PLEK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.79691455
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.79691455
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.79691455
4modulation by symbiont of host immune response (GO:0052553)6.79691455
5positive regulation by symbiont of host defense response (GO:0052509)6.79691455
6modulation by symbiont of host defense response (GO:0052031)6.79691455
7response to peptidoglycan (GO:0032494)5.46439232
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41925404
9neutrophil activation involved in immune response (GO:0002283)5.37871708
10macrophage activation involved in immune response (GO:0002281)5.01555699
11regulation of interferon-beta biosynthetic process (GO:0045357)4.51186700
12response to host immune response (GO:0052572)4.49661281
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.49661281
14positive regulation of interferon-alpha production (GO:0032727)4.48630995
15regulation of interferon-alpha production (GO:0032647)4.30406102
16microglial cell activation (GO:0001774)4.29346159
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28257296
18negative regulation of cell killing (GO:0031342)4.28257296
19positive regulation of chemokine biosynthetic process (GO:0045080)4.21921315
20lipopolysaccharide-mediated signaling pathway (GO:0031663)4.21784719
21immunoglobulin mediated immune response (GO:0016064)4.16653933
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.15908166
23response to host (GO:0075136)4.09225980
24response to host defenses (GO:0052200)4.09225980
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.09225980
26respiratory burst (GO:0045730)4.07561182
27detection of other organism (GO:0098543)4.07196375
28granulocyte activation (GO:0036230)4.02354552
29response to muramyl dipeptide (GO:0032495)3.97064546
30positive regulation of heat generation (GO:0031652)3.88172562
31neutrophil activation (GO:0042119)3.85950751
32antigen processing and presentation of endogenous antigen (GO:0019883)3.84293376
33regulation of gamma-delta T cell activation (GO:0046643)3.83514904
34positive regulation of gamma-delta T cell activation (GO:0046645)3.82139620
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.79806886
36myeloid cell activation involved in immune response (GO:0002275)3.78097308
37hydrogen peroxide biosynthetic process (GO:0050665)3.75486181
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73936074
39detection of bacterium (GO:0016045)3.73194290
40regulation of fever generation (GO:0031620)3.66006885
41negative regulation of interleukin-12 production (GO:0032695)3.62166451
42positive regulation of cellular amide metabolic process (GO:0034250)3.59660897
43negative regulation of interleukin-17 production (GO:0032700)3.57192643
44detection of molecule of bacterial origin (GO:0032490)3.56157182
45macrophage activation (GO:0042116)3.54171027
46detection of external biotic stimulus (GO:0098581)3.53502913
47superoxide anion generation (GO:0042554)3.52167499
48natural killer cell mediated cytotoxicity (GO:0042267)3.50334684
49natural killer cell mediated immunity (GO:0002228)3.50334684
50regulation of B cell receptor signaling pathway (GO:0050855)3.46960898
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45780603
52production of molecular mediator involved in inflammatory response (GO:0002532)3.45206755
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44786654
54positive regulation of interferon-beta production (GO:0032728)3.42543076
55regulation of chemokine biosynthetic process (GO:0045073)3.42143675
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.40438752
57positive regulation of mast cell degranulation (GO:0043306)3.40438752
58leukocyte aggregation (GO:0070486)3.39839839
59regulation of interleukin-12 biosynthetic process (GO:0045075)3.39601290
60positive regulation of antigen processing and presentation (GO:0002579)3.36362964
61reactive oxygen species biosynthetic process (GO:1903409)3.34995884
62response to protozoan (GO:0001562)3.34723042
63regulation of mast cell degranulation (GO:0043304)3.33930859
64positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.31284593
65B cell receptor signaling pathway (GO:0050853)3.31068536
66positive regulation of mast cell activation (GO:0033005)3.27475535
67T cell migration (GO:0072678)3.24418455
68cellular extravasation (GO:0045123)3.23940560
69positive regulation of interleukin-12 production (GO:0032735)3.23321975
70defense response to protozoan (GO:0042832)3.22813832
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.22526456
72neutrophil mediated immunity (GO:0002446)3.22169070
73cytokine secretion (GO:0050663)3.21859927
74I-kappaB phosphorylation (GO:0007252)3.20790951
75regulation of mononuclear cell migration (GO:0071675)3.19305850
76regulation of T-helper 1 cell differentiation (GO:0045625)3.18467192
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18194312
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16462831
79positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.15936260
80regulation of gamma-delta T cell differentiation (GO:0045586)3.15383331
81regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.14869692
82regulation of mast cell activation involved in immune response (GO:0033006)3.12177865
83germinal center formation (GO:0002467)3.09187412
84negative regulation of erythrocyte differentiation (GO:0045647)3.08098419
85interferon-gamma-mediated signaling pathway (GO:0060333)3.07948154
86positive regulation of B cell differentiation (GO:0045579)3.07718812
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07488985
88cellular response to type I interferon (GO:0071357)3.07282773
89type I interferon signaling pathway (GO:0060337)3.07282773
90regulation of B cell differentiation (GO:0045577)3.07137652
91regulation of mast cell activation (GO:0033003)3.07120363
92leukocyte mediated cytotoxicity (GO:0001909)3.05110860
93response to type I interferon (GO:0034340)3.04800468
94positive regulation of chemokine production (GO:0032722)3.04638312
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02633813
96negative regulation of T cell mediated immunity (GO:0002710)3.02078960
97positive regulation of type 2 immune response (GO:0002830)3.01715903
98myeloid dendritic cell differentiation (GO:0043011)3.01334427
99B cell mediated immunity (GO:0019724)3.00813204
100positive regulation of NF-kappaB import into nucleus (GO:0042346)3.00685338
101regulation of interleukin-8 biosynthetic process (GO:0045414)3.00057327
102regulation of interleukin-17 production (GO:0032660)2.99905226
103negative regulation of lymphocyte mediated immunity (GO:0002707)2.99735370
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97918573
105cellular response to interferon-beta (GO:0035458)2.97241275
106myeloid dendritic cell activation (GO:0001773)2.96666040
107myeloid leukocyte activation (GO:0002274)2.95841508
108positive regulation of interleukin-1 beta secretion (GO:0050718)2.95622456
109regulation of interleukin-12 production (GO:0032655)2.95142078
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94340668
111regulation of leukocyte degranulation (GO:0043300)2.92507068
112NIK/NF-kappaB signaling (GO:0038061)2.91831735
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91564965
114positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.91104713
115positive regulation of cytokine biosynthetic process (GO:0042108)2.90920756
116positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.89942179
117eosinophil chemotaxis (GO:0048245)2.88616823
118regulation of heat generation (GO:0031650)2.87548420
119leukocyte cell-cell adhesion (GO:0007159)2.87519053
120regulation of antigen processing and presentation (GO:0002577)2.87241034
121neutrophil chemotaxis (GO:0030593)2.85844245
122detection of biotic stimulus (GO:0009595)2.85625570
123regulation of T-helper 2 cell differentiation (GO:0045628)2.85504668
124T-helper 1 type immune response (GO:0042088)2.85324619
125cellular response to exogenous dsRNA (GO:0071360)2.84927411
126positive regulation of macrophage cytokine production (GO:0060907)2.83933229
127cellular response to interferon-gamma (GO:0071346)2.82520784
128negative regulation of cytokine production involved in immune response (GO:0002719)2.82417907
129positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.82257015
130positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.80329266
131regulation of vitamin D biosynthetic process (GO:0060556)2.79852631
132myeloid leukocyte mediated immunity (GO:0002444)2.79243418
133regulation of tolerance induction (GO:0002643)2.79026349
134regulation of alpha-beta T cell proliferation (GO:0046640)2.78228929
135leukocyte degranulation (GO:0043299)2.77254218
136positive regulation of interleukin-10 production (GO:0032733)2.76911428
137negative regulation of leukocyte mediated immunity (GO:0002704)2.76121125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.45028239
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.74389768
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.63011094
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.56230502
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.38808510
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04039280
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84675424
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.84168347
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.79997525
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57975325
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49294215
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.49101562
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.33295882
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.13909421
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.06773828
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.00702006
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73770081
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52203571
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32461668
20* SPI1_23547873_ChIP-Seq_NB4_Human2.21431872
21* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19186074
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18272965
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.15969159
24MYC_22102868_ChIP-Seq_BL_Human2.07257419
25* SCL_19346495_ChIP-Seq_HPC-7_Human2.04090916
26RUNX_20019798_ChIP-Seq_JUKART_Human1.95931628
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94288580
28PU_27001747_Chip-Seq_BMDM_Mouse1.87592732
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.85157305
30* VDR_24763502_ChIP-Seq_THP-1_Human1.83964047
31SPI1_23127762_ChIP-Seq_K562_Human1.83285771
32MYB_26560356_Chip-Seq_TH2_Human1.81687741
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79625960
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77802654
35* VDR_24787735_ChIP-Seq_THP-1_Human1.72006284
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68131362
37* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67044027
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66529643
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62385635
40* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59764297
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59568512
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54316503
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.47363501
44* MAF_26560356_Chip-Seq_TH1_Human1.46425098
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46393803
46MYB_26560356_Chip-Seq_TH1_Human1.46356483
47VDR_21846776_ChIP-Seq_THP-1_Human1.38379284
48* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38091955
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.32816084
50* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32637855
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32229926
52* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30934859
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29264317
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24521763
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22566602
56GATA3_27048872_Chip-Seq_THYMUS_Human1.22136084
57* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20736602
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20281853
59GATA3_26560356_Chip-Seq_TH2_Human1.20191107
60* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19610028
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16970114
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16356160
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15283810
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14258768
65KDM2B_26808549_Chip-Seq_DND41_Human1.12546720
66GATA1_22025678_ChIP-Seq_K562_Human1.10671374
67* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08430434
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08090907
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06668843
70* UTX_26944678_Chip-Seq_JUKART_Human1.04457320
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02363457
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99312167
73TCF7_22412390_ChIP-Seq_EML_Mouse0.96446786
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96069567
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94681212
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91947933
77NCOR1_26117541_ChIP-Seq_K562_Human0.89255389
78* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86949341
79BCL6_27268052_Chip-Seq_Bcells_Human0.85533657
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83899292
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83068602
82* GATA1_19941827_ChIP-Seq_MEL_Mouse0.82377285
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81773634
84RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81198451
85GATA2_19941826_ChIP-Seq_K562_Human0.79854517
86LXR_22292898_ChIP-Seq_THP-1_Human0.78483790
87TFEB_21752829_ChIP-Seq_HELA_Human0.78391650
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78286487
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77542036
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76786427
91BCOR_27268052_Chip-Seq_Bcells_Human0.76058084
92* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75803185
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75737987
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75730558
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.74460802
96* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73806353
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71545759
98MAF_26560356_Chip-Seq_TH2_Human0.71407443
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70060342
100SMRT_27268052_Chip-Seq_Bcells_Human0.67925189
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67805104
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67805104
103GATA1_19941826_ChIP-Seq_K562_Human0.67605381
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.67052986
105SPI1_20517297_ChIP-Seq_HL60_Human0.67038054
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.66978510
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65944155
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64886445
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63708904
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62792832
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62584086
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62584086
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.62571630
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60828319
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60705839
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.60496733
117EGR1_19032775_ChIP-ChIP_M12_Human0.60332138
118SOX2_20726797_ChIP-Seq_SW620_Human0.59933806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.49631964
2MP0003436_decreased_susceptibility_to3.89036610
3MP0009785_altered_susceptibility_to3.72760629
4MP0003303_peritoneal_inflammation3.51280473
5MP0002148_abnormal_hypersensitivity_rea3.50233183
6MP0002419_abnormal_innate_immunity3.40582513
7MP0005000_abnormal_immune_tolerance3.34850228
8MP0006082_CNS_inflammation3.23908898
9MP0003724_increased_susceptibility_to3.07001043
10MP0005025_abnormal_response_to3.04200794
11MP0005387_immune_system_phenotype2.86402380
12MP0001790_abnormal_immune_system2.86402380
13MP0002452_abnormal_antigen_presenting2.83256436
14MP0005058_abnormal_lysosome_morphology2.81117085
15MP0001800_abnormal_humoral_immune2.71509982
16MP0002723_abnormal_immune_serum2.65115199
17MP0005671_abnormal_response_to2.65059711
18MP0000685_abnormal_immune_system2.59025182
19MP0004510_myositis2.45428081
20MP0000569_abnormal_digit_pigmentation2.45251882
21MP0001819_abnormal_immune_cell2.37541543
22MP0002420_abnormal_adaptive_immunity2.35151822
23MP0003172_abnormal_lysosome_physiology2.21716247
24MP0009278_abnormal_bone_marrow2.19543272
25* MP0005464_abnormal_platelet_physiology2.17666023
26MP0004947_skin_inflammation2.11424157
27MP0001533_abnormal_skeleton_physiology2.07118467
28MP0001853_heart_inflammation1.97790369
29MP0009764_decreased_sensitivity_to1.93275337
30MP0002405_respiratory_system_inflammati1.92980717
31MP0001845_abnormal_inflammatory_respons1.91762504
32MP0003448_altered_tumor_morphology1.85709743
33MP0002006_tumorigenesis1.77890193
34MP0008469_abnormal_protein_level1.68850657
35MP0000716_abnormal_immune_system1.68556053
36MP0000343_altered_response_to1.66163239
37MP0003075_altered_response_to1.64200757
38MP0010155_abnormal_intestine_physiology1.61248501
39* MP0002398_abnormal_bone_marrow1.59935796
40MP0003191_abnormal_cellular_cholesterol1.59375626
41MP0001545_abnormal_hematopoietic_system1.55088470
42MP0005397_hematopoietic_system_phenotyp1.55088470
43MP0000858_altered_metastatic_potential1.47745237
44MP0009333_abnormal_splenocyte_physiolog1.45386773
45MP0005310_abnormal_salivary_gland1.43115655
46MP0005451_abnormal_body_composition1.42041016
47MP0003300_gastrointestinal_ulcer1.41672355
48MP0000689_abnormal_spleen_morphology1.41074410
49MP0002998_abnormal_bone_remodeling1.39445155
50MP0005174_abnormal_tail_pigmentation1.38462551
51MP0005167_abnormal_blood-brain_barrier1.33977732
52* MP0002429_abnormal_blood_cell1.33936124
53MP0003183_abnormal_peptide_metabolism1.29927598
54MP0009840_abnormal_foam_cell1.28035193
55MP0000604_amyloidosis1.27391880
56MP0002722_abnormal_immune_system1.26222514
57MP0005166_decreased_susceptibility_to1.24887663
58MP0003828_pulmonary_edema1.22176301
59MP0002166_altered_tumor_susceptibility1.17353513
60MP0003690_abnormal_glial_cell1.14181317
61MP0002254_reproductive_system_inflammat1.12960317
62MP0002132_abnormal_respiratory_system1.12561365
63MP0002933_joint_inflammation1.06754719
64MP0003806_abnormal_nucleotide_metabolis1.06719865
65MP0001851_eye_inflammation1.04166996
66MP0005164_abnormal_response_to1.02053335
67MP0009763_increased_sensitivity_to1.00894374
68MP0010307_abnormal_tumor_latency0.99457129
69MP0002277_abnormal_respiratory_mucosa0.98397090
70MP0005076_abnormal_cell_differentiation0.98115557
71MP0005390_skeleton_phenotype0.96818228
72MP0000371_diluted_coat_color0.92854659
73MP0008260_abnormal_autophagy0.89887415
74MP0000015_abnormal_ear_pigmentation0.88899794
75MP0003763_abnormal_thymus_physiology0.87782063
76MP0000465_gastrointestinal_hemorrhage0.85099770
77MP0009765_abnormal_xenobiotic_induced0.85038461
78MP0003566_abnormal_cell_adhesion0.84625355
79MP0003453_abnormal_keratinocyte_physiol0.84510783
80MP0000249_abnormal_blood_vessel0.83589305
81MP0001663_abnormal_digestive_system0.83314882
82MP0003656_abnormal_erythrocyte_physiolo0.83091637
83MP0001873_stomach_inflammation0.82656925
84MP0002139_abnormal_hepatobiliary_system0.82055728
85MP0002396_abnormal_hematopoietic_system0.81733478
86MP0004808_abnormal_hematopoietic_stem0.78856479
87MP0010352_gastrointestinal_tract_polyps0.77635146
88MP0004782_abnormal_surfactant_physiolog0.74439415
89MP0002138_abnormal_hepatobiliary_system0.73949108
90MP0004883_abnormal_blood_vessel0.69783479
91MP0003091_abnormal_cell_migration0.69428383
92MP0008874_decreased_physiological_sensi0.69195828
93MP0003186_abnormal_redox_activity0.67619403
94MP0005257_abnormal_intraocular_pressure0.65885271
95MP0000490_abnormal_crypts_of0.65475972
96MP0006054_spinal_hemorrhage0.65108557
97MP0000703_abnormal_thymus_morphology0.63583938
98MP0003795_abnormal_bone_structure0.62827815
99MP0002136_abnormal_kidney_physiology0.62323672
100MP0003195_calcinosis0.62193619
101MP0002332_abnormal_exercise_endurance0.59156274
102MP0000767_abnormal_smooth_muscle0.54966930
103MP0005165_increased_susceptibility_to0.54155359
104MP0008873_increased_physiological_sensi0.53851955
105MP0003866_abnormal_defecation0.53754482
106MP0002019_abnormal_tumor_incidence0.53053435
107MP0000920_abnormal_myelination0.52216743
108MP0005535_abnormal_body_temperature0.52037848
109MP0005023_abnormal_wound_healing0.50977967
110MP0000609_abnormal_liver_physiology0.50490196
111MP0003045_fibrosis0.50294505
112MP0008004_abnormal_stomach_pH0.49852703
113MP0002877_abnormal_melanocyte_morpholog0.47672634
114MP0005319_abnormal_enzyme/_coenzyme0.45878108

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.72025893
2Recurrent bacterial skin infections (HP:0005406)7.08716252
3Eczematoid dermatitis (HP:0000976)6.83683437
4Recurrent gram-negative bacterial infections (HP:0005420)5.94806497
5Elevated erythrocyte sedimentation rate (HP:0003565)5.42367060
6Stomatitis (HP:0010280)5.27130478
7Abnormality of macrophages (HP:0004311)5.07746272
8Mediastinal lymphadenopathy (HP:0100721)5.05919548
9Optic neuritis (HP:0100653)4.62560473
10Retrobulbar optic neuritis (HP:0100654)4.62560473
11Myositis (HP:0100614)4.58407906
12Orchitis (HP:0100796)4.55068266
13Recurrent skin infections (HP:0001581)4.34690760
14Increased cerebral lipofuscin (HP:0011813)4.22730078
15Gingivitis (HP:0000230)4.18184788
16Systemic lupus erythematosus (HP:0002725)4.10548860
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.09595227
18Vacuolated lymphocytes (HP:0001922)4.02267924
19Autoimmune thrombocytopenia (HP:0001973)3.96130986
20Recurrent fungal infections (HP:0002841)3.94136954
21Obstructive lung disease (HP:0006536)3.73138429
22Chronic obstructive pulmonary disease (HP:0006510)3.73138429
23Vasculitis (HP:0002633)3.62094207
24Prostate neoplasm (HP:0100787)3.45419644
25Recurrent viral infections (HP:0004429)3.39136696
26Interstitial pulmonary disease (HP:0006530)3.27246770
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.26604458
28Periodontitis (HP:0000704)3.18800192
29Cellulitis (HP:0100658)3.15631881
30Pustule (HP:0200039)3.10133224
31Axonal loss (HP:0003447)3.09947385
32Pulmonary infiltrates (HP:0002113)3.09801712
33Thick nail (HP:0001805)3.07994799
34Recurrent cutaneous fungal infections (HP:0011370)3.02003576
35Chronic mucocutaneous candidiasis (HP:0002728)3.02003576
36Abnormality of glycolipid metabolism (HP:0010969)3.00908735
37Abnormality of liposaccharide metabolism (HP:0010968)3.00908735
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.00908735
39Disinhibition (HP:0000734)2.96974967
40Basal ganglia calcification (HP:0002135)2.91703277
41T lymphocytopenia (HP:0005403)2.90465035
42Leukocytosis (HP:0001974)2.88401829
43Chest pain (HP:0100749)2.87960757
44Urticaria (HP:0001025)2.87397433
45Meningitis (HP:0001287)2.83228388
46Dysostosis multiplex (HP:0000943)2.78460068
47Keratoconjunctivitis sicca (HP:0001097)2.77048667
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.76618409
49Increased IgE level (HP:0003212)2.74321361
50Arterial thrombosis (HP:0004420)2.68383962
51Agammaglobulinemia (HP:0004432)2.67812163
52Abnormal platelet volume (HP:0011876)2.67482935
53Osteomyelitis (HP:0002754)2.65414115
54Recurrent pneumonia (HP:0006532)2.65029131
55Increased IgM level (HP:0003496)2.63294926
56Autoimmune hemolytic anemia (HP:0001890)2.63142031
57Hematochezia (HP:0002573)2.61646593
58Glomerulonephritis (HP:0000099)2.60801127
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58046695
60Panhypogammaglobulinemia (HP:0003139)2.57116938
61Gangrene (HP:0100758)2.56736151
62Keratoconjunctivitis (HP:0001096)2.52081121
63Gingival bleeding (HP:0000225)2.50993132
64Myocardial infarction (HP:0001658)2.48095904
65Abnormality of T cells (HP:0002843)2.47432332
66Petechiae (HP:0000967)2.44032037
67Increased serum ferritin (HP:0003281)2.42539872
68Colitis (HP:0002583)2.40869000
69Pulmonary embolism (HP:0002204)2.40815148
70Amyloidosis (HP:0011034)2.40781542
71Amaurosis fugax (HP:0100576)2.38045227
72Hemoptysis (HP:0002105)2.37873946
73Agnosia (HP:0010524)2.37443277
74Tetraparesis (HP:0002273)2.35961740
75Episodic fever (HP:0001954)2.34777815
76Granulocytopenia (HP:0001913)2.31435462
77Increased mean platelet volume (HP:0011877)2.25923923
78Recurrent lower respiratory tract infections (HP:0002783)2.25227038
79Osteolytic defects of the hand bones (HP:0009699)2.24094107
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.24094107
81Abnormality of the prostate (HP:0008775)2.22273118
82Premature loss of primary teeth (HP:0006323)2.21876816
83Chronic otitis media (HP:0000389)2.21199290
84Gastrointestinal infarctions (HP:0005244)2.20955365
85Urinary glycosaminoglycan excretion (HP:0003541)2.19666585
86Mucopolysacchariduria (HP:0008155)2.19666585
87Abnormality of iron homeostasis (HP:0011031)2.18676430
88Impaired platelet aggregation (HP:0003540)2.18362517
89Abnormal platelet function (HP:0011869)2.18362517
90Abnormality of T cell physiology (HP:0011840)2.17874585
91Vertigo (HP:0002321)2.14579203
92Hypergammaglobulinemia (HP:0010702)2.14307215
93Inflammation of the large intestine (HP:0002037)2.13337519
94Hepatosplenomegaly (HP:0001433)2.12868113
95Abnormality of polysaccharide metabolism (HP:0011012)2.12830516
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12830516
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12830516
98Glomerulopathy (HP:0100820)2.12642820
99Eosinophilia (HP:0001880)2.12567774
100Lymphopenia (HP:0001888)2.12218193
101Sepsis (HP:0100806)2.09907048
102Bone pain (HP:0002653)2.09435893
103Thrombocytosis (HP:0001894)2.06973072
104Joint swelling (HP:0001386)2.06968844
105Recurrent bronchitis (HP:0002837)2.06783183
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.05934561
107Recurrent sinusitis (HP:0011108)2.03008223
108Purpura (HP:0000979)2.00862040
109Abnormality of the peritoneum (HP:0002585)1.99981848
110Menorrhagia (HP:0000132)1.99682095
111Arthralgia (HP:0002829)1.98020052
112Epistaxis (HP:0000421)1.96150389
113Gastrointestinal inflammation (HP:0004386)1.93602768
114Restrictive lung disease (HP:0002091)1.92324507
115Prolonged bleeding time (HP:0003010)1.92247727
116Abnormality of T cell number (HP:0011839)1.92212349
117Pathologic fracture (HP:0002756)1.92013543
118Anorexia (HP:0002039)1.91413968
119Encephalitis (HP:0002383)1.90839274
120Loss of speech (HP:0002371)1.90718754
121Gastrointestinal stroma tumor (HP:0100723)1.90269109
122Abnormality of the pleura (HP:0002103)1.89946792
123Nephritis (HP:0000123)1.89383629
124Spontaneous hematomas (HP:0007420)1.88998663
125Abnormality of the pericardium (HP:0001697)1.88773258
126Joint hemorrhage (HP:0005261)1.88319230
127IgM deficiency (HP:0002850)1.85413520
128Progressive visual loss (HP:0000529)1.82596813
129Upper motor neuron abnormality (HP:0002127)1.82169898
130Polyneuropathy (HP:0001271)1.81939230
131Skin ulcer (HP:0200042)1.81130952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.44902934
2RIPK44.41382890
3BLK3.98385810
4IRAK33.67558374
5TBK13.48314127
6MAP4K13.27056121
7IRAK43.25427909
8TXK2.88287153
9TYK22.84620673
10IKBKB2.54014266
11PRPF4B2.44990496
12IKBKE2.42200901
13JAK32.35868653
14KIT2.25711800
15PBK2.21197379
16JAK11.90275817
17MAP3K131.82384009
18ZAP701.73697229
19CSK1.69838715
20CSF1R1.67565446
21TAOK31.64666983
22TGFBR21.64628079
23CHUK1.61774752
24SYK1.58488266
25PIM21.56070468
26HCK1.47060883
27ERN11.46972186
28FGR1.37980365
29TNK21.33410410
30LYN1.32914555
31TESK21.32895207
32BTK1.30295053
33LCK1.23670085
34MATK1.21189610
35STK101.18448765
36TAOK11.17853800
37EPHB11.17352584
38RPS6KA41.13269043
39TEC1.13090095
40PIM11.12598036
41FES1.12531123
42NEK91.11771921
43BMPR21.09189967
44JAK21.07924917
45MARK31.02380930
46MST40.94972435
47GRK70.93979383
48ITK0.93291669
49CLK10.91212049
50EIF2AK20.86808072
51MAP2K30.86223327
52NME20.80475777
53MST1R0.80147718
54CDC42BPA0.77208379
55STK40.76110168
56BMX0.73512368
57PRKCD0.72839628
58SIK20.72336169
59CAMK1D0.71494543
60EGFR0.70004666
61SIK30.69791425
62YES10.69266718
63ABL20.67458417
64MAP3K100.66457484
65ABL10.65409051
66TRPM70.63393619
67RIPK10.60397870
68FGFR30.60234459
69MAPK120.59703312
70MAP3K50.58532434
71MAPK70.58135114
72IRAK10.57386870
73EPHA30.56770329
74MAP3K30.52467220
75TTN0.49849897
76KSR20.48979872
77DDR20.48095953
78MAPKAPK20.47854498
79CDK120.46419770
80LRRK20.45512589
81CAMKK20.44537786
82MAPK40.43817075
83HIPK20.42387961
84STK30.42225511
85CAMK1G0.41734320
86PRKCQ0.41116371
87IRAK20.40680536
88ADRBK20.39686050
89MAP2K60.39188107
90MOS0.38303900
91FYN0.37306384
92KDR0.36299492
93FGFR40.35882089
94STK240.35529459
95DAPK20.35367109
96RPS6KC10.35140392
97RPS6KL10.35140392
98MAP3K110.33947592
99PDK10.33853855
100CDK60.31829032
101PTK60.31542606
102RPS6KA60.30490690
103FLT30.30378653
104MARK20.29166770
105PDGFRB0.28582525
106MAP3K10.28531678
107MAPK110.28234932
108IGF1R0.28066882
109CDK40.27996639
110ACVR1B0.27745557
111GRK60.25768035
112MAP3K60.25254988
113ERBB30.24401619
114PDPK10.24073194
115INSR0.21777856
116MAPK30.21730570
117TAOK20.21160650
118PIK3CG0.20670167
119GSK3A0.19534865
120BMPR1B0.19489585
121DAPK30.19180500
122PLK20.18354904
123PTK2B0.18261027
124ALK0.17974405
125ERBB40.17746811
126PRKG20.17623940

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.54590336
2Leishmaniasis_Homo sapiens_hsa051403.41051038
3Staphylococcus aureus infection_Homo sapiens_hsa051503.12025742
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.86197111
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.75354823
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.66200081
7Legionellosis_Homo sapiens_hsa051342.60956991
8Osteoclast differentiation_Homo sapiens_hsa043802.54529533
9Allograft rejection_Homo sapiens_hsa053302.49807505
10Pertussis_Homo sapiens_hsa051332.42570077
11Malaria_Homo sapiens_hsa051442.34491267
12Tuberculosis_Homo sapiens_hsa051522.29562920
13Rheumatoid arthritis_Homo sapiens_hsa053232.27830027
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26994462
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21372744
16Type I diabetes mellitus_Homo sapiens_hsa049402.04487889
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.03284812
18Measles_Homo sapiens_hsa051622.02392279
19TNF signaling pathway_Homo sapiens_hsa046681.93792040
20Asthma_Homo sapiens_hsa053101.84336651
21B cell receptor signaling pathway_Homo sapiens_hsa046621.83026471
22Hematopoietic cell lineage_Homo sapiens_hsa046401.82470228
23Lysosome_Homo sapiens_hsa041421.77884244
24Influenza A_Homo sapiens_hsa051641.77219601
25Salmonella infection_Homo sapiens_hsa051321.72159616
26Phagosome_Homo sapiens_hsa041451.68278661
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.67378073
28African trypanosomiasis_Homo sapiens_hsa051431.65913619
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60696330
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58707819
31Toxoplasmosis_Homo sapiens_hsa051451.50654900
32Herpes simplex infection_Homo sapiens_hsa051681.44283922
33Other glycan degradation_Homo sapiens_hsa005111.37814488
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36670372
35Chemokine signaling pathway_Homo sapiens_hsa040621.36666831
36Apoptosis_Homo sapiens_hsa042101.36650306
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.36107426
38Antigen processing and presentation_Homo sapiens_hsa046121.34367167
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33918076
40Shigellosis_Homo sapiens_hsa051311.24095232
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.20744726
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13589204
43Hepatitis B_Homo sapiens_hsa051611.13114072
44Autoimmune thyroid disease_Homo sapiens_hsa053201.12917543
45Primary immunodeficiency_Homo sapiens_hsa053401.04560255
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02991086
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00103791
48T cell receptor signaling pathway_Homo sapiens_hsa046600.99488106
49Viral myocarditis_Homo sapiens_hsa054160.99030719
50Amoebiasis_Homo sapiens_hsa051460.95178783
51Hepatitis C_Homo sapiens_hsa051600.94631353
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.84446303
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80577453
54Acute myeloid leukemia_Homo sapiens_hsa052210.72735304
55Systemic lupus erythematosus_Homo sapiens_hsa053220.71896117
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71829224
57Complement and coagulation cascades_Homo sapiens_hsa046100.70970131
58Chronic myeloid leukemia_Homo sapiens_hsa052200.70118133
59Prion diseases_Homo sapiens_hsa050200.66987050
60Platelet activation_Homo sapiens_hsa046110.66703759
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.65051076
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63038380
63Epstein-Barr virus infection_Homo sapiens_hsa051690.62510131
64Pancreatic cancer_Homo sapiens_hsa052120.61725337
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61227379
66Collecting duct acid secretion_Homo sapiens_hsa049660.57194347
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56672773
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.54117996
69Type II diabetes mellitus_Homo sapiens_hsa049300.50359638
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.48303675
71Prolactin signaling pathway_Homo sapiens_hsa049170.48211539
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47853159
73Small cell lung cancer_Homo sapiens_hsa052220.43178821
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41386082
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40003916
76HIF-1 signaling pathway_Homo sapiens_hsa040660.38547362
77Viral carcinogenesis_Homo sapiens_hsa052030.38503701
78Caffeine metabolism_Homo sapiens_hsa002320.37845368
79Bladder cancer_Homo sapiens_hsa052190.37403023
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35786364
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32605309
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32571755
83VEGF signaling pathway_Homo sapiens_hsa043700.30977501
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30285407
85Sphingolipid metabolism_Homo sapiens_hsa006000.28660005
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.28381129
87Endocytosis_Homo sapiens_hsa041440.27786828
88Proteoglycans in cancer_Homo sapiens_hsa052050.26846401
89HTLV-I infection_Homo sapiens_hsa051660.26681502
90Dorso-ventral axis formation_Homo sapiens_hsa043200.25367035
91Insulin resistance_Homo sapiens_hsa049310.25170100
92GnRH signaling pathway_Homo sapiens_hsa049120.23578763
93Mineral absorption_Homo sapiens_hsa049780.23363719
94FoxO signaling pathway_Homo sapiens_hsa040680.23328202
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22651706
96MicroRNAs in cancer_Homo sapiens_hsa052060.22328056
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21262791
98MAPK signaling pathway_Homo sapiens_hsa040100.20664360
99Notch signaling pathway_Homo sapiens_hsa043300.19005047
100Renal cell carcinoma_Homo sapiens_hsa052110.16153580
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14678274
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14615880
103Renin-angiotensin system_Homo sapiens_hsa046140.13721609
104mTOR signaling pathway_Homo sapiens_hsa041500.10834274
105Choline metabolism in cancer_Homo sapiens_hsa052310.10596687
106Arachidonic acid metabolism_Homo sapiens_hsa005900.09958249
107Non-small cell lung cancer_Homo sapiens_hsa052230.09014200
108p53 signaling pathway_Homo sapiens_hsa041150.08991508
109Inositol phosphate metabolism_Homo sapiens_hsa005620.08780719

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