PLEKHO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.37385809
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.37385809
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.37385809
4modulation by symbiont of host immune response (GO:0052553)6.37385809
5positive regulation by symbiont of host defense response (GO:0052509)6.37385809
6modulation by symbiont of host defense response (GO:0052031)6.37385809
7regulation of interferon-beta biosynthetic process (GO:0045357)5.22444394
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.18461968
9macrophage activation involved in immune response (GO:0002281)4.59301793
10response to peptidoglycan (GO:0032494)4.39513648
11detection of other organism (GO:0098543)4.35823564
12neutrophil activation involved in immune response (GO:0002283)4.35387255
13positive regulation of interferon-alpha production (GO:0032727)4.34424953
14positive regulation of gamma-delta T cell activation (GO:0046645)4.33380709
15immunoglobulin mediated immune response (GO:0016064)4.32865803
16antigen processing and presentation of endogenous antigen (GO:0019883)4.29980614
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24995511
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24995511
19response to host immune response (GO:0052572)4.21178874
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.21178874
21regulation of interferon-alpha production (GO:0032647)4.15930353
22regulation of B cell receptor signaling pathway (GO:0050855)4.14758079
23detection of bacterium (GO:0016045)4.05107666
24detection of external biotic stimulus (GO:0098581)3.93553559
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91441804
26response to host (GO:0075136)3.91441804
27response to host defenses (GO:0052200)3.91441804
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.86191741
29negative regulation of erythrocyte differentiation (GO:0045647)3.80158407
30positive regulation of B cell differentiation (GO:0045579)3.67436764
31response to muramyl dipeptide (GO:0032495)3.67082515
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.63229456
33respiratory burst (GO:0045730)3.60927796
34regulation of leukocyte degranulation (GO:0043300)3.60722388
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.53559442
36microglial cell activation (GO:0001774)3.53457201
37detection of biotic stimulus (GO:0009595)3.50812430
38positive regulation of chemokine biosynthetic process (GO:0045080)3.48173391
39positive regulation of antigen processing and presentation (GO:0002579)3.47939607
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.39408066
41positive regulation of mast cell degranulation (GO:0043306)3.39408066
42myeloid cell activation involved in immune response (GO:0002275)3.37573852
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37110139
44amino sugar catabolic process (GO:0046348)3.33220314
45negative regulation of interleukin-12 production (GO:0032695)3.30909514
46pinocytosis (GO:0006907)3.30009933
47macrophage activation (GO:0042116)3.29649474
48cellular response to thyroid hormone stimulus (GO:0097067)3.27123624
49positive regulation of interferon-beta production (GO:0032728)3.26096341
50B cell mediated immunity (GO:0019724)3.20320593
51granulocyte activation (GO:0036230)3.16128295
52regulation of B cell differentiation (GO:0045577)3.15772361
53neutrophil activation (GO:0042119)3.14367144
54leukocyte aggregation (GO:0070486)3.14039329
55positive regulation of leukocyte degranulation (GO:0043302)3.12590352
56glycosphingolipid catabolic process (GO:0046479)3.10336567
57detection of molecule of bacterial origin (GO:0032490)3.07245516
58defense response to protozoan (GO:0042832)3.06964167
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06372228
60regulation of T cell tolerance induction (GO:0002664)3.04558807
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01560844
62regulation of T-helper 2 cell differentiation (GO:0045628)3.00890017
63regulation of antigen processing and presentation (GO:0002577)3.00563974
64cellular extravasation (GO:0045123)3.00280351
65regulation of mast cell degranulation (GO:0043304)3.00110510
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99858063
67I-kappaB phosphorylation (GO:0007252)2.99083621
68myeloid dendritic cell differentiation (GO:0043011)2.97905826
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97667549
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.95896555
71negative regulation of leukocyte mediated immunity (GO:0002704)2.95773589
72production of molecular mediator involved in inflammatory response (GO:0002532)2.95664224
73myeloid dendritic cell activation (GO:0001773)2.94704936
74interferon-gamma-mediated signaling pathway (GO:0060333)2.94623945
75regulation of regulated secretory pathway (GO:1903305)2.93123590
76regulation of gamma-delta T cell activation (GO:0046643)2.92767191
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92491520
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92432418
79NIK/NF-kappaB signaling (GO:0038061)2.92416767
80natural killer cell mediated immunity (GO:0002228)2.91625603
81natural killer cell mediated cytotoxicity (GO:0042267)2.91625603
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91297967
83negative regulation of cell killing (GO:0031342)2.91297967
84response to type I interferon (GO:0034340)2.91241049
85leukocyte migration involved in inflammatory response (GO:0002523)2.90117975
86negative regulation of interleukin-17 production (GO:0032700)2.90021891
87negative regulation of cytokine production involved in immune response (GO:0002719)2.89839576
88regulation of tolerance induction (GO:0002643)2.89214296
89antigen processing and presentation via MHC class Ib (GO:0002475)2.89173278
90cellular response to type I interferon (GO:0071357)2.89053216
91type I interferon signaling pathway (GO:0060337)2.89053216
92regulation of mast cell activation (GO:0033003)2.87121252
93germinal center formation (GO:0002467)2.87041018
94neutrophil mediated immunity (GO:0002446)2.86638343
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.86445191
96B cell receptor signaling pathway (GO:0050853)2.86392790
97N-acetylneuraminate metabolic process (GO:0006054)2.85268111
98regulation of interleukin-8 biosynthetic process (GO:0045414)2.84656609
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84568349
100response to protozoan (GO:0001562)2.84466582
101barbed-end actin filament capping (GO:0051016)2.83565224
102regulation of mast cell activation involved in immune response (GO:0033006)2.82619535
103regulation of mononuclear cell migration (GO:0071675)2.82518762
104positive regulation of mast cell activation (GO:0033005)2.82480131
105negative regulation of mast cell activation (GO:0033004)2.81641202
106leukocyte cell-cell adhesion (GO:0007159)2.81290718
107regulation of macrophage cytokine production (GO:0010935)2.80172092
108regulation of chemokine biosynthetic process (GO:0045073)2.79518491
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78734882
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76182309
111regulation of gamma-delta T cell differentiation (GO:0045586)2.76160079
112glycolipid catabolic process (GO:0019377)2.75836689
113neutrophil chemotaxis (GO:0030593)2.75270785
114myeloid leukocyte activation (GO:0002274)2.75138174
115regulation of cholesterol storage (GO:0010885)2.72539457
116regulation of macrophage chemotaxis (GO:0010758)2.71717868
117dendritic cell differentiation (GO:0097028)2.70665236
118positive regulation of macrophage cytokine production (GO:0060907)2.70600631
119oligosaccharide catabolic process (GO:0009313)2.70345733
120positive regulation of cellular amide metabolic process (GO:0034250)2.70162380
121neutrophil migration (GO:1990266)2.67713889
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64408853
123positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.64039069
124regulation of integrin activation (GO:0033623)2.63626432
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.62943644
126response to interferon-alpha (GO:0035455)2.60701658
127negative regulation of interleukin-6 production (GO:0032715)2.58960812
128positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58667842
129positive regulation of NF-kappaB import into nucleus (GO:0042346)2.56436676
130superoxide anion generation (GO:0042554)2.56355202
131T-helper 1 type immune response (GO:0042088)2.55940081
132negative regulation of phagocytosis (GO:0050765)2.55884006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.43086565
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.20153837
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.89779026
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.77389916
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.70176703
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.64172608
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56520966
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43972636
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36252418
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25771537
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20889867
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.06719406
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86342810
14* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.82808202
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73332047
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72558715
17SCL_19346495_ChIP-Seq_HPC-7_Human2.71712440
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.43834041
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43775990
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41265685
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37238472
22VDR_21846776_ChIP-Seq_THP-1_Human2.33623784
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24590421
24* SPI1_23547873_ChIP-Seq_NB4_Human2.20831068
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16504469
26VDR_24763502_ChIP-Seq_THP-1_Human2.13568192
27MAF_26560356_Chip-Seq_TH1_Human2.06818873
28MYC_22102868_ChIP-Seq_BL_Human2.04956189
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.04149192
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03110256
31MYB_26560356_Chip-Seq_TH2_Human1.97605048
32* SPI1_23127762_ChIP-Seq_K562_Human1.97076689
33RUNX_20019798_ChIP-Seq_JUKART_Human1.87864400
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82019824
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81652482
36* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73606509
37MYB_26560356_Chip-Seq_TH1_Human1.73395737
38TCF7_22412390_ChIP-Seq_EML_Mouse1.72476596
39E2F7_22180533_ChIP-Seq_HELA_Human1.70991253
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67163877
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64894495
42GATA1_22025678_ChIP-Seq_K562_Human1.64472244
43UTX_26944678_Chip-Seq_JUKART_Human1.64420223
44PU_27001747_Chip-Seq_BMDM_Mouse1.62763827
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62081634
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54153074
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52370393
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51201041
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.49151439
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44774892
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44147479
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43345140
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40279949
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39094074
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38379190
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37241902
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36566342
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36327533
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.36034584
60VDR_24787735_ChIP-Seq_THP-1_Human1.35906055
61* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32402667
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31965598
63KDM2B_26808549_Chip-Seq_DND41_Human1.29442702
64TFEB_21752829_ChIP-Seq_HELA_Human1.27690753
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.27265371
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25354243
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22884128
68* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22699787
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22555538
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21891480
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21743392
72GATA3_27048872_Chip-Seq_THYMUS_Human1.21645323
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.19483709
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19011027
75GATA1_19941826_ChIP-Seq_K562_Human1.17342806
76MAF_26560356_Chip-Seq_TH2_Human1.17006101
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16652251
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15319370
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15135005
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14524244
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12161985
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12048281
83* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11913255
84* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11292245
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.09629422
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08154647
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07378494
88KDM2B_26808549_Chip-Seq_K562_Human1.05914269
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03679827
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02482903
91BCL6_27268052_Chip-Seq_Bcells_Human1.01728722
92* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01087885
93GATA2_19941826_ChIP-Seq_K562_Human1.00307739
94RACK7_27058665_Chip-Seq_MCF-7_Human0.99168116
95GATA3_26560356_Chip-Seq_TH2_Human0.98906292
96BCOR_27268052_Chip-Seq_Bcells_Human0.98493935
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98294193
98NCOR1_26117541_ChIP-Seq_K562_Human0.96389868
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.94475757
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94376461
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93762657
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89435456
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87442437
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87353678
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87161124
106LXR_22292898_ChIP-Seq_THP-1_Human0.87033095
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85289163
108SA1_27219007_Chip-Seq_ERYTHROID_Human0.83361840
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82637684
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.82223523
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81607268
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78696614
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78696614
114SPI1_20517297_ChIP-Seq_HL60_Human0.78107169
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.74598891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.96058721
2MP0003303_peritoneal_inflammation3.34949163
3MP0003436_decreased_susceptibility_to3.15146300
4MP0005058_abnormal_lysosome_morphology2.92069122
5MP0002419_abnormal_innate_immunity2.86752107
6MP0009785_altered_susceptibility_to2.82443251
7MP0005000_abnormal_immune_tolerance2.67517626
8MP0006082_CNS_inflammation2.65310765
9MP0000685_abnormal_immune_system2.59505895
10MP0001790_abnormal_immune_system2.57240352
11MP0005387_immune_system_phenotype2.57240352
12MP0002452_abnormal_antigen_presenting2.52155023
13MP0005025_abnormal_response_to2.51183361
14MP0004510_myositis2.46444512
15MP0002148_abnormal_hypersensitivity_rea2.44794651
16MP0001800_abnormal_humoral_immune2.44618559
17MP0009278_abnormal_bone_marrow2.40744081
18MP0005464_abnormal_platelet_physiology2.29674886
19MP0003724_increased_susceptibility_to2.29373527
20MP0002723_abnormal_immune_serum2.27353101
21MP0005671_abnormal_response_to2.24252427
22MP0003172_abnormal_lysosome_physiology2.24098238
23MP0001819_abnormal_immune_cell2.14705823
24MP0002420_abnormal_adaptive_immunity2.14112303
25MP0000569_abnormal_digit_pigmentation2.12764970
26MP0003300_gastrointestinal_ulcer2.09738559
27MP0001853_heart_inflammation2.05386192
28MP0002405_respiratory_system_inflammati2.01252514
29MP0004947_skin_inflammation1.94206818
30MP0001533_abnormal_skeleton_physiology1.93108947
31MP0003191_abnormal_cellular_cholesterol1.86863209
32MP0001545_abnormal_hematopoietic_system1.83857927
33MP0005397_hematopoietic_system_phenotyp1.83857927
34MP0003448_altered_tumor_morphology1.75345227
35MP0002398_abnormal_bone_marrow1.71750113
36MP0000343_altered_response_to1.70313060
37MP0001845_abnormal_inflammatory_respons1.63982764
38MP0009333_abnormal_splenocyte_physiolog1.63776735
39MP0000716_abnormal_immune_system1.63363805
40MP0009840_abnormal_foam_cell1.60804832
41MP0005451_abnormal_body_composition1.58316225
42MP0000689_abnormal_spleen_morphology1.57715920
43MP0010155_abnormal_intestine_physiology1.54156279
44MP0008438_abnormal_cutaneous_collagen1.51971996
45MP0004808_abnormal_hematopoietic_stem1.51845688
46MP0010307_abnormal_tumor_latency1.48389861
47MP0002396_abnormal_hematopoietic_system1.46908838
48MP0003566_abnormal_cell_adhesion1.46203681
49MP0005174_abnormal_tail_pigmentation1.43596379
50MP0000858_altered_metastatic_potential1.43284599
51MP0002722_abnormal_immune_system1.42646041
52MP0003705_abnormal_hypodermis_morpholog1.41253918
53MP0000465_gastrointestinal_hemorrhage1.40612952
54MP0002429_abnormal_blood_cell1.40526568
55MP0003656_abnormal_erythrocyte_physiolo1.40166687
56MP0009764_decreased_sensitivity_to1.39048110
57MP0003075_altered_response_to1.39028236
58MP0008469_abnormal_protein_level1.36908997
59MP0003828_pulmonary_edema1.35975877
60MP0002166_altered_tumor_susceptibility1.34474684
61MP0002998_abnormal_bone_remodeling1.30730092
62MP0005310_abnormal_salivary_gland1.28063239
63MP0010352_gastrointestinal_tract_polyps1.27152472
64MP0002006_tumorigenesis1.25738294
65MP0002933_joint_inflammation1.24158596
66MP0003183_abnormal_peptide_metabolism1.22637564
67MP0001958_emphysema1.22346569
68MP0001851_eye_inflammation1.17945323
69MP0001873_stomach_inflammation1.17754646
70MP0005076_abnormal_cell_differentiation1.16172241
71MP0003279_aneurysm1.13332971
72MP0000604_amyloidosis1.12983978
73MP0002254_reproductive_system_inflammat1.11597435
74MP0000490_abnormal_crypts_of1.09653538
75MP0008004_abnormal_stomach_pH1.08802805
76MP0005257_abnormal_intraocular_pressure1.07641198
77MP0005023_abnormal_wound_healing1.07202776
78MP0003763_abnormal_thymus_physiology1.04268196
79MP0003091_abnormal_cell_migration1.04239411
80MP0003329_amyloid_beta_deposits1.03021348
81MP0005166_decreased_susceptibility_to1.02988594
82MP0005390_skeleton_phenotype1.01493345
83MP0000920_abnormal_myelination0.95386079
84MP0003806_abnormal_nucleotide_metabolis0.95116695
85MP0000767_abnormal_smooth_muscle0.93839181
86MP0003045_fibrosis0.92441225
87MP0000703_abnormal_thymus_morphology0.91151893
88MP0006054_spinal_hemorrhage0.90089928
89MP0000015_abnormal_ear_pigmentation0.89916639
90MP0000249_abnormal_blood_vessel0.87573362
91MP0005164_abnormal_response_to0.87536110
92MP0003690_abnormal_glial_cell0.87244904
93MP0005167_abnormal_blood-brain_barrier0.85400452
94MP0002132_abnormal_respiratory_system0.85194243
95MP0002277_abnormal_respiratory_mucosa0.84020128
96MP0009763_increased_sensitivity_to0.83024839
97MP0000371_diluted_coat_color0.76939069
98MP0001849_ear_inflammation0.76181111
99MP0001542_abnormal_bone_strength0.74203051
100MP0002139_abnormal_hepatobiliary_system0.74201873
101MP0002138_abnormal_hepatobiliary_system0.73040330
102MP0003795_abnormal_bone_structure0.72896954
103MP0003866_abnormal_defecation0.72240174
104MP0004883_abnormal_blood_vessel0.71051577
105MP0003453_abnormal_keratinocyte_physiol0.66963933
106MP0008874_decreased_physiological_sensi0.66565585
107MP0002877_abnormal_melanocyte_morpholog0.65437900
108MP0001879_abnormal_lymphatic_vessel0.64194443
109MP0004381_abnormal_hair_follicle0.62239295
110MP0005165_increased_susceptibility_to0.62037245
111MP0002019_abnormal_tumor_incidence0.61085332
112MP0000733_abnormal_muscle_development0.59189857
113MP0008260_abnormal_autophagy0.58749516
114MP0001915_intracranial_hemorrhage0.57554319
115MP0001663_abnormal_digestive_system0.54941022

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.22726545
2Eczematoid dermatitis (HP:0000976)5.50690005
3Recurrent bacterial skin infections (HP:0005406)5.43442402
4Increased cerebral lipofuscin (HP:0011813)4.97036530
5Elevated erythrocyte sedimentation rate (HP:0003565)4.51861955
6Recurrent gram-negative bacterial infections (HP:0005420)4.41790996
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.37676624
8Myositis (HP:0100614)4.29807353
9Abnormality of macrophages (HP:0004311)4.25372524
10Vacuolated lymphocytes (HP:0001922)4.03173154
11Mediastinal lymphadenopathy (HP:0100721)3.86322375
12Orchitis (HP:0100796)3.76455402
13Systemic lupus erythematosus (HP:0002725)3.60210647
14Autoimmune thrombocytopenia (HP:0001973)3.50972091
15Recurrent skin infections (HP:0001581)3.47059524
16Obstructive lung disease (HP:0006536)3.44702762
17Chronic obstructive pulmonary disease (HP:0006510)3.44702762
18Retrobulbar optic neuritis (HP:0100654)3.37793289
19Optic neuritis (HP:0100653)3.37793289
20Recurrent fungal infections (HP:0002841)3.36383204
21Cellulitis (HP:0100658)3.32939527
22Stomatitis (HP:0010280)3.32679328
23Gingivitis (HP:0000230)3.27169557
24Dysostosis multiplex (HP:0000943)3.18596030
25Abnormality of liposaccharide metabolism (HP:0010968)3.15330461
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.15330461
27Abnormality of glycolipid metabolism (HP:0010969)3.15330461
28Recurrent viral infections (HP:0004429)3.08571472
29Vasculitis (HP:0002633)2.98249309
30Chronic otitis media (HP:0000389)2.92428041
31Amyloidosis (HP:0011034)2.88347938
32Pustule (HP:0200039)2.87048920
33Petechiae (HP:0000967)2.83415360
34Hematochezia (HP:0002573)2.80328560
35Interstitial pulmonary disease (HP:0006530)2.78471398
36Pulmonary infiltrates (HP:0002113)2.73846590
37Mucopolysacchariduria (HP:0008155)2.72190410
38Urinary glycosaminoglycan excretion (HP:0003541)2.72190410
39Loss of speech (HP:0002371)2.71809908
40Periodontitis (HP:0000704)2.69680007
41Mutism (HP:0002300)2.68537204
42Meningitis (HP:0001287)2.65059447
43Colitis (HP:0002583)2.63135914
44Abnormality of polysaccharide metabolism (HP:0011012)2.60839044
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60839044
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60839044
47Gastrointestinal infarctions (HP:0005244)2.59448872
48Urticaria (HP:0001025)2.55911436
49Axonal loss (HP:0003447)2.55580406
50Chronic mucocutaneous candidiasis (HP:0002728)2.55560544
51Recurrent cutaneous fungal infections (HP:0011370)2.55560544
52Myocardial infarction (HP:0001658)2.55342350
53Arterial thrombosis (HP:0004420)2.53941724
54Disinhibition (HP:0000734)2.51900306
55Osteomyelitis (HP:0002754)2.51282422
56Spontaneous hematomas (HP:0007420)2.51244565
57Inflammation of the large intestine (HP:0002037)2.50515424
58Prostate neoplasm (HP:0100787)2.49991835
59Nasal polyposis (HP:0100582)2.49614935
60Neurofibrillary tangles (HP:0002185)2.49393837
61Abnormality of the nasal mucosa (HP:0000433)2.49178789
62Increased IgE level (HP:0003212)2.46089398
63Leukocytosis (HP:0001974)2.43204649
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.42098267
65Gastrointestinal inflammation (HP:0004386)2.39894711
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.39526387
67Osteolytic defects of the hand bones (HP:0009699)2.39526387
68Upper motor neuron abnormality (HP:0002127)2.36304595
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34754639
70Vertebral compression fractures (HP:0002953)2.31307735
71Prolonged bleeding time (HP:0003010)2.30240642
72Encephalitis (HP:0002383)2.30070561
73Tetraparesis (HP:0002273)2.29306757
74Thrombocytosis (HP:0001894)2.27819108
75Emphysema (HP:0002097)2.26262114
76Basal ganglia calcification (HP:0002135)2.25503146
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25415335
78Neuronal loss in central nervous system (HP:0002529)2.24824099
79Glomerulonephritis (HP:0000099)2.23410438
80Hemoptysis (HP:0002105)2.21139649
81Gingival bleeding (HP:0000225)2.18168593
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.16489004
83Abnormal platelet function (HP:0011869)2.15264019
84Impaired platelet aggregation (HP:0003540)2.15264019
85Recurrent bronchitis (HP:0002837)2.11247103
86Keratoconjunctivitis sicca (HP:0001097)2.10933010
87T lymphocytopenia (HP:0005403)2.10460871
88Hepatosplenomegaly (HP:0001433)2.09235072
89Epistaxis (HP:0000421)2.07422220
90Premature loss of primary teeth (HP:0006323)2.07384588
91Thick nail (HP:0001805)2.04163528
92Progressive neurologic deterioration (HP:0002344)2.03930177
93Pulmonary embolism (HP:0002204)2.03271877
94Nuclear cataract (HP:0100018)2.02583840
95Episodic fever (HP:0001954)2.01426126
96Cerebral aneurysm (HP:0004944)2.01065128
97IgM deficiency (HP:0002850)2.00890553
98Diminished motivation (HP:0000745)2.00466675
99Pathologic fracture (HP:0002756)1.99883672
100Recurrent pneumonia (HP:0006532)1.98611117
101Peritonitis (HP:0002586)1.98186167
102Restrictive lung disease (HP:0002091)1.97788566
103Apathy (HP:0000741)1.97335827
104Nephritis (HP:0000123)1.96789729
105Recurrent lower respiratory tract infections (HP:0002783)1.95565486
106Asymmetric septal hypertrophy (HP:0001670)1.94125858
107Albinism (HP:0001022)1.93132597
108Polycythemia (HP:0001901)1.92667488
109Spondylolisthesis (HP:0003302)1.92382899
110Abnormality of iron homeostasis (HP:0011031)1.92323313
111Abnormality of T cell number (HP:0011839)1.92149543
112Agnosia (HP:0010524)1.91725185
113Purpura (HP:0000979)1.91281377
114Polyneuropathy (HP:0001271)1.91078226
115Thoracic kyphosis (HP:0002942)1.88116486
116Segmental peripheral demyelination/remyelination (HP:0003481)1.87266913
117Increased IgM level (HP:0003496)1.86989968
118Cerebral inclusion bodies (HP:0100314)1.86811483
119Abnormality of the pleura (HP:0002103)1.85535430
120Increased CSF protein (HP:0002922)1.85352759
121Gastrointestinal stroma tumor (HP:0100723)1.85311013
122Keratoconjunctivitis (HP:0001096)1.85261071
123Malnutrition (HP:0004395)1.84370824
124Increased density of long bones (HP:0006392)1.83695609
125Increased serum ferritin (HP:0003281)1.83543271
126Chest pain (HP:0100749)1.81441828
127Agammaglobulinemia (HP:0004432)1.80144138
128Abnormality of the pericardium (HP:0001697)1.79628166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.60990306
2TBK13.21649189
3KIT3.07783959
4BLK2.97635625
5PRPF4B2.81786489
6ERN12.73089191
7TYK22.72937874
8MAP3K142.70504361
9RIPK42.65655876
10IRAK42.56169157
11IRAK32.25949140
12IKBKE2.22677347
13JAK32.17550195
14TGFBR22.05741708
15ZAP702.03825795
16IKBKB2.00811908
17TRIB31.97249730
18TXK1.95744379
19CSF1R1.89150710
20EPHB11.71046605
21JAK11.67077668
22STK101.61869526
23BTK1.58990307
24CSK1.57809699
25HCK1.57459448
26MAP2K31.55366909
27PIM21.54278784
28TAOK31.54135111
29SYK1.53005917
30TTN1.51963101
31TNK21.46515723
32GRK71.46366973
33RPS6KA41.40362852
34MAP3K101.33728329
35DDR21.32037201
36MAP3K11.29063453
37CHUK1.28450332
38CDC42BPA1.28367417
39TEC1.26218304
40NME21.20494612
41PIM11.19371066
42FES1.19191433
43LCK1.18377886
44LRRK21.17957892
45PKN21.17318415
46RIPK11.14897795
47PTK61.14202552
48LYN1.11527542
49NEK91.09352662
50KSR21.05415852
51MATK1.04403770
52KDR1.03974282
53EEF2K1.03441031
54SIK21.02011058
55TESK21.01818127
56CDK120.97959456
57JAK20.95627540
58PRKD20.95066468
59TRPM70.94848930
60CAMK1D0.94405512
61ITK0.93720626
62BMX0.93554873
63MARK20.91233003
64MARK30.91028680
65PAK40.89180017
66FGR0.88465254
67CAMKK20.88017861
68MAP3K130.86880338
69PDPK10.84564705
70STK40.84108412
71CLK10.82415332
72FLT30.80189324
73IRAK20.79764820
74FGFR40.76958969
75SMG10.76116384
76CDK60.75886620
77SCYL20.75695935
78GRK60.74732765
79MAPK120.71964080
80MAP3K30.71627803
81MAP3K60.70889594
82FGFR30.70730501
83MAPK70.69642107
84IRAK10.68828661
85ABL10.63221160
86BMPR20.62040468
87RPS6KA60.61322342
88EGFR0.60206288
89STK30.58729989
90MAP3K110.55757064
91NEK20.54420342
92MAPKAPK20.54017325
93ACVR1B0.51574902
94PRKCD0.50818332
95DAPK20.48364125
96RPS6KL10.48234449
97RPS6KC10.48234449
98TGFBR10.43373896
99CAMK1G0.43007095
100CAMKK10.42951906
101CDK90.42763918
102SIK30.41950999
103MAP3K80.41460912
104EPHA30.41449026
105MOS0.41338589
106CDK40.41083351
107TAOK20.40260561
108MAP3K50.39682098
109PDGFRB0.39365663
110SGK30.38750456
111PDGFRA0.38226510
112PIK3CG0.38125671
113ARAF0.38021476
114RPS6KA20.36917375
115TESK10.36588347
116ABL20.36096182
117MAP3K20.35297731
118DMPK0.35291177
119DYRK1B0.34472307
120PAK20.33305700
121FYN0.32986334
122PDK10.32624238
123ALK0.31273766
124TAOK10.30340087
125PRKCH0.30073166
126YES10.29192614
127PRKG20.29188026
128MAPK40.28362012
129SIK10.27531517

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.28088272
2Osteoclast differentiation_Homo sapiens_hsa043802.66484179
3Staphylococcus aureus infection_Homo sapiens_hsa051502.54278886
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43663777
5Malaria_Homo sapiens_hsa051442.42647018
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.41006179
7B cell receptor signaling pathway_Homo sapiens_hsa046622.21713671
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.18609759
9Lysosome_Homo sapiens_hsa041422.11850319
10Pertussis_Homo sapiens_hsa051332.10981232
11Tuberculosis_Homo sapiens_hsa051522.05134918
12Legionellosis_Homo sapiens_hsa051342.04443185
13Measles_Homo sapiens_hsa051621.99711760
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93043018
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82097206
16Antigen processing and presentation_Homo sapiens_hsa046121.80178062
17Other glycan degradation_Homo sapiens_hsa005111.75498884
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72335922
19Hematopoietic cell lineage_Homo sapiens_hsa046401.71728186
20Graft-versus-host disease_Homo sapiens_hsa053321.70984887
21Toxoplasmosis_Homo sapiens_hsa051451.67740147
22TNF signaling pathway_Homo sapiens_hsa046681.65196347
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61845436
24Apoptosis_Homo sapiens_hsa042101.61798805
25Influenza A_Homo sapiens_hsa051641.61718520
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58633092
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58190897
28Phagosome_Homo sapiens_hsa041451.55130874
29Shigellosis_Homo sapiens_hsa051311.54996082
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53748655
31Rheumatoid arthritis_Homo sapiens_hsa053231.53312897
32Allograft rejection_Homo sapiens_hsa053301.51448632
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.49776317
34Salmonella infection_Homo sapiens_hsa051321.47580849
35Herpes simplex infection_Homo sapiens_hsa051681.42807209
36Primary immunodeficiency_Homo sapiens_hsa053401.42029932
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35257373
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.33304324
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30345035
40Hepatitis B_Homo sapiens_hsa051611.29232958
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26880675
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.25864655
43Chronic myeloid leukemia_Homo sapiens_hsa052201.24772128
44Chemokine signaling pathway_Homo sapiens_hsa040621.23341728
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18846667
46Asthma_Homo sapiens_hsa053101.16729365
47African trypanosomiasis_Homo sapiens_hsa051431.13887204
48Acute myeloid leukemia_Homo sapiens_hsa052211.13222402
49Viral myocarditis_Homo sapiens_hsa054161.12631155
50T cell receptor signaling pathway_Homo sapiens_hsa046601.08673885
51Amoebiasis_Homo sapiens_hsa051461.04384135
52* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03988866
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03113547
54Platelet activation_Homo sapiens_hsa046111.00839386
55Pancreatic cancer_Homo sapiens_hsa052120.98595266
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92763607
57Hepatitis C_Homo sapiens_hsa051600.91925132
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.89598767
59Small cell lung cancer_Homo sapiens_hsa052220.87369358
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84695238
61Caffeine metabolism_Homo sapiens_hsa002320.83585819
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80202931
63Collecting duct acid secretion_Homo sapiens_hsa049660.78192936
64Epstein-Barr virus infection_Homo sapiens_hsa051690.76269342
65Bladder cancer_Homo sapiens_hsa052190.76191712
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72435723
67Viral carcinogenesis_Homo sapiens_hsa052030.72319594
68Proteoglycans in cancer_Homo sapiens_hsa052050.70136821
69HIF-1 signaling pathway_Homo sapiens_hsa040660.67035600
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.66665731
71Type I diabetes mellitus_Homo sapiens_hsa049400.66453624
72Prolactin signaling pathway_Homo sapiens_hsa049170.65257181
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64615872
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62990110
75Complement and coagulation cascades_Homo sapiens_hsa046100.62914335
76VEGF signaling pathway_Homo sapiens_hsa043700.62341559
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61852535
78HTLV-I infection_Homo sapiens_hsa051660.61710758
79Endocytosis_Homo sapiens_hsa041440.59619974
80Notch signaling pathway_Homo sapiens_hsa043300.59040688
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58748753
82Focal adhesion_Homo sapiens_hsa045100.56556437
83GnRH signaling pathway_Homo sapiens_hsa049120.55931866
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52235006
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.52024852
86p53 signaling pathway_Homo sapiens_hsa041150.51999279
87MicroRNAs in cancer_Homo sapiens_hsa052060.51150603
88Insulin resistance_Homo sapiens_hsa049310.49187654
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49167278
90Non-small cell lung cancer_Homo sapiens_hsa052230.49031919
91Autoimmune thyroid disease_Homo sapiens_hsa053200.45398463
92Vibrio cholerae infection_Homo sapiens_hsa051100.44380930
93Galactose metabolism_Homo sapiens_hsa000520.41884455
94Colorectal cancer_Homo sapiens_hsa052100.38283568
95FoxO signaling pathway_Homo sapiens_hsa040680.37942097
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37249889
97Rap1 signaling pathway_Homo sapiens_hsa040150.36992216
98mTOR signaling pathway_Homo sapiens_hsa041500.35546349
99Endometrial cancer_Homo sapiens_hsa052130.35381385
100Estrogen signaling pathway_Homo sapiens_hsa049150.33671040
101Renal cell carcinoma_Homo sapiens_hsa052110.30608113
102Sphingolipid metabolism_Homo sapiens_hsa006000.30437152
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29986204
104Prion diseases_Homo sapiens_hsa050200.29687413
105ECM-receptor interaction_Homo sapiens_hsa045120.28315282
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.27074074
107Prostate cancer_Homo sapiens_hsa052150.24854231
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24814715
109Type II diabetes mellitus_Homo sapiens_hsa049300.23799092
110MAPK signaling pathway_Homo sapiens_hsa040100.23634876
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23546131
112Renin-angiotensin system_Homo sapiens_hsa046140.23034867

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