830535
73positive regulation of heat generation (GO:0031652)2.60611961
74synaptic vesicle maturation (GO:0016188)2.60118261
75negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.59590039
76Notch signaling involved in heart development (GO:0061314)2.58107423
77pathway-restricted SMAD protein phosphorylation (GO:0060389)2.57241956
78negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.57035031
79homocysteine metabolic process (GO:0050667)2.56756803
80positive regulation of macrophage cytokine production (GO:0060907)2.56706413
81axonal fasciculation (GO:0007413)2.56211897
82ganglion development (GO:0061548)2.55372314
83clathrin coat assembly (GO:0048268)2.55316609
84regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.53821163
85locomotory exploration behavior (GO:0035641)2.53733481
86regulation of neuronal synaptic plasticity (GO:0048168)2.53304535
87blood vessel endothelial cell migration (GO:0043534)2.52916509
88regulation of fever generation (GO:0031620)2.51836488
89fibroblast migration (GO:0010761)2.51758604
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.51331409
91iron ion import (GO:0097286)2.51094033
92neuron recognition (GO:0008038)2.50848340
93endothelial cell chemotaxis (GO:0035767)2.50785863
94negative regulation of hormone metabolic process (GO:0032351)2.50392445
95glomerular visceral epithelial cell development (GO:0072015)2.47954263
96positive regulation of synapse maturation (GO:0090129)2.47467392
97negative regulation of dendrite morphogenesis (GO:0050774)2.46106401
98lymphangiogenesis (GO:0001946)2.45939774
99positive regulation of fibroblast migration (GO:0010763)2.45928052
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45782378
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.45782378
102modulation by symbiont of host immune response (GO:0052553)2.45782378
103positive regulation by symbiont of host defense response (GO:0052509)2.45782378
104modulation by symbiont of host defense response (GO:0052031)2.45782378
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45782378
106cell proliferation involved in kidney development (GO:0072111)2.45703828
107embryonic cranial skeleton morphogenesis (GO:0048701)2.45086802
108regulation of glutamate secretion (GO:0014048)2.44578847
109regulation of transforming growth factor beta2 production (GO:0032909)2.43558358
110mesenchyme morphogenesis (GO:0072132)2.42875390
111regulation of excitatory postsynaptic membrane potential (GO:0060079)2.41858675
112* regulation of synaptic plasticity (GO:0048167)2.41161910
113regulation of relaxation of muscle (GO:1901077)2.40792751
114regulation of glucocorticoid metabolic process (GO:0031943)2.40582673
115establishment of apical/basal cell polarity (GO:0035089)2.40482750
116cardiac epithelial to mesenchymal transition (GO:0060317)2.39490975
117regulation of cardioblast differentiation (GO:0051890)2.39453405
118epithelial cell-cell adhesion (GO:0090136)2.38799090
119signal complex assembly (GO:0007172)2.38281639
120positive regulation of vesicle fusion (GO:0031340)2.37055139
121synaptic transmission, glutamatergic (GO:0035249)2.36863603
122macrophage activation (GO:0042116)2.36414386
123regulation of synaptic vesicle exocytosis (GO:2000300)2.36051046
124zinc ion transmembrane transport (GO:0071577)2.35302584
125cellular zinc ion homeostasis (GO:0006882)2.34927402
126positive regulation of epithelial to mesenchymal transition (GO:0010718)2.34816608
127activation of MAPKKK activity (GO:0000185)2.34194908
128cell-substrate junction assembly (GO:0007044)2.34008250
129activin receptor signaling pathway (GO:0032924)2.33599282
130renal filtration (GO:0097205)2.32466506
131negative regulation of organic acid transport (GO:0032891)2.32390079
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32180616
133regulation of dendritic spine development (GO:0060998)2.32096789
134regulation of synapse maturation (GO:0090128)2.31853019
135axon extension (GO:0048675)2.31827166
136kidney mesenchyme development (GO:0072074)2.31701956
137regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.31571750
138cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30793414
139negative regulation of mast cell activation (GO:0033004)2.30477596
140phagosome maturation (GO:0090382)2.30062352
141embryonic process involved in female pregnancy (GO:0060136)2.29567409
142positive regulation of cellular amide metabolic process (GO:0034250)2.29472651
143positive regulation of muscle hypertrophy (GO:0014742)2.27582464
144positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27582464
145cellular response to vitamin D (GO:0071305)2.27317670
146intestinal epithelial cell development (GO:0060576)2.26936121
147regulation of chondrocyte differentiation (GO:0032330)2.26678135
148sprouting angiogenesis (GO:0002040)2.26178162
149regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.25674215
150ephrin receptor signaling pathway (GO:0048013)2.25338930
151* long-term synaptic potentiation (GO:0060291)2.25137820
152neuron projection extension (GO:1990138)2.25041149
153stress fiber assembly (GO:0043149)2.24584701
154positive regulation of chemokine biosynthetic process (GO:0045080)2.24079949
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.23998197
156cAMP catabolic process (GO:0006198)2.23835869
157regulation of cartilage development (GO:0061035)2.23634983
158regulation of postsynaptic membrane potential (GO:0060078)2.21731969
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20088642
160neuron-neuron synaptic transmission (GO:0007270)2.19815379
161layer formation in cerebral cortex (GO:0021819)2.18162375
162neurotransmitter-gated ion channel clustering (GO:0072578)2.17956522
163establishment of nucleus localization (GO:0040023)2.17225964
164exploration behavior (GO:0035640)2.16725356
165facial nerve structural organization (GO:0021612)2.16722221
166macrophage activation involved in immune response (GO:0002281)2.16293117
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.15823260
168membrane assembly (GO:0071709)2.15626440
169regulation of sarcomere organization (GO:0060297)2.15000316
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14851961
171postsynaptic membrane organization (GO:0001941)2.13917511
172wound healing, spreading of cells (GO:0044319)2.13793222
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.13273875
174negative chemotaxis (GO:0050919)2.13176743
175positive regulation of axon extension (GO:0045773)2.12378233
176transferrin transport (GO:0033572)2.12376850
177gamma-aminobutyric acid signaling pathway (GO:0007214)2.09418982
178regulation of synaptic vesicle transport (GO:1902803)2.09399580
179microglial cell activation (GO:0001774)2.09389182
180chondrocyte proliferation (GO:0035988)2.08022549
181response to histamine (GO:0034776)2.07779351
182plasma membrane repair (GO:0001778)2.07573356
183vesicle transport along microtubule (GO:0047496)2.07538167
184positive regulation of dendritic spine morphogenesis (GO:0061003)2.07412594
185positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.06725416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.85665242
2GBX2_23144817_ChIP-Seq_PC3_Human3.02690107
3EZH2_22144423_ChIP-Seq_EOC_Human2.90231036
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.80433385
5ZNF263_19887448_ChIP-Seq_K562_Human2.75535133
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66189516
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.59743358
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.58606101
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51048634
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36691249
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35651901
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35324124
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.34471345
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28996816
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17278108
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15261152
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10854726
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06774850
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06774850
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.06090892
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.00225328
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.94371611
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94129488
24CLOCK_20551151_ChIP-Seq_293T_Human1.92848453
25AR_21572438_ChIP-Seq_LNCaP_Human1.90627942
26* TP53_18474530_ChIP-ChIP_U2OS_Human1.87340989
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86459419
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85880356
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83961402
30* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83029449
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82689971
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82689971
33* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80746779
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76038189
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.75530068
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69908433
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68832566
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66855673
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.66567196
40TP53_16413492_ChIP-PET_HCT116_Human1.63305365
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62466264
42* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61725653
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.60772586
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53733679
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.52689434
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52383933
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49655166
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.48848310
49AR_21909140_ChIP-Seq_LNCAP_Human1.47061981
50P300_19829295_ChIP-Seq_ESCs_Human1.46406933
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46271457
52* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45801883
53* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45428169
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45159324
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43881072
56CJUN_26792858_Chip-Seq_BT549_Human1.43623487
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43529814
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.42185370
59SMAD4_21799915_ChIP-Seq_A2780_Human1.41995110
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41425357
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41216188
62* RARB_27405468_Chip-Seq_BRAIN_Mouse1.40796103
63RXR_22108803_ChIP-Seq_LS180_Human1.40355685
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39184782
65AHR_22903824_ChIP-Seq_MCF-7_Human1.37665457
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.36931666
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35078960
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34522458
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.34201492
70DROSHA_22980978_ChIP-Seq_HELA_Human1.33329227
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.33001720
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32838974
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30987242
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30876070
75* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30045435
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.29862568
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28381161
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28328911
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27149104
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.26351791
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26117245
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25862717
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25781539
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25181923
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25143004
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24983677
87* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24533758
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24523176
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24416051
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23996481
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23647536
92* AR_25329375_ChIP-Seq_VCAP_Human1.20706087
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20361995
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.19788000
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.19267486
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19140696
97REST_21632747_ChIP-Seq_MESCs_Mouse1.16567518
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15458572
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14570735
100VDR_24787735_ChIP-Seq_THP-1_Human1.13796072
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13625804
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13569896
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12489340
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.12050290
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11610199
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.11330442
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.11072969
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.09977569
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09720079
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09392544
111* ATF3_27146783_Chip-Seq_COLON_Human1.06582862
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05922969
113* JUN_21703547_ChIP-Seq_K562_Human1.05705632
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.05447984
115TAF15_26573619_Chip-Seq_HEK293_Human1.05352487
116* TP53_20018659_ChIP-ChIP_R1E_Mouse1.05057970
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04580578
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04446190
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04220487
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03495953
121* BRD4_25478319_ChIP-Seq_HGPS_Human1.03290520
122* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01866379
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00502784
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00381522
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.00131704
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99293287
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99293287
128* TP53_22127205_ChIP-Seq_IMR90_Human0.99241820
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98627038
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.98507643
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98110727
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97386341
133FUS_26573619_Chip-Seq_HEK293_Human0.97336444
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97132240
135* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96821753
136JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96802707
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96133813
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.95864947
139* TP63_23658742_ChIP-Seq_EP156T_Human0.95835026
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95619486
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95429890
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.95058594
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94438999
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93814005
145* SOX2_20726797_ChIP-Seq_SW620_Human0.93110710
146* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92459639
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.92427816
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.92132715
149ELK1_19687146_ChIP-ChIP_HELA_Human0.92027084
150FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91639202
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.91429458
152ER_23166858_ChIP-Seq_MCF-7_Human0.91358981
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91278283
154MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88735098
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88693760
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87423799
157EWS_26573619_Chip-Seq_HEK293_Human0.86794945
158TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84662821
159ELK1_22589737_ChIP-Seq_MCF10A_Human0.84213371
160TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83977226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.94639819
2MP0005083_abnormal_biliary_tract4.75909577
3MP0003880_abnormal_central_pattern3.41333170
4MP0000537_abnormal_urethra_morphology3.17344441
5MP0010368_abnormal_lymphatic_system2.86540439
6MP0005167_abnormal_blood-brain_barrier2.83361426
7MP0009780_abnormal_chondrocyte_physiolo2.71058821
8MP0001879_abnormal_lymphatic_vessel2.51946053
9MP0003635_abnormal_synaptic_transmissio2.50628590
10MP0003950_abnormal_plasma_membrane2.40984310
11MP0002063_abnormal_learning/memory/cond2.37698476
12MP0004272_abnormal_basement_membrane2.35637807
13MP0005623_abnormal_meninges_morphology2.34901781
14MP0003828_pulmonary_edema2.30425052
15MP0002736_abnormal_nociception_after2.28106538
16MP0005171_absent_coat_pigmentation2.22150576
17MP0009745_abnormal_behavioral_response2.15522674
18MP0003303_peritoneal_inflammation2.12311403
19MP0010030_abnormal_orbit_morphology2.11853665
20MP0003091_abnormal_cell_migration2.11008475
21MP0001968_abnormal_touch/_nociception2.04213950
22MP0004270_analgesia2.03239292
23MP0001501_abnormal_sleep_pattern1.99139766
24MP0010352_gastrointestinal_tract_polyps1.97742358
25MP0000569_abnormal_digit_pigmentation1.96464298
26MP0000003_abnormal_adipose_tissue1.94049033
27MP0003941_abnormal_skin_development1.89105713
28MP0003705_abnormal_hypodermis_morpholog1.82859526
29MP0003075_altered_response_to1.82811811
30MP0001188_hyperpigmentation1.82564480
31MP0008438_abnormal_cutaneous_collagen1.78333404
32MP0004510_myositis1.78070822
33MP0010678_abnormal_skin_adnexa1.70513697
34MP0002064_seizures1.69758394
35MP0004233_abnormal_muscle_weight1.68466094
36MP0004484_altered_response_of1.67163244
37MP0009053_abnormal_anal_canal1.66009891
38MP0002572_abnormal_emotion/affect_behav1.62140780
39MP0000762_abnormal_tongue_morphology1.61609843
40MP0005501_abnormal_skin_physiology1.61209171
41MP0004858_abnormal_nervous_system1.59485401
42MP0004883_abnormal_blood_vessel1.54958414
43MP0008004_abnormal_stomach_pH1.53526578
44MP0005164_abnormal_response_to1.52023643
45MP0002796_impaired_skin_barrier1.51312330
46MP0003279_aneurysm1.49391944
47MP0001440_abnormal_grooming_behavior1.49226964
48MP0005248_abnormal_Harderian_gland1.47265039
49MP0002735_abnormal_chemical_nociception1.46402735
50MP0000767_abnormal_smooth_muscle1.40681818
51MP0005409_darkened_coat_color1.39399980
52MP0002697_abnormal_eye_size1.39160331
53MP0009046_muscle_twitch1.38631056
54MP0002060_abnormal_skin_morphology1.38492303
55MP0003724_increased_susceptibility_to1.37455579
56MP0002877_abnormal_melanocyte_morpholog1.37121034
57MP0009278_abnormal_bone_marrow1.37026539
58MP0000534_abnormal_ureter_morphology1.36845658
59MP0002822_catalepsy1.35301922
60MP0002148_abnormal_hypersensitivity_rea1.33805718
61MP0005166_decreased_susceptibility_to1.32929378
62MP0000579_abnormal_nail_morphology1.32552113
63MP0002332_abnormal_exercise_endurance1.32172560
64MP0005220_abnormal_exocrine_pancreas1.29971266
65MP0005257_abnormal_intraocular_pressure1.26723216
66MP0003755_abnormal_palate_morphology1.26704737
67MP0000383_abnormal_hair_follicle1.26464781
68MP0005197_abnormal_uvea_morphology1.24690537
69MP0003566_abnormal_cell_adhesion1.21582797
70MP0010386_abnormal_urinary_bladder1.18863659
71MP0005595_abnormal_vascular_smooth1.18663824
72MP0000778_abnormal_nervous_system1.18480810
73MP0002998_abnormal_bone_remodeling1.16540894
74MP0005085_abnormal_gallbladder_physiolo1.16303799
75MP0001533_abnormal_skeleton_physiology1.15933090
76MP0005503_abnormal_tendon_morphology1.14807805
77MP0003045_fibrosis1.14768778
78MP0002734_abnormal_mechanical_nocicepti1.14407041
79MP0006054_spinal_hemorrhage1.11538494
80MP0010234_abnormal_vibrissa_follicle1.11499280
81MP0003436_decreased_susceptibility_to1.11243381
82MP0003937_abnormal_limbs/digits/tail_de1.11032570
83MP0002295_abnormal_pulmonary_circulatio1.11017448
84MP0003935_abnormal_craniofacial_develop1.09952208
85MP0004811_abnormal_neuron_physiology1.09533156
86MP0000467_abnormal_esophagus_morphology1.09207696
87MP0000427_abnormal_hair_cycle1.06344459
88MP0001958_emphysema1.04334696
89MP0000343_altered_response_to1.02814537
90MP0005084_abnormal_gallbladder_morpholo1.02408169
91MP0003448_altered_tumor_morphology1.02256818
92MP0003787_abnormal_imprinting1.02238961
93MP0000647_abnormal_sebaceous_gland1.01935286
94MP0005165_increased_susceptibility_to1.00791277
95MP0005187_abnormal_penis_morphology0.99236392
96MP0000462_abnormal_digestive_system0.98212897
97MP0010771_integument_phenotype0.98123457
98MP0003122_maternal_imprinting0.98072068
99MP0002098_abnormal_vibrissa_morphology0.94217629
100MP0002419_abnormal_innate_immunity0.93869849
101MP0002009_preneoplasia0.92457491
102MP0002084_abnormal_developmental_patter0.91631343
103MP0000516_abnormal_urinary_system0.90744040
104MP0005367_renal/urinary_system_phenotyp0.90744040
105MP0009250_abnormal_appendicular_skeleto0.90429257
106MP0001849_ear_inflammation0.89515162
107MP0005390_skeleton_phenotype0.88107905
108MP0002896_abnormal_bone_mineralization0.87867955
109MP0001486_abnormal_startle_reflex0.87254419
110MP0002733_abnormal_thermal_nociception0.86507571
111MP0005275_abnormal_skin_tensile0.85901715
112MP0001542_abnormal_bone_strength0.85865496
113MP0002233_abnormal_nose_morphology0.85407149
114MP0001177_atelectasis0.85194177
115MP0003385_abnormal_body_wall0.84688457
116MP0002184_abnormal_innervation0.84340085
117MP0000751_myopathy0.83619853
118MP0002133_abnormal_respiratory_system0.83048390
119MP0005388_respiratory_system_phenotype0.83048390
120MP0001348_abnormal_lacrimal_gland0.82513074
121MP0003943_abnormal_hepatobiliary_system0.82132904
122MP0001286_abnormal_eye_development0.81884290
123MP0009384_cardiac_valve_regurgitation0.81344520
124MP0000750_abnormal_muscle_regeneration0.80631067
125MP0009785_altered_susceptibility_to0.80334743
126MP0000249_abnormal_blood_vessel0.80167453
127MP0001299_abnormal_eye_distance/0.79440069
128MP0006138_congestive_heart_failure0.79388596
129MP0003942_abnormal_urinary_system0.79219162
130MP0001970_abnormal_pain_threshold0.78667768
131MP0000538_abnormal_urinary_bladder0.78526366
132MP0004264_abnormal_extraembryonic_tissu0.78267044
133* MP0002086_abnormal_extraembryonic_tissu0.77924120
134MP0009703_decreased_birth_body0.77856847
135MP0002177_abnormal_outer_ear0.76753306
136MP0003633_abnormal_nervous_system0.76195705
137MP0002282_abnormal_trachea_morphology0.75951249
138MP0002925_abnormal_cardiovascular_devel0.74791546
139MP0004133_heterotaxia0.73975649
140MP0002272_abnormal_nervous_system0.73243785
141MP0001216_abnormal_epidermal_layer0.72814297
142* MP0003984_embryonic_growth_retardation0.72210666
143* MP0002088_abnormal_embryonic_growth/wei0.71599942
144MP0000013_abnormal_adipose_tissue0.71538819
145MP0005076_abnormal_cell_differentiation0.71380119
146MP0000377_abnormal_hair_follicle0.71085291
147MP0001243_abnormal_dermal_layer0.70972141
148MP0005386_behavior/neurological_phenoty0.70740253
149MP0004924_abnormal_behavior0.70740253
150MP0005508_abnormal_skeleton_morphology0.70265313
151MP0000428_abnormal_craniofacial_morphol0.70195130
152MP0002067_abnormal_sensory_capabilities0.69754050
153MP0000613_abnormal_salivary_gland0.69653245
154MP0002111_abnormal_tail_morphology0.69549958
155MP0000627_abnormal_mammary_gland0.68961910
156MP0000733_abnormal_muscle_development0.68822012
157MP0000432_abnormal_head_morphology0.68522577
158MP0002092_abnormal_eye_morphology0.68004057
159MP0005023_abnormal_wound_healing0.67569859
160MP0001851_eye_inflammation0.67028809
161MP0005193_abnormal_anterior_eye0.66987773
162MP0009764_decreased_sensitivity_to0.66731906
163MP0003329_amyloid_beta_deposits0.65830046
164MP0004782_abnormal_surfactant_physiolog0.65085553
165* MP0005380_embryogenesis_phenotype0.65084160
166* MP0001672_abnormal_embryogenesis/_devel0.65084160
167MP0001614_abnormal_blood_vessel0.65065064
168MP0002128_abnormal_blood_circulation0.64667879
169MP0008874_decreased_physiological_sensi0.64652948
170MP0004085_abnormal_heartbeat0.64093814
171MP0002090_abnormal_vision0.63524428

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.30798008
2Entropion (HP:0000621)3.27407699
3Focal seizures (HP:0007359)3.18117101
4Cardiovascular calcification (HP:0011915)3.10482813
5Distal lower limb amyotrophy (HP:0008944)2.94529500
6Absent frontal sinuses (HP:0002688)2.91931602
7Vascular calcification (HP:0004934)2.88581615
8Lower limb amyotrophy (HP:0007210)2.88126150
9Epileptic encephalopathy (HP:0200134)2.81645223
10Atonic seizures (HP:0010819)2.80915408
11Epiphyseal dysplasia (HP:0002656)2.77119262
12Popliteal pterygium (HP:0009756)2.76322330
13Short nail (HP:0001799)2.73571484
14Myokymia (HP:0002411)2.73013729
15Reduced subcutaneous adipose tissue (HP:0003758)2.72610520
16Vascular tortuosity (HP:0004948)2.62688086
17Arterial tortuosity (HP:0005116)2.54413917
18Right ventricular cardiomyopathy (HP:0011663)2.53136323
19Premature rupture of membranes (HP:0001788)2.47582103
20Asymmetry of the thorax (HP:0001555)2.46472141
21Protrusio acetabuli (HP:0003179)2.41533772
22Heterochromia iridis (HP:0001100)2.40584097
23Mitral stenosis (HP:0001718)2.40385930
24Febrile seizures (HP:0002373)2.40154588
25Shallow orbits (HP:0000586)2.39087181
26Fair hair (HP:0002286)2.31123341
27Amblyopia (HP:0000646)2.29217493
28Absence seizures (HP:0002121)2.25863207
29Poikiloderma (HP:0001029)2.22339218
30Hydroureter (HP:0000072)2.22329962
31Spinal rigidity (HP:0003306)2.21411706
32Abnormality of the nasal septum (HP:0000419)2.19884112
33Conjugated hyperbilirubinemia (HP:0002908)2.17969406
34Pterygium (HP:0001059)2.13586125
35Elbow flexion contracture (HP:0002987)2.12977349
36Atrophic scars (HP:0001075)2.08840099
37Dilatation of the ascending aorta (HP:0005111)2.08785421
38Dialeptic seizures (HP:0011146)2.08193844
39Abnormality of the frontal sinuses (HP:0002687)2.06891722
40Subacute progressive viral hepatitis (HP:0006572)2.06472135
41Eczematoid dermatitis (HP:0000976)2.05534328
42Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04981841
43Cerebellar dysplasia (HP:0007033)2.04222374
44Aplasia cutis congenita (HP:0001057)2.03637607
45Thick nail (HP:0001805)2.02597757
46Micronodular cirrhosis (HP:0001413)2.02343700
47Recurrent gram-negative bacterial infections (HP:0005420)2.02123203
48Neonatal short-limb short stature (HP:0008921)2.01646620
49Enlarged penis (HP:0000040)2.00892809
50Depressed nasal tip (HP:0000437)2.00634300
51Distal lower limb muscle weakness (HP:0009053)2.00319478
52Bradycardia (HP:0001662)1.99204129
53Knee flexion contracture (HP:0006380)1.98563129
54Cutaneous melanoma (HP:0012056)1.98522983
55Wormian bones (HP:0002645)1.98383059
56Cerebral aneurysm (HP:0004944)1.98291362
57Vertebral compression fractures (HP:0002953)1.97333770
58Choroideremia (HP:0001139)1.97074761
59Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95959369
60Advanced eruption of teeth (HP:0006288)1.94831616
61Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.94130727
62Abnormality of the 2nd finger (HP:0004100)1.93258391
63Protruding tongue (HP:0010808)1.89610547
64Pulmonic stenosis (HP:0001642)1.89104655
65Hyperventilation (HP:0002883)1.88365908
66Hypokinesia (HP:0002375)1.87614632
67Lip pit (HP:0100267)1.87304915
68Mediastinal lymphadenopathy (HP:0100721)1.87122332
69Osteolytic defects of the hand bones (HP:0009699)1.87074206
70Osteolytic defects of the phalanges of the hand (HP:0009771)1.87074206
71Growth hormone excess (HP:0000845)1.86691693
72Soft skin (HP:0000977)1.86284216
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86260238
74Porencephaly (HP:0002132)1.84662015
75Recurrent abscess formation (HP:0002722)1.84471354
76Generalized tonic-clonic seizures (HP:0002069)1.84269517
77Diplopia (HP:0000651)1.83216353
78Abnormality of binocular vision (HP:0011514)1.83216353
79Mutism (HP:0002300)1.81961325
80Hematochezia (HP:0002573)1.80080366
81Submucous cleft hard palate (HP:0000176)1.79849682
82Increased connective tissue (HP:0009025)1.79707912
83Progressive sensorineural hearing impairment (HP:0000408)1.79312504
84Increased cerebral lipofuscin (HP:0011813)1.78850742
85Aortic aneurysm (HP:0004942)1.78814105
86Sparse lateral eyebrow (HP:0005338)1.77601056
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77077212
88Limb-girdle muscle atrophy (HP:0003797)1.76477069
89Cupped ribs (HP:0000887)1.76110073
90Elfin facies (HP:0004428)1.75847708
91Relative macrocephaly (HP:0004482)1.74743880
92Ulnar bowing (HP:0003031)1.74400164
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74322800
94Visual hallucinations (HP:0002367)1.74022270
95Abnormality of the hip-girdle musculature (HP:0001445)1.73972481
96Abnormality of the musculature of the pelvis (HP:0001469)1.73972481
97Broad-based gait (HP:0002136)1.73339503
98Cervical subluxation (HP:0003308)1.72711347
99Spinal cord compression (HP:0002176)1.72686005
100Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72577753
101Alopecia of scalp (HP:0002293)1.72290271
102Hypoplasia of the iris (HP:0007676)1.71671866
103Microglossia (HP:0000171)1.71019094
104Abnormality of the distal phalanges of the toes (HP:0010182)1.70747972
105Wrist flexion contracture (HP:0001239)1.70562787
106Fragile skin (HP:0001030)1.70322581
107Progressive cerebellar ataxia (HP:0002073)1.70285415
108Aortic dissection (HP:0002647)1.69978116
109Upper limb amyotrophy (HP:0009129)1.69367427
110Distal upper limb amyotrophy (HP:0007149)1.69367427
111Syringomyelia (HP:0003396)1.68902887
112Spinal cord lesions (HP:0100561)1.68902887
113Overgrowth (HP:0001548)1.68857838
114Fused cervical vertebrae (HP:0002949)1.68635551
115Apathy (HP:0000741)1.67272039
116Xerostomia (HP:0000217)1.67269210
117Inappropriate behavior (HP:0000719)1.66998980
118Metaphyseal dysplasia (HP:0100255)1.66938946
119Abnormality of salivation (HP:0100755)1.66775237
120Palpebral edema (HP:0100540)1.66562601
121Drooling (HP:0002307)1.66528250
122Excessive salivation (HP:0003781)1.66528250
123Mild short stature (HP:0003502)1.66304419
124Hypoplastic ischia (HP:0003175)1.66144609
125Difficulty climbing stairs (HP:0003551)1.66110079
126Long foot (HP:0001833)1.66036313
127Ulnar claw (HP:0001178)1.65736582
128Genu recurvatum (HP:0002816)1.65612096
129Broad nasal tip (HP:0000455)1.65478995
130Follicular hyperkeratosis (HP:0007502)1.65238629
131Generalized hypopigmentation of hair (HP:0011358)1.65003909
132Vitreoretinal degeneration (HP:0000655)1.64499281
133Optic neuritis (HP:0100653)1.63907101
134Retrobulbar optic neuritis (HP:0100654)1.63907101
135Orchitis (HP:0100796)1.62929050
136Vertebral clefting (HP:0008428)1.60854942
137Deviation of the thumb (HP:0009603)1.60439430
138Bronchomalacia (HP:0002780)1.60373995
139Short chin (HP:0000331)1.59415376
140Abnormality of glutamine family amino acid metabolism (HP:0010902)1.58782409
141Lower limb asymmetry (HP:0100559)1.58561720
142Congenital glaucoma (HP:0001087)1.57697633
143Short metatarsal (HP:0010743)1.57620843
144Neoplasm of the adrenal cortex (HP:0100641)1.57583022
145Onycholysis (HP:0001806)1.57230213
146Natal tooth (HP:0000695)1.57116216
147Hypoglycemic seizures (HP:0002173)1.56291839
148Diminished movement (HP:0002374)1.54613065
149Mitral valve prolapse (HP:0001634)1.54448142
150Unilateral renal agenesis (HP:0000122)1.54336444
151Open mouth (HP:0000194)1.53992948
152Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.53314362
153Buphthalmos (HP:0000557)1.53161669
154Abnormality of the epiphyses of the hand (HP:0005924)1.52880625
155Curly hair (HP:0002212)1.52875718
156Long toe (HP:0010511)1.52517782
157Supranuclear gaze palsy (HP:0000605)1.52466436
158Bicuspid aortic valve (HP:0001647)1.51058382
159J-shaped sella turcica (HP:0002680)1.50987964
160Prominent supraorbital ridges (HP:0000336)1.50982393
161Ankle contracture (HP:0006466)1.50617592
162Pelvic girdle muscle weakness (HP:0003749)1.50006748
163Tetraparesis (HP:0002273)1.49881455
164Incomplete penetrance (HP:0003829)1.49565503
165Hypoventilation (HP:0002791)1.49496957
166Glossoptosis (HP:0000162)1.49368289
167Glucose intolerance (HP:0000833)1.49286250
168Abnormality of macrophages (HP:0004311)1.47995595
169Insulin-resistant diabetes mellitus (HP:0000831)1.47825915
170Esophageal varix (HP:0002040)1.46892927
171Shoulder girdle muscle weakness (HP:0003547)1.46666064
172Abnormality of dentin (HP:0010299)1.46096772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.82418014
2RIPK44.08505801
3TIE13.95806929
4NTRK33.09190441
5INSRR3.04541338
6PLK22.87184394
7MET2.69094873
8STK392.55878347
9BRSK22.41999251
10PTK2B2.37331115
11SIK32.28190783
12LATS12.28139335
13MAP3K142.12559217
14DAPK22.07085669
15ERBB32.03157589
16CASK2.02540380
17BMPR21.87142926
18KSR11.79933391
19KDR1.75937472
20DDR21.66536208
21MAP3K91.61869843
22PAK41.60756383
23NEK61.60514249
24BMX1.57771848
25BRD41.54722024
26MINK11.54030645
27MAP3K121.53570015
28SIK21.51966322
29FER1.49760816
30KSR21.49009459
31TYRO31.47787726
32MYLK1.47711143
33WNK41.44269409
34MAP3K41.44102112
35AKT31.42753930
36MARK11.36334038
37LIMK11.34837853
38WEE11.33393910
39NTRK21.31507104
40MAP2K71.28411937
41BRSK11.25246211
42TESK11.22925306
43OXSR11.21452753
44PDGFRA1.21389822
45SCYL21.21165460
46SIK11.21020431
47EPHA21.19860327
48DMPK1.18823883
49FGR1.16988883
50LATS21.16524366
51TBK11.14753729
52DAPK11.14056417
53PAK61.13194338
54CDK81.10854292
55FGFR21.08478681
56GRK71.03175837
57TGFBR21.02669108
58EPHB21.00326342
59EIF2AK30.97502445
60MAP2K10.96881254
61TTN0.96611379
62TRIM280.93587180
63PBK0.91937368
64STK38L0.91547498
65PRKCE0.91238759
66LMTK20.90603931
67CDK50.90447142
68MOS0.89217410
69RIPK10.88950362
70RAF10.88231689
71MAPK70.88199234
72PDK20.87915165
73CAMK2A0.87367444
74TRPM70.78142072
75GRK50.77463711
76FES0.77024170
77PAK20.75129568
78PRPF4B0.75065461
79CAMK2B0.74679677
80TAOK20.74291573
81FRK0.73594791
82PDGFRB0.73161559
83CAMKK10.72304691
84ARAF0.71461545
85FGFR30.71347598
86DAPK30.67134639
87BCR0.66746736
88MELK0.66460141
89MST40.65356016
90FLT30.65204717
91MTOR0.63586611
92MAP2K40.63335296
93PTK20.63254530
94RET0.62941242
95PRKCG0.62310504
96EIF2AK10.62148301
97MAP3K30.61465417
98MAP3K20.60597944
99STK30.60051336
100NTRK10.60015543
101PIM20.59972866
102RPS6KB20.58620065
103MAP3K130.58546809
104ROCK10.58272807
105ERBB40.58239267
106TGFBR10.57476364
107PAK30.57090952
108CSNK1G10.55280764
109SGK10.54318312
110CSNK1A1L0.53668407
111PIK3CA0.53424153
112HCK0.50691399
113EGFR0.50324015
114ABL20.50061785
115MAP3K10.49856293
116MAPK120.49640611
117ROCK20.49457321
118MARK30.49431610
119ICK0.48248583
120BMPR1B0.45571222
121MAPKAPK30.45358155
122EPHB10.45032081
123ILK0.44817478
124IKBKB0.44074153
125GSK3A0.43530161
126YES10.42466617
127INSR0.41105300
128SGK20.40964298
129STK380.40797773
130DYRK1A0.40264043
131CHUK0.39479198
132CDK140.38317250
133CAMK2D0.37772116
134CDK180.37669625
135SRC0.37532832
136EPHA30.37326966
137PRKD30.36826974
138CSNK1G30.36703112
139TSSK60.36353106
140CDK60.35894671
141SGK30.35009261
142MST1R0.34957482
143ADRBK10.33556448
144CAMK2G0.32948612
145FGFR10.32890070
146MUSK0.32099752
147FYN0.31859814
148PRKCI0.31641100
149SRPK10.31617427
150PTK60.31328709
151EIF2AK20.30611406
152MKNK20.29828677
153AKT20.29348357
154NEK90.28250569
155RPS6KA20.25758685
156AURKB0.24687264
157PKN20.23182767

Predicted pathways (KEGG)

RankGene SetZ-score
1TGF-beta signaling pathway_Homo sapiens_hsa043502.65910762
2Hippo signaling pathway_Homo sapiens_hsa043902.29521175
3Nicotine addiction_Homo sapiens_hsa050332.02724365
4Synaptic vesicle cycle_Homo sapiens_hsa047211.87541735
5p53 signaling pathway_Homo sapiens_hsa041151.84143541
6Rheumatoid arthritis_Homo sapiens_hsa053231.82437277
7Long-term potentiation_Homo sapiens_hsa047201.78382796
8Small cell lung cancer_Homo sapiens_hsa052221.71574256
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70593514
10Circadian entrainment_Homo sapiens_hsa047131.61443294
11Tight junction_Homo sapiens_hsa045301.56953787
12Selenocompound metabolism_Homo sapiens_hsa004501.54805890
13Amphetamine addiction_Homo sapiens_hsa050311.50777762
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49648615
15Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.49572837
16Collecting duct acid secretion_Homo sapiens_hsa049661.48768489
17Arginine biosynthesis_Homo sapiens_hsa002201.46672471
18African trypanosomiasis_Homo sapiens_hsa051431.42388100
19Olfactory transduction_Homo sapiens_hsa047401.40342470
20Morphine addiction_Homo sapiens_hsa050321.38371457
21Salmonella infection_Homo sapiens_hsa051321.35233838
22Glutamatergic synapse_Homo sapiens_hsa047241.34806163
23TNF signaling pathway_Homo sapiens_hsa046681.31655929
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31497186
25Leishmaniasis_Homo sapiens_hsa051401.29632378
26MicroRNAs in cancer_Homo sapiens_hsa052061.29556219
27Vibrio cholerae infection_Homo sapiens_hsa051101.29385106
28Salivary secretion_Homo sapiens_hsa049701.29144564
29Phagosome_Homo sapiens_hsa041451.28060425
30Bladder cancer_Homo sapiens_hsa052191.26161484
31Oxytocin signaling pathway_Homo sapiens_hsa049211.25733776
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25195554
33Sphingolipid metabolism_Homo sapiens_hsa006001.24689603
34Long-term depression_Homo sapiens_hsa047301.24574391
35Tuberculosis_Homo sapiens_hsa051521.21581621
36GABAergic synapse_Homo sapiens_hsa047271.20109805
37Dopaminergic synapse_Homo sapiens_hsa047281.19940560
38Axon guidance_Homo sapiens_hsa043601.17751420
39Cholinergic synapse_Homo sapiens_hsa047251.16286797
40Glioma_Homo sapiens_hsa052141.16285938
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15519037
42GnRH signaling pathway_Homo sapiens_hsa049121.15441037
43Malaria_Homo sapiens_hsa051441.14586677
44N-Glycan biosynthesis_Homo sapiens_hsa005101.12845351
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12195468
46Serotonergic synapse_Homo sapiens_hsa047261.11960122
47Basal cell carcinoma_Homo sapiens_hsa052171.11578252
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11373500
49Osteoclast differentiation_Homo sapiens_hsa043801.11291071
50Renin secretion_Homo sapiens_hsa049241.10036484
51Type I diabetes mellitus_Homo sapiens_hsa049401.09654806
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09151646
53Focal adhesion_Homo sapiens_hsa045101.08137716
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07879912
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07579615
56Adherens junction_Homo sapiens_hsa045201.07262843
57Hedgehog signaling pathway_Homo sapiens_hsa043401.06782501
58Gap junction_Homo sapiens_hsa045401.06730066
59Circadian rhythm_Homo sapiens_hsa047101.06114086
60Shigellosis_Homo sapiens_hsa051311.05877847
61Rap1 signaling pathway_Homo sapiens_hsa040151.05866109
62Calcium signaling pathway_Homo sapiens_hsa040201.04029742
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03715898
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02906902
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02827542
66Pertussis_Homo sapiens_hsa051331.02273708
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01868353
68VEGF signaling pathway_Homo sapiens_hsa043701.01775846
69Graft-versus-host disease_Homo sapiens_hsa053321.00414449
70ErbB signaling pathway_Homo sapiens_hsa040120.99645429
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99509568
72Amoebiasis_Homo sapiens_hsa051460.99337862
73Gastric acid secretion_Homo sapiens_hsa049710.98799604
74Cocaine addiction_Homo sapiens_hsa050300.98691027
75Dilated cardiomyopathy_Homo sapiens_hsa054140.97724786
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97380081
77ECM-receptor interaction_Homo sapiens_hsa045120.97019836
78Thyroid cancer_Homo sapiens_hsa052160.96813752
79Estrogen signaling pathway_Homo sapiens_hsa049150.95205297
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95199387
81Proteoglycans in cancer_Homo sapiens_hsa052050.93960877
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91664529
83Dorso-ventral axis formation_Homo sapiens_hsa043200.89802011
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89150649
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88055466
86Legionellosis_Homo sapiens_hsa051340.87852560
87Taste transduction_Homo sapiens_hsa047420.87503346
88Melanogenesis_Homo sapiens_hsa049160.87006207
89cAMP signaling pathway_Homo sapiens_hsa040240.86202578
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.85979082
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83943593
92MAPK signaling pathway_Homo sapiens_hsa040100.83438790
93Sulfur metabolism_Homo sapiens_hsa009200.83428062
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.83339056
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83289916
96Insulin secretion_Homo sapiens_hsa049110.83155723
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.82597234
98Ras signaling pathway_Homo sapiens_hsa040140.80023922
99Pathways in cancer_Homo sapiens_hsa052000.79910789
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78564857
101Chemokine signaling pathway_Homo sapiens_hsa040620.77798149
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77467715
103Sulfur relay system_Homo sapiens_hsa041220.76767164
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.76015873
105Nitrogen metabolism_Homo sapiens_hsa009100.75983569
106Chronic myeloid leukemia_Homo sapiens_hsa052200.75833627
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75650231
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.75559478
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75413855
110Choline metabolism in cancer_Homo sapiens_hsa052310.75240519
111Pancreatic secretion_Homo sapiens_hsa049720.74686778
112Platelet activation_Homo sapiens_hsa046110.74538926
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74438780
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74434627
115HIF-1 signaling pathway_Homo sapiens_hsa040660.74250420
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74019292
117Folate biosynthesis_Homo sapiens_hsa007900.73452714
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73226383
119Glucagon signaling pathway_Homo sapiens_hsa049220.73163356
120Toxoplasmosis_Homo sapiens_hsa051450.73020283
121Renal cell carcinoma_Homo sapiens_hsa052110.72996036
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.71689005
123Endometrial cancer_Homo sapiens_hsa052130.71200406
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71172649
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69883037
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68691937
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68092379
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.67166972
129Influenza A_Homo sapiens_hsa051640.67112396
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67067975
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66664840
132* FoxO signaling pathway_Homo sapiens_hsa040680.66639147
133Type II diabetes mellitus_Homo sapiens_hsa049300.66521002
134mTOR signaling pathway_Homo sapiens_hsa041500.64772398
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.64540689
136Prion diseases_Homo sapiens_hsa050200.64235118
137Hepatitis B_Homo sapiens_hsa051610.64159023
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63606714
139AMPK signaling pathway_Homo sapiens_hsa041520.63552114
140Melanoma_Homo sapiens_hsa052180.62694835
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62174415
142Protein digestion and absorption_Homo sapiens_hsa049740.62005933
143Wnt signaling pathway_Homo sapiens_hsa043100.60986576
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60538917
145Viral myocarditis_Homo sapiens_hsa054160.60256270
146Inositol phosphate metabolism_Homo sapiens_hsa005620.59394758
147Biosynthesis of amino acids_Homo sapiens_hsa012300.56382776
148Prostate cancer_Homo sapiens_hsa052150.56167771
149Cell cycle_Homo sapiens_hsa041100.54953588
150Endocytosis_Homo sapiens_hsa041440.54670097
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.51006147
152mRNA surveillance pathway_Homo sapiens_hsa030150.50987727
153RNA transport_Homo sapiens_hsa030130.46931716
154Pancreatic cancer_Homo sapiens_hsa052120.46451385
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43851976
156Basal transcription factors_Homo sapiens_hsa030220.42513131
157Insulin resistance_Homo sapiens_hsa049310.41147583
158Insulin signaling pathway_Homo sapiens_hsa049100.40883964
159Ovarian steroidogenesis_Homo sapiens_hsa049130.40699779
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39745297
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38839859

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