PLK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.85333809
2mitotic metaphase plate congression (GO:0007080)5.53310208
3protein localization to chromosome, centromeric region (GO:0071459)5.22790011
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.10519769
5* mitotic sister chromatid segregation (GO:0000070)4.96793258
6regulation of spindle organization (GO:0090224)4.91604362
7DNA unwinding involved in DNA replication (GO:0006268)4.79491667
8metaphase plate congression (GO:0051310)4.79389559
9DNA topological change (GO:0006265)4.63141446
10mitotic chromosome condensation (GO:0007076)4.59855256
11* sister chromatid segregation (GO:0000819)4.51524274
12* mitotic nuclear envelope disassembly (GO:0007077)4.51007520
13establishment of chromosome localization (GO:0051303)4.42145696
14DNA ligation (GO:0006266)4.37957753
15kinetochore organization (GO:0051383)4.37633791
16DNA strand elongation involved in DNA replication (GO:0006271)4.33652843
17attachment of spindle microtubules to kinetochore (GO:0008608)4.30167812
18DNA replication initiation (GO:0006270)4.26823371
19regulation of mitotic spindle organization (GO:0060236)4.23986263
20* nuclear envelope disassembly (GO:0051081)4.17345931
21* membrane disassembly (GO:0030397)4.17345931
22DNA strand elongation (GO:0022616)4.11364847
23CENP-A containing nucleosome assembly (GO:0034080)4.04176453
24nuclear pore organization (GO:0006999)4.03953480
25kinetochore assembly (GO:0051382)4.02018381
26chromatin remodeling at centromere (GO:0031055)3.97867942
27DNA replication checkpoint (GO:0000076)3.94776247
28DNA replication-dependent nucleosome organization (GO:0034723)3.90187108
29DNA replication-dependent nucleosome assembly (GO:0006335)3.90187108
30telomere maintenance via semi-conservative replication (GO:0032201)3.87215339
31* regulation of chromosome segregation (GO:0051983)3.85206867
32formation of translation preinitiation complex (GO:0001731)3.81664133
33DNA replication-independent nucleosome organization (GO:0034724)3.75767533
34DNA replication-independent nucleosome assembly (GO:0006336)3.75767533
35nucleobase biosynthetic process (GO:0046112)3.75185803
36folic acid-containing compound biosynthetic process (GO:0009396)3.72827446
37nuclear pore complex assembly (GO:0051292)3.72155337
38* spindle checkpoint (GO:0031577)3.70221217
39mitotic sister chromatid cohesion (GO:0007064)3.64365968
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62084326
41* negative regulation of chromosome segregation (GO:0051985)3.61441558
42regulation of centrosome cycle (GO:0046605)3.52446557
43* negative regulation of mitotic sister chromatid separation (GO:2000816)3.52000741
44* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52000741
45* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52000741
46* negative regulation of sister chromatid segregation (GO:0033046)3.52000741
47histone exchange (GO:0043486)3.50965932
48* protein localization to chromosome (GO:0034502)3.48591661
49* positive regulation of chromosome segregation (GO:0051984)3.47892083
50telomere maintenance via recombination (GO:0000722)3.47863683
51mitotic recombination (GO:0006312)3.47658008
52* spindle assembly checkpoint (GO:0071173)3.47376602
53maturation of SSU-rRNA (GO:0030490)3.46866856
54meiotic chromosome segregation (GO:0045132)3.46299247
55* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45543157
56IMP biosynthetic process (GO:0006188)3.44716547
57* mitotic spindle assembly checkpoint (GO:0007094)3.43688906
58* mitotic spindle checkpoint (GO:0071174)3.43149027
59regulation of translational fidelity (GO:0006450)3.43018226
60* chromosome segregation (GO:0007059)3.42713871
61* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.42055781
62ribosome assembly (GO:0042255)3.39207848
63purine nucleobase biosynthetic process (GO:0009113)3.38343447
64* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.37331239
65establishment of viral latency (GO:0019043)3.36432813
66* nuclear envelope organization (GO:0006998)3.30437013
67chromosome condensation (GO:0030261)3.30049718
68* regulation of mitotic sister chromatid separation (GO:0010965)3.27451840
69* regulation of mitotic sister chromatid segregation (GO:0033047)3.27451840
70* regulation of sister chromatid segregation (GO:0033045)3.27451840
71DNA duplex unwinding (GO:0032508)3.26674879
72telomere maintenance via telomere lengthening (GO:0010833)3.26446063
73DNA geometric change (GO:0032392)3.25616852
74regulation of sister chromatid cohesion (GO:0007063)3.24644713
75microtubule depolymerization (GO:0007019)3.24039695
76ribosome biogenesis (GO:0042254)3.23799906
77chromatin assembly or disassembly (GO:0006333)3.22567370
78ventricular cardiac muscle cell development (GO:0055015)3.21231461
79histone-serine phosphorylation (GO:0035404)3.16939942
80regulation of exit from mitosis (GO:0007096)3.16099957
81negative regulation of mRNA processing (GO:0050686)3.15940610
82spliceosomal snRNP assembly (GO:0000387)3.11472516
83peptidyl-arginine omega-N-methylation (GO:0035247)3.09345506
84regulation of telomere maintenance via telomerase (GO:0032210)3.07610517
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.06612104
86* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06030260
87IMP metabolic process (GO:0046040)3.06011810
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05864781
89* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05046537
90ATP-dependent chromatin remodeling (GO:0043044)3.04742978
91L-serine metabolic process (GO:0006563)3.01701151
92* mitotic cell cycle (GO:0000278)3.00124347
93DNA conformation change (GO:0071103)2.99010118
94ribonucleoprotein complex biogenesis (GO:0022613)2.97833979
95* negative regulation of mitosis (GO:0045839)2.97639048
96heterochromatin organization (GO:0070828)2.96233706
97spindle assembly involved in mitosis (GO:0090307)2.96125427
98establishment of integrated proviral latency (GO:0075713)2.95964908
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94385510
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93986132
101cellular protein complex localization (GO:0034629)2.91658118
102ribosomal large subunit biogenesis (GO:0042273)2.91534173
103DNA packaging (GO:0006323)2.90969929
104ribosomal small subunit assembly (GO:0000028)2.90957090
105negative regulation of mRNA metabolic process (GO:1903312)2.90397652
106viral mRNA export from host cell nucleus (GO:0046784)2.90357109
107spindle organization (GO:0007051)2.90273523
108protein complex localization (GO:0031503)2.90221590
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89138770
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.89138770
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87915564
112negative regulation of ligase activity (GO:0051352)2.87915564
113translational initiation (GO:0006413)2.87144249
114protein K6-linked ubiquitination (GO:0085020)2.86433864
115pore complex assembly (GO:0046931)2.85427322
116negative regulation of RNA splicing (GO:0033119)2.85300179
117histone arginine methylation (GO:0034969)2.84507024
118spliceosomal complex assembly (GO:0000245)2.83859573
119rRNA processing (GO:0006364)2.83174753
120regulation of histone H3-K9 methylation (GO:0051570)2.82004375
121RNA splicing, via transesterification reactions (GO:0000375)2.81918609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26102368
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.35719437
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.01315064
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99949334
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.97104982
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68068911
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95833266
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88414339
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74238900
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69673431
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65123143
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.60168126
13AR_21909140_ChIP-Seq_LNCAP_Human2.52509266
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.48368086
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37261967
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31552398
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30684973
18* XRN2_22483619_ChIP-Seq_HELA_Human2.30009699
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.18106296
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15687705
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03425963
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02671087
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.02486908
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.01501309
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91797202
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88397038
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85577293
28VDR_23849224_ChIP-Seq_CD4+_Human1.84882247
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83520045
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80686508
31MYC_22102868_ChIP-Seq_BL_Human1.80029978
32DCP1A_22483619_ChIP-Seq_HELA_Human1.75874762
33CIITA_25753668_ChIP-Seq_RAJI_Human1.71819777
34TTF2_22483619_ChIP-Seq_HELA_Human1.70358131
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.69836597
36* GABP_19822575_ChIP-Seq_HepG2_Human1.69338468
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68926571
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67148577
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51016115
40KDM5A_27292631_Chip-Seq_BREAST_Human1.49665173
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48681052
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48192725
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47189849
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45599282
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45148445
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45010657
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44079779
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39048690
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.36554575
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33174429
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32406571
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.32380405
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31339337
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30515412
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28205703
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24223265
57ELK1_19687146_ChIP-ChIP_HELA_Human1.23890820
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23205936
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21569550
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20828886
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20370826
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18999330
63ZNF263_19887448_ChIP-Seq_K562_Human1.17306428
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17109945
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16466448
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16321936
67VDR_21846776_ChIP-Seq_THP-1_Human1.14911367
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10937513
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10289974
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10009185
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09693149
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09419069
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08596283
74TFEB_21752829_ChIP-Seq_HELA_Human1.07536925
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.05850320
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05000593
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02062497
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01794070
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99944712
80TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99859342
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98189861
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97419729
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.96292750
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96040310
85* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95159270
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94795272
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93717709
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93683139
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93152450
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91286011
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.88335140
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86868192
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86540060
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86540060
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86540060
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85625053
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85248209
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85019579
99MYC_18940864_ChIP-ChIP_HL60_Human0.84835112
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84197886
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83247488
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83118556
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82528547
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82422788
105CHD1_26751641_Chip-Seq_LNCaP_Human0.80953488
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80007532
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79214560
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78883080
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77941383
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77572141
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.76862699
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76782463
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76109026
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75228054
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75167176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.82711975
2* MP0003111_abnormal_nucleus_morphology4.96351040
3MP0010094_abnormal_chromosome_stability4.67086454
4MP0004957_abnormal_blastocyst_morpholog4.51099050
5* MP0003077_abnormal_cell_cycle4.26488177
6MP0008057_abnormal_DNA_replication3.56272378
7MP0008058_abnormal_DNA_repair2.83648785
8MP0008007_abnormal_cellular_replicative2.75828425
9MP0008932_abnormal_embryonic_tissue2.73335766
10* MP0001730_embryonic_growth_arrest2.61812737
11MP0003123_paternal_imprinting2.60951138
12MP0000350_abnormal_cell_proliferation2.44519556
13MP0010352_gastrointestinal_tract_polyps2.20350081
14MP0001672_abnormal_embryogenesis/_devel2.01483072
15MP0005380_embryogenesis_phenotype2.01483072
16MP0010030_abnormal_orbit_morphology2.00967480
17MP0010307_abnormal_tumor_latency2.00194398
18MP0001697_abnormal_embryo_size1.97995487
19MP0008877_abnormal_DNA_methylation1.85628009
20MP0003718_maternal_effect1.85135455
21MP0002085_abnormal_embryonic_tissue1.83236716
22MP0003984_embryonic_growth_retardation1.76960207
23* MP0002080_prenatal_lethality1.75772960
24MP0002396_abnormal_hematopoietic_system1.74288453
25MP0002088_abnormal_embryonic_growth/wei1.73184029
26MP0005076_abnormal_cell_differentiation1.70926472
27MP0002084_abnormal_developmental_patter1.68004449
28MP0003786_premature_aging1.65637599
29MP0002877_abnormal_melanocyte_morpholog1.65366235
30MP0009697_abnormal_copulation1.58152352
31MP0000490_abnormal_crypts_of1.57397716
32MP0002086_abnormal_extraembryonic_tissu1.56592053
33MP0004197_abnormal_fetal_growth/weight/1.49697124
34MP0000313_abnormal_cell_death1.46594570
35MP0001346_abnormal_lacrimal_gland1.41387681
36* MP0002019_abnormal_tumor_incidence1.33448819
37MP0003121_genomic_imprinting1.31754140
38MP0002653_abnormal_ependyma_morphology1.31385288
39MP0003890_abnormal_embryonic-extraembry1.29492761
40MP0000537_abnormal_urethra_morphology1.29320745
41MP0009053_abnormal_anal_canal1.28937595
42MP0004808_abnormal_hematopoietic_stem1.27370120
43MP0003315_abnormal_perineum_morphology1.26551266
44MP0000566_synostosis1.25985031
45MP0003567_abnormal_fetal_cardiomyocyte1.25224220
46MP0003705_abnormal_hypodermis_morpholog1.24800971
47MP0003119_abnormal_digestive_system1.19984507
48MP0005397_hematopoietic_system_phenotyp1.16722151
49MP0001545_abnormal_hematopoietic_system1.16722151
50MP0002210_abnormal_sex_determination1.16579596
51MP0004185_abnormal_adipocyte_glucose1.15418310
52MP0002697_abnormal_eye_size1.15257601
53MP0002938_white_spotting1.14118615
54MP0006035_abnormal_mitochondrial_morpho1.13522807
55MP0001293_anophthalmia1.11075434
56MP0004133_heterotaxia1.09021936
57MP0005623_abnormal_meninges_morphology1.07345677
58MP0001849_ear_inflammation1.06489410
59MP0009333_abnormal_splenocyte_physiolog1.05345795
60MP0001145_abnormal_male_reproductive1.04342004
61MP0009672_abnormal_birth_weight1.03370589
62MP0001929_abnormal_gametogenesis1.03248303
63MP0006054_spinal_hemorrhage1.02896931
64MP0003937_abnormal_limbs/digits/tail_de1.00608518
65MP0002111_abnormal_tail_morphology0.99550832
66MP0003806_abnormal_nucleotide_metabolis0.97468918
67MP0000703_abnormal_thymus_morphology0.96136352
68MP0009278_abnormal_bone_marrow0.95975495
69MP0001661_extended_life_span0.91885071
70MP0000653_abnormal_sex_gland0.91713496
71MP0000678_abnormal_parathyroid_gland0.91353711
72MP0005023_abnormal_wound_healing0.90068063
73MP0001727_abnormal_embryo_implantation0.89767728
74MP0001915_intracranial_hemorrhage0.85576578
75MP0003942_abnormal_urinary_system0.85201563
76MP0003566_abnormal_cell_adhesion0.84598910
77MP0005621_abnormal_cell_physiology0.83024526
78MP0005384_cellular_phenotype0.82718371
79MP0005451_abnormal_body_composition0.82414988
80MP0003385_abnormal_body_wall0.82115179
81MP0002722_abnormal_immune_system0.81960509
82MP0000049_abnormal_middle_ear0.80204715
83MP0002160_abnormal_reproductive_system0.79257762
84MP0002089_abnormal_postnatal_growth/wei0.79150492
85MP0009703_decreased_birth_body0.78517472
86MP0000428_abnormal_craniofacial_morphol0.78494945
87MP0000858_altered_metastatic_potential0.77827894
88MP0002249_abnormal_larynx_morphology0.77619582
89MP0002796_impaired_skin_barrier0.77425422
90MP0000358_abnormal_cell_content/0.77014995
91MP0001119_abnormal_female_reproductive0.76699256
92MP0002398_abnormal_bone_marrow0.75969940
93MP0005389_reproductive_system_phenotype0.74870209
94MP0003941_abnormal_skin_development0.74680780
95MP0004264_abnormal_extraembryonic_tissu0.74374664
96MP0010234_abnormal_vibrissa_follicle0.72728715
97MP0000689_abnormal_spleen_morphology0.71303281
98MP0006036_abnormal_mitochondrial_physio0.71041004
99MP0003115_abnormal_respiratory_system0.70012964
100MP0003186_abnormal_redox_activity0.68298806
101MP0002132_abnormal_respiratory_system0.68037921
102MP0003656_abnormal_erythrocyte_physiolo0.67639749
103MP0003221_abnormal_cardiomyocyte_apopto0.67485801
104MP0002932_abnormal_joint_morphology0.67180264
105MP0000432_abnormal_head_morphology0.66339137
106MP0000477_abnormal_intestine_morphology0.66276854
107MP0000733_abnormal_muscle_development0.65832604
108MP0001529_abnormal_vocalization0.65502929
109MP0005257_abnormal_intraocular_pressure0.65202156
110MP0008789_abnormal_olfactory_epithelium0.64592922
111MP0002233_abnormal_nose_morphology0.64300663
112MP0001919_abnormal_reproductive_system0.64150566
113MP0002092_abnormal_eye_morphology0.63733820
114MP0001286_abnormal_eye_development0.63696369
115MP0003755_abnormal_palate_morphology0.63213114
116MP0005501_abnormal_skin_physiology0.62746228
117MP0003699_abnormal_female_reproductive0.61202957
118MP0003861_abnormal_nervous_system0.61029632
119MP0002925_abnormal_cardiovascular_devel0.60984449
120MP0004233_abnormal_muscle_weight0.60623982
121MP0003935_abnormal_craniofacial_develop0.60068094
122MP0005395_other_phenotype0.59919197
123MP0006292_abnormal_olfactory_placode0.59202539
124MP0002114_abnormal_axial_skeleton0.58103609
125MP0005394_taste/olfaction_phenotype0.57938235
126MP0005499_abnormal_olfactory_system0.57938235
127MP0002429_abnormal_blood_cell0.57597908
128MP0001881_abnormal_mammary_gland0.57135935
129MP0002161_abnormal_fertility/fecundity0.56442391
130MP0008770_decreased_survivor_rate0.56050067
131MP0000750_abnormal_muscle_regeneration0.53579118
132MP0003763_abnormal_thymus_physiology0.53526633

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.09605587
2Breast hypoplasia (HP:0003187)3.86231033
3Carpal bone hypoplasia (HP:0001498)3.76684397
4Patellar aplasia (HP:0006443)3.65988958
5Selective tooth agenesis (HP:0001592)3.58799517
6Chromsome breakage (HP:0040012)3.56783570
7Aplasia/Hypoplasia of the patella (HP:0006498)3.47002561
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46495136
9Reticulocytopenia (HP:0001896)3.42067746
10Ependymoma (HP:0002888)3.24211244
11Oral leukoplakia (HP:0002745)3.13031835
12Medulloblastoma (HP:0002885)3.11056426
13Degeneration of anterior horn cells (HP:0002398)3.10847679
14Abnormality of the anterior horn cell (HP:0006802)3.10847679
15Absent radius (HP:0003974)3.09189611
16Meckel diverticulum (HP:0002245)3.03787688
17Colon cancer (HP:0003003)3.03671347
18Impulsivity (HP:0100710)3.02083393
19Abnormality of cells of the erythroid lineage (HP:0012130)2.95248323
20Cortical dysplasia (HP:0002539)2.92634866
21Duodenal stenosis (HP:0100867)2.92509697
22Small intestinal stenosis (HP:0012848)2.92509697
23Abnormality of the ileum (HP:0001549)2.90511275
24Aplasia involving forearm bones (HP:0009822)2.88364150
25Absent forearm bone (HP:0003953)2.88364150
26Abnormal number of erythroid precursors (HP:0012131)2.84779597
27Abnormality of chromosome stability (HP:0003220)2.78967078
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.78940499
29Increased nuchal translucency (HP:0010880)2.78759553
30Microvesicular hepatic steatosis (HP:0001414)2.78144874
31Abnormality of the preputium (HP:0100587)2.77864337
32Abnormal lung lobation (HP:0002101)2.77341566
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74883841
34Progressive muscle weakness (HP:0003323)2.74637034
35Absent thumb (HP:0009777)2.73620527
36Rough bone trabeculation (HP:0100670)2.70732831
37Abnormality of the labia minora (HP:0012880)2.66168532
38Abnormal gallbladder physiology (HP:0012438)2.64488376
39Cholecystitis (HP:0001082)2.64488376
40Abnormality of glycolysis (HP:0004366)2.62680491
41Rhabdomyosarcoma (HP:0002859)2.59865974
42Myelodysplasia (HP:0002863)2.54552607
43Cerebral hypomyelination (HP:0006808)2.52964401
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49718993
45Abnormality of the duodenum (HP:0002246)2.45062443
46Ectopic kidney (HP:0000086)2.44280221
47Trismus (HP:0000211)2.42690971
48Proximal placement of thumb (HP:0009623)2.41803267
49Neoplasm of the pancreas (HP:0002894)2.39873167
50Agnosia (HP:0010524)2.39234416
51Abnormal number of incisors (HP:0011064)2.39139977
52Deviation of the thumb (HP:0009603)2.38259192
53Premature ovarian failure (HP:0008209)2.38196568
54High anterior hairline (HP:0009890)2.33400454
55Sloping forehead (HP:0000340)2.33158236
56Supernumerary spleens (HP:0009799)2.32428216
57Basal cell carcinoma (HP:0002671)2.27098669
58Horseshoe kidney (HP:0000085)2.26346413
59Cafe-au-lait spot (HP:0000957)2.26342526
60Abnormality of abdominal situs (HP:0011620)2.25990740
61Abdominal situs inversus (HP:0003363)2.25990740
62Increased serum pyruvate (HP:0003542)2.24589230
63Atresia of the external auditory canal (HP:0000413)2.22312221
64Facial hemangioma (HP:0000329)2.19118141
65Tracheoesophageal fistula (HP:0002575)2.18965202
66Aplasia/hypoplasia of the humerus (HP:0006507)2.18815090
67Bone marrow hypocellularity (HP:0005528)2.18573547
6811 pairs of ribs (HP:0000878)2.17248840
69Aplastic anemia (HP:0001915)2.17005487
70Abnormality of the umbilical cord (HP:0010881)2.16912379
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14740644
72Short 4th metacarpal (HP:0010044)2.14740644
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.14507111
74Small epiphyses (HP:0010585)2.13458825
75Hyperacusis (HP:0010780)2.11883262
76Abnormal umbilical cord blood vessels (HP:0011403)2.11238485
77Single umbilical artery (HP:0001195)2.11238485
78Abnormality of the fetal cardiovascular system (HP:0010948)2.11238485
79Multiple enchondromatosis (HP:0005701)2.08664441
80Short thumb (HP:0009778)2.07727905
81High pitched voice (HP:0001620)2.07533885
82Embryonal neoplasm (HP:0002898)2.06694140
83Macrocytic anemia (HP:0001972)2.06328646
84Astrocytoma (HP:0009592)2.04880607
85Abnormality of the astrocytes (HP:0100707)2.04880607
86Neoplasm of striated muscle (HP:0009728)2.04860599
87Premature graying of hair (HP:0002216)2.04393356
88Duplication of thumb phalanx (HP:0009942)2.03849982
89Missing ribs (HP:0000921)2.03058428
90Progressive external ophthalmoplegia (HP:0000590)2.02489719
91Hypoplastic pelvis (HP:0008839)2.01267939
92Cellular immunodeficiency (HP:0005374)2.00105119
93Squamous cell carcinoma (HP:0002860)1.99510705
94Secondary amenorrhea (HP:0000869)1.98898876
95Overlapping toe (HP:0001845)1.98888370
96Abnormality of reticulocytes (HP:0004312)1.98520186
97Insomnia (HP:0100785)1.97451651
98Abnormality of the carotid arteries (HP:0005344)1.96637183
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.95977179
100Nephroblastoma (Wilms tumor) (HP:0002667)1.95832121
101Microretrognathia (HP:0000308)1.94998393
102Triphalangeal thumb (HP:0001199)1.94943299
103Pallor (HP:0000980)1.94353683
104Glioma (HP:0009733)1.91906587
105Duplicated collecting system (HP:0000081)1.91294197
106Neoplasm of the colon (HP:0100273)1.91044516
107Choanal atresia (HP:0000453)1.90838576
108Cleft eyelid (HP:0000625)1.89682846
109Abnormality of the calcaneus (HP:0008364)1.89508685
110Septate vagina (HP:0001153)1.89283517
111Abnormal trabecular bone morphology (HP:0100671)1.89048302
112Prominent nose (HP:0000448)1.87532635
113Facial cleft (HP:0002006)1.87059624
114Abnormality of cochlea (HP:0000375)1.85573279
115Short humerus (HP:0005792)1.84875459
116Ragged-red muscle fibers (HP:0003200)1.84661580
117Embryonal renal neoplasm (HP:0011794)1.81489617
118Absent epiphyses (HP:0010577)1.80728732
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80728732
120Neoplasm of the oral cavity (HP:0100649)1.80141380
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78857496
122Abnormality of the proximal phalanges of the hand (HP:0009834)1.78295819
123Broad distal phalanx of finger (HP:0009836)1.76063651
124Ovarian neoplasm (HP:0100615)1.75257470
125Overriding aorta (HP:0002623)1.74996643
126Poikiloderma (HP:0001029)1.74414728
127Abnormality of chromosome segregation (HP:0002916)1.70405279
128Orthostatic hypotension (HP:0001278)1.65646681
129Urethral obstruction (HP:0000796)1.64202206
130Irregular epiphyses (HP:0010582)1.63189004
131Abnormality of the phalanges of the hallux (HP:0010057)1.63111043
132Ulnar bowing (HP:0003031)1.61771803
133Abnormality of DNA repair (HP:0003254)1.60699064
134Vaginal fistula (HP:0004320)1.59939945
135Nonimmune hydrops fetalis (HP:0001790)1.58458760
136Renal duplication (HP:0000075)1.58229214
137Ureteral duplication (HP:0000073)1.57790164
138Arteriovenous malformation (HP:0100026)1.55661366
139Entropion (HP:0000621)1.54983076
140Hypergonadotropic hypogonadism (HP:0000815)1.53644413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.34006005
2WEE14.26045763
3CDC73.95359050
4NEK23.45876772
5TTK3.05919493
6VRK22.75127158
7BRSK22.61752244
8EIF2AK12.60729024
9NEK12.50259311
10SMG12.48822011
11BRSK12.46984298
12* PLK12.19310391
13EEF2K2.15549717
14PLK42.13963450
15TESK22.12295494
16CDK122.10669152
17TSSK61.89596719
18AURKB1.89186656
19MAP3K101.86241345
20SRPK11.74096139
21PLK31.70891947
22CDK71.65620298
23RPS6KB21.54397573
24CHEK21.52249816
25ATR1.44153714
26* AURKA1.42539555
27CDK41.39574062
28* MAP3K81.36386272
29MKNK11.36317333
30STK41.34466423
31MELK1.34313960
32RPS6KA41.34234797
33EPHA21.33731078
34CHEK11.30765496
35PASK1.30002126
36PAK41.25316603
37DYRK31.21883992
38TAF11.20882813
39ACVR1B1.20409157
40TLK11.18926067
41VRK11.17257511
42NME21.12582876
43LATS21.09760352
44NME11.05157349
45CCNB11.02272362
46IRAK30.99443055
47TESK10.96061661
48MKNK20.93625491
49STK160.92229138
50EIF2AK30.91214976
51STK30.90750392
52PKN20.90411995
53CDK20.87481278
54ATM0.83259488
55BRAF0.80393074
56LRRK20.78313469
57SCYL20.77460505
58CDK60.76765819
59ALK0.73381839
60MST1R0.71955901
61* PAK10.71803233
62CDK10.71341229
63BRD40.71114171
64* STK100.70436623
65TGFBR10.67654490
66PBK0.65286451
67TRIB30.63135493
68MST40.58879701
69MTOR0.58348564
70PIM10.57467548
71PRKCI0.56592390
72ZAK0.56456231
73KDR0.54751686
74MAP3K110.54573497
75AKT20.52808868
76CSNK2A10.52547516
77CLK10.52510396
78CSNK2A20.51626039
79STK38L0.51106361
80LATS10.50111897
81CDK180.49605954
82FLT30.48427197
83SIK10.47550879
84MAPK110.46756987
85CDK80.46569429
86CDK90.46415979
87MAP4K10.43610779
88PNCK0.43508463
89MAPKAPK30.42423013
90MARK30.41530594
91EIF2AK20.41137807
92CDK140.40729377
93MET0.39966096
94TRIM280.38745819
95GRK60.36047734
96CSNK1E0.34389991
97ERBB40.32568064
98ARAF0.31696208
99UHMK10.31479318
100TAOK20.31228146
101PTK20.30349580
102ICK0.29934132
103PAK20.29926745
104BMX0.29795853
105PDK30.28672593
106PDK40.28672593
107PDK20.28404867
108RAF10.28328105
109PRKDC0.27688211
110RPS6KA10.27474234
111MAP3K90.27370053
112CDK11A0.26151403
113RPS6KA50.24218878
114MAPK140.24009614
115CSNK1G30.23839832
116PIM20.23377599
117MAP2K30.22770703
118CDK150.22460093
119DAPK10.21881593
120LIMK10.21476490
121ILK0.20107054
122FGFR10.19280843
123AKT10.19221768

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82098039
2Mismatch repair_Homo sapiens_hsa034304.11302308
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54185852
4Spliceosome_Homo sapiens_hsa030403.46730348
5RNA transport_Homo sapiens_hsa030133.45014996
6* Cell cycle_Homo sapiens_hsa041103.33899758
7Base excision repair_Homo sapiens_hsa034103.24914544
8Homologous recombination_Homo sapiens_hsa034403.02145467
9RNA polymerase_Homo sapiens_hsa030202.91680134
10Ribosome_Homo sapiens_hsa030102.77012795
11Nucleotide excision repair_Homo sapiens_hsa034202.74339464
12One carbon pool by folate_Homo sapiens_hsa006702.68911393
13Proteasome_Homo sapiens_hsa030502.67608320
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57964688
15Fanconi anemia pathway_Homo sapiens_hsa034602.31221804
16Pyrimidine metabolism_Homo sapiens_hsa002402.23685465
17mRNA surveillance pathway_Homo sapiens_hsa030151.98030698
18RNA degradation_Homo sapiens_hsa030181.94119680
19Non-homologous end-joining_Homo sapiens_hsa034501.93578332
20p53 signaling pathway_Homo sapiens_hsa041151.93223978
21Basal transcription factors_Homo sapiens_hsa030221.84113321
22* Oocyte meiosis_Homo sapiens_hsa041141.42205325
23* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37271251
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34279115
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29569519
26Epstein-Barr virus infection_Homo sapiens_hsa051691.22274323
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20505389
28Pyruvate metabolism_Homo sapiens_hsa006201.19484384
29Vitamin B6 metabolism_Homo sapiens_hsa007501.16953638
30Purine metabolism_Homo sapiens_hsa002301.15591463
31Systemic lupus erythematosus_Homo sapiens_hsa053221.15513938
32Viral carcinogenesis_Homo sapiens_hsa052031.11006802
33Biosynthesis of amino acids_Homo sapiens_hsa012301.04860141
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01784590
35Pentose phosphate pathway_Homo sapiens_hsa000300.97195054
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.94795516
37MicroRNAs in cancer_Homo sapiens_hsa052060.93261921
38Fatty acid elongation_Homo sapiens_hsa000620.92379177
39HTLV-I infection_Homo sapiens_hsa051660.92072330
40Steroid biosynthesis_Homo sapiens_hsa001000.88839219
41Selenocompound metabolism_Homo sapiens_hsa004500.86982847
42Herpes simplex infection_Homo sapiens_hsa051680.83783151
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80869461
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78815173
45Antigen processing and presentation_Homo sapiens_hsa046120.76399616
46Thyroid cancer_Homo sapiens_hsa052160.76367257
47Hippo signaling pathway_Homo sapiens_hsa043900.74923085
48Small cell lung cancer_Homo sapiens_hsa052220.72889414
49Basal cell carcinoma_Homo sapiens_hsa052170.71476808
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67679561
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.65063136
52Folate biosynthesis_Homo sapiens_hsa007900.63995071
53Notch signaling pathway_Homo sapiens_hsa043300.61709056
54Parkinsons disease_Homo sapiens_hsa050120.61358836
55Bladder cancer_Homo sapiens_hsa052190.59771312
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.59460950
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59292141
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58605312
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58338573
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56863154
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56676875
62Carbon metabolism_Homo sapiens_hsa012000.55092528
63Colorectal cancer_Homo sapiens_hsa052100.54355291
64Arginine and proline metabolism_Homo sapiens_hsa003300.54037362
65TGF-beta signaling pathway_Homo sapiens_hsa043500.52562493
66Apoptosis_Homo sapiens_hsa042100.52500332
67Sulfur relay system_Homo sapiens_hsa041220.49678601
68Hedgehog signaling pathway_Homo sapiens_hsa043400.48991116
69Glutathione metabolism_Homo sapiens_hsa004800.48530315
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47130151
71Chronic myeloid leukemia_Homo sapiens_hsa052200.46948712
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46650558
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43888000
74Adherens junction_Homo sapiens_hsa045200.43818423
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43370232
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.43167574
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39720362
78Legionellosis_Homo sapiens_hsa051340.39162344
79Alcoholism_Homo sapiens_hsa050340.37347583
80Hepatitis B_Homo sapiens_hsa051610.36714651
81Metabolic pathways_Homo sapiens_hsa011000.36306928
82HIF-1 signaling pathway_Homo sapiens_hsa040660.36232529
83Arginine biosynthesis_Homo sapiens_hsa002200.35639159
84Oxidative phosphorylation_Homo sapiens_hsa001900.35284680
85Fructose and mannose metabolism_Homo sapiens_hsa000510.34836046
86Shigellosis_Homo sapiens_hsa051310.34547110
87mTOR signaling pathway_Homo sapiens_hsa041500.34533841
88Protein export_Homo sapiens_hsa030600.34348362
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32370281
90Pathways in cancer_Homo sapiens_hsa052000.32341490
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30045907
92Fatty acid metabolism_Homo sapiens_hsa012120.29109153
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28327884
94N-Glycan biosynthesis_Homo sapiens_hsa005100.25861199
95Viral myocarditis_Homo sapiens_hsa054160.24491186
96Tight junction_Homo sapiens_hsa045300.23546943
97Lysine degradation_Homo sapiens_hsa003100.23290954
98Primary immunodeficiency_Homo sapiens_hsa053400.22903024
99AMPK signaling pathway_Homo sapiens_hsa041520.22868010
100Galactose metabolism_Homo sapiens_hsa000520.22371657
101Prostate cancer_Homo sapiens_hsa052150.22047732
102Huntingtons disease_Homo sapiens_hsa050160.22009404
103Non-small cell lung cancer_Homo sapiens_hsa052230.21935794
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21907933
105Acute myeloid leukemia_Homo sapiens_hsa052210.21264321
106Phenylalanine metabolism_Homo sapiens_hsa003600.19613720
107Wnt signaling pathway_Homo sapiens_hsa043100.19010943
108Proteoglycans in cancer_Homo sapiens_hsa052050.18881882
109Propanoate metabolism_Homo sapiens_hsa006400.18085054
110Influenza A_Homo sapiens_hsa051640.17036793
111Melanoma_Homo sapiens_hsa052180.16923255
112Renin-angiotensin system_Homo sapiens_hsa046140.16919956
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16689181
114Pancreatic cancer_Homo sapiens_hsa052120.16605704
115Alzheimers disease_Homo sapiens_hsa050100.16051094
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15963622
117Endometrial cancer_Homo sapiens_hsa052130.15228309
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15161335
119Measles_Homo sapiens_hsa051620.13600715
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.10933446
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.09195676
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08038277

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