PLEKHG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.81604545
2daunorubicin metabolic process (GO:0044597)7.81604545
3polyketide metabolic process (GO:0030638)7.81604545
4angiotensin maturation (GO:0002003)6.18289171
5hormone catabolic process (GO:0042447)5.88780336
6coenzyme catabolic process (GO:0009109)5.68647733
7diacylglycerol metabolic process (GO:0046339)5.63901780
8NADH metabolic process (GO:0006734)5.63691035
9sulfur amino acid catabolic process (GO:0000098)5.29349316
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.25493308
11cellular modified amino acid catabolic process (GO:0042219)5.24059342
12aminoglycoside antibiotic metabolic process (GO:0030647)5.14064435
13epoxygenase P450 pathway (GO:0019373)5.10050977
14regulation of guanylate cyclase activity (GO:0031282)5.02839729
15negative regulation of epidermis development (GO:0045683)4.87717906
16somite rostral/caudal axis specification (GO:0032525)4.77743491
17desmosome organization (GO:0002934)4.75255584
18low-density lipoprotein particle clearance (GO:0034383)4.50724985
19bundle of His cell to Purkinje myocyte communication (GO:0086069)4.47066083
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.33355988
21regulation of mammary gland epithelial cell proliferation (GO:0033599)4.31900351
22muscle organ morphogenesis (GO:0048644)4.26097219
23regulation of bile acid biosynthetic process (GO:0070857)4.25997689
24maintenance of protein location in nucleus (GO:0051457)4.25675127
25negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.20148640
26very-low-density lipoprotein particle assembly (GO:0034379)4.19600900
27vitamin A metabolic process (GO:0006776)4.17806310
28fat-soluble vitamin biosynthetic process (GO:0042362)4.16267787
29vitamin transmembrane transport (GO:0035461)4.15900937
30primary alcohol catabolic process (GO:0034310)4.12600893
31regulation of response to osmotic stress (GO:0047484)4.09655568
32plasma lipoprotein particle assembly (GO:0034377)4.02286597
33GDP-mannose metabolic process (GO:0019673)3.99345439
34flavonoid metabolic process (GO:0009812)3.98588807
35intestinal cholesterol absorption (GO:0030299)3.98186930
36L-phenylalanine metabolic process (GO:0006558)3.97831529
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97831529
38lipoprotein transport (GO:0042953)3.97624371
39negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.93704539
40nucleoside transmembrane transport (GO:1901642)3.90189442
41negative regulation of epidermal cell differentiation (GO:0045605)3.85612830
42triglyceride biosynthetic process (GO:0019432)3.84817284
43cellular glucuronidation (GO:0052695)3.84795402
44drug metabolic process (GO:0017144)3.84228685
45transcytosis (GO:0045056)3.81569073
46heme transport (GO:0015886)3.80354767
47intestinal absorption (GO:0050892)3.80303635
48L-phenylalanine catabolic process (GO:0006559)3.80095027
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80095027
50calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.73788004
51uronic acid metabolic process (GO:0006063)3.73033631
52glucuronate metabolic process (GO:0019585)3.73033631
53cytidine deamination (GO:0009972)3.72914478
54cytidine metabolic process (GO:0046087)3.72914478
55cytidine catabolic process (GO:0006216)3.72914478
56renal system process involved in regulation of blood volume (GO:0001977)3.68417378
57regulation of triglyceride catabolic process (GO:0010896)3.66497875
58neutral lipid biosynthetic process (GO:0046460)3.66437687
59acylglycerol biosynthetic process (GO:0046463)3.66437687
60phenol-containing compound catabolic process (GO:0019336)3.62313704
61regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.61085168
62endocrine process (GO:0050886)3.61085168
63regulation of systemic arterial blood pressure by hormone (GO:0001990)3.61085168
64protein-lipid complex assembly (GO:0065005)3.60266120
65cofactor catabolic process (GO:0051187)3.60201898
66response to dietary excess (GO:0002021)3.59685201
67ethanol oxidation (GO:0006069)3.59241202
68positive regulation of guanylate cyclase activity (GO:0031284)3.52166959
69proline biosynthetic process (GO:0006561)3.49330222
70negative regulation of cell cycle G2/M phase transition (GO:1902750)3.48904394
71positive regulation of fatty acid beta-oxidation (GO:0032000)3.48269914
72bile acid and bile salt transport (GO:0015721)3.48038364
73high-density lipoprotein particle remodeling (GO:0034375)3.47424922
74quinone metabolic process (GO:1901661)3.47419195
75aromatic amino acid family catabolic process (GO:0009074)3.47052146
76regulation of cholesterol esterification (GO:0010872)3.46885812
77triglyceride catabolic process (GO:0019433)3.46348185
78regulation of MHC class I biosynthetic process (GO:0045343)3.44935905
79positive regulation of lipid catabolic process (GO:0050996)3.44134246
80urea metabolic process (GO:0019627)3.41853984
81urea cycle (GO:0000050)3.41853984
82phenylpropanoid metabolic process (GO:0009698)3.41827266
83fructose metabolic process (GO:0006000)3.41517944
84cofactor transport (GO:0051181)3.41133982
85transepithelial transport (GO:0070633)3.40871334
86phospholipid efflux (GO:0033700)3.39805466
87omega-hydroxylase P450 pathway (GO:0097267)3.38944417
88notochord development (GO:0030903)3.38710573
89regulation of apoptotic process involved in morphogenesis (GO:1902337)3.35449890
90neutral lipid catabolic process (GO:0046461)3.35417073
91acylglycerol catabolic process (GO:0046464)3.35417073
92branching involved in mammary gland duct morphogenesis (GO:0060444)3.34458882
93receptor guanylyl cyclase signaling pathway (GO:0007168)3.33385262
94regulation of cholesterol metabolic process (GO:0090181)3.33304537
95L-ascorbic acid metabolic process (GO:0019852)3.32973570
96primitive streak formation (GO:0090009)3.32883551
97glycerol metabolic process (GO:0006071)3.32623126
98modified amino acid transport (GO:0072337)3.31091318
99thyroid hormone generation (GO:0006590)3.30437213
100rRNA transcription (GO:0009303)3.30289448
101regulation of cholesterol homeostasis (GO:2000188)3.29697348
102regulation of cGMP biosynthetic process (GO:0030826)3.29318412
103regulation of systemic arterial blood pressure (GO:0003073)3.29295057
104negative regulation of telomerase activity (GO:0051974)3.27650623
105positive regulation of pseudopodium assembly (GO:0031274)3.26039744
106sphingomyelin metabolic process (GO:0006684)3.25384613
107proline metabolic process (GO:0006560)3.24292678
108heterochromatin organization (GO:0070828)3.23390514
109alpha-linolenic acid metabolic process (GO:0036109)3.23349617
110kynurenine metabolic process (GO:0070189)3.22948593
111biotin metabolic process (GO:0006768)3.19809151
112indole-containing compound catabolic process (GO:0042436)3.19228712
113indolalkylamine catabolic process (GO:0046218)3.19228712
114tryptophan catabolic process (GO:0006569)3.19228712
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.18028585
116cysteine metabolic process (GO:0006534)3.16957447
117glutamine family amino acid biosynthetic process (GO:0009084)3.16616952
118long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.14649265
119maintenance of gastrointestinal epithelium (GO:0030277)3.14622855
120thyroid hormone metabolic process (GO:0042403)3.12614612
121negative regulation of sterol transport (GO:0032372)3.12474260
122negative regulation of cholesterol transport (GO:0032375)3.12474260
123triglyceride metabolic process (GO:0006641)3.12222917
124drug catabolic process (GO:0042737)3.11984035
125fat-soluble vitamin metabolic process (GO:0006775)3.10334457
126cGMP-mediated signaling (GO:0019934)3.09907284
127reverse cholesterol transport (GO:0043691)3.08982527
128sulfate transmembrane transport (GO:1902358)3.07703496
129very long-chain fatty acid metabolic process (GO:0000038)3.07606007
130alditol metabolic process (GO:0019400)3.05789660
131positive regulation of triglyceride metabolic process (GO:0090208)3.05430887
132ethanol metabolic process (GO:0006067)3.05338287
133cholesterol homeostasis (GO:0042632)3.05122677
134phospholipid homeostasis (GO:0055091)3.04969695
135nucleotide-sugar biosynthetic process (GO:0009226)3.04836017
136triglyceride homeostasis (GO:0070328)3.04390713
137acylglycerol homeostasis (GO:0055090)3.04390713
138regulation of telomere maintenance via telomerase (GO:0032210)3.03422555
139valine metabolic process (GO:0006573)3.01997994
140regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01278158
141positive regulation of triglyceride lipase activity (GO:0061365)3.01059341
142positive regulation of lipoprotein lipase activity (GO:0051006)3.01059341
143fatty-acyl-CoA metabolic process (GO:0035337)3.01008866
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00937316
145nitrogen cycle metabolic process (GO:0071941)2.99776320
146glyoxylate metabolic process (GO:0046487)2.99631243
147sterol homeostasis (GO:0055092)2.99589005
148plasma lipoprotein particle organization (GO:0071827)2.99335639
149intestinal epithelial cell development (GO:0060576)2.97860661
150positive regulation of Cdc42 GTPase activity (GO:0043089)2.97834174
151serine family amino acid catabolic process (GO:0009071)2.97759018
152fatty acid derivative transport (GO:1901571)2.96362183
153icosanoid transport (GO:0071715)2.96362183
154lipoprotein metabolic process (GO:0042157)2.95529810
155protein localization to kinetochore (GO:0034501)2.95525171
156nucleoside transport (GO:0015858)2.93716918
157acylglycerol metabolic process (GO:0006639)2.93653872
158thioester biosynthetic process (GO:0035384)2.93126284
159acyl-CoA biosynthetic process (GO:0071616)2.93126284
160regulation of nuclear cell cycle DNA replication (GO:0033262)2.93096078
161tryptophan metabolic process (GO:0006568)2.92920962
162xenobiotic catabolic process (GO:0042178)2.92355921
163plasma lipoprotein particle remodeling (GO:0034369)2.91779280
164protein-lipid complex remodeling (GO:0034368)2.91779280
165macromolecular complex remodeling (GO:0034367)2.91779280
166multicellular organismal water homeostasis (GO:0050891)2.89156531
167neutral lipid metabolic process (GO:0006638)2.88958071
168plasma lipoprotein particle clearance (GO:0034381)2.88416272
169regulation of cholesterol biosynthetic process (GO:0045540)2.87386289
170maternal placenta development (GO:0001893)2.87063254
171histone H4-K5 acetylation (GO:0043981)2.86770035
172response to phenylpropanoid (GO:0080184)2.86010989
173fatty acid homeostasis (GO:0055089)2.84182092
174arginine metabolic process (GO:0006525)2.83451265
175regulation of pseudopodium assembly (GO:0031272)2.83194766
176amino-acid betaine transport (GO:0015838)2.82824415
177carnitine transport (GO:0015879)2.82824415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.94764521
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.33209773
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.33209773
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.33209773
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.63304081
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.56183183
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35607501
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97307881
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.83603489
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.82665146
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.70554726
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.67885005
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66986841
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51620019
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.49905160
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.43621883
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.39632797
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.31524986
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30991417
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.29486215
21ZNF263_19887448_ChIP-Seq_K562_Human2.28541846
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28163820
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26565887
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.23664289
25* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19372198
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18827150
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.14309863
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.11604274
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08372137
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98566854
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93263154
32* SOX2_20726797_ChIP-Seq_SW620_Human1.92138246
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90835672
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85045574
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79605948
36* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.79361781
37* RUNX1_27514584_Chip-Seq_MCF-7_Human1.79224656
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75743134
39CLOCK_20551151_ChIP-Seq_293T_Human1.74288771
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71591105
41NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.69605338
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65600545
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59492103
44VDR_21846776_ChIP-Seq_THP-1_Human1.59265899
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55145070
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54697288
47CTCF_27219007_Chip-Seq_Bcells_Human1.53762882
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.53356642
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50560736
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.49447395
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48277897
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46723188
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42985997
54ATF3_27146783_Chip-Seq_COLON_Human1.42814688
55* KLF5_25053715_ChIP-Seq_YYC3_Human1.42532545
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42302279
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42179331
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41554937
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.39843819
60IRF1_19129219_ChIP-ChIP_H3396_Human1.38071498
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36663701
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34412568
63* BCL6_27268052_Chip-Seq_Bcells_Human1.30398294
64CREB1_26743006_Chip-Seq_LNCaP_Human1.29900335
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29107985
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28844801
67NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27708265
68TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27506357
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27094840
70E2F1_20622854_ChIP-Seq_HELA_Human1.27028087
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.26286521
72SCL_19346495_ChIP-Seq_HPC-7_Human1.26143013
73* TP63_22573176_ChIP-Seq_HFKS_Human1.24981168
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.24889040
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24658595
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24600329
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23223361
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21683061
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21544950
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20377946
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20296073
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20083611
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20063258
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.19991836
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19739820
86NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19678586
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19032526
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18861355
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.18433393
90GATA6_25053715_ChIP-Seq_YYC3_Human1.17181469
91SA1_27219007_Chip-Seq_Bcells_Human1.16575695
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14666007
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13798943
94* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13678746
95POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12953185
96NCOR1_26117541_ChIP-Seq_K562_Human1.12885917
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11130224
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.10165133
99* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09718025
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09561923
101SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06850070
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06812954
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06609320
104NANOG_16518401_ChIP-PET_MESCs_Mouse1.06523596
105LXR_22292898_ChIP-Seq_THP-1_Human1.06429770
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.05807366
107TCF7_22412390_ChIP-Seq_EML_Mouse1.05160541
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03879483
109ETS1_21867929_ChIP-Seq_TH2_Mouse1.03124844
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02974708
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02124724
112VDR_24763502_ChIP-Seq_THP-1_Human1.01893014
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00804325
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.00530704
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99373470
116BCOR_27268052_Chip-Seq_Bcells_Human0.98985477
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.98396983
118* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97902776
119* GATA4_25053715_ChIP-Seq_YYC3_Human0.97206252
120TP53_22127205_ChIP-Seq_IMR90_Human0.96570987
121CTCF_20526341_ChIP-Seq_ESCs_Human0.95663708
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94794772
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92651967
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91624591
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91272943
126E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91091242
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90303114
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90167178
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86884936
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85554979
131SMC4_20622854_ChIP-Seq_HELA_Human0.85506422
132MYC_22102868_ChIP-Seq_BL_Human0.85403331
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82954108
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82151933
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81160249
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80780532
137* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79595612
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77885688
139CTCF_21964334_Chip-Seq_Bcells_Human0.77005440
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74350323
141* HNF4A_19822575_ChIP-Seq_HepG2_Human0.74104363
142P68_20966046_ChIP-Seq_HELA_Human0.73735507
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72218752
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72146976
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71793694
146KAP1_27257070_Chip-Seq_ESCs_Mouse0.70624382
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.70582240
148* RARB_24833708_ChIP-Seq_LIVER_Mouse0.70342131
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.70201748
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69991371
151PHF8_20622854_ChIP-Seq_HELA_Human0.68815433
152* SPI1_26923725_Chip-Seq_HPCs_Mouse0.68794402
153* ESET_19884257_ChIP-Seq_ESCs_Mouse0.68680431
154* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68505719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.38635292
2MP0004264_abnormal_extraembryonic_tissu5.23173532
3MP0002254_reproductive_system_inflammat4.58819016
4MP0002139_abnormal_hepatobiliary_system4.47009846
5MP0003011_delayed_dark_adaptation4.44461007
6MP0005670_abnormal_white_adipose3.76659666
7MP0005085_abnormal_gallbladder_physiolo3.64952239
8MP0008875_abnormal_xenobiotic_pharmacok3.43603998
9MP0005365_abnormal_bile_salt3.29099596
10MP0003705_abnormal_hypodermis_morpholog3.04876354
11MP0005409_darkened_coat_color2.67831120
12MP0005666_abnormal_adipose_tissue2.64295691
13MP0005075_abnormal_melanosome_morpholog2.43987597
14MP0010329_abnormal_lipoprotein_level2.42568083
15MP0003806_abnormal_nucleotide_metabolis2.31688108
16MP0009840_abnormal_foam_cell2.28508080
17MP0003252_abnormal_bile_duct2.26589719
18MP0006292_abnormal_olfactory_placode2.20210691
19MP0001666_abnormal_nutrient_absorption2.14731322
20MP0004185_abnormal_adipocyte_glucose2.05487252
21MP0003183_abnormal_peptide_metabolism2.05441252
22MP0004858_abnormal_nervous_system1.99620244
23MP0002332_abnormal_exercise_endurance1.99503988
24MP0005375_adipose_tissue_phenotype1.95033034
25MP0000566_synostosis1.93734847
26MP0002971_abnormal_brown_adipose1.90460767
27MP0003890_abnormal_embryonic-extraembry1.89654329
28MP0005394_taste/olfaction_phenotype1.87291787
29MP0005499_abnormal_olfactory_system1.87291787
30MP0001664_abnormal_digestion1.79256601
31MP0010352_gastrointestinal_tract_polyps1.75145371
32MP0002796_impaired_skin_barrier1.69409054
33MP0000609_abnormal_liver_physiology1.60279361
34MP0005257_abnormal_intraocular_pressure1.57523358
35MP0004019_abnormal_vitamin_homeostasis1.56860256
36MP0000678_abnormal_parathyroid_gland1.56467312
37MP0003191_abnormal_cellular_cholesterol1.56020937
38MP0005319_abnormal_enzyme/_coenzyme1.51738271
39MP0009379_abnormal_foot_pigmentation1.51648287
40MP0002876_abnormal_thyroid_physiology1.51447742
41MP0004147_increased_porphyrin_level1.51365042
42MP0001765_abnormal_ion_homeostasis1.47854293
43MP0001849_ear_inflammation1.44765190
44MP0005332_abnormal_amino_acid1.43568785
45MP0006035_abnormal_mitochondrial_morpho1.42536409
46MP0005076_abnormal_cell_differentiation1.41916666
47MP0000003_abnormal_adipose_tissue1.41808376
48MP0005451_abnormal_body_composition1.37126190
49MP0004043_abnormal_pH_regulation1.35861740
50MP0001188_hyperpigmentation1.35201816
51MP0003866_abnormal_defecation1.34463937
52MP0001756_abnormal_urination1.30619489
53MP0001764_abnormal_homeostasis1.30353976
54MP0005266_abnormal_metabolism1.28681548
55MP0000538_abnormal_urinary_bladder1.28555614
56MP0002098_abnormal_vibrissa_morphology1.25880694
57MP0006082_CNS_inflammation1.25041885
58MP0008961_abnormal_basal_metabolism1.24815997
59MP0003122_maternal_imprinting1.23863819
60MP0005448_abnormal_energy_balance1.20397275
61MP0004130_abnormal_muscle_cell1.19803908
62MP0002277_abnormal_respiratory_mucosa1.15259916
63MP0005174_abnormal_tail_pigmentation1.13748800
64MP0005636_abnormal_mineral_homeostasis1.11836181
65MP0005334_abnormal_fat_pad1.11237974
66MP0002118_abnormal_lipid_homeostasis1.10818036
67MP0002136_abnormal_kidney_physiology1.10363426
68MP0002132_abnormal_respiratory_system1.10072905
69MP0005023_abnormal_wound_healing1.08525427
70MP0001873_stomach_inflammation1.06366501
71MP0000762_abnormal_tongue_morphology1.01068337
72MP0002909_abnormal_adrenal_gland0.98949736
73MP0010234_abnormal_vibrissa_follicle0.98816969
74MP0000598_abnormal_liver_morphology0.98811566
75MP0003938_abnormal_ear_development0.97660685
76MP0005535_abnormal_body_temperature0.96558537
77MP0004957_abnormal_blastocyst_morpholog0.95820887
78MP0003879_abnormal_hair_cell0.94145075
79MP0004381_abnormal_hair_follicle0.93102903
80MP0002092_abnormal_eye_morphology0.92767974
81MP0001672_abnormal_embryogenesis/_devel0.92590541
82MP0005380_embryogenesis_phenotype0.92590541
83MP0000462_abnormal_digestive_system0.91489803
84MP0000013_abnormal_adipose_tissue0.91049846
85MP0002088_abnormal_embryonic_growth/wei0.90406884
86MP0002653_abnormal_ependyma_morphology0.89951699
87MP0003315_abnormal_perineum_morphology0.89439496
88MP0005248_abnormal_Harderian_gland0.89175539
89MP0005083_abnormal_biliary_tract0.89156206
90MP0009643_abnormal_urine_homeostasis0.88912431
91MP0003868_abnormal_feces_composition0.88431874
92MP0000537_abnormal_urethra_morphology0.87352535
93MP0010368_abnormal_lymphatic_system0.87135892
94MP0002970_abnormal_white_adipose0.84927787
95MP0002127_abnormal_cardiovascular_syste0.84063479
96MP0003984_embryonic_growth_retardation0.83826629
97MP0001243_abnormal_dermal_layer0.82399292
98MP0006138_congestive_heart_failure0.82094641
99MP0003878_abnormal_ear_physiology0.81915265
100MP0005377_hearing/vestibular/ear_phenot0.81915265
101MP0002932_abnormal_joint_morphology0.81635340
102MP0002138_abnormal_hepatobiliary_system0.81564396
103MP0002086_abnormal_extraembryonic_tissu0.79892525
104MP0010771_integument_phenotype0.79047394
105MP0001881_abnormal_mammary_gland0.78910594
106MP0001293_anophthalmia0.77707687
107MP0008057_abnormal_DNA_replication0.77418224
108MP0010030_abnormal_orbit_morphology0.76925935
109MP0002877_abnormal_melanocyte_morpholog0.76563201
110MP0005501_abnormal_skin_physiology0.75780808
111MP0001661_extended_life_span0.75134385
112MP0003453_abnormal_keratinocyte_physiol0.74859161
113MP0002396_abnormal_hematopoietic_system0.74734125
114MP0001663_abnormal_digestive_system0.74206975
115MP0002060_abnormal_skin_morphology0.73490089
116MP0000377_abnormal_hair_follicle0.72664607
117MP0002078_abnormal_glucose_homeostasis0.72662408
118MP0005376_homeostasis/metabolism_phenot0.72299852
119MP0000490_abnormal_crypts_of0.71582248
120MP0005166_decreased_susceptibility_to0.71547323
121MP0003436_decreased_susceptibility_to0.70583050
122MP0009765_abnormal_xenobiotic_induced0.69348077
123MP0005381_digestive/alimentary_phenotyp0.68579148
124MP0001216_abnormal_epidermal_layer0.65849895
125MP0000383_abnormal_hair_follicle0.65456884
126MP0003953_abnormal_hormone_level0.65096893
127MP0003718_maternal_effect0.64872143
128MP0009642_abnormal_blood_homeostasis0.64439143
129MP0003941_abnormal_skin_development0.64293047
130MP0000477_abnormal_intestine_morphology0.62308648
131MP0006036_abnormal_mitochondrial_physio0.60820955
132MP0010678_abnormal_skin_adnexa0.60456785
133MP0009115_abnormal_fat_cell0.60250986
134MP0003186_abnormal_redox_activity0.59140824
135MP0003121_genomic_imprinting0.59025817
136MP0005584_abnormal_enzyme/coenzyme_acti0.58521443
137MP0005058_abnormal_lysosome_morphology0.56255311
138MP0008872_abnormal_physiological_respon0.56176349
139MP0002009_preneoplasia0.55842290
140MP0002233_abnormal_nose_morphology0.55245559
141MP0000467_abnormal_esophagus_morphology0.55224447
142MP0010155_abnormal_intestine_physiology0.55182758
143MP0004947_skin_inflammation0.55122865
144MP0000470_abnormal_stomach_morphology0.54552144
145MP0000230_abnormal_systemic_arterial0.54452024
146MP0004782_abnormal_surfactant_physiolog0.53823880
147MP0008770_decreased_survivor_rate0.53687688
148MP0009763_increased_sensitivity_to0.52682053
149MP0009931_abnormal_skin_appearance0.51980873
150MP0002269_muscular_atrophy0.50102473
151MP0008789_abnormal_olfactory_epithelium0.50000257
152MP0000647_abnormal_sebaceous_gland0.49767218
153MP0009764_decreased_sensitivity_to0.48844057

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.26346953
2Bilateral microphthalmos (HP:0007633)5.99424268
3Hemorrhage of the eye (HP:0011885)5.06750965
4Hepatoblastoma (HP:0002884)4.90975214
5Hydroxyprolinuria (HP:0003080)4.80915915
6Abnormality of proline metabolism (HP:0010907)4.80915915
7Widely patent fontanelles and sutures (HP:0004492)4.42790926
8Abnormality of the lower motor neuron (HP:0002366)4.38352766
9Multiple enchondromatosis (HP:0005701)4.34414188
10Hyperactive renin-angiotensin system (HP:0000841)4.30145388
11Ileus (HP:0002595)4.11640830
12Right ventricular cardiomyopathy (HP:0011663)4.07845205
13Decreased circulating renin level (HP:0003351)3.99363710
14Thin bony cortex (HP:0002753)3.96691333
15Intrahepatic cholestasis (HP:0001406)3.88217996
16Ependymoma (HP:0002888)3.86795020
17Hyperinsulinemic hypoglycemia (HP:0000825)3.77724810
18Malnutrition (HP:0004395)3.70941891
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67422811
20Abnormality of the intrinsic pathway (HP:0010989)3.55987339
21Rib fusion (HP:0000902)3.54008553
22Hyperglycinuria (HP:0003108)3.50845217
23Xanthomatosis (HP:0000991)3.48522427
24Pigmentary retinal degeneration (HP:0001146)3.44635719
25Abnormality of renin-angiotensin system (HP:0000847)3.40731927
26Hypobetalipoproteinemia (HP:0003563)3.37432824
27Abnormal cartilage morphology (HP:0002763)3.36503915
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32334721
29Abnormality of the vitamin B12 metabolism (HP:0004341)3.18485930
30Abnormality of the salivary glands (HP:0010286)3.15178730
31Deep venous thrombosis (HP:0002625)3.14395165
32Wide cranial sutures (HP:0010537)3.11067124
33Rhabdomyosarcoma (HP:0002859)3.09855122
34Confusion (HP:0001289)3.05711268
35Neoplasm of striated muscle (HP:0009728)3.01177343
36Abnormality of vitamin B metabolism (HP:0004340)2.94784708
37Skin nodule (HP:0200036)2.94333339
38Delayed epiphyseal ossification (HP:0002663)2.92803460
39Increased connective tissue (HP:0009025)2.88068898
40Ragged-red muscle fibers (HP:0003200)2.87540248
41Pili torti (HP:0003777)2.86632961
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86503303
43Flat acetabular roof (HP:0003180)2.83601329
44Abnormality of vitamin metabolism (HP:0100508)2.83264115
45Abdominal distention (HP:0003270)2.81725691
46Popliteal pterygium (HP:0009756)2.76841320
47Partial duplication of thumb phalanx (HP:0009944)2.75896682
48Abnormality of glycine metabolism (HP:0010895)2.71937472
49Abnormality of serine family amino acid metabolism (HP:0010894)2.71937472
50Metabolic alkalosis (HP:0200114)2.70358274
51Reduced antithrombin III activity (HP:0001976)2.69692772
52Glycosuria (HP:0003076)2.69598924
53Abnormality of urine glucose concentration (HP:0011016)2.69598924
54Microretrognathia (HP:0000308)2.68911969
55Alkalosis (HP:0001948)2.64248005
56Abnormality of the astrocytes (HP:0100707)2.64137243
57Astrocytoma (HP:0009592)2.64137243
58Acanthocytosis (HP:0001927)2.59327277
59Nausea (HP:0002018)2.58582041
60Hypertriglyceridemia (HP:0002155)2.56468124
61Hypolipoproteinemia (HP:0010981)2.56039683
62Hypochromic anemia (HP:0001931)2.55884390
63Testicular atrophy (HP:0000029)2.55672006
64Abnormality of the costochondral junction (HP:0000919)2.54111489
65Acanthosis nigricans (HP:0000956)2.52882497
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.49980350
67Hypoplasia of the fovea (HP:0007750)2.49980350
68Bifid tongue (HP:0010297)2.45972778
69Chronic diarrhea (HP:0002028)2.45840833
70Anomalous pulmonary venous return (HP:0010772)2.45656903
71Hyperammonemia (HP:0001987)2.45435877
72Gout (HP:0001997)2.42624447
73Vaginal fistula (HP:0004320)2.40073417
74Pseudobulbar signs (HP:0002200)2.39737793
75Epidermoid cyst (HP:0200040)2.38074376
76Upper motor neuron abnormality (HP:0002127)2.37500840
77Abnormal hair laboratory examination (HP:0003328)2.36632057
78Partial duplication of the phalanx of hand (HP:0009999)2.36020975
79Enlarged epiphyses (HP:0010580)2.35720606
80Hypercholesterolemia (HP:0003124)2.34231443
81Abnormality of chloride homeostasis (HP:0011422)2.33834140
82Fused cervical vertebrae (HP:0002949)2.32895423
83Facial shape deformation (HP:0011334)2.32725043
84Potter facies (HP:0002009)2.32725043
85Megaloblastic anemia (HP:0001889)2.32408731
86Focal segmental glomerulosclerosis (HP:0000097)2.32224217
87Prolonged partial thromboplastin time (HP:0003645)2.30984997
88Akinesia (HP:0002304)2.30703671
89Proximal tubulopathy (HP:0000114)2.29380958
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28771631
91Dicarboxylic aciduria (HP:0003215)2.28771631
92Abnormality of small intestinal villus morphology (HP:0011472)2.28556002
93Villous atrophy (HP:0011473)2.28556002
94Subcapsular cataract (HP:0000523)2.28227148
95Fat malabsorption (HP:0002630)2.28191909
96Neonatal onset (HP:0003623)2.28118616
97Hypophosphatemic rickets (HP:0004912)2.26677727
98Abnormal urine phosphate concentration (HP:0012599)2.25149567
99Hand muscle atrophy (HP:0009130)2.25082835
100Rectovaginal fistula (HP:0000143)2.25004337
101Rectal fistula (HP:0100590)2.25004337
102Hyponatremia (HP:0002902)2.24040795
103Abnormal albumin level (HP:0012116)2.22751535
104Hypoalbuminemia (HP:0003073)2.22751535
105Tetraplegia (HP:0002445)2.20237750
106Systemic lupus erythematosus (HP:0002725)2.19938855
107Joint hemorrhage (HP:0005261)2.19809873
108Peritonitis (HP:0002586)2.19309535
109Steatorrhea (HP:0002570)2.18843938
110Hypoalphalipoproteinemia (HP:0003233)2.18467999
111Hyperuricemia (HP:0002149)2.12292703
112Increased purine levels (HP:0004368)2.12292703
113Nephroblastoma (Wilms tumor) (HP:0002667)2.11637413
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11442544
115Curly hair (HP:0002212)2.11048431
116Alopecia of scalp (HP:0002293)2.09550720
117Congenital sensorineural hearing impairment (HP:0008527)2.06460523
118Abnormality of the pulmonary veins (HP:0011718)2.06123643
119Short humerus (HP:0005792)2.05679633
120Nephrolithiasis (HP:0000787)2.05673595
121Cheilitis (HP:0100825)2.05472055
122Abnormality of sulfur amino acid metabolism (HP:0004339)2.04698979
123Complement deficiency (HP:0004431)2.04140021
124Intestinal fistula (HP:0100819)2.03024371
125Hyperventilation (HP:0002883)2.02883939
126Pterygium (HP:0001059)2.02676037
127Preauricular pit (HP:0004467)2.02590224
128Periauricular skin pits (HP:0100277)2.02590224
129Hypophosphatemia (HP:0002148)2.01039995
130Glomerulosclerosis (HP:0000096)2.00244535
131Trismus (HP:0000211)1.99650190
132Aplasia/hypoplasia of the humerus (HP:0006507)1.99281432
133Short 5th finger (HP:0009237)1.99098709
134Rickets (HP:0002748)1.98283412
135Renal tubular dysfunction (HP:0000124)1.97342433
136Skin pits (HP:0100276)1.92917749
137Ketosis (HP:0001946)1.92876080
138Bronchomalacia (HP:0002780)1.92153219
139Hyperaldosteronism (HP:0000859)1.91308247
140Embryonal renal neoplasm (HP:0011794)1.90802678
141Late onset (HP:0003584)1.90396122
142Growth hormone excess (HP:0000845)1.90206199
143Hypotension (HP:0002615)1.90052049
144Gastrointestinal dysmotility (HP:0002579)1.88538544
145Hyperphosphaturia (HP:0003109)1.87971896
146Pancreatic islet-cell hyperplasia (HP:0004510)1.87896551
147Amyloidosis (HP:0011034)1.87667129
148Preauricular skin tag (HP:0000384)1.86879367
149Ulnar bowing (HP:0003031)1.85757654
150Shawl scrotum (HP:0000049)1.85150494
151Insulin resistance (HP:0000855)1.85130312
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85121997
153Increased muscle lipid content (HP:0009058)1.84352636
154Coronal craniosynostosis (HP:0004440)1.84283155
155Large earlobe (HP:0009748)1.83723564
156Hyperparathyroidism (HP:0000843)1.83444654
157Aplasia/Hypoplasia of the macula (HP:0008059)1.83422124
158Abnormality of the Achilles tendon (HP:0005109)1.83209159
159Metabolic acidosis (HP:0001942)1.82506349
160Abnormality of nucleobase metabolism (HP:0010932)1.82349298
161Amyotrophic lateral sclerosis (HP:0007354)1.81254851
162Hyperlipoproteinemia (HP:0010980)1.80916177
163Abnormality of the musculature of the hand (HP:0001421)1.80897439
164Abnormal tarsal ossification (HP:0008369)1.80800543
165Horizontal nystagmus (HP:0000666)1.79903927
166Conjugated hyperbilirubinemia (HP:0002908)1.79866765
167Glioma (HP:0009733)1.78990829
168Neoplasm of the oral cavity (HP:0100649)1.78486381
169Hypoplastic scapulae (HP:0000882)1.78096129
170Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78096129
171Hyperglycinemia (HP:0002154)1.77322044
172Upper limb amyotrophy (HP:0009129)1.75565435
173Distal upper limb amyotrophy (HP:0007149)1.75565435
174Abnormality of purine metabolism (HP:0004352)1.75474301
175Abnormality of the distal phalanx of the thumb (HP:0009617)1.74557642
176Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74529578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.97162223
2ERN15.47827747
3GRK54.36841994
4GRK64.31624130
5ACVR1B3.91328698
6GRK13.25329813
7STK102.91098934
8TGFBR22.71447238
9MATK2.67548871
10MAPK152.66595631
11ADRBK22.55504868
12LMTK22.51126095
13CSF1R2.45981021
14MAP2K42.17950223
15MAPK72.16529270
16EPHA22.13839554
17MAP2K62.09140863
18STK392.08557643
19MAP2K31.97641239
20TTK1.85329731
21GRK71.84409077
22EPHB21.80976898
23TYRO31.80963569
24WNK41.78329568
25MAP3K61.71357456
26PRKG21.69467833
27MOS1.48187585
28TESK21.44760745
29PIK3CA1.44686062
30PDK21.44170891
31MAP3K101.40398744
32MAP3K21.39206230
33SIK11.35633312
34MAP3K71.33323146
35RIPK11.30056150
36CAMK41.27963390
37MARK21.25470854
38TIE11.22342485
39AKT31.19480255
40OXSR11.17081191
41NTRK11.13199111
42WNK11.13070605
43PDPK11.11221485
44PAK41.10626634
45EPHB11.08725318
46NME11.08669574
47BCKDK1.07641715
48ADRBK11.07221038
49SMG11.06552320
50CDK71.05339458
51STK241.03908984
52MST1R1.01901627
53FGFR30.99969146
54PBK0.98409477
55FER0.96894832
56TESK10.96724264
57CSK0.85990209
58IRAK30.85887035
59MUSK0.84331783
60HIPK20.83633812
61PTK20.83293948
62BMX0.77529465
63TNIK0.73522155
64NLK0.69965059
65CDK60.69287048
66TLK10.67883565
67MAP3K10.66919101
68EEF2K0.66135359
69CHEK20.65834287
70IRAK20.64746211
71TRIB30.64318053
72LATS10.63851854
73PRKCI0.63451498
74FGFR40.63149660
75ERBB20.63024951
76MAPK120.62065152
77MAP3K30.61006909
78CDC42BPA0.59837215
79AKT20.59325763
80STK38L0.58898196
81MYLK0.58200066
82MST40.57282866
83LATS20.54738703
84MAP3K120.54643216
85EPHA30.52511722
86RPS6KB20.52310601
87MTOR0.52293705
88IGF1R0.51456844
89PRKD20.51375814
90MAP2K10.48873189
91TAOK10.48193378
92FRK0.47921095
93MAP2K20.47306046
94IRAK10.47062228
95MAPK40.46995083
96PTK60.45714289
97EIF2AK20.43298487
98IKBKB0.43247610
99ABL20.41259755
100MELK0.40692143
101STK30.40007982
102ALK0.39833669
103KIT0.39765001
104ERBB40.39303619
105CAMK1D0.38897351
106NEK60.38594341
107MET0.38401517
108STK380.36648418
109PRKAA20.34907485
110PDK10.34416324
111ITK0.34392981
112PRKCD0.33433203
113FLT30.33086906
114TBK10.32708772
115SRC0.30996621
116BLK0.30435248
117ZAP700.30076619
118PKN20.29795216
119YES10.29376550
120PIK3CG0.27927218
121PRKAA10.27220182
122INSRR0.26658187
123PRKACG0.25866259
124RET0.24608102
125GSK3A0.24482552
126PRKCZ0.24478700
127JAK20.24128866
128ICK0.24086594
129TAOK30.23735424
130PDGFRA0.23554820
131MAP3K110.22983514
132TYK20.22471301
133ZAK0.21515191
134CHUK0.21511414
135DYRK1B0.21463065
136INSR0.21301910
137DDR20.21063962
138LRRK20.19780339
139PRKCA0.19372616
140CHEK10.19161592
141RPS6KA20.19120337
142MAP3K50.18962450
143MAPK110.18637755
144CAMK2D0.18547242
145CSNK1A10.17999310
146MAPK10.17969722
147PAK30.17574468
148* PLK10.15713525
149TAOK20.13258074
150CDK40.13013023
151ABL10.12334188
152MAPKAPK30.12294221
153MARK30.12071421

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.46763624
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.95687298
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.95338533
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.93832050
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.83523964
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78037453
7Tryptophan metabolism_Homo sapiens_hsa003802.53021462
8Fructose and mannose metabolism_Homo sapiens_hsa000512.46002523
9Galactose metabolism_Homo sapiens_hsa000522.28709787
10Arginine biosynthesis_Homo sapiens_hsa002202.28405186
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22488223
12Complement and coagulation cascades_Homo sapiens_hsa046102.14801090
13Nitrogen metabolism_Homo sapiens_hsa009102.10650724
14Chemical carcinogenesis_Homo sapiens_hsa052042.09216087
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06247997
16Fat digestion and absorption_Homo sapiens_hsa049752.05715806
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96092110
18Caffeine metabolism_Homo sapiens_hsa002321.94336535
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86821675
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85428777
21PPAR signaling pathway_Homo sapiens_hsa033201.82861635
22Fatty acid degradation_Homo sapiens_hsa000711.77310636
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74146677
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.70943238
25Histidine metabolism_Homo sapiens_hsa003401.70008850
26Bile secretion_Homo sapiens_hsa049761.68266363
27Folate biosynthesis_Homo sapiens_hsa007901.67807356
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66724870
29Starch and sucrose metabolism_Homo sapiens_hsa005001.64020747
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62543411
31Retinol metabolism_Homo sapiens_hsa008301.57090341
32Arachidonic acid metabolism_Homo sapiens_hsa005901.46412613
33Peroxisome_Homo sapiens_hsa041461.45497176
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43239858
35Vitamin digestion and absorption_Homo sapiens_hsa049771.40759338
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38811003
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.37620800
38Linoleic acid metabolism_Homo sapiens_hsa005911.37618847
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.37129352
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25376013
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.20248261
42Butanoate metabolism_Homo sapiens_hsa006501.19237799
43beta-Alanine metabolism_Homo sapiens_hsa004101.18463349
44Sphingolipid metabolism_Homo sapiens_hsa006001.17184416
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10370787
46Selenocompound metabolism_Homo sapiens_hsa004501.09607324
47ABC transporters_Homo sapiens_hsa020101.08879408
48Carbon metabolism_Homo sapiens_hsa012001.07292048
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06971238
50Phenylalanine metabolism_Homo sapiens_hsa003601.04148515
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03877138
52Biosynthesis of amino acids_Homo sapiens_hsa012301.03066105
53Sulfur metabolism_Homo sapiens_hsa009201.01871595
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00436848
55Fatty acid metabolism_Homo sapiens_hsa012121.00182432
56Tyrosine metabolism_Homo sapiens_hsa003500.96210396
57Sulfur relay system_Homo sapiens_hsa041220.92750654
58Staphylococcus aureus infection_Homo sapiens_hsa051500.88266068
59Pentose phosphate pathway_Homo sapiens_hsa000300.83829386
60Lysine degradation_Homo sapiens_hsa003100.83358145
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81290141
62Glycerolipid metabolism_Homo sapiens_hsa005610.80703926
63Renin-angiotensin system_Homo sapiens_hsa046140.79159516
64Propanoate metabolism_Homo sapiens_hsa006400.75001475
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70249881
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67019664
67Pyruvate metabolism_Homo sapiens_hsa006200.65890662
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65877866
69Glutathione metabolism_Homo sapiens_hsa004800.64696811
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.64344288
71Arginine and proline metabolism_Homo sapiens_hsa003300.63109452
72Tight junction_Homo sapiens_hsa045300.62005500
73Steroid biosynthesis_Homo sapiens_hsa001000.58946013
74Ovarian steroidogenesis_Homo sapiens_hsa049130.56773274
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55747891
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.55644704
77One carbon pool by folate_Homo sapiens_hsa006700.53802393
78Protein digestion and absorption_Homo sapiens_hsa049740.53163175
79Thyroid cancer_Homo sapiens_hsa052160.52988130
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51086503
81Mineral absorption_Homo sapiens_hsa049780.49304841
82Fatty acid elongation_Homo sapiens_hsa000620.48414632
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46041033
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44545253
85Pancreatic secretion_Homo sapiens_hsa049720.43268996
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43112881
87Metabolic pathways_Homo sapiens_hsa011000.38220368
88Glucagon signaling pathway_Homo sapiens_hsa049220.37641529
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37439947
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.34829308
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33336808
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31544544
93Ether lipid metabolism_Homo sapiens_hsa005650.30597062
94Insulin signaling pathway_Homo sapiens_hsa049100.30576178
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.30548117
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28755271
97Inositol phosphate metabolism_Homo sapiens_hsa005620.28686973
98Insulin resistance_Homo sapiens_hsa049310.25773111
99mTOR signaling pathway_Homo sapiens_hsa041500.25769014
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25768140
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.24130447
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.24021600
103African trypanosomiasis_Homo sapiens_hsa051430.23702410
104Bladder cancer_Homo sapiens_hsa052190.23449979
105Other glycan degradation_Homo sapiens_hsa005110.23022006
106Fatty acid biosynthesis_Homo sapiens_hsa000610.22535182
107Acute myeloid leukemia_Homo sapiens_hsa052210.20012049
108Hepatitis C_Homo sapiens_hsa051600.19150459
109Thyroid hormone synthesis_Homo sapiens_hsa049180.18246354
110AMPK signaling pathway_Homo sapiens_hsa041520.16154947
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13626327
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13071747
113N-Glycan biosynthesis_Homo sapiens_hsa005100.12520872
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12215102
115Choline metabolism in cancer_Homo sapiens_hsa052310.11658517
116Renin secretion_Homo sapiens_hsa049240.09601937

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