PLEKHB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.43110521
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28720016
3synaptic vesicle exocytosis (GO:0016079)5.20054406
4synaptic vesicle maturation (GO:0016188)5.19376276
5glycolipid catabolic process (GO:0019377)5.02791778
6regulation of synaptic vesicle exocytosis (GO:2000300)4.85747085
7protein localization to endosome (GO:0036010)4.75563685
8oligosaccharide catabolic process (GO:0009313)4.74016849
9vocalization behavior (GO:0071625)4.59227577
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.55608565
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54773863
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54112538
13glutamate secretion (GO:0014047)4.50034013
14locomotory exploration behavior (GO:0035641)4.49017227
15cellular potassium ion homeostasis (GO:0030007)4.37150898
16ceramide catabolic process (GO:0046514)4.33797248
17regulation of synaptic vesicle transport (GO:1902803)4.31092477
18COPI coating of Golgi vesicle (GO:0048205)4.22543433
19Golgi transport vesicle coating (GO:0048200)4.22543433
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22402019
21neurotransmitter secretion (GO:0007269)4.17774343
22cellular response to thyroid hormone stimulus (GO:0097067)4.17040773
23membrane lipid catabolic process (GO:0046466)4.15513394
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13897594
25regulation of early endosome to late endosome transport (GO:2000641)4.10178647
26phagosome maturation (GO:0090382)4.10021078
27regulation of glutamate receptor signaling pathway (GO:1900449)4.09762098
28sphingolipid catabolic process (GO:0030149)4.07902542
29protein localization to synapse (GO:0035418)4.01667370
30sodium ion export (GO:0071436)3.98614615
31neurotransmitter-gated ion channel clustering (GO:0072578)3.90468096
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86284983
33amino sugar catabolic process (GO:0046348)3.68096291
34neuronal action potential propagation (GO:0019227)3.64481149
35proline transport (GO:0015824)3.62051019
36regulation of synapse structural plasticity (GO:0051823)3.57496021
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.54868450
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53913609
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53781906
40barbed-end actin filament capping (GO:0051016)3.52264317
41neurotransmitter transport (GO:0006836)3.49355000
42eosinophil chemotaxis (GO:0048245)3.48337118
43neuron cell-cell adhesion (GO:0007158)3.47963642
44cellular copper ion homeostasis (GO:0006878)3.44383022
45response to thyroid hormone (GO:0097066)3.42555237
46exploration behavior (GO:0035640)3.37422241
47neuron-neuron synaptic transmission (GO:0007270)3.36958991
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.35934316
49activation of protein kinase A activity (GO:0034199)3.35619788
50gamma-aminobutyric acid transport (GO:0015812)3.30885178
51iron ion transport (GO:0006826)3.28493358
52glutamate receptor signaling pathway (GO:0007215)3.28452892
53regulation of neuronal synaptic plasticity (GO:0048168)3.26782105
54synaptic transmission, glutamatergic (GO:0035249)3.26347856
55positive regulation of leukocyte degranulation (GO:0043302)3.25074556
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23720903
57layer formation in cerebral cortex (GO:0021819)3.22820749
58negative regulation of protein localization to plasma membrane (GO:1903077)3.22699885
59response to histamine (GO:0034776)3.21643268
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21583054
61positive regulation of membrane potential (GO:0045838)3.21232094
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20111018
63intracellular pH reduction (GO:0051452)3.19327869
64pH reduction (GO:0045851)3.19170677
65regulation of neurotransmitter secretion (GO:0046928)3.16462826
66positive regulation of receptor recycling (GO:0001921)3.16421686
67long-term synaptic potentiation (GO:0060291)3.16325283
68long-term memory (GO:0007616)3.15063154
69cell communication by electrical coupling (GO:0010644)3.14405190
70fat-soluble vitamin biosynthetic process (GO:0042362)3.13155995
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11666858
72synaptic vesicle endocytosis (GO:0048488)3.10640559
73ganglioside metabolic process (GO:0001573)3.10450316
74neuromuscular process controlling posture (GO:0050884)3.08708619
75positive regulation of synapse maturation (GO:0090129)3.08612556
76eosinophil migration (GO:0072677)3.08248189
77regulation of neurotransmitter levels (GO:0001505)3.07886783
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07314247
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.04586877
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03888189
81potassium ion homeostasis (GO:0055075)3.02468454
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02184358
83cerebellar Purkinje cell differentiation (GO:0021702)3.01263177
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00373674
85ATP hydrolysis coupled proton transport (GO:0015991)3.00373674
86transferrin transport (GO:0033572)2.98019307
87amino acid import (GO:0043090)2.96906243
88regulation of cellular pH (GO:0030641)2.96790331
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95580368
90regulation of vesicle fusion (GO:0031338)2.95458648
91regulation of neurotransmitter transport (GO:0051588)2.94870737
92regulation of voltage-gated calcium channel activity (GO:1901385)2.94817112
93membrane depolarization during action potential (GO:0086010)2.94807469
94regulation of intracellular pH (GO:0051453)2.94769885
95regulation of postsynaptic membrane potential (GO:0060078)2.93796789
96positive regulation of neurotransmitter transport (GO:0051590)2.93691544
97response to auditory stimulus (GO:0010996)2.93480605
98positive regulation of regulated secretory pathway (GO:1903307)2.90381114
99regulation of clathrin-mediated endocytosis (GO:2000369)2.90082228
100membrane hyperpolarization (GO:0060081)2.89502043
101cellular response to arsenic-containing substance (GO:0071243)2.89220232
102potassium ion import (GO:0010107)2.88709426
103regulation of synaptic plasticity (GO:0048167)2.85383927
104regulation of mononuclear cell migration (GO:0071675)2.84274759
105regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.83464567
106striatum development (GO:0021756)2.82422300
107vesicle transport along microtubule (GO:0047496)2.82349929
108N-acetylneuraminate metabolic process (GO:0006054)2.81371711
109regulation of podosome assembly (GO:0071801)2.81211499
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.79711622
111osteoclast differentiation (GO:0030316)2.79548743
112response to lipoprotein particle (GO:0055094)2.79397190
113trivalent inorganic cation transport (GO:0072512)2.77871614
114ferric iron transport (GO:0015682)2.77871614
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77556205
116cellular iron ion homeostasis (GO:0006879)2.75974162
117positive regulation of synaptic transmission (GO:0050806)2.75960195
118mating behavior (GO:0007617)2.73851361
119glycine transport (GO:0015816)2.70492533
120positive regulation of cellular amide metabolic process (GO:0034250)2.70052266
121synaptic transmission (GO:0007268)2.69970931
122glucose 6-phosphate metabolic process (GO:0051156)2.69627158
123membrane depolarization (GO:0051899)2.68939258
124cellular transition metal ion homeostasis (GO:0046916)2.68581168
125membrane repolarization (GO:0086009)2.67759061
126vesicle coating (GO:0006901)2.67753699
127postsynaptic membrane organization (GO:0001941)2.66337303
128regulation of superoxide anion generation (GO:0032928)2.66129260
129serine transport (GO:0032329)2.66052915
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65559407
131positive regulation of neurotransmitter secretion (GO:0001956)2.65050904
132neuromuscular process controlling balance (GO:0050885)2.64835885
133positive regulation of monocyte chemotaxis (GO:0090026)2.64159194
134cellular sodium ion homeostasis (GO:0006883)2.62828714
135angiotensin maturation (GO:0002003)2.62394084
136cell adhesion mediated by integrin (GO:0033627)2.62124079
137vitamin D metabolic process (GO:0042359)2.60938488
138apoptotic cell clearance (GO:0043277)2.60803484
139prepulse inhibition (GO:0060134)2.60179379
140stress fiber assembly (GO:0043149)2.57287673
141adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56958883
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56952687
143regulation of synaptic transmission, GABAergic (GO:0032228)2.56176752
144long term synaptic depression (GO:0060292)2.56163067
145establishment of synaptic vesicle localization (GO:0097480)2.56157401
146synaptic vesicle transport (GO:0048489)2.56157401
147regulation of regulated secretory pathway (GO:1903305)2.55802111
148synapse assembly (GO:0007416)2.55623024
149regulation of synaptic transmission (GO:0050804)2.55544886
150regulation of female receptivity (GO:0045924)2.54891502
151negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54854706
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54753303
153regulation of ARF protein signal transduction (GO:0032012)2.53985979
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53850069
155sphingosine metabolic process (GO:0006670)2.53238960
156regulation of receptor recycling (GO:0001919)2.51337394
157copper ion homeostasis (GO:0055070)2.49751379
158regulation of vitamin D biosynthetic process (GO:0060556)2.47474100
159neutrophil activation involved in immune response (GO:0002283)2.43159868
160negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.42977823
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42387661
162L-serine transport (GO:0015825)2.42374949
163glycosphingolipid metabolic process (GO:0006687)2.42276690
164glucosamine-containing compound catabolic process (GO:1901072)2.40345518
165decidualization (GO:0046697)2.38791454
166regulation of leukocyte degranulation (GO:0043300)2.38726136
167fructose metabolic process (GO:0006000)2.38493772
168negative regulation of interleukin-17 production (GO:0032700)2.38299433
169response to peptidoglycan (GO:0032494)2.37422655
170positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33363740
171negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.33000938
172cellular monovalent inorganic cation homeostasis (GO:0030004)2.31825416
173negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30904885
174COPII vesicle coating (GO:0048208)2.30711462
175endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.30677439
176regulation of cholesterol storage (GO:0010885)2.28309723
177response to acidic pH (GO:0010447)2.26482884
178regulation of cellular amide metabolic process (GO:0034248)2.25871414
179transition metal ion transport (GO:0000041)2.25829487
180peptide catabolic process (GO:0043171)2.25628305
181positive regulation of macroautophagy (GO:0016239)2.25559268
182virion attachment to host cell (GO:0019062)2.25348303
183adhesion of symbiont to host cell (GO:0044650)2.25348303
184lytic vacuole organization (GO:0080171)2.25306337
185lysosome organization (GO:0007040)2.25306337
186adenosine receptor signaling pathway (GO:0001973)2.24569694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.10703245
2Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.86279817
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.64260867
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.49869483
5NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34266549
6GBX2_23144817_ChIP-Seq_PC3_Human3.29840632
7TFEB_21752829_ChIP-Seq_HELA_Human3.03822908
8SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.97781284
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96785634
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95025372
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91294700
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.89653198
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88789463
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83885475
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76898762
16CLOCK_20551151_ChIP-Seq_293T_Human2.57486990
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51277112
18DROSHA_22980978_ChIP-Seq_HELA_Human2.47579666
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.44500279
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44434995
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39948067
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37915194
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35521457
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.34571943
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34291491
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34291491
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32641041
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31042828
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27590951
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26658230
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23017849
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14622431
33* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08924162
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.06176525
35SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04746286
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.99978861
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98733693
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.93016262
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.87453694
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.84639303
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.81835127
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.76319096
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.74952852
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72680488
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72649853
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72554399
47SOX2_20726797_ChIP-Seq_SW620_Human1.68386668
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67381529
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.67287583
50EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.63855113
51SMAD4_21799915_ChIP-Seq_A2780_Human1.63611544
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61949069
53* ESR1_21235772_ChIP-Seq_MCF-7_Human1.56325535
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55565009
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55127997
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52599234
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52421338
58AR_21572438_ChIP-Seq_LNCaP_Human1.52384813
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51822671
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51712760
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50768350
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49769681
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47860146
64GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.47618297
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43665263
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42505223
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38018775
68TAF15_26573619_Chip-Seq_HEK293_Human1.37503828
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37421372
70VDR_24787735_ChIP-Seq_THP-1_Human1.37072975
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36854618
72* PU_27001747_Chip-Seq_BMDM_Mouse1.33462434
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33239903
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33205265
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33205265
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31742059
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31714116
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29921347
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29476390
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29308050
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28335415
82AR_25329375_ChIP-Seq_VCAP_Human1.27448545
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27062921
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26985624
85* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26561932
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26236763
87SPI1_23547873_ChIP-Seq_NB4_Human1.24725717
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.24624221
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24324337
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24049798
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.23589434
92P300_19829295_ChIP-Seq_ESCs_Human1.22720175
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21921804
94SPI1_23127762_ChIP-Seq_K562_Human1.16887703
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15867238
96ZNF263_19887448_ChIP-Seq_K562_Human1.15277156
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14931344
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14062094
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13910041
100* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13795240
101* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13770042
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13089571
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.11797296
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.11544409
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10945028
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10779195
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09812288
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09644023
109AR_19668381_ChIP-Seq_PC3_Human1.09619464
110STAT3_23295773_ChIP-Seq_U87_Human1.09340127
111AHR_22903824_ChIP-Seq_MCF-7_Human1.08630400
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07868319
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07779386
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07139438
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.06896289
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.06737237
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05953510
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05846097
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.05817053
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04709789
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04670736
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04616700
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04163602
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.03793483
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01692009
126RUNX1_22412390_ChIP-Seq_EML_Mouse1.00933188
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00917133
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00355460
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00316948
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99863504
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99469314
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99438510
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99389098
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99148774
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99142159
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.98644395
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.98146412
138* RING1B_27294783_Chip-Seq_ESCs_Mouse0.97565878
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97339192
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97275719
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96667288
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96459928
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96390010
144* DCP1A_22483619_ChIP-Seq_HELA_Human0.95226549
145TCF4_23295773_ChIP-Seq_U87_Human0.95191349
146KDM2B_26808549_Chip-Seq_K562_Human0.95095613
147RXR_22108803_ChIP-Seq_LS180_Human0.94440328
148ZNF274_21170338_ChIP-Seq_K562_Hela0.94348655
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94067949
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.92875560
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92617349
152* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92347791
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92299497
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92150785
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91891829
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91792854
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90630047
158PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90556714
159ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90473604
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90281307
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90209934
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.89838099
163PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89746800
164IGF1R_20145208_ChIP-Seq_DFB_Human0.89569214
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89547792
166STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89096263
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.88418647
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87678498
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86531069
170CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86023323
171POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85670329
172ER_23166858_ChIP-Seq_MCF-7_Human0.85243517
173NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84719758
174CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84600481
175RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84421249
176RUNX2_22187159_ChIP-Seq_PCA_Human0.84421227
177CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84334646
178SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83845484
179VDR_22108803_ChIP-Seq_LS180_Human0.83372505
180* MITF_21258399_ChIP-Seq_MELANOMA_Human0.82630553
181REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82363513
182SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82029450
183NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81908142
184BCAT_22108803_ChIP-Seq_LS180_Human0.80787182
185RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80041616
186UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78888748
187NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78586957
188NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78586957
189EP300_21415370_ChIP-Seq_HL-1_Mouse0.77517908
190RNF2_27304074_Chip-Seq_NSC_Mouse0.77291231
191CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76898928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.38108046
2MP0009840_abnormal_foam_cell4.06067438
3MP0003880_abnormal_central_pattern4.01108822
4MP0003635_abnormal_synaptic_transmissio3.69029918
5MP0002822_catalepsy3.45798453
6MP0009046_muscle_twitch3.24952293
7MP0004270_analgesia3.20757958
8MP0009745_abnormal_behavioral_response3.14994744
9MP0001968_abnormal_touch/_nociception3.08209677
10MP0002064_seizures3.06770617
11MP0002063_abnormal_learning/memory/cond2.90976679
12MP0003191_abnormal_cellular_cholesterol2.86538622
13MP0006082_CNS_inflammation2.80676960
14MP0008260_abnormal_autophagy2.65561647
15MP0002877_abnormal_melanocyte_morpholog2.65493444
16MP0002734_abnormal_mechanical_nocicepti2.57618125
17MP0002736_abnormal_nociception_after2.57246747
18MP0005423_abnormal_somatic_nervous2.55179724
19MP0002572_abnormal_emotion/affect_behav2.49970789
20MP0002272_abnormal_nervous_system2.38833972
21MP0003806_abnormal_nucleotide_metabolis2.35765770
22MP0005451_abnormal_body_composition2.34504916
23MP0002735_abnormal_chemical_nociception2.33374389
24MP0001501_abnormal_sleep_pattern2.28278317
25MP0000343_altered_response_to2.10200652
26MP0001486_abnormal_startle_reflex2.05906442
27MP0000015_abnormal_ear_pigmentation2.02559013
28MP0002909_abnormal_adrenal_gland2.00316957
29MP0001970_abnormal_pain_threshold1.99524661
30MP0009780_abnormal_chondrocyte_physiolo1.98673144
31MP0001440_abnormal_grooming_behavior1.98615317
32MP0002733_abnormal_thermal_nociception1.95996793
33MP0002067_abnormal_sensory_capabilities1.93010252
34MP0005257_abnormal_intraocular_pressure1.90403613
35MP0003300_gastrointestinal_ulcer1.90260124
36MP0005551_abnormal_eye_electrophysiolog1.88143000
37MP0002139_abnormal_hepatobiliary_system1.86169992
38MP0004858_abnormal_nervous_system1.85602261
39MP0008569_lethality_at_weaning1.84607329
40MP0010386_abnormal_urinary_bladder1.84286632
41MP0010352_gastrointestinal_tract_polyps1.82617303
42MP0003879_abnormal_hair_cell1.82426498
43MP0003329_amyloid_beta_deposits1.76242496
44MP0003183_abnormal_peptide_metabolism1.68407944
45MP0002148_abnormal_hypersensitivity_rea1.66138950
46MP0005386_behavior/neurological_phenoty1.61742087
47MP0004924_abnormal_behavior1.61742087
48MP0001984_abnormal_olfaction1.60679842
49MP0005646_abnormal_pituitary_gland1.56683411
50MP0004811_abnormal_neuron_physiology1.55156906
51MP0006054_spinal_hemorrhage1.49683123
52MP0002419_abnormal_innate_immunity1.45807693
53MP0004043_abnormal_pH_regulation1.45474063
54MP0003436_decreased_susceptibility_to1.44355052
55MP0003633_abnormal_nervous_system1.44085830
56MP0001502_abnormal_circadian_rhythm1.43268409
57MP0003724_increased_susceptibility_to1.42168392
58MP0002090_abnormal_vision1.41804459
59MP0002557_abnormal_social/conspecific_i1.41559444
60MP0002184_abnormal_innervation1.40981197
61MP0006276_abnormal_autonomic_nervous1.35976859
62MP0002998_abnormal_bone_remodeling1.34765821
63MP0005464_abnormal_platelet_physiology1.34149862
64MP0004885_abnormal_endolymph1.33290660
65MP0009785_altered_susceptibility_to1.31906669
66MP0003656_abnormal_erythrocyte_physiolo1.31114820
67MP0005165_increased_susceptibility_to1.27499918
68MP0003453_abnormal_keratinocyte_physiol1.26763108
69MP0000751_myopathy1.26255143
70MP0004147_increased_porphyrin_level1.26092520
71MP0002229_neurodegeneration1.24170193
72MP0002066_abnormal_motor_capabilities/c1.23449131
73MP0003172_abnormal_lysosome_physiology1.22953253
74MP0002882_abnormal_neuron_morphology1.21490509
75MP0003448_altered_tumor_morphology1.20019206
76MP0003950_abnormal_plasma_membrane1.18792201
77MP0000371_diluted_coat_color1.18685918
78MP0005645_abnormal_hypothalamus_physiol1.17541848
79MP0000604_amyloidosis1.17481476
80MP0001853_heart_inflammation1.17186113
81MP0008004_abnormal_stomach_pH1.15447000
82MP0003075_altered_response_to1.14667534
83MP0005174_abnormal_tail_pigmentation1.12755818
84MP0002837_dystrophic_cardiac_calcinosis1.11843296
85MP0000013_abnormal_adipose_tissue1.11793480
86MP0004142_abnormal_muscle_tone1.11716651
87MP0003787_abnormal_imprinting1.11413427
88MP0005409_darkened_coat_color1.10698428
89MP0000955_abnormal_spinal_cord1.10396057
90MP0004510_myositis1.10091518
91MP0003091_abnormal_cell_migration1.09889865
92MP0002876_abnormal_thyroid_physiology1.07693099
93MP0005167_abnormal_blood-brain_barrier1.07416782
94MP0003631_nervous_system_phenotype1.06302956
95MP0000569_abnormal_digit_pigmentation1.04053911
96MP0008872_abnormal_physiological_respon1.03652774
97MP0005058_abnormal_lysosome_morphology1.01489201
98MP0004947_skin_inflammation1.00615211
99MP0002638_abnormal_pupillary_reflex0.99427896
100MP0001533_abnormal_skeleton_physiology0.98917303
101MP0000778_abnormal_nervous_system0.98188161
102MP0003566_abnormal_cell_adhesion0.97372519
103MP0003632_abnormal_nervous_system0.96568571
104MP0005535_abnormal_body_temperature0.96521712
105MP0001664_abnormal_digestion0.96482560
106MP0003690_abnormal_glial_cell0.95981680
107MP0004019_abnormal_vitamin_homeostasis0.95959234
108MP0008961_abnormal_basal_metabolism0.95519069
109MP0001905_abnormal_dopamine_level0.95296735
110MP0009764_decreased_sensitivity_to0.94013553
111MP0005365_abnormal_bile_salt0.93719229
112MP0000358_abnormal_cell_content/0.93566105
113MP0000858_altered_metastatic_potential0.92728334
114MP0005408_hypopigmentation0.92318176
115MP0001529_abnormal_vocalization0.90708018
116MP0003195_calcinosis0.90517001
117MP0008874_decreased_physiological_sensi0.89935706
118MP0003122_maternal_imprinting0.89211964
119MP0001765_abnormal_ion_homeostasis0.89121970
120MP0005253_abnormal_eye_physiology0.88999421
121MP0003634_abnormal_glial_cell0.88828194
122MP0001845_abnormal_inflammatory_respons0.88715928
123MP0004484_altered_response_of0.85206620
124MP0010678_abnormal_skin_adnexa0.84567319
125MP0003646_muscle_fatigue0.84012307
126MP0004215_abnormal_myocardial_fiber0.83297090
127MP0006072_abnormal_retinal_apoptosis0.82931864
128MP0002069_abnormal_eating/drinking_beha0.82361031
129MP0010155_abnormal_intestine_physiology0.81779025
130MP0005164_abnormal_response_to0.79310205
131MP0002332_abnormal_exercise_endurance0.78109606
132MP0004036_abnormal_muscle_relaxation0.78090106
133MP0001188_hyperpigmentation0.77404749
134MP0004130_abnormal_muscle_cell0.76657211
135MP0005000_abnormal_immune_tolerance0.76549042
136MP0005310_abnormal_salivary_gland0.74996129
137MP0003221_abnormal_cardiomyocyte_apopto0.74352542
138MP0008469_abnormal_protein_level0.74059522
139MP0004085_abnormal_heartbeat0.74028554
140MP0004742_abnormal_vestibular_system0.72460967
141MP0005166_decreased_susceptibility_to0.72328687
142MP0001177_atelectasis0.72217450
143MP0005025_abnormal_response_to0.71644242
144MP0003186_abnormal_redox_activity0.69965039
145MP0003303_peritoneal_inflammation0.69957166
146MP0003828_pulmonary_edema0.69836503
147MP0000647_abnormal_sebaceous_gland0.69736602
148MP0001963_abnormal_hearing_physiology0.69493684
149MP0003866_abnormal_defecation0.68791158
150MP0000372_irregular_coat_pigmentation0.68194598
151MP0010234_abnormal_vibrissa_follicle0.67758595
152MP0005584_abnormal_enzyme/coenzyme_acti0.67545732
153MP0001986_abnormal_taste_sensitivity0.66852160
154MP0006035_abnormal_mitochondrial_morpho0.66334784
155MP0002152_abnormal_brain_morphology0.64974108
156MP0003283_abnormal_digestive_organ0.64934448
157MP0001756_abnormal_urination0.64677323
158MP0002254_reproductive_system_inflammat0.64573715
159MP0002896_abnormal_bone_mineralization0.63955445
160MP0002452_abnormal_antigen_presenting0.63864730
161MP0004233_abnormal_muscle_weight0.63322574
162MP0000920_abnormal_myelination0.63001015

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.62653932
2Myokymia (HP:0002411)5.55142446
3Vacuolated lymphocytes (HP:0001922)5.28000636
4Visual hallucinations (HP:0002367)4.88799419
5Focal seizures (HP:0007359)4.83113483
6Epileptic encephalopathy (HP:0200134)4.66099713
7Loss of speech (HP:0002371)4.62543156
8Atonic seizures (HP:0010819)4.62077143
9Febrile seizures (HP:0002373)4.52744181
10Absence seizures (HP:0002121)4.18460396
11Dysostosis multiplex (HP:0000943)3.84587146
12Disinhibition (HP:0000734)3.84232010
13Progressive cerebellar ataxia (HP:0002073)3.77506488
14Generalized tonic-clonic seizures (HP:0002069)3.75804975
15Apathy (HP:0000741)3.73501013
16Dialeptic seizures (HP:0011146)3.72260337
17Diminished motivation (HP:0000745)3.67543181
18Supranuclear gaze palsy (HP:0000605)3.52721091
19Abnormality of macrophages (HP:0004311)3.48903793
20Abnormal eating behavior (HP:0100738)3.40968841
21Tetraparesis (HP:0002273)3.38642376
22Action tremor (HP:0002345)3.30977184
23Congenital stationary night blindness (HP:0007642)3.22583626
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.19985551
25Abnormality of polysaccharide metabolism (HP:0011012)3.19985551
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.19985551
27Mucopolysacchariduria (HP:0008155)3.14785840
28Urinary glycosaminoglycan excretion (HP:0003541)3.14785840
29Axonal loss (HP:0003447)3.11479906
30Ankle clonus (HP:0011448)3.08088422
31Upper motor neuron abnormality (HP:0002127)3.06768323
32Pheochromocytoma (HP:0002666)3.05366123
33Depression (HP:0000716)3.00707566
34Central scotoma (HP:0000603)2.99472145
35Truncal ataxia (HP:0002078)2.97251339
36Dysdiadochokinesis (HP:0002075)2.97192068
37Mutism (HP:0002300)2.90655414
38Postural instability (HP:0002172)2.85643579
39Polyphagia (HP:0002591)2.82473471
40Gaze-evoked nystagmus (HP:0000640)2.81652301
41Anxiety (HP:0000739)2.74503594
42Abnormality of binocular vision (HP:0011514)2.72775895
43Diplopia (HP:0000651)2.72775895
44Neuroendocrine neoplasm (HP:0100634)2.68474397
45Dysmetric saccades (HP:0000641)2.66373149
46Agnosia (HP:0010524)2.66244906
47Urinary bladder sphincter dysfunction (HP:0002839)2.63997119
48Broad-based gait (HP:0002136)2.63541294
49Nuclear cataract (HP:0100018)2.63407070
50Myocardial infarction (HP:0001658)2.63075447
51Poor eye contact (HP:0000817)2.60034603
52Hyperventilation (HP:0002883)2.59575436
53Ventricular fibrillation (HP:0001663)2.56603915
54Impaired social interactions (HP:0000735)2.52831422
55Abnormal social behavior (HP:0012433)2.52831422
56Increased cerebral lipofuscin (HP:0011813)2.51615852
57Impaired vibration sensation in the lower limbs (HP:0002166)2.49129677
58Dysmetria (HP:0001310)2.47197623
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45763989
60Progressive inability to walk (HP:0002505)2.43545704
61Progressive neurologic deterioration (HP:0002344)2.43427041
62Abnormality of macular pigmentation (HP:0008002)2.42129372
63Dementia (HP:0000726)2.38742760
64Eczematoid dermatitis (HP:0000976)2.37641238
65Hemiplegia (HP:0002301)2.37468936
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34719622
67Spastic tetraparesis (HP:0001285)2.34419345
68Metabolic alkalosis (HP:0200114)2.33036399
69Bradykinesia (HP:0002067)2.32924854
70Papilledema (HP:0001085)2.31657448
71Hand muscle atrophy (HP:0009130)2.31370604
72Resting tremor (HP:0002322)2.29554198
73Failure to thrive in infancy (HP:0001531)2.29336766
74Metaphyseal irregularity (HP:0003025)2.27065412
75Inappropriate behavior (HP:0000719)2.26913055
76Scanning speech (HP:0002168)2.24861540
77Hypokinesia (HP:0002375)2.23042995
78Recurrent abscess formation (HP:0002722)2.22907611
79Urinary urgency (HP:0000012)2.21157037
80Abnormality of the motor neurons (HP:0002450)2.19869521
81Abnormal neuron morphology (HP:0012757)2.19869521
82Increased circulating renin level (HP:0000848)2.18003674
83Tetraplegia (HP:0002445)2.14977449
84Neuronal loss in central nervous system (HP:0002529)2.14751417
85Genetic anticipation (HP:0003743)2.12820941
86Amblyopia (HP:0000646)2.12309366
87Recurrent bacterial skin infections (HP:0005406)2.11995579
88Personality changes (HP:0000751)2.11604590
89Distal upper limb amyotrophy (HP:0007149)2.11333240
90Upper limb amyotrophy (HP:0009129)2.11333240
91Increased CSF protein (HP:0002922)2.10762338
92Systemic lupus erythematosus (HP:0002725)2.09332685
93Amyotrophic lateral sclerosis (HP:0007354)2.09041453
94Delusions (HP:0000746)2.07776912
95Prolonged neonatal jaundice (HP:0006579)2.06926758
96Impaired smooth pursuit (HP:0007772)2.05646610
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.05164521
98Prolonged QT interval (HP:0001657)2.04663082
99J-shaped sella turcica (HP:0002680)2.03743911
100Vertebral compression fractures (HP:0002953)2.01727177
101Abnormal EKG (HP:0003115)2.01422611
102Torticollis (HP:0000473)1.99437479
103Fetal akinesia sequence (HP:0001989)1.98931283
104Psychosis (HP:0000709)1.98871761
105Abnormality of the periventricular white matter (HP:0002518)1.98632201
106Upper limb muscle weakness (HP:0003484)1.98562379
107Epileptiform EEG discharges (HP:0011182)1.98495435
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.98467045
109Status epilepticus (HP:0002133)1.98064931
110Scotoma (HP:0000575)1.97977713
111Stereotypic behavior (HP:0000733)1.97255374
112Hypercortisolism (HP:0001578)1.97191924
113Hypoventilation (HP:0002791)1.97084011
114Syncope (HP:0001279)1.96726429
115Cardiomegaly (HP:0001640)1.95909203
116Agitation (HP:0000713)1.93985346
117Hepatosplenomegaly (HP:0001433)1.93427483
118Urinary incontinence (HP:0000020)1.90232840
119Retinal atrophy (HP:0001105)1.89512204
120Hemiparesis (HP:0001269)1.89417541
121Hyperactive renin-angiotensin system (HP:0000841)1.89074601
122Inability to walk (HP:0002540)1.89070832
123Intention tremor (HP:0002080)1.88882263
124Neurofibrillary tangles (HP:0002185)1.88812107
125Bone pain (HP:0002653)1.88727322
126EEG with generalized epileptiform discharges (HP:0011198)1.88515662
127Rigidity (HP:0002063)1.86589617
128Abnormality of saccadic eye movements (HP:0000570)1.86405462
129Sensorimotor neuropathy (HP:0007141)1.86200802
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85866693
131Spastic gait (HP:0002064)1.85839342
132Bilateral sensorineural hearing impairment (HP:0008619)1.85339697
133Gait imbalance (HP:0002141)1.84720723
134Malnutrition (HP:0004395)1.84577643
135Akinesia (HP:0002304)1.84251154
136Adrenal overactivity (HP:0002717)1.84065185
137Drooling (HP:0002307)1.83809002
138Excessive salivation (HP:0003781)1.83809002
139Lower limb muscle weakness (HP:0007340)1.83697364
140Abnormality of renin-angiotensin system (HP:0000847)1.83573501
141Oligomenorrhea (HP:0000876)1.83393783
142Interstitial pulmonary disease (HP:0006530)1.83297469
143Ocular albinism (HP:0001107)1.82760958
144Abnormality of the lower motor neuron (HP:0002366)1.82591336
145Tongue fasciculations (HP:0001308)1.82491644
146Decreased circulating renin level (HP:0003351)1.82490836
147Rapidly progressive (HP:0003678)1.81512628
148Focal dystonia (HP:0004373)1.81172234
149Abnormality of ocular smooth pursuit (HP:0000617)1.81062902
150Insidious onset (HP:0003587)1.80730601
151Termporal pattern (HP:0011008)1.80730601
152Spinal canal stenosis (HP:0003416)1.80435744
153Abnormality of proline metabolism (HP:0010907)1.80048648
154Hydroxyprolinuria (HP:0003080)1.80048648
155Neoplasm of the peripheral nervous system (HP:0100007)1.79678110
156Peripheral hypomyelination (HP:0007182)1.79212010
157Amyloidosis (HP:0011034)1.79147778
158Generalized myoclonic seizures (HP:0002123)1.78934410
159Papillary thyroid carcinoma (HP:0002895)1.77780268
160Bundle branch block (HP:0011710)1.76644358
161Global brain atrophy (HP:0002283)1.76567308
162Symptomatic seizures (HP:0011145)1.76516057
163Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76236619
164Cerebral inclusion bodies (HP:0100314)1.73109410
165Postural tremor (HP:0002174)1.72681847
166Cholecystitis (HP:0001082)1.72378684
167Abnormal gallbladder physiology (HP:0012438)1.72378684
168Abnormality of liposaccharide metabolism (HP:0010968)1.71397640
169Abnormality of glycosphingolipid metabolism (HP:0004343)1.71397640
170Abnormality of glycolipid metabolism (HP:0010969)1.71397640
171Cortical dysplasia (HP:0002539)1.70214801
172Pathologic fracture (HP:0002756)1.70133477
173Multiple enchondromatosis (HP:0005701)1.68250262
174Peripheral demyelination (HP:0011096)1.67183955
175Protuberant abdomen (HP:0001538)1.65844923
176Iris hypopigmentation (HP:0007730)1.64471721
177Steatorrhea (HP:0002570)1.64425883
178Horizontal nystagmus (HP:0000666)1.63997684
179Cerebral hemorrhage (HP:0001342)1.63593642
180Hematochezia (HP:0002573)1.63341585
181Abnormality of the costochondral junction (HP:0000919)1.61461314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.84164535
2ACVR1B3.53122805
3MAP3K93.45633297
4IRAK33.42575192
5MAP3K123.04311495
6EPHA42.83556465
7MAP3K42.79033207
8MINK12.58578305
9MAP2K72.54844200
10DAPK22.33089196
11CASK2.30365686
12PBK2.29053054
13KSR22.25805982
14MARK12.18842337
15TESK12.14769221
16RIPK42.08599372
17PAK62.05370299
18CAMKK12.03367326
19LIMK11.96648414
20LATS21.88811007
21PAK41.85508278
22TRIM281.83544410
23MAP2K41.82180254
24ARAF1.75070891
25NTRK11.72030578
26LMTK21.69312522
27CAMKK21.66188426
28MAP3K141.64461925
29PRPF4B1.64107079
30NTRK21.61975192
31MAP3K31.59084891
32FGR1.56443114
33ERBB41.55165683
34DAPK11.53973359
35MAP3K21.48641369
36MAP3K131.42387806
37STK381.41494110
38GRK51.41023640
39PLK21.39548664
40MATK1.39482769
41CDK51.37812219
42ABL21.36514653
43BCR1.29787601
44CDK191.24981863
45OXSR11.24783295
46SGK2231.24254983
47SGK4941.24254983
48FES1.24031510
49PRKD31.23442075
50YES11.22870125
51CSNK1G21.17699588
52EIF2AK31.16729514
53MST41.16709337
54ERBB31.15479281
55PHKG11.14998088
56PHKG21.14998088
57MST1R1.13778282
58SGK21.12846162
59TAOK21.11874176
60KSR11.10082839
61MAP3K51.08106309
62SGK31.05835263
63NEK11.04067989
64EPHA21.03002829
65NEK61.02609973
66PINK11.01570618
67PRKCH1.01244331
68PRKCG1.01212673
69TBK10.95625664
70TAOK10.95477286
71TSSK60.93910902
72NME20.93482862
73SIK20.92176876
74MOS0.91689472
75DDR20.90580572
76EIF2AK10.90549952
77AKT30.90175027
78MAP3K10.89751068
79RIPK10.88743384
80TYK20.87754664
81TNK20.87746337
82CAMK2A0.87230881
83CSNK1G30.86711882
84EPHB10.85941261
85RET0.85335937
86PIM20.80975473
87PAK30.80094816
88SCYL20.73517763
89CAMK10.71746572
90PDK10.70372922
91SIK30.70035265
92IRAK20.68967192
93PDPK10.68917874
94TGFBR20.68867493
95PRKCE0.68734184
96MYLK0.68535229
97CSNK1A1L0.68406751
98MAPK130.67937987
99FER0.67563902
100SGK10.67008470
101CDK180.66462666
102WNK30.66271038
103STK110.65813153
104PDGFRA0.64663424
105ALK0.64341122
106WNK10.64268838
107WNK40.64017264
108MAP2K10.63405920
109BMPR20.63341387
110ROCK20.62639574
111CDK150.62464529
112CDK140.61900127
113CAMK2D0.61253621
114CDK60.60405100
115RAF10.59142634
116NME10.58962225
117PTK20.58390703
118UHMK10.57845945
119GRK70.57645473
120PDK20.56462575
121CAMK2B0.56230563
122MAP3K110.53639333
123TNIK0.53037413
124FYN0.52256689
125RPS6KA20.52219281
126PTK2B0.51094366
127CDK11A0.50150192
128CDC42BPA0.48496888
129DAPK30.48398506
130FRK0.47712562
131CAMK2G0.47407739
132EGFR0.46642846
133PDK40.46205616
134PDK30.46205616
135ZAP700.45716769
136BRAF0.43325821
137PRKCZ0.42901511
138CSNK1G10.41432666
139RPS6KA30.41256212
140MAP3K70.39969884
141ADRBK10.38753088
142JAK10.38487179
143PRKG20.36861326
144CSK0.36670011
145JAK20.36655529
146TESK20.36113838
147CCNB10.34660572
148DYRK1A0.34371962
149MAPK120.34121780
150PRKCA0.33735004

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.74564599
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.53647975
3Other glycan degradation_Homo sapiens_hsa005113.11322344
4Nicotine addiction_Homo sapiens_hsa050333.09289639
5Collecting duct acid secretion_Homo sapiens_hsa049662.54771534
6GABAergic synapse_Homo sapiens_hsa047272.53399912
7Olfactory transduction_Homo sapiens_hsa047402.47519552
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.42383596
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33970306
10Morphine addiction_Homo sapiens_hsa050322.28004311
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23459899
12Circadian entrainment_Homo sapiens_hsa047132.20803742
13Long-term potentiation_Homo sapiens_hsa047201.93698010
14Glutamatergic synapse_Homo sapiens_hsa047241.93456688
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88268765
16Salivary secretion_Homo sapiens_hsa049701.87528160
17Sulfur metabolism_Homo sapiens_hsa009201.85999657
18Phototransduction_Homo sapiens_hsa047441.79892408
19Insulin secretion_Homo sapiens_hsa049111.79890136
20Gastric acid secretion_Homo sapiens_hsa049711.77517935
21Dopaminergic synapse_Homo sapiens_hsa047281.74918897
22Amphetamine addiction_Homo sapiens_hsa050311.74238319
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69958288
24Legionellosis_Homo sapiens_hsa051341.64588154
25Cholinergic synapse_Homo sapiens_hsa047251.61880021
26Vibrio cholerae infection_Homo sapiens_hsa051101.58007683
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57543223
28Renin secretion_Homo sapiens_hsa049241.56901843
29Taste transduction_Homo sapiens_hsa047421.53271729
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48985559
31Sphingolipid metabolism_Homo sapiens_hsa006001.45105555
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41922663
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39803048
34Serotonergic synapse_Homo sapiens_hsa047261.39368967
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36822200
36Shigellosis_Homo sapiens_hsa051311.35815354
37Oxytocin signaling pathway_Homo sapiens_hsa049211.34476539
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33955488
39Long-term depression_Homo sapiens_hsa047301.28444483
40Steroid biosynthesis_Homo sapiens_hsa001001.27337366
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26667993
42Cocaine addiction_Homo sapiens_hsa050301.25636652
43Galactose metabolism_Homo sapiens_hsa000521.23304494
44Calcium signaling pathway_Homo sapiens_hsa040201.22600095
45Osteoclast differentiation_Homo sapiens_hsa043801.22043382
46Fatty acid elongation_Homo sapiens_hsa000621.19167528
47GnRH signaling pathway_Homo sapiens_hsa049121.15093666
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13316615
49Type II diabetes mellitus_Homo sapiens_hsa049301.13112131
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12876386
51Vitamin B6 metabolism_Homo sapiens_hsa007501.11113087
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08705947
53Pertussis_Homo sapiens_hsa051331.07053996
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04485941
55Gap junction_Homo sapiens_hsa045401.01493465
56cAMP signaling pathway_Homo sapiens_hsa040241.01130275
57Rheumatoid arthritis_Homo sapiens_hsa053230.99429359
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98181603
59Type I diabetes mellitus_Homo sapiens_hsa049400.95449972
60Pentose phosphate pathway_Homo sapiens_hsa000300.94808023
61Cardiac muscle contraction_Homo sapiens_hsa042600.93301529
62Folate biosynthesis_Homo sapiens_hsa007900.92724593
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92514571
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88026144
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86359684
66Mineral absorption_Homo sapiens_hsa049780.86089384
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85156852
68Estrogen signaling pathway_Homo sapiens_hsa049150.83103751
69Dilated cardiomyopathy_Homo sapiens_hsa054140.80051392
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79482412
71Glioma_Homo sapiens_hsa052140.78190583
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.78140216
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77794344
74Lysosome_Homo sapiens_hsa041420.76100165
75Phagosome_Homo sapiens_hsa041450.75897975
76Pancreatic secretion_Homo sapiens_hsa049720.75297695
77TNF signaling pathway_Homo sapiens_hsa046680.74267549
78ErbB signaling pathway_Homo sapiens_hsa040120.71046891
79Thyroid hormone synthesis_Homo sapiens_hsa049180.69540850
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68171351
81Leishmaniasis_Homo sapiens_hsa051400.67137303
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66673143
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65817960
84Regulation of autophagy_Homo sapiens_hsa041400.62342594
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.62091748
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62027241
87Inositol phosphate metabolism_Homo sapiens_hsa005620.61136935
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60150336
89HIF-1 signaling pathway_Homo sapiens_hsa040660.59869097
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59494870
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.59055829
92Chemokine signaling pathway_Homo sapiens_hsa040620.57998017
93Endocytosis_Homo sapiens_hsa041440.57910183
94MAPK signaling pathway_Homo sapiens_hsa040100.56954845
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55499472
96Bladder cancer_Homo sapiens_hsa052190.55014193
97Bile secretion_Homo sapiens_hsa049760.54346850
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54041437
99N-Glycan biosynthesis_Homo sapiens_hsa005100.54004874
100Toxoplasmosis_Homo sapiens_hsa051450.53607089
101Circadian rhythm_Homo sapiens_hsa047100.53096071
102Dorso-ventral axis formation_Homo sapiens_hsa043200.51155631
103Salmonella infection_Homo sapiens_hsa051320.50916403
104Tuberculosis_Homo sapiens_hsa051520.50435063
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50394232
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.49231065
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48969463
108Melanogenesis_Homo sapiens_hsa049160.48649541
109Hepatitis C_Homo sapiens_hsa051600.48274298
110Axon guidance_Homo sapiens_hsa043600.48028168
111Choline metabolism in cancer_Homo sapiens_hsa052310.47628068
112Amoebiasis_Homo sapiens_hsa051460.47420152
113Renal cell carcinoma_Homo sapiens_hsa052110.46317381
114Glutathione metabolism_Homo sapiens_hsa004800.43725505
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43720677
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43403584
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43186383
118VEGF signaling pathway_Homo sapiens_hsa043700.43031908
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.42327962
120Carbon metabolism_Homo sapiens_hsa012000.39384667
121Ras signaling pathway_Homo sapiens_hsa040140.39088761
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39030066
123Oxidative phosphorylation_Homo sapiens_hsa001900.38387437
124PPAR signaling pathway_Homo sapiens_hsa033200.38230662
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.38090018
126Apoptosis_Homo sapiens_hsa042100.37448890
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37352015
128mTOR signaling pathway_Homo sapiens_hsa041500.36417187
129Staphylococcus aureus infection_Homo sapiens_hsa051500.36384983
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36331189
131Rap1 signaling pathway_Homo sapiens_hsa040150.36286790
132Fructose and mannose metabolism_Homo sapiens_hsa000510.35649420
133Alzheimers disease_Homo sapiens_hsa050100.35414826
134Influenza A_Homo sapiens_hsa051640.35324545
135Glucagon signaling pathway_Homo sapiens_hsa049220.34502868
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34450956
137Endometrial cancer_Homo sapiens_hsa052130.34413608
138Insulin signaling pathway_Homo sapiens_hsa049100.33574465
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32109624
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31071054
141Fatty acid biosynthesis_Homo sapiens_hsa000610.30351560
142Fatty acid metabolism_Homo sapiens_hsa012120.30335816
143Protein export_Homo sapiens_hsa030600.29877037
144Prion diseases_Homo sapiens_hsa050200.29797802
145Prolactin signaling pathway_Homo sapiens_hsa049170.29150987
146Renin-angiotensin system_Homo sapiens_hsa046140.29004362
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28095452
148Oocyte meiosis_Homo sapiens_hsa041140.27250163
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25424965
150Hepatitis B_Homo sapiens_hsa051610.23590398

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