PLGLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)8.20671436
2glyoxylate metabolic process (GO:0046487)7.99335865
3exogenous drug catabolic process (GO:0042738)7.85980808
4epoxygenase P450 pathway (GO:0019373)7.01933045
5omega-hydroxylase P450 pathway (GO:0097267)6.89826748
6serine family amino acid catabolic process (GO:0009071)6.82267146
7oxidative demethylation (GO:0070989)6.21206430
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.98073603
9L-phenylalanine catabolic process (GO:0006559)5.98073603
10complement activation, alternative pathway (GO:0006957)5.86321848
11regulation of fibrinolysis (GO:0051917)5.84352545
12glycine metabolic process (GO:0006544)5.63827271
13bile acid biosynthetic process (GO:0006699)5.52574812
14negative regulation of fibrinolysis (GO:0051918)5.51812542
15phenylpropanoid metabolic process (GO:0009698)5.43125023
16regulation of protein activation cascade (GO:2000257)5.29814697
17ethanol oxidation (GO:0006069)5.12578030
18aromatic amino acid family catabolic process (GO:0009074)5.06907858
19pyrimidine nucleobase catabolic process (GO:0006208)4.99751883
20drug metabolic process (GO:0017144)4.93948109
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.87339327
22L-phenylalanine metabolic process (GO:0006558)4.87339327
23regulation of complement activation (GO:0030449)4.78197860
24cellular glucuronidation (GO:0052695)4.71428278
25protein carboxylation (GO:0018214)4.64822495
26peptidyl-glutamic acid carboxylation (GO:0017187)4.64822495
27serine family amino acid metabolic process (GO:0009069)4.64621755
28urea metabolic process (GO:0019627)4.56504519
29glucuronate metabolic process (GO:0019585)4.54282297
30uronic acid metabolic process (GO:0006063)4.54282297
31S-adenosylmethionine metabolic process (GO:0046500)4.53274172
32bile acid metabolic process (GO:0008206)4.52869999
33fibrinolysis (GO:0042730)4.36046870
34bile acid and bile salt transport (GO:0015721)4.34448671
35alkaloid metabolic process (GO:0009820)4.31446868
36indole-containing compound catabolic process (GO:0042436)4.25871640
37indolalkylamine catabolic process (GO:0046218)4.25871640
38tryptophan catabolic process (GO:0006569)4.25871640
39heme transport (GO:0015886)4.24212343
40blood coagulation, intrinsic pathway (GO:0007597)4.20334401
41cellular ketone body metabolic process (GO:0046950)4.15143408
42nucleobase catabolic process (GO:0046113)4.12664277
43nitrogen cycle metabolic process (GO:0071941)4.03388531
44regulation of triglyceride catabolic process (GO:0010896)3.92552970
45negative regulation of sterol transport (GO:0032372)3.91917016
46negative regulation of cholesterol transport (GO:0032375)3.91917016
47arginine metabolic process (GO:0006525)3.86670662
48ethanol metabolic process (GO:0006067)3.85951685
49alpha-amino acid catabolic process (GO:1901606)3.84036675
50triglyceride homeostasis (GO:0070328)3.74686474
51acylglycerol homeostasis (GO:0055090)3.74686474
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72714183
53disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71367652
54killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71367652
55aldehyde catabolic process (GO:0046185)3.70262979
56amino-acid betaine metabolic process (GO:0006577)3.70163609
57urea cycle (GO:0000050)3.68880509
58serine family amino acid biosynthetic process (GO:0009070)3.64521495
59ketone body metabolic process (GO:1902224)3.62880369
60imidazole-containing compound metabolic process (GO:0052803)3.57266342
61water-soluble vitamin biosynthetic process (GO:0042364)3.55179606
62tryptophan metabolic process (GO:0006568)3.52580982
63protein activation cascade (GO:0072376)3.50176000
64steroid catabolic process (GO:0006706)3.46617467
65regulation of humoral immune response (GO:0002920)3.44781117
66amine catabolic process (GO:0009310)3.36234621
67cellular biogenic amine catabolic process (GO:0042402)3.36234621
68hormone catabolic process (GO:0042447)3.34276454
69aromatic amino acid family metabolic process (GO:0009072)3.31144984
70complement activation (GO:0006956)3.30638341
71regulation of glucokinase activity (GO:0033131)3.27370863
72regulation of hexokinase activity (GO:1903299)3.27370863
73opsonization (GO:0008228)3.25077802
74cellular amino acid catabolic process (GO:0009063)3.24224612
75regulation of plasminogen activation (GO:0010755)3.21085113
76negative regulation of blood coagulation (GO:0030195)3.12981371
77negative regulation of hemostasis (GO:1900047)3.12981371
78kynurenine metabolic process (GO:0070189)3.12444041
79cytolysis (GO:0019835)3.11496124
80complement activation, classical pathway (GO:0006958)3.08148263
81sodium-independent organic anion transport (GO:0043252)3.07457286
82L-methionine biosynthetic process (GO:0071265)3.05366701
83amino acid salvage (GO:0043102)3.05366701
84L-methionine salvage (GO:0071267)3.05366701
85protein-lipid complex remodeling (GO:0034368)3.04259055
86macromolecular complex remodeling (GO:0034367)3.04259055
87plasma lipoprotein particle remodeling (GO:0034369)3.04259055
88tyrosine metabolic process (GO:0006570)3.03995977
89iron coordination entity transport (GO:1901678)3.03795100
90peptidyl-glutamic acid modification (GO:0018200)3.02461341
91indolalkylamine metabolic process (GO:0006586)3.02239003
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01998590
93cysteine metabolic process (GO:0006534)3.01210931
94glutamate metabolic process (GO:0006536)2.99655165
95arginine catabolic process (GO:0006527)2.99469691
96dopamine transport (GO:0015872)2.98476315
97negative regulation of wound healing (GO:0061045)2.94860943
98negative regulation of protein activation cascade (GO:2000258)2.93614646
99coenzyme catabolic process (GO:0009109)2.93461425
100behavioral response to nicotine (GO:0035095)2.91539885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse3.86720609
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67299951
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63378877
4VDR_22108803_ChIP-Seq_LS180_Human3.34554665
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14828726
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05485647
7ZNF274_21170338_ChIP-Seq_K562_Hela2.80825677
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52727315
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42815372
10IGF1R_20145208_ChIP-Seq_DFB_Human2.41632425
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36639978
12IRF1_19129219_ChIP-ChIP_H3396_Human2.32652116
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25972589
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.20846749
15EZH2_22144423_ChIP-Seq_EOC_Human2.12170206
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.09778903
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06976306
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06828725
19FUS_26573619_Chip-Seq_HEK293_Human2.02817906
20ER_23166858_ChIP-Seq_MCF-7_Human2.01320821
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94211923
22GBX2_23144817_ChIP-Seq_PC3_Human1.94118834
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92105435
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.91973552
25TAF15_26573619_Chip-Seq_HEK293_Human1.86215033
26P300_19829295_ChIP-Seq_ESCs_Human1.82730841
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80819452
28EWS_26573619_Chip-Seq_HEK293_Human1.77046788
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74180401
30BCAT_22108803_ChIP-Seq_LS180_Human1.64579630
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.61454161
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58784078
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.58082936
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57763061
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56119555
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53578495
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.51787590
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51766909
39HTT_18923047_ChIP-ChIP_STHdh_Human1.49343316
40NANOG_19829295_ChIP-Seq_ESCs_Human1.49100913
41SOX2_19829295_ChIP-Seq_ESCs_Human1.49100913
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45976195
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44918497
44REST_21632747_ChIP-Seq_MESCs_Mouse1.43673449
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42523375
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40775820
47STAT3_23295773_ChIP-Seq_U87_Human1.40603198
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38271094
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36265131
50SMAD4_21799915_ChIP-Seq_A2780_Human1.36047695
51CBP_20019798_ChIP-Seq_JUKART_Human1.35596011
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35596011
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.33449159
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32499198
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32377698
56TCF4_22108803_ChIP-Seq_LS180_Human1.30793746
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29806426
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29641700
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24186810
60TCF4_23295773_ChIP-Seq_U87_Human1.22687230
61NCOR_22424771_ChIP-Seq_293T_Human1.22189770
62AR_20517297_ChIP-Seq_VCAP_Human1.19443844
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.18061470
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.16526822
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.16009404
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.15795655
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14666282
68TP53_22573176_ChIP-Seq_HFKS_Human1.14464995
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13776804
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09630155
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.08766287
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08573336
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08562346
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.07972379
75* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07953840
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.07858581
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07298967
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07229173
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.07229173
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06164340
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06164340
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06124210
83AR_25329375_ChIP-Seq_VCAP_Human1.06051852
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.05471316
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04320891
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.04009988
87RUNX2_22187159_ChIP-Seq_PCA_Human1.03963165
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03229873
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03174245
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02360572
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01093954
92RNF2_27304074_Chip-Seq_NSC_Mouse1.00073760
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97120626
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.95377353
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95069972
96ERG_20517297_ChIP-Seq_VCAP_Human0.94010663
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93355158
98CBP_21632823_ChIP-Seq_H3396_Human0.93182987
99MYC_19829295_ChIP-Seq_ESCs_Human0.92398427
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92012033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.81790650
2MP0005360_urolithiasis4.64180599
3MP0005085_abnormal_gallbladder_physiolo4.35611224
4MP0002876_abnormal_thyroid_physiology4.14605269
5MP0008875_abnormal_xenobiotic_pharmacok4.05624979
6MP0002138_abnormal_hepatobiliary_system3.87808212
7MP0005365_abnormal_bile_salt3.69852070
8MP0003195_calcinosis3.67106634
9MP0003252_abnormal_bile_duct3.41485127
10MP0003880_abnormal_central_pattern3.11380553
11MP0009697_abnormal_copulation2.90357150
12MP0006276_abnormal_autonomic_nervous2.14769325
13MP0003787_abnormal_imprinting2.11710354
14MP0003868_abnormal_feces_composition2.08430169
15MP0001666_abnormal_nutrient_absorption1.86535538
16MP0004133_heterotaxia1.85093910
17MP0002653_abnormal_ependyma_morphology1.82188768
18MP0006072_abnormal_retinal_apoptosis1.80844309
19MP0001984_abnormal_olfaction1.75001786
20MP0001764_abnormal_homeostasis1.72357418
21MP0000372_irregular_coat_pigmentation1.71079030
22MP0005332_abnormal_amino_acid1.64415054
23MP0003806_abnormal_nucleotide_metabolis1.63624188
24MP0005551_abnormal_eye_electrophysiolog1.61352718
25MP0008877_abnormal_DNA_methylation1.61211068
26MP0010329_abnormal_lipoprotein_level1.51446840
27MP0008995_early_reproductive_senescence1.41756896
28MP0004142_abnormal_muscle_tone1.41671826
29MP0008789_abnormal_olfactory_epithelium1.41559344
30MP0001986_abnormal_taste_sensitivity1.40685313
31MP0003123_paternal_imprinting1.34863804
32MP0006292_abnormal_olfactory_placode1.32574939
33MP0004019_abnormal_vitamin_homeostasis1.21713107
34MP0003121_genomic_imprinting1.21459281
35MP0009764_decreased_sensitivity_to1.17309243
36MP0004885_abnormal_endolymph1.13855937
37MP0008872_abnormal_physiological_respon1.13613544
38MP0000778_abnormal_nervous_system1.06279554
39MP0005423_abnormal_somatic_nervous1.04484608
40MP0002254_reproductive_system_inflammat1.02746446
41MP0003283_abnormal_digestive_organ1.02223810
42MP0002118_abnormal_lipid_homeostasis1.01013742
43MP0005499_abnormal_olfactory_system0.96430192
44MP0005394_taste/olfaction_phenotype0.96430192
45MP0002234_abnormal_pharynx_morphology0.95675133
46MP0003122_maternal_imprinting0.94904420
47MP0000609_abnormal_liver_physiology0.94856878
48MP0010386_abnormal_urinary_bladder0.94239964
49MP0002928_abnormal_bile_duct0.91432142
50MP0002638_abnormal_pupillary_reflex0.90607094
51MP0001293_anophthalmia0.89675305
52MP0002837_dystrophic_cardiac_calcinosis0.89164061
53MP0002282_abnormal_trachea_morphology0.89161880
54MP0005410_abnormal_fertilization0.86309583
55MP0005645_abnormal_hypothalamus_physiol0.85978865
56MP0005253_abnormal_eye_physiology0.84393293
57MP0002102_abnormal_ear_morphology0.83773267
58MP0005646_abnormal_pituitary_gland0.81300754
59MP0001485_abnormal_pinna_reflex0.80937799
60MP0009745_abnormal_behavioral_response0.80922197
61MP0004742_abnormal_vestibular_system0.78723210
62MP0003959_abnormal_lean_body0.78687209
63MP0008775_abnormal_heart_ventricle0.78274424
64MP0005408_hypopigmentation0.78148195
65MP0005395_other_phenotype0.77680911
66MP0002160_abnormal_reproductive_system0.77347625
67MP0001501_abnormal_sleep_pattern0.76836052
68MP0002272_abnormal_nervous_system0.76236501
69MP0003718_maternal_effect0.74426564
70MP0003656_abnormal_erythrocyte_physiolo0.74067460
71MP0005266_abnormal_metabolism0.74025626
72MP0005084_abnormal_gallbladder_morpholo0.73857463
73MP0005195_abnormal_posterior_eye0.73772541
74MP0010368_abnormal_lymphatic_system0.73761839
75MP0001486_abnormal_startle_reflex0.72445355
76MP0002132_abnormal_respiratory_system0.70720825
77MP0003890_abnormal_embryonic-extraembry0.69816009
78MP0001968_abnormal_touch/_nociception0.68972508
79MP0004859_abnormal_synaptic_plasticity0.68316021
80MP0001440_abnormal_grooming_behavior0.67623046
81MP0000631_abnormal_neuroendocrine_gland0.67395740
82MP0002067_abnormal_sensory_capabilities0.66765972
83MP0005389_reproductive_system_phenotype0.65933676
84MP0002822_catalepsy0.65718227
85MP0006036_abnormal_mitochondrial_physio0.64906372
86MP0009765_abnormal_xenobiotic_induced0.64445711
87MP0008961_abnormal_basal_metabolism0.63494509
88MP0009379_abnormal_foot_pigmentation0.63027240
89MP0003011_delayed_dark_adaptation0.60852294
90MP0002168_other_aberrant_phenotype0.59962010
91MP0005319_abnormal_enzyme/_coenzyme0.58323397
92MP0002938_white_spotting0.57978578
93MP0004924_abnormal_behavior0.57424557
94MP0005386_behavior/neurological_phenoty0.57424557
95MP0003638_abnormal_response/metabolism_0.57284793
96MP0005376_homeostasis/metabolism_phenot0.56500832
97MP0002971_abnormal_brown_adipose0.55949425
98MP0009642_abnormal_blood_homeostasis0.55827975
99MP0001919_abnormal_reproductive_system0.55785869
100MP0000639_abnormal_adrenal_gland0.55308564

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.21399261
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.99115681
3Deep venous thrombosis (HP:0002625)5.87361061
4Complement deficiency (HP:0004431)5.29432317
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.19504034
6Hyperlipoproteinemia (HP:0010980)4.74286125
7Hypobetalipoproteinemia (HP:0003563)4.43176842
8Hyperglycinemia (HP:0002154)4.32379790
9Joint hemorrhage (HP:0005261)3.92900402
10Conjugated hyperbilirubinemia (HP:0002908)3.92759105
11Fair hair (HP:0002286)3.76614656
12Abnormality of pyrimidine metabolism (HP:0004353)3.75407475
13Abnormality of complement system (HP:0005339)3.72470557
14Intrahepatic cholestasis (HP:0001406)3.64863433
15Chronic hepatic failure (HP:0100626)3.62186872
16Abnormality of methionine metabolism (HP:0010901)3.34653772
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10500915
18Systemic lupus erythematosus (HP:0002725)2.97872795
19Abnormal biliary tract physiology (HP:0012439)2.97134580
20Bile duct proliferation (HP:0001408)2.97134580
21Abnormality of glycine metabolism (HP:0010895)2.90086608
22Abnormality of serine family amino acid metabolism (HP:0010894)2.90086608
23Generalized hypopigmentation of hair (HP:0011358)2.82199496
24Reduced antithrombin III activity (HP:0001976)2.80304479
25Abnormality of serum amino acid levels (HP:0003112)2.79103900
26Hyperglycinuria (HP:0003108)2.66602060
27Pancreatic fibrosis (HP:0100732)2.62737795
28Congenital stationary night blindness (HP:0007642)2.59355497
29Spontaneous abortion (HP:0005268)2.59189829
30Abnormal rod and cone electroretinograms (HP:0008323)2.58524315
31Osteomalacia (HP:0002749)2.56850221
32Molar tooth sign on MRI (HP:0002419)2.53941989
33Abnormality of midbrain morphology (HP:0002418)2.53941989
34B lymphocytopenia (HP:0010976)2.49080074
35Thyroid-stimulating hormone excess (HP:0002925)2.48502291
36Methylmalonic acidemia (HP:0002912)2.47669721
37Thyroiditis (HP:0100646)2.46944778
38Septo-optic dysplasia (HP:0100842)2.44628267
39Xanthomatosis (HP:0000991)2.35308993
40Acute encephalopathy (HP:0006846)2.33983023
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.28984209
42True hermaphroditism (HP:0010459)2.28510837
43Nephronophthisis (HP:0000090)2.27981056
44Abnormality of the intrinsic pathway (HP:0010989)2.27815488
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21969797
46Optic nerve hypoplasia (HP:0000609)2.21885552
47Abnormality of B cell number (HP:0010975)2.18166794
48Glomerulonephritis (HP:0000099)2.16131369
49Abnormality of urine glucose concentration (HP:0011016)2.15306082
50Glycosuria (HP:0003076)2.15306082
51Abolished electroretinogram (ERG) (HP:0000550)2.15155726
52Delayed CNS myelination (HP:0002188)2.14251162
53Metaphyseal dysplasia (HP:0100255)2.13536521
54Hypochromic microcytic anemia (HP:0004840)2.13430486
55Dyskinesia (HP:0100660)2.13147749
56Abnormality of the common coagulation pathway (HP:0010990)2.10136799
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09958896
58Medial flaring of the eyebrow (HP:0010747)2.08358597
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07356223
60Recurrent gram-negative bacterial infections (HP:0005420)2.07015325
61Fat malabsorption (HP:0002630)2.06905295
62Hyperphosphaturia (HP:0003109)2.04907353
63Retinal dysplasia (HP:0007973)2.03066153
64Cerebral edema (HP:0002181)2.02662171
65Hyperalaninemia (HP:0003348)2.01840580
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01840580
67Abnormality of alanine metabolism (HP:0010916)2.01840580
68Renal cortical cysts (HP:0000803)2.01829094
69Broad-based gait (HP:0002136)2.00985555
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.00959670
71Lethargy (HP:0001254)2.00102323
72Epidermoid cyst (HP:0200040)1.97504181
73Pancreatic cysts (HP:0001737)1.95842700
74Volvulus (HP:0002580)1.94365070
75Abnormality of the fovea (HP:0000493)1.92028071
76Abnormality of nucleobase metabolism (HP:0010932)1.85571010
77Hypolipoproteinemia (HP:0010981)1.84524953
78Generalized aminoaciduria (HP:0002909)1.83129207
79Neonatal hypoglycemia (HP:0001998)1.82844134
80Abnormality of vitamin metabolism (HP:0100508)1.82776928
81Abnormality of the renal cortex (HP:0011035)1.82067400
82Abnormality of the renal medulla (HP:0100957)1.82002097
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81633506
84Optic disc pallor (HP:0000543)1.79728990
85Hyperammonemia (HP:0001987)1.79686317
86Neonatal respiratory distress (HP:0002643)1.79340988
87Progressive macrocephaly (HP:0004481)1.78007315
88Acute necrotizing encephalopathy (HP:0006965)1.77722862
89Pendular nystagmus (HP:0012043)1.77394469
90Methylmalonic aciduria (HP:0012120)1.77309477
91Pulmonary embolism (HP:0002204)1.76621428
92Hypoproteinemia (HP:0003075)1.76437275
93Metabolic acidosis (HP:0001942)1.74309495
94Ketosis (HP:0001946)1.73496534
95Increased serum pyruvate (HP:0003542)1.73349832
96Bony spicule pigmentary retinopathy (HP:0007737)1.73080256
97Enlarged kidneys (HP:0000105)1.72649872
98Type II lissencephaly (HP:0007260)1.72247733
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71998946
100Cerebellar dysplasia (HP:0007033)1.71851369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.11292752
2ZAK3.39834503
3PINK13.08840961
4CASK3.06535875
5WNK32.63695971
6TXK2.44952614
7DYRK32.44482230
8NUAK12.34021401
9FGFR22.27908475
10WNK42.17369695
11TLK11.87052591
12TAF11.86862962
13MAP2K71.84337549
14NTRK31.84124728
15STK161.82923597
16EPHA31.79156085
17MUSK1.77775991
18PIK3CG1.75554669
19CAMKK21.72943564
20MARK11.69998443
21EIF2AK31.62961434
22MAP3K41.52932918
23MAPK131.52561509
24TAOK31.51366519
25ADRBK21.48593924
26BCR1.41014487
27BMPR1B1.39805110
28PAK31.39135289
29DYRK21.28574330
30MAP4K21.21679562
31BCKDK1.20134623
32VRK11.19933486
33PIK3CA1.18475597
34TIE11.02111611
35INSRR0.99638064
36PBK0.99260963
37IRAK10.94482689
38GRK60.93362549
39ICK0.91920159
40ACVR1B0.88264064
41CSNK1G20.88243204
42TRIM280.85721436
43BRSK20.82789039
44FES0.81158732
45TYRO30.81051132
46PRKCG0.80410265
47DYRK1A0.79895833
48EPHA40.79306522
49MAP3K120.79289533
50KIT0.78262805
51MAP2K40.77944513
52PRKCE0.77792845
53NLK0.77574328
54STK390.76072713
55PRKACA0.74480430
56STK38L0.70929090
57ITK0.70908895
58DAPK20.70041619
59MAP3K70.65956759
60PRKACG0.65124821
61GRK10.64909853
62SGK20.59867890
63RPS6KA60.59694849
64FGFR30.58293957
65ERBB30.58086608
66OXSR10.57903647
67PKN10.57143228
68STK110.55921807
69VRK20.54815820
70CSNK1G10.54752518
71STK30.53030057
72MAPK150.52899924
73AKT30.52500355
74PRKG10.51032926
75TEC0.50021499
76PRKACB0.49556791
77MARK30.49520239
78RPS6KA50.49038477
79OBSCN0.45822947
80CSNK1G30.44226583
81PRKCQ0.43618260
82RPS6KC10.43582490
83RPS6KL10.43582490
84SGK4940.42931998
85SGK2230.42931998
86CCNB10.42491685
87MAPK40.40750634
88CAMKK10.40393096
89PRKCA0.40089491
90CSNK1D0.40080393
91MAPK110.39897906
92BTK0.39877110
93TNIK0.39336293
94ABL20.39212329
95ERBB20.39147196
96MAP2K20.38209789
97IKBKE0.37572862
98CDK50.37385709
99PLK30.36469124
100PLK20.35661110

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.24600768
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.12507583
3Caffeine metabolism_Homo sapiens_hsa002323.64456307
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.25157584
5Retinol metabolism_Homo sapiens_hsa008303.21155872
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12382137
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.11434633
8Complement and coagulation cascades_Homo sapiens_hsa046102.98385765
9Chemical carcinogenesis_Homo sapiens_hsa052042.72178881
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.64921602
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60414682
12Linoleic acid metabolism_Homo sapiens_hsa005912.31567393
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30338917
14Phenylalanine metabolism_Homo sapiens_hsa003602.19045432
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18434502
16Butanoate metabolism_Homo sapiens_hsa006502.16052168
17Arginine biosynthesis_Homo sapiens_hsa002202.08292241
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98157273
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.96985674
20Tryptophan metabolism_Homo sapiens_hsa003801.92615519
21Fatty acid degradation_Homo sapiens_hsa000711.92170023
22Tyrosine metabolism_Homo sapiens_hsa003501.84945789
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84814740
24Bile secretion_Homo sapiens_hsa049761.66896164
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58412701
26Peroxisome_Homo sapiens_hsa041461.50903426
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49566467
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48148777
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.43066757
30Arachidonic acid metabolism_Homo sapiens_hsa005901.14757384
31Histidine metabolism_Homo sapiens_hsa003401.13954357
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10062954
33Starch and sucrose metabolism_Homo sapiens_hsa005001.07016521
34Sulfur relay system_Homo sapiens_hsa041221.05839017
35beta-Alanine metabolism_Homo sapiens_hsa004101.05074588
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.95243020
37PPAR signaling pathway_Homo sapiens_hsa033200.95023044
38Propanoate metabolism_Homo sapiens_hsa006400.94469203
39Oxidative phosphorylation_Homo sapiens_hsa001900.92527286
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89563520
41One carbon pool by folate_Homo sapiens_hsa006700.89412402
42Fat digestion and absorption_Homo sapiens_hsa049750.86884390
43Pyruvate metabolism_Homo sapiens_hsa006200.86106950
44Parkinsons disease_Homo sapiens_hsa050120.85433826
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84475906
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.83604892
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83465404
48Nitrogen metabolism_Homo sapiens_hsa009100.77910792
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76952947
50Arginine and proline metabolism_Homo sapiens_hsa003300.76254717
51Non-homologous end-joining_Homo sapiens_hsa034500.70562605
52Staphylococcus aureus infection_Homo sapiens_hsa051500.69515539
53Selenocompound metabolism_Homo sapiens_hsa004500.66507207
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65453115
55Nicotine addiction_Homo sapiens_hsa050330.64374022
56ABC transporters_Homo sapiens_hsa020100.59962593
57Metabolic pathways_Homo sapiens_hsa011000.59306506
58Vitamin B6 metabolism_Homo sapiens_hsa007500.55511213
59Biosynthesis of amino acids_Homo sapiens_hsa012300.53422111
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52777367
61Basal transcription factors_Homo sapiens_hsa030220.50661229
62Protein export_Homo sapiens_hsa030600.49297783
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47758020
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47219196
65Fatty acid metabolism_Homo sapiens_hsa012120.46985871
66Huntingtons disease_Homo sapiens_hsa050160.45564924
67Ribosome_Homo sapiens_hsa030100.45240006
68Folate biosynthesis_Homo sapiens_hsa007900.44896439
69Carbon metabolism_Homo sapiens_hsa012000.44094761
70Steroid biosynthesis_Homo sapiens_hsa001000.42161999
71Serotonergic synapse_Homo sapiens_hsa047260.41775278
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39261719
73Phototransduction_Homo sapiens_hsa047440.38134423
74Ether lipid metabolism_Homo sapiens_hsa005650.37393287
75Alzheimers disease_Homo sapiens_hsa050100.35920239
76Olfactory transduction_Homo sapiens_hsa047400.35912606
77Homologous recombination_Homo sapiens_hsa034400.34293496
78Fatty acid elongation_Homo sapiens_hsa000620.31364865
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29063216
80Vitamin digestion and absorption_Homo sapiens_hsa049770.28946104
81Circadian rhythm_Homo sapiens_hsa047100.28270479
82Glycerolipid metabolism_Homo sapiens_hsa005610.26899282
83Cardiac muscle contraction_Homo sapiens_hsa042600.26790796
84Cocaine addiction_Homo sapiens_hsa050300.25064873
85Primary immunodeficiency_Homo sapiens_hsa053400.24640772
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22053252
87Lysine degradation_Homo sapiens_hsa003100.21059848
88Prion diseases_Homo sapiens_hsa050200.20940066
89GABAergic synapse_Homo sapiens_hsa047270.20338548
90Proteasome_Homo sapiens_hsa030500.19738988
91RNA polymerase_Homo sapiens_hsa030200.18145464
92Mineral absorption_Homo sapiens_hsa049780.16794123
93Taste transduction_Homo sapiens_hsa047420.16547271
94Glutamatergic synapse_Homo sapiens_hsa047240.16339006
95Systemic lupus erythematosus_Homo sapiens_hsa053220.16024069
96Morphine addiction_Homo sapiens_hsa050320.15509008
97Insulin secretion_Homo sapiens_hsa049110.14790713
98Amphetamine addiction_Homo sapiens_hsa050310.13628311
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13428813
100Fanconi anemia pathway_Homo sapiens_hsa034600.13389426

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