PLEKHA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.46667717
2paraxial mesoderm development (GO:0048339)4.44868666
3nuclear pore complex assembly (GO:0051292)4.28193569
4monoubiquitinated protein deubiquitination (GO:0035520)4.12930422
5synaptonemal complex assembly (GO:0007130)4.04193366
6regulation of meiosis I (GO:0060631)4.03911270
7nuclear pore organization (GO:0006999)3.93313755
8male meiosis (GO:0007140)3.89939882
9DNA unwinding involved in DNA replication (GO:0006268)3.78504925
10heterochromatin organization (GO:0070828)3.78396418
11DNA methylation involved in gamete generation (GO:0043046)3.70701534
12synaptonemal complex organization (GO:0070193)3.70298171
13establishment of integrated proviral latency (GO:0075713)3.70154565
14pre-miRNA processing (GO:0031054)3.64588843
15mitotic metaphase plate congression (GO:0007080)3.55550675
16mitotic sister chromatid cohesion (GO:0007064)3.54085355
17histone H2A monoubiquitination (GO:0035518)3.50685538
18mitotic chromosome condensation (GO:0007076)3.41561211
19regulation of sister chromatid cohesion (GO:0007063)3.41184631
20DNA topological change (GO:0006265)3.37636589
21metaphase plate congression (GO:0051310)3.28594943
22DNA replication-dependent nucleosome assembly (GO:0006335)3.27045253
23DNA replication-dependent nucleosome organization (GO:0034723)3.27045253
24serine family amino acid catabolic process (GO:0009071)3.24311203
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.23742644
26L-phenylalanine catabolic process (GO:0006559)3.23742644
27meiotic chromosome segregation (GO:0045132)3.17441831
28urea metabolic process (GO:0019627)3.16508487
29urea cycle (GO:0000050)3.16508487
30sister chromatid cohesion (GO:0007062)3.13975764
31gene silencing by RNA (GO:0031047)3.10218038
32L-phenylalanine metabolic process (GO:0006558)3.09737141
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09737141
34regulation of hippo signaling (GO:0035330)3.09706664
35male meiosis I (GO:0007141)3.05184820
36nucleosome disassembly (GO:0006337)3.04843550
37protein-DNA complex disassembly (GO:0032986)3.04843550
38regulation of RNA export from nucleus (GO:0046831)3.03570902
39double-strand break repair via nonhomologous end joining (GO:0006303)3.03274386
40non-recombinational repair (GO:0000726)3.03274386
41convergent extension (GO:0060026)3.01747807
42kinetochore organization (GO:0051383)2.98129082
43glyoxylate metabolic process (GO:0046487)2.97256811
44ATP-dependent chromatin remodeling (GO:0043044)2.97020544
45NLS-bearing protein import into nucleus (GO:0006607)2.96601213
46dorsal/ventral axis specification (GO:0009950)2.96450462
47drug catabolic process (GO:0042737)2.94722278
48male genitalia development (GO:0030539)2.92929854
49negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92597943
50DNA damage induced protein phosphorylation (GO:0006975)2.92364959
51planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91414231
52kinetochore assembly (GO:0051382)2.91128771
53resolution of meiotic recombination intermediates (GO:0000712)2.89080185
54meiotic nuclear division (GO:0007126)2.86977163
55chromosome organization involved in meiosis (GO:0070192)2.85388595
56gastrulation with mouth forming second (GO:0001702)2.85238366
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85236188
58notochord development (GO:0030903)2.84478567
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.83478823
60nitrogen cycle metabolic process (GO:0071941)2.82107422
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81652942
62homocysteine metabolic process (GO:0050667)2.81526760
63regulation of centriole replication (GO:0046599)2.80721857
64negative regulation of histone methylation (GO:0031061)2.80394314
65pore complex assembly (GO:0046931)2.80170663
66tyrosine metabolic process (GO:0006570)2.79948390
67presynaptic membrane assembly (GO:0097105)2.78842149
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78774144
69negative regulation of translation, ncRNA-mediated (GO:0040033)2.78774144
70regulation of translation, ncRNA-mediated (GO:0045974)2.78774144
71attachment of spindle microtubules to kinetochore (GO:0008608)2.78400555
72aromatic amino acid family catabolic process (GO:0009074)2.76516028
73negative regulation of fatty acid biosynthetic process (GO:0045717)2.74966938
74mitotic nuclear envelope disassembly (GO:0007077)2.74579209
75histone exchange (GO:0043486)2.73998376
76protein K6-linked ubiquitination (GO:0085020)2.72866894
77regulation of nucleobase-containing compound transport (GO:0032239)2.71487983
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.70682326
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.70682326
80positive regulation of mitotic sister chromatid separation (GO:1901970)2.70682326
81DNA duplex unwinding (GO:0032508)2.70351426
82glycine metabolic process (GO:0006544)2.69407502
83cysteine metabolic process (GO:0006534)2.69239572
84positive regulation of chromosome segregation (GO:0051984)2.69131078
85protein complex localization (GO:0031503)2.68222151
86regulation of growth hormone secretion (GO:0060123)2.67604348
87meiosis I (GO:0007127)2.66960959
88mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66732926
89negative regulation of DNA repair (GO:0045738)2.66521964
90regulation of gene silencing by RNA (GO:0060966)2.66507547
91regulation of posttranscriptional gene silencing (GO:0060147)2.66507547
92regulation of gene silencing by miRNA (GO:0060964)2.66507547
93regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.65718334
94DNA methylation (GO:0006306)2.63642308
95DNA alkylation (GO:0006305)2.63642308
96regulation of NFAT protein import into nucleus (GO:0051532)2.63599505
97cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63549521
98meiotic cell cycle (GO:0051321)2.63465129
99CENP-A containing nucleosome assembly (GO:0034080)2.63239853
100embryonic foregut morphogenesis (GO:0048617)2.62461687
101DNA geometric change (GO:0032392)2.62431223
102establishment of chromosome localization (GO:0051303)2.62422000
103meiotic cell cycle process (GO:1903046)2.61477541
104intestinal absorption (GO:0050892)2.61103217
105establishment of viral latency (GO:0019043)2.60654515
106histone lysine demethylation (GO:0070076)2.60614558
107microtubule depolymerization (GO:0007019)2.60511839
108histone H3-K9 demethylation (GO:0033169)2.59742754
109nuclear envelope disassembly (GO:0051081)2.58864560
110membrane disassembly (GO:0030397)2.58864560
111cytoplasmic mRNA processing body assembly (GO:0033962)2.58055451
112inner cell mass cell proliferation (GO:0001833)2.57984714
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.57548592
114regulation of centrosome cycle (GO:0046605)2.57371351
115DNA ligation (GO:0006266)2.57301835
116interkinetic nuclear migration (GO:0022027)2.57252646
117hippo signaling (GO:0035329)2.56884022
118protein localization to chromosome, centromeric region (GO:0071459)2.56637075
119axon extension involved in axon guidance (GO:0048846)2.56464723
120neuron projection extension involved in neuron projection guidance (GO:1902284)2.56464723
121sister chromatid segregation (GO:0000819)2.56320946
122chromosome segregation (GO:0007059)2.55927005
123regulation of histone H3-K9 methylation (GO:0051570)2.54843151
124histone demethylation (GO:0016577)2.54477645
125chromatin assembly (GO:0031497)2.52220893
126establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.51826369
127serine family amino acid metabolic process (GO:0009069)2.51397504
128imidazole-containing compound metabolic process (GO:0052803)2.51348436
129urate metabolic process (GO:0046415)2.51005292
130regulation of protein polyubiquitination (GO:1902914)2.50858886
131presynaptic membrane organization (GO:0097090)2.50561703
132mitotic sister chromatid segregation (GO:0000070)2.50016192
133chromatin remodeling at centromere (GO:0031055)2.48960542
134positive regulation of catenin import into nucleus (GO:0035413)2.48770349
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48378205
136ectodermal placode formation (GO:0060788)2.48145324
137protein localization to kinetochore (GO:0034501)2.47622051
138DNA replication-independent nucleosome organization (GO:0034724)2.47303851
139DNA replication-independent nucleosome assembly (GO:0006336)2.47303851
140regulation of chromosome segregation (GO:0051983)2.46081861
141regulation of bile acid biosynthetic process (GO:0070857)2.45747727
142one-carbon metabolic process (GO:0006730)2.45324690
143generation of neurons (GO:0048699)2.44876923
144protein localization to chromosome (GO:0034502)2.44813223
145oocyte maturation (GO:0001556)2.43829524
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.43520644
147RNA stabilization (GO:0043489)2.42579215
148mRNA stabilization (GO:0048255)2.42579215
149cellular protein complex localization (GO:0034629)2.42496538
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42119785
151L-serine metabolic process (GO:0006563)2.41149967
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40631845
153lung-associated mesenchyme development (GO:0060484)2.39538302
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.37887999
155regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37887999
156regulation of stem cell maintenance (GO:2000036)2.37691452
157DNA strand elongation involved in DNA replication (GO:0006271)2.37219656
158morphogenesis of an epithelial sheet (GO:0002011)2.37009678
159apical protein localization (GO:0045176)2.36892574
160regulation of centrosome duplication (GO:0010824)2.36869446
161regulation of translational fidelity (GO:0006450)2.35701298
162spindle checkpoint (GO:0031577)2.35289612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87757844
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.63782176
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.86268226
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.82630554
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25715133
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13675439
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00290033
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84858583
9AR_21909140_ChIP-Seq_LNCAP_Human2.83410516
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.66249772
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65152377
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.60421882
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.57610869
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46965655
15* WT1_19549856_ChIP-ChIP_CCG9911_Human2.34790089
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.20858253
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.12659489
18* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08535796
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94502715
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91828738
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89424211
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89221554
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.88508559
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.72087066
25* SOX2_16153702_ChIP-ChIP_HESCs_Human1.64525798
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63013597
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62484369
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61855167
29SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.58111795
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57908867
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55901645
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55901645
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55901645
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.52763133
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49409022
36* NANOG_16153702_ChIP-ChIP_HESCs_Human1.49302302
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46229668
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44859882
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44043005
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.43197513
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42900744
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41447531
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.40068495
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39255548
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37830239
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35556884
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33667846
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31730743
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28086765
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27226844
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26303220
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23679928
53* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23175594
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22539460
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20926204
56EWS_26573619_Chip-Seq_HEK293_Human1.20448651
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.20390667
58SOX9_26525672_Chip-Seq_HEART_Mouse1.20190858
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18926797
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18502872
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17686028
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16133306
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16058263
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15992205
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15068365
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13946639
67KDM5A_27292631_Chip-Seq_BREAST_Human1.13411548
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13389643
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13117054
70RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09980743
71CLOCK_20551151_ChIP-Seq_293T_Human1.09554011
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09209083
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08951529
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.08095086
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07518144
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05330096
77TAF15_26573619_Chip-Seq_HEK293_Human1.05255959
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05167762
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04147489
80FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04035646
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03165138
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.02838087
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02663143
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02407454
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02349541
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.01823153
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01174495
88NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00668869
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99862491
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99484165
91TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99343086
92ELK1_19687146_ChIP-ChIP_HELA_Human0.97685913
93MYC_18555785_ChIP-Seq_MESCs_Mouse0.97039100
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96713323
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96654227
96RNF2_27304074_Chip-Seq_NSC_Mouse0.96439845
97IGF1R_20145208_ChIP-Seq_DFB_Human0.95292415
98CDX2_22108803_ChIP-Seq_LS180_Human0.93922709
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93225019
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92746425
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92542007
102MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92499553
103FUS_26573619_Chip-Seq_HEK293_Human0.92351217
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91585849
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91558900
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90483533
107* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89946735
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89778610
109KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89463246
110SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89162814
111NANOG_16518401_ChIP-PET_MESCs_Mouse0.87901889
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87288343
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86603513
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86430334
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85843302
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.85759868
117P300_19829295_ChIP-Seq_ESCs_Human0.85700123
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85604167
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85391809
120CHD1_26751641_Chip-Seq_LNCaP_Human0.85190040
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85068037
122* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84978226
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84429477
124GATA6_25053715_ChIP-Seq_YYC3_Human0.84317325
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84316824
126* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84039054
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83649993
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83435246
129XRN2_22483619_ChIP-Seq_HELA_Human0.83390944
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83192821
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83192821
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83089823
133NANOG_18692474_ChIP-Seq_MESCs_Mouse0.82301789
134STAT1_17558387_ChIP-Seq_HELA_Human0.81003499
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80860483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.00125635
2MP0005360_urolithiasis3.63136473
3MP0008877_abnormal_DNA_methylation2.93523924
4MP0005365_abnormal_bile_salt2.85671654
5MP0005085_abnormal_gallbladder_physiolo2.82616702
6MP0009053_abnormal_anal_canal2.53816600
7MP0003890_abnormal_embryonic-extraembry2.50441007
8MP0003123_paternal_imprinting2.40247431
9MP0003941_abnormal_skin_development2.39673203
10MP0008057_abnormal_DNA_replication2.28760537
11MP0003693_abnormal_embryo_hatching2.22012955
12MP0003252_abnormal_bile_duct2.09244717
13MP0003806_abnormal_nucleotide_metabolis2.04330642
14MP0010094_abnormal_chromosome_stability2.03687748
15MP0008875_abnormal_xenobiotic_pharmacok2.00423519
16MP0004264_abnormal_extraembryonic_tissu1.96531738
17MP0003121_genomic_imprinting1.95403649
18MP0005408_hypopigmentation1.94243808
19MP0003111_abnormal_nucleus_morphology1.91665686
20MP0003122_maternal_imprinting1.87821138
21MP0004957_abnormal_blastocyst_morpholog1.85825180
22MP0000537_abnormal_urethra_morphology1.83942455
23MP0003077_abnormal_cell_cycle1.83106299
24MP0003937_abnormal_limbs/digits/tail_de1.82102096
25MP0000778_abnormal_nervous_system1.79096894
26MP0000566_synostosis1.73517355
27MP0004272_abnormal_basement_membrane1.71731274
28MP0003705_abnormal_hypodermis_morpholog1.69446493
29MP0002653_abnormal_ependyma_morphology1.69256326
30MP0001730_embryonic_growth_arrest1.69250964
31MP0003119_abnormal_digestive_system1.69213475
32MP0001299_abnormal_eye_distance/1.67562962
33MP0003718_maternal_effect1.67195926
34MP0002210_abnormal_sex_determination1.62206391
35MP0003787_abnormal_imprinting1.61315459
36MP0005187_abnormal_penis_morphology1.60585574
37MP0005451_abnormal_body_composition1.60082062
38MP0003315_abnormal_perineum_morphology1.57812010
39MP0010234_abnormal_vibrissa_follicle1.52398364
40MP0001929_abnormal_gametogenesis1.51694224
41MP0002084_abnormal_developmental_patter1.50881189
42MP0005380_embryogenesis_phenotype1.48134571
43MP0001672_abnormal_embryogenesis/_devel1.48134571
44MP0010352_gastrointestinal_tract_polyps1.45484483
45MP0008007_abnormal_cellular_replicative1.41021655
46MP0002085_abnormal_embryonic_tissue1.40201320
47MP0002102_abnormal_ear_morphology1.38688764
48MP0000579_abnormal_nail_morphology1.37057188
49MP0003385_abnormal_body_wall1.36313842
50MP0001145_abnormal_male_reproductive1.35087108
51MP0000653_abnormal_sex_gland1.34794946
52MP0002111_abnormal_tail_morphology1.34163873
53MP0001697_abnormal_embryo_size1.32132661
54MP0001666_abnormal_nutrient_absorption1.31407020
55MP0003984_embryonic_growth_retardation1.30249808
56MP0008058_abnormal_DNA_repair1.29916433
57MP0002088_abnormal_embryonic_growth/wei1.28266155
58MP0000350_abnormal_cell_proliferation1.26001894
59MP0000534_abnormal_ureter_morphology1.25684861
60MP0000049_abnormal_middle_ear1.25035197
61MP0005248_abnormal_Harderian_gland1.23653387
62MP0008932_abnormal_embryonic_tissue1.22204988
63MP0009697_abnormal_copulation1.20849119
64MP0005499_abnormal_olfactory_system1.20069725
65MP0005394_taste/olfaction_phenotype1.20069725
66MP0005257_abnormal_intraocular_pressure1.19754202
67MP0003868_abnormal_feces_composition1.18215016
68MP0001293_anophthalmia1.18193736
69MP0010030_abnormal_orbit_morphology1.17907620
70MP0001849_ear_inflammation1.14396867
71MP0010307_abnormal_tumor_latency1.13675727
72MP0003698_abnormal_male_reproductive1.13468818
73MP0002086_abnormal_extraembryonic_tissu1.13439889
74MP0003115_abnormal_respiratory_system1.09436890
75MP0001119_abnormal_female_reproductive1.09148532
76MP0006292_abnormal_olfactory_placode1.08453129
77MP0010329_abnormal_lipoprotein_level1.06782350
78MP0003567_abnormal_fetal_cardiomyocyte1.06643501
79MP0009672_abnormal_birth_weight1.06429609
80MP0004197_abnormal_fetal_growth/weight/1.05205913
81MP0004233_abnormal_muscle_weight1.04931388
82MP0002081_perinatal_lethality1.03983964
83MP0001346_abnormal_lacrimal_gland1.00397568
84MP0002116_abnormal_craniofacial_bone0.98751649
85MP0003755_abnormal_palate_morphology0.98714456
86MP0002009_preneoplasia0.98359082
87MP0009703_decreased_birth_body0.97416980
88MP0002234_abnormal_pharynx_morphology0.96932105
89MP0003136_yellow_coat_color0.96145061
90MP0002751_abnormal_autonomic_nervous0.95318678
91MP0003699_abnormal_female_reproductive0.94896009
92MP0003938_abnormal_ear_development0.94201298
93MP0000462_abnormal_digestive_system0.94088854
94MP0003935_abnormal_craniofacial_develop0.93236233
95MP0002249_abnormal_larynx_morphology0.92628784
96MP0002152_abnormal_brain_morphology0.92246830
97MP0005409_darkened_coat_color0.91980920
98MP0001324_abnormal_eye_pigmentation0.91929308
99MP0005391_vision/eye_phenotype0.91030932
100MP0001529_abnormal_vocalization0.90724464
101MP0000569_abnormal_digit_pigmentation0.90529350
102MP0002161_abnormal_fertility/fecundity0.90490935
103MP0003942_abnormal_urinary_system0.89747871
104MP0000955_abnormal_spinal_cord0.89544003
105MP0002184_abnormal_innervation0.89468887
106MP0000432_abnormal_head_morphology0.89268556
107MP0002092_abnormal_eye_morphology0.88614557
108MP0002233_abnormal_nose_morphology0.88567845
109MP0001177_atelectasis0.88384546
110MP0002697_abnormal_eye_size0.88177238
111MP0000647_abnormal_sebaceous_gland0.86093306
112MP0000762_abnormal_tongue_morphology0.86077030
113MP0002089_abnormal_postnatal_growth/wei0.85740390
114MP0002080_prenatal_lethality0.84936607
115MP0005076_abnormal_cell_differentiation0.84914240
116MP0005647_abnormal_sex_gland0.84716052
117MP0000427_abnormal_hair_cycle0.84451067
118MP0005395_other_phenotype0.84226409
119MP0003221_abnormal_cardiomyocyte_apopto0.83899222
120MP0008789_abnormal_olfactory_epithelium0.83795202
121MP0000428_abnormal_craniofacial_morphol0.83299959
122MP0002282_abnormal_trachea_morphology0.83179738
123MP0001286_abnormal_eye_development0.82745911
124MP0001340_abnormal_eyelid_morphology0.81808393
125MP0005623_abnormal_meninges_morphology0.81722502
126MP0004019_abnormal_vitamin_homeostasis0.81146827
127MP0002938_white_spotting0.81097719
128MP0003566_abnormal_cell_adhesion0.79854236
129MP0002877_abnormal_melanocyte_morpholog0.79189604
130MP0005410_abnormal_fertilization0.78988025
131MP0003011_delayed_dark_adaptation0.78977696
132MP0005332_abnormal_amino_acid0.78630268
133MP0009250_abnormal_appendicular_skeleto0.77732136
134MP0003861_abnormal_nervous_system0.77526047
135MP0001915_intracranial_hemorrhage0.76943352
136MP0002114_abnormal_axial_skeleton0.76926635
137MP0002160_abnormal_reproductive_system0.72414575
138MP0001764_abnormal_homeostasis0.72370491

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.46166952
2Cortical dysplasia (HP:0002539)3.54856445
3Shawl scrotum (HP:0000049)3.41504333
4Hypobetalipoproteinemia (HP:0003563)3.39370950
5Intrahepatic cholestasis (HP:0001406)3.37585212
6Abnormality of monocarboxylic acid metabolism (HP:0010996)2.90117110
7Deep venous thrombosis (HP:0002625)2.86386954
8Chromsome breakage (HP:0040012)2.83915743
9Increased nuchal translucency (HP:0010880)2.77771393
10Abnormality of the lower motor neuron (HP:0002366)2.76760796
11Facial hemangioma (HP:0000329)2.74087410
12Chorioretinal atrophy (HP:0000533)2.70586792
13Thyroid carcinoma (HP:0002890)2.61849199
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61035023
15Abnormality of the labia minora (HP:0012880)2.55732816
16Rhabdomyosarcoma (HP:0002859)2.49346832
17Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49186485
18Abnormal lung lobation (HP:0002101)2.48521193
19Hypochromic microcytic anemia (HP:0004840)2.47809190
20Male infertility (HP:0003251)2.42948702
21Impulsivity (HP:0100710)2.41145468
22Vitreoretinal degeneration (HP:0000655)2.38064508
23Abnormality of sulfur amino acid metabolism (HP:0004339)2.37236105
24Spontaneous abortion (HP:0005268)2.35442492
25Hypolipoproteinemia (HP:0010981)2.30704815
26Cutaneous finger syndactyly (HP:0010554)2.29034050
27Epidermoid cyst (HP:0200040)2.28244125
28Pigmentary retinal degeneration (HP:0001146)2.28047938
29Neoplasm of the oral cavity (HP:0100649)2.27751576
30Ectopic kidney (HP:0000086)2.26413960
31Cutaneous syndactyly (HP:0012725)2.24808137
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18662375
33Abnormality of the phalanges of the hallux (HP:0010057)2.17991146
34Hepatoblastoma (HP:0002884)2.17572519
35Myelomeningocele (HP:0002475)2.17373548
36Dyschromatopsia (HP:0007641)2.16578629
37Birth length less than 3rd percentile (HP:0003561)2.15225505
38Patellar aplasia (HP:0006443)2.14891033
39Asymmetry of the thorax (HP:0001555)2.12640760
40Absent eyebrow (HP:0002223)2.11678798
41Azoospermia (HP:0000027)2.10805669
42Proximal tubulopathy (HP:0000114)2.08475408
43Hyperglycinemia (HP:0002154)2.07778294
44Colon cancer (HP:0003003)2.07544397
45Skull defect (HP:0001362)2.06761803
46Gastrointestinal carcinoma (HP:0002672)2.06166646
47Malignant gastrointestinal tract tumors (HP:0006749)2.06166646
48Omphalocele (HP:0001539)2.06051042
49Missing ribs (HP:0000921)2.05850111
50Xanthomatosis (HP:0000991)2.04942084
51Capillary hemangiomas (HP:0005306)2.04756312
52Insidious onset (HP:0003587)2.02144718
53Termporal pattern (HP:0011008)2.02144718
54Medulloblastoma (HP:0002885)2.01934970
55Trigonocephaly (HP:0000243)2.01902499
56Hepatocellular carcinoma (HP:0001402)2.01774824
57Breast hypoplasia (HP:0003187)2.00524488
58Overriding aorta (HP:0002623)1.99968863
59Partial agenesis of the corpus callosum (HP:0001338)1.98893782
60Nephroblastoma (Wilms tumor) (HP:0002667)1.98440640
61Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97595130
62Aplasia/Hypoplasia of the patella (HP:0006498)1.96343960
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95948472
64Short 4th metacarpal (HP:0010044)1.95948472
65Leiomyosarcoma (HP:0100243)1.95852653
66Uterine leiomyosarcoma (HP:0002891)1.95852653
67Obsessive-compulsive behavior (HP:0000722)1.95085766
68Broad thumb (HP:0011304)1.95054059
69Abnormality of chromosome stability (HP:0003220)1.94260207
70Bilateral microphthalmos (HP:0007633)1.92539752
71Gonadotropin excess (HP:0000837)1.91689943
72Volvulus (HP:0002580)1.91675533
73Transitional cell carcinoma of the bladder (HP:0006740)1.91274345
74Abnormal spermatogenesis (HP:0008669)1.90624545
75Bifid tongue (HP:0010297)1.90553528
76Renal duplication (HP:0000075)1.89934080
77Abnormality of pyrimidine metabolism (HP:0004353)1.89503616
78Abnormality of the 4th metacarpal (HP:0010012)1.89370872
79Adrenal hypoplasia (HP:0000835)1.89181502
80Ependymoma (HP:0002888)1.89156272
81Hypoplastic labia majora (HP:0000059)1.89008252
82Abnormality of methionine metabolism (HP:0010901)1.88550000
83Microglossia (HP:0000171)1.87814975
84Hyperglycinuria (HP:0003108)1.87628005
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.87582353
86Embryonal renal neoplasm (HP:0011794)1.86963129
87Neoplasm of striated muscle (HP:0009728)1.86553995
88Sandal gap (HP:0001852)1.86238500
89Abnormality of the antihelix (HP:0009738)1.85335035
90Abnormality of the astrocytes (HP:0100707)1.85089974
91Astrocytoma (HP:0009592)1.85089974
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84558671
93Renal hypoplasia (HP:0000089)1.84506678
94Deviation of the thumb (HP:0009603)1.83960749
95Intestinal atresia (HP:0011100)1.83708340
96Anophthalmia (HP:0000528)1.83437800
97Anal stenosis (HP:0002025)1.83416830
98Arnold-Chiari malformation (HP:0002308)1.82696599
99Neoplasm of the liver (HP:0002896)1.82581839
100Midline defect of the nose (HP:0004122)1.82265721
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.82155324
102Prolonged partial thromboplastin time (HP:0003645)1.81747101
103Enlarged kidneys (HP:0000105)1.80851640
104Acanthocytosis (HP:0001927)1.80811628
105Choanal stenosis (HP:0000452)1.79589963
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79485499
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78730294
108Overlapping toe (HP:0001845)1.78106597
109Aplasia/Hypoplasia of the macula (HP:0008059)1.75725220
110Bladder carcinoma (HP:0002862)1.75694917
111Bladder neoplasm (HP:0009725)1.75694917
112Proximal placement of thumb (HP:0009623)1.74957791
113Vertebral arch anomaly (HP:0008438)1.74078390
114Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73964851
115Short 1st metacarpal (HP:0010034)1.73964851
116Hyperglycemia (HP:0003074)1.73739501
117Heterotopia (HP:0002282)1.72753106
118Hyperammonemia (HP:0001987)1.71767399
119Hyperacusis (HP:0010780)1.71658142
120Oligodactyly (HP:0012165)1.71559347
121Absent radius (HP:0003974)1.71502551
122Abnormality of serine family amino acid metabolism (HP:0010894)1.70821417
123Abnormality of glycine metabolism (HP:0010895)1.70821417
124Abnormality of the aortic arch (HP:0012303)1.70722696
125Esophageal atresia (HP:0002032)1.69122857
126Hypoalphalipoproteinemia (HP:0003233)1.69104140
127Preaxial foot polydactyly (HP:0001841)1.68700878
128Septo-optic dysplasia (HP:0100842)1.68423823
129Meckel diverticulum (HP:0002245)1.67906709
130Conjugated hyperbilirubinemia (HP:0002908)1.67770514
131Spastic diplegia (HP:0001264)1.67548607
132Hypercholesterolemia (HP:0003124)1.66978393
133Malnutrition (HP:0004395)1.66788786
134Abnormality of the labia majora (HP:0012881)1.66393948
135Abnormality of the calcaneus (HP:0008364)1.65494704
136Pendular nystagmus (HP:0012043)1.65469944
137Duplication of thumb phalanx (HP:0009942)1.65138396
138Supernumerary spleens (HP:0009799)1.64975617
139Broad palm (HP:0001169)1.64763962
140Insomnia (HP:0100785)1.64683205
141Glioma (HP:0009733)1.64635590
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63851212
143Aqueductal stenosis (HP:0002410)1.63793115
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.63509707
145Subacute progressive viral hepatitis (HP:0006572)1.62954445
146Partial duplication of thumb phalanx (HP:0009944)1.62543230
147Curly hair (HP:0002212)1.62427536
148Aplasia involving bones of the upper limbs (HP:0009823)1.62310251
149Aplasia of the phalanges of the hand (HP:0009802)1.62310251
150Aplasia involving bones of the extremities (HP:0009825)1.62310251
151Bicornuate uterus (HP:0000813)1.61966447
152Osteomalacia (HP:0002749)1.61574821
153Atresia of the external auditory canal (HP:0000413)1.60078107
154Upper motor neuron abnormality (HP:0002127)1.59993963
155Facial cleft (HP:0002006)1.59978867
156Hypopigmentation of the fundus (HP:0007894)1.59805831
157High anterior hairline (HP:0009890)1.59737028
158Broad phalanges of the hand (HP:0009768)1.59349992
159Broad finger (HP:0001500)1.58376392
160Abnormality of chromosome segregation (HP:0002916)1.58107129
161Breast carcinoma (HP:0003002)1.57855612
162Coronal craniosynostosis (HP:0004440)1.57687348
163Synostosis of carpal bones (HP:0005048)1.57592436
164Abnormality of the ileum (HP:0001549)1.57481297
165Hemivertebrae (HP:0002937)1.57428302
166Aplasia involving forearm bones (HP:0009822)1.57426743
167Absent forearm bone (HP:0003953)1.57426743
168Renovascular hypertension (HP:0100817)1.57263258
169Cystic hygroma (HP:0000476)1.57164646
170Drooling (HP:0002307)1.56127141
171Cystic liver disease (HP:0006706)1.54550102
172Elfin facies (HP:0004428)1.53664869
173Vertebral clefting (HP:0008428)1.51276142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.99531986
2STK38L4.59368994
3LATS23.66093173
4CDC73.41190198
5MAP3K102.97112662
6CDK122.81715474
7CASK2.72710650
8ERBB42.28261753
9PRKD32.27587617
10MKNK22.26814697
11EEF2K2.26577587
12TTK2.12916062
13NEK22.10778761
14STK32.06784019
15FRK2.03414547
16PBK1.83702849
17ACVR1B1.80374924
18PLK41.77233385
19MAP3K61.74245079
20TSSK61.68311300
21CHEK21.58783041
22TNIK1.57769115
23TRIM281.53411674
24MARK11.50755859
25AKT31.46122027
26NTRK11.37921850
27TAF11.34177352
28FGFR21.24790166
29SRPK11.23763343
30TYRO31.19692420
31ZAK1.19111697
32MELK1.18455828
33PLK11.16791210
34BRD41.14599029
35STK381.12372708
36CHEK11.10003110
37PDGFRA1.09817407
38CDK71.09400516
39PLK31.09163358
40MET1.08115043
41KSR11.07302614
42PDK41.06085078
43PDK31.06085078
44FGFR41.03015757
45ATM1.00368656
46NEK10.98012844
47CAMK1D0.97842837
48WEE10.97541985
49CDK90.96892131
50MAP3K40.93387062
51BUB10.92066252
52MTOR0.91274791
53MAPKAPK30.90587723
54ICK0.90545392
55NTRK20.90283623
56STK240.89959142
57AURKB0.89639671
58RPS6KB20.88671454
59YES10.87934063
60ATR0.85458403
61CDK40.84706532
62RPS6KA40.83610822
63PRKAA10.81695523
64BRAF0.81437912
65CAMK1G0.80711098
66NUAK10.80503548
67WNK30.77850336
68EPHB20.76963228
69SGK20.75611017
70PASK0.74964862
71CSNK1G10.74431245
72CDK80.74071484
73BRSK20.73902681
74KSR20.72000842
75ALK0.71358514
76DYRK20.70471642
77MST1R0.69894154
78SCYL20.68526578
79CDK20.67311641
80PTK20.65912423
81MAP3K80.65689056
82PRKAA20.65534470
83MAPK110.64779028
84TAOK30.64730370
85EPHA40.64558152
86ERBB30.64357834
87TIE10.63856688
88MAPK130.62797206
89CDK180.61371464
90PLK20.60766062
91CDK10.59608207
92AURKA0.59025226
93CDK150.57431496
94PKN20.57426119
95MAP2K70.57165509
96CSNK1A1L0.55745767
97CDK60.54806611
98SGK30.53284397
99EIF2AK10.52606226
100BCR0.52241404
101DDR20.51671533
102MINK10.50020466
103SMG10.49919477
104BRSK10.49351394
105MKNK10.49284611
106CDK11A0.49226408
107PDK20.49055127
108ABL20.48657221
109CSNK1E0.48631459
110CDK140.48447301
111NLK0.48030631
112PRKDC0.48029643
113NEK90.47852091
114TGFBR10.47768941
115PDGFRB0.47358067
116CSNK1G30.46654899
117CSNK1D0.45528690
118NEK60.45388558
119PNCK0.44438575
120CSNK1G20.43608182
121EPHA30.43450289
122MAP3K90.43061908
123DYRK30.42692927
124ERBB20.42390281
125SGK2230.42008511
126SGK4940.42008511
127CLK10.41154924
128FGFR30.40389370
129PTK60.37832316
130MAPK140.36476019
131FGFR10.35719517
132MAP2K40.34814098
133RET0.34607218
134MAPK100.33549987
135EPHA20.32150732
136RPS6KB10.31957539
137GSK3B0.31838396
138TAOK10.31348964

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.52455190
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49508060
3Nitrogen metabolism_Homo sapiens_hsa009102.23516985
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22139191
5Arginine biosynthesis_Homo sapiens_hsa002202.18698328
6Selenocompound metabolism_Homo sapiens_hsa004502.18442891
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12620904
8Cell cycle_Homo sapiens_hsa041102.05434360
9Basal transcription factors_Homo sapiens_hsa030222.03366465
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98195072
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95217373
12Lysine degradation_Homo sapiens_hsa003101.94535510
13Tryptophan metabolism_Homo sapiens_hsa003801.89060618
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87365393
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74078875
16One carbon pool by folate_Homo sapiens_hsa006701.72313580
17Colorectal cancer_Homo sapiens_hsa052101.71877615
18Butanoate metabolism_Homo sapiens_hsa006501.67657348
19Fatty acid degradation_Homo sapiens_hsa000711.63652230
20Wnt signaling pathway_Homo sapiens_hsa043101.62477960
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59256599
22Biosynthesis of amino acids_Homo sapiens_hsa012301.58706818
23Pyruvate metabolism_Homo sapiens_hsa006201.53899260
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.52182102
25RNA transport_Homo sapiens_hsa030131.51818295
26Vitamin B6 metabolism_Homo sapiens_hsa007501.48256947
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47490273
28Propanoate metabolism_Homo sapiens_hsa006401.40774030
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40061014
30Axon guidance_Homo sapiens_hsa043601.39639778
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38656017
32Complement and coagulation cascades_Homo sapiens_hsa046101.34446542
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.32960427
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.32265052
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30641453
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30504759
37Fanconi anemia pathway_Homo sapiens_hsa034601.28572138
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28502227
39PPAR signaling pathway_Homo sapiens_hsa033201.27983932
40TGF-beta signaling pathway_Homo sapiens_hsa043501.26781934
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.26749069
42Fat digestion and absorption_Homo sapiens_hsa049751.26540254
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25530225
44Peroxisome_Homo sapiens_hsa041461.25519489
45Phototransduction_Homo sapiens_hsa047441.23687448
46RNA degradation_Homo sapiens_hsa030181.22712789
47Fatty acid metabolism_Homo sapiens_hsa012121.20384815
48Chronic myeloid leukemia_Homo sapiens_hsa052201.19735430
49mRNA surveillance pathway_Homo sapiens_hsa030151.17643273
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16496356
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15251447
52Bile secretion_Homo sapiens_hsa049761.13846954
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13672099
54Retinol metabolism_Homo sapiens_hsa008301.13508331
55Mismatch repair_Homo sapiens_hsa034301.11418128
56Histidine metabolism_Homo sapiens_hsa003401.09972391
57Tyrosine metabolism_Homo sapiens_hsa003501.09232634
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05585512
59Proteoglycans in cancer_Homo sapiens_hsa052051.04067270
60Sulfur metabolism_Homo sapiens_hsa009201.02913415
61Basal cell carcinoma_Homo sapiens_hsa052171.02635578
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01950830
63Base excision repair_Homo sapiens_hsa034101.01181971
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01003197
65ErbB signaling pathway_Homo sapiens_hsa040121.00674197
66ECM-receptor interaction_Homo sapiens_hsa045121.00488965
67Carbon metabolism_Homo sapiens_hsa012001.00350419
68Folate biosynthesis_Homo sapiens_hsa007900.98838647
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98830038
70Hippo signaling pathway_Homo sapiens_hsa043900.98619121
71Small cell lung cancer_Homo sapiens_hsa052220.96268139
72Melanogenesis_Homo sapiens_hsa049160.95337558
73Chemical carcinogenesis_Homo sapiens_hsa052040.94846427
74Alcoholism_Homo sapiens_hsa050340.92999879
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91035760
76Steroid biosynthesis_Homo sapiens_hsa001000.90393530
77Homologous recombination_Homo sapiens_hsa034400.88681874
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88445850
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88288929
80Glioma_Homo sapiens_hsa052140.87977558
81Adherens junction_Homo sapiens_hsa045200.87136343
82Nucleotide excision repair_Homo sapiens_hsa034200.85874990
83Vitamin digestion and absorption_Homo sapiens_hsa049770.85497569
84Pancreatic cancer_Homo sapiens_hsa052120.85022258
85beta-Alanine metabolism_Homo sapiens_hsa004100.84918259
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.84842946
87Bladder cancer_Homo sapiens_hsa052190.84719402
88MicroRNAs in cancer_Homo sapiens_hsa052060.84247467
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83999300
90Starch and sucrose metabolism_Homo sapiens_hsa005000.83865874
91Hedgehog signaling pathway_Homo sapiens_hsa043400.83741557
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83618277
93p53 signaling pathway_Homo sapiens_hsa041150.83432622
94Arginine and proline metabolism_Homo sapiens_hsa003300.82421297
95Pathways in cancer_Homo sapiens_hsa052000.82325541
96Pentose phosphate pathway_Homo sapiens_hsa000300.81594341
97Melanoma_Homo sapiens_hsa052180.80743288
98Non-small cell lung cancer_Homo sapiens_hsa052230.78944913
99Dorso-ventral axis formation_Homo sapiens_hsa043200.76841298
100DNA replication_Homo sapiens_hsa030300.76675454
101Focal adhesion_Homo sapiens_hsa045100.76134421
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75951194
103Phenylalanine metabolism_Homo sapiens_hsa003600.74408877
104Renal cell carcinoma_Homo sapiens_hsa052110.74212429
105Linoleic acid metabolism_Homo sapiens_hsa005910.73762325
106Gap junction_Homo sapiens_hsa045400.73176577
107Systemic lupus erythematosus_Homo sapiens_hsa053220.71687059
108Non-homologous end-joining_Homo sapiens_hsa034500.71252859
109Oocyte meiosis_Homo sapiens_hsa041140.71056057
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70817543
111Thyroid cancer_Homo sapiens_hsa052160.67871299
112Glutathione metabolism_Homo sapiens_hsa004800.67853597
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66969323
114Ovarian steroidogenesis_Homo sapiens_hsa049130.66055022
115Insulin signaling pathway_Homo sapiens_hsa049100.63700754
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63652779
117AMPK signaling pathway_Homo sapiens_hsa041520.63337112
118Choline metabolism in cancer_Homo sapiens_hsa052310.62941771
119Spliceosome_Homo sapiens_hsa030400.62449143
120Viral carcinogenesis_Homo sapiens_hsa052030.61459896
121Glycerolipid metabolism_Homo sapiens_hsa005610.60347553
122Tight junction_Homo sapiens_hsa045300.56606307
123Endometrial cancer_Homo sapiens_hsa052130.56336142
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55770312
125Rap1 signaling pathway_Homo sapiens_hsa040150.55617711
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53269428
127Caffeine metabolism_Homo sapiens_hsa002320.53037727
128FoxO signaling pathway_Homo sapiens_hsa040680.52074330
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51796528
130Prolactin signaling pathway_Homo sapiens_hsa049170.51305624
131Inositol phosphate metabolism_Homo sapiens_hsa005620.50208925
132ABC transporters_Homo sapiens_hsa020100.49982557
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49862780
134RNA polymerase_Homo sapiens_hsa030200.48442437
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48234655
136N-Glycan biosynthesis_Homo sapiens_hsa005100.46304887
137Fatty acid biosynthesis_Homo sapiens_hsa000610.45072791
138Protein export_Homo sapiens_hsa030600.44578154
139Notch signaling pathway_Homo sapiens_hsa043300.43780176
140Glucagon signaling pathway_Homo sapiens_hsa049220.43756960
141Circadian rhythm_Homo sapiens_hsa047100.43254893
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.42088666
143Thyroid hormone synthesis_Homo sapiens_hsa049180.40572024
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39089167
145Prostate cancer_Homo sapiens_hsa052150.38915660
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.37975970
147Estrogen signaling pathway_Homo sapiens_hsa049150.34357007
148Protein digestion and absorption_Homo sapiens_hsa049740.34087694
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33935685
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33495208

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »