PLEKHA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96109292
2cell communication involved in cardiac conduction (GO:0086065)3.66892896
3cell migration in hindbrain (GO:0021535)3.63129006
4cell communication by electrical coupling (GO:0010644)3.56529675
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53675781
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46422931
7neuronal ion channel clustering (GO:0045161)3.32278828
8synaptic vesicle maturation (GO:0016188)3.24128436
9positive regulation of synapse maturation (GO:0090129)3.20866534
10sodium ion export (GO:0071436)3.17869327
11auditory behavior (GO:0031223)3.15989980
12neuron cell-cell adhesion (GO:0007158)3.15766005
13cerebellar granule cell differentiation (GO:0021707)3.15297024
14lysine metabolic process (GO:0006553)3.15105153
15lysine catabolic process (GO:0006554)3.15105153
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.06873092
17L-phenylalanine catabolic process (GO:0006559)3.06873092
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.06602428
19membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.06518930
20ventricular cardiac muscle cell action potential (GO:0086005)3.01621226
21innervation (GO:0060384)2.99177710
22axonal fasciculation (GO:0007413)2.99040183
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.95926951
24bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94235789
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93188478
26L-phenylalanine metabolic process (GO:0006558)2.93188478
27regulation of neuronal synaptic plasticity (GO:0048168)2.91785385
28dendritic spine organization (GO:0097061)2.89194157
29negative regulation of dendrite morphogenesis (GO:0050774)2.88321653
30vocalization behavior (GO:0071625)2.86559516
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.85261871
32glutamate secretion (GO:0014047)2.83660010
33locomotory exploration behavior (GO:0035641)2.83613577
34cellular potassium ion homeostasis (GO:0030007)2.81589064
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81021094
36neuron recognition (GO:0008038)2.79881823
37embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79358806
38activation of protein kinase A activity (GO:0034199)2.78854651
39synaptic vesicle docking involved in exocytosis (GO:0016081)2.77147399
40postsynaptic membrane organization (GO:0001941)2.76809104
41desmosome organization (GO:0002934)2.76639241
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.75815072
43negative regulation of potassium ion transmembrane transport (GO:1901380)2.75501565
44neurotransmitter secretion (GO:0007269)2.74291768
45membrane repolarization during action potential (GO:0086011)2.72950361
46regulation of heart rate by cardiac conduction (GO:0086091)2.70626347
47dicarboxylic acid biosynthetic process (GO:0043650)2.67531026
48cardiac conduction (GO:0061337)2.66821889
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66132090
50synaptic vesicle endocytosis (GO:0048488)2.65826993
51aspartate family amino acid catabolic process (GO:0009068)2.65133838
52membrane repolarization (GO:0086009)2.64922131
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64791113
54drug catabolic process (GO:0042737)2.64430598
55regulation of synaptic vesicle exocytosis (GO:2000300)2.63430246
56chemosensory behavior (GO:0007635)2.63189738
572-oxoglutarate metabolic process (GO:0006103)2.62945271
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62495680
59regulation of cholesterol homeostasis (GO:2000188)2.62365197
60cell-cell junction maintenance (GO:0045217)2.60965767
61regulation of membrane repolarization (GO:0060306)2.60771123
62positive regulation of potassium ion transmembrane transport (GO:1901381)2.59311990
63synaptic vesicle exocytosis (GO:0016079)2.59063681
64protein localization to synapse (GO:0035418)2.58828994
65apical protein localization (GO:0045176)2.58584299
66membrane depolarization during action potential (GO:0086010)2.58225660
67cellular ketone body metabolic process (GO:0046950)2.58179377
68macroautophagy (GO:0016236)2.57321146
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56823585
70exploration behavior (GO:0035640)2.55609310
71response to auditory stimulus (GO:0010996)2.55032987
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54208243
73kynurenine metabolic process (GO:0070189)2.54057017
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53294003
75alpha-linolenic acid metabolic process (GO:0036109)2.53164802
76potassium ion homeostasis (GO:0055075)2.52915014
77glutamate metabolic process (GO:0006536)2.52756597
78potassium ion import (GO:0010107)2.51860103
79aromatic amino acid family catabolic process (GO:0009074)2.51756002
80neuromuscular synaptic transmission (GO:0007274)2.51518035
81carnitine shuttle (GO:0006853)2.51151819
82detection of calcium ion (GO:0005513)2.50278862
83synaptic transmission, glutamatergic (GO:0035249)2.49904195
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49315970
85axon ensheathment in central nervous system (GO:0032291)2.49214099
86central nervous system myelination (GO:0022010)2.49214099
87relaxation of cardiac muscle (GO:0055119)2.49072107
88neurotransmitter-gated ion channel clustering (GO:0072578)2.49042485
89cell junction maintenance (GO:0034331)2.48475613
90regulation of synapse maturation (GO:0090128)2.48363161
91plasma membrane repair (GO:0001778)2.47547726
92enteric nervous system development (GO:0048484)2.47499214
93mating behavior (GO:0007617)2.47140724
94regulation of synapse structural plasticity (GO:0051823)2.46143601
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45348172
96cochlea development (GO:0090102)2.45006614
97suckling behavior (GO:0001967)2.44593594
98regulation of neurotransmitter levels (GO:0001505)2.44165539
99nucleobase catabolic process (GO:0046113)2.42492052
100dopamine receptor signaling pathway (GO:0007212)2.42339162
101regulation of synaptic vesicle transport (GO:1902803)2.41994874
102gamma-aminobutyric acid transport (GO:0015812)2.41884491
103layer formation in cerebral cortex (GO:0021819)2.41269095
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41156814
105negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.40177206
106drug transmembrane transport (GO:0006855)2.39996749
107neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.39614721
108glutamate receptor signaling pathway (GO:0007215)2.39579548
109cellular sodium ion homeostasis (GO:0006883)2.38146154
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37487314
111exogenous drug catabolic process (GO:0042738)2.36855356
112dendrite morphogenesis (GO:0048813)2.36761666
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36702789
114cardiac muscle contraction (GO:0060048)2.36623741
115pyrimidine nucleobase catabolic process (GO:0006208)2.35649964
116cell differentiation in hindbrain (GO:0021533)2.35518826
117glyoxylate metabolic process (GO:0046487)2.34814435
118positive regulation of membrane potential (GO:0045838)2.33663989
119short-chain fatty acid metabolic process (GO:0046459)2.33648955
120fatty acid transmembrane transport (GO:1902001)2.32790639
121cerebellar Purkinje cell differentiation (GO:0021702)2.32346034
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32288013
123neuromuscular process controlling posture (GO:0050884)2.32081852
124proline transport (GO:0015824)2.31777088
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30648959
126positive regulation of dendritic spine development (GO:0060999)2.30344505
127regulation of bile acid biosynthetic process (GO:0070857)2.30245968
128neuromuscular process controlling balance (GO:0050885)2.29653223
129sulfur amino acid catabolic process (GO:0000098)2.29418787
130sarcomere organization (GO:0045214)2.29337813
131regulation of neurotransmitter secretion (GO:0046928)2.29039508
132synapse assembly (GO:0007416)2.28499050
133positive regulation of potassium ion transport (GO:0043268)2.27233863
134transmission of nerve impulse (GO:0019226)2.26913307
135neuron-neuron synaptic transmission (GO:0007270)2.26664711
136lung epithelium development (GO:0060428)2.26454032
137glycine transport (GO:0015816)2.26166509
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.25715322
139regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.25676186
140multicellular organismal signaling (GO:0035637)2.25567916
141sympathetic nervous system development (GO:0048485)2.25538903
142regulation of glutamate receptor signaling pathway (GO:1900449)2.25494345
143dicarboxylic acid catabolic process (GO:0043649)2.25461724
144cardiac muscle cell action potential involved in contraction (GO:0086002)2.24565556
145protein targeting to Golgi (GO:0000042)2.24262379
146neurotransmitter transport (GO:0006836)2.24182500
147positive regulation of neurotransmitter transport (GO:0051590)2.24115591
148neuron maturation (GO:0042551)2.24027263
149presynaptic membrane organization (GO:0097090)2.23607538
150positive regulation of sodium ion transport (GO:0010765)2.23599957
151regulation of postsynaptic membrane potential (GO:0060078)2.23469574
152cardiac muscle cell action potential (GO:0086001)2.23423652
153regulation of ARF protein signal transduction (GO:0032012)2.23132980
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.22260531
155growth hormone secretion (GO:0030252)2.21609095
156cellular modified amino acid catabolic process (GO:0042219)2.21066844
157regulation of synaptic plasticity (GO:0048167)2.20862553
158behavioral response to nicotine (GO:0035095)2.20828655
159tricarboxylic acid cycle (GO:0006099)2.20403618
160sodium ion homeostasis (GO:0055078)2.20344596
161negative regulation of catenin import into nucleus (GO:0035414)2.19323052
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19178972
163dendritic spine morphogenesis (GO:0060997)2.19126337
164synapse organization (GO:0050808)2.19082811
165regulation of axon extension involved in axon guidance (GO:0048841)2.18365682
166cytoskeletal anchoring at plasma membrane (GO:0007016)2.18095143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80919283
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10698558
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.36641492
4DROSHA_22980978_ChIP-Seq_HELA_Human2.27786606
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16836634
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.08084868
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02048616
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97339435
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95280526
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95268565
11MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90951374
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87173204
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87173204
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85052219
15GBX2_23144817_ChIP-Seq_PC3_Human1.83183572
16REST_21632747_ChIP-Seq_MESCs_Mouse1.82834791
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80979769
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80809979
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76580773
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.75893870
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.73732879
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70720825
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69984049
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68174613
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64070009
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58207816
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.58034155
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.57112301
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54092159
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.52734210
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52455621
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52356638
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.44372760
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44054217
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42776386
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.41969267
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41632722
38* EP300_21415370_ChIP-Seq_HL-1_Mouse1.40815086
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.39615985
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.38357255
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37260012
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.36900746
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36889481
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31684443
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30646843
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28225553
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26106890
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25703748
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24869395
50KDM2B_26808549_Chip-Seq_K562_Human1.23535614
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.23397091
52* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22165098
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.19864504
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17394483
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17162999
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16313059
57ZNF263_19887448_ChIP-Seq_K562_Human1.16125443
58AHR_22903824_ChIP-Seq_MCF-7_Human1.15828366
59ZNF274_21170338_ChIP-Seq_K562_Hela1.14561232
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14379347
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.14043556
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.11992193
63* CTCF_27219007_Chip-Seq_Bcells_Human1.11616653
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10669999
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09842852
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09168085
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08657611
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.07012266
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06998407
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06657838
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04902894
72AR_19668381_ChIP-Seq_PC3_Human1.04397534
73* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04086155
74RACK7_27058665_Chip-Seq_MCF-7_Human1.03534066
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02649068
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02474812
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.01874700
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.00723760
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.00464908
80* ISL1_27105846_Chip-Seq_CPCs_Mouse1.00257365
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99278279
82BCAT_22108803_ChIP-Seq_LS180_Human0.97681680
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97029863
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.95000814
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94332051
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93879678
87LXR_22292898_ChIP-Seq_THP-1_Human0.92697736
88RNF2_27304074_Chip-Seq_NSC_Mouse0.92154275
89* TBX20_22328084_ChIP-Seq_HEART_Mouse0.91881317
90* TBX20_22080862_ChIP-Seq_HEART_Mouse0.91881317
91AR_21572438_ChIP-Seq_LNCaP_Human0.91784156
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91419236
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.91095310
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90306362
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89755805
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89459927
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88924324
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.87361165
99* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87263597
100STAT3_23295773_ChIP-Seq_U87_Human0.85474503
101* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85279790
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84466315
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84339918
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84051044
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83333808
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83181027
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82133364
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82021802
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81639292
110* SMC4_20622854_ChIP-Seq_HELA_Human0.81552603
111KLF5_25053715_ChIP-Seq_YYC3_Human0.81322152
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80905582
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80796617
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80077983
115* CREB1_26743006_Chip-Seq_LNCaP_Human0.79344238
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.79319233
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79251549
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79045999
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.79028523
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78998399
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78109662
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77893719
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77875705
124AR_25329375_ChIP-Seq_VCAP_Human0.76951398
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76303634
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76288934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.60891047
2MP0002139_abnormal_hepatobiliary_system3.40247181
3MP0005360_urolithiasis3.25951833
4MP0004859_abnormal_synaptic_plasticity3.11155987
5MP0005085_abnormal_gallbladder_physiolo2.89950725
6MP0005365_abnormal_bile_salt2.74828421
7MP0004270_analgesia2.59243394
8MP0002909_abnormal_adrenal_gland2.51079683
9MP0009780_abnormal_chondrocyte_physiolo2.38068380
10MP0002822_catalepsy2.31017821
11MP0004043_abnormal_pH_regulation2.25895261
12MP0000751_myopathy2.15638776
13MP0008875_abnormal_xenobiotic_pharmacok2.13429498
14MP0003635_abnormal_synaptic_transmissio2.10609264
15MP0003252_abnormal_bile_duct2.04265532
16MP0000566_synostosis1.98594333
17MP0003880_abnormal_central_pattern1.98512277
18MP0004215_abnormal_myocardial_fiber1.90611784
19MP0003195_calcinosis1.87040947
20MP0003787_abnormal_imprinting1.85575706
21MP0003123_paternal_imprinting1.79656245
22MP0004084_abnormal_cardiac_muscle1.74028300
23MP0003283_abnormal_digestive_organ1.73167637
24MP0004858_abnormal_nervous_system1.73126362
25MP0001968_abnormal_touch/_nociception1.69279846
26MP0002734_abnormal_mechanical_nocicepti1.68951419
27MP0003646_muscle_fatigue1.68591704
28MP0008961_abnormal_basal_metabolism1.68450168
29MP0000778_abnormal_nervous_system1.66326781
30MP0004036_abnormal_muscle_relaxation1.62218027
31MP0005409_darkened_coat_color1.60732716
32MP0009745_abnormal_behavioral_response1.59921453
33MP0010329_abnormal_lipoprotein_level1.58924276
34MP0002063_abnormal_learning/memory/cond1.58660632
35MP0005083_abnormal_biliary_tract1.57488447
36MP0005423_abnormal_somatic_nervous1.54222594
37MP0002638_abnormal_pupillary_reflex1.53490068
38MP0002064_seizures1.51682817
39MP0003329_amyloid_beta_deposits1.50284681
40MP0009046_muscle_twitch1.49320672
41MP0002735_abnormal_chemical_nociception1.48901509
42MP0006276_abnormal_autonomic_nervous1.46843719
43MP0001666_abnormal_nutrient_absorption1.43687286
44MP0002272_abnormal_nervous_system1.38435406
45MP0000534_abnormal_ureter_morphology1.36688646
46MP0002733_abnormal_thermal_nociception1.36605414
47MP0002751_abnormal_autonomic_nervous1.35859908
48MP0005332_abnormal_amino_acid1.35581038
49MP0003137_abnormal_impulse_conducting1.34477442
50MP0004085_abnormal_heartbeat1.34228092
51MP0002572_abnormal_emotion/affect_behav1.33526607
52MP0002249_abnormal_larynx_morphology1.31642184
53MP0010386_abnormal_urinary_bladder1.30670706
54MP0000462_abnormal_digestive_system1.29883491
55MP0001765_abnormal_ion_homeostasis1.28187347
56MP0001664_abnormal_digestion1.27105689
57MP0004130_abnormal_muscle_cell1.25790722
58MP0002882_abnormal_neuron_morphology1.25250021
59MP0010234_abnormal_vibrissa_follicle1.25077527
60MP0001970_abnormal_pain_threshold1.19342890
61MP0002736_abnormal_nociception_after1.16793854
62MP0001501_abnormal_sleep_pattern1.16270692
63MP0005646_abnormal_pituitary_gland1.15656659
64MP0000013_abnormal_adipose_tissue1.15421992
65MP0005330_cardiomyopathy1.14600869
66MP0002118_abnormal_lipid_homeostasis1.13219816
67MP0001486_abnormal_startle_reflex1.13094605
68MP0004264_abnormal_extraembryonic_tissu1.12950383
69MP0004145_abnormal_muscle_electrophysio1.12350197
70MP0002078_abnormal_glucose_homeostasis1.11903969
71MP0005535_abnormal_body_temperature1.10482166
72MP0005187_abnormal_penis_morphology1.08972493
73MP0002972_abnormal_cardiac_muscle1.07308472
74MP0001440_abnormal_grooming_behavior1.06888242
75MP0002876_abnormal_thyroid_physiology1.06100985
76MP0005620_abnormal_muscle_contractility1.03879579
77MP0002067_abnormal_sensory_capabilities1.03500920
78MP0003011_delayed_dark_adaptation1.01830502
79MP0002269_muscular_atrophy1.00810126
80MP0004019_abnormal_vitamin_homeostasis1.00424208
81MP0004924_abnormal_behavior1.00388570
82MP0005386_behavior/neurological_phenoty1.00388570
83MP0005670_abnormal_white_adipose1.00035383
84MP0008775_abnormal_heart_ventricle0.99372995
85MP0008569_lethality_at_weaning0.99158156
86MP0000579_abnormal_nail_morphology0.98824451
87MP0003868_abnormal_feces_composition0.97767974
88MP0001502_abnormal_circadian_rhythm0.96723496
89MP0000749_muscle_degeneration0.96508308
90MP0001984_abnormal_olfaction0.95755636
91MP0001756_abnormal_urination0.94820730
92MP0003879_abnormal_hair_cell0.94670107
93MP0003942_abnormal_urinary_system0.94057398
94MP0003633_abnormal_nervous_system0.93751364
95MP0000230_abnormal_systemic_arterial0.92344277
96MP0000537_abnormal_urethra_morphology0.92300618
97MP0004087_abnormal_muscle_fiber0.91926125
98MP0002557_abnormal_social/conspecific_i0.91445281
99MP0002152_abnormal_brain_morphology0.91026625
100MP0004233_abnormal_muscle_weight0.90959026
101MP0002184_abnormal_innervation0.90554032
102MP0004811_abnormal_neuron_physiology0.89743915
103MP0001944_abnormal_pancreas_morphology0.89458557
104MP0001485_abnormal_pinna_reflex0.87523526
105MP0000955_abnormal_spinal_cord0.87441683
106MP0002234_abnormal_pharynx_morphology0.86591905
107MP0003183_abnormal_peptide_metabolism0.85963823
108MP0004484_altered_response_of0.85760162
109MP0000747_muscle_weakness0.84841369
110MP0003705_abnormal_hypodermis_morpholog0.84409404
111MP0005551_abnormal_eye_electrophysiolog0.83965262
112MP0000538_abnormal_urinary_bladder0.83886066
113MP0001188_hyperpigmentation0.83101609
114MP0009643_abnormal_urine_homeostasis0.82943348
115MP0003953_abnormal_hormone_level0.82614217
116MP0003634_abnormal_glial_cell0.80432356
117MP0003861_abnormal_nervous_system0.79887036
118MP0003122_maternal_imprinting0.79310859
119MP0002069_abnormal_eating/drinking_beha0.78847164
120MP0002752_abnormal_somatic_nervous0.78380790
121MP0002229_neurodegeneration0.77875788
122MP0004885_abnormal_endolymph0.77762944
123MP0008872_abnormal_physiological_respon0.76668688
124MP0002693_abnormal_pancreas_physiology0.76504428
125MP0005448_abnormal_energy_balance0.76264239
126MP0005636_abnormal_mineral_homeostasis0.75650061
127MP0002066_abnormal_motor_capabilities/c0.75298449
128MP0001905_abnormal_dopamine_level0.74930780
129MP0001346_abnormal_lacrimal_gland0.74680620
130MP0005645_abnormal_hypothalamus_physiol0.74614147
131MP0003632_abnormal_nervous_system0.74562615
132MP0002089_abnormal_postnatal_growth/wei0.73326907
133MP0003631_nervous_system_phenotype0.73232461
134MP0005248_abnormal_Harderian_gland0.68848530
135MP0003121_genomic_imprinting0.67185148
136MP0000631_abnormal_neuroendocrine_gland0.67112247
137MP0001348_abnormal_lacrimal_gland0.64887811
138MP0000026_abnormal_inner_ear0.62756024

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)3.77082034
2Ketoacidosis (HP:0001993)3.76195054
3Ventricular fibrillation (HP:0001663)3.68235565
4Syncope (HP:0001279)3.50006339
5Bundle branch block (HP:0011710)3.36719230
6Myokymia (HP:0002411)3.34172970
7Right ventricular cardiomyopathy (HP:0011663)3.31666092
8Ketosis (HP:0001946)3.31519093
9Hypoglycemic coma (HP:0001325)3.23932970
10Hyperinsulinemic hypoglycemia (HP:0000825)3.20849848
11Prolonged QT interval (HP:0001657)3.20647094
12Akinesia (HP:0002304)3.19472593
13Obstructive sleep apnea (HP:0002870)3.04954595
14Gout (HP:0001997)2.97660305
15Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97637857
16Focal motor seizures (HP:0011153)2.91016813
17Intrahepatic cholestasis (HP:0001406)2.86207877
18Febrile seizures (HP:0002373)2.84366937
19Pheochromocytoma (HP:0002666)2.80810624
20Hypoglycemic seizures (HP:0002173)2.74808949
21Visual hallucinations (HP:0002367)2.71790303
22Focal seizures (HP:0007359)2.70367530
23Deep venous thrombosis (HP:0002625)2.66963573
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.66130901
25Hyperparathyroidism (HP:0000843)2.62307333
26Ventricular arrhythmia (HP:0004308)2.60993293
27Palpitations (HP:0001962)2.59954324
28Atrial fibrillation (HP:0005110)2.54865542
29Action tremor (HP:0002345)2.54245630
30Late onset (HP:0003584)2.50100357
31Heart block (HP:0012722)2.48144357
32Abnormal EKG (HP:0003115)2.45933441
33Hypercortisolism (HP:0001578)2.45820805
34Central scotoma (HP:0000603)2.45294500
35Xanthomatosis (HP:0000991)2.43937280
36Ventricular tachycardia (HP:0004756)2.42360871
37Primary atrial arrhythmia (HP:0001692)2.41616787
38Exercise-induced myalgia (HP:0003738)2.39663758
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39026892
40Hyporeflexia of lower limbs (HP:0002600)2.37786518
41Hypoventilation (HP:0002791)2.36356678
42Myoglobinuria (HP:0002913)2.34425299
43Bronchomalacia (HP:0002780)2.33124886
44Atrioventricular block (HP:0001678)2.32490663
45Dysmetric saccades (HP:0000641)2.31565516
46Hyperglycemia (HP:0003074)2.30258769
47Abnormal atrioventricular conduction (HP:0005150)2.26235535
48Conjugated hyperbilirubinemia (HP:0002908)2.25673185
49Amblyopia (HP:0000646)2.24948936
50Supraventricular tachycardia (HP:0004755)2.24503891
51Neuroendocrine neoplasm (HP:0100634)2.24471716
52Hyperammonemia (HP:0001987)2.21310806
53Supraventricular arrhythmia (HP:0005115)2.18403386
54Symptomatic seizures (HP:0011145)2.18087758
55Sleep apnea (HP:0010535)2.17282207
56Hyperglycinuria (HP:0003108)2.16744746
57Shawl scrotum (HP:0000049)2.16203589
58Hyperactive renin-angiotensin system (HP:0000841)2.13992996
59Fetal akinesia sequence (HP:0001989)2.13579056
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13422405
61Skin nodule (HP:0200036)2.12866738
62Increased circulating renin level (HP:0000848)2.11302048
63Agitation (HP:0000713)2.10683844
64Supranuclear gaze palsy (HP:0000605)2.09937181
65Abnormal social behavior (HP:0012433)2.09095695
66Impaired social interactions (HP:0000735)2.09095695
67Bicornuate uterus (HP:0000813)2.07639568
68Adrenal overactivity (HP:0002717)2.04659087
69Neurofibrillary tangles (HP:0002185)2.02452084
70Calf muscle hypertrophy (HP:0008981)2.02435114
71Abnormal pancreas size (HP:0012094)2.01339353
72Abnormality of the lower motor neuron (HP:0002366)2.01276257
73Limb dystonia (HP:0002451)2.00159735
74Decreased circulating renin level (HP:0003351)1.99366803
75Abnormality of the aortic arch (HP:0012303)1.98382072
76Generalized tonic-clonic seizures (HP:0002069)1.97931880
77Depression (HP:0000716)1.97458800
78Abnormality of renin-angiotensin system (HP:0000847)1.96989448
79Turricephaly (HP:0000262)1.96740390
80Progressive cerebellar ataxia (HP:0002073)1.95934359
81Hyperventilation (HP:0002883)1.94029823
82Hyperglycinemia (HP:0002154)1.93986768
83Hyperacusis (HP:0010780)1.93367228
84Metabolic alkalosis (HP:0200114)1.93270042
85Genetic anticipation (HP:0003743)1.92768192
86Abnormality of glycine metabolism (HP:0010895)1.92656366
87Abnormality of serine family amino acid metabolism (HP:0010894)1.92656366
88Abnormality of the parathyroid morphology (HP:0011766)1.92333633
89Anxiety (HP:0000739)1.91858473
90Status epilepticus (HP:0002133)1.91567966
91Postural instability (HP:0002172)1.90801705
92Urinary bladder sphincter dysfunction (HP:0002839)1.90576876
93Pancreatic islet-cell hyperplasia (HP:0004510)1.90299641
94Abnormality of purine metabolism (HP:0004352)1.90113687
95Hyperphosphatemia (HP:0002905)1.88252427
96Neoplasm of the heart (HP:0100544)1.87892419
97Abnormality of endocrine pancreas physiology (HP:0012093)1.87423560
98Abnormality of the pancreatic islet cells (HP:0006476)1.87423560
99Absence seizures (HP:0002121)1.87242489
100Torticollis (HP:0000473)1.86238711
101Neonatal onset (HP:0003623)1.83943299
102Epidermoid cyst (HP:0200040)1.83894775
103Visceral angiomatosis (HP:0100761)1.83891057
104Abnormal eating behavior (HP:0100738)1.83855782
105Asymmetric septal hypertrophy (HP:0001670)1.83458173
106Ankle clonus (HP:0011448)1.81518112
107EEG with generalized epileptiform discharges (HP:0011198)1.81459237
108Spastic gait (HP:0002064)1.80369210
109Hypsarrhythmia (HP:0002521)1.78925802
110Macroorchidism (HP:0000053)1.78850747
111Annular pancreas (HP:0001734)1.78807765
112Complement deficiency (HP:0004431)1.78207603
113Lymphangioma (HP:0100764)1.77953786
114Dysdiadochokinesis (HP:0002075)1.77862929
115Abnormality of the calf musculature (HP:0001430)1.76360159
116Aplasia involving bones of the upper limbs (HP:0009823)1.76283969
117Aplasia of the phalanges of the hand (HP:0009802)1.76283969
118Aplasia involving bones of the extremities (HP:0009825)1.76283969
119Epileptiform EEG discharges (HP:0011182)1.76250731
120Atonic seizures (HP:0010819)1.75436579
121Myotonia (HP:0002486)1.75349044
122Poor eye contact (HP:0000817)1.74905356
123Prolonged partial thromboplastin time (HP:0003645)1.74529788
124Alkalosis (HP:0001948)1.74526449
125Epileptic encephalopathy (HP:0200134)1.74198126
126Hyperlipoproteinemia (HP:0010980)1.73703537
127Failure to thrive in infancy (HP:0001531)1.73435947
128Abnormality of calcium-phosphate metabolism (HP:0100530)1.72683987
129Shallow orbits (HP:0000586)1.72279853
130Muscle hypertrophy of the lower extremities (HP:0008968)1.72067240
131Exotropia (HP:0000577)1.71489801
132Diminished movement (HP:0002374)1.70942339
133Bowel diverticulosis (HP:0005222)1.70188368
134Impaired vibration sensation in the lower limbs (HP:0002166)1.70158522
135Abnormality of pain sensation (HP:0010832)1.69835219
136Impaired pain sensation (HP:0007328)1.69835219
137Distal upper limb amyotrophy (HP:0007149)1.69727443
138Upper limb amyotrophy (HP:0009129)1.69727443
139Hypercalciuria (HP:0002150)1.69458882
140Potter facies (HP:0002009)1.69189755
141Facial shape deformation (HP:0011334)1.69189755
142Dysmetria (HP:0001310)1.68441908
143Abnormality of fatty-acid metabolism (HP:0004359)1.68179539
144Lower limb amyotrophy (HP:0007210)1.66675325
145Intention tremor (HP:0002080)1.66029380
146Cerebral inclusion bodies (HP:0100314)1.64538962
147Germ cell neoplasia (HP:0100728)1.63530677
148Hyperaldosteronism (HP:0000859)1.63497368
149Buphthalmos (HP:0000557)1.63279457
150Papilledema (HP:0001085)1.61993233
151Hemangiomatosis (HP:0007461)1.60039165
152Enlarged penis (HP:0000040)1.56540977
153Hypercalcemia (HP:0003072)1.56459585
154Growth hormone excess (HP:0000845)1.56224610
155Dialeptic seizures (HP:0011146)1.53876125
156Polyphagia (HP:0002591)1.53790448
157Renovascular hypertension (HP:0100817)1.52070225
158Cerebral aneurysm (HP:0004944)1.51598957
159Focal dystonia (HP:0004373)1.51530861
160Popliteal pterygium (HP:0009756)1.50870969
161Hypothermia (HP:0002045)1.50234959
162Clonus (HP:0002169)1.50084976
163Truncal ataxia (HP:0002078)1.49444197
164Insomnia (HP:0100785)1.49180896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.28600565
2LMTK22.92660543
3CASK2.91814664
4NTRK32.89068348
5MAP3K92.57761079
6INSRR2.56965694
7PRKD32.28952021
8MAP3K42.07985032
9WNK42.05450484
10DAPK22.00687614
11NTRK11.99618521
12MUSK1.98960999
13PHKG21.84159526
14PHKG11.84159526
15EPHA41.83974878
16KSR21.82092068
17MAP3K21.80788948
18STK381.79665668
19MAP2K41.78988651
20CAMKK11.75308137
21RIPK11.68686862
22MINK11.65076183
23FGFR21.62753698
24PAK61.62284450
25TRIB31.56210844
26MARK11.54968929
27BCKDK1.51129379
28MET1.45501947
29SIK11.44535488
30PAK31.42540162
31CDC42BPA1.31562143
32FRK1.27844280
33WNK31.24275591
34PINK11.22841346
35PDK41.21541583
36PDK31.21541583
37MYLK1.19419237
38RET1.18671840
39PKN21.16873807
40MAP2K71.14225718
41WNK11.13521754
42PDGFRA1.10601116
43SGK2231.07909918
44SGK4941.07909918
45MAP3K11.04203863
46FER1.04037403
47DMPK1.02170034
48TAOK31.01367748
49CAMK2B0.99617713
50MAP3K70.99531466
51SGK30.99211400
52NTRK20.97396963
53UHMK10.96432054
54CDK50.96095498
55CAMK1G0.94027118
56PRKAA10.92761589
57ERN10.92732264
58PRKCH0.92426098
59KSR10.91807806
60NEK10.90739011
61SGK20.90212158
62AKT30.88202077
63CAMK2D0.86451327
64TESK10.85835643
65GRK50.85140921
66PTK20.83526104
67TTN0.82035115
68TAOK10.78908982
69DDR20.78802018
70OXSR10.78483117
71CAMKK20.77554269
72ICK0.76607900
73LATS20.75615616
74ERBB20.75184179
75OBSCN0.75127788
76PTK60.74691498
77FGFR40.74197693
78MST1R0.73317827
79CAMK2A0.71425978
80RPS6KA20.71268486
81PDPK10.69195128
82ROCK10.68062635
83NEK60.66940989
84STK110.66386276
85DYRK1B0.66033661
86CAMK10.65915371
87PRKCG0.65687760
88MTOR0.65641922
89MAP2K10.65613268
90STK390.65222396
91DYRK1A0.64268440
92PNCK0.63608517
93PRKCZ0.63156353
94SIK20.62844348
95PRKD10.62075296
96MARK20.61578422
97PIK3CA0.60467970
98PRKG20.59870420
99CAMK2G0.59841553
100EPHB20.58417261
101CAMK40.57663762
102CDK150.55966827
103PRKACG0.55289290
104TYRO30.55183232
105PRKAA20.53949398
106PDK10.53925113
107CDK180.53450734
108MAPK130.52994018
109CAMK1D0.52500287
110SGK10.52305232
111HIPK20.50463309
112CDK11A0.48570553
113RPS6KA30.48117957
114PDGFRB0.47916838
115DYRK20.47910801
116PDK20.47489816
117EEF2K0.47451597
118PRKCE0.46164739
119DAPK10.45606395
120ALK0.45145257
121ROCK20.44611309
122PRKCI0.44310103
123MAPK150.44116676
124MAPK80.44099832
125CDK140.43681075
126EPHA30.43265178

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69713494
2Nitrogen metabolism_Homo sapiens_hsa009102.64673415
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01510813
4Arginine biosynthesis_Homo sapiens_hsa002201.98952782
5Maturity onset diabetes of the young_Homo sapiens_hsa049501.95540604
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86955991
7Butanoate metabolism_Homo sapiens_hsa006501.84602447
8Insulin secretion_Homo sapiens_hsa049111.82715912
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.80881330
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72601904
11Bile secretion_Homo sapiens_hsa049761.71492070
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69707570
13Fatty acid degradation_Homo sapiens_hsa000711.68338436
14Tryptophan metabolism_Homo sapiens_hsa003801.64029804
15Synaptic vesicle cycle_Homo sapiens_hsa047211.61602453
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52764809
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45984280
18Propanoate metabolism_Homo sapiens_hsa006401.45471761
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.40069573
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37343412
21Axon guidance_Homo sapiens_hsa043601.36525630
22Type II diabetes mellitus_Homo sapiens_hsa049301.36505990
23Circadian entrainment_Homo sapiens_hsa047131.35385286
24GABAergic synapse_Homo sapiens_hsa047271.33810646
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30481833
26Fatty acid metabolism_Homo sapiens_hsa012121.26185047
27Sulfur metabolism_Homo sapiens_hsa009201.26055351
28Nicotine addiction_Homo sapiens_hsa050331.24211178
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21298254
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21271270
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18310794
32Gastric acid secretion_Homo sapiens_hsa049711.17157341
33Cardiac muscle contraction_Homo sapiens_hsa042601.16586063
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16046034
35PPAR signaling pathway_Homo sapiens_hsa033201.13621940
36Amphetamine addiction_Homo sapiens_hsa050311.13126508
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12311709
38Olfactory transduction_Homo sapiens_hsa047401.10838720
39Pyruvate metabolism_Homo sapiens_hsa006201.10814312
40Salivary secretion_Homo sapiens_hsa049701.10512889
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08512723
42Glutamatergic synapse_Homo sapiens_hsa047241.07883113
43Long-term potentiation_Homo sapiens_hsa047201.05298484
44Taste transduction_Homo sapiens_hsa047421.00370483
45Tight junction_Homo sapiens_hsa045300.99920946
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99895586
47Dopaminergic synapse_Homo sapiens_hsa047280.99764112
48Dilated cardiomyopathy_Homo sapiens_hsa054140.99073750
49Starch and sucrose metabolism_Homo sapiens_hsa005000.98055766
50Morphine addiction_Homo sapiens_hsa050320.97365823
51Cocaine addiction_Homo sapiens_hsa050300.97125097
52Retinol metabolism_Homo sapiens_hsa008300.96930979
53Cholinergic synapse_Homo sapiens_hsa047250.95984166
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94111761
55Renin secretion_Homo sapiens_hsa049240.93649161
56Vitamin B6 metabolism_Homo sapiens_hsa007500.93509954
57Phenylalanine metabolism_Homo sapiens_hsa003600.92712177
58Melanogenesis_Homo sapiens_hsa049160.91359885
59Fat digestion and absorption_Homo sapiens_hsa049750.90390275
60ABC transporters_Homo sapiens_hsa020100.89663863
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.89628959
62Glucagon signaling pathway_Homo sapiens_hsa049220.89459513
63Ovarian steroidogenesis_Homo sapiens_hsa049130.86668209
64Carbon metabolism_Homo sapiens_hsa012000.84332951
65Peroxisome_Homo sapiens_hsa041460.83076294
66beta-Alanine metabolism_Homo sapiens_hsa004100.82825885
67Pancreatic secretion_Homo sapiens_hsa049720.82747365
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81816888
69Thyroid hormone synthesis_Homo sapiens_hsa049180.78026263
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77511983
71ErbB signaling pathway_Homo sapiens_hsa040120.76197955
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76188781
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74857720
74Insulin resistance_Homo sapiens_hsa049310.74213079
75Lysine degradation_Homo sapiens_hsa003100.73738922
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73486421
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71897977
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71813936
79Oxytocin signaling pathway_Homo sapiens_hsa049210.71480964
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69686313
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68971187
82Calcium signaling pathway_Homo sapiens_hsa040200.68945190
83cAMP signaling pathway_Homo sapiens_hsa040240.67727558
84Glycerolipid metabolism_Homo sapiens_hsa005610.66978731
85GnRH signaling pathway_Homo sapiens_hsa049120.66701769
86Dorso-ventral axis formation_Homo sapiens_hsa043200.66257654
87Complement and coagulation cascades_Homo sapiens_hsa046100.65823416
88Histidine metabolism_Homo sapiens_hsa003400.65134865
89Inositol phosphate metabolism_Homo sapiens_hsa005620.64169749
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63998344
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.63268343
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62949340
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61857385
94Estrogen signaling pathway_Homo sapiens_hsa049150.61690104
95Fatty acid biosynthesis_Homo sapiens_hsa000610.61476863
96Hippo signaling pathway_Homo sapiens_hsa043900.60606650
97Glioma_Homo sapiens_hsa052140.59743169
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.59357580
99Insulin signaling pathway_Homo sapiens_hsa049100.59322788
100Circadian rhythm_Homo sapiens_hsa047100.59211161
101Gap junction_Homo sapiens_hsa045400.58568157
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58413319
103Collecting duct acid secretion_Homo sapiens_hsa049660.57896084
104Tyrosine metabolism_Homo sapiens_hsa003500.56873966
105Notch signaling pathway_Homo sapiens_hsa043300.55765063
106Protein digestion and absorption_Homo sapiens_hsa049740.53159491
107Serotonergic synapse_Homo sapiens_hsa047260.52704654
108Biosynthesis of amino acids_Homo sapiens_hsa012300.52655961
109Caffeine metabolism_Homo sapiens_hsa002320.51244547
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49821717
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49598900
112Rap1 signaling pathway_Homo sapiens_hsa040150.49477684
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49395076
114Endometrial cancer_Homo sapiens_hsa052130.48543893
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47205575
116Long-term depression_Homo sapiens_hsa047300.47079674
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.46959599
118Mineral absorption_Homo sapiens_hsa049780.46842210
119Fructose and mannose metabolism_Homo sapiens_hsa000510.46265597
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46152608
121Chemical carcinogenesis_Homo sapiens_hsa052040.45893844
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44811598
123AMPK signaling pathway_Homo sapiens_hsa041520.43860575
124Arginine and proline metabolism_Homo sapiens_hsa003300.43200003
125Vibrio cholerae infection_Homo sapiens_hsa051100.42220317

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