PLEKHS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.52705129
2left/right pattern formation (GO:0060972)8.31711375
3branching involved in prostate gland morphogenesis (GO:0060442)8.29775112
4regulation of cilium movement (GO:0003352)7.66656577
5primary alcohol catabolic process (GO:0034310)7.41489588
6left/right axis specification (GO:0070986)6.75473706
7ethanol metabolic process (GO:0006067)6.33208642
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.20610301
9ventricular system development (GO:0021591)6.18759426
10interferon-gamma secretion (GO:0072643)6.04890179
11hypotonic response (GO:0006971)5.97993641
12microtubule bundle formation (GO:0001578)5.84498021
13diterpenoid biosynthetic process (GO:0016102)5.81031707
14regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.68548494
15intraciliary transport (GO:0042073)5.48023702
16COPI coating of Golgi vesicle (GO:0048205)5.45542746
17Golgi transport vesicle coating (GO:0048200)5.45542746
18epithelial cell differentiation involved in prostate gland development (GO:0060742)5.42721036
19cilium organization (GO:0044782)5.27073570
20prostate gland epithelium morphogenesis (GO:0060740)5.16621295
21cilium assembly (GO:0042384)5.09597697
22fucose catabolic process (GO:0019317)5.07923192
23L-fucose metabolic process (GO:0042354)5.07923192
24L-fucose catabolic process (GO:0042355)5.07923192
25artery development (GO:0060840)5.07669991
26hemidesmosome assembly (GO:0031581)4.95777180
27hepatocyte apoptotic process (GO:0097284)4.91173385
28intestinal epithelial cell development (GO:0060576)4.84899386
29epithelial cell maturation (GO:0002070)4.79136898
30ethanol oxidation (GO:0006069)4.74668424
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.69173091
32one-carbon compound transport (GO:0019755)4.66877982
33regulation of interleukin-5 production (GO:0032674)4.65808710
34response to xenobiotic stimulus (GO:0009410)4.62519817
35mannose metabolic process (GO:0006013)4.61319735
36tolerance induction (GO:0002507)4.44983011
37regulation of microtubule-based movement (GO:0060632)4.37107846
38N-glycan processing (GO:0006491)4.31109935
39regulation of interleukin-13 production (GO:0032656)4.26581351
40centriole assembly (GO:0098534)4.25826751
41microtubule-based movement (GO:0007018)4.21964140
42protein localization to cilium (GO:0061512)4.18481970
43negative regulation of T cell differentiation in thymus (GO:0033085)4.17987372
44negative regulation of humoral immune response (GO:0002921)4.16084317
45mesodermal cell differentiation (GO:0048333)4.14497133
46ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.14102454
47establishment of apical/basal cell polarity (GO:0035089)4.10798389
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.10345049
49mitotic cell cycle arrest (GO:0071850)4.09162938
50lung lobe morphogenesis (GO:0060463)4.08480845
51sperm capacitation (GO:0048240)4.06768452
52cellular component assembly involved in morphogenesis (GO:0010927)4.05374222
53glomerular epithelial cell development (GO:0072310)4.02269016
54negative regulation of B cell mediated immunity (GO:0002713)4.01488977
55negative regulation of immunoglobulin mediated immune response (GO:0002890)4.01488977
56activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.00295580
57fucose metabolic process (GO:0006004)3.97962992
58terpenoid biosynthetic process (GO:0016114)3.96163893
59cell adhesion mediated by integrin (GO:0033627)3.95669596
60retinoic acid metabolic process (GO:0042573)3.89553571
61calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.87333994
62cell projection assembly (GO:0030031)3.84707220
63response to testosterone (GO:0033574)3.83210008
64O-glycan processing (GO:0016266)3.82370394
65positive regulation of nuclease activity (GO:0032075)3.81235709
66protein retention in ER lumen (GO:0006621)3.79689923
67hormone catabolic process (GO:0042447)3.77602117
68exogenous drug catabolic process (GO:0042738)3.74962611
69regulation of receptor binding (GO:1900120)3.70832485
70lateral ventricle development (GO:0021670)3.70520582
71positive regulation of tolerance induction (GO:0002645)3.69045836
72regulation of germinal center formation (GO:0002634)3.68337463
73cilium morphogenesis (GO:0060271)3.66181437
74lung epithelium development (GO:0060428)3.65808546
75apoptotic cell clearance (GO:0043277)3.64698784
76positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.61236578
77positive regulation of natural killer cell differentiation (GO:0032825)3.60115268
78endoplasmic reticulum unfolded protein response (GO:0030968)3.56749836
79vitamin transmembrane transport (GO:0035461)3.52906934
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.49958493
81establishment of monopolar cell polarity (GO:0061162)3.49958493
82cytoskeletal anchoring at plasma membrane (GO:0007016)3.48321460
83primary alcohol metabolic process (GO:0034308)3.47057001
84regulation of nuclease activity (GO:0032069)3.45558835
85cellular response to unfolded protein (GO:0034620)3.45296797
86positive regulation of protein localization to plasma membrane (GO:1903078)3.44346132
87galactose catabolic process (GO:0019388)3.43947108
88angiotensin maturation (GO:0002003)3.43154012
89UDP-N-acetylglucosamine metabolic process (GO:0006047)3.42809660
90cytoplasmic microtubule organization (GO:0031122)3.41325917
91positive regulation of steroid hormone secretion (GO:2000833)3.37146939
92multicellular organismal water homeostasis (GO:0050891)3.35549353
93regulation of natural killer cell differentiation (GO:0032823)3.35454551
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30577684
95phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.30254158
96regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.28171672
97ER-nucleus signaling pathway (GO:0006984)3.26031682
98renal system development (GO:0072001)3.25960501
99retinol metabolic process (GO:0042572)3.23807969
100skin morphogenesis (GO:0043589)3.20881389
101valine metabolic process (GO:0006573)3.20236984
102nucleoside diphosphate phosphorylation (GO:0006165)3.19479110
103response to endoplasmic reticulum stress (GO:0034976)3.19131202
104positive regulation of growth hormone secretion (GO:0060124)3.18721553
105establishment of planar polarity (GO:0001736)3.15017439
106establishment of tissue polarity (GO:0007164)3.15017439
107intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.15004567
108drug catabolic process (GO:0042737)3.13424710
109cellular response to topologically incorrect protein (GO:0035967)3.13373959
110L-serine transport (GO:0015825)3.10428173
111branching involved in mammary gland duct morphogenesis (GO:0060444)3.09901627
112negative regulation of inclusion body assembly (GO:0090084)3.08349714
113mammary gland development (GO:0030879)3.07975450
114positive regulation of catenin import into nucleus (GO:0035413)3.07533562
115carnitine metabolic process (GO:0009437)3.07426722
116embryonic foregut morphogenesis (GO:0048617)3.06512905
117lens fiber cell development (GO:0070307)3.05839495
118glutathione derivative biosynthetic process (GO:1901687)3.04022797
119glutathione derivative metabolic process (GO:1901685)3.04022797
120renal filtration (GO:0097205)3.02937915
121positive regulation of smoothened signaling pathway (GO:0045880)3.02729795
122tight junction assembly (GO:0070830)3.02436505
123axonemal dynein complex assembly (GO:0070286)20.1977157
124lung secretory cell differentiation (GO:0061140)2.95055790
125hydrogen peroxide biosynthetic process (GO:0050665)2.93716345
126negative regulation of cell fate specification (GO:0009996)2.93478171
127regulation of water loss via skin (GO:0033561)2.92282468
128negative regulation of cell fate commitment (GO:0010454)2.91358911
129beta-amyloid metabolic process (GO:0050435)2.90394355
130excretion (GO:0007588)2.87780514
131oligosaccharide biosynthetic process (GO:0009312)2.85842300
132positive regulation of actin filament depolymerization (GO:0030836)2.85538992
133regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.83947137
134glial cell proliferation (GO:0014009)2.83930325
135water homeostasis (GO:0030104)2.82519132
136lung-associated mesenchyme development (GO:0060484)2.82038178
137cell-substrate junction assembly (GO:0007044)2.81553454
138embryonic skeletal joint morphogenesis (GO:0060272)2.80349176
139keratinocyte differentiation (GO:0030216)2.79787605
140regulation of tolerance induction (GO:0002643)2.79273976
141pyrimidine-containing compound transmembrane transport (GO:0072531)2.79170237
142COPII vesicle coating (GO:0048208)2.78556485
143positive regulation of glycoprotein metabolic process (GO:1903020)2.78386115
144growth hormone receptor signaling pathway (GO:0060396)2.78078991
145sodium ion homeostasis (GO:0055078)2.77509652
146activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.75063855
147epithelial cell-cell adhesion (GO:0090136)2.74875454
148bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74342669
149serine transport (GO:0032329)2.73282048
150phosphatidylcholine biosynthetic process (GO:0006656)2.73081204
151iron ion import (GO:0097286)2.72402778
152glutathione biosynthetic process (GO:0006750)2.71866664
153carnitine transmembrane transport (GO:1902603)2.71664525
154hexose catabolic process (GO:0019320)2.71428653
155microtubule polymerization or depolymerization (GO:0031109)2.71282058
156positive regulation of glycoprotein biosynthetic process (GO:0010560)2.70917789
157vesicle coating (GO:0006901)2.70586899
158apical protein localization (GO:0045176)2.70402281
159protein O-linked glycosylation (GO:0006493)2.69621777
160microtubule depolymerization (GO:0007019)2.68379715
161respiratory tube development (GO:0030323)2.67000707
162organ formation (GO:0048645)2.66180326
163phosphatidylserine metabolic process (GO:0006658)2.65821999
164ear development (GO:0043583)2.64390568
165response to unfolded protein (GO:0006986)2.63506854
166hippo signaling (GO:0035329)2.62670312
167regulation of growth hormone secretion (GO:0060123)2.62625241
168regulation of apoptotic cell clearance (GO:2000425)2.62083838
169embryonic forelimb morphogenesis (GO:0035115)2.61952940
170regulation of alkaline phosphatase activity (GO:0010692)2.60240592
171positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.59691937
172reactive oxygen species biosynthetic process (GO:1903409)2.59237810
173protein N-linked glycosylation via asparagine (GO:0018279)2.58655681
174mammary gland alveolus development (GO:0060749)2.58571318
175retinal rod cell development (GO:0046548)2.58147491
176quaternary ammonium group transport (GO:0015697)2.57993698
177carnitine transport (GO:0015879)2.57271253
178amino-acid betaine transport (GO:0015838)2.57271253
179progesterone metabolic process (GO:0042448)2.56539004
180nonribosomal peptide biosynthetic process (GO:0019184)2.53159345
181regulation of autophagic vacuole assembly (GO:2000785)2.52453016
182regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50068340
183determination of left/right symmetry (GO:0007368)2.49464503
184epoxygenase P450 pathway (GO:0019373)2.49331787
185CDP-diacylglycerol biosynthetic process (GO:0016024)2.48403201
186dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48317311
187regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.46799277
188phenol-containing compound catabolic process (GO:0019336)2.46204971
189hydrogen peroxide catabolic process (GO:0042744)2.43088849
190glutathione metabolic process (GO:0006749)2.43051483
191cilium or flagellum-dependent cell motility (GO:0001539)17.8233771
192cilium movement (GO:0003341)14.9120919
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.8559440
194motile cilium assembly (GO:0044458)13.8182480
195epithelial cilium movement (GO:0003351)12.4032528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.95954473
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95444004
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85701955
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.30695678
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.27104513
6DROSHA_22980978_ChIP-Seq_HELA_Human3.19882282
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.11759842
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05686173
9ZNF263_19887448_ChIP-Seq_K562_Human2.80818658
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.77885430
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75205000
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.72831530
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.70640304
14CLOCK_20551151_ChIP-Seq_293T_Human2.67429707
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66910909
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66580165
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58529041
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.39293189
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.38860177
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.36128594
21SOX2_20726797_ChIP-Seq_SW620_Human2.35850891
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.34955321
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.34955321
24ZNF217_24962896_ChIP-Seq_MCF-7_Human2.29902507
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.26670813
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.24407159
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11710638
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10260812
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.02479450
30CDX2_20551321_ChIP-Seq_CACO-2_Human2.00903791
31GATA6_25053715_ChIP-Seq_YYC3_Human1.91153842
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87430502
33GATA4_25053715_ChIP-Seq_YYC3_Human1.86506853
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82327549
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.81200170
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77974730
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.77098509
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.76950740
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.71376657
40GATA1_22025678_ChIP-Seq_K562_Human1.70206978
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.68991148
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.68978246
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67124314
44STAT1_20625510_ChIP-Seq_HELA_Human1.66347067
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61823562
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.60995990
47SMC4_20622854_ChIP-Seq_HELA_Human1.60848572
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58024123
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57308870
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57115307
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54087270
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53500448
53VDR_22108803_ChIP-Seq_LS180_Human1.52816156
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52286282
55TP63_23658742_ChIP-Seq_EP156T_Human1.52091458
56AR_21909140_ChIP-Seq_LNCAP_Human1.51134142
57ATF3_27146783_Chip-Seq_COLON_Human1.50000096
58RACK7_27058665_Chip-Seq_MCF-7_Human1.49308400
59AHR_22903824_ChIP-Seq_MCF-7_Human1.48881104
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.48762611
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.48606424
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47725116
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44634850
64TP63_22573176_ChIP-Seq_HFKS_Human1.42587882
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41585453
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40760995
67CHD1_26751641_Chip-Seq_LNCaP_Human1.33606042
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32505252
69RAD21_21589869_ChIP-Seq_MESCs_Mouse1.32065540
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30462664
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29581281
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.26593180
73CJUN_26792858_Chip-Seq_BT549_Human1.25994146
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25698677
75KLF5_25053715_ChIP-Seq_YYC3_Human1.23875570
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21770923
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20294899
78GATA1_19941826_ChIP-Seq_K562_Human1.18953502
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18610712
80ETV1_20927104_ChIP-Seq_GIST48_Human1.18242816
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15874835
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15862450
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.15287436
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.15281822
85TP53_18474530_ChIP-ChIP_U2OS_Human1.13640617
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13594933
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.12842792
88SMRT_27268052_Chip-Seq_Bcells_Human1.12337247
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.11198442
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10692188
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10018971
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10018971
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09054391
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.08970480
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08305918
96CTCF_27219007_Chip-Seq_Bcells_Human1.07579078
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07388539
98CREB1_26743006_Chip-Seq_LNCaP_Human1.06389767
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.06312761
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06204586
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05847617
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05732656
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05012344
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04954861
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04799649
106PHF8_20622853_ChIP-Seq_HELA_Human1.04083843
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03965759
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02718049
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00996563
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99044537
111RBPJ_21746931_ChIP-Seq_IB4_Human0.98761772
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98025822
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.97423006
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97053256
115LXR_22292898_ChIP-Seq_THP-1_Human0.96980583
116TP53_16413492_ChIP-PET_HCT116_Human0.96751381
117CEBPB_22108803_ChIP-Seq_LS180_Human0.96471866
118P68_20966046_ChIP-Seq_HELA_Human0.96125619
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96053974
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.95738211
121CTCF_20526341_ChIP-Seq_ESCs_Human0.95696816
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.95247254
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94676199
124ELF5_23300383_ChIP-Seq_T47D_Human0.93731119
125GATA2_19941826_ChIP-Seq_K562_Human0.93566005
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93167006
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92473585
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.92069775
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.91771419
130TP53_22127205_ChIP-Seq_IMR90_Human0.91538320
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91326574
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91326574
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91326574
134PHF8_20622854_ChIP-Seq_HELA_Human0.90036164
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.90003888
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.89783915
137P300_27268052_Chip-Seq_Bcells_Human0.89074616
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88248592
139CBX2_22325352_ChIP-Seq_293T-Rex_Human0.87988921
140NFYA_21822215_ChIP-Seq_K562_Human0.87091947
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86616929
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.86417143
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.86417143
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84841124
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84103756
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83834421
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83723119
148NFYB_21822215_ChIP-Seq_K562_Human0.81066157
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80822021
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80567751
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79732734
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78269977
153SOX2_21211035_ChIP-Seq_LN229_Human0.77952859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.96738372
2MP0008875_abnormal_xenobiotic_pharmacok6.20669578
3MP0002653_abnormal_ependyma_morphology5.87676165
4MP0000537_abnormal_urethra_morphology5.02079277
5MP0003300_gastrointestinal_ulcer4.74157797
6MP0002254_reproductive_system_inflammat4.40526330
7MP0002277_abnormal_respiratory_mucosa3.68075565
8MP0005310_abnormal_salivary_gland3.66695757
9MP0002166_altered_tumor_susceptibility3.50922830
10MP0005623_abnormal_meninges_morphology3.02609231
11MP0001984_abnormal_olfaction3.00772637
12MP0004264_abnormal_extraembryonic_tissu2.71546336
13MP0002006_tumorigenesis2.67994245
14MP0004019_abnormal_vitamin_homeostasis2.67908530
15MP0004133_heterotaxia2.39596767
16MP0010678_abnormal_skin_adnexa2.33124541
17MP0008789_abnormal_olfactory_epithelium2.31681385
18MP0005647_abnormal_sex_gland2.12293793
19MP0001873_stomach_inflammation2.03359080
20MP0000678_abnormal_parathyroid_gland2.03027401
21MP0000613_abnormal_salivary_gland2.02520730
22MP0006054_spinal_hemorrhage1.95655316
23MP0010386_abnormal_urinary_bladder1.94015591
24MP0010352_gastrointestinal_tract_polyps1.93454016
25MP0005377_hearing/vestibular/ear_phenot1.91470014
26MP0003878_abnormal_ear_physiology1.91470014
27MP0002168_other_aberrant_phenotype1.86094461
28MP0001765_abnormal_ion_homeostasis1.82840233
29MP0005365_abnormal_bile_salt1.74070464
30MP0003866_abnormal_defecation1.73483850
31MP0002009_preneoplasia1.71574706
32MP0005085_abnormal_gallbladder_physiolo1.70031909
33MP0001881_abnormal_mammary_gland1.65581653
34MP0004272_abnormal_basement_membrane1.65480511
35MP0005083_abnormal_biliary_tract1.64707149
36MP0003566_abnormal_cell_adhesion1.63681726
37MP0002282_abnormal_trachea_morphology1.61986852
38MP0009379_abnormal_foot_pigmentation1.59357021
39MP0000627_abnormal_mammary_gland1.58240640
40MP0010155_abnormal_intestine_physiology1.57760367
41MP0009764_decreased_sensitivity_to1.55913833
42MP0000462_abnormal_digestive_system1.53078634
43MP0002295_abnormal_pulmonary_circulatio1.52063028
44MP0004782_abnormal_surfactant_physiolog1.51570018
45MP0001756_abnormal_urination1.49473010
46MP0005023_abnormal_wound_healing1.47080083
47MP0002796_impaired_skin_barrier1.46088131
48MP0002876_abnormal_thyroid_physiology1.45812731
49MP0003705_abnormal_hypodermis_morpholog1.45717268
50MP0002249_abnormal_larynx_morphology1.45499708
51MP0000566_synostosis1.43302775
52MP0001346_abnormal_lacrimal_gland1.41298419
53MP0004043_abnormal_pH_regulation1.41107357
54MP0003453_abnormal_keratinocyte_physiol1.39525658
55MP0003045_fibrosis1.39083838
56MP0009384_cardiac_valve_regurgitation1.37633189
57MP0000538_abnormal_urinary_bladder1.36267504
58MP0001849_ear_inflammation1.34675128
59MP0005360_urolithiasis1.34212183
60MP0005395_other_phenotype1.33974680
61MP0005166_decreased_susceptibility_to1.32966043
62MP0002160_abnormal_reproductive_system1.29098366
63MP0005499_abnormal_olfactory_system1.27689955
64MP0005394_taste/olfaction_phenotype1.27689955
65MP0009780_abnormal_chondrocyte_physiolo1.26747330
66MP0001666_abnormal_nutrient_absorption1.26061171
67MP0000534_abnormal_ureter_morphology1.25568054
68MP0005165_increased_susceptibility_to1.24699425
69MP0005220_abnormal_exocrine_pancreas1.19360098
70MP0000681_abnormal_thyroid_gland1.19212615
71MP0009643_abnormal_urine_homeostasis1.17260651
72MP0005275_abnormal_skin_tensile1.17176181
73MP0005636_abnormal_mineral_homeostasis1.13835721
74MP0003936_abnormal_reproductive_system1.13562257
75MP0000465_gastrointestinal_hemorrhage1.12845265
76MP0001216_abnormal_epidermal_layer1.10906924
77MP0000477_abnormal_intestine_morphology1.09570696
78MP0005248_abnormal_Harderian_gland1.08167147
79MP0003303_peritoneal_inflammation1.07287117
80MP0005409_darkened_coat_color1.07021144
81MP0005076_abnormal_cell_differentiation1.05607335
82MP0002060_abnormal_skin_morphology1.04806506
83MP0002098_abnormal_vibrissa_morphology1.04646431
84MP0004947_skin_inflammation1.03989102
85MP0003638_abnormal_response/metabolism_1.02887784
86MP0002136_abnormal_kidney_physiology1.01649025
87MP0000767_abnormal_smooth_muscle1.00459338
88MP0005187_abnormal_penis_morphology0.99582284
89MP0002896_abnormal_bone_mineralization0.98654664
90MP0003656_abnormal_erythrocyte_physiolo0.97752209
91MP0000383_abnormal_hair_follicle0.94603555
92MP0005381_digestive/alimentary_phenotyp0.94409379
93MP0001664_abnormal_digestion0.93817214
94MP0001485_abnormal_pinna_reflex0.93719982
95MP0005501_abnormal_skin_physiology0.92803591
96MP0005367_renal/urinary_system_phenotyp0.91043487
97MP0000516_abnormal_urinary_system0.91043487
98MP0005408_hypopigmentation0.90572981
99MP0003183_abnormal_peptide_metabolism0.88684999
100MP0009053_abnormal_anal_canal0.86805287
101MP0009765_abnormal_xenobiotic_induced0.86586788
102MP0004883_abnormal_blood_vessel0.85268523
103MP0001663_abnormal_digestive_system0.84803745
104MP0003091_abnormal_cell_migration0.84513148
105MP0000343_altered_response_to0.83129057
106MP0001944_abnormal_pancreas_morphology0.82095977
107MP0005164_abnormal_response_to0.81118471
108MP0000470_abnormal_stomach_morphology0.80029056
109MP0000377_abnormal_hair_follicle0.79817863
110MP0002135_abnormal_kidney_morphology0.79583462
111MP0005058_abnormal_lysosome_morphology0.79442692
112MP0000762_abnormal_tongue_morphology0.79242050
113MP0003315_abnormal_perineum_morphology0.79099440
114MP0000490_abnormal_crypts_of0.78563425
115MP0005503_abnormal_tendon_morphology0.77238885
116MP0003941_abnormal_skin_development0.76866164
117MP0002928_abnormal_bile_duct0.75855745
118MP0001790_abnormal_immune_system0.74680118
119MP0005387_immune_system_phenotype0.74680118
120MP0002139_abnormal_hepatobiliary_system0.74287142
121MP0005084_abnormal_gallbladder_morpholo0.72951609
122MP0000467_abnormal_esophagus_morphology0.70607244
123MP0005389_reproductive_system_phenotype0.70491707
124MP0001502_abnormal_circadian_rhythm0.70255041
125MP0000604_amyloidosis0.70085939
126MP0010771_integument_phenotype0.69707352
127MP0002111_abnormal_tail_morphology0.68613238
128MP0003115_abnormal_respiratory_system0.68406457
129MP0002405_respiratory_system_inflammati0.68215629
130MP0003937_abnormal_limbs/digits/tail_de0.66784001
131MP0004858_abnormal_nervous_system0.66625810
132MP0002132_abnormal_respiratory_system0.66215707
133MP0000858_altered_metastatic_potential0.65786650
134MP0002734_abnormal_mechanical_nocicepti0.65547453
135MP0008438_abnormal_cutaneous_collagen0.64635464
136MP0002233_abnormal_nose_morphology0.64628674
137MP0009278_abnormal_bone_marrow0.64032145
138MP0004808_abnormal_hematopoietic_stem0.60646752
139MP0002909_abnormal_adrenal_gland0.60100401
140MP0003191_abnormal_cellular_cholesterol0.60025786
141MP0010329_abnormal_lipoprotein_level0.59527606
142MP0003075_altered_response_to0.58805400
143MP0001533_abnormal_skeleton_physiology0.58766406
144MP0000249_abnormal_blood_vessel0.57485523
145MP0001958_emphysema0.55912136
146MP0006082_CNS_inflammation0.55388427
147MP0003718_maternal_effect0.54365498
148MP0001270_distended_abdomen0.52622875
149MP0001299_abnormal_eye_distance/0.52492715
150MP0003119_abnormal_digestive_system0.52075234
151MP0003436_decreased_susceptibility_to0.50140207
152MP0005167_abnormal_blood-brain_barrier0.49403656
153MP0002133_abnormal_respiratory_system0.48188236
154MP0005388_respiratory_system_phenotype0.48188236
155MP0009763_increased_sensitivity_to0.46839887
156MP0008872_abnormal_physiological_respon0.46825150
157MP0001727_abnormal_embryo_implantation0.46382173

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.97859856
2Chronic bronchitis (HP:0004469)7.81406128
3Bronchiectasis (HP:0002110)7.41870050
4Nasal polyposis (HP:0100582)6.81169896
5Abnormality of the nasal mucosa (HP:0000433)5.76758421
6Abnormality of cochlea (HP:0000375)5.56488699
7Onycholysis (HP:0001806)5.46907717
8Aortic aneurysm (HP:0004942)4.82037005
9Bronchitis (HP:0012387)4.58338593
10Recurrent sinusitis (HP:0011108)4.50636541
11Chronic sinusitis (HP:0011109)4.16995844
12Infertility (HP:0000789)4.11246431
13Milia (HP:0001056)3.98602327
14Recurrent otitis media (HP:0000403)3.95453560
15Micronodular cirrhosis (HP:0001413)3.95440961
16Rectal prolapse (HP:0002035)3.93198435
17Right ventricular cardiomyopathy (HP:0011663)3.83318802
18Atrophic scars (HP:0001075)3.82502339
19Radial bowing (HP:0002986)3.78701546
20Morphological abnormality of the inner ear (HP:0011390)3.61889699
21Hyperactive renin-angiotensin system (HP:0000841)3.44162140
22Occipital encephalocele (HP:0002085)3.36386264
23Aortic dissection (HP:0002647)3.36094881
24Pili torti (HP:0003777)3.26250484
25Hypoplasia of the uterus (HP:0000013)3.23099835
26Aplastic anemia (HP:0001915)3.20490367
27Chronic otitis media (HP:0000389)3.19447209
28Fibular aplasia (HP:0002990)3.13770370
29Ulnar bowing (HP:0003031)3.12414059
30Focal segmental glomerulosclerosis (HP:0000097)3.10454658
31Pancreatic fibrosis (HP:0100732)3.10411249
32Interstitial pulmonary disease (HP:0006530)3.10342662
33True hermaphroditism (HP:0010459)3.08662308
34Bowed forearm bones (HP:0003956)3.02670492
35Bowing of the arm (HP:0006488)3.02670492
36Atelectasis (HP:0100750)2.97775255
37Pustule (HP:0200039)2.94966417
38Fragile nails (HP:0001808)2.83905180
39Subacute progressive viral hepatitis (HP:0006572)2.83206842
40Esophageal varix (HP:0002040)2.76620852
41Vacuolated lymphocytes (HP:0001922)2.71725148
42Cystic liver disease (HP:0006706)2.69989433
43Aneurysm (HP:0002617)2.67375615
44Glomerulosclerosis (HP:0000096)2.64813891
45Aplasia/hypoplasia of the uterus (HP:0008684)2.61279520
46Hypoplastic nipples (HP:0002557)2.59109237
47Cervical subluxation (HP:0003308)2.56095224
48Cone-rod dystrophy (HP:0000548)2.55606309
49Curly hair (HP:0002212)2.52240930
50Abnormality of midbrain morphology (HP:0002418)2.52219478
51Molar tooth sign on MRI (HP:0002419)2.52219478
52Pancreatic cysts (HP:0001737)2.51096251
53Potter facies (HP:0002009)2.46863705
54Facial shape deformation (HP:0011334)2.46863705
55Hypoplastic labia majora (HP:0000059)2.46090206
56Nephronophthisis (HP:0000090)2.45611462
57Plantar hyperkeratosis (HP:0007556)2.43482517
58Arterial tortuosity (HP:0005116)2.42276891
59Bronchomalacia (HP:0002780)2.41804225
60Aplasia involving bones of the extremities (HP:0009825)2.39863646
61Aplasia involving bones of the upper limbs (HP:0009823)2.39863646
62Aplasia of the phalanges of the hand (HP:0009802)2.39863646
63Biliary tract neoplasm (HP:0100574)2.36359192
64Recurrent bronchitis (HP:0002837)2.36229662
65Abdominal distention (HP:0003270)2.36069971
66Chronic hepatic failure (HP:0100626)2.30881048
67Hematochezia (HP:0002573)2.30397438
68Abnormality of the 2nd finger (HP:0004100)2.29799385
69Decreased circulating renin level (HP:0003351)2.27614011
70Nail dystrophy (HP:0008404)2.26108709
71Abnormal hair laboratory examination (HP:0003328)2.21420086
72Abnormality of the labia majora (HP:0012881)2.21057541
73Vascular tortuosity (HP:0004948)2.20104111
74Ankyloglossia (HP:0010296)2.19387822
75Abnormality of the intrinsic pathway (HP:0010989)2.18848141
76Tubulointerstitial nephritis (HP:0001970)2.18166986
77Abnormality of oral frenula (HP:0000190)2.18065208
78Postaxial foot polydactyly (HP:0001830)2.17673468
79Bell-shaped thorax (HP:0001591)2.15653942
80Osteolytic defects of the hand bones (HP:0009699)2.14981878
81Osteolytic defects of the phalanges of the hand (HP:0009771)2.14981878
82Shawl scrotum (HP:0000049)2.14423571
83Short nail (HP:0001799)2.13846248
84Hypoplasia of dental enamel (HP:0006297)2.13337596
85Cerebral aneurysm (HP:0004944)2.12659608
86Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.11977593
87Thoracolumbar scoliosis (HP:0002944)2.11242843
88Ureteral stenosis (HP:0000071)2.10136534
89Ankle contracture (HP:0006466)2.09144863
90Exocrine pancreatic insufficiency (HP:0001738)2.08803910
91Abnormality of proline metabolism (HP:0010907)2.04804742
92Hydroxyprolinuria (HP:0003080)2.04804742
93Abnormality of the distal phalanges of the toes (HP:0010182)2.03518649
94Short humerus (HP:0005792)2.02271957
95Hydroureter (HP:0000072)2.00501025
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3085708
97Abnormal respiratory epithelium morphology (HP:0012253)11.0979468
98Abnormal respiratory motile cilium morphology (HP:0005938)11.0979468
99Dynein arm defect of respiratory motile cilia (HP:0012255)10.9513024
100Absent/shortened dynein arms (HP:0200106)10.9513024
101Abnormal respiratory motile cilium physiology (HP:0012261)10.8051298
102Abnormal ciliary motility (HP:0012262)10.6891506
103Ureteral obstruction (HP:0006000)1.99773323
104Alopecia of scalp (HP:0002293)1.98793099
105Abnormality of secondary sexual hair (HP:0009888)1.98678742
106Abnormality of the axillary hair (HP:0100134)1.98678742
107Subcapsular cataract (HP:0000523)1.98631076
108Congenital, generalized hypertrichosis (HP:0004540)1.97365629
109Abnormality of the renal medulla (HP:0100957)1.95598439
110Sparse lateral eyebrow (HP:0005338)1.95366243
111Aplasia/Hypoplasia of the clavicles (HP:0006710)1.95320069
112Hand muscle atrophy (HP:0009130)1.94483006
113Abnormal foot bone ossification (HP:0010675)1.94444422
114Absent frontal sinuses (HP:0002688)1.94335469
115Short hallux (HP:0010109)1.92326589
116Renal salt wasting (HP:0000127)1.92299826
117Abnormality of the proximal phalanges of the hand (HP:0009834)1.92227756
118Back pain (HP:0003418)1.92170487
119Thrombocytosis (HP:0001894)1.90568104
120Tarsal synostosis (HP:0008368)1.90068479
121Hypoplasia of the pons (HP:0012110)1.89991496
122Germ cell neoplasia (HP:0100728)1.88809712
123Congenital hepatic fibrosis (HP:0002612)1.88607670
124Achilles tendon contracture (HP:0001771)1.87398280
125Fragile skin (HP:0001030)1.82780811
126Hyperkalemia (HP:0002153)1.82270964
127Abnormality of the odontoid process (HP:0003310)1.78783899
128Abnormality of the gastric mucosa (HP:0004295)1.77110634
129Male infertility (HP:0003251)1.76741762
130Aplasia/Hypoplasia of the ulna (HP:0006495)1.76104875
131Malignant gastrointestinal tract tumors (HP:0006749)1.76081828
132Gastrointestinal carcinoma (HP:0002672)1.76081828
133Dysostosis multiplex (HP:0000943)1.75420048
134Mucopolysacchariduria (HP:0008155)1.75353665
135Urinary glycosaminoglycan excretion (HP:0003541)1.75353665
136Aortic regurgitation (HP:0001659)1.75045714
137Polar cataract (HP:0010696)1.74982910
138Spastic diplegia (HP:0001264)1.73539409
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.73137873
140Anencephaly (HP:0002323)1.70922151
141Male pseudohermaphroditism (HP:0000037)1.70654710
142Abnormality of renin-angiotensin system (HP:0000847)1.69954846
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.69660464
144Hyperaldosteronism (HP:0000859)1.69526321
145Asplenia (HP:0001746)1.63790161
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.63423762
147Tubular atrophy (HP:0000092)1.62513659
148Nephropathy (HP:0000112)1.60128996
149Medial flaring of the eyebrow (HP:0010747)1.58900853
150Furrowed tongue (HP:0000221)1.56346626
151Abnormality of chloride homeostasis (HP:0011422)1.54218838
152Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.47629764
153Congenital primary aphakia (HP:0007707)1.47047703
154Oculomotor apraxia (HP:0000657)1.42362694
155Gait imbalance (HP:0002141)1.42306156
156Sclerocornea (HP:0000647)1.42288962
157Malnutrition (HP:0004395)1.37164450
158Lip pit (HP:0100267)1.37018018
159Abnormality of monocarboxylic acid metabolism (HP:0010996)1.33315987
160Flat acetabular roof (HP:0003180)1.33248214
161Postaxial hand polydactyly (HP:0001162)1.30357675
162Abnormality of the dental root (HP:0006486)1.29284904
163Taurodontia (HP:0000679)1.29284904
164Abnormality of permanent molar morphology (HP:0011071)1.29284904
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.27596496
166Short thorax (HP:0010306)1.26540691
167Nephrogenic diabetes insipidus (HP:0009806)1.24412005
168Hyponatremia (HP:0002902)1.23094519
169Glucose intolerance (HP:0000833)1.20237433
170Abnormality of molar (HP:0011077)1.19519020
171Abnormality of molar morphology (HP:0011070)1.19519020
172Median cleft lip (HP:0000161)1.17804079
173Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.16623346
174Abnormality of the frontal sinuses (HP:0002687)1.15485211
175Hypokalemic alkalosis (HP:0001949)1.15308551
176Abnormality of the dental pulp (HP:0006479)1.15153377
177Decreased central vision (HP:0007663)1.14897989
178Tubulointerstitial abnormality (HP:0001969)1.14570659
179Obstructive sleep apnea (HP:0002870)1.12139368
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.11522511
181Bifid scrotum (HP:0000048)1.10204405
182Popliteal pterygium (HP:0009756)1.09423742
183Stage 5 chronic kidney disease (HP:0003774)1.09246976
184Abnormal glucose tolerance (HP:0001952)1.08090889
185Preaxial hand polydactyly (HP:0001177)1.06701058
186Aplasia of the musculature (HP:0100854)1.05355017
187Short femoral neck (HP:0100864)1.02895914
188Poor coordination (HP:0002370)1.02538347
189Stridor (HP:0010307)1.01992705
190Vascular calcification (HP:0004934)1.00247476
191Fetal akinesia sequence (HP:0001989)0.99487039
192Upper limb amyotrophy (HP:0009129)0.99442515
193Distal upper limb amyotrophy (HP:0007149)0.99442515
194Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.97801101
195Abnormality of glutamine family amino acid metabolism (HP:0010902)0.97309748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.33555000
2MST45.07791852
3AKT34.68608046
4FRK4.14451505
5ERN13.35579680
6LATS12.95615998
7TAOK32.53324914
8MYLK2.33369337
9EEF2K2.20772237
10RPS6KB22.06470850
11MAPK1510.8618615
12STK391.99709006
13LMTK21.99495110
14FER1.97382039
15MAP3K21.91871438
16SMG11.87549148
17TTN1.87291463
18STK241.82416457
19PTK61.82005285
20LRRK21.70891515
21EPHA31.53182134
22TTK1.50653546
23SIK11.50316055
24PTK21.49445835
25MST1R1.47932364
26STK101.46118200
27SCYL21.44546727
28EPHB11.36849224
29MAP2K21.25304557
30DMPK1.23924851
31MAPKAPK31.23449626
32NEK61.22925114
33TESK11.22882833
34NUAK11.21524327
35BCKDK1.16779217
36MET1.14866884
37ACVR1B1.11581016
38MAP3K121.09535820
39TRIB31.06332497
40PAK41.03412520
41EPHB20.96714364
42PDK20.94592431
43PRKCI0.94156474
44RIPK10.88845359
45STK30.87657547
46RIPK40.86527739
47JAK30.86383160
48PDGFRA0.86203075
49PAK20.81247419
50DDR20.80877310
51TGFBR20.79623982
52TRPM70.78026643
53MARK20.77860848
54MAP3K30.76264372
55PKN20.75981927
56OXSR10.70021701
57KSR20.67760784
58CDC42BPA0.67372423
59PIK3CA0.67180544
60PAK30.67143062
61ICK0.66777178
62CAMKK10.66028685
63MAP2K10.62520957
64NLK0.62076513
65BRSK20.61272739
66ROCK20.60620079
67TLK10.59451077
68FGFR30.57774311
69JAK10.57040261
70GRK60.56092346
71FGFR20.56086805
72HIPK20.55472257
73PRKAA20.54093923
74IRAK10.53961219
75BMX0.53580945
76FGFR40.53421622
77ROCK10.53183699
78PIK3CG0.53141554
79PDPK10.52600890
80TYK20.49472936
81NTRK10.49349445
82PRKCD0.47108253
83TAOK10.45566850
84RPS6KA20.45418097
85MAP3K70.44459334
86TGFBR10.43328515
87MAP3K80.42549971
88JAK20.41171147
89MELK0.39761125
90TESK20.38944770
91PNCK0.38518129
92MTOR0.38252405
93PRKCQ0.36873517
94DAPK30.34547006
95SGK10.33856422
96PTK2B0.32884318
97CHUK0.32352773
98CDK60.32139753
99ERBB20.31807999
100LATS20.31490215
101NME10.31211505
102EGFR0.31085736
103LIMK10.30954551
104CSNK1A1L0.30900026
105PDGFRB0.30266390
106STK38L0.29088464
107CAMK2G0.28902155
108BCR0.28683574
109MATK0.28647222
110ILK0.28625130
111RET0.28194261
112CSF1R0.28105124
113TBK10.28027462
114TNK20.27838017
115NEK90.27644297
116ZAP700.27611696
117CDK120.27271476
118PRKCE0.25897522
119MAPKAPK50.25626766
120STK380.25417355
121PRKCA0.25347778
122INSR0.24195800
123MAP3K140.23807897
124SRC0.23792530
125IKBKE0.23783297
126ERBB30.22847995
127CAMK2B0.22393388
128ABL10.22238389
129GRK10.22199580
130PRKG20.21854234
131FYN0.21301235
132PRKCZ0.20673355
133CSK0.20594624
134DYRK1B0.19836370
135RPS6KC10.19317872
136RPS6KL10.19317872
137AKT20.18850305
138PAK10.18786956
139INSRR0.18512125
140PRKD20.16996062
141PDK10.16420358
142PRKD10.15290297
143PRKACA0.15056844
144YES10.13161317
145ADRBK10.12318375
146IGF1R0.12001075

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.78638732
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.30437447
3Phenylalanine metabolism_Homo sapiens_hsa003604.25905522
4Chemical carcinogenesis_Homo sapiens_hsa052044.00229325
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.86707369
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.28435868
7Tyrosine metabolism_Homo sapiens_hsa003503.11092348
8Cyanoamino acid metabolism_Homo sapiens_hsa004603.07915849
9Caffeine metabolism_Homo sapiens_hsa002322.78354451
10Small cell lung cancer_Homo sapiens_hsa052222.51387796
11ECM-receptor interaction_Homo sapiens_hsa045122.43119126
12beta-Alanine metabolism_Homo sapiens_hsa004102.41707206
13Glutathione metabolism_Homo sapiens_hsa004802.32135897
14Adherens junction_Homo sapiens_hsa045202.30397543
15Tight junction_Homo sapiens_hsa045302.25524113
16Retinol metabolism_Homo sapiens_hsa008302.22141753
17Linoleic acid metabolism_Homo sapiens_hsa005912.21924612
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20925138
19Sulfur metabolism_Homo sapiens_hsa009202.12585528
20Leukocyte transendothelial migration_Homo sapiens_hsa046702.03503627
21Bladder cancer_Homo sapiens_hsa052192.00810407
22Focal adhesion_Homo sapiens_hsa045101.95912844
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84380616
24N-Glycan biosynthesis_Homo sapiens_hsa005101.82685664
25Protein export_Homo sapiens_hsa030601.80784503
26Huntingtons disease_Homo sapiens_hsa050161.75584683
27Renin-angiotensin system_Homo sapiens_hsa046141.72333661
28Amoebiasis_Homo sapiens_hsa051461.71152953
29Proteoglycans in cancer_Homo sapiens_hsa052051.65271769
30Vibrio cholerae infection_Homo sapiens_hsa051101.60455375
31Vitamin digestion and absorption_Homo sapiens_hsa049771.59481391
32Sphingolipid metabolism_Homo sapiens_hsa006001.59371191
33Endometrial cancer_Homo sapiens_hsa052131.54849995
34Hippo signaling pathway_Homo sapiens_hsa043901.54334283
35ABC transporters_Homo sapiens_hsa020101.49908319
36Prostate cancer_Homo sapiens_hsa052151.49290788
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.49072466
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48941408
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47101503
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45429438
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39601452
42Arachidonic acid metabolism_Homo sapiens_hsa005901.38337019
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36468324
44Starch and sucrose metabolism_Homo sapiens_hsa005001.35750591
45Toxoplasmosis_Homo sapiens_hsa051451.35482550
46Hepatitis C_Homo sapiens_hsa051601.35296632
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33157250
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33048510
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28227172
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27269049
51Fatty acid degradation_Homo sapiens_hsa000711.27160747
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26030892
53Chronic myeloid leukemia_Homo sapiens_hsa052201.25946820
54Pancreatic cancer_Homo sapiens_hsa052121.18341367
55Other glycan degradation_Homo sapiens_hsa005111.16521688
56Hematopoietic cell lineage_Homo sapiens_hsa046401.12786503
57Thyroid cancer_Homo sapiens_hsa052161.07743396
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05654411
59Thyroid hormone synthesis_Homo sapiens_hsa049181.04169597
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.03517371
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02490686
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02171836
63Mineral absorption_Homo sapiens_hsa049781.01241883
64Pathways in cancer_Homo sapiens_hsa052000.99207342
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95756060
66Fat digestion and absorption_Homo sapiens_hsa049750.94518911
67PPAR signaling pathway_Homo sapiens_hsa033200.93371050
68Peroxisome_Homo sapiens_hsa041460.91065754
69Basal cell carcinoma_Homo sapiens_hsa052170.90555729
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89766188
71TGF-beta signaling pathway_Homo sapiens_hsa043500.88928632
72mTOR signaling pathway_Homo sapiens_hsa041500.86979022
73TNF signaling pathway_Homo sapiens_hsa046680.85048485
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84800804
75Salivary secretion_Homo sapiens_hsa049700.83746372
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83418541
77Protein digestion and absorption_Homo sapiens_hsa049740.81514326
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80672886
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.80434969
80Melanoma_Homo sapiens_hsa052180.79378026
81Wnt signaling pathway_Homo sapiens_hsa043100.77506680
82ErbB signaling pathway_Homo sapiens_hsa040120.76804168
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76403444
84Asthma_Homo sapiens_hsa053100.71636683
85Lysosome_Homo sapiens_hsa041420.70159760
86Circadian rhythm_Homo sapiens_hsa047100.69566294
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.68871069
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67407454
89Glycerolipid metabolism_Homo sapiens_hsa005610.65943559
90Prolactin signaling pathway_Homo sapiens_hsa049170.65179173
91Non-small cell lung cancer_Homo sapiens_hsa052230.64278337
92MicroRNAs in cancer_Homo sapiens_hsa052060.63993304
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63745740
94Influenza A_Homo sapiens_hsa051640.63705662
95Insulin resistance_Homo sapiens_hsa049310.63624727
96Salmonella infection_Homo sapiens_hsa051320.63302612
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62877394
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61980036
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.61233236
100Platelet activation_Homo sapiens_hsa046110.59644626
101Inositol phosphate metabolism_Homo sapiens_hsa005620.59602006
102Glioma_Homo sapiens_hsa052140.59519358
103Apoptosis_Homo sapiens_hsa042100.59456461
104VEGF signaling pathway_Homo sapiens_hsa043700.57889261
105Dilated cardiomyopathy_Homo sapiens_hsa054140.57674881
106Antigen processing and presentation_Homo sapiens_hsa046120.57468124
107Notch signaling pathway_Homo sapiens_hsa043300.56965585
108Allograft rejection_Homo sapiens_hsa053300.56535059
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56246436
110Estrogen signaling pathway_Homo sapiens_hsa049150.56038117
111Hedgehog signaling pathway_Homo sapiens_hsa043400.54610503
112Arginine biosynthesis_Homo sapiens_hsa002200.54360904
113Choline metabolism in cancer_Homo sapiens_hsa052310.54066891
114Autoimmune thyroid disease_Homo sapiens_hsa053200.53178291
115Shigellosis_Homo sapiens_hsa051310.52966724
116Legionellosis_Homo sapiens_hsa051340.52897325
117Colorectal cancer_Homo sapiens_hsa052100.52678638
118HIF-1 signaling pathway_Homo sapiens_hsa040660.52412966
119FoxO signaling pathway_Homo sapiens_hsa040680.51589871
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.51349609
121Pertussis_Homo sapiens_hsa051330.51348477
122Endocytosis_Homo sapiens_hsa041440.51244469
123Fructose and mannose metabolism_Homo sapiens_hsa000510.50533054
124Complement and coagulation cascades_Homo sapiens_hsa046100.49510401
125Graft-versus-host disease_Homo sapiens_hsa053320.48480267
126Staphylococcus aureus infection_Homo sapiens_hsa051500.48160085
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45043676
128Pancreatic secretion_Homo sapiens_hsa049720.44941734
129Rap1 signaling pathway_Homo sapiens_hsa040150.44503941
130Type I diabetes mellitus_Homo sapiens_hsa049400.44422946
131Leishmaniasis_Homo sapiens_hsa051400.43116531
132Histidine metabolism_Homo sapiens_hsa003400.42514054
133Acute myeloid leukemia_Homo sapiens_hsa052210.42134675
134Tryptophan metabolism_Homo sapiens_hsa003800.41437656
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41146245
136Renal cell carcinoma_Homo sapiens_hsa052110.40812380
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.40474922
138Melanogenesis_Homo sapiens_hsa049160.39969692
139Arginine and proline metabolism_Homo sapiens_hsa003300.39854053
140Gap junction_Homo sapiens_hsa045400.39563971
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.38909710
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38908774
143Gastric acid secretion_Homo sapiens_hsa049710.38405621
144Taste transduction_Homo sapiens_hsa047420.38029455
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37988454
146Bile secretion_Homo sapiens_hsa049760.36422037
147Viral myocarditis_Homo sapiens_hsa054160.36411400
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30260157
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29056200
150Cocaine addiction_Homo sapiens_hsa050300.27415913
151Ether lipid metabolism_Homo sapiens_hsa005650.21262598
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19951584
153Fatty acid biosynthesis_Homo sapiens_hsa000610.19403345
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18705833
155Metabolic pathways_Homo sapiens_hsa011000.17721304
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.17028344
157Rheumatoid arthritis_Homo sapiens_hsa053230.16210825
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15761620
159Collecting duct acid secretion_Homo sapiens_hsa049660.13472228
160Ovarian steroidogenesis_Homo sapiens_hsa049130.13225329
161Olfactory transduction_Homo sapiens_hsa047400.12898770
162Serotonergic synapse_Homo sapiens_hsa047260.12151828
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.11488207
164cAMP signaling pathway_Homo sapiens_hsa040240.11166237

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