PLEKHJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.47172361
2positive regulation of prostaglandin secretion (GO:0032308)5.75424082
3ribosomal small subunit assembly (GO:0000028)5.64872000
4histone arginine methylation (GO:0034969)4.85260905
5viral transcription (GO:0019083)4.72728449
6translational termination (GO:0006415)4.58007348
7regulation of prostaglandin secretion (GO:0032306)4.53075064
8telomere maintenance via semi-conservative replication (GO:0032201)4.46073189
9DNA strand elongation involved in DNA replication (GO:0006271)4.40098157
10regulation of mitochondrial translation (GO:0070129)4.35793628
11DNA strand elongation (GO:0022616)4.21918909
12protein targeting to mitochondrion (GO:0006626)4.20214063
13ribosomal small subunit biogenesis (GO:0042274)4.18322259
14translational elongation (GO:0006414)4.14374769
15ATP synthesis coupled proton transport (GO:0015986)4.09834747
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.09834747
17peptidyl-arginine omega-N-methylation (GO:0035247)4.09749906
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09425049
19base-excision repair, AP site formation (GO:0006285)4.07667305
20GDP-mannose metabolic process (GO:0019673)4.06019799
21cotranslational protein targeting to membrane (GO:0006613)3.99721545
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98362744
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.97929783
24NADH dehydrogenase complex assembly (GO:0010257)3.97929783
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97929783
26protein targeting to ER (GO:0045047)3.97452071
27establishment of protein localization to mitochondrion (GO:0072655)3.95981149
28maturation of SSU-rRNA (GO:0030490)3.93403319
29proteasome assembly (GO:0043248)3.92369367
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90985938
31pyrimidine nucleotide catabolic process (GO:0006244)3.85544647
32telomere maintenance via recombination (GO:0000722)3.85062921
33protein complex biogenesis (GO:0070271)3.84593703
34mitochondrial respiratory chain complex assembly (GO:0033108)3.80757503
35protein localization to endoplasmic reticulum (GO:0070972)3.79328161
36DNA replication initiation (GO:0006270)3.78310926
37chaperone-mediated protein transport (GO:0072321)3.76237182
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.76016061
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73990056
40translational initiation (GO:0006413)3.73582132
41viral life cycle (GO:0019058)3.65837557
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.64177955
43protein localization to mitochondrion (GO:0070585)3.60609548
44ribosomal large subunit biogenesis (GO:0042273)3.53995436
45cellular protein complex disassembly (GO:0043624)3.52819924
46peptidyl-histidine modification (GO:0018202)3.52539840
47oxidative phosphorylation (GO:0006119)3.52364221
48DNA replication-dependent nucleosome organization (GO:0034723)3.50796216
49DNA replication-dependent nucleosome assembly (GO:0006335)3.50796216
50positive regulation of icosanoid secretion (GO:0032305)3.50211142
51formation of translation preinitiation complex (GO:0001731)3.45207844
52deoxyribose phosphate catabolic process (GO:0046386)3.44045970
53peptidyl-arginine N-methylation (GO:0035246)3.38356090
54peptidyl-arginine methylation (GO:0018216)3.38356090
55mitotic recombination (GO:0006312)3.36992953
56ribonucleoprotein complex biogenesis (GO:0022613)3.33457106
57telomere maintenance via telomere lengthening (GO:0010833)3.33052731
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.29959358
59pseudouridine synthesis (GO:0001522)3.27785120
60respiratory chain complex IV assembly (GO:0008535)3.27532172
61DNA replication checkpoint (GO:0000076)3.27522945
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25193068
63L-serine metabolic process (GO:0006563)3.24667709
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.24109227
65translation (GO:0006412)3.20357924
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19476566
67pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18182822
68respiratory electron transport chain (GO:0022904)3.17787688
69cytochrome complex assembly (GO:0017004)3.16280066
70purine deoxyribonucleotide catabolic process (GO:0009155)3.15695963
71protein complex disassembly (GO:0043241)3.13932989
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13702317
73electron transport chain (GO:0022900)3.13181263
74positive regulation of fatty acid transport (GO:2000193)3.11691917
75inner mitochondrial membrane organization (GO:0007007)3.11340977
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09717460
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09717460
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06133261
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05526343
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.03269234
81termination of RNA polymerase III transcription (GO:0006386)3.03269234
82rRNA processing (GO:0006364)3.03228847
83CTP biosynthetic process (GO:0006241)3.01660623
84CTP metabolic process (GO:0046036)3.01660623
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01135024
86negative regulation of ligase activity (GO:0051352)3.01135024
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00547952
88protein neddylation (GO:0045116)3.00353470
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98798889
90ribosome biogenesis (GO:0042254)2.98285744
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98051372
92spliceosomal snRNP assembly (GO:0000387)2.98013747
93macromolecular complex disassembly (GO:0032984)2.97989182
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95721724
95nuclear-transcribed mRNA catabolic process (GO:0000956)2.94753841
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94690999
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94407224
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94407224
99DNA unwinding involved in DNA replication (GO:0006268)2.93927750
100transcription from mitochondrial promoter (GO:0006390)2.93801667
101sequestering of actin monomers (GO:0042989)2.93794040
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93240289
103establishment of integrated proviral latency (GO:0075713)2.92925143
104guanosine-containing compound biosynthetic process (GO:1901070)2.92426532
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91823395
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91823395
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91823395
108transcription-coupled nucleotide-excision repair (GO:0006283)2.91203493
109rRNA metabolic process (GO:0016072)2.90785084
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89941837
111mitochondrial transport (GO:0006839)2.89350141
112rRNA transcription (GO:0009303)2.89174232
113response to interferon-beta (GO:0035456)2.87260788
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86204373
115CENP-A containing nucleosome assembly (GO:0034080)2.86086548
116rRNA modification (GO:0000154)2.85775208
117metallo-sulfur cluster assembly (GO:0031163)2.85436065
118iron-sulfur cluster assembly (GO:0016226)2.85436065
119mRNA catabolic process (GO:0006402)2.81980735
120signal transduction involved in DNA damage checkpoint (GO:0072422)2.81699461
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81699461
122deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81368994
123base-excision repair (GO:0006284)2.80983838
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79934091
125tRNA modification (GO:0006400)2.79879940
126release of cytochrome c from mitochondria (GO:0001836)2.78913941
127tRNA processing (GO:0008033)2.78703103
128DNA damage response, detection of DNA damage (GO:0042769)2.77429166
129pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.77056024
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.76795622
131cellular component biogenesis (GO:0044085)2.76461065
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76119243
133cullin deneddylation (GO:0010388)2.76109232
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75675904
135chromatin remodeling at centromere (GO:0031055)2.75541487
136IMP biosynthetic process (GO:0006188)2.75367294
137mitochondrial fusion (GO:0008053)2.75128839
138RNA catabolic process (GO:0006401)2.74727760
139ubiquinone biosynthetic process (GO:0006744)2.74494810
140nucleobase biosynthetic process (GO:0046112)2.74113018
1412-deoxyribonucleotide metabolic process (GO:0009394)2.73525564
142GTP biosynthetic process (GO:0006183)2.73172426
143regulation of cellular amino acid metabolic process (GO:0006521)2.69434408
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65693728
145establishment of viral latency (GO:0019043)2.64709193
146viral mRNA export from host cell nucleus (GO:0046784)2.64245096
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63899699
148G1/S transition of mitotic cell cycle (GO:0000082)2.63519067
149cell cycle G1/S phase transition (GO:0044843)2.63519067
150purine-containing compound salvage (GO:0043101)2.60259591
151protein targeting to membrane (GO:0006612)2.58447084
152regulation of protein heterodimerization activity (GO:0043497)2.57610113
153folic acid-containing compound biosynthetic process (GO:0009396)2.56664973
154positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.56557510
1557-methylguanosine mRNA capping (GO:0006370)2.55744278
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55221896
157antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55221896
158deoxyribonucleotide catabolic process (GO:0009264)2.52703391
159positive regulation of ligase activity (GO:0051351)2.52624608
160deoxyribose phosphate biosynthetic process (GO:0046385)2.52519591
1612-deoxyribonucleotide biosynthetic process (GO:0009265)2.52519591
162DNA replication-independent nucleosome assembly (GO:0006336)2.52399733
163DNA replication-independent nucleosome organization (GO:0034724)2.52399733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74869118
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92559417
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74619983
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00813271
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.00016463
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93415362
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86044412
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.85384615
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77587741
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.73885924
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58876129
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56788437
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48333521
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47240953
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43556954
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43242298
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37656755
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35637422
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28032233
20VDR_23849224_ChIP-Seq_CD4+_Human2.25757666
21XRN2_22483619_ChIP-Seq_HELA_Human2.23254484
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17724758
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10732712
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03564575
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01789527
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01529440
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96024430
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95926263
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91510511
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90752083
31FOXP3_21729870_ChIP-Seq_TREG_Human1.89651322
32* GABP_19822575_ChIP-Seq_HepG2_Human1.86669570
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.85078166
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.84473690
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.82978842
36MYC_22102868_ChIP-Seq_BL_Human1.80331709
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77377605
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76216533
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72158253
40VDR_21846776_ChIP-Seq_THP-1_Human1.70635537
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69797996
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69504276
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69379026
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.66247429
45TTF2_22483619_ChIP-Seq_HELA_Human1.66036666
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65091882
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64368684
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.63006365
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60100057
50SPI1_23547873_ChIP-Seq_NB4_Human1.59773905
51* TET1_21451524_ChIP-Seq_MESCs_Mouse1.58695985
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56499397
53CIITA_25753668_ChIP-Seq_RAJI_Human1.53898407
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53773917
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.50863392
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47134382
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46470713
58* FOXP1_21924763_ChIP-Seq_HESCs_Human1.44137465
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40310083
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40222994
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38920245
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.38451331
63ELK1_19687146_ChIP-ChIP_HELA_Human1.36576458
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36040518
65P68_20966046_ChIP-Seq_HELA_Human1.35506171
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34152403
67BCL6_27268052_Chip-Seq_Bcells_Human1.33901332
68* E2F1_21310950_ChIP-Seq_MCF-7_Human1.33454005
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33170806
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32988734
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32823920
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32572336
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32345475
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32006624
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31961766
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30828755
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27633061
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26860285
79SCL_19346495_ChIP-Seq_HPC-7_Human1.26143098
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25950417
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25855941
82* ELF1_20517297_ChIP-Seq_JURKAT_Human1.24039773
83* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23960622
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.23460868
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.22664523
86MYC_18940864_ChIP-ChIP_HL60_Human1.22515239
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19646203
88PHF8_20622854_ChIP-Seq_HELA_Human1.19394484
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18051665
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17021489
91KDM5A_27292631_Chip-Seq_BREAST_Human1.16225135
92* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15972824
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15972523
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15483318
95LXR_22292898_ChIP-Seq_THP-1_Human1.14331551
96TFEB_21752829_ChIP-Seq_HELA_Human1.14017815
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.11698753
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11344216
99BCOR_27268052_Chip-Seq_Bcells_Human1.11142529
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11054691
101MAF_26560356_Chip-Seq_TH1_Human1.09582790
102* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09076061
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08985412
104MYB_26560356_Chip-Seq_TH2_Human1.07773173
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07632202
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07547655
107BP1_19119308_ChIP-ChIP_Hs578T_Human1.06708168
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05659523
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05383916
110MAF_26560356_Chip-Seq_TH2_Human1.03665434
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03295616
112VDR_24763502_ChIP-Seq_THP-1_Human1.02281984
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02048619
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.01411312
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01266517
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01214757
117MYB_26560356_Chip-Seq_TH1_Human1.00893668
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00742374
119UTX_26944678_Chip-Seq_JUKART_Human1.00370841
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00193474
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99633509
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99110391
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98078855
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97333026
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97243897
126E2F1_20622854_ChIP-Seq_HELA_Human0.96288485
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96122542
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95320018
129* RARA_24833708_ChIP-Seq_LIVER_Mouse0.95067467
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94664507
131AR_21909140_ChIP-Seq_LNCAP_Human0.94523359
132SA1_27219007_Chip-Seq_Bcells_Human0.94234844
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93979881
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93960143
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93619450
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93040077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.59374691
2MP0001835_abnormal_antigen_presentation3.41422359
3MP0010094_abnormal_chromosome_stability3.08096266
4MP0004957_abnormal_blastocyst_morpholog2.81647826
5MP0005671_abnormal_response_to2.79028164
6MP0003077_abnormal_cell_cycle2.77353639
7MP0009785_altered_susceptibility_to2.69469795
8MP0003111_abnormal_nucleus_morphology2.65893057
9MP0000685_abnormal_immune_system2.65892972
10MP0002396_abnormal_hematopoietic_system2.61071993
11MP0003763_abnormal_thymus_physiology2.55957500
12MP0008057_abnormal_DNA_replication2.55819192
13MP0009333_abnormal_splenocyte_physiolog2.55548526
14MP0008058_abnormal_DNA_repair2.37235659
15MP0002398_abnormal_bone_marrow2.21889639
16MP0008007_abnormal_cellular_replicative2.20725861
17MP0000490_abnormal_crypts_of2.18641749
18MP0003436_decreased_susceptibility_to2.18057426
19MP0000537_abnormal_urethra_morphology2.17847325
20MP0005000_abnormal_immune_tolerance2.16271552
21MP0005025_abnormal_response_to2.16217845
22MP0001800_abnormal_humoral_immune2.11895782
23MP0002132_abnormal_respiratory_system2.05469526
24MP0002420_abnormal_adaptive_immunity2.04136565
25MP0002723_abnormal_immune_serum2.03469028
26MP0002452_abnormal_antigen_presenting2.02958858
27MP0001819_abnormal_immune_cell2.02823368
28MP0002148_abnormal_hypersensitivity_rea1.99654730
29MP0000689_abnormal_spleen_morphology1.97419403
30MP0005397_hematopoietic_system_phenotyp1.95233275
31MP0001545_abnormal_hematopoietic_system1.95233275
32MP0008789_abnormal_olfactory_epithelium1.93562588
33MP0008872_abnormal_physiological_respon1.91349432
34MP0002722_abnormal_immune_system1.91106950
35MP0002822_catalepsy1.89225651
36MP0005499_abnormal_olfactory_system1.87824750
37MP0005394_taste/olfaction_phenotype1.87824750
38MP0000716_abnormal_immune_system1.87016092
39MP0004858_abnormal_nervous_system1.86279641
40MP0004133_heterotaxia1.82890171
41MP0002429_abnormal_blood_cell1.78828855
42MP0002405_respiratory_system_inflammati1.77627785
43MP0003186_abnormal_redox_activity1.77313541
44MP0001853_heart_inflammation1.77093918
45MP0005075_abnormal_melanosome_morpholog1.76146881
46MP0002419_abnormal_innate_immunity1.73658912
47MP0006082_CNS_inflammation1.73656024
48MP0001188_hyperpigmentation1.70195754
49MP0001790_abnormal_immune_system1.69166839
50MP0005387_immune_system_phenotype1.69166839
51MP0005360_urolithiasis1.65656208
52MP0003724_increased_susceptibility_to1.65164923
53MP0008932_abnormal_embryonic_tissue1.60786423
54MP0002254_reproductive_system_inflammat1.59824980
55MP0003806_abnormal_nucleotide_metabolis1.59501592
56MP0003283_abnormal_digestive_organ1.58946614
57MP0000703_abnormal_thymus_morphology1.58558182
58MP0005083_abnormal_biliary_tract1.58282701
59MP0005464_abnormal_platelet_physiology1.56705120
60MP0002736_abnormal_nociception_after1.55807217
61MP0002019_abnormal_tumor_incidence1.55799036
62MP0002102_abnormal_ear_morphology1.54633366
63MP0003656_abnormal_erythrocyte_physiolo1.54342641
64MP0004808_abnormal_hematopoietic_stem1.52020765
65MP0002006_tumorigenesis1.49289987
66MP0009764_decreased_sensitivity_to1.47047145
67MP0000858_altered_metastatic_potential1.46774550
68MP0003119_abnormal_digestive_system1.44618387
69MP0010155_abnormal_intestine_physiology1.43804459
70MP0002166_altered_tumor_susceptibility1.43465588
71MP0006054_spinal_hemorrhage1.39785195
72MP0000313_abnormal_cell_death1.38499723
73MP0000372_irregular_coat_pigmentation1.38386403
74MP0002938_white_spotting1.36664391
75MP0000049_abnormal_middle_ear1.34855546
76MP0004147_increased_porphyrin_level1.34546049
77MP0003786_premature_aging1.33958863
78MP0005670_abnormal_white_adipose1.33175168
79MP0005174_abnormal_tail_pigmentation1.32642653
80MP0003221_abnormal_cardiomyocyte_apopto1.30578568
81MP0000350_abnormal_cell_proliferation1.26473973
82MP0001845_abnormal_inflammatory_respons1.26153162
83MP0002653_abnormal_ependyma_morphology1.25511484
84MP0001873_stomach_inflammation1.25225980
85MP0006276_abnormal_autonomic_nervous1.23986764
86MP0000465_gastrointestinal_hemorrhage1.18684456
87MP0000538_abnormal_urinary_bladder1.18332284
88MP0010030_abnormal_orbit_morphology1.18081570
89MP0002638_abnormal_pupillary_reflex1.17326636
90MP0002160_abnormal_reproductive_system1.15176933
91MP0003121_genomic_imprinting1.13140448
92MP0003646_muscle_fatigue1.10175458
93MP0008469_abnormal_protein_level1.09235707
94MP0001293_anophthalmia1.09193580
95MP0001727_abnormal_embryo_implantation1.08383528
96MP0005410_abnormal_fertilization1.07416534
97MP0003866_abnormal_defecation1.06898455
98MP0001730_embryonic_growth_arrest1.05967302
99MP0003137_abnormal_impulse_conducting1.03392890
100MP0009379_abnormal_foot_pigmentation1.03099044
101MP0006036_abnormal_mitochondrial_physio1.02293986
102MP0005645_abnormal_hypothalamus_physiol1.02004852
103MP0009278_abnormal_bone_marrow1.00585185
104MP0003567_abnormal_fetal_cardiomyocyte1.00158190
105MP0010307_abnormal_tumor_latency0.96028079
106MP0010352_gastrointestinal_tract_polyps0.95841318
107MP0008995_early_reproductive_senescence0.93408647
108MP0001968_abnormal_touch/_nociception0.93145867
109MP0003123_paternal_imprinting0.92416511
110MP0000358_abnormal_cell_content/0.91451360
111MP0005451_abnormal_body_composition0.91057159
112MP0000516_abnormal_urinary_system0.90882214
113MP0005367_renal/urinary_system_phenotyp0.90882214
114MP0002139_abnormal_hepatobiliary_system0.90727739
115MP0002095_abnormal_skin_pigmentation0.90717595
116MP0008877_abnormal_DNA_methylation0.87652624
117MP0004947_skin_inflammation0.87578888
118MP0003718_maternal_effect0.86517978
119MP0001929_abnormal_gametogenesis0.86119178
120MP0005332_abnormal_amino_acid0.84746557
121MP0002080_prenatal_lethality0.83779191
122MP0003448_altered_tumor_morphology0.81966341
123MP0005058_abnormal_lysosome_morphology0.81937548
124MP0004019_abnormal_vitamin_homeostasis0.81046768
125MP0003698_abnormal_male_reproductive0.80970040
126MP0001919_abnormal_reproductive_system0.80946336
127MP0005310_abnormal_salivary_gland0.80611189
128MP0000653_abnormal_sex_gland0.80204497
129MP0005584_abnormal_enzyme/coenzyme_acti0.80058170
130MP0000015_abnormal_ear_pigmentation0.79667078
131MP0005084_abnormal_gallbladder_morpholo0.79080810
132MP0000343_altered_response_to0.78703583
133MP0001533_abnormal_skeleton_physiology0.77715058
134MP0002111_abnormal_tail_morphology0.77610914
135MP0001986_abnormal_taste_sensitivity0.77236316
136MP0003136_yellow_coat_color0.76988721
137MP0003787_abnormal_imprinting0.76752420
138MP0001905_abnormal_dopamine_level0.75755695
139MP0005636_abnormal_mineral_homeostasis0.75540566
140MP0002933_joint_inflammation0.74828697
141MP0006292_abnormal_olfactory_placode0.74218773
142MP0001529_abnormal_vocalization0.73567454
143MP0005389_reproductive_system_phenotype0.73546254
144MP0002085_abnormal_embryonic_tissue0.72632431
145MP0005381_digestive/alimentary_phenotyp0.71276078
146MP0001984_abnormal_olfaction0.71081337
147MP0002876_abnormal_thyroid_physiology0.70969917
148MP0001697_abnormal_embryo_size0.70863233
149MP0002210_abnormal_sex_determination0.70579057
150MP0000631_abnormal_neuroendocrine_gland0.70062475
151MP0008770_decreased_survivor_rate0.69941806
152MP0003122_maternal_imprinting0.69810751
153MP0000462_abnormal_digestive_system0.69267582
154MP0008260_abnormal_autophagy0.69158222
155MP0006035_abnormal_mitochondrial_morpho0.66198153
156MP0001764_abnormal_homeostasis0.65888943
157MP0009840_abnormal_foam_cell0.64535297
158MP0000477_abnormal_intestine_morphology0.64176390
159MP0001119_abnormal_female_reproductive0.63876770
160MP0001145_abnormal_male_reproductive0.60965010
161MP0003315_abnormal_perineum_morphology0.59431976
162MP0001663_abnormal_digestive_system0.59068564
163MP0002163_abnormal_gland_morphology0.58646434
164MP0008873_increased_physiological_sensi0.57956239

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.99809235
2Abnormality of cells of the erythroid lineage (HP:0012130)4.96744285
3Reticulocytopenia (HP:0001896)4.30384406
4Aplastic anemia (HP:0001915)4.17948352
5Acute encephalopathy (HP:0006846)4.15572627
6Elevated erythrocyte sedimentation rate (HP:0003565)4.09468363
7Thrombocytosis (HP:0001894)3.60287753
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56278088
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56278088
10Recurrent abscess formation (HP:0002722)3.43362307
11Birth length less than 3rd percentile (HP:0003561)3.30458813
12Pallor (HP:0000980)3.30143578
13IgM deficiency (HP:0002850)3.29600895
14Hyperglycinemia (HP:0002154)3.28194653
15Lactic acidosis (HP:0003128)3.18597178
16Petechiae (HP:0000967)3.18028395
17Type II lissencephaly (HP:0007260)3.17164906
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.16717417
19Oral leukoplakia (HP:0002745)3.15846594
20Cerebral edema (HP:0002181)3.09482202
21Progressive macrocephaly (HP:0004481)3.07029666
22Type I transferrin isoform profile (HP:0003642)3.04439846
23Recurrent bacterial skin infections (HP:0005406)3.03066251
24Macrocytic anemia (HP:0001972)3.00626813
25Hypoplasia of the pons (HP:0012110)2.99105243
26Hyperglycinuria (HP:0003108)2.93526466
27Poor head control (HP:0002421)2.88803676
28Chronic otitis media (HP:0000389)2.88618164
29Myositis (HP:0100614)2.86827772
30Exertional dyspnea (HP:0002875)2.86608924
31Cerebellar dysplasia (HP:0007033)2.84977839
32Microvesicular hepatic steatosis (HP:0001414)2.79382247
33Abnormality of T cell physiology (HP:0011840)2.75128283
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69775517
35Microretrognathia (HP:0000308)2.67939914
363-Methylglutaconic aciduria (HP:0003535)2.64140864
37Hepatocellular necrosis (HP:0001404)2.63342207
38Panhypogammaglobulinemia (HP:0003139)2.60554755
39Abnormality of serine family amino acid metabolism (HP:0010894)2.59914123
40Abnormality of glycine metabolism (HP:0010895)2.59914123
41Reduced antithrombin III activity (HP:0001976)2.59769178
42Pancytopenia (HP:0001876)2.58930262
43IgG deficiency (HP:0004315)2.58104126
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57192911
45Dicarboxylic aciduria (HP:0003215)2.57192911
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56996022
47Abnormality of T cells (HP:0002843)2.54520599
48Abnormality of the pons (HP:0007361)2.53469578
49Muscle fiber atrophy (HP:0100295)2.48404513
50Respiratory failure (HP:0002878)2.47948821
51Increased hepatocellular lipid droplets (HP:0006565)2.47923576
52Agnosia (HP:0010524)2.46625244
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44719990
54Lymphoma (HP:0002665)2.43770885
55Mediastinal lymphadenopathy (HP:0100721)2.43126181
56Type 2 muscle fiber atrophy (HP:0003554)2.43032187
57Cerebral hypomyelination (HP:0006808)2.42526921
58Abnormal protein glycosylation (HP:0012346)2.42152731
59Abnormal glycosylation (HP:0012345)2.42152731
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42152731
61Abnormal protein N-linked glycosylation (HP:0012347)2.42152731
62Increased serum lactate (HP:0002151)2.41406083
63Recurrent bronchitis (HP:0002837)2.38081806
64Rough bone trabeculation (HP:0100670)2.36934633
65Abnormal trabecular bone morphology (HP:0100671)2.36804211
66Recurrent viral infections (HP:0004429)2.36178470
67Leukodystrophy (HP:0002415)2.35378589
68Premature graying of hair (HP:0002216)2.34049485
69Increased intramyocellular lipid droplets (HP:0012240)2.31075575
70Mitochondrial inheritance (HP:0001427)2.31059688
71Exercise intolerance (HP:0003546)2.30683748
72Eczematoid dermatitis (HP:0000976)2.29571734
73Horseshoe kidney (HP:0000085)2.29283667
74Combined immunodeficiency (HP:0005387)2.29125569
75Recurrent skin infections (HP:0001581)2.28328786
76Severe combined immunodeficiency (HP:0004430)2.27213111
77Bone marrow hypocellularity (HP:0005528)2.26151147
78Hepatic necrosis (HP:0002605)2.23394693
79Recurrent fungal infections (HP:0002841)2.22596789
80Methylmalonic aciduria (HP:0012120)2.21833188
81Lethargy (HP:0001254)2.21678599
82Degeneration of anterior horn cells (HP:0002398)2.20331998
83Abnormality of the anterior horn cell (HP:0006802)2.20331998
84Pulmonary fibrosis (HP:0002206)2.19469134
85Lipid accumulation in hepatocytes (HP:0006561)2.17246161
86Cerebral palsy (HP:0100021)2.16892710
87Breast hypoplasia (HP:0003187)2.16850029
8811 pairs of ribs (HP:0000878)2.16759123
89Abnormality of macrophages (HP:0004311)2.15391044
90Shoulder girdle muscle weakness (HP:0003547)2.14410421
91Asplenia (HP:0001746)2.13553801
92Glycosuria (HP:0003076)2.13033315
93Abnormality of urine glucose concentration (HP:0011016)2.13033315
94Increased IgM level (HP:0003496)2.11070866
95Respiratory difficulties (HP:0002880)2.10665714
96Recurrent cutaneous fungal infections (HP:0011370)2.10197011
97Chronic mucocutaneous candidiasis (HP:0002728)2.10197011
98Ragged-red muscle fibers (HP:0003200)2.09550586
99Myelodysplasia (HP:0002863)2.06774191
100Short femoral neck (HP:0100864)2.04558862
101Increased CSF lactate (HP:0002490)2.03775754
102Renal Fanconi syndrome (HP:0001994)2.01439593
103Nasal polyposis (HP:0100582)2.00290921
104Meningitis (HP:0001287)1.99500278
105Retinal dysplasia (HP:0007973)1.98591748
106Absent thumb (HP:0009777)1.98565051
107Pustule (HP:0200039)1.97446467
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97083614
109Hypoplasia of the brainstem (HP:0002365)1.97083614
110Chronic obstructive pulmonary disease (HP:0006510)1.97066862
111Obstructive lung disease (HP:0006536)1.97066862
112Increased muscle lipid content (HP:0009058)1.96556503
113Abnormality of cells of the lymphoid lineage (HP:0012140)1.96548709
114Lissencephaly (HP:0001339)1.96472011
115Lymphopenia (HP:0001888)1.95441800
116Carpal bone hypoplasia (HP:0001498)1.95429526
117Optic nerve coloboma (HP:0000588)1.93234270
118Cellular immunodeficiency (HP:0005374)1.92854022
119Colon cancer (HP:0003003)1.92188830
120Prolonged bleeding time (HP:0003010)1.91723254
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.91487325
122Hyperammonemia (HP:0001987)1.91413745
123Selective tooth agenesis (HP:0001592)1.90369365
124CNS demyelination (HP:0007305)1.90221418
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.89352278
126Neutropenia (HP:0001875)1.89080709
127Multiple enchondromatosis (HP:0005701)1.89035677
128T lymphocytopenia (HP:0005403)1.88721407
129Optic disc pallor (HP:0000543)1.87817195
130Increased serum ferritin (HP:0003281)1.86960589
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86515412
132Abnormality of serum amino acid levels (HP:0003112)1.85827122
133Chromsome breakage (HP:0040012)1.85511420
134Abnormal mitochondria in muscle tissue (HP:0008316)1.85270795
135Amaurosis fugax (HP:0100576)1.84696196
136Severe muscular hypotonia (HP:0006829)1.84691962
137Abnormality of reticulocytes (HP:0004312)1.84618991
138Opisthotonus (HP:0002179)1.84491981
139Nausea (HP:0002018)1.83859244
140Acute necrotizing encephalopathy (HP:0006965)1.83798490
141Emotional lability (HP:0000712)1.83390508
142Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.82548456
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78314642
144Abnormality of alanine metabolism (HP:0010916)1.78314642
145Hyperalaninemia (HP:0003348)1.78314642
146Myopathic facies (HP:0002058)1.77831944
147Cerebellar hypoplasia (HP:0001321)1.75822388
148Impulsivity (HP:0100710)1.73714401
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.72028339
150Anomalous pulmonary venous return (HP:0010772)1.70095167
151Increased serum pyruvate (HP:0003542)1.69641301
152Cleft eyelid (HP:0000625)1.68163809
153Abnormality of the labia minora (HP:0012880)1.67055063
154Pendular nystagmus (HP:0012043)1.65078315
155Congenital malformation of the right heart (HP:0011723)1.62979667
156Double outlet right ventricle (HP:0001719)1.62979667
157Blindness (HP:0000618)1.62863028
158Neoplasm of the pancreas (HP:0002894)1.61851072
159Patellar aplasia (HP:0006443)1.61082344
160Abnormality of glycolysis (HP:0004366)1.59200600
161Myokymia (HP:0002411)1.57988735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K75.98586955
2MAP3K44.93918385
3VRK23.53660194
4BUB13.52743088
5NME23.52433173
6ZAK3.52269179
7TESK23.24969106
8MAP2K42.90073637
9WEE12.86475832
10MAP4K12.82055514
11STK162.66055974
12PIM22.60271550
13EIF2AK12.35089676
14VRK12.11427229
15CDC72.06765800
16ACVR1B2.04031699
17BLK1.96827181
18TLK11.87956083
19EIF2AK31.84314993
20KDR1.84304756
21KIT1.74577476
22DYRK31.72848769
23IRAK41.71772475
24SRPK11.67956861
25TXK1.64275871
26PASK1.59470073
27TBK11.59329965
28BTK1.58334881
29MAP3K111.57819543
30CSNK1G31.49829914
31ZAP701.46641103
32RPS6KA41.36415306
33TEC1.35884235
34TESK11.35693315
35SMG11.34414924
36FLT31.33024800
37BRSK21.27378679
38NEK21.26416536
39SCYL21.24731966
40CSNK1G21.24279124
41PLK41.24055405
42TYK21.22820801
43JAK31.21589334
44PIM11.20845412
45CDK71.20198513
46IKBKE1.18690232
47CLK11.18464625
48CSNK1A1L1.15971947
49STK101.13912029
50PLK11.11199146
51PAK41.10141401
52CDK81.09931092
53CSF1R1.05122460
54IKBKB1.04819172
55CSNK1G11.03747210
56ATR1.03668876
57MKNK11.00068507
58SYK0.99510276
59MAP3K120.98993683
60CDK190.97636524
61RPS6KB20.95791330
62PBK0.93911989
63AURKB0.93570527
64MAP3K80.93302989
65LIMK10.92896926
66ARAF0.92673763
67TAF10.91976904
68GRK60.90792906
69LYN0.88608574
70LRRK20.88467387
71SIK30.87857530
72TGFBR10.86637420
73PDK20.86034217
74PRKCI0.85447104
75BRSK10.84912706
76NLK0.84107676
77TSSK60.83512345
78AURKA0.82779304
79STK40.80835886
80TRIB30.80410269
81MATK0.80035909
82MAPKAPK30.79915696
83ERN10.79698311
84NUAK10.79366917
85NME10.79364802
86BCKDK0.78873891
87MAP4K20.77456547
88CDK40.76989368
89EPHB20.74971015
90MAP2K30.74910331
91CCNB10.74477452
92CASK0.71806230
93MAP3K140.71463507
94IRAK30.70662212
95LCK0.69276436
96RPS6KA50.69031302
97ABL20.68880771
98TAOK20.66491073
99BRAF0.64929788
100MAP2K20.63161914
101CHEK20.62623071
102DAPK10.61560471
103RAF10.61530725
104EEF2K0.61167971
105MAPK130.61130766
106PAK10.59722217
107ILK0.56563363
108TTK0.56360081
109MAP3K100.55789045
110CSNK2A10.54308222
111NEK10.52699742
112MKNK20.52188869
113DYRK20.48946263
114PKN10.48443015
115EIF2AK20.47542327
116MUSK0.46426574
117RPS6KA60.46091254
118CSNK2A20.45150881
119ADRBK20.43681538
120DAPK30.43451257
121ITK0.42883357
122MAPKAPK50.41125391
123MAPK110.40695536
124CHEK10.38485990
125AKT20.38216585
126RET0.36997258
127TRIM280.36787374
128LMTK20.35790722
129OXSR10.34352370
130CSNK1A10.34158607
131CDK11A0.32961704
132WNK30.32885381
133GRK10.29822281
134PLK30.24619073
135DYRK1B0.24172109
136CDK20.23422830
137CDK140.21424778
138RPS6KA10.20882627
139BMX0.20393513
140PRKCZ0.19728194
141ATM0.17724010
142CDK150.17472519

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64642008
2Ribosome_Homo sapiens_hsa030104.35065527
3Proteasome_Homo sapiens_hsa030503.63220081
4Mismatch repair_Homo sapiens_hsa034303.54013348
5RNA polymerase_Homo sapiens_hsa030203.18550737
6Base excision repair_Homo sapiens_hsa034103.04530422
7Spliceosome_Homo sapiens_hsa030402.64797778
8Pyrimidine metabolism_Homo sapiens_hsa002402.57933906
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54414460
10Homologous recombination_Homo sapiens_hsa034402.51067205
11Nucleotide excision repair_Homo sapiens_hsa034202.44347961
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34764286
13Sulfur metabolism_Homo sapiens_hsa009202.28816476
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15656100
15Primary immunodeficiency_Homo sapiens_hsa053401.89949117
16RNA transport_Homo sapiens_hsa030131.84299089
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73882216
18Cell cycle_Homo sapiens_hsa041101.73524142
19One carbon pool by folate_Homo sapiens_hsa006701.66663622
20Non-homologous end-joining_Homo sapiens_hsa034501.56085088
21Fat digestion and absorption_Homo sapiens_hsa049751.54568782
22Protein export_Homo sapiens_hsa030601.52898491
23RNA degradation_Homo sapiens_hsa030181.51841196
24Fanconi anemia pathway_Homo sapiens_hsa034601.48857375
25Basal transcription factors_Homo sapiens_hsa030221.48115427
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47471998
27Antigen processing and presentation_Homo sapiens_hsa046121.46328596
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38041559
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34451338
30Folate biosynthesis_Homo sapiens_hsa007901.28478094
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28176598
32Purine metabolism_Homo sapiens_hsa002301.27231060
33Sulfur relay system_Homo sapiens_hsa041221.26649209
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26227796
35Herpes simplex infection_Homo sapiens_hsa051681.25517347
36Fatty acid elongation_Homo sapiens_hsa000621.23617767
37Fructose and mannose metabolism_Homo sapiens_hsa000511.22736616
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22623303
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22069614
40Vitamin digestion and absorption_Homo sapiens_hsa049771.20738148
41p53 signaling pathway_Homo sapiens_hsa041151.20048306
42Pyruvate metabolism_Homo sapiens_hsa006201.16556179
43Arginine and proline metabolism_Homo sapiens_hsa003301.16349252
44Legionellosis_Homo sapiens_hsa051341.16235794
45Leishmaniasis_Homo sapiens_hsa051401.14419558
46Carbon metabolism_Homo sapiens_hsa012001.14221377
47Parkinsons disease_Homo sapiens_hsa050121.12816808
48Epstein-Barr virus infection_Homo sapiens_hsa051691.12288079
49Vitamin B6 metabolism_Homo sapiens_hsa007501.12070865
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11681603
51Allograft rejection_Homo sapiens_hsa053301.10039475
52Graft-versus-host disease_Homo sapiens_hsa053321.09392424
53Measles_Homo sapiens_hsa051621.09314785
54Alcoholism_Homo sapiens_hsa050341.07862374
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02165688
56Oxidative phosphorylation_Homo sapiens_hsa001901.00617661
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.00442315
58Hematopoietic cell lineage_Homo sapiens_hsa046400.98890509
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98796973
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.98236742
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95438897
62Shigellosis_Homo sapiens_hsa051310.95200868
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93703243
64Peroxisome_Homo sapiens_hsa041460.93197170
65Huntingtons disease_Homo sapiens_hsa050160.93029494
66Pentose phosphate pathway_Homo sapiens_hsa000300.90293432
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87592969
68Systemic lupus erythematosus_Homo sapiens_hsa053220.83769228
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77931650
70Asthma_Homo sapiens_hsa053100.76590546
71Propanoate metabolism_Homo sapiens_hsa006400.76306069
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76263354
73mRNA surveillance pathway_Homo sapiens_hsa030150.76048824
74Cardiac muscle contraction_Homo sapiens_hsa042600.75483331
75Apoptosis_Homo sapiens_hsa042100.72514964
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71543784
77Steroid biosynthesis_Homo sapiens_hsa001000.70691832
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70673012
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.70586220
80Viral carcinogenesis_Homo sapiens_hsa052030.69815095
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69356569
82N-Glycan biosynthesis_Homo sapiens_hsa005100.69192984
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68866564
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67975910
85Arginine biosynthesis_Homo sapiens_hsa002200.66935111
86Butanoate metabolism_Homo sapiens_hsa006500.62881879
87Influenza A_Homo sapiens_hsa051640.61790445
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60933105
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60404198
90Tryptophan metabolism_Homo sapiens_hsa003800.59729027
91Glutathione metabolism_Homo sapiens_hsa004800.59504270
92Pertussis_Homo sapiens_hsa051330.59270394
93Hepatitis B_Homo sapiens_hsa051610.57878073
94Fatty acid metabolism_Homo sapiens_hsa012120.57456011
95Other glycan degradation_Homo sapiens_hsa005110.57395737
96B cell receptor signaling pathway_Homo sapiens_hsa046620.55817736
97Malaria_Homo sapiens_hsa051440.55423510
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54633741
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52906134
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.51946977
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51713870
102HTLV-I infection_Homo sapiens_hsa051660.51531250
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.51280831
104Renin-angiotensin system_Homo sapiens_hsa046140.50996642
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50377802
106Fatty acid degradation_Homo sapiens_hsa000710.48480173
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.48071752
108Salmonella infection_Homo sapiens_hsa051320.46828373
109Alzheimers disease_Homo sapiens_hsa050100.44595915
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43874036
111Acute myeloid leukemia_Homo sapiens_hsa052210.43188679
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43166641
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42129965
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41964827
115Thyroid cancer_Homo sapiens_hsa052160.41725793
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.41471985
117Tuberculosis_Homo sapiens_hsa051520.41078347
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40964313
119Glycerolipid metabolism_Homo sapiens_hsa005610.40013610
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38364433
121T cell receptor signaling pathway_Homo sapiens_hsa046600.37724311
122Osteoclast differentiation_Homo sapiens_hsa043800.36215158
123Biosynthesis of amino acids_Homo sapiens_hsa012300.35827877
124Viral myocarditis_Homo sapiens_hsa054160.35342793
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34099067
126Metabolic pathways_Homo sapiens_hsa011000.31451920
127Notch signaling pathway_Homo sapiens_hsa043300.31352875
128Galactose metabolism_Homo sapiens_hsa000520.30395945
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30317934
130Autoimmune thyroid disease_Homo sapiens_hsa053200.29532244
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.29177386
132Arachidonic acid metabolism_Homo sapiens_hsa005900.29051998
133Toxoplasmosis_Homo sapiens_hsa051450.27178637
134Type I diabetes mellitus_Homo sapiens_hsa049400.27087901
135Vibrio cholerae infection_Homo sapiens_hsa051100.26994761
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26597831
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26013009
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.25475243
139Selenocompound metabolism_Homo sapiens_hsa004500.24643259
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24621944
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24525273
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23941202
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22917827
144TNF signaling pathway_Homo sapiens_hsa046680.22290044
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19079817

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